Tomas Sobrino

Summary

Country: Spain

Publications

  1. doi request reprint Cd34+ progenitor cells likely are involved in the good functional recovery after intracerebral hemorrhage in humans
    Tomas Sobrino
    Department of Neurology, Clinical Neurosciences Research Laboratory, Hospital Clinico Universitario, IDIS, University of Santiago de Compostela, Santiago de Compostela, Spain
    J Neurosci Res 89:979-85. 2011
  2. pmc Association between neuroserpin and molecular markers of brain damage in patients with acute ischemic stroke
    Raquel Rodríguez-González
    Clinical Neuroscience Research Laboratory, Department of Neurology, Hospital Clinico Universitario, University of Santiago de Compostela, Santiago de Compostela, Spain
    J Transl Med 9:58. 2011
  3. ncbi request reprint High blood pressure and inflammation are associated with poor prognosis in lacunar infarctions
    Miguel Blanco
    Stroke Unit and Neurovascular Research Laboratory, Department of Neurology, Hospital Clinico Universitario, University of Santiago de Compostela, Santiago de Compostela, Spain
    Cerebrovasc Dis 22:123-9. 2006
  4. doi request reprint A higher body temperature is associated with haemorrhagic transformation in patients with acute stroke untreated with recombinant tissue-type plasminogen activator (rtPA)
    Rogelio Leira
    Department of Neurology, Clinical Neurosciences Research Laboratory, Hospital Clinico Universitario, University of Santiago de Compostela, Spain
    Clin Sci (Lond) 122:113-9. 2012
  5. doi request reprint Early biomarkers of clinical-diffusion mismatch in acute ischemic stroke
    Manuel Rodríguez-Yáñez
    Neurovascular ARea, Department of Neurology, Clinical Neurosciences Research Laboratory, Hospital Clinico Universitario, University of Santiago de Comostela, Santiago de Compostela, Spain
    Stroke 42:2813-8. 2011
  6. doi request reprint High serum levels of endothelin-1 predict severe cerebral edema in patients with acute ischemic stroke treated with t-PA
    Octavio Moldes
    Department of Neurology, Clinical Neuroscience Research Laboratory, Hospital Clinico Universitario, University of Santiago de Compostela, Santiago de Compostela, Spain
    Stroke 39:2006-10. 2008
  7. doi request reprint Toll-like receptors 7 and 8 expression is associated with poor outcome and greater inflammatory response in acute ischemic stroke
    David Brea
    Clinical Neuroscience Research Laboratory, Department of Neurology, Hospital Clinico Universitario, University of Santiago de Compostela, Santiago de Compostela, Spain
    Clin Immunol 139:193-8. 2011
  8. pmc Neuroprotection by glutamate oxaloacetate transaminase in ischemic stroke: an experimental study
    Francisco Campos
    Department of Neurology, Clinical Neuroscience Research Laboratory, Hospital Clinico Universitario, University of Santiago de Compostela, IDIS, Santiago de Compostela, Spain
    J Cereb Blood Flow Metab 31:1378-86. 2011
  9. pmc Hyperthermia in human ischemic and hemorrhagic stroke: similar outcome, different mechanisms
    Francisco Campos
    Department of Neurology, Neurovascular ARea, Clinical Neurosciences Research Laboratory, Hospital Clinico Universitario, Health Research Institute of Santiago de Compostela IDIS, University of Santiago de Compostela, Santiago de Compostela, Spain
    PLoS ONE 8:e78429. 2013
  10. pmc A polymorphism in the EAAT2 promoter is associated with higher glutamate concentrations and higher frequency of progressing stroke
    Judith Mallolas
    Department of Neurology, Hospital Universitario Doctor Josep Trueta, 17007 Girona, Spain
    J Exp Med 203:711-7. 2006

Collaborators

Detail Information

Publications50

  1. doi request reprint Cd34+ progenitor cells likely are involved in the good functional recovery after intracerebral hemorrhage in humans
    Tomas Sobrino
    Department of Neurology, Clinical Neurosciences Research Laboratory, Hospital Clinico Universitario, IDIS, University of Santiago de Compostela, Santiago de Compostela, Spain
    J Neurosci Res 89:979-85. 2011
    ..038) at 72 hr showed a strong correlation with CD34(+) progenitor cell levels at day 7. These findings suggest that CD34(+) progenitor cells may participate in the functional recovery of ICH patients...
  2. pmc Association between neuroserpin and molecular markers of brain damage in patients with acute ischemic stroke
    Raquel Rodríguez-González
    Clinical Neuroscience Research Laboratory, Department of Neurology, Hospital Clinico Universitario, University of Santiago de Compostela, Santiago de Compostela, Spain
    J Transl Med 9:58. 2011
    ..Our aim was to study whether neuroserpin serum levels could be associated to biomarkers of excitotoxicity, inflammation and blood brain barrier disruption...
  3. ncbi request reprint High blood pressure and inflammation are associated with poor prognosis in lacunar infarctions
    Miguel Blanco
    Stroke Unit and Neurovascular Research Laboratory, Department of Neurology, Hospital Clinico Universitario, University of Santiago de Compostela, Santiago de Compostela, Spain
    Cerebrovasc Dis 22:123-9. 2006
    ..In this study we sought to investigate the factors associated with poor outcome in patients with lacunar infarction...
  4. doi request reprint A higher body temperature is associated with haemorrhagic transformation in patients with acute stroke untreated with recombinant tissue-type plasminogen activator (rtPA)
    Rogelio Leira
    Department of Neurology, Clinical Neurosciences Research Laboratory, Hospital Clinico Universitario, University of Santiago de Compostela, Spain
    Clin Sci (Lond) 122:113-9. 2012
    ..In conclusion, high body temperature within the first 24 h after ischaemic stroke is a risk factor for HT in patients untreated with rtPA. This effect is independent of some biological signatures of BBB damage...
  5. doi request reprint Early biomarkers of clinical-diffusion mismatch in acute ischemic stroke
    Manuel Rodríguez-Yáñez
    Neurovascular ARea, Department of Neurology, Clinical Neurosciences Research Laboratory, Hospital Clinico Universitario, University of Santiago de Comostela, Santiago de Compostela, Spain
    Stroke 42:2813-8. 2011
    ..Our aim was to identify early biomarkers associated with the presence of CDM...
  6. doi request reprint High serum levels of endothelin-1 predict severe cerebral edema in patients with acute ischemic stroke treated with t-PA
    Octavio Moldes
    Department of Neurology, Clinical Neuroscience Research Laboratory, Hospital Clinico Universitario, University of Santiago de Compostela, Santiago de Compostela, Spain
    Stroke 39:2006-10. 2008
    ..In this study we analyze the association between high serum levels of ET-1 and the development of severe cerebral edema in patients treated with t-PA...
  7. doi request reprint Toll-like receptors 7 and 8 expression is associated with poor outcome and greater inflammatory response in acute ischemic stroke
    David Brea
    Clinical Neuroscience Research Laboratory, Department of Neurology, Hospital Clinico Universitario, University of Santiago de Compostela, Santiago de Compostela, Spain
    Clin Immunol 139:193-8. 2011
    ..In conclusion, TLR 7 and TLR8 expressions are associated with poor outcome and greater inflammatory response in acute ischemic stroke...
  8. pmc Neuroprotection by glutamate oxaloacetate transaminase in ischemic stroke: an experimental study
    Francisco Campos
    Department of Neurology, Clinical Neuroscience Research Laboratory, Hospital Clinico Universitario, University of Santiago de Compostela, IDIS, Santiago de Compostela, Spain
    J Cereb Blood Flow Metab 31:1378-86. 2011
    ..These findings show the capacity of the GOT to remove glutamate from the brain by means of blood glutamate degradation, and suggest the applicability of this enzyme as an efficient and novel neuroprotective tool against ischemic stroke...
  9. pmc Hyperthermia in human ischemic and hemorrhagic stroke: similar outcome, different mechanisms
    Francisco Campos
    Department of Neurology, Neurovascular ARea, Clinical Neurosciences Research Laboratory, Hospital Clinico Universitario, Health Research Institute of Santiago de Compostela IDIS, University of Santiago de Compostela, Santiago de Compostela, Spain
    PLoS ONE 8:e78429. 2013
    ..29; 95% CI, 1.13-1.49; p<0.0001) in ICH. In conclusion, these results suggest that although the outcome associated to hyperthermia is similar in human IS and ICH, the underlying mechanisms may be different. ..
  10. pmc A polymorphism in the EAAT2 promoter is associated with higher glutamate concentrations and higher frequency of progressing stroke
    Judith Mallolas
    Department of Neurology, Hospital Universitario Doctor Josep Trueta, 17007 Girona, Spain
    J Exp Med 203:711-7. 2006
    ..These findings may explain individual susceptibility to excitotoxic damage after stroke as well as the failure of glutamate antagonists in those patients without this polymorphism...
  11. pmc High blood glutamate oxaloacetate transaminase levels are associated with good functional outcome in acute ischemic stroke
    Francisco Campos
    Clinical Neuroscience Research Laboratory, Department of Neurology, Hospital Clinico Universitario, University of Santiago de Compostela, IDIS, Santiago de Compostela, Spain
    J Cereb Blood Flow Metab 31:1387-93. 2011
    ..These findings show a clear association between high blood glutamate levels and worse outcome and vice versa for GOT, presumably explained by the capacity of this enzyme to metabolize blood glutamate...
  12. doi request reprint The natural tissue plasminogen activator inhibitor neuroserpin and acute ischaemic stroke outcome
    Raquel Rodríguez-González
    Department of Neurology, Hospital Clinico Universitario, Universidad de Santiago de Compostela, Santiago de Compostela, Spain
    Thromb Haemost 105:421-9. 2011
    ..These findings support the concept that neuroserpin might play an important role during cerebral ischaemia...
  13. ncbi request reprint Evolving paradigms for neuroprotection: molecular identification of ischemic penumbra
    Mar Castellanos
    Department of Neurology, Hospital Universitari Doctor Josep Trueta, Girona, Spain
    Cerebrovasc Dis 21:71-9. 2006
    ....
  14. doi request reprint CDP-choline treatment increases circulating endothelial progenitor cells in acute ischemic stroke
    Tomas Sobrino
    Clinical Neuroscience Research Laboratory, Department of Neurology, Hospital Clinico Universitario, IDIS, University of Santiago de Compostela, Spain
    Neurol Res 33:572-7. 2011
    ..CDP-choline (citicoline) increases brain plasticity after experimental stroke. Therefore, we study if citicoline treatment could increase the EPC concentration after ischemic stroke...
  15. doi request reprint Blood levels of glutamate oxaloacetate transaminase are more strongly associated with good outcome in acute ischaemic stroke than glutamate pyruvate transaminase levels
    Francisco Campos
    Department of Neurology Stroke Unit, Clinical Neurosciences Research Laboratory, Hospital Clinico Universitario, University of Santiago de Compostela, Spain
    Clin Sci (Lond) 121:11-7. 2011
    ..7 compared with 18.1±10.8 m-units/ml; P<0.0001). This clinical study shows an association between high blood GOT and GPT levels and good outcome in ischaemic stroke patients, this association being stronger for GOT than GPT levels...
  16. pmc Toll-like receptors 2 and 4 in ischemic stroke: outcome and therapeutic values
    David Brea
    Department of Neurology, Clinical Neurosciences Research Laboratory, Hospital Clinico Universitario, University of Santiago de Compostela, Santiago de Compostela, Spain
    J Cereb Blood Flow Metab 31:1424-31. 2011
    ..In conclusion, TLR2 and TLR4 are associated to outcome in stroke patients and TLR2/4 or their endogenous ligands, cFN/HSP60 could be new therapeutic targets for ischemic stroke...
  17. doi request reprint Glutamate oxaloacetate transaminase: a new key in the dysregulation of glutamate in migraine patients
    Francisco Campos
    Department of Neurology, Neurovascular ARea, Clinical Neurosciences Research Laboratory, Hospital Clinico Universitario, Institute for Sanitary Research of Santiago de Compostela IDIS, University of Santiago de Compostela, Spain
    Cephalalgia 33:1148-54. 2013
    ....
  18. ncbi request reprint Ischemic preconditioning: a novel target for neuroprotective therapy
    Miguel Blanco
    Department of Neurology, Division of Vascular Neurology, Laboratory of Neurovascular Research, Hospital Clinico Universitario, University of Santiago de Compostela, Spain
    Cerebrovasc Dis 21:38-47. 2006
    ....
  19. doi request reprint Temporal profile of molecular signatures associated with circulating endothelial progenitor cells in human ischemic stroke
    Tomas Sobrino
    Department of Neurology, Clinical Neurosciences Research Laboratory, Hospital Clinico Universitario, IDIS, University of Santiago de Compostela, Santiago de Compostela, Spain
    J Neurosci Res 90:1788-93. 2012
    ..0001) and SDF-1α at 24 hr (B: 0.049, P = 0.008) were independent factors for EPC increment during the first week of evolution. These findings suggest that VEGF and SDF-1α may mediate EPC proliferation in human ischemic stroke...
  20. doi request reprint Proteomic analysis shows differential protein expression in endothelial progenitor cells between healthy subjects and ischemic stroke patients
    David Brea
    Hospital Clinico Universitario, IDIS, University of Santiago de Compostela, Spain
    Neurol Res 33:1057-63. 2011
    ..Likewise, EPCs are heterogeneous cells, with functional differences and different protein expressions. Our objective was to compare protein expressions of EPCs from ischemic stroke patients and healthy subjects...
  21. ncbi request reprint The increase of circulating endothelial progenitor cells after acute ischemic stroke is associated with good outcome
    Tomas Sobrino
    Clinical Neuroscience Research Laboratory, Department of Neurology, Hospital Clinico Universitario, University of Santiago de Compostela, Santiago de Compostela, Spain
    Stroke 38:2759-64. 2007
    ..The present study was designed to evaluate the prognostic value of EPC in acute ischemic stroke...
  22. doi request reprint Temporal profile and clinical significance of serum neuron-specific enolase and S100 in ischemic and hemorrhagic stroke
    David Brea
    Department of Neurology, Clinical Neuroscience Research Laboratory, Hospital Clinico Universitario, University of Santiago de Compostela, Santiago de Compostela, Spain
    Clin Chem Lab Med 47:1513-8. 2009
    ..Our objective was to analyze the temporal profile and the clinical significance of NSE and S-100 in acute ischemic (IS) and intracerebral hemorrhage (ICH)...
  23. doi request reprint Usefulness of haptoglobin and serum amyloid A proteins as biomarkers for atherothrombotic ischemic stroke diagnosis confirmation
    David Brea
    Department of Neurology, Hospital Clinico Universitario, University of Santiago de Compostela, Spain
    Atherosclerosis 205:561-7. 2009
    ..To identify protein biomarkers in order to classify ischemic stroke subtypes using proteomic analysis and immunoenzymatic tools for clinical validation...
  24. pmc High serum levels of pro-brain natriuretic peptide (pro BNP) identify cardioembolic origin in undetermined stroke
    Manuel Rodríguez-Yáñez
    Clinical Neuroscience Research Laboratory, Department of Neurology, Hospital Clinico Universitario, University of Santiago de Compostela, Santiago de Compostela, Spain
    Dis Markers 26:189-95. 2009
    ....
  25. doi request reprint High pro-BNP levels predict the occurrence of atrial fibrillation after cryptogenic stroke
    Manuel Rodríguez-Yáñez
    Clinical Neuroscience Research Laboratory, Department of Neurology, Hospital Clinico Universitario, Health Research Institute of Santiago de Compostela IDIS, University of Santiago de Compostela, Santiago de Compostela, Spain
    Neurology 81:444-7. 2013
    ....
  26. doi request reprint Platelet derived growth factor-CC isoform is associated with hemorrhagic transformation in ischemic stroke patients treated with tissue plasminogen activator
    Raquel Rodríguez-González
    Clinical Neurosciences Research Laboratory, Neurovascular ARea, Department of Neurology, Hospital Clinico Universitario, IDIS, University of Santiago de Compostela, Santiago de Compostela, Spain
    Atherosclerosis 226:165-71. 2013
    ..We aimed to study the association of PDGF isoforms serum levels with hemorrhagic transformation (HT) and edema after thrombolytic treatment in ischemic stroke...
  27. doi request reprint Neuroprotection afforded by antagonists of endothelin-1 receptors in experimental stroke
    Octavio Moldes
    Clinical Neurosciences Research Laboratory, Neurovascular ARea, Department of Neurology, Hospital Clinico Universitario, IDIS, University of Santiago de Compostela, Santiago de Compostela, Spain
    Neuropharmacology 63:1279-85. 2012
    ..01). Moreover, Clazosentan® induced a decrease in AQP4 expression, while BQ-788 induced an increase in AQP9 expression. These results suggest that antagonists for ET-1 receptors may be a good therapeutic target for cerebral ischemia...
  28. doi request reprint Endothelial progenitor cells: a new key for endothelial dysfunction in migraine
    Xiana Rodríguez-Osorio
    Department of Neurology, Hospital Clinico Universitario, Universidad de Santiago de Compostela, Santiago de Compostela, Spain
    Neurology 79:474-9. 2012
    ..We aimed to study endothelial function with biochemical and ultrasonographic markers and its relation with endothelial progenitor cells (EPCs) in patients with migraine...
  29. doi request reprint Oxaloacetate: a novel neuroprotective for acute ischemic stroke
    Francisco Campos
    Clinical Neurosciences Research Laboratory, Department of Neurology, Hospital Clinico Universitario, IDIS, University of Santiago de Compostela, 15706 Santiago de Compostela, Spain
    Int J Biochem Cell Biol 44:262-5. 2012
    ..Here we review the recent experimental and clinical results where it is demonstrated the potential applicability of oxaloacetate as a novel and powerful neuroprotective treatment against ischemic stroke...
  30. doi request reprint Increased expression of Toll-like receptors 2 and 4 is associated with poor outcome in intracerebral hemorrhage
    Manuel Rodríguez-Yáñez
    Clinical Neurosciences Research Laboratory, Department of Neurology, Hospital Clinico Universitario, University of Santiago de Compostela, Santiago de Compostela, Spain
    J Neuroimmunol 247:75-80. 2012
    ..In conclusion, increased expression of TLR2 and TLR4 is associated with poor functional outcome and greater residual volume in ICH patients...
  31. doi request reprint High serum levels of growth factors are associated with good outcome in intracerebral hemorrhage
    Tomas Sobrino
    Clinical Neuroscience Research Laboratory, Hospital Clinico Universitario, Santiago de Compostela, Spain
    J Cereb Blood Flow Metab 29:1968-74. 2009
    ..0001) and reduced residual cavity at 3 months (all P<0.01). These results illustrate that high serum levels of GF are associated with good functional outcome and reduced lesion volume in ICH...
  32. pmc Study of Protein Expression in Peri-Infarct Tissue after Cerebral Ischemia
    David Brea
    1 Neurology Department, Neurovascular ARea, Clinical Neurosciences Research Laboratory, University Clinical Hospital, Health Research Institute of Santiago de Compostela IDIS, University of Santiago de Compostela, Spain 2 Cellular and Molecular Neurobiology Research Group and Grup de Recerça en Neurociencies del IGTP, Department of Neurosciences, Fundació Institut d Investigació en Ciències de la Salut Germans Trias I Pujol Universitat Autónoma de Barcelona, Badalona, Spain
    Sci Rep 5:12030. 2015
    ..Our data support that HSP72 is a suitable biomarker of peri-infarct tissue in the ischemic brain...
  33. doi request reprint Quick adjustment of imaging tracer payload, for in vivo applications of theranostic nanostructures in the brain
    Jesús Agulla
    Department of Neurology, Neurovascular ARea, Clinical Neurosciences Research Laboratory, Hospital Clinico Universitario, Health Research Institute of Santiago de Compostela IDIS, University of Santiago de Compostela, Santiago de Compostela, Spain Research Unit, University Hospital of Salamanca and Institute of Health Sciences of Castilla and Leon, Salamanca, Spain
    Nanomedicine 10:851-8. 2014
    ....
  34. pmc In vivo theranostics at the peri-infarct region in cerebral ischemia
    Jesús Agulla
    1 Department of Neurology, Neurovascular ARea, Clinical Neurosciences Research Laboratory, Hospital Clinico Universitario, Health Research Institute of Santiago de Compostela IDIS, University of Santiago de Compostela, E 15706 Santiago de Compostela, Spain 2 Research Unit, University Hospital of Salamanca and Institute of Health Sciences of Castilla and Leon, E 37007 Salamanca, Spain
    Theranostics 4:90-105. 2013
    ..Our results show the potential of nanotechnology for the development of effective tools for the treatment of neurological diseases. ..
  35. doi request reprint Neuroprotective effect of neuroserpin in rat primary cortical cultures after oxygen and glucose deprivation and tPA
    Raquel Rodríguez-González
    Clinical Neuroscience Research Laboratory, Department of Neurology, Hospital Clinico Universitario, Universidad de Santiago de Compostela, Santiago de Compostela, Spain
    Neurochem Int 58:337-43. 2011
    ..Our results suggest that neuroprotective activity of neuroserpin involves attenuation on tPA-mediated mechanisms of inflammation and BBB disruption after brain ischemia...
  36. doi request reprint Statins and stroke
    Manuel Rodríguez-Yáñez
    Hospital Clinico Universitario, Department of Neurology, Santiago de Compostela, Spain
    Ther Adv Cardiovasc Dis 2:157-66. 2008
    ..They also have other functions that can be related, with better long-term outcome, to neurorepair mechanisms. Statins promote angiogenesis, endogenous cell proliferation, neurogenesis and new synapse formation...
  37. pmc Blood glutamate grabbing does not reduce the hematoma in an intracerebral hemorrhage model but it is a safe excitotoxic treatment modality
    Andrés da Silva-Candal
    Clinical Neurosciences Research Laboratory, Department of Neurology, Hospital Clinico Universitario, Health Research Institute of Santiago de Compostela IDIS, University of Santiago de Compostela, Santiago de Compostela, Spain
    J Cereb Blood Flow Metab 35:1206-12. 2015
    ..More importantly, these findings suggest that blood glutamate grabbers are a safe treatment modality that can be given in cases of suspected ischemic stroke without previous neuroimaging...
  38. ncbi request reprint Platelets, inflammation, and atherothrombotic neurovascular disease: the role of endothelial dysfunction
    Miguel Blanco
    Stroke Unit, Neurology Service, Hospital Clinico Universitario, Santiago de Compostela, Spain
    Cerebrovasc Dis 20:32-9. 2005
    ....
  39. doi request reprint Stroke with polyvascular atherothrombotic disease
    Miguel Blanco
    Department of Neurology, Clinical Neuroscience Research Laboratory, Hospital Clinico Universitario, Universidad de Santiago de Compostela, Travesa da Choupana s n, 15706 Santiago de Compostela, Spain
    Atherosclerosis 208:587-92. 2010
    ..To study the influence of polyvascular atherothrombotic disease on stroke patient prognosis, its relation with inflammatory markers, and to analyze the progression of atherothrombotic disease...
  40. pmc A novel mechanism of neuroprotection: Blood glutamate grabber
    Jose Castillo
    Department of Neurology, Clinical University Hospital, Universidade de Santiago de Compostela, Health Research Institute of Santiago de Compostela, Santiago de Compostela, Spain
    J Cereb Blood Flow Metab 36:292-301. 2016
    ..Future clinical trials will allow to know the real efficacy of this novel therapeutic strategy in stroke patients. ..
  41. doi request reprint Potential protective role of endogenous glutamate-oxaloacetate transaminase against glutamate excitotoxicity in fetal hypoxic-ischaemic asphyxia
    María Pérez-Mato
    Clinical Neurosciences Research Laboratory, Clinical University Hospital, Health Research Institute of Santiago de Compostela IDIS, University of Santiago de Compostela, Santiago de Compostela, A Coruna, Spain
    Dev Med Child Neurol 58:57-62. 2016
    ....
  42. doi request reprint Inflammatory and neuroimmunomodulatory changes in acute cerebral ischemia
    David Brea
    Clinical Neuroscience Research Laboratory, Department of Neurology, Hospital Clinico Universitario de Santiago de Compostela, University of Santiago de Compostela, Santiago de Compostela, Spain
    Cerebrovasc Dis 27:48-64. 2009
    ..In this paper, we review the function of the immune system in cerebral ischemia, particularly inflammation and immunomodulation...
  43. pmc The human Tp53 Arg72Pro polymorphism explains different functional prognosis in stroke
    Jose C Gomez-Sanchez
    Department of Neurology, University Hospital of Salamanca, 37007 Salamanca, Spain
    J Exp Med 208:429-37. 2011
    ..These results suggest that the Tp53 Arg/Arg genotype governs neuronal vulnerability to apoptosis and can be considered as a genetic marker predicting poor functional outcome after stroke...
  44. ncbi request reprint Mmp-9 immunoreactivity in acute migraine
    Rogelio Leira
    Headache and Stroke Unit and Neurovascular Research Laboratory, Department of Neurology, Hospital Clinico Universitario, University of Santiago de Compostela, Spain
    Headache 47:698-702. 2007
    ..To examine the role of matrix metalloproteinase 9 (MMP-9) in migraine during headache and asymptomatic periods...
  45. doi request reprint Targeting the ischemic penumbra
    Pedro Ramos-Cabrer
    Clinical Neurosciences Research Laboratory, Department of Neurology, Hospital Clinico Universitario de Santiago, University of Santiago de Compostela, Santiago de Compostela, Spain
    Stroke 42:S7-11. 2011
    ....
  46. pmc Proteomic analysis of the tear film in patients with keratoconus
    Isabel Lema
    Instituto Galego de Oftalmoloxia, Servizo Galego de Saúde, University of Santiago de Compostela, Santiago de Compostela, Spain
    Mol Vis 16:2055-61. 2010
    ..To identify proteins differentially expressed between the tear film of keratoconus (KC) patients and control subjects using two dimensional electrophoresis (2-DE) and mass spectrometry-based techniques...
  47. doi request reprint Neuroprotective effects of dexmedetomidine conditioning strategies: Evidences from an in vitro model of cerebral ischemia
    Raquel Rodríguez-González
    Department of Nursing, CLINURSID Research group, School of Nursing, University of Santiago de Compostela, Santiago de Compostela, Spain Department of Anesthesiology, Critical Care and Pain Management, Critical Patient Translational Research Group, Hospital Clinico Universitario, Health Research Institute of Santiago de Compostela IDIS, University of Santiago de Compostela, Santiago de Compostela, Spain Electronic address
    Life Sci 144:162-9. 2016
    ..Because perioperative stroke and brain damage are frequent causes of death in critical care units, we aimed to investigate neuroprotective properties of dexmedetomidine using an in vitro model of cerebral ischemia...
  48. doi request reprint Microbleed burden and hematoma expansion in acute intracerebral hemorrhage
    Joan Marti-Fabregas
    Department of Neurology, Hospital de la Santa Creu i Sant Pau IIb Sant Pau, Barcelona, Spain
    Eur Neurol 70:175-8. 2013
    ..Microbleeds (MBs) are surrogate radiological markers that are associated with these underlying angiopathies. We assessed the hypothesis that MBs are associated with hematoma expansion (HE) in patients with hyperacute ICH...
  49. ncbi request reprint Neuroplasticity and cellular therapy in cerebral infarction
    Raquel Rodríguez-González
    Clinical Neuroscience Research Laboratory, Division of Vascular Neurology, Department of Neurology, Hospital Clinico Universitario, University of Santiago de Compostela, Santiago de Compostela, Spain
    Cerebrovasc Dis 24:167-80. 2007
    ..Although steps must still be taken to ensure the safety and feasibility of treatments based on neuroplasticity and cellular therapy, neurorepair strategies provide promising future therapeutic options for stroke...
  50. ncbi request reprint Serum cellular fibronectin and matrix metalloproteinase-9 as screening biomarkers for the prediction of parenchymal hematoma after thrombolytic therapy in acute ischemic stroke: a multicenter confirmatory study
    Mar Castellanos
    Department of Neurology, Hospital Universitari Doctor Josep Trueta, Girona, Spain
    Stroke 38:1855-9. 2007
    ..In this prospective study, we sought to validate the predictive capacity of the preestablished cutoff values of these biomarkers for PH in a larger series of patients...