Armando Lopez-Guillermo

Summary

Country: Spain

Publications

  1. ncbi request reprint Successful treatment of isolated cutaneous relapse of follicular lymphoma with rituximab
    A Ferrer
    Department of Hematology, Institut d Investigacions Biomediques August Pi i Sunyer, Hospital Clinic, Barcelona, Spain
    Ann Hematol 80:479-81. 2001
  2. doi request reprint Clinical practice guidelines for first-line/after-relapse treatment of patients with follicular lymphoma
    Armando Lopez-Guillermo
    Hematology Department, Hospital Clinic de Barcelona, Barcelona, Spain
    Leuk Lymphoma 52:1-14. 2011
  3. ncbi request reprint Diffuse large B-cell lymphoma: clinical and biological characterization and outcome according to the nodal or extranodal primary origin
    Armando Lopez-Guillermo
    Department of Hematology, Hospital Clinic, Villarroel 170, 08036 Barcelona, Spain
    J Clin Oncol 23:2797-804. 2005
  4. ncbi request reprint Primary follicular lymphoma arising in the ampulla of Vater
    E Nadal
    Institute of Hematology and Oncology, Hematology Department, IDIBAPS, Hospital Clinic, Villarroel 170, 08036 Barcelona, Spain
    Ann Hematol 81:228-31. 2002
  5. ncbi request reprint Salvage treatment with etoposide (VP-16), ifosfamide and cytarabine (Ara-C) for patients with recurrent primary central nervous system lymphoma
    Eduardo Arellano-Rodrigo
    Service of Hematology, Institut de Recerca Biomèdica August Pi i Sunyer, Hospital Clinic, Barcelona, Spain
    Eur J Haematol 70:219-24. 2003
  6. ncbi request reprint Incidence and clinical significance of bcl-2/IgH rearrangements in follicular lymphoma
    Silvia Montoto
    Hematology Department, Institute of Hematology and Oncology, Postgraduate School of Hematology Farrers Valenti Institut d Investigacions Biomèdiques August Pi i Sunyer, Hospital Clinic of Barcelona, Villarroel 170, 08036 Barcelona, Spain
    Leuk Lymphoma 44:71-6. 2003
  7. ncbi request reprint Allogeneic stem-cell transplantation may overcome the adverse prognosis of unmutated VH gene in patients with chronic lymphocytic leukemia
    Carol Moreno
    Department of Hematology, Institute of Hematology and Oncology, Hospital Clinic, Villarroel, 170, 08036 Barcelona, Spain
    J Clin Oncol 23:3433-8. 2005
  8. doi request reprint Clinico-biological characterization and outcome of primary nodal and extranodal diffuse large B-cell lymphoma in the rituximab era
    Gonzalo Gutierrez-García
    Department of Hematology, Hospital Clinic, Institut de Recerca Biomèdica August Pi i Sunyer, Barcelona, Spain
    Leuk Lymphoma 51:1225-32. 2010
  9. ncbi request reprint Leukemic involvement is a common feature in mantle cell lymphoma
    Ana Ferrer
    Department of Hematology, Hospital Clinic, University of Barcelona, IDIBAPS, Barcelona, Spain
    Cancer 109:2473-80. 2007
  10. ncbi request reprint Clinical impact of the differentiation profile assessed by immunophenotyping in patients with diffuse large B-cell lymphoma
    Lluis Colomo
    Department of Pathology, Hospital Clinic, Institut de Recerca Biomèdica August Pi i Sunyer, University of Barcelona, Spain
    Blood 101:78-84. 2003

Detail Information

Publications76

  1. ncbi request reprint Successful treatment of isolated cutaneous relapse of follicular lymphoma with rituximab
    A Ferrer
    Department of Hematology, Institut d Investigacions Biomediques August Pi i Sunyer, Hospital Clinic, Barcelona, Spain
    Ann Hematol 80:479-81. 2001
    ..The patient, who had relapsed after three lines of chemotherapy, was treated with the chimeric anti-CD20 antibody, rituximab, achieving a complete response, which has now persisted for more than 24 months...
  2. doi request reprint Clinical practice guidelines for first-line/after-relapse treatment of patients with follicular lymphoma
    Armando Lopez-Guillermo
    Hematology Department, Hospital Clinic de Barcelona, Barcelona, Spain
    Leuk Lymphoma 52:1-14. 2011
    ..These guidelines provide healthcare professionals with updated and consensual tools for the better management of patients with follicular lymphoma...
  3. ncbi request reprint Diffuse large B-cell lymphoma: clinical and biological characterization and outcome according to the nodal or extranodal primary origin
    Armando Lopez-Guillermo
    Department of Hematology, Hospital Clinic, Villarroel 170, 08036 Barcelona, Spain
    J Clin Oncol 23:2797-804. 2005
    ..To study the main clinicobiologic features, response, and outcome of patients with diffuse large B-cell lymphoma (DLBCL) according to the primary site, lymph node, or different extranodal organs of the disease...
  4. ncbi request reprint Primary follicular lymphoma arising in the ampulla of Vater
    E Nadal
    Institute of Hematology and Oncology, Hematology Department, IDIBAPS, Hospital Clinic, Villarroel 170, 08036 Barcelona, Spain
    Ann Hematol 81:228-31. 2002
    ..After 2 years of follow-up he remains asymptomatic and the gastroendoscopic study is normal...
  5. ncbi request reprint Salvage treatment with etoposide (VP-16), ifosfamide and cytarabine (Ara-C) for patients with recurrent primary central nervous system lymphoma
    Eduardo Arellano-Rodrigo
    Service of Hematology, Institut de Recerca Biomèdica August Pi i Sunyer, Hospital Clinic, Barcelona, Spain
    Eur J Haematol 70:219-24. 2003
    ..However, the prognosis of patients who fail or relapse after initial response is poor. Very little data is available on salvage treatment at recurrence...
  6. ncbi request reprint Incidence and clinical significance of bcl-2/IgH rearrangements in follicular lymphoma
    Silvia Montoto
    Hematology Department, Institute of Hematology and Oncology, Postgraduate School of Hematology Farrers Valenti Institut d Investigacions Biomèdiques August Pi i Sunyer, Hospital Clinic of Barcelona, Villarroel 170, 08036 Barcelona, Spain
    Leuk Lymphoma 44:71-6. 2003
    ..In our series bcl-2/IgH rearrangement at MBR or mcr, which was found in 67% of the patients, was not correlated with response to treatment, survival nor time-to-treatment-failure...
  7. ncbi request reprint Allogeneic stem-cell transplantation may overcome the adverse prognosis of unmutated VH gene in patients with chronic lymphocytic leukemia
    Carol Moreno
    Department of Hematology, Institute of Hematology and Oncology, Hospital Clinic, Villarroel, 170, 08036 Barcelona, Spain
    J Clin Oncol 23:3433-8. 2005
    ..To investigate whether allogeneic stem-cell transplantation (allo-SCT) may overcome the negative impact of unmutated VH genes in the outcome of patients with chronic lymphocytic leukemia (CLL)...
  8. doi request reprint Clinico-biological characterization and outcome of primary nodal and extranodal diffuse large B-cell lymphoma in the rituximab era
    Gonzalo Gutierrez-García
    Department of Hematology, Hospital Clinic, Institut de Recerca Biomèdica August Pi i Sunyer, Barcelona, Spain
    Leuk Lymphoma 51:1225-32. 2010
    ....
  9. ncbi request reprint Leukemic involvement is a common feature in mantle cell lymphoma
    Ana Ferrer
    Department of Hematology, Hospital Clinic, University of Barcelona, IDIBAPS, Barcelona, Spain
    Cancer 109:2473-80. 2007
    ..The aim of the study was to analyze the prevalence and the biologic and clinical significance of leukemic involvement in a series of patients with MCL...
  10. ncbi request reprint Clinical impact of the differentiation profile assessed by immunophenotyping in patients with diffuse large B-cell lymphoma
    Lluis Colomo
    Department of Pathology, Hospital Clinic, Institut de Recerca Biomèdica August Pi i Sunyer, University of Barcelona, Spain
    Blood 101:78-84. 2003
    ..In conclusion, differentiation profile was associated with particular clinicopathological features but was not essential to predicting outcome in DLBCL patients...
  11. ncbi request reprint ZAP-70 expression as a surrogate for immunoglobulin-variable-region mutations in chronic lymphocytic leukemia
    Marta Crespo
    Department of Hematology, Institut d Investigacions Biom diques August Pi i Sunyer, Hospital Cl nic, Barcelona, Spain
    N Engl J Med 348:1764-75. 2003
    ..We investigated whether the expression of ZAP-70 by CLL cells correlated with the IgVH mutational status, disease progression, and survival...
  12. ncbi request reprint Follicular lymphoma in early stages: high risk of relapse and usefulness of the Follicular Lymphoma International Prognostic Index to predict the outcome of patients
    Francisco Plancarte
    Department of Hematology, Hospital Clinic, Barcelona, Spain
    Eur J Haematol 76:58-63. 2006
    ..The objective of this study was to analyze the clinical features and the outcome of a series of patients with FL in early stages with a long follow-up...
  13. ncbi request reprint CDK4 and MDM2 gene alterations mainly occur in highly proliferative and aggressive mantle cell lymphomas with wild-type INK4a/ARF locus
    Luis Hernandez
    Department of Pathology and Hematology, Hospital Clinic, Institut d Investigacions Biomediques August Pi i Sunyer, University of Barcelona, Barcelona, Spain
    Cancer Res 65:2199-206. 2005
    ..These findings indicate that CDK4 and MDM2 gene alterations mainly occur in MCL with a wild-type INK4a/ARF locus and may contribute to the higher proliferation and more aggressive behavior of the tumors...
  14. pmc Identification of methylated genes associated with aggressive clinicopathological features in mantle cell lymphoma
    Anna Enjuanes
    Hematopathology Section, Department of Anatomic Pathology, Hospital Clinic, Institut d Investigacions Biomediques August Pi i Sunyer, University of Barcelona, Barcelona, Spain
    PLoS ONE 6:e19736. 2011
    ..The contribution of DNA methylation to MCL lymphomagenesis is not well known. We sought to identify epigenetically silenced genes in these tumours that might have clinical relevance...
  15. ncbi request reprint Fludarabine, cyclophosphamide and mitoxantrone in the treatment of resistant or relapsed chronic lymphocytic leukaemia
    Francesc Bosch
    Department of Haematology, Institut d Investigacions Biomediques August Pi i Sunyer IDIBAPS, Hospital Clinic, Department of Haematology, Hospital de Sant Pau, Barcelona, Spain
    Br J Haematol 119:976-84. 2002
    ..FCM did not hamper stem cell harvesting in patients who were candidates for autologous stem cell transplantation. FCM induced a high CR rate, including an important number of MRD(-), in patients with previously treated CLL...
  16. ncbi request reprint CHK2-decreased protein expression and infrequent genetic alterations mainly occur in aggressive types of non-Hodgkin lymphomas
    Frederic Tort
    Laboratory of Pathology, Hospital Clinic, Institut d Investigacions Biomediques August Pi i Sunyer IDIBAPS, University of Barcelona, Spain
    Blood 100:4602-8. 2002
    ..The high number of chromosomal imbalances in tumors with complete absence of CHK2 protein suggests a role of this gene in chromosomal instability in human lymphomas...
  17. ncbi request reprint Spontaneous and drug-induced apoptosis is mediated by conformational changes of Bax and Bak in B-cell chronic lymphocytic leukemia
    Beatriz Bellosillo
    Department of Hematology, Institute of Hematology and Oncology from Hospital Clínic, Postgraduate School of Hematology Farreras Valenti, Barcelona, Spain
    Blood 100:1810-6. 2002
    ..These results demonstrate that, in CLL cells, the change in the intracellular localization of Bax from cytosol to mitochondria and the conformational changes of Bax and Bak are among the early steps in the induction of cell death...
  18. doi request reprint Clonal evolution in chronic lymphocytic leukemia: analysis of correlations with IGHV mutational status, NOTCH1 mutations and clinical significance
    Cristina Lopez
    Hematopathology Unit, Department of Pathology, Hospital Clinic, Institut d Investigacions Biomediques August Pi i Sunyer IDIBAPS, University of Barcelona, Barcelona, Spain
    Genes Chromosomes Cancer 52:920-7. 2013
    ..The combination of conventional and molecular cytogenetics increased the detection of CE, this phenomenon probably being a reflection of genomic instability and conferring a more aggressive clinical course...
  19. doi request reprint Retreatment with purine analogs in patients with chronic lymphocytic leukemia
    Ivan Dlouhy
    Institute of Hematology and Oncology, Department of Hematology, Hospital Clinic, Barcelona, Spain
    Leuk Res 36:1521-5. 2012
    ..Second malignancies were observed in 10 (16%) patients. Our results outline that retreatment with PA is remarkably effective in patients with relapsed CLL, but with a significant toxicity...
  20. ncbi request reprint Immunohistochemical analysis of ZAP-70 expression in B-cell lymphoid neoplasms
    Joaquim Carreras
    Haemopathology Unit, Department of Pathology, Hospital Clinic, Institut d Investigacions Biomediques August Pi i Sunyer, Barcelona, Spain
    J Pathol 205:507-13. 2005
    ....
  21. ncbi request reprint Abdominal computed tomography predicts progression in patients with Rai stage 0 chronic lymphocytic leukemia
    Ana Muntañola
    Department of Hematology, Institut d Investigacions Biomediques August Pi i Sunyer IDIBAPS, Hospital Clinic, University of Barcelona, Barcelona, Spain
    J Clin Oncol 25:1576-80. 2007
    ..The aim of this study was to analyze the prognostic significance of abdominal CT in patients with CLL in Rai clinical stage 0...
  22. pmc The expression of the endoplasmic reticulum stress sensor BiP/GRP78 predicts response to chemotherapy and determines the efficacy of proteasome inhibitors in diffuse large b-cell lymphoma
    Ana Mozos
    Department of Hematopathology, Hospital Clinic, IDIBAPS, University of Barcelona, Barcelona, Spain
    Am J Pathol 179:2601-10. 2011
    ..Moreover, this study provides preclinical evidence that the germinal center B-cell-like subtype DLBCL is sensitive to bortezomib combined with immunochemotherapy...
  23. doi request reprint Genomic and gene expression profiling defines indolent forms of mantle cell lymphoma
    Veronica Fernandez
    Hematopathology Section, Department of Pathology, Hospital Clinic, Institut d Investigacions Biomediques August Pi i Sunyer and Department of Hematology, Hospital Clinic, University of Barcelona, 08036 Barcelona, Spain
    Cancer Res 70:1408-18. 2010
    ....
  24. ncbi request reprint Clinicopathologic significance and prognostic value of chromosomal imbalances in diffuse large B-cell lymphomas
    Silvia Bea
    Laboratory of Pathology and Hematology Department, Hospital Clinic, Institut d Investigactions Biomediques August Pi I Sunyer, University of Barcelona, Spain
    J Clin Oncol 22:3498-506. 2004
    ..To determine the clinicopathologic significance and prognostic value of chromosomal imbalances in diffuse large B-cell lymphomas (DLBCL)...
  25. ncbi request reprint High-dose infusional ifosfamide, etoposide plus methylprednisolone followed by dexamethasone, high-dose ara-C and cisplatinum and autologous stem cell transplantation for refractory or relapsed aggressive non-Hodgkin's lymphoma
    Antonio Salar
    Department of Clinical Hematology from Hospital del Mar, Hospital de la Santa Cruz y San Pablo, Hospital Germans Trias i Pujol, Hospital Clinic, Barcelona, Spain
    Haematologica 87:1028-35. 2002
    ..A salvage program including infusional high-dose ifosfamide plus etoposide (IFOVM) was evaluated in patients with refractory or relapsed aggressive non-Hodgkin's lymphoma...
  26. ncbi request reprint High numbers of tumor-infiltrating FOXP3-positive regulatory T cells are associated with improved overall survival in follicular lymphoma
    Joaquim Carreras
    Hematopathology Section, Department of Pathology, Hospital Clinic, IDIBAPS, University of Barcelona, Barcelona, Spain
    Blood 108:2957-64. 2006
    ..3%) than FL grades 1,2 (mean: 12.1%) or 3 (mean: 9%) (P < .02). In conclusion, high Treg numbers predict improved survival of FL patients, while a marked reduction in Tregs is observed on transformation to DLBCL...
  27. doi request reprint MYD88 L265P Mutations, But No Other Variants, Identify a Subpopulation of DLBCL Patients of Activated B-cell Origin, Extranodal Involvement, and Poor Outcome
    Jordina Rovira
    Hematology Department, Hospital Clinic, IDIBAPS, Barcelona, Spain
    Clin Cancer Res 22:2755-64. 2016
    ..The aim of this study was to analyze the incidence of MYD88 mutations and its clinical impact in diffuse large B-cell lymphoma (DLBCL)...
  28. ncbi request reprint T-cell subsets in lymph nodes identify a subgroup of follicular lymphoma patients with favorable outcome
    Laura Magnano
    a Department of Hematology, Hospital Clinic, Institut d Investigacions Biomediques August Pi i Sunyer IDIBAPS, Barcelona, Spain
    Leuk Lymphoma . 2016
    ..In conclusion, T-cell subpopulations, including CD4+CD57+/CD4+ ratio analyzed by FC, could identify FL patients with favorable outcome...
  29. doi request reprint Genome-wide methylation analyses identify a subset of mantle cell lymphoma with a high number of methylated CpGs and aggressive clinicopathological features
    Anna Enjuanes
    Genomics Unit, Institut d Investigacions Biomediques August Pi i Sunyer, University of Barcelona, Barcelona, Spain
    Int J Cancer 133:2852-63. 2013
    ....
  30. doi request reprint Incidence and prognostic impact of secondary cytogenetic aberrations in a series of 145 patients with mantle cell lymphoma
    Blanca Espinet
    Laboratori de Citogenètica Molecular, Laboratori de Citologia Hematologica, Servei de Patologia, Servei d Hematologia Clinica, GRETNHE, IMIM Hospital del Mar, Barcelona, Spain
    Genes Chromosomes Cancer 49:439-51. 2010
    ..Additionally, we observed that 3q gains and 17p losses detected by conventional cytogenetics are proliferation-independent prognostic markers indicating poor outcome...
  31. doi request reprint High clinical and molecular response rates with fludarabine, cyclophosphamide and mitoxantrone in previously untreated patients with advanced stage follicular lymphoma
    Silvia Montoto
    Department of Hematology, Hospital Clinic, IDIBAPS, Barcelona, Spain
    Haematologica 93:207-14. 2008
    ..The aim of this study was to analyze the efficacy and toxicity of a fludarabine combination as first-line treatment in patients with advanced-stage disease...
  32. ncbi request reprint Diffuse large B-cell lymphomas with plasmablastic differentiation represent a heterogeneous group of disease entities
    Lluis Colomo
    Hematopathology Section, Laboratory of Pathology, and Department of Hematology, Hospital Clinic, Institut d Investigacions Biomediques August Pi i Sunyer, University of Barcelona, Barcelona, Spain
    Am J Surg Pathol 28:736-47. 2004
    ..In conclusion, DLBCLs with plasmablastic differentiation are a heterogeneous group of neoplasms with different clinicopathological characteristics that may correspond to different entities...
  33. pmc Expanded and highly active proliferation centers identify a histological subtype of chronic lymphocytic leukemia ("accelerated" chronic lymphocytic leukemia) with aggressive clinical behavior
    Eva Gine
    Department of Hematology, Hospital Clínic Villarroel n masculine 170, 08036 Barcelona, Spain
    Haematologica 95:1526-33. 2010
    ..However, neither histological criteria to define this form of chronic lymphocytic leukemia nor its clinical correlates and prognostic impact have been formally defined in large series of patients...
  34. doi request reprint Long-term safety and outcome of fludarabine, cyclophosphamide and mitoxantrone (FCM) regimen in previously untreated patients with advanced follicular lymphoma: 12 years follow-up of a phase 2 trial
    Laura Magnano
    Department of Hematology, Hospital Clinic, IDIBAPS, CIBERONC, Villarroel, 170, 08036, Barcelona, Spain
    Ann Hematol . 2017
    ..In conclusion, FCM regimen allows excellent long-lasting response in previously untreated patients with FL. The incidence of late events including histological transformation and secondary neoplasia is low but not negligible...
  35. pmc Clinical impact of clonal and subclonal TP53, SF3B1, BIRC3, NOTCH1, and ATM mutations in chronic lymphocytic leukemia
    Ferran Nadeu
    Lymphoid Neoplasm Program, Institut d Investigacions Biomediques August Pi i Sunyer IDIBAPS, Barcelona, Spain
    Blood 127:2122-30. 2016
    ..These findings suggest that the characterization of the subclonal architecture and its dynamics in the evolution of the disease may be relevant for the management of CLL patients. ..
  36. pmc Prognosis of patients with diffuse large B cell lymphoma not reaching complete response or relapsing after frontline chemotherapy or immunochemotherapy
    Jordina Rovira
    Hematology Department, Hospital Clinic, IDIBAPS, C Villarroel, 170, 08036, Barcelona, Spain
    Ann Hematol 94:803-12. 2015
    ..In conclusion, relapsed/refractory patients with DLBCL show poor prognosis despite the use of frontline immunochemotherapy. New therapeutic approaches are needed in this group of patients...
  37. doi request reprint In vivo intratumoral Epstein-Barr virus replication is associated with XBP1 activation and early-onset post-transplant lymphoproliferative disorders with prognostic implications
    Blanca Gonzalez-Farre
    Department of Pathology, Hospital Clinic, Institut d Investigacions Biomediques August Pi i Sunyer IDIBAPS, University of Barcelona, Barcelona, Spain
    Mod Pathol 27:1599-611. 2014
    ..These results suggest that immunohistochemical study of latent and lytic EBV genes in the clinical practice may help to select higher-risk patients to new therapies including antiviral treatments. ..
  38. pmc Landscape of somatic mutations and clonal evolution in mantle cell lymphoma
    Silvia Bea
    Institut d Investigacions Biomediques August Pi i Sunyer, Hospital Clinic, Universitat de Barcelona, 08036 Barcelona, Spain
    Proc Natl Acad Sci U S A 110:18250-5. 2013
    ..Our study identifies molecular mechanisms contributing to MCL pathogenesis and offers potential targets for therapeutic intervention. ..
  39. doi request reprint Gene-expression profiling and not immunophenotypic algorithms predicts prognosis in patients with diffuse large B-cell lymphoma treated with immunochemotherapy
    Gonzalo Gutierrez-García
    Department of Hematology and Pathology, Hospital Clinic, University of Barcelona, Barcelona, Spain
    Blood 117:4836-43. 2011
    ..In conclusion, stratification based on immunostaining algorithms should be used with caution in guiding therapy, even in clinical trials...
  40. doi request reprint Current immunochemotherapy strategies in follicular lymphoma
    Eva Gine
    Department of Hematology, Hospital Clinic, Barcelona, Spain
    Adv Ther 27:704-13. 2010
    ..Finally, allogeneic transplantation should be reserved for a very select group of young high-risk patients in the setting of clinical trials...
  41. pmc High microvessel density determines a poor outcome in patients with diffuse large B-cell lymphoma treated with rituximab plus chemotherapy
    Teresa M Cardesa-Salzmann
    Hospital Clinic, University of Barcelona, Barcelona, Spain
    Haematologica 96:996-1001. 2011
    ..The purpose of this study is to assess the prognostic impact of histopathological microvessel density in two independent series of patients with diffuse large B-cell lymphoma treated with immunochemotherapy...
  42. ncbi request reprint Hematologic malignancies in patients with cryoglobulinemia: association with autoimmune and chronic viral diseases
    Olga Trejo
    Department of Autoimmune Diseases, Institut d Investigacions Biomediques August Pi i Sunyer IDIBAPS, Hospital Clinic, School of Medicine, University of Barcelona, Barcelona, Spain
    Semin Arthritis Rheum 33:19-28. 2003
    ....
  43. doi request reprint Primary cutaneous small/medium CD4+ T-cell lymphomas: a heterogeneous group of tumors with different clinicopathologic features and outcome
    Adriana Garcia-Herrera
    Hematopathology Section, Hospital Clinic, Villarroel 170, 08036 Barcelona, Spain
    J Clin Oncol 26:3364-71. 2008
    ..To define the clinical and pathologic characteristics of primary cutaneous small/medium CD4(+) T-cell lymphoma (PCSM-TCL) and identify parameters of prognostic significance...
  44. pmc Genetic imbalances in progressed B-cell chronic lymphocytic leukemia and transformed large-cell lymphoma (Richter's syndrome)
    Silvia Bea
    Hematopathology Section, Laboratory of Anatomic Pathology, Hospital Clinic, University of Barcelona, Spain
    Am J Pathol 161:957-68. 2002
    ..Genetic alterations detected by comparative genomic hybridization may also be of prognostic significance...
  45. ncbi request reprint Analysis of Aurora-A and hMPS1 mitotic kinases in mantle cell lymphoma
    Emma Camacho
    Department of Pathology, Hospital Clinic, Institut d Investigacions Biomediques August Pi i Sunyer, University of Barcelona, Barcelona, Spain
    Int J Cancer 118:357-63. 2006
    ..Although the Aurora-A P31I polymorphic variant is not directly involved in a genetic predisposition to these lymphomas, it may modulate the clinical presentation of these tumors...
  46. pmc SOX11 expression is highly specific for mantle cell lymphoma and identifies the cyclin D1-negative subtype
    Ana Mozos
    Hematopathology Section, Department of Pathology and Hematology, Hospital Clinic, Institut d Investigacions Biomediques August Pi i Sunyer IDIBAPS, University of Barcelona, Spain
    Haematologica 94:1555-62. 2009
    ..The aim of this study was to determine whether this gene is expressed in cyclin D1-negative mantle cell lymphoma and whether its detection may be useful to identify these tumors...
  47. doi request reprint Clinico-biological characteristics and outcome of hepatitis C virus-positive patients with diffuse large B-cell lymphoma treated with immunochemotherapy
    Ivan Dlouhy
    Department of Hematology, Hospital Clinic, Villarroel 170, 08036, Barcelona, Spain
    Ann Hematol . 2016
    ..The presence of HCV in DLBCL patients entails higher number of complications and early deaths; however, liver impairment and not the hepatitis viral status was the key feature in the outcome of the patients...
  48. pmc Detection of chromothripsis-like patterns with a custom array platform for chronic lymphocytic leukemia
    Itziar Salaverria
    Hematopathology Unit, Hospital Clínic Institut d Investigacions Biomèdiques August Pi i Sunyer IDIBAPS, Barcelona, Spain
    Genes Chromosomes Cancer 54:668-80. 2015
    ..This test may be used as a practical tool to stratify CLL patients for routine diagnostics or clinical trials...
  49. doi request reprint Recurrent mutations of NOTCH genes in follicular lymphoma identify a distinctive subset of tumours
    Kennosuke Karube
    Institut d Investigacions Biomediques August Pi i Sunyer, Hospital Clinic, Universitat de Barcelona, Spain
    J Pathol 234:423-30. 2014
    ..03). These results indicate that NOTCH mutations are uncommon in FL but may occur in a subset of cases with distinctive, characteristic, clinicopathological features...
  50. doi request reprint Different distribution of NOTCH1 mutations in chronic lymphocytic leukemia with isolated trisomy 12 or associated with other chromosomal alterations
    Cristina Lopez
    Hematopathology Unit, Pathology Department, Hospital Clinic, Institut d Investigacions Biomèdiques Agustí Pi i Sunyer IDIBAPS, University of Barcelona, Barcelona, Spain
    Genes Chromosomes Cancer 51:881-9. 2012
    ..001). These findings indicate that the distribution of NOTCH1 mutations in CLL with trisomy 12 is heterogeneous and that the presence of additional chromosomal abnormalities such as trisomy 18 could change the prognosis of these patients...
  51. ncbi request reprint Severe autoimmune cytopenias in treatment-naive hepatitis C virus infection: clinical description of 35 cases
    Manuel Ramos-Casals
    Department of Autoimmune Diseases, Institut d Investigacions Biomediques August Pi i Sunyer IDIBAPS, Hospital Clinic, School of Medicine, University of Barcelona, Spain
    Medicine (Baltimore) 82:87-96. 2003
    ..Hemolytic anemia and severe thrombocytopenia were the most frequent cytopenias observed. Most patients responded well to corticosteroids, although a higher rate of mortality was observed in those with liver cirrhosis...
  52. doi request reprint Genomic profiling reveals different genetic aberrations in systemic ALK-positive and ALK-negative anaplastic large cell lymphomas
    Itziar Salaverria
    Haematopathology Section, Department of Pathology, Hospital Clinic, Istitute d Inverstigacions Biomèdiques August Pi i Sunyer IDIBAPS, University of Barcelona, Barcelona, Spain
    Br J Haematol 140:516-26. 2008
    ..However no specific chromosomal alterations were associated with survival. In conclusion, ALK-positive and negative ALCL have different secondary genomic aberrations, suggesting they correspond to different genetic entities...
  53. pmc Specific secondary genetic alterations in mantle cell lymphoma provide prognostic information independent of the gene expression-based proliferation signature
    Itziar Salaverria
    Department of Pathology and Hematology, Hospital Clinic, University of Barcelona, Barcelona, Spain
    J Clin Oncol 25:1216-22. 2007
    ....
  54. ncbi request reprint International and Italian prognostic indices in follicular lymphoma
    Granada Perea
    Department of Hematology, Hospital de la Santa Creu i Sant Pau, Barcelona, Spain
    Haematologica 88:700-4. 2003
    ..The Italian Lymphoma Intergroup (ILI) created a new prognostic index specific for FL. The aim of this study was to compare which of these two indices is more useful when applied to a large group of FL patients...
  55. doi request reprint HHV8-related lymphoid proliferations: a broad spectrum of lesions from reactive lymphoid hyperplasia to overt lymphoma
    Blanca Gonzalez-Farre
    Department of Pathology, Hospital Clinic, Institut d Investigacions Biomediques August Pi i Sunyer IDIBAPS, University of Barcelona, Barcelona, Spain
    Mod Pathol . 2017
    ..Modern Pathology advance online publication, 13 January 2017; doi:10.1038/modpathol.2016.233...
  56. ncbi request reprint MicroRNA expression profiling in classic Hodgkin lymphoma
    Alfons Navarro
    Department of Human Anatomy and Embryology, Laboratory of Molecular Oncology, School of Medicine, Barcelona University, Barcelona, Spain
    Blood 111:2825-32. 2008
    ..miR-96, miR-128a, and miR-128b were selectively down-regulated in cHL with EBV. Our findings suggest that miRNAs play an important role in the biology of cHL and may be useful in developing therapies targeting miRNAs...
  57. doi request reprint Interim FDG PET/CT as a prognostic factor in diffuse large B-cell lymphoma
    Silvia Fuertes
    Nuclear Medicine Department, Clinic University Hospital, Barcelona, Spain
    Eur J Nucl Med Mol Imaging 40:496-504. 2013
    ....
  58. pmc CCND2 rearrangements are the most frequent genetic events in cyclin D1(-) mantle cell lymphoma
    Itziar Salaverria
    Department of Pathology, Hematopathology Unit, Hospital Clinic, Institut d Investigacions Biomediques August Pi i Sunyer, University of Barcelona, Barcelona, Spain
    Blood 121:1394-402. 2013
    ....
  59. pmc Molecular subsets of mantle cell lymphoma defined by the IGHV mutational status and SOX11 expression have distinct biologic and clinical features
    Alba Navarro
    Pathology and Hematology Departments, Hospital Clinic, University of Barcelona, Institute of Biomedical Research August Pi i Sunyer IDIBAPS, Spain
    Cancer Res 72:5307-16. 2012
    ..In conclusion, these observations suggest the idea that MCL with mutated IGHV, SOX11-negativity, and nonnodal presentation correspond to a subtype of the disease with more indolent behavior...
  60. ncbi request reprint Autologous stem cell transplantation for patients with active Hodgkin's lymphoma: long-term outcome of 61 patients from a single institution
    Carmen Martinez
    Department of Hematology, Institute of Hematology and Oncology, Institut d Investigacions Biomediques August Pi i Sunyer IDIBAPS, Hospital Clinic, University of Barcelona, Barcelona, Spain
    Leuk Lymphoma 48:1968-75. 2007
    ..Although long-term outcome of patients with active HL at the time of ASCT is poor due to a high TRM and a low CR after transplantation, a subgroup of patients with no adverse prognostic factors at ASCT gain benefit from this treatment...
  61. doi request reprint Initial features and outcome of cutaneous and non-cutaneous primary extranodal follicular lymphoma
    Carlos Fernández de Larrea
    Departments of Haematology Pathology Dermatology, Hospital Clinic, Institut d Investigacions Biomediques August Pi i Sunyer IDIBAPS, Barcelona, Spain
    Br J Haematol 153:334-40. 2011
    ..In conclusion, extranodal FLs, particularly cutaneous, have particular clinico-biological features, which differentiate them from nodal cases. Nevertheless, primary site of the disease is not the main issue to predict outcome...
  62. doi request reprint High numbers of tumor-infiltrating programmed cell death 1-positive regulatory lymphocytes are associated with improved overall survival in follicular lymphoma
    Joaquim Carreras
    Hematopathology Section, Department of Pathology, Hospital Clinic, Institut d Investigacions Biomèdiques August Pi Sunyer, University of Barcelona, Spain
    J Clin Oncol 27:1470-6. 2009
    ..The aim of this study was to determine the impact of programmed cell death 1 (PD-1) -positive inhibitory immunoregulatory lymphoid cells in the clinicobiologic features and outcome of patients with FL...
  63. doi request reprint Plasmablastic transformation of low-grade B-cell lymphomas: report on 6 cases
    Daniel Martinez
    Department of Hematopathology and Hematology, Hospital Clinic, Institut d Investigacions Biomediques August Pi i Sunyer IDIBAPS, University of Barcelona, Barcelona, Spain
    Am J Surg Pathol 37:272-81. 2013
    ..These transformed tumors are clinically, histologically, and phenotypically similar to primary plasmablastic lymphomas, but they are not associated with immunodeficiency and rarely have Epstein-Barr virus infection or MYC alterations...
  64. pmc Activation of the endoplasmic reticulum stress-associated transcription factor x box-binding protein-1 occurs in a subset of normal germinal-center B cells and in aggressive B-cell lymphomas with prognostic implications
    Olga Balague
    Hematopathology Section, Hospital Clinic, Villarroel 170, 08036 Barcelona, Barcelona, Spain
    Am J Pathol 174:2337-46. 2009
    ..These findings suggest that Xbp-1 activation may play a role in the pathogenesis of aggressive B-cell lymphomas...
  65. doi request reprint Clinical practice guidelines for diagnosis, treatment, and follow-up of patients with mantle cell lymphoma. Recommendations from the GEL/TAMO Spanish Cooperative Group
    Dolores Caballero
    Department of Hematology, Hospital Clinico Universitario, Instituto de Investigación Biomédica de Salamanca IBSAL, Paseo de San Vicente 58, 37007, Salamanca, Spain
    Ann Hematol 92:1151-79. 2013
    ..On the basis of the available evidence, a series of recommendations have been issued with the intention of providing guidance to clinicians on the diagnosis, treatment, and monitoring of patients with MCL. ..
  66. doi request reprint MicroRNA expression, chromosomal alterations, and immunoglobulin variable heavy chain hypermutations in Mantle cell lymphomas
    Alba Navarro
    Department of Pathology Hematopathology Unit, Hospital Clinic, Institut d Investigacions Biomediques August Pi i Sunyer, University of Barcelona
    Cancer Res 69:7071-8. 2009
    ..In conclusion, the miR expression pattern of MCL is deregulated in comparison with normal lymphoid cells and distinguishes two subgroups of tumors with different biological features...
  67. ncbi request reprint Low p27 expression predicts biochemical relapse after radical prostatectomy in patients with clinically localised prostate cancer
    Maria J Ribal
    Departments of Urology and Kidney Transplant, Hospital Clinic, Institut d Investigacio Biomedica August Pi i Sunyer IDIBAPS, Barcelona, Spain
    Anticancer Res 23:5101-6. 2003
    ..To assess the prognostic value of p27 protein expression in clinically localised prostate cancer with respect to biochemical recurrence after radical prostatectomy...
  68. pmc CD69 expression potentially predicts response to bendamustine and its modulation by ibrutinib or idelalisib enhances cytotoxic effect in chronic lymphocytic leukemia
    Arnau Montraveta
    Institut d Investigacions Biomediques August Pi i Sunyer IDIBAPS, Barcelona, Spain
    Oncotarget 7:5507-20. 2016
    ....
  69. pmc Survival analysis in hematologic malignancies: recommendations for clinicians
    Julio Delgado
    Department of Hematology, Hospital Clinic, IDIBAPS, Barcelona
    Haematologica 99:1410-20. 2014
    ..We also provide practical advice on how to check the proportional hazards assumption and briefly review the role of relative survival and multiple imputation. ..
  70. doi request reprint Adult haemophagocytic syndrome
    Manuel Ramos-Casals
    Josep Font Laboratory of Autoimmune Diseases CELLEX, Department of Autoimmune Diseases, Institut Clinic de Medicina i Dermatologia, Hospital Clinic, Institut d Investigacions Biomediques August Pi i Sunyer IDIBAPS, University of Barcelona, Barcelona, Spain
    Lancet 383:1503-16. 2014
    ..Insufficient knowledge of these syndromes could contribute to poor prognosis. Early diagnosis is essential to initiate appropriate treatment and improve the quality of life and survival of patients with this challenging disorder...
  71. ncbi request reprint [The value of positron emission tomography/computed tomography (PET/CT) in the staging of diffuse large B-cell lymphoma]
    Silvia Fuertes
    Servicio de Medicina Nuclear, Hospital Clinic de Barcelona, Villaroel 170, Barcelona, Spain
    Med Clin (Barc) 129:688-93. 2007
    ....
  72. ncbi request reprint Triple association between hepatitis C virus infection, systemic autoimmune diseases, and B cell lymphoma
    Manuel Ramos-Casals
    Departments of Autoimmune Diseases and Hematology, Institut d Investigacions Biomediques August Pi i Sunyer IDIBAPS, Hospital Clinic, University of Barcelona, Barcelona, Spain
    J Rheumatol 31:495-9. 2004
    ..To analyze the clinical characteristics of patients from a Department of Autoimmune Diseases presenting chronic hepatitis C virus (HCV) infection, systemic autoimmune disease, and B cell lymphoma...
  73. ncbi request reprint Activation of mitochondrial apoptotic pathway in mantle cell lymphoma: high sensitivity to mitoxantrone in cases with functional DNA-damage response genes
    Ana Ferrer
    Department of Hematology, Hematopathology Unit, Hospital Clinic, Institut d Investigacions Biomediques August Pi i Sunyer, University of Barcelona, Spain
    Oncogene 23:8941-9. 2004
    ..These results support that mitoxantrone can be effective in the treatment of MCL but that this activity requires the integrity of functional DNA-damage response genes...
  74. doi request reprint Epigenomic analysis detects widespread gene-body DNA hypomethylation in chronic lymphocytic leukemia
    Marta Kulis
    Unidad de Hematopatología, Servicio de Anatomia Patologica, Hospital Clinic, Universitat de Barcelona, Institut d Investigacions Biomediques August Pi i Sunyer, Spain
    Nat Genet 44:1236-42. 2012
    ..We propose an epigenomic scenario in which differential methylation in the gene body may have functional and clinical implications in leukemogenesis...
  75. doi request reprint Primary bone marrow lymphoma: an uncommon extranodal presentation of aggressive non-hodgkin lymphomas
    Antonio Martinez
    Hematopathology and Hematology Department, Hospital Clinic, IDIBAPS, University of Barcelona, Barcelona, Spain
    Am J Surg Pathol 36:296-304. 2012
    ..8 years. In conclusion, PBML is a very uncommon lymphoma with particular clinical features and heterogenous histology. Its recognition is important to establish accurate diagnosis and adequate therapy...
  76. ncbi request reprint Characterization of B cell lymphoma in patients with Sjögren's syndrome and hepatitis C virus infection
    Manuel Ramos-Casals
    Hospital Clinic, Institut d Investigacions Biomediques August Pi i Sunyer, School of Medicine, University of Barcelona, Barcelona, Spain
    Arthritis Rheum 57:161-70. 2007
    ..To characterize the clinical and immunologic patterns of expression, response to therapy, and outcome of patients with Sjögren's syndrome (SS) and associated hepatitis C virus (HCV) infection who developed B cell lymphoma...