- Repeated ethanol administration modifies the temporal structure of sucrose intake patterns in mice: effects associated with behavioral sensitizationRaul Pastor
Department of Behavioral Neuroscience, Oregon Health and Science University, Portland, OR, USA
Addict Biol 15:324-35. 2010..These data are consistent with current literature suggesting an enhancing effect of drug-induced sensitization on motivational processes involved in reinforcement...
- Involvement of the beta-endorphin neurons of the hypothalamic arcuate nucleus in ethanol-induced place preference conditioning in miceRaul Pastor
Area de Psicobiologia, Universitat Jaume I, Castellon, Spain
Alcohol Clin Exp Res 35:2019-29. 2011....
- Ethanol-stimulated behaviour in mice is modulated by brain catalase activity and H2O2 rate of productionRaul Pastor
Area de Psicobiologia, Universitat Jaume I, Campus de Riv Sec, Apartat 8029 AP, 12071 Castello, Spain
Psychopharmacology (Berl) 165:51-9. 2002..Thus, substrate-level changes could regulate brain catalase activity, thereby modulating the behavioural effects of ethanol...
- Opposite effects of acute versus chronic naltrexone administration on ethanol-induced locomotionCarles Sanchis-Segura
Area de Psicobiologia, Universitat Jaume I, Castelló 12071, Spain
Behav Brain Res 153:61-7. 2004..Therefore, our results are discussed in terms of the proved ability of ethanol to promote the release of beta-endorphins and, consequently, to activate the MOR...
- The role of opioid receptor subtypes in the development of behavioral sensitization to ethanolRaul Pastor
Area de Psicobiologia, Universitat Jaume I, Castello, Spain
Neuropsychopharmacology 31:1489-99. 2006..In addition, these results support previous data suggesting a putative role for the mu opioid receptor endogenous ligand, beta-endorphin, and the hypothalamic arcuate nucleus in ethanol sensitization...
- Naloxone does not attenuate the locomotor effects of ethanol in FAST, SLOW, or two heterogeneous stocks of miceSarah E Holstein
Portland Alcohol Research Center, Oregon Health and Science University, Portland, OR 97239, USA
Psychopharmacology (Berl) 182:277-89. 2005..For example, mice bred for sensitivity (FAST) or insensitivity (SLOW) to the locomotor stimulant effects of ethanol differ in their locomotor response to morphine...
- Brain catalase activity inhibition as well as opioid receptor antagonism increases ethanol-induced HPA axis activationRaul Pastor
Area de Psicobiologia, Universitat Jaume I, Campus de Riu Sec, 12071 Castello, Spain
Alcohol Clin Exp Res 28:1898-906. 2004..The present study assessed whether brain catalase has a role in ethanol-induced activation of the HPA axis, a neuroendocrine system modulated by the endogenous opioid neurotransmission...
- Habituation to test procedure modulates the involvement of dopamine D2- but not D1-receptors in ethanol-induced locomotor stimulation in miceRaul Pastor
Area de Psicobiologia, Universtitat Jaume I Campus de Riu Sec, Avda Sos Baynat s n, 12071 Castello, Spain
Psychopharmacology (Berl) 182:436-46. 2005..However, it is not clear whether novelty modulates ethanol-induced behavioral stimulation and whether DA plays a role in this effect...
- Ethanol drinking-in-the-dark facilitates behavioral sensitization to ethanol in C57BL/6J, BALB/cByJ, but not in mu-opioid receptor deficient CXBK miceErnesto Tarragón
Area de Psicobiologia, Universitat Jaume I, Av Sos Baynat s n, 12071, Castellon, Spain
Pharmacol Biochem Behav 101:14-23. 2012..In terms of its clinical relevance, however, it is important to determine whether this phenomenon can also be produced by voluntary EtOH consumption...
- Role of corticotropin-releasing factor and corticosterone in behavioral sensitization to ethanolRaul Pastor
Department of Behavioral Neuroscience, Oregon Health and Science University, Portland, Oregon, USA
J Pharmacol Exp Ther 341:455-63. 2012..The present results are consistent with current theories proposing a key role for CRF and CRF₁ in drug-induced neuroplasticity, dependence, and addictive behavior...
- Ethanol injected into the hypothalamic arcuate nucleus induces behavioral stimulation in rats: an effect prevented by catalase inhibition and naltrexoneRaul Pastor
Area de Psicobiologia, Universitat Jaume I, Castello, Spain
Behav Pharmacol 19:698-705. 2008....
- Ethanol concentration-dependent effects and the role of stress on ethanol drinking in corticotropin-releasing factor type 1 and double type 1 and 2 receptor knockout miceRaul Pastor
Behavioral Neuroscience Department and Portland Alcohol Research Center, Oregon Health and Science University, Portland, OR, USA
Psychopharmacology (Berl) 218:169-77. 2011..CRF(1) play a role in EtOH-induced behavioral neuroadaptation, in binge-like EtOH consumption, and in heightened EtOH consumption in dependent animals...
- Effect of selective antagonism of mu(1)-, mu(1/2)-, mu(3)-, and delta-opioid receptors on the locomotor-stimulating actions of ethanolRaul Pastor
Area de Psicobiologia, Universtitat Jaume I, Campus de Riu Sec, Castelló 12071, Spain
Drug Alcohol Depend 78:289-95. 2005....
- Intracellular calcium chelation with BAPTA-AM modulates ethanol-induced behavioral effects in micePablo Baliño
Area de Psicobiologia, Universtitat Jaume I, Avda Sos Baynat s n, 12071, Castellon, Spain
Exp Neurol 234:446-53. 2012..Our results are discussed together with data indicating that ethanol appears to be more sensitive to intracellular Ca(2+) manipulations than other psychoactive drugs...
- Participation of L-type calcium channels in ethanol-induced behavioral stimulation and motor incoordination: effects of diltiazem and verapamilPablo Baliño
Area de Psicobiologia, Universtitat Jaume I, Avda Sos Baynat s n, 12071 Castellon, Spain
Behav Brain Res 209:196-204. 2010..In conclusion, these data provide further evidence of the important involvement of L-type calcium channels in the behavioral effects produced by ethanol...
- Corticotropin-releasing factor-1 receptor involvement in behavioral neuroadaptation to ethanol: a urocortin1-independent mechanismRaul Pastor
Departments of Behavioral Neuroscience, Oregon Health and Science University, 3181 SW Sam Jackson Park Road, Portland, OR 97239, USA
Proc Natl Acad Sci U S A 105:9070-5. 2008..A CRF/CRF1-mediated mechanism involving the HPA axis is proposed for acquisition, whereas an extrahypothalamic CRF/CRF1 participation is suggested for expression of sensitization to EtOH...
- The MAO-A inhibitor clorgyline reduces ethanol-induced locomotion and its volitional intake in miceJuan Carlos Ledesma
Area de Psicobiologia, Universitat Jaume I, Avda Sos Baynat s n, 12701 Castellón, Spain
Pharmacol Biochem Behav 116:30-8. 2014..This centrally-formed acetaldehyde within the neurons of the aminergic system could play a role in the neurobehavioral properties of EtOH. ..