Julian Romero

Summary

Country: Spain

Publications

  1. doi The endocannabinoid system in neuropathological states
    José Martínez Orgado
    Laboratorio de Apoyo a la Investigacion, Fundacion Hospital Alcorcon CIBERNED, Madrid, Spain
    Int Rev Psychiatry 21:172-80. 2009
  2. ncbi Functional neuroanatomy of the endocannabinoid system
    María Ruth Pazos
    Laboratorio de Apoyo a la Investigacion, Fundacion Hospital Alcorcon, C Budapest 1, Alcorcon, Madrid 28922, Spain
    Pharmacol Biochem Behav 81:239-47. 2005
  3. pmc β-Amyloid exacerbates inflammation in astrocytes lacking fatty acid amide hydrolase through a mechanism involving PPAR-α, PPAR-γ and TRPV1, but not CB₁ or CB₂ receptors
    Cristina Benito
    Laboratorio de Apoyo a la Investigacion, Hospital Universitario Fundacion Alcorcon, Alcorcon, Madrid, Spain
    Br J Pharmacol 166:1474-89. 2012
  4. doi Endocannabinoid regulation of amyloid-induced neuroinflammation
    CARMEN VAZQUEZ
    Laboratorio de Apoyo a la Investigacion, Hospital Universitario Fundacion Alcorcon, Alcorcon, Madrid, Spain
    Neurobiol Aging 36:3008-19. 2015
  5. ncbi The endogenous cannabinoid system and the basal ganglia. biochemical, pharmacological, and therapeutic aspects
    Julian Romero
    Laboratorio de Apoyo a la Investigacion, Fundacion Hospital Alcorcon, Madrid, Spain
    Pharmacol Ther 95:137-52. 2002
  6. ncbi Characterization of the neuroprotective effect of the cannabinoid agonist WIN-55212 in an in vitro model of hypoxic-ischemic brain damage in newborn rats
    David Fernández-López
    Departamento de Farmacologia, Facultad de Medicina, Universidad Complutense, Madrid, Spain
    Pediatr Res 60:169-73. 2006
  7. doi Endocannabinoid-hydrolysing enzymes in the post-mortem cerebellum of humans affected by hereditary autosomal dominant ataxias
    Carmen Rodríguez-Cueto
    Departamento de Bioquimica y Biologia Molecular, Instituto Universitario de Investigación en Neuroquímica, Universidad Complutense, Madrid, Spain
    Pathobiology 81:149-59. 2014
  8. ncbi A glial endogenous cannabinoid system is upregulated in the brains of macaques with simian immunodeficiency virus-induced encephalitis
    Cristina Benito
    Laboratorio de Apoyo a la Investigacion, Fundacion Hospital Alcorcon, 28922 Madrid, Spain
    J Neurosci 25:2530-6. 2005
  9. doi The activation of cannabinoid CB2 receptors stimulates in situ and in vitro beta-amyloid removal by human macrophages
    Rosa María Tolón
    Laboratorio de Apoyo a la Investigacion, Hospital Universitario Fundación Alcorcón and Centro de Investigación Biomédica en Red sobre Enfermedades Neurodegenerativas, 28922 Alcorcon, Madrid, Spain
    Brain Res 1283:148-54. 2009
  10. doi Endocannabinoids regulate the activity of astrocytic hemichannels and the microglial response against an injury: In vivo studies
    CARMEN VAZQUEZ
    Laboratorio de Apoyo a la Investigacion, Hospital Universitario Fundacion Alcorcon, 28922 Alcorcon, Madrid, Spain
    Neurobiol Dis 79:41-50. 2015

Collaborators

  • Javier Fernandez-Ruiz
  • Kenneth Williams
  • Carmen Guaza
  • Isabel Lastres-Becker
  • Manuel Guzman
  • Sara Gonzalez
  • Jose Martinez-Orgado
  • Cristina Benito
  • Rosa María Tolón
  • María Ruth Pazos
  • CARMEN VAZQUEZ
  • Carmen Rodríguez-Cueto
  • Lourdes Ruiz-Valdepeñas
  • Benjamin F Cravatt
  • Estefanía Núñez
  • Rosa M Tolón
  • Cecilia J Hillard
  • Erin C Koester
  • Marta Moreno
  • María Gómez-Ruiz
  • Mariluz Hernández-Gálvez
  • Francisco Javier Fernández-Sánchez
  • Ana Isabel Castillo
  • José Martínez Orgado
  • David Fernández-López
  • Borja Villaescusa
  • M Teresa Grande
  • Marina Caraza
  • Africa Millán
  • Francisca Almodóvar
  • Francisco Arias
  • Mariano Alvarez
  • Conrado Fernández Rodríguez
  • María Teresa Pérez Fernández
  • Jose Luis Lledo
  • Manuel Nevado
  • Juan Jose Gorgojo
  • Ignacio Lizasoain
  • Maria Angeles Moro
  • Pedro Lorenzo
  • Wong Ki Kim
  • Ceceila J Hillard
  • Iván Chavarría
  • Ken Mackie
  • Woong Ki Kim

Detail Information

Publications16

  1. doi The endocannabinoid system in neuropathological states
    José Martínez Orgado
    Laboratorio de Apoyo a la Investigacion, Fundacion Hospital Alcorcon CIBERNED, Madrid, Spain
    Int Rev Psychiatry 21:172-80. 2009
    ....
  2. ncbi Functional neuroanatomy of the endocannabinoid system
    María Ruth Pazos
    Laboratorio de Apoyo a la Investigacion, Fundacion Hospital Alcorcon, C Budapest 1, Alcorcon, Madrid 28922, Spain
    Pharmacol Biochem Behav 81:239-47. 2005
    ....
  3. pmc β-Amyloid exacerbates inflammation in astrocytes lacking fatty acid amide hydrolase through a mechanism involving PPAR-α, PPAR-γ and TRPV1, but not CB₁ or CB₂ receptors
    Cristina Benito
    Laboratorio de Apoyo a la Investigacion, Hospital Universitario Fundacion Alcorcon, Alcorcon, Madrid, Spain
    Br J Pharmacol 166:1474-89. 2012
    ..One experimental approach is the enhancement of endocannabinoid tone by blocking the activity of degradative enzymes, such as fatty acid amide hydrolase (FAAH)...
  4. doi Endocannabinoid regulation of amyloid-induced neuroinflammation
    CARMEN VAZQUEZ
    Laboratorio de Apoyo a la Investigacion, Hospital Universitario Fundacion Alcorcon, Alcorcon, Madrid, Spain
    Neurobiol Aging 36:3008-19. 2015
    ..These data reinforce the notion of a role for the EC system in neuroinflammation and open new perspectives on the relevance of modulating EC levels in the inflamed brain...
  5. ncbi The endogenous cannabinoid system and the basal ganglia. biochemical, pharmacological, and therapeutic aspects
    Julian Romero
    Laboratorio de Apoyo a la Investigacion, Fundacion Hospital Alcorcon, Madrid, Spain
    Pharmacol Ther 95:137-52. 2002
    ..The present article will review the current knowledge of this neuromodulatory system, trying to establish the future lines for research on the therapeutic potential of the endocannabinoid system in motor disorders...
  6. ncbi Characterization of the neuroprotective effect of the cannabinoid agonist WIN-55212 in an in vitro model of hypoxic-ischemic brain damage in newborn rats
    David Fernández-López
    Departamento de Farmacologia, Facultad de Medicina, Universidad Complutense, Madrid, Spain
    Pediatr Res 60:169-73. 2006
    ....
  7. doi Endocannabinoid-hydrolysing enzymes in the post-mortem cerebellum of humans affected by hereditary autosomal dominant ataxias
    Carmen Rodríguez-Cueto
    Departamento de Bioquimica y Biologia Molecular, Instituto Universitario de Investigación en Neuroquímica, Universidad Complutense, Madrid, Spain
    Pathobiology 81:149-59. 2014
    ..We recently found important changes in cannabinoid CB1 and CB2 receptors in the post-mortem cerebellum of patients affected by different SCAs...
  8. ncbi A glial endogenous cannabinoid system is upregulated in the brains of macaques with simian immunodeficiency virus-induced encephalitis
    Cristina Benito
    Laboratorio de Apoyo a la Investigacion, Fundacion Hospital Alcorcon, 28922 Madrid, Spain
    J Neurosci 25:2530-6. 2005
    ....
  9. doi The activation of cannabinoid CB2 receptors stimulates in situ and in vitro beta-amyloid removal by human macrophages
    Rosa María Tolón
    Laboratorio de Apoyo a la Investigacion, Hospital Universitario Fundación Alcorcón and Centro de Investigación Biomédica en Red sobre Enfermedades Neurodegenerativas, 28922 Alcorcon, Madrid, Spain
    Brain Res 1283:148-54. 2009
    ..These data corroborate the possible therapeutic interest of CB(2) cannabinoid specific chemicals in the treatment of Alzheimer's disease...
  10. doi Endocannabinoids regulate the activity of astrocytic hemichannels and the microglial response against an injury: In vivo studies
    CARMEN VAZQUEZ
    Laboratorio de Apoyo a la Investigacion, Hospital Universitario Fundacion Alcorcon, 28922 Alcorcon, Madrid, Spain
    Neurobiol Dis 79:41-50. 2015
    ..In summary, these findings demonstrate that AEA modifies glial functions by promoting an enhanced pro-inflammatory glial response in the brain. ..
  11. pmc Changes in CB(1) and CB(2) receptors in the post-mortem cerebellum of humans affected by spinocerebellar ataxias
    Carmen Rodríguez-Cueto
    Departamento de Bioquimica y Biologia Molecular, Instituto Universitario de Investigación en Neuroquímica, Facultad de Medicina, Universidad Complutense, Madrid, Spain Centro de Investigación Biomédica en Red sobre Enfermedades Neurodegenerativas CIBERNED, Madrid, Spain Instituto Ramón y Cajal de Investigación Sanitaria IRYCIS, Madrid, Spain
    Br J Pharmacol 171:1472-89. 2014
    ..Unlike other motor disorders, the possible role of changes in the endocannabinoid system in the pathogenesis of SCAs has not been investigated...
  12. doi Endocannabinoids and Neurodegenerative Disorders: Parkinson's Disease, Huntington's Chorea, Alzheimer's Disease, and Others
    Javier Fernandez-Ruiz
    Facultad de Medicina, Departamento de Bioquimica y Biologia Molecular III, Instituto Universitario de Investigación en Neuroquímica, Universidad Complutense, Ciudad Universitaria s n, 28040, Madrid, Spain
    Handb Exp Pharmacol 231:233-59. 2015
    ..Such studies will strengthen the possibility that these therapies will be investigated in the clinical scenario and licensed for their use in specific disorders. ..
  13. pmc Prospects for cannabinoid therapies in basal ganglia disorders
    Javier Fernandez-Ruiz
    Departamento de Bioquimica y Biologia Molecular III, Instituto Universitario de Investigación en Neuroquímica, Facultad de Medicina, Universidad Complutense, Madrid, Spain
    Br J Pharmacol 163:1365-78. 2011
    ....
  14. pmc Cannabinoid CB1 receptors are expressed by parietal cells of the human gastric mucosa
    María Ruth Pazos
    Laboratory of Research and Centro de Investigación Biomédica en Red sobre Enfermedades Neurodegenerativas CIBERNED, Fundacion Hospital Alcorcon, Alcorcon, Madrid, Spain
    J Histochem Cytochem 56:511-6. 2008
    ....
  15. ncbi The endocannabinoid system and Alzheimer's disease
    Cristina Benito
    Laboratorio de Apoyo a la Investigacion, Fundacion Hospital Alcorcon, C Budapest 1, 28922 Alcorcon, Madrid, Spain
    Mol Neurobiol 36:75-81. 2007
    ....
  16. pmc Cannabidiol reduces lipopolysaccharide-induced vascular changes and inflammation in the mouse brain: an intravital microscopy study
    Lourdes Ruiz-Valdepeñas
    Laboratorio de Apoyo a la Investigacion, Hospital Universitario Fundación Alcorcón and Centro de Investigación Biomédica en Red sobre Enfermedades Neurodegenerativa, Alcorcon, 28922, Madrid, Spain
    J Neuroinflammation 8:5. 2011
    ..The present study was designed to explore its effects in a mouse model of sepsis-related encephalitis by intravenous administration of lipopolysaccharide (LPS)...