XOSE BUSTELO

Summary

Affiliation: Universidad de Salamanca
Country: Spain

Publications

  1. pmc VAV3 mediates resistance to breast cancer endocrine therapy
    Helena Aguilar
    Breast Cancer Res 16:R53. 2014
  2. doi New avenue to inhibit Ras signaling
    Xose R Bustelo
    Centro de Investigacion del Cancer, Consejo Superior de Investigaciones Científicas and University of Salamanca, Campus Unamuno, 37007 Salamanca, Spain Instituto de Biología Molecular y Celular del Cáncer, Consejo Superior de Investigaciones Científicas and University of Salamanca, Campus Unamuno, 37007 Salamanca, Spain Electronic address
    Chem Biol 21:1599-600. 2014
  3. pmc The Rho exchange factors Vav2 and Vav3 favor skin tumor initiation and promotion by engaging extracellular signaling loops
    Mauricio Menacho-Marquez
    Centro de Investigacion del Cancer, Consejo Superior de Investigaciones Cientificas CSIC University of Salamanca, Salamanca, Spain
    PLoS Biol 11:e1001615. 2013
  4. pmc Vav3 is involved in GABAergic axon guidance events important for the proper function of brainstem neurons controlling cardiovascular, respiratory, and renal parameters
    Vincent Sauzeau
    Centro de Investigacion del Cancer, CSIC Salamanca University, Instituto de Neurociencias de Castilla y León and Departamento de Fisiología y Farmacología, Salamanca University, 37007 Salamanca, Spain
    Mol Biol Cell 21:4251-63. 2010
  5. pmc A transcriptional cross-talk between RhoA and c-Myc inhibits the RhoA/Rock-dependent cytoskeleton
    V Sauzeau
    Centro de Investigacion del Cancer, CSIC University of Salamanca, Campus Unamuno, Salamanca, Spain
    Oncogene 29:3781-92. 2010
  6. pmc The use of knockout mice reveals a synergistic role of the Vav1 and Rasgrf2 gene deficiencies in lymphomagenesis and metastasis
    Sergio Ruiz
    Centro de Investigación del Cáncer and Instituto de Biología Molecular y Celular del Cáncer, Consejo Superior de Investigaciones Científicas University of Salamanca, Salamanca, Spain
    PLoS ONE 4:e8229. 2009
  7. pmc The Gammaherpesvirus m2 protein manipulates the Fyn/Vav pathway through a multidocking mechanism of assembly
    Marta Pires de Miranda
    Instituto de Microbiologia e Instituto de Medicina Molecular, Faculdade de Medicina, Universidade de Lisboa, Lisboa, Portugal
    PLoS ONE 3:e1654. 2008
  8. pmc Rac-ing to the plasma membrane: the long and complex work commute of Rac1 during cell signaling
    Xose R Bustelo
    Centro de Investigacion del Cancer, Instituto de Biologia Molecular y Celular del Cancer, CSIC University of Salamanca, Campus Unamuno, Salamanca, Spain
    Small Gtpases 3:60-6. 2012
  9. doi Intratumoral stages of metastatic cells: a synthesis of ontogeny, Rho/Rac GTPases, epithelial-mesenchymal transitions, and more
    Xose R Bustelo
    Centro de Investigación del Cáncer and Instituto de Biología Molecular y Celular del Cáncer, CSIC University of Salamanca, Salamanca, Spain
    Bioessays 34:748-59. 2012
  10. pmc GTP-binding proteins of the Rho/Rac family: regulation, effectors and functions in vivo
    Xose R Bustelo
    Centro de Investigación del Cáncer and Instituto de Biología Molecular y Celular del Cáncer IBMCC, CSIC University of Salamanca, Salamanca, Spain
    Bioessays 29:356-70. 2007

Research Grants

Collaborators

  • Balbino Alarcon
  • Beatriz Rico
  • Yixian Zheng
  • J Pedro Simas
  • Jesus M Paramio
  • Eugenio Santos
  • I M Berenjeno
  • Sergio Ruiz
  • Helena Aguilar
  • Mauricio Menacho-Marquez
  • Pilar Delgado
  • V Sauzeau
  • Vincent Sauzeau
  • Maria Jose Caloca
  • Marta Pires de Miranda
  • R M Prieto-Sánchez
  • Maurice P H M Jansen
  • Robert Clarke
  • Joan Brunet
  • Ander Urruticoechea
  • Olle Stal
  • Alberto Villanueva
  • Laia Gómez-Baldó
  • Alejo Rodriguez-Vida
  • Miguel Vizoso
  • Ekaterina Nevedomskaya
  • Dennis C Sgroi
  • Josep Balart
  • N ria Bonifaci
  • Mar a Teresa Soler
  • Gizeh Pérez Tenorio
  • Ana I Extremera
  • Yusuke Nakamura
  • Livia Caizzi
  • Kathryn E Carlson
  • Roderick L Beijersbergen
  • Hitoshi Zembutsu
  • Pasi Halonen
  • Jordi Serra-Musach
  • Elin Karlsson
  • Ana B Rodríguez-Peña
  • Abul Islam
  • Taisei Mushiroda
  • Rafael Garcia-Mata
  • Miguel Angel Pujana
  • Wilbert Zwart
  • Kerry L Burnstein
  • Manel Esteller
  • Josefine Bostner
  • Tommy Fornander
  • Agnes Figueras
  • John A Katzenellenbogen
  • Griselda Martrat
  • Miguel Gil
  • Nadia Garcia
  • Fina Climent
  • Kazuma Kiyotani
  • Xavier Barril
  • Luciano Di Croce
  • Clotilde Costa
  • Ramón García-Escudero
  • Antonio Abad
  • Virginia Ojeda
  • N Movilla
  • José A C Horta-Junior
  • Gloria Fernandez
  • Maria A Sevilla
  • Dolores E López
  • María J Montero
  • C Citterio
  • Adelaida S Riolobos
  • Lénia Rodrigues
  • Filipa Lopes
  • Marta Alenquer
  • Sofia Marques
  • F Nunez
  • M Dosil

Detail Information

Publications18

  1. pmc VAV3 mediates resistance to breast cancer endocrine therapy
    Helena Aguilar
    Breast Cancer Res 16:R53. 2014
    ..However, most tumors initially responsive to these therapies acquire resistance through mechanisms that involve ERα transcriptional regulatory plasticity. Herein we identify VAV3 as a critical component in this process...
  2. doi New avenue to inhibit Ras signaling
    Xose R Bustelo
    Centro de Investigacion del Cancer, Consejo Superior de Investigaciones Científicas and University of Salamanca, Campus Unamuno, 37007 Salamanca, Spain Instituto de Biología Molecular y Celular del Cáncer, Consejo Superior de Investigaciones Científicas and University of Salamanca, Campus Unamuno, 37007 Salamanca, Spain Electronic address
    Chem Biol 21:1599-600. 2014
    ..In this issue of Chemistry & Biology, Evelyn and coworkers report an inhibitor for one such enzyme, Sos1, capable of impairing wild-type Ras signaling in cells. ..
  3. pmc The Rho exchange factors Vav2 and Vav3 favor skin tumor initiation and promotion by engaging extracellular signaling loops
    Mauricio Menacho-Marquez
    Centro de Investigacion del Cancer, Consejo Superior de Investigaciones Cientificas CSIC University of Salamanca, Salamanca, Spain
    PLoS Biol 11:e1001615. 2013
    ..They also suggest that anti-Vav therapies may be of potential interest in skin tumor prevention and/or treatment. ..
  4. pmc Vav3 is involved in GABAergic axon guidance events important for the proper function of brainstem neurons controlling cardiovascular, respiratory, and renal parameters
    Vincent Sauzeau
    Centro de Investigacion del Cancer, CSIC Salamanca University, Instituto de Neurociencias de Castilla y León and Departamento de Fisiología y Farmacología, Salamanca University, 37007 Salamanca, Spain
    Mol Biol Cell 21:4251-63. 2010
    ..Our study discloses an essential and nonredundant role for this Vav family member in axon guidance events in brainstem neurons that control blood pressure and respiratory rates...
  5. pmc A transcriptional cross-talk between RhoA and c-Myc inhibits the RhoA/Rock-dependent cytoskeleton
    V Sauzeau
    Centro de Investigacion del Cancer, CSIC University of Salamanca, Campus Unamuno, Salamanca, Spain
    Oncogene 29:3781-92. 2010
    ..These results reveal the presence of a hitherto unknown signaling feed-back loop between RhoA and c--Myc oncogenes that can contribute to maintain fluid cytoskeletal dynamics in cancer cells...
  6. pmc The use of knockout mice reveals a synergistic role of the Vav1 and Rasgrf2 gene deficiencies in lymphomagenesis and metastasis
    Sergio Ruiz
    Centro de Investigación del Cáncer and Instituto de Biología Molecular y Celular del Cáncer, Consejo Superior de Investigaciones Científicas University of Salamanca, Salamanca, Spain
    PLoS ONE 4:e8229. 2009
    ..Vav1 and RasGRF2 are GDP/GTP exchange factors for Ras superfamily GTPases with roles in the development and/or effector functions of T-lymphocytes...
  7. pmc The Gammaherpesvirus m2 protein manipulates the Fyn/Vav pathway through a multidocking mechanism of assembly
    Marta Pires de Miranda
    Instituto de Microbiologia e Instituto de Medicina Molecular, Faculdade de Medicina, Universidade de Lisboa, Lisboa, Portugal
    PLoS ONE 3:e1654. 2008
    ..Taken together, these results indicate that the M2 phosphotyrosine motif and the previously described M2 proline rich region work in a concerted manner to manipulate the signaling machinery of the host B-cell...
  8. pmc Rac-ing to the plasma membrane: the long and complex work commute of Rac1 during cell signaling
    Xose R Bustelo
    Centro de Investigacion del Cancer, Instituto de Biologia Molecular y Celular del Cancer, CSIC University of Salamanca, Campus Unamuno, Salamanca, Spain
    Small Gtpases 3:60-6. 2012
    ..This pathway is important for optimal Rac1 activation during the signaling of the EGF receptor, integrins, and the antigenic T-cell receptor...
  9. doi Intratumoral stages of metastatic cells: a synthesis of ontogeny, Rho/Rac GTPases, epithelial-mesenchymal transitions, and more
    Xose R Bustelo
    Centro de Investigación del Cáncer and Instituto de Biología Molecular y Celular del Cáncer, CSIC University of Salamanca, Salamanca, Spain
    Bioessays 34:748-59. 2012
    ..Finally, the therapeutic and diagnostic relevance of this information will be discussed, as well as potential future developments...
  10. pmc GTP-binding proteins of the Rho/Rac family: regulation, effectors and functions in vivo
    Xose R Bustelo
    Centro de Investigación del Cáncer and Instituto de Biología Molecular y Celular del Cáncer IBMCC, CSIC University of Salamanca, Salamanca, Spain
    Bioessays 29:356-70. 2007
    ..In this review, we will provide an overview on the recent advances in this field regarding the mechanism of regulation and signaling, and the roles in vivo of this important GTPase family...
  11. ncbi Regulation of Vav proteins by intramolecular events
    Xose R Bustelo
    Centro de Investigacion del Cáncer and Instituto de Biologia Molecular y Celular del Cáncer University of Salamanca CSIC 37007 Salamanca, Spain
    Front Biosci 7:d24-30. 2002
    ..In this review, we will give a brief overview of the recent advances in this field...
  12. ncbi Understanding Rho/Rac biology in T-cells using animal models
    Xose R Bustelo
    Centro de Investigacion del Cancer, Instituto de Biologia Molecular y Celular del Cancer, University of Salamanca CSIC 37007 Salamanca, Spain
    Bioessays 24:602-12. 2002
    ..Moreover, these animals have revealed interesting cross-talks between Rho/Rac pathways and other signal transduction routes that participate in lymphocyte responses...
  13. ncbi Knocked out by Rho/Rac T-cell biology
    X R Bustelo
    Centro de Investigación del Cáncer and Instituto de Biología Molecular y Celular del Cáncer, CSIC University of Salamanca, Spain
    Histol Histopathol 17:871-5. 2002
    ....
  14. pmc Role of chimaerins, a group of Rac-specific GTPase activating proteins, in T-cell receptor signaling
    Maria Jose Caloca
    Centro de Investigación del Cáncer and Instituto de Biología Molecular y Celular del Cáncer, CSIC University of Salamanca, Campus Unamuno, E 37007 Salamanca, Spain
    Cell Signal 20:758-70. 2008
    ..Taken together, these results identify chimaerins as candidates for the downmodulation of Rac1 in T-lymphocytes and, in addition, uncover a novel regulatory mechanism that mediates their activation in T-cells...
  15. ncbi Vav proteins, adaptors and cell signaling
    X R Bustelo
    Centro de Investigación del Cáncer and Instituto de Biología Molecular y Celular del Cáncer, CSIC University of Salamanca, Campus Unamuno, 37007 Salamanca, Spain
    Oncogene 20:6372-81. 2001
    ..In this review, we will give a summary of the recent advances in this field, placing special emphasis on the non-catalytic roles of Vav and its interaction with other adaptor molecules...
  16. ncbi How Vav proteins discriminate the GTPases Rac1 and RhoA from Cdc42
    N Movilla
    , University of Salamanca-CSIC, 37007 Salamanca, Spain
    Oncogene 20:8057-65. 2001
    ....
  17. pmc Involvement of the Rho/Rac family member RhoG in caveolar endocytosis
    R M Prieto-Sánchez
    Centro de Investigacion del Cancer, Instituto de Biología Molecular y Celular del Cáncer IBMCC, and Red Temática Cooperativa de Centros de Cáncer, CSIC University of Salamanca, Spain
    Oncogene 25:2961-73. 2006
    ..Taken together, these observations assign a novel function to RhoG and suggest that caveolar trafficking, as previously shown for other endocytic routes, is modulated by GTPases of the Ras superfamily...
  18. pmc Transcriptomal profiling of the cellular transformation induced by Rho subfamily GTPases
    I M Berenjeno
    Centro de Investigación del Cáncer and Instituto de Biología Molecular y Celular del Cáncer IBMCC, CSIC University of Salamanca, Campus Unamuno, Salamanca, Spain
    Oncogene 26:4295-305. 2007
    ..These results reveal the complexity of the genetic program orchestrated by the Rho subfamily and pinpoint protein networks that mediate different aspects of the malignant phenotype of Rho-transformed cells...

Research Grants1

  1. Role of Vav family proteins in cell signaling and cancer
    XOSE BUSTELO; Fiscal Year: 2009
    ..abstract_text> ..