Joan Montaner

Summary

Country: Spain

Publications

  1. doi request reprint Reperfusion therapy for acute stroke improves outcome by decreasing neuroinflammation
    Joan Montaner
    Neurovascular Research Laboratory, Institut de Recerca, Hospital Vall d Hebron, Pg Vall d Hebron 119 129, 08035, Barcelona, Spain
    Transl Stroke Res 1:261-7. 2010
  2. pmc ADAMTS proteoglycanases in the physiological and pathological central nervous system
    Sighild Lemarchant
    Department of Neurobiology, A, I, Virtanen Institute for Molecular Sciences, Biocenter Kuopio, University of Eastern Finland, P, O, Box 1627, 70211 Kuopio, Finland
    J Neuroinflammation 10:133. 2013
  3. pmc Investigating silent strokes in hypertensives: a magnetic resonance imaging study (ISSYS): rationale and protocol design
    Iolanda Riba-Llena
    Neurovascular Research Laboratory, Institut de Recerca Vall Hebron, Universitat Autonoma de Barcelona, Passeig Vall d Hebron 119 129, Barcelona, 08035, Spain
    BMC Neurol 13:130. 2013
  4. pmc Blood biomarkers in cardioembolic stroke
    Teresa García-Berrocoso
    Neurovascular Research Laboratory, Institut de Recerca Vall d Hebron and Neurovascular Unit Neurology Department Universitat Autònoma de Barcelona Medicine Department Hospital Vall d Hebron Barcelona, Spain
    Curr Cardiol Rev 6:194-201. 2010
  5. pmc Update on the Serum Biomarkers and Genetic Factors Associated with Safety and Efficacy of rt-PA Treatment in Acute Stroke Patients
    C Nafría
    Neurovascular Research Laboratory, Neurology and Medicine Departments, Vall d Hebron Research Institute, Universitat Autònoma de Barcelona VHIR UAB, 08035 Barcelona, Spain
    Stroke Res Treat 2011:182783. 2011
  6. doi request reprint Brain natriuretic peptide is associated with worsening and mortality in acute stroke patients but adds no prognostic value to clinical predictors of outcome
    J Montaner
    Neurovascular Research Laboratory, Vall d Hebron University Hospital Research Institute, Universitat Autonoma de Barcelona, Barcelona, Spain
    Cerebrovasc Dis 34:240-5. 2012
  7. doi request reprint Differentiating ischemic from hemorrhagic stroke using plasma biomarkers: the S100B/RAGE pathway
    Joan Montaner
    Neurovascular Research Laboratory, Vall d Hebron University Hospital, Research Institut, Universitat Autonoma de Barcelona, Barcelona, Spain
    J Proteomics 75:4758-65. 2012
  8. doi request reprint MMP-2/MMP-9 plasma level and brain expression in cerebral amyloid angiopathy-associated hemorrhagic stroke
    Mar Hernandez-Guillamon
    Neurovascular Research Laboratory, Institut de Recerca Neurovascular Unit Neurology and Medicine Departments, Universitat Autonoma de Barcelona, Spain
    Brain Pathol 22:133-41. 2012
  9. doi request reprint A panel of biomarkers including caspase-3 and D-dimer may differentiate acute stroke from stroke-mimicking conditions in the emergency department
    J Montaner
    Neurovascular Research Laboratory, Universitat Autonoma de Barcelona, Vall d Hebron Hospital, Barcelona, Spain
    J Intern Med 270:166-74. 2011
  10. doi request reprint Endogenous activated protein C predicts hemorrhagic transformation and mortality after tissue plasminogen activator treatment in stroke patients
    Maite Mendioroz
    Neurovascular Research Laboratory, Neurovascular Unit, Neurology Department, Internal Medicine Department, Vall d Hebron Hospital, Universitat Autonoma de Barcelona, Barcelona, Spain
    Cerebrovasc Dis 28:143-50. 2009

Detail Information

Publications95

  1. doi request reprint Reperfusion therapy for acute stroke improves outcome by decreasing neuroinflammation
    Joan Montaner
    Neurovascular Research Laboratory, Institut de Recerca, Hospital Vall d Hebron, Pg Vall d Hebron 119 129, 08035, Barcelona, Spain
    Transl Stroke Res 1:261-7. 2010
    ..005). tPA treatment reduces the severity of the inflammatory phenomena that follows stroke. These results may partially explain the efficacy of reperfusion therapy on stroke outcome. ..
  2. pmc ADAMTS proteoglycanases in the physiological and pathological central nervous system
    Sighild Lemarchant
    Department of Neurobiology, A, I, Virtanen Institute for Molecular Sciences, Biocenter Kuopio, University of Eastern Finland, P, O, Box 1627, 70211 Kuopio, Finland
    J Neuroinflammation 10:133. 2013
    ..Altogether, this review allows us to propose that ADAMTS proteoglycanases may be original therapeutic targets for CNS injuries. ..
  3. pmc Investigating silent strokes in hypertensives: a magnetic resonance imaging study (ISSYS): rationale and protocol design
    Iolanda Riba-Llena
    Neurovascular Research Laboratory, Institut de Recerca Vall Hebron, Universitat Autonoma de Barcelona, Passeig Vall d Hebron 119 129, Barcelona, 08035, Spain
    BMC Neurol 13:130. 2013
    ....
  4. pmc Blood biomarkers in cardioembolic stroke
    Teresa García-Berrocoso
    Neurovascular Research Laboratory, Institut de Recerca Vall d Hebron and Neurovascular Unit Neurology Department Universitat Autònoma de Barcelona Medicine Department Hospital Vall d Hebron Barcelona, Spain
    Curr Cardiol Rev 6:194-201. 2010
    ....
  5. pmc Update on the Serum Biomarkers and Genetic Factors Associated with Safety and Efficacy of rt-PA Treatment in Acute Stroke Patients
    C Nafría
    Neurovascular Research Laboratory, Neurology and Medicine Departments, Vall d Hebron Research Institute, Universitat Autònoma de Barcelona VHIR UAB, 08035 Barcelona, Spain
    Stroke Res Treat 2011:182783. 2011
    ..We thus reviewed the literature in order to identify biochemical and genetic factors that have been associated with safety and efficacy of rt-PA administration after stroke...
  6. doi request reprint Brain natriuretic peptide is associated with worsening and mortality in acute stroke patients but adds no prognostic value to clinical predictors of outcome
    J Montaner
    Neurovascular Research Laboratory, Vall d Hebron University Hospital Research Institute, Universitat Autonoma de Barcelona, Barcelona, Spain
    Cerebrovasc Dis 34:240-5. 2012
    ..Although the prognostic role of natriuretic peptides has been studied in heart failure and coronary diseases, the value of brain natriuretic peptide (BNP) is less known within the field of strokes...
  7. doi request reprint Differentiating ischemic from hemorrhagic stroke using plasma biomarkers: the S100B/RAGE pathway
    Joan Montaner
    Neurovascular Research Laboratory, Vall d Hebron University Hospital, Research Institut, Universitat Autonoma de Barcelona, Barcelona, Spain
    J Proteomics 75:4758-65. 2012
    ..This article is part of a Special Issue entitled: Translational Proteomics...
  8. doi request reprint MMP-2/MMP-9 plasma level and brain expression in cerebral amyloid angiopathy-associated hemorrhagic stroke
    Mar Hernandez-Guillamon
    Neurovascular Research Laboratory, Institut de Recerca Neurovascular Unit Neurology and Medicine Departments, Universitat Autonoma de Barcelona, Spain
    Brain Pathol 22:133-41. 2012
    ..In summary, MMP-2 expression within and around Aβ-compromised vessels might contribute to the vasculature fatal fate, triggering an eventual bleeding...
  9. doi request reprint A panel of biomarkers including caspase-3 and D-dimer may differentiate acute stroke from stroke-mimicking conditions in the emergency department
    J Montaner
    Neurovascular Research Laboratory, Universitat Autonoma de Barcelona, Vall d Hebron Hospital, Barcelona, Spain
    J Intern Med 270:166-74. 2011
    ..At present, a rapid and widely available diagnostic test for stroke remains elusive. The aim of this study was to examine the predictive value of a panel of blood-borne biochemical markers for stroke diagnosis...
  10. doi request reprint Endogenous activated protein C predicts hemorrhagic transformation and mortality after tissue plasminogen activator treatment in stroke patients
    Maite Mendioroz
    Neurovascular Research Laboratory, Neurovascular Unit, Neurology Department, Internal Medicine Department, Vall d Hebron Hospital, Universitat Autonoma de Barcelona, Barcelona, Spain
    Cerebrovasc Dis 28:143-50. 2009
    ..Therefore, we sought to investigate the role of endogenous APC in human ischemic stroke...
  11. doi request reprint A large screening of angiogenesis biomarkers and their association with neurological outcome after ischemic stroke
    Míriam Navarro-Sobrino
    Neurovascular Research Laboratory and Neurovascular Unit, Neurology and Medicine Department Universitat Autònoma de Barcelona, Research Institute of the Vall d Hebron Hospital, Barcelona, Spain
    Atherosclerosis 216:205-11. 2011
    ..The induction of angiogenesis after stroke may enhance neurorestorative processes. Our aim was to examine the endogenous angiogenesis balance and their association with long-term clinical outcome in ischemic stroke patients...
  12. doi request reprint CD40-1C>T polymorphism (rs1883832) is associated with brain vessel reocclusion after fibrinolysis in ischemic stroke
    Alberto del Rio-Espinola
    Neurovascular Research Laboratory, Institut de Recerca, Hospital Vall d Hebron, Pg Vall d Hebron 119 129, 08035, Barcelona, Spain
    Pharmacogenomics 11:763-72. 2010
    ..To find genetic predictors of reocclusion after successful fibrinolytic therapy during the acute phase of ischemic stroke...
  13. doi request reprint Temporal profile and prognostic value of Lp-PLA2 mass and activity in the acute stroke setting
    Pilar Delgado
    Neurovascular Research Laboratory and Department of Neurology, Universitat Autonoma de Barcelona, Institut de Recerca, Hospital Vall d Hebron, Barcelona, Spain
    Atherosclerosis 220:532-6. 2012
    ..Lp-PLA2 is a novel biomarker in cardiovascular diseases due to its ability to predict first-ever and recurrent stroke. Little information is known regarding its influence on early outcome after stroke...
  14. doi request reprint Progression of symptomatic intracranial large artery atherosclerosis is associated with a proinflammatory state and impaired fibrinolysis
    Juan F Arenillas
    Neurovascular Unit, Vall d Hebron Universitary Hospital, Barcelona, Spain
    Stroke 39:1456-63. 2008
    ..Our objective was to prospectively study the relationship between circulating levels of inflammatory markers and fibrinolysis inhibitors, and the risk of progression of symptomatic ILA...
  15. ncbi request reprint Predictors of early arterial reocclusion after tissue plasminogen activator-induced recanalization in acute ischemic stroke
    Marta Rubiera
    Department of Neurology, Hospital Vall d Hebron, Universitat Autonoma de Barcelona, Spain
    Stroke 36:1452-6. 2005
    ..We aimed to determine clinical and hemodynamic predictors of early reocclusion (RO) in stroke patients treated with intravenous tissue plasminogen activator (tPA)...
  16. doi request reprint Fluorescent molecular peroxidation products: a prognostic biomarker of early neurologic deterioration after thrombolysis
    Victor Llombart
    From Neurovascular Research Laboratory, Institut de Recerca Vall d Hebron, Neurovascular Unit, Department of Neurology, Universitat Autonoma de Barcelona, Barcelona, Spain V L, A B, T G B, A P, M H G, D G, A R, J M Biochemistry and Molecular Biology Research Centre for Nanomedicine, Hospital Universitari Vall d Hebron, Instituto de Salud Carlos III, Centre for Biomedical Research on Rare Diseases, Barcelona, Spain C D, V R S, P M G, A V Neurovascular Unit, Department of Neurology, Vall d Hebron University Hospital, Barcelona, Spain M Rubiera, M Ribó, C A M, J A S Boehringer Ingelheim Pharma GmbH and Co KG, Ingelheim, Germany C E and Department of Neurology, University Hospital of Schleswig Holstein, Kiel, Germany C E
    Stroke 45:432-7. 2014
    ..This study aimed to determine the value of FMPPs as a biomarker to predict neurological worsening related to early hemorrhagic transformation...
  17. ncbi request reprint Admission fibrinolytic profile is associated with symptomatic hemorrhagic transformation in stroke patients treated with tissue plasminogen activator
    Marc Ribo
    Neurovascular Research Laboratory, Neurovascular Unit Hospital Vall d Hebron, Barcelona, Spain
    Stroke 35:2123-7. 2004
    ..We aim to determine the predictive value of pretreatment levels of fibrinolysis inhibitors (PAI-1, lipoprotein(a), TAFI, and homocysteine) on SICH...
  18. doi request reprint Lipoprotein-associated phospholipase A(2) activity is associated with large-artery atherosclerotic etiology and recurrent stroke in TIA patients
    Pilar Delgado
    Neurovascular Research Laboratory and Department of Neurology, Universitat Autonoma de Barcelona
    Cerebrovasc Dis 33:150-8. 2012
    ..We aimed to investigate Lp-PLA(2) levels in transient ischemic attack (TIA) patients and to study their relationship with stroke recurrence...
  19. ncbi request reprint Poststroke C-reactive protein is a powerful prognostic tool among candidates for thrombolysis
    Joan Montaner
    Departament de Medicina Interna, Vall d Hebron Hospital, Universitat Autonoma de Barcelona, Barcelona, Spain
    Stroke 37:1205-10. 2006
    ..We sought to investigate whether CRP measured before tissue plasminogen activator (tPA) treatments may add prognostic information to guide stroke thrombolysis...
  20. ncbi request reprint A matrix metalloproteinase protein array reveals a strong relation between MMP-9 and MMP-13 with diffusion-weighted image lesion increase in human stroke
    Anna Rosell
    Neurology Department, Universitat Autonoma de Barcelona, Hospital Vall d Hebron, Barcelona, Spain
    Stroke 36:1415-20. 2005
    ..In the present study we use an MMP array to investigate the blood levels of several MMPs in stroke patients and its relation with brain tissue damage and neurological outcome...
  21. ncbi request reprint Safety profile of tissue plasminogen activator treatment among stroke patients carrying a common polymorphism (C-1562T) in the promoter region of the matrix metalloproteinase-9 gene
    Joan Montaner
    Neurovascular Research Laboratory, Stroke Unit, Vall d Hebron Hospital, Barcelona, Spain
    Stroke 34:2851-5. 2003
    ....
  22. doi request reprint Etiologic diagnosis of ischemic stroke subtypes with plasma biomarkers
    Joan Montaner
    Neurovascular Research Laboratory, Neurovascular Unit, Neurology Department, Vall d Hebron Hospital, Barcelona, Spain
    Stroke 39:2280-7. 2008
    ..Because there is no biologic marker offering precise information about stroke etiology, many patients receive a diagnosis of undetermined stroke even after all available diagnostic tests are done, precluding correct treatment...
  23. ncbi request reprint Effects of admission hyperglycemia on stroke outcome in reperfused tissue plasminogen activator--treated patients
    Jose Alvarez-Sabin
    Cerebrovascular Unit, Department of Neurology, Hospital Vall d Hebron, Passeig Vall d Hebron 119 129, 08035 Barcelona, Spain
    Stroke 34:1235-41. 2003
    ..We sought to investigate the impact of hyperglycemia before reperfusion on long-term outcome in patients treated with intravenous tissue plasminogen activator (tPA)...
  24. ncbi request reprint Microbubble administration accelerates clot lysis during continuous 2-MHz ultrasound monitoring in stroke patients treated with intravenous tissue plasminogen activator
    Carlos A Molina
    Department of Neurology, Universitat Autonoma de Barcelona, Hospital Vall d Hebron, Barcelona, Spain
    Stroke 37:425-9. 2006
    ....
  25. ncbi request reprint Impact of admission hyperglycemia on stroke outcome after thrombolysis: risk stratification in relation to time to reperfusion
    Jose Alvarez-Sabin
    Neurovascular Unit, Deparment of Neurology, Hospital Universitari Vall d Hebron, Universitat Autonoma de Barcelona, Passeig Vall d Hebron 119 129, 08035 Barcelona, Spain
    Stroke 35:2493-8. 2004
    ..We evaluated the impact of admission hyperglycemia (HG) on stroke outcome in relation to the timing of reperfusion in patients treated with tissue plasminogen activator (tPA)...
  26. doi request reprint A predictive clinical-genetic model of tissue plasminogen activator response in acute ischemic stroke
    Alberto del Rio-Espinola
    Neurovascular Research Laboratory and Neurovascular Unit, Departments of Neurology and Medicine Departments, Autonomous University of Barcelona, Passeig Vall d Hebron 119 129, Barcelona, Spain
    Ann Neurol 72:716-29. 2012
    ..We aimed to find genetic variations associated with hemorrhagic transformation (HT) and mortality rates after t-PA. We then generated a clinical-genetic model for predicting t-PA response...
  27. doi request reprint ACE variants and risk of intracerebral hemorrhage recurrence in amyloid angiopathy
    Sophie Domingues-Montanari
    Neurology Department, Universitat Autonoma de Barcelona, Institute of Research, Vall d Hebron Hospital, Barcelona, Spain
    Neurobiol Aging 32:551.e13-22. 2011
    ..012). These results suggest that variants in the ACE are associated with CAA-related ICH recurrence, possibly by modulating ACE protein level...
  28. doi request reprint Fas system activation in perihematomal areas after spontaneous intracerebral hemorrhage
    Pilar Delgado
    Neurovascular Research Laboratory Hospital Vall d Hebron, Passeig Vall d Hebron 119 129, 08035 Barcelona, Spain
    Stroke 39:1730-4. 2008
    ....
  29. ncbi request reprint Tandem internal carotid artery/middle cerebral artery occlusion: an independent predictor of poor outcome after systemic thrombolysis
    Marta Rubiera
    Brain Hemodynamics Lab, Stroke Unit, Department of Neurology, Hospital Vall d Hebron, Passeig Vall d Hebron 119 129, 08035 Barcelona, Spain
    Stroke 37:2301-5. 2006
    ..Moreover, whether the relative resistance to thrombolysis in tandem lesions varies depending on the location of MCA clot remains uncertain...
  30. ncbi request reprint C-reactive protein predicts further ischemic events in first-ever transient ischemic attack or stroke patients with intracranial large-artery occlusive disease
    Juan F Arenillas
    Neurovascular Unit, Department of Neurology, Hospital Vall d Hebron, Universitat Autonoma de Barcelona, Barcelona, Spain
    Stroke 34:2463-8. 2003
    ....
  31. doi request reprint ApoA1, ApoJ and ApoE Plasma Levels and Genotype Frequencies in Cerebral Amyloid Angiopathy
    Alex Montañola
    Neurovascular Research Laboratory, Vall d Hebron Research Institute, Universitat Autonoma de Barcelona, Pg Vall d Hebron 119 129, 08035, Barcelona, Spain
    Neuromolecular Med 18:99-108. 2016
    ..023) on MRI. In summary, our findings suggest that apoA1 may act as a physiological transporter of Aβ(1-40) and that apoJ/clusterin appears to be a chaperone related to distinctive lesions in CAA brains. ..
  32. doi request reprint Lipoprotein-associated phospholipase A2 testing usefulness among patients with symptomatic intracranial atherosclerotic disease
    Andreu Massot
    Neurovascular Research Laboratory, Department of Neurology, Autonomous University of Barcelona, Vall d Hebron Hospital, Barcelona, Spain
    Atherosclerosis 218:181-7. 2011
    ....
  33. ncbi request reprint Matrix metalloproteinase-9 pretreatment level predicts intracranial hemorrhagic complications after thrombolysis in human stroke
    Joan Montaner
    Cerebrovascular Unit, Vall d Hebron Hospital, Barcelona, Spain
    Circulation 107:598-603. 2003
    ..We aimed to correlate plasmatic MMP levels with the appearance of intracranial bleeding complications in stroke patients treated with t-PA...
  34. ncbi request reprint Speed of tPA-induced clot lysis predicts DWI lesion evolution in acute stroke
    Raquel Delgado-Mederos
    Department of Neurology, Hospital Universitari Vall d Hebron, Universitat Autonoma de Barcelona, Barcelona, Spain
    Stroke 38:955-60. 2007
    ..We sought to evaluate the impact of the speed of recanalization on the evolution of diffusion- weighted imaging (DWI) lesions and outcome in stroke patients treated with tissue-type plasminogen activator (tPA)...
  35. ncbi request reprint Temporal profile of recanalization after intravenous tissue plasminogen activator: selecting patients for rescue reperfusion techniques
    Marc Ribo
    Unitat Neurovascular Hospital Vall d Hebron, Barcelona, Spain
    Stroke 37:1000-4. 2006
    ..Intravenous thrombolysis in stroke achieves arterial recanalization in approximately 50% of cases. Determining temporal profile of recanalization may address patient selection and potential benefits of further rescue reperfusion techniques...
  36. ncbi request reprint Safety and efficacy of intravenous tissue plasminogen activator stroke treatment in the 3- to 6-hour window using multimodal transcranial Doppler/MRI selection protocol
    Marc Ribo
    Unitat Neurovascular, Hospital Vall d Hebron, Universitat Autonoma de Barcelona, Spain
    Stroke 36:602-6. 2005
    ..We aim to study safety and efficacy of tPA treatment in the 3- to 6-hour window using multimodal transcranial Doppler (TCD)/MRI selection criteria...
  37. doi request reprint Lower concentrations of thrombin-antithrombin complex (TAT) correlate to higher recanalisation rates among ischaemic stroke patients treated with t-PA
    Israel Fernandez-Cadenas
    Neurovascular Research Laboratory, Neurovascular Unit Neurology Service, Departamento de Medicina, Vall d Hebron Hospital, Universitat Autonoma de Barcelona, Barcelona, Spain
    Thromb Haemost 102:759-64. 2009
    ..Low levels of TAT are not associated with an increase in haemorrhagic complications after t-PA, indicating that the combination of thrombin blockers and t-PA could be a safe and effective treatment for ischaemic stroke in the future...
  38. doi request reprint VAP-1/SSAO plasma activity and brain expression in human hemorrhagic stroke
    Mar Hernandez-Guillamon
    Neurovascular Research Laboratory, Institut de Recerca, Hospital Vall d Hebron, Barcelona, Spain
    Cerebrovasc Dis 33:55-63. 2012
    ..Our aim was to investigate the alteration of soluble VAP-1/SSAO activity in plasma samples after acute intracerebral hemorrhage (ICH) and its presence in human ICH brain tissue...
  39. doi request reprint Mobilization, endothelial differentiation and functional capacity of endothelial progenitor cells after ischemic stroke
    Míriam Navarro-Sobrino
    Neurovascular Research Laboratory, Neurovascular Unit and Neurology Department, Departament de Medicina, Universitat Autonoma de Barcelona, Vall d Hebron Hospital, Barcelona, Spain
    Microvasc Res 80:317-23. 2010
    ..Nonetheless, development of cell-based therapy for stroke will require further studies to identify those EPCs with the greatest therapeutic potential...
  40. doi request reprint Triflusal and aspirin have different effects on inflammatory biomarkers measured in patients with acute ischemic stroke
    Jose Alvarez-Sabin
    Neurovascular Research Laboratory, Vall d Hebron University Hospital, Barcelona, Spain
    Cerebrovasc Dis 28:371-7. 2009
    ..Recent experimental data (permanent middle cerebral artery occlusion in rats) have shown a possible role of triflusal in neuroprotection through inhibition of inflammatory pathways...
  41. doi request reprint C-reactive protein gene C1444T polymorphism and risk of recurrent ischemic events in patients with symptomatic intracranial atherostenoses
    Juan F Arenillas
    Neurovascular Unit, Department of Neurology, Universitat Autonoma de Barcelona, Barcelona, Spain
    Cerebrovasc Dis 28:95-102. 2009
    ..We aimed to investigate the relationship between a common genetic polymorphism of the CRP gene and the risk of recurrent ischemic events in symptomatic ICAD patients...
  42. doi request reprint Do bubble characteristics affect recanalization in stroke patients treated with microbubble-enhanced sonothrombolysis?
    Marta Rubiera
    Department of Neurology, Universitat Autonoma de Barcelona, Hospital Vall d Hebron, Barcelona, Spain
    Ultrasound Med Biol 34:1573-7. 2008
    ..However, RE rates, clinical course and long-term outcome are comparable when administering galactose-based air-filled MB (Levovist) or sulphur hexafluoride-filled MB (Sonovue)...
  43. doi request reprint Combining statins with tissue plasminogen activator treatment after experimental and human stroke: a safety study on hemorrhagic transformation
    Mireia Campos
    Neurovascular Research Laboratory, Institut de Recerca Vall d Hebron, Universitat Autonoma de Barcelona, Barcelona, Spain
    CNS Neurosci Ther 19:863-70. 2013
    ..We evaluated the safety of combining statin with tPA administration during the acute phase of both experimental and human stroke...
  44. doi request reprint Immunological biomarkers improve the accuracy of clinical risk models of infection in the acute phase of ischemic stroke
    David Salat
    Neurovascular Research Laboratory and Neurovascular Unit, Department of Neurology, Hospital Vall d Hebron, Barcelona, Spain
    Cerebrovasc Dis 35:220-7. 2013
    ..Our aim was to study whether clinical variables or changes in plasma cytokine expression can predict poststroke infections...
  45. doi request reprint Genes involved in hemorrhagic transformations that follow recombinant t-PA treatment in stroke patients
    Israel Fernandez-Cadenas
    Neurovascular Research Laboratory and Neurovascular Unit, Department of Neurology, Vall d Hebron University Hospital, Departamento de Medicina, Universitat Autonoma de Barcelona, Vall d Hebron Research Institute, 119 129, 08035 Barcelona, Spain
    Pharmacogenomics 14:495-504. 2013
    ..Despite the benefits of recombinant t-PA (rt-PA) for stroke patients some of them suffer from adverse hemorrhagic transformations (HTs) following treatment. Our objective is to study the transcriptomics of HTs patients...
  46. ncbi request reprint IL1B and VWF variants are associated with fibrinolytic early recanalization in patients with ischemic stroke
    Israel Fernandez-Cadenas
    Neurovascular Research Laboratory, Institute of Research, Vall d Hebron Hospital, Pg Vall d Hebron 119 129, 08035 Barcelona, Spain
    Stroke 43:2659-65. 2012
    ..The aim of this study was to identify genetic variants associated with recanalization, and thus treatment efficacy, after tissue-type plasminogen activator administration...
  47. doi request reprint Role of the MMP9 gene in hemorrhagic transformations after tissue-type plasminogen activator treatment in stroke patients
    Israel Fernandez-Cadenas
    Neurovascular Research Laboratory, Institut de Recerca Vall d Hebron, Barcelona, Spain
    Stroke 43:1398-400. 2012
    ..Plasma protein levels of MMP9 have been associated with HT occurrence. We aimed to analyze the association of the MMP9 gene with HT occurrence...
  48. doi request reprint Plasma β-amyloid levels in cerebral amyloid angiopathy-associated hemorrhagic stroke
    Mar Hernandez-Guillamon
    Neurovascular Research Laboratory, Institut de Recerca, Universitat Autonoma de Barcelona, Barcelona, Spain
    Neurodegener Dis 10:320-3. 2012
    ..Cerebral amyloid angiopathy (CAA) is one of the main causes of intracerebral hemorrhage (ICH) in the elderly...
  49. ncbi request reprint ACE gene polymorphisms influence t-PA-induced brain vessel reopening following ischemic stroke
    Israel Fernandez-Cadenas
    Neurovascular Research Laboratory and Neurovascular Unit, Departamento de Medicina Interna Universitat Autonoma de Barcelona, Edifici de Recerca, Vall d Hebron Hospital, Pg Vall d Hebron 119 129, 08035, Barcelona, Spain
    Neurosci Lett 398:167-71. 2006
    ..Mechanisms of benefit remain unknown since I/D polymorphism had similar FVII and X activities and PAI-1 and fibrinogen levels in our stroke population...
  50. doi request reprint Oxidative stress after thrombolysis-induced reperfusion in human stroke
    Carmen Dominguez
    Biochemistry and Molecular Biology Research Center, Hospital Universitari Vall d Hebron, Barcelona, Spain
    Stroke 41:653-60. 2010
    ..We aimed to determine the presence and role of lipid peroxidation and protein oxidation-related molecules after tissue plasminogen activator-induced recanalization in human stroke...
  51. pmc Brain perihematoma genomic profile following spontaneous human intracerebral hemorrhage
    Anna Rosell
    Neurovascular Research Laboratory and Department of Neurology, Universitat Autonoma de Barcelona, Institut de Recerca, Hospital Vall d Hebron, Barcelona, Spain
    PLoS ONE 6:e16750. 2011
    ..Spontaneous intracerebral hemorrhage (ICH) represents about 15% of all strokes and is associated with high mortality rates. Our aim was to identify the gene expression changes and biological pathways altered in the brain following ICH...
  52. pmc Cerebral ischaemia and matrix metalloproteinase-9 modulate the angiogenic function of early and late outgrowth endothelial progenitor cells
    Anna Morancho
    Neurovascular Research Laboratory, Vall d Hebron Research Institute, Universitat Autonoma de Barcelona, Barcelona, Spain
    J Cell Mol Med 17:1543-53. 2013
    ..We conclude that focal cerebral ischaemia triggers the angiogenic responses of EPCs, while MMP-9 plays a key role in the formation of vascular networks by EPCs. ..
  53. ncbi request reprint [Usefulness of urgent combined carotid/transcranial ultrasound testing in early prognosis of TIA patients]
    Francisco Purroy
    Unidad Neurovascular, Servicio de Neurologia, Hospital Vall d Hebron, Universitat Autonoma de Barcelona, Barcelona, Espana
    Med Clin (Barc) 126:647-50. 2006
    ..We investigate the value of combined carotid/transcranial ultrasound testing (UST) on the prognosis of TIA patients...
  54. pmc Factors secreted by endothelial progenitor cells enhance neurorepair responses after cerebral ischemia in mice
    Anna Rosell
    Neurovascular Research Laboratory, Department of Neurology and Department of Internal Medicine, Universitat Autonoma de Barcelona, Vall d Hebron Research Institute, Barcelona, Catalonia, Spain
    PLoS ONE 8:e73244. 2013
    ..In conclusion, we demonstrate for the first time that the administration of EPC-secreted factors could become a safe and effective cell-free option to be considered in future therapeutic strategies for stroke. ..
  55. ncbi request reprint Differential pattern of tissue plasminogen activator-induced proximal middle cerebral artery recanalization among stroke subtypes
    Carlos A Molina
    Neurovascular Unit, Department of Neurology, Hospital Vall d Hebron, Passeig Vall d Hebron 119 129, 08035 Barcelona, Spain
    Stroke 35:486-90. 2004
    ..We aimed to evaluate the timing, speed, and degree of tissue plasminogen activator (tPA)-induced recanalization in patients with proximal middle cerebral artery (MCA) occlusion of different stroke subtypes...
  56. doi request reprint Role of beta-defensin 2 and interleukin-4 receptor as stroke outcome biomarkers
    Teresa García-Berrocoso
    Neurovascular Research Laboratory, Vall d Hebron Institute of Research VHIR, Universitat Autonoma de Barcelona, Barcelona, Spain
    J Neurochem 129:463-72. 2014
    ..Both biomarkers improve the prediction of poor-outcome over clinical variables in the acute phase of stroke...
  57. doi request reprint Tissue plasminogen activator (t-PA) promotes neutrophil degranulation and MMP-9 release
    Eloy Cuadrado
    Neurovascular Research Laboratory, Neurovascular Unit, Department of Neurology, Universitat Autonoma de Barcelona, Institut de Recerca, Hospital Vall d Hebron, Pg Vall d Hebron 119 129, 08035 Barcelona, Spain
    J Leukoc Biol 84:207-14. 2008
    ..Our data suggest that neutrophils are good candidates to be the main source of MMP-9 following t-PA stroke treatment and in consequence, partially responsible for thrombolysis-related brain bleedings...
  58. ncbi request reprint Plasmatic level of neuroinflammatory markers predict the extent of diffusion-weighted image lesions in hyperacute stroke
    Joan Montaner
    Neurovascular Research Laboratory, Stroke Unit, Vall d Hebron Hospital, Barcelona, Spain
    J Cereb Blood Flow Metab 23:1403-7. 2003
    ..50, 0.25-0.74; P < 0.001). Moreover, the extent of hypoperfused brain area (PWI) was associated with a proinflammatory cytokine release in the next hours (TNF-alpha and IL-6)...
  59. ncbi request reprint Role of endogenous granulocyte-macrophage colony stimulating factor following stroke and relationship to neurological outcome
    Míriam Navarro-Sobrino
    Neurology Department, Universitat Autonoma de Barcelona, Volld Hebron Hospital, Barcelona, Spain
    Curr Neurovasc Res 6:246-51. 2009
    ..Higher plasma endogenous GM-CSF level is found in stroke patients compared to controls. However, no relation was found with a better outcome. Further research is necessary for elucidating the role of GM-CSF in ischemic stroke...
  60. doi request reprint Plasma VAP-1/SSAO activity predicts intracranial hemorrhages and adverse neurological outcome after tissue plasminogen activator treatment in stroke
    Mar Hernandez-Guillamon
    Neurovascular Research Laboratory, Institut de Recerca, Hospital Vall d Hebron, Universitat Autonoma de Barcelona, Barcelona, Spain
    Stroke 41:1528-35. 2010
    ..We aimed to study plasma VAP-1/SSAO activity in relation to the risk for intracranial bleeding complications in patients with stroke treated with tissue plasminogen activator (tPA), the greatest safety concern with this treatment...
  61. ncbi request reprint Temporal profile of matrix metalloproteinases and their inhibitors after spontaneous intracerebral hemorrhage: relationship to clinical and radiological outcome
    Jose Alvarez-Sabin
    Neurovascular Research Laboratory and the Stroke Unit, Hospital Universitario Vall d Hebron, Barcelona, Spain
    Stroke 35:1316-22. 2004
    ..We aimed to investigate the temporal profile of MMPs and their natural inhibitors (TIMPs) after acute intracerebral hemorrhage (ICH) and to study its influence on neuroimaging and clinical outcome...
  62. doi request reprint Characterization of secretomes from a human blood brain barrier endothelial cells in-vitro model after ischemia by stable isotope labeling with aminoacids in cell culture (SILAC)
    Victor Llombart
    Neurovascular Research Laboratory, Vall d Hebron Institute of Research VHIR, Universitat Autonoma de Barcelona, Barcelona, Spain Electronic address
    J Proteomics 133:100-12. 2016
    ..Western blot was used to verify the MS results in a set of 9 differentially secreted proteins and 5 of these were analyzed in serum samples of 38 ischemic stroke patients, 18 stroke-mimicking conditions and 18 healthy controls...
  63. doi request reprint From brain to blood: New biomarkers for ischemic stroke prognosis
    Teresa García-Berrocoso
    Neurovascular Research Laboratory, Vall d Hebron Institute of Research VHIR, Universitat Autonoma de Barcelona, Barcelona, Spain
    J Proteomics 94:138-48. 2013
    ..Our results indicate that early blood determination of these three biomarkers might predict outcome of patients and might help in decision-making processes related to ischemic stroke management...
  64. ncbi request reprint Plasma S100B level after acute spontaneous intracerebral hemorrhage
    Pilar Delgado
    Neurovascular Research Laboratory, Stroke Unit, Departament de Medicina, Universitat Autonoma de Barcelona, Hospital General Vall d Hebron, Barcelona, Spain
    Stroke 37:2837-9. 2006
    ..We sought to determine plasma S100B level after acute (<24 hours) spontaneous intracerebral hemorrhage (ICH) and to study its relation with neurological outcome...
  65. doi request reprint Effects of acute post-treatment with dipyridamole in a rat model of focal cerebral ischemia
    Lidia Garcia-Bonilla
    Neurovascular Research Laboratory, Institut de Recerca Vall d Hebron, Universitat Autonoma de Barcelona, Barcelona, Spain
    Brain Res 1373:211-20. 2011
    ..In selected animals, intravenous administration of high dose DP induced an adverse hypotensive effect leading to rapid death. Thus, alternative ways of acute administration must be examined in order to avoid this unfavorable effect...
  66. ncbi request reprint Increased brain expression of matrix metalloproteinase-9 after ischemic and hemorrhagic human stroke
    Anna Rosell
    Department of Neurology, Vall d Hebron University Hospital, Universitat Autonoma de Barcelona, Barcelona, Spain
    Stroke 37:1399-406. 2006
    ..We aimed to investigate MMP-2 (gelatinase A) and MMP-9 (gelatinase B) in brain parenchyma in both ischemic and hemorrhagic strokes...
  67. ncbi request reprint Prior statin use may be associated with improved stroke outcome after tissue plasminogen activator
    Jose Alvarez-Sabin
    Neurovascular Research Laboratory, Neurovascular Unit, Neurology Department, Hospital Universitario Vall d Hebron, Barcelona, Spain
    Stroke 38:1076-8. 2007
    ..The purpose of this study was to evaluate whether patients who receive tissue plasminogen activator have better outcome when statins were taken before stroke...
  68. ncbi request reprint Prediction of early neurological deterioration using diffusion- and perfusion-weighted imaging in hyperacute middle cerebral artery ischemic stroke
    Juan F Arenillas
    Cerebrovascular Unit, Vall d Hebron Hospital, Barcelona, Spain
    Stroke 33:2197-203. 2002
    ..Our study sought to assess the value of ultra-early MRI in the prediction of END in stroke patients...
  69. doi request reprint Matrix metalloproteinase-13 is activated and is found in the nucleus of neural cells after cerebral ischemia
    Eloy Cuadrado
    Department of Neurology, Institut de Recerca, Hospital Vall d Hebron, Universitat Autonoma de Barcelona, Barcelona, Spain
    J Cereb Blood Flow Metab 29:398-410. 2009
    ..Nuclear extracts from cells confirmed upregulation of active MMP-13 after OGD (P<0.05). These results suggest that MMP-13 activation and its nuclear translocation is an early consequence of an ischemic stimulus...
  70. doi request reprint Arterial blood gas analysis of samples directly obtained beyond cerebral arterial occlusion during endovascular procedures predicts clinical outcome
    Alan Flores
    Hospital Vall d Hebron, Neurology, Barcelona, Spain
    J Neuroimaging 23:180-4. 2013
    ..Real-time intra-procedure information about ischemic brain damage degree may help physicians in taking decisions about pursuing or not recanalization efforts...
  71. ncbi request reprint Admission fibrinolytic profile predicts clot lysis resistance in stroke patients treated with tissue plasminogen activator
    Marc Ribo
    Neurovascular Unit Hospital Vall d Hebron, Universitat Autonoma de Barcelona, Barcelona, Spain
    Thromb Haemost 91:1146-51. 2004
    ....
  72. ncbi request reprint Angiogenesis in symptomatic intracranial atherosclerosis: predominance of the inhibitor endostatin is related to a greater extent and risk of recurrence
    Juan F Arenillas
    Neurovascular Unit and Neurovascular Research Laboratory, Department of Neurology, Vall d Hebron Hospital, Universitat Autonoma de Barcelona, Passeig Vall d Hebron 119 129, 08035 Barcelona, Spain
    Stroke 36:92-7. 2005
    ..We aimed to investigate the relationship between the pro-angiogenic vascular endothelial growth factor (VEGF) and the anti-angiogenic endostatin, and the extent and risk of recurrence of symptomatic intracranial atherosclerosis...
  73. doi request reprint Evidence for the efficacy of statins in animal stroke models: a meta-analysis
    Lidia Garcia-Bonilla
    Neurovascular Research Laboratory, Institut de Recerca Vall d Hebron, Universitat Autonoma de Barcelona, Barcelona, Spain
    J Neurochem 122:233-43. 2012
    ..In conclusion, this meta-analysis provides further evidences of the efficacy of statins, supporting their potential use for human stroke therapy...
  74. doi request reprint Neuronal TIMP-1 release accompanies astrocytic MMP-9 secretion and enhances astrocyte proliferation induced by beta-amyloid 25-35 fragment
    Mar Hernandez-Guillamon
    Neurovascular Research Laboratory, Institut de Recerca, Hospital Universitari Vall d Hebron, Barcelona, Spain
    J Neurosci Res 87:2115-25. 2009
    ..In conclusion, our data suggest that the Abeta 25-35 fragment stimulates the MMP-9-TIMP-1 pathway, promoting gliosis, in a self-defensive attempt to eliminate amyloid deposition from AD brains...
  75. doi request reprint Ischemic stroke outcome and early infection: its deleterious effect seems to operate also among tissue plasminogen activator-treated patients
    David Salat
    Neurovascular Research Laboratory and Neurovascular Unit, Department of Neurology, Hospital Vall d Hebron, Barcelona, Spain
    Eur Neurol 65:82-7. 2011
    ....
  76. ncbi request reprint Thrombin-activable fibrinolysis inhibitor levels in the acute phase of ischemic stroke
    Joan Montaner
    Unidad Cerebrovascular, Vall d Hebron Hospital, Barcelona, Spain
    Stroke 34:1038-40. 2003
    ..The purpose of this work was to study TAFI levels in the acute phase of ischemic stroke and their relationship with stroke evolution...
  77. doi request reprint KCNK17 genetic variants in ischemic stroke
    Sophie Domingues-Montanari
    Neurovascular Research Laboratory and Neurovascular Unit, Neurology and Medicine Departments Universitat Autònoma de Barcelona, Vall d Hebron Hospital, Passeig Vall d Hebron 119 129, Barcelona, Spain
    Atherosclerosis 208:203-9. 2010
    ..In order to identify susceptibility variants, we analyzed single nucleotide polymorphisms (SNPs) that had been previously linked to stroke in a genome-wide association study...
  78. ncbi request reprint Silent myocardial ischemia in patients with symptomatic intracranial atherosclerosis: associated factors
    Juan F Arenillas
    Department of Neurology, Vall d Hebron Universitary Hospital, Passeig Vall d Hebron 119 129, 08035 Barcelona, Spain
    Stroke 36:1201-6. 2005
    ..We aimed to investigate the prevalence of silent myocardial ischemia in patients with symptomatic intracranial atherosclerosis and to identify factors associated with its presence...
  79. ncbi request reprint Pretreatment hemostatic markers of symptomatic intracerebral hemorrhage in patients treated with tissue plasminogen activator
    Dolores Cocho
    Department of Neurology, Hospital de la Santa Creu i Sant Pau, Barcelona, Spain
    Stroke 37:996-9. 2006
    ..Symptomatic intracerebral hemorrhage (ICH) is a major complication of thrombolysis in patients with acute ischemic stroke. We analyzed whether baseline hemostatic markers could predict symptomatic ICH (SICH)...
  80. ncbi request reprint [Clinical benefit following the implementation of a specialized urgent stroke care system]
    Jose Alvarez-Sabin
    Unidad Neurovascular, Servicio de Neurologia, Hospital Universitario Vall d Hebron, Barcelona, Spain
    Med Clin (Barc) 122:528-31. 2004
    ..We aimed to test the clinical efficacy of a specialized and urgent stroke assistance system in a University Hospital, as well as the specific impact of each part of the system on several clinical indicators...
  81. ncbi request reprint Higher risk of further vascular events among transient ischemic attack patients with diffusion-weighted imaging acute ischemic lesions
    Francisco Purroy
    Neurovascular Unit, Department of Neurology, Vall d Hebron Hospital, Barcelona, Spain
    Stroke 35:2313-9. 2004
    ..We investigate the value of temporal and neuroimaging data on the prognoses of TIA patients...
  82. ncbi request reprint Matrix metalloproteinase-9 concentration after spontaneous intracerebral hemorrhage
    Sonia Abilleira
    Neurovascular Unit, Department of Neurology, Hospital General Vail d Hebron, Barcelona, Spain
    J Neurosurg 99:65-70. 2003
    ..The authors investigated the MMP-9 concentration in patients after acute intracerebral hemorrhage (ICH) and its relation to perihematomal edema (PHE)...
  83. doi request reprint MMP-9-positive neutrophil infiltration is associated to blood-brain barrier breakdown and basal lamina type IV collagen degradation during hemorrhagic transformation after human ischemic stroke
    Anna Rosell
    Neurovascular Research Laboratory, Neurovascular Unit, Department of Neurology, Universitat Autonoma de Barcelona, Institut de Recerca, Hospital Vall d Hebron, Barcelona, Spain
    Stroke 39:1121-6. 2008
    ..Our aim was to investigate MMP-2 and MMP-9 in the ischemic brain and its relation with blood-brain barrier breakdown after hemorrhagic transformation in human stroke...
  84. doi request reprint Vascular MMP-9/TIMP-2 and neuronal MMP-10 up-regulation in human brain after stroke: a combined laser microdissection and protein array study
    Eloy Cuadrado
    Neurovascular Research Laboratory, Neurovascular Unit, Department of Neurology, Universitat Autonoma de Barcelona, Institut de Recerca, Hospital Vall d Hebron, Barcelona, Spain
    J Proteome Res 8:3191-7. 2009
    ..These findings demonstrate a selective cell-dependent MMP secretion, opening the possibility of selectively targeting specific MMPs for neuroprotection or vasculoprotection following stroke...
  85. doi request reprint A new method for focal transient cerebral ischaemia by distal compression of the middle cerebral artery
    Anna Morancho
    Neurovascular Research Laboratory, Department of Neurology and Department of Internal Medicine, Universitat Autonoma de Barcelona, Vall d Hebron Institut de Recerca, Barcelona, Spain
    Neuropathol Appl Neurobiol 38:617-27. 2012
    ..Rodent experimental models are essential for in vivo study of stroke. Our aim was to develop a reproducible method of mouse transient focal cerebral ischaemia by distal artery compression...
  86. ncbi request reprint Stroke biomarkers: Can they help us to guide stroke thrombolysis?
    Joan Montaner
    Neurovascular Research Laboratory, Neurology Department, Hospital Universitario Vall d Hebron, Barcelona, Spain
    Drug News Perspect 19:523-32. 2006
    ..Finally, we will also show that genetic background of stroke patients may condition plasma levels of some of these biomarkers and influence therapeutic response in t-PA-treated patients...
  87. doi request reprint Genetics of stroke: a review of recent advances
    Sophie Domingues-Montanari
    Departamento de Medicina, Neurovascular Research Laboratory and Neurovascular Unit, Universitat Autonoma de Barcelona, Institut de Recerca, Hospital Vall d Hebron, 08035 Barcelona, Spain
    Expert Rev Mol Diagn 8:495-513. 2008
    ..In the near future, understanding the contribution of stroke genetic factors will lead to improvements in prevention and treatments for neurovascular diseases...
  88. doi request reprint The proteome of human brain after ischemic stroke
    Eloy Cuadrado
    Neurovascular Research Laboratory, Neurology Department, Vall d Hebron University Hospital Research Institute, Universitat Autonoma de Barcelona, Barcelona, Spain
    J Neuropathol Exp Neurol 69:1105-15. 2010
    ..These results contribute to understanding the processes that follow cerebral ischemia; moreover, some of the identified proteins may be therapeutic targets or biologic markers for determining the diagnosis and prognosis of stroke...
  89. ncbi request reprint Blood biomarkers to guide stroke thrombolysis
    Joan Montaner
    Neurovascular Research Laboratory, Neurovascular Unit, Neurology Department, Hospital Universitario Vall d Hebron, Barcelona, Spain
    Front Biosci (Elite Ed) 1:200-8. 2009
    ..We will also show that the genetic background of stroke patients might condition plasma levels of some of those biomarkers and influence the therapeutic response in t-PA treated...
  90. doi request reprint Statin use before and after acute ischemic stroke onset improves neurological outcome
    David Salat
    Neurovascular Research Laboratory, Neurovascular Unit, Institut de Recerca, Hospital Vall d Hebron, Pg Vall d Hebron 119 129, 08035 Barcelona, Spain
    Expert Rev Cardiovasc Ther 7:1219-30. 2009
    ....
  91. doi request reprint Metalloproteinase and stroke infarct size: role for anti-inflammatory treatment?
    Anna Morancho
    Neurovascular Research Laboratory, Neurology Department, Hospital Universitari Vall d Hebron, Institut de Recerca, Universitat Autonoma de Barcelona, Spain
    Ann N Y Acad Sci 1207:123-33. 2010
    ....
  92. ncbi request reprint Latest advances and research in stroke treatment 2007
    Joan Montaner
    Neurovascular Research Laboratory, Neurovascular Unit, Vall d Hebron University Hospital, Barcelona, Spain
    Drug News Perspect 20:197-208. 2007
    ..Also covered in this review are a selection of advances introduced in secondary prevention and in cerebral hemorrhage...
  93. doi request reprint CADASIL management or what to do when there is little one can do
    Alberto del Rio-Espinola
    Neurovascular Research Laboratory and Neurovascular Unit, Vall d Hebron Hospital, Neurology Department Universitat Autònoma de Barcelona, Spain
    Expert Rev Neurother 9:197-210. 2009
    ..This review focuses on an update of CADASIL management, based on the recent clinical and basic evidence, and discusses possible new treatment targets for CADASIL...
  94. ncbi request reprint Intraplaque MMP-8 levels are increased in asymptomatic patients with carotid plaque progression on ultrasound
    Marta Miguel Turu
    Cardiovascular Research Center, IIBB CSIC HSCSP UAB, Barcelona, Spain
    Atherosclerosis 187:161-9. 2006
    ..03, CI 95% 0.7-1.0). Hypoechogenic carotid plaques had increased MMP activity and asymptomatic patients with plaque progression show increase intraplaque MMP-8 levels...
  95. doi request reprint Moderate and severe traumatic brain injury induce early overexpression of systemic and brain gelatinases
    Anna Vilalta
    Neurotraumatology and Neurosurgery Research Unit, Vall d Hebron University Hospital, Universitat Autonoma de Barcelona, Passeig Vall d Hebron 119 129, 08035, Barcelona, Spain
    Intensive Care Med 34:1384-92. 2008
    ..We examined the acute profile of MMP-2 and MMP-9 in the plasma of patients with moderate or severe TBI and in the brain extracellular fluid (ECF)...