Amalia Lafuente

Summary

Affiliation: Universitat de Barcelona
Country: Spain

Publications

  1. doi request reprint Polymorphism of dopamine D2 receptor (TaqIA, TaqIB, and-141C Ins/Del) and dopamine degradation enzyme (COMT G158A, A-278G) genes and extrapyramidal symptoms in patients with schizophrenia and bipolar disorders
    Amalia Lafuente
    Department of Pharmacology, University of Barcelona, IDIBAPS, Casanova 143, E 08036 Barcelona, Spain
    Psychiatry Res 161:131-41. 2008
  2. doi request reprint -141C Ins/Del polymorphism of the dopamine D2 receptor gene is associated with schizophrenia in a Spanish population
    Amalia Lafuente
    Pharmacology Department, School of Medicine, IDIBAPS, University of Barcelona, Casanova 143, Barcelona, Spain
    Psychiatr Genet 18:122-7. 2008
  3. ncbi request reprint Dopamine transporter (DAT) genotype (VNTR) and phenotype in extrapyramidal symptoms induced by antipsychotics
    Amalia Lafuente
    Dep Farmacología y Química Terapéutica, Universidad de Barcelona, IDIBAPS, Casanova 143, E 08036 Barcelona, Spain
    Schizophr Res 90:115-22. 2007
  4. pmc A functional variant provided further evidence for the association of ARVCF with schizophrenia
    Sergi Mas
    Department Anatomic Pathology, University of Barcelona, Barcelona, Spain
    Am J Med Genet B Neuropsychiatr Genet 153:1052-9. 2010
  5. doi request reprint Lack of association between antipsychotic-induced extrapyramidal symptoms and polymorphisms in dopamine metabolism and transport genes
    Patricia Gasso
    Dept Anatomic Pathology, Pharmacology and Microbiology, University of Barcelona, Barcelona, Spain
    Psychiatry Res 175:173-5. 2010
  6. doi request reprint Lack of association between schizophrenia and polymorphisms in dopamine metabolism and transport genes
    Santi Alvarez
    Department of Anatomic Pathology, Pharmacology and Microbiology, University of Barcelona, Casanova 143, E 08036 Barcelona, Spain
    Fundam Clin Pharmacol 24:741-7. 2010
  7. doi request reprint Effect of CYP2D6 on risperidone pharmacokinetics and extrapyramidal symptoms in healthy volunteers: results from a pharmacogenetic clinical trial
    Patricia Gasso
    Department of Anatomic Pathology, Pharmacology and Microbiology, School of Medicine, University of Barcelona, IDIBAPS, Casanova 143, E 08036 Barcelona, Spain
    Pharmacogenomics 15:17-28. 2014
  8. ncbi request reprint Lower specific micronutrient intake in colorectal cancer patients with tumors presenting promoter hypermethylation in p16(INK4a), p4(ARF) and hMLH1
    Sergi Mas
    Department of Pharmacology, School of Medicine, IDIBAPS, University of Barcelona, Casanova 143, 08036 Barcelona, Spain
    Anticancer Res 27:1151-6. 2007
  9. doi request reprint Insertion/deletion polymorphism of the angiotensin-converting enzyme gene is associated with schizophrenia in a Spanish population
    Anna Crescenti
    Anatomia Patologica, Farmacología y Microbiología, Universidad de Barcelona IDIBAPS Casanova 143, E 08036 Barcelona, Spain
    Psychiatry Res 165:175-80. 2009
  10. doi request reprint A common variant of the ABO gene protects against hypertension in a Spanish population
    Patricia Gasso
    Department of Pathological Anatomy, University of Barcelona, Barcelona, Spain
    Hypertens Res 35:592-6. 2012

Collaborators

Detail Information

Publications43

  1. doi request reprint Polymorphism of dopamine D2 receptor (TaqIA, TaqIB, and-141C Ins/Del) and dopamine degradation enzyme (COMT G158A, A-278G) genes and extrapyramidal symptoms in patients with schizophrenia and bipolar disorders
    Amalia Lafuente
    Department of Pharmacology, University of Barcelona, IDIBAPS, Casanova 143, E 08036 Barcelona, Spain
    Psychiatry Res 161:131-41. 2008
    ..These results are of interest in view of the increased use of antipsychotic drugs in bipolar patients in both the acute manic and the depressive phase...
  2. doi request reprint -141C Ins/Del polymorphism of the dopamine D2 receptor gene is associated with schizophrenia in a Spanish population
    Amalia Lafuente
    Pharmacology Department, School of Medicine, IDIBAPS, University of Barcelona, Casanova 143, Barcelona, Spain
    Psychiatr Genet 18:122-7. 2008
    ..In this study we examined the relationship between dopamine D2 receptor (DRD2) polymorphisms (TaqIA, TaqIB, -141C Ins/Del) and dopamine D3 receptor (DRD3) Ser9Gly polymorphism and the risk of schizophrenia in a Spanish population...
  3. ncbi request reprint Dopamine transporter (DAT) genotype (VNTR) and phenotype in extrapyramidal symptoms induced by antipsychotics
    Amalia Lafuente
    Dep Farmacología y Química Terapéutica, Universidad de Barcelona, IDIBAPS, Casanova 143, E 08036 Barcelona, Spain
    Schizophr Res 90:115-22. 2007
    ..Impaired dopamine transporter (DAT) function may be involved in antipsychotic (AP)-induced extrapyramidal symptoms (EPS). A polymorphism involving a variable number of tandem repeats (VNTR) has been described in the DAT gene (SLC6A3)...
  4. pmc A functional variant provided further evidence for the association of ARVCF with schizophrenia
    Sergi Mas
    Department Anatomic Pathology, University of Barcelona, Barcelona, Spain
    Am J Med Genet B Neuropsychiatr Genet 153:1052-9. 2010
    ..The functional variant rs165815, which affects a critical region of ARVCF, is a considerable source of the genetic variability associated with the risk of developing schizophrenia...
  5. doi request reprint Lack of association between antipsychotic-induced extrapyramidal symptoms and polymorphisms in dopamine metabolism and transport genes
    Patricia Gasso
    Dept Anatomic Pathology, Pharmacology and Microbiology, University of Barcelona, Barcelona, Spain
    Psychiatry Res 175:173-5. 2010
    ..We did not find evidence of the involvement of these polymorphisms in the predisposition towards or protection from EPS...
  6. doi request reprint Lack of association between schizophrenia and polymorphisms in dopamine metabolism and transport genes
    Santi Alvarez
    Department of Anatomic Pathology, Pharmacology and Microbiology, University of Barcelona, Casanova 143, E 08036 Barcelona, Spain
    Fundam Clin Pharmacol 24:741-7. 2010
    ..Polymorphisms in genes coding for dopamine metabolism and transport enzymes did not predispose to or protect from schizophrenia and related disorders...
  7. doi request reprint Effect of CYP2D6 on risperidone pharmacokinetics and extrapyramidal symptoms in healthy volunteers: results from a pharmacogenetic clinical trial
    Patricia Gasso
    Department of Anatomic Pathology, Pharmacology and Microbiology, School of Medicine, University of Barcelona, IDIBAPS, Casanova 143, E 08036 Barcelona, Spain
    Pharmacogenomics 15:17-28. 2014
    ..To elucidate the relationship between CYP2D6 genotype and risperidone pharmacokinetics and extrapyramidal symptoms we propose the APSEP pharmacogenetic clinical trial...
  8. ncbi request reprint Lower specific micronutrient intake in colorectal cancer patients with tumors presenting promoter hypermethylation in p16(INK4a), p4(ARF) and hMLH1
    Sergi Mas
    Department of Pharmacology, School of Medicine, IDIBAPS, University of Barcelona, Casanova 143, 08036 Barcelona, Spain
    Anticancer Res 27:1151-6. 2007
    ....
  9. doi request reprint Insertion/deletion polymorphism of the angiotensin-converting enzyme gene is associated with schizophrenia in a Spanish population
    Anna Crescenti
    Anatomia Patologica, Farmacología y Microbiología, Universidad de Barcelona IDIBAPS Casanova 143, E 08036 Barcelona, Spain
    Psychiatry Res 165:175-80. 2009
    ..This protection is explained by the additive genotype risk model, in which the protection increases with the number of D alleles. Our results indicate that the ACE D allele is involved in the development of schizophrenia...
  10. doi request reprint A common variant of the ABO gene protects against hypertension in a Spanish population
    Patricia Gasso
    Department of Pathological Anatomy, University of Barcelona, Barcelona, Spain
    Hypertens Res 35:592-6. 2012
    ..Further studies are required to confirm this association...
  11. doi request reprint Association of A/G polymorphism in intron 13 of the monoamine oxidase B gene with schizophrenia in a Spanish population
    Patricia Gasso
    Department of Anatomic Pathology, Pharmacology and Microbiology, University of Barcelona, IDIBAPS, Barcelona, Spain
    Neuropsychobiology 58:65-70. 2008
    ..Monoamine oxidase B (MAO-B) enzyme is involved in the oxidative metabolism of dopamine. We studied whether the A644G polymorphism in intron 13 of the MAO-B gene is a risk factor for schizophrenia...
  12. doi request reprint Cyp2d6*3, *4, *5 and *6 polymorphisms and antipsychotic-induced extrapyramidal side-effects in patients receiving antipsychotic therapy
    Anna Crescenti
    Department of Pharmacology, School of Medicine, IDIBAPS, University of Barcelona, Barcelona, Spain
    Clin Exp Pharmacol Physiol 35:807-11. 2008
    ..4, 95% CI 1.13-18, permutated P value 0.003) and the risk of suffering EPS. 3. These results suggest that the CYP2D6 genotype may be a contributory factor in the development of EPS in patients undergoing AP therapy...
  13. doi request reprint Searching for functional SNPs or rare variants in exonic regions of DRD3 in risperidone-treated patients
    Patricia Gasso
    Dept of Anatomic Pathology, Pharmacology and Microbiology, University of Barcelona, Casanova 143, E 08036 Barcelona, Spain
    Eur Neuropsychopharmacol 21:294-9. 2011
    ..Our results suggest that, rather than exonic regions, regulatory regions and introns could be related to the associations reported for DRD3 and the incidence of locomotor side-effects...
  14. doi request reprint Sulforaphane protects SK-N-SH cells against antipsychotic-induced oxidative stress
    Sergi Mas
    Department of Anatomic Pathology, Pharmacology and Microbiology, University of Barcelona, Casanova 143, E 08036 Barcelona, Spain
    Fundam Clin Pharmacol 26:712-21. 2012
    ..Furthermore, SF could provide protective effects against AP-induced toxicity in dopaminergic cells...
  15. doi request reprint ARVCF single marker and haplotypic association with schizophrenia
    Sergi Mas
    Department of Anatomic Pathology, Pharmacology and Microbiology, University of Barcelona, Casanova 143, E 08036 Barcelona, Spain
    Prog Neuropsychopharmacol Biol Psychiatry 33:1064-9. 2009
    ..Our results will assist in the interpretation of the controversy generated by genetic associations of COMT and schizophrenia, which could be the result of different LD patterns between COMT markers and the 3' region of the ARVCF gene...
  16. doi request reprint Relationship between CYP2D6 genotype and haloperidol pharmacokinetics and extrapyramidal symptoms in healthy volunteers
    Patricia Gasso
    Department of Anatomic Pathology, Pharmacology and Microbiology, School of Medicine, University of Barcelona, IDIBAPS, Casanova 143, E 08036 Barcelona, Spain
    Pharmacogenomics 14:1551-63. 2013
    ..This study aimed to elucidate the relationship between CYP2D6 genotype and haloperidol pharmacokinetics and induced extrapyramidal symptoms (EPSs)...
  17. ncbi request reprint Simultaneous genotyping of CYP2C9*2, *3, and 5' flanking region (C-1189T) polymorphisms in a Spanish population through a new minisequencing multiplex single-base extension analysis
    Sergi Mas
    Departamento Farmacologia y Química Terapeutica, Facultad de Medicina, IDIBAPS, Universidad de Barcelona, Casanova 143, 08036 Barcelona, Spain
    Eur J Clin Pharmacol 61:635-41. 2005
    ....
  18. ncbi request reprint Induction of apoptosis in HT-29 cells by extracts from isothiocyanates-rich varieties of Brassica oleracea
    Sergi Mas
    Departamento de Farmacologia y Quimica Terapeutica, IDIBAPS, Facultad de Medicina, Universidad de Barcelona, Casanova 143, 08036 Barcelona, Spain
    Nutr Cancer 58:107-14. 2007
    ..54 to 7.08 mug/mL, which are achievable in vivo. Our results showed that ITC concentration and the chemopreventive responses of plant extracts vary among the varieties of Brassica Oleracea studied and among their cultivars...
  19. doi request reprint Epigenetic and genetic variants in the HTR1B gene and clinical improvement in children and adolescents treated with fluoxetine
    Patricia Gasso
    Department of Pathological Anatomy, Pharmacology and Microbiology, University of Barcelona, Spain Institut D investigacions Biomèdiques August Pi i Sunyer IDIBAPS, Barcelona, Spain
    Prog Neuropsychopharmacol Biol Psychiatry . 2016
    ..These results give new evidence for the role of epigenetic and genetic factors which could modulate HTR1B expression in the pharmacological response to antidepressants...
  20. doi request reprint Increased susceptibility to apoptosis in cultured fibroblasts from antipsychotic-naïve first-episode schizophrenia patients
    Patricia Gasso
    Dept Pathological Anatomy, Pharmacology and Microbiology, University of Barcelona, Spain Institut D investigacions Biomèdiques August Pi i Sunyer IDIBAPS, Barcelona, Spain Electronic address
    J Psychiatr Res 48:94-101. 2014
    ..These results strongly support the hypothesis that first-episode schizophrenia patients may have increased susceptibility to apoptosis, which may be involved in the onset and progression of the disease...
  21. doi request reprint Common genetic background in anorexia nervosa and obsessive compulsive disorder: preliminary results from an association study
    Sergi Mas
    Department of Anatomic Pathology, Pharmacology and Microbiology, University of Barcelona, Spain
    J Psychiatr Res 47:747-54. 2013
    ..However, the results must be replicated in studies with larger cohorts in order to confirm these associations...
  22. ncbi request reprint DNA cards: determinants of DNA yield and quality in collecting genetic samples for pharmacogenetic studies
    Sergi Mas
    Department of Pharmacology and Therapeutic Chemistry, Faculty of Medicine, University of Barcelona, Barcelona, Spain
    Basic Clin Pharmacol Toxicol 101:132-7. 2007
    ..In conclusion, our study shows that both DNA cards, IsoCode Cards and FTA Classic Cards, facilitate genetic and pharmacogenetic testing for routine clinical practice...
  23. pmc Integrating Genetic, Neuropsychological and Neuroimaging Data to Model Early-Onset Obsessive Compulsive Disorder Severity
    Sergi Mas
    Dept Anatomic Pathology, Pharmacology and Microbiology, University of Barcelona, Barcelona, Spain
    PLoS ONE 11:e0153846. 2016
    ..70 in the validation sample. Above its clinical applicability, the combination of particular neuropsychological, neuroimaging, and genetic characteristics could enhance our understanding of the neurobiological basis of the disorder. ..
  24. doi request reprint Plasma fluoxetine concentrations and clinical improvement in an adolescent sample diagnosed with major depressive disorder, obsessive-compulsive disorder, or generalized anxiety disorder
    Ana Blázquez
    From the Department of Child and Adolescent Psychiatry and Psychology, Institute of Neurosciences, Hospital Clinic de Barcelona Department of Anatomic Pathology, Pharmacology and Microbiology, University of Barcelona Institut d Investigacions Biomèdiques August Pi i Sunyer IDIBAPS Centro de Investigación Biomédica en Red de Salud Mental CIBERSAM Pharmacology and Toxicology Department, CDB, Hospital Clínic de Barcelona Clinical Pharmacology Department, Hospital Clínic de Barcelona and Department of Psychiatry and Clinical Psychobiology, University of Barcelona, Barcelona, Spain
    J Clin Psychopharmacol 34:318-26. 2014
    ..Fluoxetine (FLX) has been one of the most widely studied selective serotonin reuptake inhibitors in adolescents. Despite its efficacy, however, 30% to 40% of patients do not respond to treatment...
  25. doi request reprint Neurotoxic/neuroprotective activity of haloperidol, risperidone and paliperidone in neuroblastoma cells
    Patricia Gasso
    Department Pathological Anatomy, Pharmacology and Microbiology, University of Barcelona, Spain
    Prog Neuropsychopharmacol Biol Psychiatry 36:71-7. 2012
    ..Of the APs tested, paliperidone always showed the strongest neuroprotective effect. The different antipsychotic effects on survival and cell death might be related to differences in their capacity to induce EPS...
  26. doi request reprint Xenobiotic metabolizing and transporter genes: gene-gene interactions in schizophrenia and related disorders
    Patricia Gasso
    Department of Anatomic Pathology, University of Barcelona, Casanova 143, E 08036, Barcelona, Spain
    Pharmacogenomics 11:1725-31. 2010
    ..In this study we explored possible epistasis between CYP2D6 (*3, *4, *5, *6 and *1xN), CYP3A5 (*3), CYP1A2 (*1C and *1F) and ABCB1 (G2677T) in schizophrenia and related disorders...
  27. doi request reprint Association between genetic variants of serotonergic and glutamatergic pathways and the concentration of neurometabolites of the anterior cingulate cortex in paediatric patients with obsessive-compulsive disorder
    Ana E Ortiz
    a Department of Child and Adolescent Psychiatry and Psychology, Institute of Neurosciences, Hospital Clinic, Barcelona, Spain
    World J Biol Psychiatry 17:394-404. 2016
    ....
  28. doi request reprint Functional analysis of gene expression in risperidone treated cells provide new insights in molecular mechanism and new candidate genes for pharmacogenetic studies
    Sergi Mas
    Department of Anatomic Pathology, Pharmacology and Microbiology, University of Barcelona, Casanova 143, E 08036 Barcelona, Spain
    Eur Neuropsychopharmacol 23:329-37. 2013
    ....
  29. doi request reprint Strengths and weaknesses of pharmacogenetic studies of antipsychotic drugs: the potential value of the PEPs study
    Sergi Mas
    Department of Anatomic Pathology, Pharmacology and Microbiology, University of Barcelona, IDIBAPS, Casanova 143, E 08036 Barcelona, Spain
    Pharmacogenomics 13:1773-82. 2012
    ..Application of a predictive model in first psychotic episodes' (known as the PEPs study, from the Spanish abbreviation) in pharmacogenetic studies...
  30. ncbi request reprint Induction of NAD(P)H quinone oxidoreductase by vegetables widely consumed in Catalonia, Spain
    Nuria Laso
    Departamento de Farmacologia y Quimica Terapeutica, IDIBAPS, Facultad de Medicina, Universidad de Barcelona, Spain
    Nutr Cancer 52:49-58. 2005
    ..These results are very similar to those described for vegetables consumed in the United States, with the exception of calcot, which is common in Catalonia but is not grown or consumed widely in the United States...
  31. doi request reprint Secondary nonmotor negative symptoms in healthy volunteers after single doses of haloperidol and risperidone: a double-blind, crossover, placebo-controlled trial
    Sergi Mas
    Department of Pathological Anatomy, Pharmacology and Microbiology, School of Medicine, University of Barcelona, Barcelona, Spain Institut D investigacions Biomèdiques August Pi i Sunyer IDIBAPS, Barcelona, Spain Centro de Investigación Biomédica en Red de Salud Mental CIBERSAM, Madrid, Spain
    Hum Psychopharmacol 28:586-93. 2013
    ..The effect of antipsychotics (APs) on negative symptoms is controversial. The present study assessed negative symptoms in healthy volunteers without any source of primary negative symptoms after single doses of haloperidol and risperidone...
  32. ncbi request reprint Effects of milk supplementation with conjugated linoleic acid (isomers cis-9, trans-11 and trans-10, cis-12) on body composition and metabolic syndrome components
    Nuria Laso
    Dep Farmacología y Química Terapéutica, Universidad de Barcelona, IDIBAPS, Casanova 143, E 08036 Barcelona, Spain
    Br J Nutr 98:860-7. 2007
    ..The supplementation of milk with 3 g CLA over 12 weeks results in a significant reduction of fat mass in overweight but not in obese subjects. CLA supplementation was not associated with any adverse effects or biological changes...
  33. doi request reprint Association of CACNA1C and SYNE1 in offspring of patients with psychiatric disorders
    Patricia Gasso
    Department of Pathological Anatomy, Pharmacology and Microbiology, University of Barcelona, Spain Institut D investigacions Biomèdiques August Pi i Sunyer IDIBAPS, Barcelona, Spain Electronic address
    Psychiatry Res 245:427-435. 2016
    ..This could help identify subjects with a very high genetic risk, in whom early detection and early intervention could lead to better prognosis...
  34. doi request reprint Association between genetic variants related to glutamatergic, dopaminergic and neurodevelopment pathways and white matter microstructure in child and adolescent patients with obsessive-compulsive disorder
    Patricia Gasso
    Department Anatomic Pathology, Pharmacology and Microbiology, University of Barcelona, Spain Institut D investigacions Biomèdiques August Pi i Sunyer IDIBAPS, Barcelona, Spain Electronic address
    J Affect Disord 186:284-92. 2015
    ..The objective of the present study was to explore the association between variability in genes related to the pathophysiology of OCD and altered WM microstructure previously identified in child and adolescent patients with the disease...
  35. doi request reprint The effect of age on DNA concentration from whole saliva: implications for the standard isolation method
    Patricia Gasso
    Department of Pathological Anatomy, Pharmacology, and Microbiology, University of Barcelona, Barcelona, 08036, Spain Institut D investigacions Biomèdiques August Pi i Sunyer IDIBAPS, Barcelona, 08036, Spain
    Am J Hum Biol 26:859-62. 2014
    ....
  36. doi request reprint Influence of ABO genotype and phenotype on angiotensin-converting enzyme plasma activity
    Patricia Gasso
    Department of Pathological Anatomy, Pharmacology and Microbiology, University of Barcelona, Spain Institut D investigacions Biomèdiques August Pi i Sunyer IDIBAPS, Spain
    J Renin Angiotensin Aldosterone Syst 15:580-4. 2014
    ..To study whether ABO rs495828 is associated with ACE activity. The association between ABO genotype and phenotype, and differences in ACE activity between the ABO phenotype groups were also studied...
  37. doi request reprint Fluoxetine pharmacogenetics in child and adult populations
    Ana Blázquez
    Department of Child and Adolescent Psychiatry and Psychology, Institute of Neurosciences, Hospital Clinic Universitari, Barcelona, Spain
    Eur Child Adolesc Psychiatry 21:599-610. 2012
    ..Comparison of different studies reveals that the results are not always consistent, probably due to methodological differences. Other factors such as gender or ethnicity may also influence treatment response...
  38. doi request reprint Pharmacogenetic predictors of angiotensin-converting enzyme inhibitor-induced cough: the role of ACE, ABO, and BDKRB2 genes
    Sergi Mas
    Department of Anatomic Pathology, University of Barcelona, Spain
    Pharmacogenet Genomics 21:531-8. 2011
    ..We included two polymorphisms in the ABO (related to ACE levels); two polymorphisms in the AGTR1, and one polymorphism in the BKRB1 (related to ACEi response)...
  39. pmc Evidence of activation of the Toll-like receptor-4 proinflammatory pathway in patients with schizophrenia
    Borja García-Bueno
    From the CIBERSAM ISCIII, Spain García Bueno, MacDowell, Callado, MAS, Bernardo, Lafuente, Meana, Leza the Department of Pharmacology, School of Medicine, Complutense University and Instituto de Investigación Hospital 12 de Octobre Imas12 Madrid García Bueno, MacDowell, Leza the Department of Anatomic Pathology, Pharmacology and Microbiology School of Medicine, University of Barcelona, Barcelona Gassó, MAS, Lafuente the Department of Pharmacology, University of Basque Country UPV EHU and BioCruces Institute, Bizkaia Callado, Meana the IDIBAPS Institut d Investigacions Biomèdiques August Pi i Sunyer, Barcelona Gassó, MAS, Bernardo, Lafuente and the Barcelona Clinic Schizophrenia Unit, Neuroscience Institute, Hospital Clinic of Barcelona Department of Psychiatry and Clinical Psychobiology, University of Barcelona Bernardo
    J Psychiatry Neurosci 41:E46-55. 2016
    ..The main agents of innate immunity are the Toll-like receptors (TLRs), which detect molecular patterns associated with damage and pathogens. The TLR first reported was TLR4, and it is still the most studied one...
  40. pmc Satisfaction survey with DNA cards method to collect genetic samples for pharmacogenetics studies
    Jose M Vidal-Taboada
    Pharmacogenomic Unit, RDES SL, Barcelona, Spain
    BMC Med Genet 7:45. 2006
    ....
  41. ncbi request reprint Decrease in specific micronutrient intake in colorectal cancer patients with tumors presenting Ki-ras mutation
    Nuria Laso
    Department of Pharmacologys, School of Medicine, IDIBAPS, University of Barcelona, Casanova 143, 08036 Barcelona, Spain
    Anticancer Res 24:2011-20. 2004
    ....
  42. pmc A Pharmacovigilance Study in First Episode of Psychosis: Psychopharmacological Interventions and Safety Profiles in the PEPs Project
    Miquel Bioque
    Barcelona Clínic Schizophrenia Unit, Hospital Clinic de Barcelona, CIBERSAM, Barcelona, Spain Drs Bioque, Cabrera, Mezquida, and Bernardo CICAB CAIBER Centro de Investigación Clínica, Hospital Universitario, Servicio Extremeño de Salud SES, Facultad de Medicina Universidad de Extremadura, CIBERSAM, Badajoz, Spain Dr Llerena Instituto de Investigación Sanitaria Aragón IIS Aragón, University of Zaragoza, Zaragoza, Spain Dr Lobo Department of Psychiatry, Hospital Universitario de Álava, CIBERSAM, University of the Basque Country, Vitoria, Spain Dr González Pinto Child and Adolescent Psychiatry Department, Hospital General Universitario Gregorio Maranon, IISGM, CIBERSAM, School of Medicine, Universidad Complutense, Madrid, Spain Drs Díaz Caneja and Parellada Department of Psychiatry, Hospital de Sant Pau, CIBERSAM, Barcelona, Spain Dr Corripio Clinic Hospital Valencia, INCLIVA, CIBERSAM, Valencia University, Valencia, Kresge Hearing Research Laboratory of the South
    Int J Neuropsychopharmacol 19:. 2016
    ..Realistic, naturalistic studies are necessary to represent the entire population of first episode of psychosis attended in daily practice...
  43. pmc Hnf1alpha (MODY3) controls tissue-specific transcriptional programs and exerts opposed effects on cell growth in pancreatic islets and liver
    Joan Marc Servitja
    Genomic Programming of Beta Cells Laboratory, Institut d Investigacions Biomediques August Pi i Sunyer IDIBAPS, Barcelona, Spain
    Mol Cell Biol 29:2945-59. 2009
    ..Collectively, these findings show that Hnf1alpha governs broad, highly tissue-specific genetic programs in pancreatic islets and liver and reveal key consequences of Hnf1a deficiency relevant to the pathophysiology of monogenic diabetes...