Juan Mendez

Summary

Country: Spain

Publications

  1. pmc Molecular architecture of the human GINS complex
    Jasminka Boskovic
    Structural Biology and Biocomputing Programme, Macromolecular Crystallography Group, Spanish National Cancer Research Center CNIO, Madrid, Spain
    EMBO Rep 8:678-84. 2007
  2. doi request reprint Temporal regulation of DNA replication in mammalian cells
    Juan Mendez
    DNA replication Group, Molecular Oncology Programme, Spanish National Cancer Research Centre CNIO, Madrid, Spain
    Crit Rev Biochem Mol Biol 44:343-51. 2009
  3. pmc Cohesin organizes chromatin loops at DNA replication factories
    Emmanuelle Guillou
    DNA replication Group, Spanish National Cancer Research Centre CNIO, E 28029 Madrid, Spain
    Genes Dev 24:2812-22. 2010
  4. pmc Molecular architecture of a multifunctional MCM complex
    June Sanchez-Berrondo
    Structural Biology and Biocomputing Programme, Macromolecular Crystallography Group, Spanish National Cancer Research Center CNIO, c Melchor Fdez Almagro 3, 28029 Madrid, Spain
    Nucleic Acids Res 40:1366-80. 2012
  5. pmc USP7 is a SUMO deubiquitinase essential for DNA replication
    Emilio Lecona
    Genomic Instability Group, Spanish National Cancer Research Centre CNIO, Madrid, Spain
    Nat Struct Mol Biol 23:270-7. 2016
  6. doi request reprint Visualization of the MCM DNA helicase at replication factories before the onset of DNA synthesis
    Tomas Aparicio
    DNA replication Group, Molecular Oncology Programme, Spanish National Cancer Research Centre CNIO, Melchor Fernandez Almagro, 3, 28029, Madrid, Spain
    Chromosoma 121:499-507. 2012
  7. pmc The human GINS complex associates with Cdc45 and MCM and is essential for DNA replication
    Tomas Aparicio
    DNA replication Group, Molecular Oncology Programme, Spanish National Cancer Research Center CNIO, Madrid, Spain
    Nucleic Acids Res 37:2087-95. 2009
  8. doi request reprint Repriming of DNA synthesis at stalled replication forks by human PrimPol
    Silvana Mouron
    Molecular Oncology Program, Spanish National Cancer Research Centre, Madrid, Spain
    Nat Struct Mol Biol 20:1383-9. 2013
  9. pmc Excess MCM proteins protect human cells from replicative stress by licensing backup origins of replication
    Arkaitz Ibarra
    DNA replication Group, Molecular Oncology Programme, Spanish National Cancer Research Centre CNIO, Melchor Fernandez Almagro, 3 E 28029 Madrid, Spain
    Proc Natl Acad Sci U S A 105:8956-61. 2008
  10. pmc NSMCE2 suppresses cancer and aging in mice independently of its SUMO ligase activity
    Ariana Jacome
    Genomic Instability Group, Spanish National Cancer Research Centre, Madrid, Spain
    EMBO J 34:2604-19. 2015

Collaborators

Detail Information

Publications18

  1. pmc Molecular architecture of the human GINS complex
    Jasminka Boskovic
    Structural Biology and Biocomputing Programme, Macromolecular Crystallography Group, Spanish National Cancer Research Center CNIO, Madrid, Spain
    EMBO Rep 8:678-84. 2007
    ..The structure and DNA-binding data suggest how GINS could interact with DNA and also its possible role in the CMG helicase complex...
  2. doi request reprint Temporal regulation of DNA replication in mammalian cells
    Juan Mendez
    DNA replication Group, Molecular Oncology Programme, Spanish National Cancer Research Centre CNIO, Madrid, Spain
    Crit Rev Biochem Mol Biol 44:343-51. 2009
    ..This review covers our current understanding of the mechanisms that determine RT in mammalian cells, its possible biological significance and how unscheduled alterations of the RT program may predispose to human disease...
  3. pmc Cohesin organizes chromatin loops at DNA replication factories
    Emmanuelle Guillou
    DNA replication Group, Spanish National Cancer Research Centre CNIO, E 28029 Madrid, Spain
    Genes Dev 24:2812-22. 2010
    ..These results give a new dimension to the role of cohesin in the architectural organization of interphase chromatin, by showing its participation in DNA replication...
  4. pmc Molecular architecture of a multifunctional MCM complex
    June Sanchez-Berrondo
    Structural Biology and Biocomputing Programme, Macromolecular Crystallography Group, Spanish National Cancer Research Center CNIO, c Melchor Fdez Almagro 3, 28029 Madrid, Spain
    Nucleic Acids Res 40:1366-80. 2012
    ....
  5. pmc USP7 is a SUMO deubiquitinase essential for DNA replication
    Emilio Lecona
    Genomic Instability Group, Spanish National Cancer Research Centre CNIO, Madrid, Spain
    Nat Struct Mol Biol 23:270-7. 2016
    ....
  6. doi request reprint Visualization of the MCM DNA helicase at replication factories before the onset of DNA synthesis
    Tomas Aparicio
    DNA replication Group, Molecular Oncology Programme, Spanish National Cancer Research Centre CNIO, Melchor Fernandez Almagro, 3, 28029, Madrid, Spain
    Chromosoma 121:499-507. 2012
    ..Most MCM complexes are released from chromatin, except for a small but detectable fraction that remains at the forks during the S phase, as expected for a replicative helicase...
  7. pmc The human GINS complex associates with Cdc45 and MCM and is essential for DNA replication
    Tomas Aparicio
    DNA replication Group, Molecular Oncology Programme, Spanish National Cancer Research Center CNIO, Madrid, Spain
    Nucleic Acids Res 37:2087-95. 2009
    ..Down-regulation of hGINS destabilizes CMG, causes a G1-S arrest and slows down ongoing DNA replication, effectively blocking cell proliferation. Our data support the notion that hGINS is an essential component of the human replisome...
  8. doi request reprint Repriming of DNA synthesis at stalled replication forks by human PrimPol
    Silvana Mouron
    Molecular Oncology Program, Spanish National Cancer Research Centre, Madrid, Spain
    Nat Struct Mol Biol 20:1383-9. 2013
    ..As an enzyme involved in tolerance to DNA damage, PrimPol might become a target for cancer therapy. ..
  9. pmc Excess MCM proteins protect human cells from replicative stress by licensing backup origins of replication
    Arkaitz Ibarra
    DNA replication Group, Molecular Oncology Programme, Spanish National Cancer Research Centre CNIO, Melchor Fernandez Almagro, 3 E 28029 Madrid, Spain
    Proc Natl Acad Sci U S A 105:8956-61. 2008
    ..Our data show that the chromatin-bound "excess" Mcm2-7 complexes play an important role in maintaining genomic integrity under conditions of replicative stress...
  10. pmc NSMCE2 suppresses cancer and aging in mice independently of its SUMO ligase activity
    Ariana Jacome
    Genomic Instability Group, Spanish National Cancer Research Centre, Madrid, Spain
    EMBO J 34:2604-19. 2015
    ..Our work reveals that SUMO- and BLM-independent activities of NSMCE2 limit recombination and facilitate segregation; functions of the SMC5/6 complex that are necessary to prevent cancer and aging in mice. ..
  11. pmc Cdc45-MCM-GINS, a new power player for DNA replication
    Tomas Aparicio
    DNA replication Group, Molecular Oncology Programme, Spanish National Cancer Center CNIO, Melchor Fernandez Almagro 3, E 28029 Madrid, Spain
    Cell Div 1:18. 2006
    ..The Cdc45-MCM-GINS complex could constitute the core of a larger macromolecular structure that has been termed the "replisome progression complex"...
  12. doi request reprint Genomic stability and tumour suppression by the APC/C cofactor Cdh1
    Irene Garcia-Higuera
    Cell Division and Cancer Group, Centro Nacional de Investigaciones Oncologicas CNIO, Madrid, Spain
    Nat Cell Biol 10:802-11. 2008
    ..These results indicate that Cdh1 is required for preventing unscheduled proliferation of specific progenitor cells and protecting mammalian cells from genomic instability...
  13. doi request reprint Functional reprogramming of polyploidization in megakaryocytes
    Marianna Trakala
    Cell Division and Cancer Group, Spanish National Cancer Research Centre CNIO, 28029 Madrid, Spain
    Dev Cell 32:155-67. 2015
    ..These findings suggest that endomitosis can be functionally replaced by alternative polyploidization mechanisms in vivo and provide the cellular basis for therapeutic approaches aimed to discriminate mitotic and polyploid cells...
  14. ncbi request reprint Oncogenic activity of Cdc6 through repression of the INK4/ARF locus
    Susana Gonzalez
    Tumor Suppression Group, Spanish National Cancer Research Center CNIO, E 28029 Madrid, Spain
    Nature 440:702-6. 2006
    ..We conclude that aberrant expression of Cdc6 is oncogenic by directly repressing the INK4/ARF locus through the RD(INK4/ARF) element...
  15. ncbi request reprint DNA replication stress: from molecular mechanisms to human disease
    Sergio Munoz
    DNA replication Group, Molecular Oncology Programme, Spanish National Cancer Research Centre CNIO, Melchor Fernandez Almagro 3, E 28029, Madrid, Spain
    Chromosoma . 2016
    ....
  16. pmc Molecular architecture of the recombinant human MCM2-7 helicase in complex with nucleotides and DNA
    Jasminka Boskovic
    a Structural Biology and Biocomputing Programme, Spanish National Cancer Research Centre CNIO, Macromolecular Crystallography Group, c Melchor Fdez Almagro 3, Madrid, Spain
    Cell Cycle 15:2431-40. 2016
    ....
  17. pmc Replication stress caused by low MCM expression limits fetal erythropoiesis and hematopoietic stem cell functionality
    Silvia Alvarez
    DNA replication Group, Spanish National Cancer Research Centre CNIO, Melchor Fernandez Almagro, 3, 28029 Madrid, Spain
    Nat Commun 6:8548. 2015
    ..Our results indicate that hematopoietic progenitors are particularly sensitive to replication stress, and full origin licensing ensures their correct differentiation and functionality. ..
  18. ncbi request reprint CDC6: from DNA replication to cell cycle checkpoints and oncogenesis
    Luis R Borlado
    DNA replication Group, Molecular Oncology Programme, Spanish National Cancer Research Centre, Melchor Fernandez Almagro 3, E 28029 Madrid, Spain
    Carcinogenesis 29:237-43. 2008
    ..These findings indicate that deregulation of CDC6 expression in human cells poses a serious risk of carcinogenesis...