Matilde Murga

Summary

Country: Spain

Publications

  1. pmc POLD3 Is Haploinsufficient for DNA Replication in Mice
    Matilde Murga
    Genomic Instability Group, Spanish National Cancer Research Centre, Madrid 28029, Spain Electronic address
    Mol Cell 63:877-83. 2016
  2. pmc A mouse model of ATR-Seckel shows embryonic replicative stress and accelerated aging
    Matilde Murga
    Genomic Instability Group, Spanish National Cancer Research Centre CNIO, Madrid, Spain
    Nat Genet 41:891-8. 2009
  3. ncbi request reprint Genomic instability: on the birth and death of cancer
    M Murga
    Genomic Instability Group, Molecular Oncology Programme, Spanish National Cancer Center CNIO, Madrid, Spain
    Clin Transl Oncol 9:216-20. 2007
  4. pmc Exploiting oncogene-induced replicative stress for the selective killing of Myc-driven tumors
    Matilde Murga
    Genomic Instability Group, Spanish National Cancer Research Centre, Madrid, Spain
    Nat Struct Mol Biol 18:1331-5. 2011
  5. pmc ATR signaling can drive cells into senescence in the absence of DNA breaks
    Luis I Toledo
    Genomic Instability Group, Spanish National Cancer Research Center CNIO, Madrid 28029, Spain
    Genes Dev 22:297-302. 2008
  6. pmc Limited role of murine ATM in oncogene-induced senescence and p53-dependent tumor suppression
    Alejo Efeyan
    Tumor Suppression Group, Spanish National Cancer Research Centre CNIO, Madrid, Spain
    PLoS ONE 4:e5475. 2009
  7. pmc ATR suppresses telomere fragility and recombination but is dispensable for elongation of short telomeres by telomerase
    Carolyn J McNees
    Telomeres and Telomerase Group, Spanish National Cancer Centre, Madrid 28029, Spain
    J Cell Biol 188:639-52. 2010
  8. pmc USP7 is a SUMO deubiquitinase essential for DNA replication
    Emilio Lecona
    Genomic Instability Group, Spanish National Cancer Research Centre CNIO, Madrid, Spain
    Nat Struct Mol Biol 23:270-7. 2016
  9. pmc NSMCE2 suppresses cancer and aging in mice independently of its SUMO ligase activity
    Ariana Jacome
    Genomic Instability Group, Spanish National Cancer Research Centre, Madrid, Spain
    EMBO J 34:2604-19. 2015
  10. pmc A p53-mediated DNA damage response limits reprogramming to ensure iPS cell genomic integrity
    Rosa M Marion
    Telomeres and Telomerase Group, Molecular Oncology Program, Spanish National Cancer Research Centre CNIO, Melchor Fernandez Almagro 3, Madrid E 28029, Spain
    Nature 460:1149-53. 2009

Collaborators

Detail Information

Publications21

  1. pmc POLD3 Is Haploinsufficient for DNA Replication in Mice
    Matilde Murga
    Genomic Instability Group, Spanish National Cancer Research Centre, Madrid 28029, Spain Electronic address
    Mol Cell 63:877-83. 2016
    ..Finally, we show that Pold3 deletion destabilizes all members of the Polδ complex, explaining its major role in DNA replication and the severe impact of its deficiency. ..
  2. pmc A mouse model of ATR-Seckel shows embryonic replicative stress and accelerated aging
    Matilde Murga
    Genomic Instability Group, Spanish National Cancer Research Centre CNIO, Madrid, Spain
    Nat Genet 41:891-8. 2009
    ....
  3. ncbi request reprint Genomic instability: on the birth and death of cancer
    M Murga
    Genomic Instability Group, Molecular Oncology Programme, Spanish National Cancer Center CNIO, Madrid, Spain
    Clin Transl Oncol 9:216-20. 2007
    ..The review will end up presenting suggestive evidence which proposes that genomic instability might turn out to be not just the driving force but also the Achilles' heel of cancer...
  4. pmc Exploiting oncogene-induced replicative stress for the selective killing of Myc-driven tumors
    Matilde Murga
    Genomic Instability Group, Spanish National Cancer Research Centre, Madrid, Spain
    Nat Struct Mol Biol 18:1331-5. 2011
    ..Besides its impact on cancer, Myc overexpression aggravated the phenotypes of Atr-Seckel mice, revealing that oncogenes can modulate the severity of replicative stress-associated diseases...
  5. pmc ATR signaling can drive cells into senescence in the absence of DNA breaks
    Luis I Toledo
    Genomic Instability Group, Spanish National Cancer Research Center CNIO, Madrid 28029, Spain
    Genes Dev 22:297-302. 2008
    ..Our system provides a novel platform for the study of the specific functions of ATR signaling and adds evidence for the tumor-suppressive potential of the DNA damage response...
  6. pmc Limited role of murine ATM in oncogene-induced senescence and p53-dependent tumor suppression
    Alejo Efeyan
    Tumor Suppression Group, Spanish National Cancer Research Centre CNIO, Madrid, Spain
    PLoS ONE 4:e5475. 2009
    ..Regarding murine Atm, our data suggest that it plays a minor role in oncogene-induced senescence or in p53-dependent tumor suppression, being its tumor suppressive activity probably limited to the maintenance of genomic stability...
  7. pmc ATR suppresses telomere fragility and recombination but is dispensable for elongation of short telomeres by telomerase
    Carolyn J McNees
    Telomeres and Telomerase Group, Spanish National Cancer Centre, Madrid 28029, Spain
    J Cell Biol 188:639-52. 2010
    ..These results reveal a previously unnoticed role for mammalian ATR in telomere protection and stability...
  8. pmc USP7 is a SUMO deubiquitinase essential for DNA replication
    Emilio Lecona
    Genomic Instability Group, Spanish National Cancer Research Centre CNIO, Madrid, Spain
    Nat Struct Mol Biol 23:270-7. 2016
    ....
  9. pmc NSMCE2 suppresses cancer and aging in mice independently of its SUMO ligase activity
    Ariana Jacome
    Genomic Instability Group, Spanish National Cancer Research Centre, Madrid, Spain
    EMBO J 34:2604-19. 2015
    ..Our work reveals that SUMO- and BLM-independent activities of NSMCE2 limit recombination and facilitate segregation; functions of the SMC5/6 complex that are necessary to prevent cancer and aging in mice. ..
  10. pmc A p53-mediated DNA damage response limits reprogramming to ensure iPS cell genomic integrity
    Rosa M Marion
    Telomeres and Telomerase Group, Molecular Oncology Program, Spanish National Cancer Research Centre CNIO, Melchor Fernandez Almagro 3, Madrid E 28029, Spain
    Nature 460:1149-53. 2009
    ....
  11. pmc A cell-based screen identifies ATR inhibitors with synthetic lethal properties for cancer-associated mutations
    Luis I Toledo
    Genomic Instability Group, Spanish National Cancer Research Centre, Madrid, Spain
    Nat Struct Mol Biol 18:721-7. 2011
    ....
  12. pmc ATM regulates ATR chromatin loading in response to DNA double-strand breaks
    Myriam Cuadrado
    Genomic Instability Group, Spanish National Cancer Center, Madrid 28029, Spain
    J Exp Med 203:297-303. 2006
    ..These data provide experimental evidence of an active cross talk between ATM and ATR signaling pathways in response to DNA damage...
  13. pmc Targeting ATR and Chk1 kinases for cancer treatment: a new model for new (and old) drugs
    Luis I Toledo
    Genomic Instability Group, Spanish National Cancer Research Centre CNIO, Madrid, Spain
    Mol Oncol 5:368-73. 2011
    ..In addition, this rationale also implies that the same effect should also be observed for other molecules that target the RS-response (RSR), such as inhibitors of the Chk1-activating kinase ATR...
  14. pmc Global chromatin compaction limits the strength of the DNA damage response
    Matilde Murga
    Genomic Instability Group, Molecular Oncology Programme, Spanish National Cancer Center, Madrid 28029, Spain
    J Cell Biol 178:1101-8. 2007
    ..We propose that slight differences in the epigenetic configuration might account for the cell-to-cell variation in the strength of the DDR observed when groups of cells are challenged with DNA breaks...
  15. doi request reprint Efficacy of ATR inhibitors as single agents in Ewing sarcoma
    Maria Nieto-Soler
    Genomic Instability Group, Spanish National Cancer Research Centre CNIO, Madrid, Spain
    Oncotarget . 2016
    ..Our data shed light onto the sensitivity of ES to genotoxic agents, and identify ATR inhibitors as a potential therapy for Ewing sarcomas...
  16. pmc INK4a/ARF limits the expansion of cells suffering from replication stress
    Angela Monasor
    Genomic Instability Group, Spanish National Cancer Research Centre CNIO, Madrid, Spain
    Cell Cycle 12:1948-54. 2013
    ..Our data reveal an unknown role for INK4a/ARF in limiting the expansion of cells suffering from persistent replication stress, linking this well-known tumor suppressor to the maintenance of genomic integrity. ..
  17. pmc A proteomic characterization of factors enriched at nascent DNA molecules
    Andrés J López-Contreras
    Genomic Instability Group, Spanish National Cancer Research Centre, Madrid 28029, Spain
    Cell Rep 3:1105-16. 2013
    ..This resource provides a panoramic view of the proteins that concentrate in the surroundings of the replisome, which should facilitate future investigations on DNA replication and genome maintenance...
  18. pmc A Genome-wide CRISPR Screen Identifies CDC25A as a Determinant of Sensitivity to ATR Inhibitors
    Sergio Ruiz
    Genomic Instability Group, Spanish National Cancer Research Centre CNIO, Madrid 28029, Spain Electronic address
    Mol Cell 62:307-13. 2016
    ..With ATR inhibitors now entering the clinic, our work provides a better understanding of the mechanisms by which these compounds kill cells and reveals genetic interactions that could be used for their rational use. ..
  19. pmc Increased Rrm2 gene dosage reduces fragile site breakage and prolongs survival of ATR mutant mice
    Andrés J López-Contreras
    Genomic Instability Group, Spanish National Cancer Research Centre CNIO, Madrid 28029, Spain
    Genes Dev 29:690-5. 2015
    ..Our study reveals the first genetic condition in mammals that reduces fragile site expression and alleviates the severity of a progeroid disease by increasing RNR activity...
  20. ncbi request reprint Why cells respond differently to DNA damage: a chromatin perspective
    Oscar Fernandez-Capetillo
    Genomic Instability Group, Molecular Oncology Programme, Spanish National Cancer Research Centre, Madrid, Spain
    Cell Cycle 7:980-3. 2008
    ..We here provide an overview of the available data, including our own, that would be supportive of such a model and discuss how this perspective might be used to explain previous observations...
  21. pmc Targeting the kinase activities of ATR and ATM exhibits antitumoral activity in mouse models of MLL-rearranged AML
    Isabel Morgado-Palacin
    Genomic Instability Group, Spanish National Cancer Research Center, Madrid 28029, Spain
    Sci Signal 9:ra91. 2016
    ..Collectively, these data indicated that ATR or ATM inhibition represent potential therapeutic strategies for the treatment of AML, especially MLL-driven leukemias. ..