Jose Palacios

Summary

Country: Spain

Publications

  1. ncbi Beta- and gamma-catenin expression in endometrial carcinoma. Relationship with clinicopathological features and microsatellite instability
    J Palacios
    Programa de Patologia Molecular, Centro Nacional de Investigaciones Oncológicas Carlos III, Madrid, Spain
    Virchows Arch 438:464-9. 2001
  2. pmc PAI-1 and functional blockade of SNAI1 in breast cancer cell migration
    Elizabeth Fabre-Guillevin
    DYNAMIC Team, IBISC FRE 3190 CNRS Université d Evry Val d Essonne, Genopole, Evry 91000, France
    Breast Cancer Res 10:R100. 2008
  3. pmc The pathology of hereditary breast cancer
    Emiliano Honrado
    Group of Breast and Gynecological Cancer, Centro Nacional de Investigaciones Oncologicas CNIO, Madrid, Spain
    Hered Cancer Clin Pract 2:131-8. 2004
  4. ncbi Immunohistochemical characteristics defined by tissue microarray of hereditary breast cancer not attributable to BRCA1 or BRCA2 mutations: differences from breast carcinomas arising in BRCA1 and BRCA2 mutation carriers
    Jose Palacios
    Laboratory of Breast and Gynecological Cancer, Immunohistological Unit, Centro Nacional de Investigaciones Oncologicas, 28029 Madrid, Spain
    Clin Cancer Res 9:3606-14. 2003
  5. ncbi Phenotypic characterization of BRCA1 and BRCA2 tumors based in a tissue microarray study with 37 immunohistochemical markers
    Jose Palacios
    Breast and Gynaecological Cancer Laboratory, Centro Nacional de Investigaciones Oncologicas CNIO, Madrid, Spain
    Breast Cancer Res Treat 90:5-14. 2005
  6. ncbi Epigenetic and genetic alterations of APC and CDH1 genes in lobular breast cancer: relationships with abnormal E-cadherin and catenin expression and microsatellite instability
    David Sarrio
    Laboratory of Breast and Gynecological Cancer, Molecular Pathology Program, Centro Nacional de Investigaciones Oncologicas, Madrid, Spain
    Int J Cancer 106:208-15. 2003
  7. ncbi Cytoplasmic localization of p120ctn and E-cadherin loss characterize lobular breast carcinoma from preinvasive to metastatic lesions
    David Sarrio
    Molecular Pathology Program, Centro Nacional de Investigaciones Oncologicas CNIO, Madrid, Spain
    Oncogene 23:3272-83. 2004
  8. pmc Vimentin and laminin expression is associated with basal-like phenotype in both sporadic and BRCA1-associated breast carcinomas
    Socorro Maria Rodriguez-Pinilla
    Laboratory of Breast and Gynaecological Cancer, Molecular Pathology Programme, Centro Nacional de Investigaciones Oncologicas CNIO, Madrid, Spain
    J Clin Pathol 60:1006-12. 2007
  9. ncbi Molecular alterations associated with cyclin D1 overexpression in endometrial cancer
    Gema Moreno-Bueno
    Laboratory of Breast and Gynecologic Cancer, Molecular Pathology Program, Centro Nacional de Investigaciones Oncologicas, Madrid, Spain
    Int J Cancer 110:194-200. 2004
  10. ncbi Differential gene expression profile in endometrioid and nonendometrioid endometrial carcinoma: STK15 is frequently overexpressed and amplified in nonendometrioid carcinomas
    Gema Moreno-Bueno
    Laboratory of Breast and Gynaecological Cancer, Molecular Pathology Programme, Centro Nacional de Investigaciones Oncologicas, Madrid, Spain
    Cancer Res 63:5697-702. 2003

Detail Information

Publications54

  1. ncbi Beta- and gamma-catenin expression in endometrial carcinoma. Relationship with clinicopathological features and microsatellite instability
    J Palacios
    Programa de Patologia Molecular, Centro Nacional de Investigaciones Oncológicas Carlos III, Madrid, Spain
    Virchows Arch 438:464-9. 2001
    ..In one, MI would be a key event, while in the other, the APC/beta-catenin/Tcf signaling pathways could be activated. Probably, in some cases, both pathways could simultaneously occur...
  2. pmc PAI-1 and functional blockade of SNAI1 in breast cancer cell migration
    Elizabeth Fabre-Guillevin
    DYNAMIC Team, IBISC FRE 3190 CNRS Université d Evry Val d Essonne, Genopole, Evry 91000, France
    Breast Cancer Res 10:R100. 2008
    ..In this study we aimed to determine if the activity of SNAI1 (a member of the Snail family) is correlated with expression of the PA system components and how this correlation can influence tumoural cell migration...
  3. pmc The pathology of hereditary breast cancer
    Emiliano Honrado
    Group of Breast and Gynecological Cancer, Centro Nacional de Investigaciones Oncologicas CNIO, Madrid, Spain
    Hered Cancer Clin Pract 2:131-8. 2004
    ..The pathological features of hereditary breast cancer can drive specific treatment and influence the process of mutation screening...
  4. ncbi Immunohistochemical characteristics defined by tissue microarray of hereditary breast cancer not attributable to BRCA1 or BRCA2 mutations: differences from breast carcinomas arising in BRCA1 and BRCA2 mutation carriers
    Jose Palacios
    Laboratory of Breast and Gynecological Cancer, Immunohistological Unit, Centro Nacional de Investigaciones Oncologicas, 28029 Madrid, Spain
    Clin Cancer Res 9:3606-14. 2003
    ..Therefore, it is of major importance to define the morphological, immunohistochemical, and molecular features of this group of tumors to improve genetic testing and also gain further insight into the biological characteristics of tumors...
  5. ncbi Phenotypic characterization of BRCA1 and BRCA2 tumors based in a tissue microarray study with 37 immunohistochemical markers
    Jose Palacios
    Breast and Gynaecological Cancer Laboratory, Centro Nacional de Investigaciones Oncologicas CNIO, Madrid, Spain
    Breast Cancer Res Treat 90:5-14. 2005
    ....
  6. ncbi Epigenetic and genetic alterations of APC and CDH1 genes in lobular breast cancer: relationships with abnormal E-cadherin and catenin expression and microsatellite instability
    David Sarrio
    Laboratory of Breast and Gynecological Cancer, Molecular Pathology Program, Centro Nacional de Investigaciones Oncologicas, Madrid, Spain
    Int J Cancer 106:208-15. 2003
    ..The same tumors also show genetic and epigenetic alterations of APC gene. However, altered CDH1 and APC genes do not promote beta-catenin accumulation in this tumor type...
  7. ncbi Cytoplasmic localization of p120ctn and E-cadherin loss characterize lobular breast carcinoma from preinvasive to metastatic lesions
    David Sarrio
    Molecular Pathology Program, Centro Nacional de Investigaciones Oncologicas CNIO, Madrid, Spain
    Oncogene 23:3272-83. 2004
    ..Consequently, p120 may be an important mediator of the oncogenic effects derived from E-CD inactivation, including enhanced motility and invasion, in lobular breast cancer...
  8. pmc Vimentin and laminin expression is associated with basal-like phenotype in both sporadic and BRCA1-associated breast carcinomas
    Socorro Maria Rodriguez-Pinilla
    Laboratory of Breast and Gynaecological Cancer, Molecular Pathology Programme, Centro Nacional de Investigaciones Oncologicas CNIO, Madrid, Spain
    J Clin Pathol 60:1006-12. 2007
    ..To determine whether basal-like phenotype and vimentin and/or laminin are related in both sporadic/familial (BRCA1 or BRCA2 mutated) tumours...
  9. ncbi Molecular alterations associated with cyclin D1 overexpression in endometrial cancer
    Gema Moreno-Bueno
    Laboratory of Breast and Gynecologic Cancer, Molecular Pathology Program, Centro Nacional de Investigaciones Oncologicas, Madrid, Spain
    Int J Cancer 110:194-200. 2004
    ..Cyclin D1 overexpression is associated with gene amplification in NEECs and with nucleocytoplasmic expression of beta-catenin and MSI in EECs...
  10. ncbi Differential gene expression profile in endometrioid and nonendometrioid endometrial carcinoma: STK15 is frequently overexpressed and amplified in nonendometrioid carcinomas
    Gema Moreno-Bueno
    Laboratory of Breast and Gynaecological Cancer, Molecular Pathology Programme, Centro Nacional de Investigaciones Oncologicas, Madrid, Spain
    Cancer Res 63:5697-702. 2003
    ....
  11. ncbi Expression of cadherins and catenins correlates with distinct histologic types of ovarian carcinomas
    David Sarrio
    Molecular Pathology Program, Centro Nacional de Investigaciones Oncologicas CNIO, 28029 Madrid, Spain
    Hum Pathol 37:1042-9. 2006
    ..Oncogenic Wnt signaling plays a role only in endometrioid tumors, where beta-catenin mutations seem to be the main cause of its aberrant expression...
  12. ncbi Abnormalities of E- and P-cadherin and catenin (beta-, gamma-catenin, and p120ctn) expression in endometrial cancer and endometrial atypical hyperplasia
    Gema Moreno-Bueno
    Laboratory of Breast and Gynaecological Cancer, Molecular Pathology Programme, Centro Nacional de Investigaciones Oncologicas CNIO, Madrid, Spain
    J Pathol 199:471-8. 2003
    ..Finally, upregulation of P-cadherin was observed in 28.6% of cases. This alteration was associated with the histology of the lesion, since it was found in 9.5% of AEHs, 27.7% of EECs, and 46.2% of NEECs (p = 0.021)...
  13. ncbi Immunohistochemical classification of non-BRCA1/2 tumors identifies different groups that demonstrate the heterogeneity of BRCAX families
    Emiliano Honrado
    Department of Human Genetics, Spanish National Cancer Centre, Melchor Fernandez Almagro 3, Madrid, Spain
    Mod Pathol 20:1298-306. 2007
    ..In addition we have defined a subset of them that have somatic inactivation of the BRCA1 gene...
  14. ncbi The accumulation of specific amplifications characterizes two different genomic pathways of evolution of familial breast tumors
    Lorenzo Melchor
    Human Genetics Group, Human Cancer Genetics Programme, Spanish National Cancer Center, Madrid, Spain
    Clin Cancer Res 11:8577-84. 2005
    ....
  15. doi The morphological and molecular features of the epithelial-to-mesenchymal transition
    Gema Moreno-Bueno
    Departamento de Bioquimica, Universidad Autonoma de Madrid, Instituto de Investigaciones Biomedicas Alberto Sols CSIC UAM, Madrid, Spain
    Nat Protoc 4:1591-613. 2009
    ..Once the methodology is established, the time required to complete the protocol may vary from 3 to 4 weeks (monolayer cultures) and up to 6-8 weeks if including 3D cultures...
  16. doi Epithelial-mesenchymal transition in breast cancer relates to the basal-like phenotype
    David Sarrio
    Breast and Gynecological Cancer Group, Molecular Pathology Programme, Centro Nacional de Investigaciones Oncologicas, Madrid, Spain
    Cancer Res 68:989-97. 2008
    ....
  17. ncbi Sporadic invasive breast carcinomas with medullary features display a basal-like phenotype: an immunohistochemical and gene amplification study
    Socorro Maria Rodriguez-Pinilla
    Breast and Gynecological Cancer Group, Molecular Pathology Programme, Centro Nacional de Investigaciones Oncologicas, Madrid, Spain
    Am J Surg Pathol 31:501-8. 2007
    ....
  18. ncbi Abnormal ezrin localization is associated with clinicopathological features in invasive breast carcinomas
    David Sarrio
    Breast and Gynaecological Cancer Group, Molecular Pathology Programme, Centro Nacional de Investigaciones Oncologicas CNIO, Madrid, Spain
    Breast Cancer Res Treat 98:71-9. 2006
    ..In conclusion, the switch of ezrin localization from the apical membrane to either the complete membrane or to the cytoplasm is correlated with dedifferentiation and adverse features in invasive breast tumors and cancer cell lines...
  19. ncbi Transcriptional profiling of MCF7 breast cancer cells in response to 5-Fluorouracil: relationship with cell cycle changes and apoptosis, and identification of novel targets of p53
    Hector Hernandez-Vargas
    Breast and Gynaecological Cancer Group, Molecular Pathology Programme, Spanish National Cancer Centre CNIO, Madrid, Spain
    Int J Cancer 119:1164-75. 2006
    ..This molecular characterization of dose- and time-dependent modifications of gene expression after 5-FU treatment should provide a resource for future basic studies addressing the molecular mechanisms of chemotherapy in breast cancer...
  20. ncbi Cyclin D1 gene (CCND1) mutations in endometrial cancer
    Gema Moreno-Bueno
    Laboratory of Breast and Gynaecological Cancer, Molecular Pathology Programme, Centro Nacional de Investigaciones Oncologicas, Melchor Fernandez Almagro 3, 28029 Madrid, Spain
    Oncogene 22:6115-8. 2003
    ..In summary, our data indicate that mutations of CCND1, which probably render the protein insensitive to degradation, represent a previously unreported mechanism of cyclin D1 overexpression in human tumors in vivo...
  21. ncbi Cyclin E gene (CCNE) amplification and hCDC4 mutations in endometrial carcinoma
    Raul Cassia
    Laboratory of Breast and Gynaecological Cancer, Centro Nacional de Investigaciones Oncologicas, Madrid, Spain
    J Pathol 201:589-95. 2003
    ..Although hCDC4 exhibits a low mutation frequency in ECs overexpressing cyclin E, it seems to function as a tumour suppressor gene that is involved in endometrial carcinogenesis...
  22. pmc Functional characterization of E- and P-cadherin in invasive breast cancer cells
    David Sarrio
    Department of Biochemistry UAM, Instituto de Investigaciones Biomedicas Alberto Sols CSIC UAM, Madrid, Spain
    BMC Cancer 9:74. 2009
    ..Alterations in the cadherin-catenin adhesion complexes are involved in tumor initiation, progression and metastasis. However, the functional implication of distinct cadherin types in breast cancer biology is still poorly understood...
  23. ncbi Caveolin-1 expression is associated with a basal-like phenotype in sporadic and hereditary breast cancer
    Socorro María Rodríguez Pinilla
    Breast and Gynaecological Cancer Group, Molecular Pathology Programme, Centro Nacional de Investigaciones Oncologicas, Madrid, Spain
    Breast Cancer Res Treat 99:85-90. 2006
    ..024). In conclusion, this study reports for the first time CAV1 expression in BRCA1 and BRCA2 hereditary breast cancer and identifies CAV1 as a marker associated with a basal-like-phenotype in both hereditary and sporadic breast cancer...
  24. pmc Comprehensive characterization of the DNA amplification at 13q34 in human breast cancer reveals TFDP1 and CUL4A as likely candidate target genes
    Lorenzo Melchor
    Human Genetics Group, Human Cancer Genetics Program, Spanish National Cancer Research Center CNIO, Madrid, E 28029, Spain
    Breast Cancer Res 11:R86. 2009
    ..These genomic aberrations may drive carcinogenesis through the upregulation of proto-oncogenes. We have characterized DNA amplification at the human chromosomal region 13q34 in breast cancer...
  25. ncbi Prognostic significance of basal-like phenotype and fascin expression in node-negative invasive breast carcinomas
    Socorro Maria Rodriguez-Pinilla
    Breast and Gynecological Cancer Group, Molecular Pathology Programme and Department of Human Genetics, Centro Nacional de Investigaciones Oncologicas, Madrid, Spain
    Clin Cancer Res 12:1533-9. 2006
    ..The aim of this study was to determine whether basal-like phenotype and fascin were related in both sporadic and familial tumors and with prognosis in node-negative sporadic breast cancers...
  26. ncbi Sox2: a possible driver of the basal-like phenotype in sporadic breast cancer
    Socorro M Rodriguez-Pinilla
    Laboratory of Breast and Gynaecological Cancer, Molecular Pathology Programme, Centro Nacional de Investigaciones Oncologicas CNIO, Madrid, Spain
    Mod Pathol 20:474-81. 2007
    ..022, 0.005 and <0.001, respectively). Sox2 is preferentially expressed in tumours with basal-like phenotype and may play a role in defining their less differentiated/'stem cell' phenotypic characteristics...
  27. ncbi Frequent E-cadherin gene inactivation by loss of heterozygosity in pleomorphic lobular carcinoma of the breast
    Jose Palacios
    Laboratory of Breast and Gynecological Cancer, Molecular Pathology Program, Centro Nacional de Investigaciones Oncologicas, Madrid, Spain
    Mod Pathol 16:674-8. 2003
    ....
  28. ncbi Inhibition of paclitaxel-induced proteasome activation influences paclitaxel cytotoxicity in breast cancer cells in a sequence-dependent manner
    Hector Hernandez-Vargas
    Breast and Gynaecological Cancer Group, Molecular Pathology Programme, Spanish National Cancer Centre CNIO, Madrid, Spain
    Cell Cycle 6:2662-8. 2007
    ..These findings give support to clinical combinations of taxanes with proteasome inhibitors, outlining the importance of considering the sequence when designing such regimens...
  29. doi Zeb1 and Snail1 engage miR-200f transcriptional and epigenetic regulation during EMT
    Antonio Diaz-Lopez
    Departamento de Bioquimica, Facultad de Medicina, Universidad Autonoma de Madrid UAM, Instituto de Investigaciones Biomedicas Alberto Sols CSIC UAM, IdiPAZ, RETICC, Madrid, Spain
    Int J Cancer 136:E62-73. 2015
    ..The present results thus define a novel functional interplay between Snail and Zeb EMT-TFs in miR-200 family regulation providing a molecular link to their previous involvement in the generation of EMT process in vivo. ..
  30. ncbi Gene expression profiling of breast cancer cells in response to gemcitabine: NF-kappaB pathway activation as a potential mechanism of resistance
    Hector Hernandez-Vargas
    Breast and Gynaecological Cancer Group, Molecular Pathology Programme, Spanish National Cancer Centre, Madrid, Spain
    Breast Cancer Res Treat 102:157-72. 2007
    ..Together with the reported role for NF-kappaB in the induction of resistance to chemotherapy, our data gives support to clinical strategies combining gemcitabine with NF-kappaB inhibitors in breast cancer...
  31. ncbi Expression of the nucleoside-derived drug transporters hCNT1, hENT1 and hENT2 in gynecologic tumors
    Xavier Farre
    Programa de Patologia Molecular, Centro Nacional de Investigaciones Oncologicas, Madrid, Spain
    Int J Cancer 112:959-66. 2004
    ..Since hCNT1, hENT1 and hENT2 recognize fluoropyrimidines as substrates, but with different affinities, this study anticipates high variability in drug uptake efficiency in solid tumors...
  32. ncbi Histopathology of BRCA1- and BRCA2-associated breast cancer
    Emiliano Honrado
    Human Genetics Department, Centro Nacional de Investigaciones Oncologicas CNIO, Madrid, Spain
    Crit Rev Oncol Hematol 59:27-39. 2006
    ..These features could be used to distinguish patients who are likely to carry a BRCA1 or BRCA2 germline mutation, thus indicating which gene should be screened for first in families with a high incidence of breast and ovarian cancer...
  33. ncbi Genetic profiling of epithelial cells expressing E-cadherin repressors reveals a distinct role for Snail, Slug, and E47 factors in epithelial-mesenchymal transition
    Gema Moreno-Bueno
    Breast and Gynecological Cancer Group, Centro Nacional de Investigaciones Oncologicas, Madrid, Spain
    Cancer Res 66:9543-56. 2006
    ..These results indicate that Snail, Slug, and E47 transcription factors induce common and specific genetic programs, supporting a differential role of the factors in tumor progression and invasion...
  34. ncbi The molecular pathology of hereditary breast cancer: genetic testing and therapeutic implications
    Emiliano Honrado
    Human Genetics Department, Centro Nacional de Investigaciones Oncologicas CNIO, Madrid, Spain
    Mod Pathol 18:1305-20. 2005
    ....
  35. doi Nuclear TAZ expression associates with the triple-negative phenotype in breast cancer
    Juan Díaz-Martín
    Department of Pathology Instituto de Biomedicina de Sevilla IBiS, Hospital Universitario Virgen del Rocío CSIC Universidad de Sevilla, Avenida Manuel Siurot s n, 41013 Seville, Spain Red Temática de Investigación Cooperativa en Cáncer RETICC RD012 0036 0017, Madrid, Spain Department of Pathology Hospital Universitario Ramón y Cajal and Instituto Ramón y Cajal de Investigación Sanitaria IRYCIS, Carretera de Colmenar Viejo Km 9 100, 28034 Madrid, Spain Department of Pathology Instituto de Biomedicina de Sevilla IBiS, Hospital Universitario Virgen del Rocío CSIC Universidad de Sevilla, Avenida Manuel Siurot s n, 41013 Seville, Spain Red Temática de Investigación Cooperativa en Cáncer RETICC RD012 0036 0017, Madrid, Spain Department of Pathology Hospital Universitario Ramón y Cajal and Instituto Ramón y Cajal de Investigación Sanitaria IRYCIS, Carretera de Colmenar Viejo Km 9 100, 28034 Madrid, Spain
    Endocr Relat Cancer 22:443-54. 2015
    ..Finally, patients with strong TAZ expression showed poorer clinical outcomes with respect to both recurrence and overall survival. ..
  36. ncbi Telling cells how to die: docetaxel therapy in cancer cell lines
    Hector Hernandez-Vargas
    Spanish National Cancer Centre CNIO, Madrid, Spain
    Cell Cycle 6:780-3. 2007
    ..Recently, we described two different forms of mitotic exit in breast cancer cell lines exposed to docetaxel. The causes and consequences of the dual mechanism of cytotoxicity of this agent are discussed here...
  37. pmc Genomic and mutational profiling of ductal carcinomas in situ and matched adjacent invasive breast cancers reveals intra-tumour genetic heterogeneity and clonal selection
    Lucia Hernandez
    Molecular Pathology Team, Breakthrough Breast Cancer Research Centre, Institute of Cancer Research, London, UK
    J Pathol 227:42-52. 2012
    ....
  38. ncbi "New" molecular taxonomy in breast cancer
    Marta Hergueta-Redondo
    Department of Biochemistry UAM, Instituto de Investigaciones Biomedicas Alberto Sols CSIC UAM, Madrid, Spain
    Clin Transl Oncol 10:777-85. 2008
    ..Although this "new" classification has limitations, it could be useful in the clinical practice, allowing not only a more accurate prognosis in breast cancer patients but also a selective treatment for each predefined subtype...
  39. pmc Angiogenesis-related gene expression profile with independent prognostic value in advanced ovarian carcinoma
    Marta Mendiola
    Department of Pathology, Hospital Universitario La Paz, Universidad Autonoma de Madrid, Madrid, Spain
    PLoS ONE 3:e4051. 2008
    ..This study was planned to identify an angiogenesis-related gene expression profile with prognostic value in advanced ovarian carcinoma patients...
  40. ncbi A high-throughput study in melanoma identifies epithelial-mesenchymal transition as a major determinant of metastasis
    Soledad R Alonso
    Molecular Pathology Programme and Histology and Immunohistochemistry Unit, Centro Nacional de Investigaciones Oncologicas, Hospital Universitario 12 de Octubre, Madrid, Spain
    Cancer Res 67:3450-60. 2007
    ..These data give a better understanding of the biology of this aggressive tumor and may provide new prognostic and patient stratification markers in addition to potential therapeutic targets...
  41. pmc Lysyl oxidase-like 2 (LOXL2), a new regulator of cell polarity required for metastatic dissemination of basal-like breast carcinomas
    Gema Moreno-Bueno
    Departamento de Bioquimica, UAM, Instituto de Investigaciones Biomedicas Alberto Sols, CSIC UAM, IdiPAZ, Instituto de Investigación Sanitaria La Paz, Madrid, Spain
    EMBO Mol Med 3:528-44. 2011
    ..Therefore, intracellular LOXL2 is a new candidate marker of basal-like carcinomas and a target to block metastatic dissemination of this aggressive breast tumour subtype...
  42. pmc Cannabinoids reduce ErbB2-driven breast cancer progression through Akt inhibition
    María M Caffarel
    Dept, Biochemistry and Molecular Biology I, School of Biology, Complutense University, Madrid, Spain
    Mol Cancer 9:196. 2010
    ..We also analyzed the expression of cannabinoid targets in a series of 87 human breast tumors...
  43. ncbi Role of c-Src in human MCF7 breast cancer cell tumorigenesis
    Lorena Gonzalez
    Instituto de Investigaciones Biomedicas Alberto Sols CSIC UAM, Madrid, Spain
    J Biol Chem 281:20851-64. 2006
    ..In both situations, inhibition of tumorigenesis was associated with decreased Ki67 staining and increased apoptosis in tumors. These data undoubtedly demonstrate the relevance of the Src/Fak complex in breast cancer tumorigenesis...
  44. doi Molecular genetic heterogeneity in undifferentiated endometrial carcinomas
    Juan M Rosa-Rosa
    Servicio de Anatomia Patologica, Hospital Universitario Ramon y Cajal, IRYCIS, Universidad de Alcala, Madrid, Spain
    Mod Pathol 29:1390-1398. 2016
    ..These results indicate that undifferentiated and dedifferentiated endometrial carcinomas are molecularly heterogeneous tumors, which may have prognostic value...
  45. pmc The NER-related gene GTF2H5 predicts survival in high-grade serous ovarian cancer patients
    Javier Gayarre
    Human Genetics Group, Spanish National Cancer Research Center CNIO, Madrid, Spain
    J Gynecol Oncol 27:e7. 2016
    ..2-26 deletion previously reported by our group to predict longer survival of high-grade serous ovarian cancer patients...
  46. ncbi Thymidylate synthase expression pattern is a prognostic factor in patients of colorectal cancer treated with 5-fluorouracil
    María Encarnación Fernández-Contreras
    Department of Pathology, Hospital Universitario de la Princesa, Universidad Autonoma, Madrid, Spain
    Int J Oncol 25:877-85. 2004
    ....
  47. ncbi Abnormalities of the APC/beta-catenin pathway in endometrial cancer
    Gema Moreno-Bueno
    Laboratory of Breast and Gynaecological Cancer, Molecular Pathology Programme, Centro Nacional de Investigaciones Oncologicas CNIO, Melchor Fernandez Almagro 3, 28029 Madrid, Spain
    Oncogene 21:7981-90. 2002
    ..Our results demonstrated a high prevalence of alterations in molecules of the APC/beta-catenin pathway, but only mutations in beta-catenin gene are associated with aberrant nuclear localization of beta-catenin...
  48. pmc Gasdermin B expression predicts poor clinical outcome in HER2-positive breast cancer
    Marta Hergueta-Redondo
    Biochemistry Department, Universidad Autonoma de Madrid UAM, Instituto de Investigaciones Biomedicas Alberto Sols CSIC UAM, IdiPAZ, Madrid, Spain
    Oncotarget . 2016
    ..In summary, our data identifies the ERBB2 co-amplified and co-expressed gene GSDMB as a critical determinant of poor prognosis and therapeutic response in HER2-positive breast cancer...
  49. doi Deletion at 6q24.2-26 predicts longer survival of high-grade serous epithelial ovarian cancer patients
    Marta M Kamieniak
    Human Genetics Group, Spanish National Cancer Research Center CNIO, C Melchor Fernandez Almagro 3, 28029, Madrid, Spain
    Mol Oncol 9:422-36. 2015
    ....
  50. doi VGLL1 expression is associated with a triple-negative basal-like phenotype in breast cancer
    Maria Angeles Castilla
    Instituto de Biomedicina de Sevilla CSIC Universidad de SevillaHospital Universitario Virgen del Rocío, Department of Pathology, Avda Manuel Siurot s n, 41013 Seville, SpainRed Temática de Investigación Cooperativa en Cáncer RTICC ISCIII, Madrid, SpainServicio de Anatomía PatológicaHospital Universitario Ramón y Cajal and Instituto Ramón y Cajal de Investigación Sanitaria IRYCIS, Madrid, SpainHuman Genetics GroupDepartamento de Biología del Cáncer, Spanish National Cancer Research Centre CNIO CIBERER, Madrid, SpainDepartment of Technology and HealthIstituto Superiore di Sanità, Rome, ItalyInstituto de Biomedicina de Sevilla CSIC Universidad de SevillaHospital Universitario Virgen del Rocío, Department of Pathology, Avda Manuel Siurot s n, 41013 Seville, SpainRed Temática de Investigación Cooperativa en Cáncer RTICC ISCIII, Madrid, SpainServicio de Anatomía PatológicaHospital Universitario Ramón y Cajal and Instituto Ramón y Cajal de Investigación Sanitaria IRYCIS, Madrid, SpainHuman Genetics GroupDepartamento de Biología del Cáncer, Spanish National Cancer Research Centre CNIO CIBERER, Madrid, SpainDepartment of Technology and HealthIstituto Superiore di Sanità, Rome, Italy
    Endocr Relat Cancer 21:587-99. 2014
    ....
  51. doi Mixed and Ambiguous Endometrial Carcinomas: A Heterogenous Group of Tumors With Different Clinicopathologic and Molecular Genetic Features
    Inigo Espinosa
    Department of Pathology, Hospital de la Santa Creu i Sant Pau, Institute of Biomedical Research IIB Sant Pau, Autonomous University of Barcelona, Barcelona Department of Pathology, Hospital Universitario Ramon y Cajal, Madrid, Spain
    Am J Surg Pathol 40:972-81. 2016
    ..Our series include 2 true mixed endometrial carcinomas with a "low-grade serous"-like component, microcystic, elongated, or fragmented features, KRAS mutations, and aggressive behavior. ..
  52. doi DICER1, DROSHA and miRNAs in patients with non-small cell lung cancer: implications for outcomes and histologic classification
    C Vanesa Díaz-García
    Oncology Department, Hospital Universitario 12 de Octubre, Madrid, 28041, Spain
    Carcinogenesis 34:1031-8. 2013
    ..In addition, differential expression of miRNAs, such as hsa-let-7a and miR-16 may be helpful tools in the histologic subclassification of NSCLC...
  53. ncbi Molecular staging of prostatic cancer with RT-PCR assay for prostate-specific antigen in peripheral blood and lymph nodes: comparison with standard histological staging and immunohistochemical assessment of occult regional lymph node metastases
    Luis Martinez-Pineiro
    Servicio de Urologia, Hospital Universitario La Paz, Paseo de la Castellana 261, 28046, Madrid, Spain
    Eur Urol 43:342-50. 2003
    ..About 30-40% of men with localized prostate cancer undergoing radical prostatectomy will have cancer recurrence. It is estimated that one third recur locally and two thirds develop distant metastases with or without local recurrence...
  54. ncbi Consensus of the Spanish Society of Medical Oncology (SEOM) and Spanish Society of Pathology (SEAP) for HER2 testing in gastric carcinoma
    Carlos Gómez-Martín
    GI Cancer Research Unit, Clinical Research Programme, National Cancer Research Centre, C Melchor Fernandez Almagro 3, Madrid, Spain
    Clin Transl Oncol 13:636-51. 2011
    ..Any laboratories which do not meet the minimum standards set out in the guidelines must make every effort to achieve compliance...