Adonina Tardon

Summary

Affiliation: Universidad de Oviedo
Country: Spain

Publications

  1. pmc Prenatal exposure to cooking gas and respiratory health in infants is modified by tobacco smoke exposure and diet in the INMA birth cohort study
    Ana Esplugues
    CIBER Epidemiologia y Salud Pública CIBERESP, Melchor Fernandez Almagro, 3 5, 28029, Madrid, Spain
    Environ Health 12:100. 2013
  2. pmc Relationship between area-level socioeconomic characteristics and outdoor NO2 concentrations in rural and urban areas of northern Spain
    Ana Fernandez-Somoano
    Spanish Consortium for Research on Epidemiology and Public Health CIBERESP, Instituto de Salud Carlos III, C Melchor Fernández Almagro, 3 5, Pabellón 6, Planta Baja, 28029, Madrid, Spain
    BMC Public Health 13:71. 2013
  3. pmc Genetic polymorphisms in CYP1A1, GSTM1, GSTP1 and GSTT1 metabolic genes and risk of lung cancer in Asturias
    M Felicitas López-Cima
    Molecular Epidemiology of Cancer Unit, University Institute of Oncology, University of Oviedo, C Fernando Bongera, S N, Oviedo, 33006, Spain
    BMC Cancer 12:433. 2012
  4. pmc Genetic polymorphisms in MMP 2, 9 and 3 genes modify lung cancer risk and survival
    Patricia González-Arriaga
    Departamento de Medicina, Unidad de Epidemiología Molecular del Cáncer del Instituto Universitario de Oncología del Principado de Asturias, Universidad de Oviedo, Spain
    BMC Cancer 12:121. 2012
  5. pmc Lung cancer risk and pollution in an industrial region of Northern Spain: a hospital-based case-control study
    María Felicitas López-Cima
    Cancer and Environmental Epidemiology Unit, National Center for Epidemiology, Carlos III Institute of Health, Avda, Monforte de Lemos, 5, 28029 Madrid, Spain
    Int J Health Geogr 10:10. 2011
  6. pmc Socioeconomic status and exposure to disinfection by-products in drinking water in Spain
    Gemma Castano-Vinyals
    Centre for Research in Environmental Epidemiology CREAL, Barcelona, Spain
    Environ Health 10:18. 2011
  7. pmc Leisure-time physical activity and lung cancer: a meta-analysis
    Adonina Tardon
    Division of Cancer Epidemiology and Genetics, National Cancer Institute, Bethesda, MD 20892, USA
    Cancer Causes Control 16:389-97. 2005
  8. pmc Genome-wide association study identifies multiple loci associated with bladder cancer risk
    Jonine D Figueroa
    Division of Cancer Epidemiology and Genetics, National Cancer Institute, Bethesda, MD, USA
    Hum Mol Genet 23:1387-98. 2014
  9. ncbi Evidence for an intensity-dependent interaction of NAT2 acetylation genotype and cigarette smoking in the Spanish Bladder Cancer Study
    Jay H Lubin
    Biostatistics Branch, Division of Cancer Epidemiology and Genetics, National Cancer Institute, 6120 Executive Blvd, Rockville, MD 20852, USA
    Int J Epidemiol 36:236-41. 2007
  10. pmc Polymorphisms in XPC, XPD, XRCC1, and XRCC3 DNA repair genes and lung cancer risk in a population of northern Spain
    M Felicitas López-Cima
    Departamento de Medicina, Facultad de Medicina, Unidad de Epidemiología Molecular del Instituto Universitario de Oncología, Universidad de Oviedo, 33006 Oviedo, Spain
    BMC Cancer 7:162. 2007

Detail Information

Publications43

  1. pmc Prenatal exposure to cooking gas and respiratory health in infants is modified by tobacco smoke exposure and diet in the INMA birth cohort study
    Ana Esplugues
    CIBER Epidemiologia y Salud Pública CIBERESP, Melchor Fernandez Almagro, 3 5, 28029, Madrid, Spain
    Environ Health 12:100. 2013
    ..The aim of this study is to analyze the association between the use of gas cooking at home during pregnancy and respiratory problems in children during their first year of life...
  2. pmc Relationship between area-level socioeconomic characteristics and outdoor NO2 concentrations in rural and urban areas of northern Spain
    Ana Fernandez-Somoano
    Spanish Consortium for Research on Epidemiology and Public Health CIBERESP, Instituto de Salud Carlos III, C Melchor Fernández Almagro, 3 5, Pabellón 6, Planta Baja, 28029, Madrid, Spain
    BMC Public Health 13:71. 2013
    ....
  3. pmc Genetic polymorphisms in CYP1A1, GSTM1, GSTP1 and GSTT1 metabolic genes and risk of lung cancer in Asturias
    M Felicitas López-Cima
    Molecular Epidemiology of Cancer Unit, University Institute of Oncology, University of Oviedo, C Fernando Bongera, S N, Oviedo, 33006, Spain
    BMC Cancer 12:433. 2012
    ....
  4. pmc Genetic polymorphisms in MMP 2, 9 and 3 genes modify lung cancer risk and survival
    Patricia González-Arriaga
    Departamento de Medicina, Unidad de Epidemiología Molecular del Cáncer del Instituto Universitario de Oncología del Principado de Asturias, Universidad de Oviedo, Spain
    BMC Cancer 12:121. 2012
    ..We have investigated the association between the -735 C/T, the -1171 5A/6A, and the -1562 C/T polymorphisms in the MMP2, MMP3 and MMP9 genes, respectively, and the risk and survival of lung cancer...
  5. pmc Lung cancer risk and pollution in an industrial region of Northern Spain: a hospital-based case-control study
    María Felicitas López-Cima
    Cancer and Environmental Epidemiology Unit, National Center for Epidemiology, Carlos III Institute of Health, Avda, Monforte de Lemos, 5, 28029 Madrid, Spain
    Int J Health Geogr 10:10. 2011
    ..The objective was to ascertain the possible effect of air pollution, both urban and industrial, on lung cancer risk in Asturias...
  6. pmc Socioeconomic status and exposure to disinfection by-products in drinking water in Spain
    Gemma Castano-Vinyals
    Centre for Research in Environmental Epidemiology CREAL, Barcelona, Spain
    Environ Health 10:18. 2011
    ..Disinfection by-products in drinking water are chemical contaminants that have been associated with cancer and other adverse effects. Exposure occurs from consumption of tap water, inhalation and dermal absorption...
  7. pmc Leisure-time physical activity and lung cancer: a meta-analysis
    Adonina Tardon
    Division of Cancer Epidemiology and Genetics, National Cancer Institute, Bethesda, MD 20892, USA
    Cancer Causes Control 16:389-97. 2005
    ..Several studies have evaluated the relationship between physical activity and lung cancer. To summarize and review these studies, we conducted a meta-analysis of all relevant reports published from 1966 through October 2003...
  8. pmc Genome-wide association study identifies multiple loci associated with bladder cancer risk
    Jonine D Figueroa
    Division of Cancer Epidemiology and Genetics, National Cancer Institute, Bethesda, MD, USA
    Hum Mol Genet 23:1387-98. 2014
    ....
  9. ncbi Evidence for an intensity-dependent interaction of NAT2 acetylation genotype and cigarette smoking in the Spanish Bladder Cancer Study
    Jay H Lubin
    Biostatistics Branch, Division of Cancer Epidemiology and Genetics, National Cancer Institute, 6120 Executive Blvd, Rockville, MD 20852, USA
    Int J Epidemiol 36:236-41. 2007
    ..9 in never-smokers and 1.6 in ever-smokers, a 1.8-fold enhancement in smokers. Evidence indicates that acetylation is an exposure-dependent process, and thus the magnitude of the interaction may also depend on exposure level...
  10. pmc Polymorphisms in XPC, XPD, XRCC1, and XRCC3 DNA repair genes and lung cancer risk in a population of northern Spain
    M Felicitas López-Cima
    Departamento de Medicina, Facultad de Medicina, Unidad de Epidemiología Molecular del Instituto Universitario de Oncología, Universidad de Oviedo, 33006 Oviedo, Spain
    BMC Cancer 7:162. 2007
    ....
  11. pmc A multi-stage genome-wide association study of bladder cancer identifies multiple susceptibility loci
    Nathaniel Rothman
    Division of Cancer Epidemiology and Genetics, National Cancer Institute, Bethesda, Maryland, USA
    Nat Genet 42:978-84. 2010
    ..Our findings on common variants associated with bladder cancer risk should provide new insights into the mechanisms of carcinogenesis...
  12. pmc Genomic DNA hypomethylation as a biomarker for bladder cancer susceptibility in the Spanish Bladder Cancer Study: a case-control study
    Lee E Moore
    Division of Cancer Epidemiology and Genetics, National Cancer Institute, Department of Health and Human Services, Rockville, MD, USA
    Lancet Oncol 9:359-66. 2008
    ..DNA hypomethylation has been suggested to cause genomic instability and increase cancer risk. We aimed to test the hypothesis that DNA hypomethylation is associated with increased risk of bladder cancer...
  13. ncbi Genetic variation in the nucleotide excision repair pathway and bladder cancer risk
    Montserrat Garcia-Closas
    Hormonal and Reproductive Epidemiology Branch, Division of Cancer Epidemiology and Genetics, National Cancer Institute, NIH, Room 7076, 6120 Executive Boulevard, MSC 7234, Rockville, MD 20852 7234, USA
    Cancer Epidemiol Biomarkers Prev 15:536-42. 2006
    ..A detailed characterization of genetic variation in key NER genes is warranted and might ultimately help identify multiple susceptibility variants that could be responsible for substantial joint increases in risk...
  14. doi The TP53 Arg72Pro polymorphism and lung cancer risk in a population of Northern Spain
    Aida Fernández-Rubio
    Departamento de Medicina, Facultad de Medicina, Unidad de Epidemiología Molecular del Instituto Universitario de Oncología, Universidad de Oviedo, 33006 Oviedo, Spain
    Lung Cancer 61:309-16. 2008
    ..56; 95% CI=1.07-2.27). Our results suggest that polymorphism Arg72Pro in tumor suppressor gene TP53 increases the risk of lung cancer. The effect is especially strong for small cell lung cancer (SCLC) and heavy smokers...
  15. ncbi Evaluation of genetic variation in the double-strand break repair pathway and bladder cancer risk
    Jonine D Figueroa
    Division of Cancer Epidemiology and Genetics, National Cancer Institute, Department of Health and Human Services, Bethesda, MD, USA
    Carcinogenesis 28:1788-93. 2007
    ..17 (1.00-1.36). Results from this study provide evidence for associations between variants in genes in the DSBR pathway and bladder cancers risk that warrant replication in other study populations...
  16. ncbi Smoking and bladder cancer in Spain: effects of tobacco type, timing, environmental tobacco smoke, and gender
    Claudine Samanic
    Division of Cancer Epidemiology and Genetics, National Cancer Institute, Department of Health and Human Services, Bethesda, MD 20892, USA
    Cancer Epidemiol Biomarkers Prev 15:1348-54. 2006
    ..2 to 1.7, suggesting that nearly the entire male excess of bladder cancer observed in Spain is explained by cigarette smoking rather than occupational/environmental exposures to other bladder carcinogens...
  17. pmc Bladder cancer risk and genetic variation in AKR1C3 and other metabolizing genes
    Jonine D Figueroa
    Division of Cancer Epidemiology and Genetics, National Cancer Institute, Department of Health and Human Services, Bethesda, MD, USA
    Carcinogenesis 29:1955-62. 2008
    ..These results indicate that genetic variation in carcinogen-metabolizing genes, particularly AKR1C3, could be associated with bladder cancer risk...
  18. pmc Polymorphisms in GSTT1, GSTZ1, and CYP2E1, disinfection by-products, and risk of bladder cancer in Spain
    Kenneth P Cantor
    Division of Cancer Epidemiology and Genetics, National Cancer Institute, Bethesda, Maryland 20892 7240, USA
    Environ Health Perspect 118:1545-50. 2010
    ..Bladder cancer has been linked with long-term exposure to disinfection by-products (DBPs) in drinking water...
  19. pmc Bladder cancer and reproductive factors among women in Spain
    An Tsun Huang
    Department of Health and Human Services, Division of Cancer Epidemiology and Genetics, National Cancer Institute, Bethesda, MD, USA
    Cancer Causes Control 20:1907-13. 2009
    ..Women have a lower risk of bladder cancer than men, and hormonal factors related to childbearing may play a role...
  20. pmc Common genetic variants in the PSCA gene influence gene expression and bladder cancer risk
    Yi Ping Fu
    Laboratory of Translational Genomics, Division of Cancer Epidemiology and Genetics, National Cancer Institute, National Institutes of Health, Bethesda, MD 20892, USA
    Proc Natl Acad Sci U S A 109:4974-9. 2012
    ....
  21. pmc Polymorphism +17 C/G in matrix metalloprotease MMP8 decreases lung cancer risk
    Patricia González-Arriaga
    Departamento de Medicina, Unidad de Epidemiología Molecular del Instituto Universitario de Oncología, Universidad de Oviedo, Oviedo, Spain
    BMC Cancer 8:378. 2008
    ..We have investigated the association between three polymorphisms (-1607 1G/2G, +17 C/G and -77 A/G) in the human collagenases MMP1, MMP8 and MMP13 and the risk of development or progression of lung cancer...
  22. ncbi Genetic variation in the base excision repair pathway and bladder cancer risk
    Jonine D Figueroa
    Division of Cancer Epidemiology and Genetics, Department of Health and Human Services, National Cancer Institute, Bethesda, MD, USA
    Hum Genet 121:233-42. 2007
    ..24 (1.02-1.51) and 1.30 (1.04-1.62), respectively. In summary, data from this large case-control study suggested bladder cancer risk associations with selected BER SNPs, which need to be confirmed in other study populations...
  23. pmc Large-scale evaluation of candidate genes identifies associations between VEGF polymorphisms and bladder cancer risk
    Montserrat Garcia-Closas
    Division of Cancer Epidemiology and Genetics, National Cancer Institute, Department of Health and Human Services, Bethesda, Maryland, United States of America
    PLoS Genet 3:e29. 2007
    ..In conclusion, this large-scale evaluation of candidate cancer genes has identified common genetic variants in the regulatory regions of VEGF that could be associated with bladder cancer risk...
  24. pmc Mapping of the UGT1A locus identifies an uncommon coding variant that affects mRNA expression and protects from bladder cancer
    Wei Tang
    Laboratory of Translational Genomics, Division of Cancer Epidemiology and Genetics, National Cancer Institute, Bethesda, MD 20892, USA
    Hum Mol Genet 21:1918-30. 2012
    ..1 protein. Our study shows an example of genetic and functional role of an uncommon protective genetic variant in a complex human disease, such as bladder cancer...
  25. pmc Urinary pH, cigarette smoking and bladder cancer risk
    Juan Alguacil
    Occupational and Environmental Epidemiology Branch, Division of Cancer Epidemiology and Genetics, National Cancer Institute, Department of Health and Human Services, Bethesda, MD 20892, USA
    Carcinogenesis 32:843-7. 2011
    ..024). These results suggest that urine pH, which is determined primarily by diet and body surface area, may be an important modifier of smoking and risk of bladder cancer...
  26. pmc Common genetic polymorphisms modify the effect of smoking on absolute risk of bladder cancer
    Montserrat Garcia-Closas
    Division of Cancer Epidemiology and Genetics, National Cancer Institute, Bethesda, MD, USA
    Cancer Res 73:2211-20. 2013
    ..Our findings could have implications for targeted prevention strategies. However, other smoking-related diseases, as well as practical and ethical considerations, need to be considered before any recommendations could be made...
  27. pmc Large-scale pathway-based analysis of bladder cancer genome-wide association data from five studies of European background
    Idan Menashe
    Division of Cancer Epidemiology and Genetics, National Cancer Institute, Bethesda, Maryland, United States of America
    PLoS ONE 7:e29396. 2012
    ..Identification of the aromatic amine metabolism pathway provides support for the ability of this approach to identify pathways with established relevance to bladder carcinogenesis...
  28. doi Does increased urination frequency protect against bladder cancer?
    Debra T Silverman
    Division of Cancer Epidemiology and Genetics, National Cancer Institute, Department of Health and Human Services, Bethesda, MD 20892, USA
    Int J Cancer 123:1644-8. 2008
    ..Increased urination frequency, coupled with possible dilution of the urine from increased water intake, may diminish the effect of urinary carcinogens on bladder cancer risk...
  29. ncbi Polymorphisms in one-carbon metabolism and trans-sulfuration pathway genes and susceptibility to bladder cancer
    Lee E Moore
    Division of Cancer Epidemiology and Genetics, National Cancer Institute, National Institutes of Health, Department of Health and Human Services, Rockville, MD, USA
    Int J Cancer 120:2452-8. 2007
    ..Additional work is needed to comprehensively evaluate genomic variation in CTH and related genes in the trans-sulfuration pathway and bladder cancer risk...
  30. pmc The 19q12 bladder cancer GWAS signal: association with cyclin E function and aggressive disease
    Yi Ping Fu
    Laboratory of Translational Genomics, Division of Cancer Epidemiology and Genetics, National Cancer Institute, National Institutes of Health, Bethesda, Maryland
    Cancer Res 74:5808-18. 2014
    ..In combination with established bladder cancer risk factors and other somatic and germline genetic markers, the CCNE1 variants could be useful for inclusion into bladder cancer risk prediction models...
  31. ncbi Educational inequalities in quantity, duration and type of tobacco consumption among lung cancer patients in Asturias: epidemiological analyses
    Alexandra Leader
    Universidad de Oviedo, Facultad de Medicina, Oviedo, Spain
    Psicothema 22:634-40. 2010
    ..72; CI 95%=1.23-11.19). The results show that there are broad educational inequalities with regard to the quantity, duration and type of tobacco consumption among lung cancer patients in Northern Spain...
  32. pmc A genome-wide association study of bladder cancer identifies a new susceptibility locus within SLC14A1, a urea transporter gene on chromosome 18q12.3
    Montserrat Garcia-Closas
    Division of Cancer Epidemiology and Genetics, National Cancer Institute, Bethesda, MD, USA
    Hum Mol Genet 20:4282-9. 2011
    ..Our findings suggest that genetic variation in SLC14A1 could provide new etiological insights into bladder carcinogenesis...
  33. pmc Analysis of Heritability and Shared Heritability Based on Genome-Wide Association Studies for Thirteen Cancer Types
    Joshua N Sampson
    Division of Cancer Epidemiology and Genetics, National Cancer Institute, Bethesda, MD JNS, OP, SIB, QL, CCA, LTA, JDF, MTL, LM, SAS, PRT, KAM, PR, DA, DB, BAB, AB, LBR, WHC, CCC, JSC, JFFJr, NDF, LEBF, MGC, AMG, RNH, NH, WH, PDI, BTJ, CK, Suwon
    J Natl Cancer Inst 107:djv279. 2015
    ..We aim to estimate the heritability and genetic correlation attributable to the additive effects of common single-nucleotide polymorphisms (SNPs) for cancer at 13 anatomical sites...
  34. pmc Identification of a novel susceptibility locus at 13q34 and refinement of the 20p12.2 region as a multi-signal locus associated with bladder cancer risk in individuals of European ancestry
    Jonine D Figueroa
    Division of Cancer Epidemiology and Genetics, National Cancer Institute, Bethesda, MD, USA, Usher Institute of Population Health Sciences and Informatics, Institute of Genetics and Molecular Medicine, University of Edinburgh, Edinburgh, UK
    Hum Mol Genet 25:1203-14. 2016
    ..02 for both rs62185668 and rs6108803). Functional analyses are needed to explore the biological mechanisms underlying these novel genetic associations with risk for bladder cancer. ..
  35. pmc Germ-line mutations in epidermal growth factor receptor (EGFR) are rare but may contribute to oncogenesis: a novel germ-line mutation in EGFR detected in a patient with lung adenocarcinoma
    Irene Centeno
    Laboratorio de Oncologia Molecular, Instituto Universitario de Oncologia del Principado de Asturias, Hospital Universitario Central de Asturias, Celestino Villamil s n, Oviedo, Spain
    BMC Cancer 11:172. 2011
    ..3) To determine whether the novel mutation detected may have a functional effect on the EGFR protein...
  36. pmc Imputation and subset-based association analysis across different cancer types identifies multiple independent risk loci in the TERT-CLPTM1L region on chromosome 5p15.33
    Zhaoming Wang
    Division of Cancer Epidemiology and Genetics, Cancer Genomics Research Laboratory, National Cancer Institute, Division of Cancer Epidemiology and Genetics, SAIC Frederick, Inc, Frederick National Laboratory for Cancer Research, Frederick, MD, USA
    Hum Mol Genet 23:6616-33. 2014
    ..33. Our results provide strong support for extensive pleiotropy across this region of 5p15.33, to an extent not previously observed in other cancer susceptibility loci. ..
  37. pmc NAT2 slow acetylation, GSTM1 null genotype, and risk of bladder cancer: results from the Spanish Bladder Cancer Study and meta-analyses
    Montserrat Garcia-Closas
    Division of Cancer Epidemiology and Genetics, National Cancer Institute, Department of Health and Human Services, Bethesda, MD 20852 7234, USA
    Lancet 366:649-59. 2005
    ..Associations between polymorphisms in other NAT and GST genes and bladder-cancer risk have been inconsistent...
  38. ncbi Air pollution and risk of urinary bladder cancer in a case-control study in Spain
    Gemma Castano-Vinyals
    Gemma Castaño Vinyals, Centre for Research in Environmental Epidemiology CREAL, Municipal Institute of Medical Research, C Doctor Aiguader, 88, Barcelona 08003, Spain
    Occup Environ Med 65:56-60. 2008
    ..Air pollution has been associated with an increased risk for lung cancer. We examined whether long-term air pollution is associated with bladder cancer risk...
  39. ncbi Hair dye use is not associated with risk for bladder cancer: evidence from a case-control study in Spain
    Manolis Kogevinas
    Municipal Institute of Medical Research, Centre for Research in Environmental Epidemiology CREAL, Respiratory and Environmental Health Research Unit, Dr Aiguader 80, 08003 Barcelona, Spain
    Eur J Cancer 42:1448-54. 2006
    ..None of the polymorphisms examined significantly modified the hair dye associated risk. Overall, this study does not support an association between hair dye use and bladder cancer...
  40. ncbi Bladder cancer and exposure to water disinfection by-products through ingestion, bathing, showering, and swimming in pools
    Cristina M Villanueva
    Centre for Research in Environmental Epidemiology, Municipal Institute of Medical Research, Barcelona, Spain
    Am J Epidemiol 165:148-56. 2007
    ..57 (95% confidence interval: 1.18, 2.09). Bladder cancer risk was associated with long-term exposure to THMs in chlorinated water at levels regularly occurring in industrialized countries...
  41. pmc Total fluid and water consumption and the joint effect of exposure to disinfection by-products on risk of bladder cancer
    Dominique S Michaud
    Department of Epidemiology, Harvard School of Public Health, Boston, Massachusetts 02115, USA
    Environ Health Perspect 115:1569-72. 2007
    ..A pooled analysis based on six case-control studies observed a positive association between tap water and bladder cancer but none for nontap fluid intake, suggesting that contaminants in tap water may be responsible for the excess risk...
  42. ncbi The Spanish Environment and Childhood Research Network (INMA study)
    Mariana F Fernandez
    Hospital Universitario San Cecilio, Granada, Spain
    Int J Hyg Environ Health 210:491-3. 2007
    ....
  43. ncbi Bulky DNA adduct formation and risk of bladder cancer
    Gemma Castano-Vinyals
    Centre for Research in Environmental Epidemiology, Institut Municipal d Investigacio Medica, Doctor Aiguader, 88, 08003 Barcelona, Spain
    Cancer Epidemiol Biomarkers Prev 16:2155-9. 2007
    ..Results do not support an association of bladder cancer risk with low-level exposure to PAHs as measured through the formation of bulky DNA adducts in peripheral mononuclear cells...