Ricardo Moreno-Otero

Summary

Country: Spain

Publications

  1. ncbi request reprint Therapeutic modalities in hepatitis C: challenges and development
    R Moreno-Otero
    Hospital Universitario de la Princesa, Universidad Autonoma de Madrid, Madrid, Spain
    J Viral Hepat 12:10-9. 2005
  2. pmc Liver disease and erythropoietic protoporphyria: a concise review
    María José Casanova-González
    Department of Gastroenterology and Hepatology, Hospital Universitario de la Princesa and Centro de Investigación Biomédica en Red de Enfermedades Hepáticas y Digestivas CIBEREHD, Diego de Leon 62, Planta 3, Madrid 28006, Spain
    World J Gastroenterol 16:4526-31. 2010
  3. pmc Angiogenesis: from chronic liver inflammation to hepatocellular carcinoma
    Paloma Sanz-Cameno
    Laboratory of Investigation, Molecular Biology Unit, Hospital Universitario de la Princesa, Universidad Autonoma de Madrid, 28006 Madrid, Spain
    J Oncol 2010:272170. 2010
  4. pmc Hepatoprotective effects of antioxidants in chronic hepatitis C
    Ricardo Moreno Otero
    Digestive Diseases Service and CIBEREHD Instituto de Salud Carlos III, University Hospital La Princesa, Autonomous University of Madrid, ES 28006, Madrid, Spain
    World J Gastroenterol 16:1937-8. 2010
  5. ncbi request reprint Autoimmune hepatitis after long-term methotrexate therapy for rheumatoid arthritis
    Ricardo Moreno-Otero
    Service of Digestive Diseases and Ciberehd Planta 3, Hospital Universitario de la Princesa, Universidad Autonoma de Madrid, Diego de Leon 62, 28006 Madrid, Spain
    Curr Drug Saf 6:197-200. 2011
  6. pmc Is interferon-beta an alternative treatment for chronic hepatitis C?
    Ricardo Moreno-Otero
    Unit of Hepatology, Hospital Universitario de la Princesa, Universidad Autonoma de Madrid, Spain
    World J Gastroenterol 12:2730-6. 2006
  7. doi request reprint Hepatitis C virus envelope components alter localization of hepatocyte tight junction-associated proteins and promote occludin retention in the endoplasmic reticulum
    Ignacio Benedicto
    Molecular Biology Unit, Hospital Universitario de la Princesa, Madrid, Spain
    Hepatology 48:1044-53. 2008
  8. pmc Hepatitis B virus promotes angiopoietin-2 expression in liver tissue: role of HBV x protein
    Paloma Sanz-Cameno
    Hepatology Planta 3, Hospital Universitario de la Princesa, Diego de Leon 62, E 28006, Madrid, Spain
    Am J Pathol 169:1215-22. 2006
  9. ncbi request reprint Enhanced intrahepatic inducible nitric oxide synthase expression and nitrotyrosine accumulation in primary biliary cirrhosis and autoimmune hepatitis
    Paloma Sanz-Cameno
    Liver Unit, Hospital de la Princesa, Autonomous University of Madrid, Diego de Leon 62, E 28006 Madrid, Spain
    J Hepatol 37:723-9. 2002
  10. ncbi request reprint Hepatocyte growth factor activates endothelial proangiogenic mechanisms relevant in chronic hepatitis C-associated neoangiogenesis
    Jesus Medina
    Liver Unit planta 3, Hospital Universitario de la Princesa, Universidad Autonoma de Madrid, Diego de Leon 62, E 28006 Madrid, Spain
    J Hepatol 38:660-7. 2003

Collaborators

Detail Information

Publications77

  1. ncbi request reprint Therapeutic modalities in hepatitis C: challenges and development
    R Moreno-Otero
    Hospital Universitario de la Princesa, Universidad Autonoma de Madrid, Madrid, Spain
    J Viral Hepat 12:10-9. 2005
    ....
  2. pmc Liver disease and erythropoietic protoporphyria: a concise review
    María José Casanova-González
    Department of Gastroenterology and Hepatology, Hospital Universitario de la Princesa and Centro de Investigación Biomédica en Red de Enfermedades Hepáticas y Digestivas CIBEREHD, Diego de Leon 62, Planta 3, Madrid 28006, Spain
    World J Gastroenterol 16:4526-31. 2010
    ..Some authors recommend that bone marrow transplantation should be considered in liver allograft recipients to prevent recurrence of hepatic disease...
  3. pmc Angiogenesis: from chronic liver inflammation to hepatocellular carcinoma
    Paloma Sanz-Cameno
    Laboratory of Investigation, Molecular Biology Unit, Hospital Universitario de la Princesa, Universidad Autonoma de Madrid, 28006 Madrid, Spain
    J Oncol 2010:272170. 2010
    ....
  4. pmc Hepatoprotective effects of antioxidants in chronic hepatitis C
    Ricardo Moreno Otero
    Digestive Diseases Service and CIBEREHD Instituto de Salud Carlos III, University Hospital La Princesa, Autonomous University of Madrid, ES 28006, Madrid, Spain
    World J Gastroenterol 16:1937-8. 2010
    ..We are particularly interested in investigating how the oxidative and nitrosative stress mechanisms are involved in the pathogenesis of different chronic liver diseases...
  5. ncbi request reprint Autoimmune hepatitis after long-term methotrexate therapy for rheumatoid arthritis
    Ricardo Moreno-Otero
    Service of Digestive Diseases and Ciberehd Planta 3, Hospital Universitario de la Princesa, Universidad Autonoma de Madrid, Diego de Leon 62, 28006 Madrid, Spain
    Curr Drug Saf 6:197-200. 2011
    ..A complete remission was achieved in this patient with corticosteroids therapy...
  6. pmc Is interferon-beta an alternative treatment for chronic hepatitis C?
    Ricardo Moreno-Otero
    Unit of Hepatology, Hospital Universitario de la Princesa, Universidad Autonoma de Madrid, Spain
    World J Gastroenterol 12:2730-6. 2006
    ..It might be worth assessing the value of IFNbeta plus ribavirin in randomized studies with a larger cohort of patients, not eligible or not tolerating standard therapy, and for non-responders...
  7. doi request reprint Hepatitis C virus envelope components alter localization of hepatocyte tight junction-associated proteins and promote occludin retention in the endoplasmic reticulum
    Ignacio Benedicto
    Molecular Biology Unit, Hospital Universitario de la Princesa, Madrid, Spain
    Hepatology 48:1044-53. 2008
    ..Additionally, using a cell culture model of HCV infection, we observed the cytoplasmic dot-like accumulation of occludin in infected Huh7 cells...
  8. pmc Hepatitis B virus promotes angiopoietin-2 expression in liver tissue: role of HBV x protein
    Paloma Sanz-Cameno
    Hepatology Planta 3, Hospital Universitario de la Princesa, Diego de Leon 62, E 28006, Madrid, Spain
    Am J Pathol 169:1215-22. 2006
    ..Therefore, HBx could account for the induction of Ang2 observed in CHB, especially the 50-kd form, contributing to pathological angiogenesis and hepatocellular carcinoma progression...
  9. ncbi request reprint Enhanced intrahepatic inducible nitric oxide synthase expression and nitrotyrosine accumulation in primary biliary cirrhosis and autoimmune hepatitis
    Paloma Sanz-Cameno
    Liver Unit, Hospital de la Princesa, Autonomous University of Madrid, Diego de Leon 62, E 28006 Madrid, Spain
    J Hepatol 37:723-9. 2002
    ....
  10. ncbi request reprint Hepatocyte growth factor activates endothelial proangiogenic mechanisms relevant in chronic hepatitis C-associated neoangiogenesis
    Jesus Medina
    Liver Unit planta 3, Hospital Universitario de la Princesa, Universidad Autonoma de Madrid, Diego de Leon 62, E 28006 Madrid, Spain
    J Hepatol 38:660-7. 2003
    ..Angiogenesis occurs in inflamed portal tracts of chronic hepatitis C (CHC) patients...
  11. ncbi request reprint AM3 inhibits LPS-induced iNOS expression in mice
    Pedro Majano
    Unidad de Biologia Molecular, Hospital Universitario de la Princesa, U A M, Madrid, Spain
    Int Immunopharmacol 5:1165-70. 2005
    ..Together, these results suggest that AM3 modulates the nitric oxide response and points to a possible role for AM3 in the control of the inflammatory response...
  12. doi request reprint Soluble angiogenic factors in patients with acute pancreatitis
    Laura Espinosa
    Servicio de Aparato Digestivo, Hospital Universitario La Princesa, Instituto de Investigación Sanitaria Princesa, Madrid, Spain
    J Clin Gastroenterol 45:630-7. 2011
    ..Angiogenic factors are involved in the physiopathology of several inflammatory diseases and they probably play a role in the pathogenesis of acute pancreatitis (AP)...
  13. doi request reprint Preliminary evidence of sustained expression of angiopoietin-2 during monocyte differentiation in chronic hepatitis C
    Yolanda Rodríguez-Muñoz
    Liver Unit, Hospital Universitario de La Princesa and Instituto de Investigación Sanitaria Princesa, Universidad Autónoma de Madrid and Centro de Investigación Biomédica en Red de Enfermedades Hepáticas y Digestivas, Madrid, Spain
    Liver Int 33:864-70. 2013
    ..Monocytes are essential precursors of antigen-presenting cells, such as macrophages and dendritic cells, and contribute to the pathogenesis of chronic inflammatory diseases and cancer...
  14. ncbi request reprint Chronic hepatitis C and Crohn's disease: nosocomial infection treatment with PEG-interferon plus ribavirin
    Xamila Salcedo-Mora
    Digestive Disease Service, Universidad Autonoma de Madrid, Hospital Universitario de la Princesa, Diego de Leon 62, ES 28006 Madrid, Spain
    Digestion 73:210-4. 2006
    ..We conclude that current antiviral therapies with immunomodulatory effects may be helpful and safe for patients with inflammatory bowel disease infected by hepatitis C virus...
  15. ncbi request reprint Liver injury in inflammatory bowel disease: long-term follow-up study of 786 patients
    Javier P Gisbert
    Gastroenterology Unit, Hospital Universitario de la Princesa, Universidad Autonoma, Madrid, Spain
    Inflamm Bowel Dis 13:1106-14. 2007
    ....
  16. pmc Long-term outcome of chronic hepatitis C patients with sustained virological response to peginterferon plus ribavirin
    Maria Trapero-Marugan
    Gastroenterology Hepatology Department, University Hospital La Princesa and Princesa Research Institute, Autonomous University of Madrid and CIBERehd, C Diego de Leon 62, Madrid, Spain
    World J Gastroenterol 17:493-8. 2011
    ..To assess the clinical, biochemical and virological long-term outcome in chronic hepatitis C (CHC) patients with a sustained virological response (SVR) after peginterferon (PEG-IFN) plus ribavirin combination therapy...
  17. ncbi request reprint The potential of angiogenesis soluble markers in chronic hepatitis C
    Xamila Salcedo
    Liver and Molecular Biology Units, Hospital Universitario de la Princesa, Universidad Autonoma de Madrid, Spain
    Hepatology 42:696-701. 2005
    ..In conclusion, this suggests that serum VEGF, Ang-2, and sTie-2 levels could be useful as noninvasive, mechanistically based markers of response to therapy and disease progression in CHC...
  18. doi request reprint Peginterferon plus ribavirin and sustained virological response in HCV-related cirrhosis: outcomes and factors predicting response
    Conrado M Fernández-Rodríguez
    Hospital Universitario Fundacion Alcorcon, Madrid, Spain
    Am J Gastroenterol 105:2164-72; quiz 2173. 2010
    ..Patients with hepatitis C virus (HCV) cirrhosis are difficult to treat and have a high risk of liver decompensation or hepatocellular carcinoma. We sought to identify factors that could predict treatment response...
  19. doi request reprint The hepatitis B virus X protein induces paracrine activation of human hepatic stellate cells
    Samuel Martín-Vílchez
    Gastroenterology and Hepatology Service, Hospital Universitario La Princesa, Universidad Autonoma de Madrid, Madrid, Spain
    Hepatology 47:1872-83. 2008
    ....
  20. doi request reprint Matrigel-embedded 3D culture of Huh-7 cells as a hepatocyte-like polarized system to study hepatitis C virus cycle
    Francisca Molina-Jiménez
    Molecular Biology Unit, Hospital Universitario de la Princesa, Instituto de Investigación Sanitaria Princesa IP, Madrid 28006, Spain
    Virology 425:31-9. 2012
    ..In conclusion, our findings describe a novel use of Matrigel to study the entire HCV cycle in a more relevant context...
  21. doi request reprint Intrahepatic angiopoietin-2 correlates with Chronic Hepatitis C progression and is induced in HCV replicon systems
    Angel Hernández-Bartolomé
    Instituto Investigación Sanitaria Princesa, IIS IP, Liver Unitv, Madrid, Spain
    Liver Int . 2016
    ..Additionally, the differential influence of structural and non-structural genomic regions of HCV on the expression of angiopoietins and the possible signaling involved were studied...
  22. pmc Angiopoietin-2/angiopoietin-1 as non-invasive biomarker of cirrhosis in chronic hepatitis C
    Angel Hernández-Bartolomé
    Ángel Hernández Bartolomé, Rosario López Rodríguez, Leticia González Moreno, Yolanda Real Martínez, Luisa García Buey, Ricardo Moreno Otero, Paloma Sanz Cameno, Liver Unit, Gastroenterology Service, Instituto Investigación Sanitaria Princesa, IIS IP, 28006 Madrid, Spain
    World J Gastroenterol 22:9744-9751. 2016
    ..To evaluate the efficacy of peripheral blood concentrations of angiopoietins (Ang) as cirrhosis biomarkers of chronic hepatitis C (CHC)...
  23. ncbi request reprint Combined antiviral options for the treatment of chronic hepatitis C
    Jesus Medina
    Unidad de Hepatología planta 3, Hospital Universitario de la Princesa, Universidad Autonoma, Diego de Leon 62, E 28006 Madrid, Spain
    Antiviral Res 60:135-43. 2003
    ....
  24. doi request reprint Evaluation of liver fibrosis by transient elastography in methotrexate treated patients
    Almudena Barbero-Villares
    Servicio de Aparato Digestivo y Centro de Investigación Biomédica en Red de Enfermedades Hepáticas y Digestivas CIBEREHD, Hospital Universitario de la Princesa, Universidad Autonoma de Madrid, Madrid, Spain
    Med Clin (Barc) 137:637-9. 2011
    ....
  25. doi request reprint Corticosteroids modulate angiogenic soluble factors in ulcerative colitis patients
    Inés D Pousa
    Department of Gastroenterology, Hospital Universitario de la Princesa, Madrid, Spain
    Dig Dis Sci 56:871-9. 2011
    ....
  26. ncbi request reprint The prevalence of hepatitis C virus infection in patients with non-Hodgkin's lymphoma
    Javier P Gisbert
    Gastroenterology and Hepatology Service, Hospital Universitario de la Princesa, Universidad Autonoma de Madrid, Spain
    Eur J Gastroenterol Hepatol 16:135-8. 2004
    ..The aim of the present study was to assess the prevalence of hepatitis C virus (HCV) infection among patients with non-Hodgkin's lymphoma (NHL), and to compare it with that of a control group of voluntary blood donors...
  27. doi request reprint Expression of pituitary tumor-transforming gene 1 (PTTG1)/securin in hepatitis B virus (HBV)-associated liver diseases: evidence for an HBV X protein-mediated inhibition of PTTG1 ubiquitination and degradation
    Francisca Molina-Jiménez
    Unidad de Biologia Molecular, Hospital Universitario de la Princesa, 28006 Madrid, Spain
    Hepatology 51:777-87. 2010
    ..We propose that HBx promotes an abnormal accumulation of PTTG1, which may provide new insights into the molecular mechanisms of HBV-related pathogenesis of progressive liver disease leading to HCC development...
  28. doi request reprint [Effects of hepatitis B virus X protein on chronic hepatitis B pathophysiology]
    Samuel Martín-Vílchez
    Servicio de Aparato Digestivo, Hospital Universitario La Princesa, Universidad Autonoma de Madrid, Madrid, Espana
    Med Clin (Barc) 140:508-13. 2013
    ..Finally, this review discusses the pathogenic role of HBx in the progression of chronic hepatitis B through its effects on angiogenic, fibrogenic and oncogenic processes...
  29. ncbi request reprint Evidence of angiogenesis in primary biliary cirrhosis: an immunohistochemical descriptive study
    Jesus Medina
    Unidad de Hepatología planta 3, Hospital Universitario de la Princesa, Universidad Autonoma de Madrid, Diego de Leon 62, E 28006 Madrid, Spain
    J Hepatol 42:124-31. 2005
    ..We aimed at evaluating the cellular infiltrate phenotype; the expression of lymphocyte activation, antigen recognition and cell-adhesion molecules; the occurrence of hepatic angiogenesis and the molecules involved...
  30. ncbi request reprint Hepatitis C virus core protein regulates p300/CBP co-activation function. Possible role in the regulation of NF-AT1 transcriptional activity
    Marta Gomez-Gonzalo
    Unidad de Biologia Molecular, Hospital Universitario de la Princesa, 28006 Madrid, Spain
    Virology 328:120-30. 2004
    ....
  31. ncbi request reprint Hepatocellular carcinoma risk in patients with porphyria cutanea tarda
    Javier P Gisbert
    Gastroenterology and Hepatology Service, Hospital Universitario de la Princesa, Universidad Autonoma de Madrid, Spain
    Eur J Gastroenterol Hepatol 16:689-92. 2004
    ..The aim of our study was to evaluate the incidence of HCC in patients with PCT, and to assess the possible co-factors associated with cancer development...
  32. ncbi request reprint Prevalence of hepatitis C virus infection in porphyria cutanea tarda: systematic review and meta-analysis
    Javier P Gisbert
    Servicio de Gastroenterología y Hepatología, Universidad Autonoma de Madrid, Hospital Universitario de la Princesa, Diego de Leon, 62 28006, Madrid, Spain
    J Hepatol 39:620-7. 2003
    ..To conduct a systematic review and meta-analysis on the prevalence of hepatitis C virus (HCV) infection in porphyria cutanea tarda (PCT)...
  33. ncbi request reprint [Transient elastography (Fibroscan), a new non-invasive method to evaluate hepatic fibrosis]
    Jorge Mendoza
    Servicio de Gastroenterología y Hepatología, Hospital Universitario de la Princesa, Universidad Autonoma de Madrid, Madrid, Spain
    Med Clin (Barc) 126:220-2. 2006
  34. ncbi request reprint Role of vascular endothelial growth factor and angiopoietin systems in serum of Crohn's disease patients
    Inés D Pousa
    Department of Hepato Gastroenterology and Ciberehd University Hospital of La Princesa, Universidad Autonoma de Madrid, Spain
    Inflamm Bowel Dis 14:61-7. 2008
    ....
  35. doi request reprint Dysplasia and colorectal cancer in a patient with ulcerative colitis and primary sclerosing cholangitis: a case report and a short review of the literature
    Maria Chaparro
    Department of Gastroenterology, Hospital Universitario de la Princesa, Instituto de Investigación Sanitaria Princesa and Centro de Investigación Biomédica en Red de Enfermedades Hepáticas y Digestivas, Madrid, Spain
    J Crohns Colitis 7:e61-5. 2013
    ..Surveillance for colorectal cancer should be strongly recommended in this group of patients...
  36. doi request reprint The molecular and pathophysiological implications of hepatitis B X antigen in chronic hepatitis B virus infection
    Samuel Martín-Vílchez
    CIBERehd, ISCIII, Madrid, Spain Servicio Digestivo, Hospital Universitario La Princesa and Instituto de Investigación Biomédica La Princesa, Madrid, Spain
    Rev Med Virol 21:315-29. 2011
    ..This review discusses the function of HBx in the life cycle of HBV and its contribution to the pathogenesis of HCC...
  37. pmc The tight junction-associated protein occludin is required for a postbinding step in hepatitis C virus entry and infection
    Ignacio Benedicto
    Hospital Universitario de la Princesa, Madrid, Spain
    J Virol 83:8012-20. 2009
    ..In summary, we propose that occludin plays an essential role in HCV infection and probably affects late entry events. This observation may provide new insights into HCV infection and related pathogenesis...
  38. ncbi request reprint [Hepatic disease in hereditary hemorrhagic telangiectasia (Rendu-Osler-Weber disease)]
    Rosario Gonzalez-Casas
    Servicio de Aparato Digestivo, Hospital Universitario de la Princesa, Universidad Autonoma de Madrid, Madrid, Espana
    Med Clin (Barc) 129:629-31. 2007
  39. ncbi request reprint Prevalence of hepatitis C virus infection in B-cell non-Hodgkin's lymphoma: systematic review and meta-analysis
    Javier P Gisbert
    Gastroenterology and Hepatology Service, La Princesa University Hospital, Madrid, Spain
    Gastroenterology 125:1723-32. 2003
    ....
  40. pmc Spectrum of anemia associated with chronic liver disease
    Rosario Gonzalez-Casas
    Digestive Disease Service and Center for Investigation of Hepatic and Digestive Diseases, University Hospital La Princesa, Autonomous University of Madrid, Madrid 28006, Spain
    World J Gastroenterol 15:4653-8. 2009
    ..In patients with chronic liver disease, anemia may be exacerbated by deficiency of folic acid and/or vitamin B12 that can occur secondary to inadequate dietary intake or malabsorption...
  41. ncbi request reprint Levofloxacin- vs. ranitidine bismuth citrate-containing therapy after H. pylori treatment failure
    Javier P Gisbert
    Department of Gastroenterology, La Princesa University Hospital, Universidad Autonoma, Madrid, Spain
    Helicobacter 12:68-73. 2007
    ..Our aim was to compare two 7-day triple second-line regimens containing ranitidine bismuth citrate or levofloxacin...
  42. doi request reprint [Chronic C hepatitis genotype 4]
    Rosario Gonzalez-Casas
    Servicio de Aparato Digestivo, Hospital Universitario de La Princesa y Centro de Investigación Biomédica en Red de Enfermedades Hepáticas y Digestivas CIBEREHD, Universidad Autonoma de Madrid, Madrid, Espana
    Med Clin (Barc) 137:31-5. 2011
    ..Nitazoxanide has been used in combination with the classic combination therapy, achieving an improvement in the results...
  43. pmc Interplay among cellular polarization, lipoprotein metabolism and hepatitis C virus entry
    Ignacio Benedicto
    Ignacio Benedicto, Francisca Molina Jiménez, Manuel López Cabrera, Pedro L Majano, Molecular Biology Unit, Hospital Universitario de la Princesa, Instituto de Investigación Sanitaria Princesa IP, Madrid 28006, Spain
    World J Gastroenterol 17:2683-90. 2011
    ..Thus, systems that more closely mimic natural infection are urgently required to elucidate the mechanisms of HCV entry, which will in turn help to design antiviral strategies against this part of the infection process...
  44. ncbi request reprint The mitogenic activity of the liver growth factor is mediated by tumor necrosis factor alpha in rat liver
    Juan J Díaz-Gil
    Servicio de Bioquímica Experimental, Clinica Puerta de Hierro, S Martín de Porres 4, Madrid 28035, Spain
    J Hepatol 38:598-604. 2003
    ..The aim of this study was to determine whether tumor necrosis factor alpha (TNF-alpha) stimulation constitutes a step in the mitogenic pathway of LGF...
  45. ncbi request reprint [Potential impact of contrast-enhanced ultrasonography in the study of focal liver lesions]
    Maria Chaparro
    Servicio de Aparato Digestivo, Hospital Universitario de la Princesa, Madrid, Espana
    Med Clin (Barc) 131:73-7. 2008
    ....
  46. ncbi request reprint Approach to the pathogenesis and treatment of nonalcoholic steatohepatitis
    Jesus Medina
    Liver Unit, University Hospital La Princesa, Autonomous University, Madrid, Spain
    Diabetes Care 27:2057-66. 2004
    ..Therapeutic strategies aimed at modulating insulin resistance, normalizing lipoprotein metabolism, and downregulating inflammatory mediators with probiotics have promising potential...
  47. doi request reprint Prospective evaluation of a clinical guideline recommending early patients discharge in bleeding peptic ulcer
    Maria Chaparro
    Gastroenterology Unit, La Princesa University Hospital and Centro de Investigación Biomédica en Red de Enfermedades Hepáticas y Digestivas, Madrid, Spain
    J Gastroenterol Hepatol 25:1525-9. 2010
    ..To validate an early discharge policy in patients admitted with upper gastrointestinal bleeding (UGIB) due to ulcers...
  48. ncbi request reprint Management of chronic viral hepatitis in HIV-infected patients: Spanish Consensus Conference. October 2000
    Javier Garcia-Samaniego
    Hepatology, Hospital Carlos III, Instituto de Salud Carlos III, Madrid, Spain
    HIV Clin Trials 3:99-114. 2002
    ..The role of orthotopic liver transplantation for co-infected individuals with end-stage liver disease was also assessed...
  49. ncbi request reprint Effect of 5-aminosalicylates on renal function in patients with inflammatory bowel disease: 4-year follow-up study
    Javier P Gisbert
    Gastroenterology Unit, Hospital Universitario de la Princesa and Centro de Investigación Biomédica en Red de Enfermedades Hepáticas y Digestivas CIBEREHD, Madrid, Spain
    Gastroenterol Hepatol 31:477-84. 2008
    ..Our aim was to conduct a retrospective study of IBD patients, both with and without 5-ASA treatment, who underwent regular evaluation of renal function over a 4-year period...
  50. ncbi request reprint AM3 inhibits HBV replication through activation of peripheral blood mononuclear cells
    Pedro Majano
    Molecular Biology Unit, Hospital Universitario de la Princesa, Universidad Autonoma de Madrid, Madrid, Spain
    Int Immunopharmacol 4:921-7. 2004
    ..Our data indicate that the employment of AM3 as an adjuvant administered simultaneously with conventional antiviral drugs may potentiate the endogenous response against viral infection...
  51. doi request reprint The association of the angiopoietin/Tie-2 system with the development of metastasis and leukocyte migration in neuroendocrine tumors
    Nicté Figueroa-Vega
    Service of Endocrinology, Hospital Universitario de la Princesa, Universidad Autonoma de Madrid, Madrid, Spain
    Endocr Relat Cancer 17:897-908. 2010
    ....
  52. ncbi request reprint [Interferon in hepatitis B]
    Luisa Garcia Buey
    Servicio de Aparato Digestivo, Unidad de Hepatologia, Hospital Universitario de la Princesa, Universidad Autonoma de Madrid, Espana
    Enferm Infecc Microbiol Clin 26:19-31. 2008
    ..The combination of nucleos(t)ide analogs with PEG-IFNalpha could achieve much higher sustained response rates; however, which treatment constitutes the most suitable therapeutic strategy requires investigation...
  53. ncbi request reprint [Esophagic multichannel intraluminal impedance. Technical bases and clinical applications]
    Maria Chaparro
    Hospital Universitario de la Princesa, Madrid, Espana
    Med Clin (Barc) 129:510-2. 2007
  54. ncbi request reprint Angiogenesis in chronic inflammatory liver disease
    Jesus Medina
    Liver Unit, Hospital de la Princesa, Universidad Autonoma de Madrid, Spain
    Hepatology 39:1185-95. 2004
    ..The future perspectives for research in this field are outlined...
  55. ncbi request reprint Pathophysiological basis for antioxidant therapy in chronic liver disease
    Jesus Medina
    Unidad de Hepatologia, Hospital Universitario de la Princesa, Universidad Autonoma de Madrid, Spain
    Drugs 65:2445-61. 2005
    ..The use of antioxidants (e.g. S-adenosylmethionine [SAMe; ademetionine], tocopherol [vitamin E], polyenylphosphatidylcholine or silymarin) has already shown promising results in some of these pathologies...
  56. ncbi request reprint 13C-urea breath test during hospitalization for the diagnosis of Helicobacter pylori infection in peptic ulcer bleeding
    Javier P Gisbert
    Service of Gastroenterology and Hepatology, La Princesa University Hospital, Universidad Autonoma, Madrid, Spain
    Helicobacter 12:231-7. 2007
    ..To evaluate the accuracy of (13)C-urea breath test (UBT) to detect Helicobacter pylori infection in patients hospitalized with peptic ulcer bleeding and treated with proton pump inhibitors (PPIs)...
  57. ncbi request reprint N-Acetyl-cysteine modulates inducible nitric oxide synthase gene expression in human hepatocytes
    Pedro Lorenzo Majano
    Unidad de Hepatología planta 3, Hospital Universitario de la Princesa, Universidad Autonoma, Diego de Leon 62, E 28006 Madrid, Spain
    J Hepatol 40:632-7. 2004
    ..It attenuates NO generation following lipopolysaccharide injection in rats. Our goal was to study the effect of NAC on NO synthase induction in hepatocytes in response to proinflammatory cytokines...
  58. ncbi request reprint Computed tomography colonography compared with conventional colonoscopy for the detection of colorectal polyps
    María Chaparro Sánchez
    Department of Gastroenterology and Hepatology, University Hospital La Princesa, Madrid, Spain
    Gastroenterol Hepatol 30:375-80. 2007
    ..To determine the diagnostic accuracy of computed tomography colonography (CTC) compared with conventional colonoscopy (CC)...
  59. ncbi request reprint Maintenance of T1 response as induced during PEG-IFNalpha plus ribavirin therapy controls viral replication in genotype-1 patients with chronic hepatitis C
    M Trapero
    Unit of Hepatology, Hospital Universitario de la Princesa, Universidad Autonoma, Madrid, Spain
    Rev Esp Enferm Dig 97:481-90. 2005
    ..To correlate Th1/Th2 balance with virological response...
  60. ncbi request reprint Interferon-alpha plus ribavirin for 12 months increases the sustained response rates in chronic hepatitis C relapsers
    J A Moreno-Monteagudo
    Liver Unit, Hospital de la Princesa, Autonomous University of Madrid, C Diego de Leon 62, 28006 Madrid, Spain
    Aliment Pharmacol Ther 16:243-9. 2002
    ..The effectiveness and tolerability of combination therapy for 12 months have not been evaluated sufficiently in chronic hepatitis C relapsers to interferon...
  61. ncbi request reprint Sustained virological response to peginterferon plus ribavirin in chronic hepatitis C genotype 1 patients is associated with a persistent Th1 immune response
    M Trapero-Marugan
    Gastroenterology and Hepatology Service, Hospital Universitario de la Princesa, Madrid, Spain
    Aliment Pharmacol Ther 24:117-28. 2006
    ..An impairment of cellular immune response may contribute to the persistency of hepatitis C virus infection...
  62. ncbi request reprint [Interaction of the hepatitis C virus with the cellular membrane]
    P Sanz-Cameno
    Unidad de Biologia Molecular, Hospital Universitario de la Princesa, Universidad Autonoma de Madrid, Espana
    Gastroenterol Hepatol 25:521-5. 2002
  63. ncbi request reprint Review article: immunopathogenetic and therapeutic aspects of autoimmune hepatitis
    J Medina
    Liver Unit, Hospital de la Princesa, Autonomous University of Madrid, Diego de Leon 62, E 28006 Madrid, Spain
    Aliment Pharmacol Ther 17:1-16. 2003
    ..Liver transplantation is indicated for patients refractory to or intolerant of immunosuppressive therapy...
  64. ncbi request reprint Clinical and pathological characteristics and response to combination therapy of genotype 4 chronic hepatitis C patients: experience from a spanish center
    M Trapero-Marugan
    Gastroenterology and Hepatology Department, Hospital Universitario de la Princesa, Autonomous University of Madrid, Spain
    J Chemother 19:423-7. 2007
    ..In conclusion, the lower stage of fibrosis, lower viremia and higher SVR rate than genotype 1 suggest a less aggressive pattern of diseased caused by this genotype...
  65. ncbi request reprint Empirical rescue therapy after Helicobacter pylori treatment failure: a 10-year single-centre study of 500 patients
    J P Gisbert
    Gastroenterology Unit, Hospital Universitario de la Princesa and Ciberehd, Universidad Autonoma, Madrid, Spain
    Aliment Pharmacol Ther 27:346-54. 2008
    ..Several 'rescue' therapies have been recommended to eradicate Helicobacter pylori, but they still fail in >20% of the cases, and these patients constitute a therapeutic dilemma...
  66. ncbi request reprint Treatment regimens for patients with chronic hepatitis C
    M Trapero-Marugan
    Digestive Diseases Department and CIBEREHD, Hospital Universitario de la Princesa, C Diego de Leon 62, Madrid, Spain
    Minerva Gastroenterol Dietol 54:209-17. 2008
    ....
  67. pmc AM3, a natural glycoconjugate, induces the functional maturation of human dendritic cells
    S Martín-Vílchez
    Liver Unit, Hospital Universitario de la Princesa, CIBER EHD, Spain
    Br J Pharmacol 154:698-708. 2008
    ..Here, we have investigated the effects of Inmunoferon-active principle (AM3), the active agent of a commercial immunomodulatory drug, on human monocyte-derived DCs (MDDCs)...
  68. ncbi request reprint Third-line rescue therapy with levofloxacin is more effective than rifabutin rescue regimen after two Helicobacter pylori treatment failures
    J P Gisbert
    Department of Gastroenterology, La Princesa University Hospital, Universidad Autonoma, Madrid, Spain
    Aliment Pharmacol Ther 24:1469-74. 2006
    ..In patients with a first eradication failure, a second (rescue) therapy still fails in > 20% of cases...
  69. ncbi request reprint Treatment of chronic he1patitis C genotype 1 with peginterferon-alpha2a (40 kDa) plus ribavirin under routine clinical practice in Spain: early prediction of sustained virological response rate
    M Diago
    Hospital General de Valencia, Valencia, Spain
    Aliment Pharmacol Ther 25:899-906. 2007
    ..Sustained virological response rates of up to 52% have been obtained with peginterferon alpha2a (40 kDa) plus ribavirin in patients suffering from chronic hepatitis C genotype 1 in randomized-controlled trials...
  70. ncbi request reprint Systematic review: regression of lymphoproliferative disorders after treatment for hepatitis C infection
    J P Gisbert
    Gastroenterology and Hepatology Service, La Princesa University Hospital, 28006 Madrid, Spain
    Aliment Pharmacol Ther 21:653-62. 2005
    ....
  71. ncbi request reprint Hepatitis C virus-related extra-hepatic disease--aetiopathogenesis and management
    J Medina
    Unidad de Hepatologia, Hospital de la Princesa, Universidad Autonoma de Madrid, Spain
    Aliment Pharmacol Ther 20:129-41. 2004
    ..In some cases, interferon-alpha may induce or exacerbate some extra-hepatic manifestations...
  72. ncbi request reprint Transient elastography: a valid alternative to biopsy in patients with chronic liver disease
    E Gómez-Domínguez
    Gastroenterology and Hepatology Service, Hospital Universitario de la Princesa, Universidad Autonoma de Madrid, Madrid, Spain
    Aliment Pharmacol Ther 24:513-8. 2006
    ..Transient elastography is a novel and non-invasive technique for the evaluation of fibrosis in chronic liver disease. Few studies that exist value the efficacy of transient elastography, mainly in hepatitis C virus-infected patients...
  73. ncbi request reprint Lamivudine response of IgM anti-HBc chronic hepatitis B patients
    E Gómez-Domínguez
    Aliment Pharmacol Ther 23:1757-8; author reply 1758-60. 2006
  74. pmc Liver fibrosis assessment by transient elastography in hepatitis C patients with normal alanine aminotransferase
    R Moreno-Otero
    Gut 55:1055-6. 2006
  75. ncbi request reprint Association between angiogenesis soluble factors and disease progression markers in chronic hepatitis C patients
    X Salcedo Mora
    Unit of Hepatology, Hospital Universitario de la Princesa, Universidad Autonoma, Madrid, Spain
    Rev Esp Enferm Dig 97:699-706. 2005
    ....