Elena Delgado

Summary

Affiliation: Instituto de Salud Carlos III
Country: Spain

Publications

  1. ncbi request reprint Near full-length genome characterization of an HIV type 1 CRF05_DF virus from Spain
    Gema Casado
    National Microbiology Center, Carlos III Institute of Health, Ctra Majadahonda Pozuelo, Km 2, 28220 Majadahonda, Madrid, Spain
    AIDS Res Hum Retroviruses 19:719-25. 2003
  2. pmc Oligonucleotide ligation assay for detection of mutations associated with reverse transcriptase and protease inhibitor resistance in non-B subtypes and recombinant forms of human immunodeficiency virus type 1
    Yolanda Vega
    Area de Patogenia Viral, Centro Nacional de Microbiologia, Instituto de Salud Carlos III, 28220 Majadahonda, Madrid, Spain
    J Clin Microbiol 43:5301-4. 2005
  3. doi request reprint High prevalence of unique recombinant forms of HIV-1 in Ghana: molecular epidemiology from an antiretroviral resistance study
    Elena Delgado
    Viral Pathogenesis Department, Centro Nacional de Microbiologia, Instituto de Salud Carlos III, Majadahonda, Madrid, Spain
    J Acquir Immune Defic Syndr 48:599-606. 2008
  4. doi request reprint Identification of a new HIV type 1 circulating BF intersubtype recombinant form (CRF47_BF) in Spain
    Aurora Fernández-García
    Centro Nacional de Microbiologia, Instituto de Salud Carlos III, Majadahonda, Madrid, Spain
    AIDS Res Hum Retroviruses 26:827-32. 2010
  5. doi request reprint Molecular epidemiology of HIV-1 in St Petersburg, Russia: predominance of subtype A, former Soviet Union variant, and identification of intrasubtype subclusters
    Michael M Thomson
    Centro Nacional de Microbiologia, Instituto de Salud Carlos III, 28220 Majadahonda, Madrid, Spain
    J Acquir Immune Defic Syndr 51:332-9. 2009
  6. ncbi request reprint Isolation and biological characterization of HIV-1 BG intersubtype recombinants and other genetic forms circulating in Galicia, Spain
    Lucia Perez-Alvarez
    Area de Patogenia Viral, Centro Nacional de Microbiologia, Instituto de Salud Carlos III, Majadahonda, Madrid, Spain
    J Med Virol 78:1520-8. 2006
  7. doi request reprint HIV type 1 intersubtype recombinants during the evolution of a dual infection with subtypes B and G
    Mercedes Muñoz-Nieto
    Area de Patogenia Viral, Centro Nacional de Microbiologia, Instituto de Salud Carlos III, 28220 Majadahonda, Madrid, Spain
    AIDS Res Hum Retroviruses 24:337-43. 2008
  8. ncbi request reprint The analysis of near full-length genome sequences of human immunodeficiency virus type 1 BF intersubtype recombinant viruses from Chile, Venezuela and Spain reveals their relationship to diverse lineages of recombinant viruses related to CRF12_BF
    Maria Sierra
    Centro Nacional de Biologia Fundamental, Instituto de Salud Carlos III, Ctra, Majadahonda Pozuelo, Km 2, 28220 Majadahonda, Madrid, Spain
    Infect Genet Evol 5:209-17. 2005
  9. ncbi request reprint Analysis of discrepancies in the interpretation of antiretroviral drug resistance results in HIV-1 infected patients of Basque Country, Spain
    MERCEDES MUNOZ
    Viral Pathogenesis Department, Centro Nacional de Microbiologia, Instituto de Salud Carlos III, Carretera de Majadahonda a Pozuelo, 28220 Majadahonda, Madrid, Spain
    J Clin Virol 33:224-9. 2005
  10. doi request reprint Identification of a new HIV type 1 BF intersubtype circulating recombinant form (CRF44_BF) in Chile
    Elena Delgado
    Unit of Biology and Variability of HIV, Spanish National Center of Microbiology, Instituto de Salud Carlos III, Majadahonda, Madrid, Spain
    AIDS Res Hum Retroviruses 26:821-6. 2010

Collaborators

  • Michael M Thomson
  • Maria Teresa Cuevas
  • Celia Miralles
  • Saladin Osmanov
  • Marcos Pérez-Losada
  • R Cisterna
  • Kwasi Torpey
  • G Cilla
  • Michael S Seaman
  • R Najera
  • Lucia Perez-Alvarez
  • Yolanda Vega
  • Aurora Fernández-García
  • Cristina Carrera
  • Antonio Ocampo
  • Gerardo Contreras
  • Valentina García
  • Sonia Pérez-Castro
  • Maria Sierra
  • Gema Casado
  • MERCEDES MUNOZ
  • Rocio Carmona
  • Leandro Medrano
  • Vanessa Montero
  • Francisco Díez-Fuertes
  • Maritza Ríos
  • Lissette Pérez
  • Ana Revilla
  • Milagros Pinilla
  • Mercedes Muñoz-Nieto
  • Elena Vazquez de Parga
  • J A Patiño-Galindo
  • Monica Sanchez
  • María José López-Álvarez
  • Elena Vázquez de Parga
  • María J Lezaun
  • Ana Mariño
  • Patricia Ordóñez
  • Anna Vinogradova
  • Aza Rakhmanova
  • María González-Galeano
  • Rafael Ojea de Castro
  • María Jesús Lezaun
  • Elena Vázquez-de Parga
  • Zoila González
  • Carlos Aragonés
  • Jorge Perez
  • Carmen Hinojosa
  • Angel Zaballos
  • Jose A Iribarren
  • Jorge de la Barrera
  • Hortensia Alvarez
  • Isabel López-Miragaya
  • Elena García-Bodas
  • Isabel Cuesta
  • Leyre López-Soria
  • Maria L Villahermosa
  • F Gonzalez-Candelas
  • Ana Maria Sanchez
  • Teresa Cuevas
  • Sara Calleja
  • Carmen Ramos
  • Ana M Sánchez-García
  • Beatriz García-Riart
  • Elena Bereciartua
  • Ricardo Fernández-Rodríguez
  • Ricardo Rodríguez-Real
  • Paloma Nebreda
  • Eduard Karamov
  • Justin Dalrymple
  • Santiago Prieto
  • David C Montefiori
  • Elizabeth C Christian
  • Juan M Santamaría
  • Raul Rodriguez
  • Ana M Sanchez
  • Jose Antonio Iribarren
  • Matilde Trigo
  • Verónica Yung
  • Jorge Fernandez
  • Paula Gálvez
  • Lucía Pérez Alvarez
  • María J Bleda
  • Javier Colomina
  • Raúl Ojea de Castro
  • Jesús Corral
  • Gloria Echevarría
  • María José López de Goicoetxea
  • María Dolores Suárez
  • José Antonio Taboada

Detail Information

Publications34

  1. ncbi request reprint Near full-length genome characterization of an HIV type 1 CRF05_DF virus from Spain
    Gema Casado
    National Microbiology Center, Carlos III Institute of Health, Ctra Majadahonda Pozuelo, Km 2, 28220 Majadahonda, Madrid, Spain
    AIDS Res Hum Retroviruses 19:719-25. 2003
    ..Three other reported DF recombinant viruses, including the fully sequenced VI1310, exhibit incomplete homology to VI961 and X492...
  2. pmc Oligonucleotide ligation assay for detection of mutations associated with reverse transcriptase and protease inhibitor resistance in non-B subtypes and recombinant forms of human immunodeficiency virus type 1
    Yolanda Vega
    Area de Patogenia Viral, Centro Nacional de Microbiologia, Instituto de Salud Carlos III, 28220 Majadahonda, Madrid, Spain
    J Clin Microbiol 43:5301-4. 2005
    ..This assay has been modified and developed for non-B subtypes and recombinant strains and has been evaluated with sequencing, resulting in a more sensitive assay than sequencing for non-B subtypes...
  3. doi request reprint High prevalence of unique recombinant forms of HIV-1 in Ghana: molecular epidemiology from an antiretroviral resistance study
    Elena Delgado
    Viral Pathogenesis Department, Centro Nacional de Microbiologia, Instituto de Salud Carlos III, Majadahonda, Madrid, Spain
    J Acquir Immune Defic Syndr 48:599-606. 2008
    ..In Ghana, programs to expand antiretroviral access are being implemented. In this context, the dynamic genetic evolution of HIV-1 requires continuous surveillance, particularly when diverse genetic forms co-circulate...
  4. doi request reprint Identification of a new HIV type 1 circulating BF intersubtype recombinant form (CRF47_BF) in Spain
    Aurora Fernández-García
    Centro Nacional de Microbiologia, Instituto de Salud Carlos III, Majadahonda, Madrid, Spain
    AIDS Res Hum Retroviruses 26:827-32. 2010
    ..Recent dates of HIV-1 diagnoses and short genetic distances suggest a recent origin of this CRF. This is the tenth reported CRF_BF, the first apparently having originated outside of South America...
  5. doi request reprint Molecular epidemiology of HIV-1 in St Petersburg, Russia: predominance of subtype A, former Soviet Union variant, and identification of intrasubtype subclusters
    Michael M Thomson
    Centro Nacional de Microbiologia, Instituto de Salud Carlos III, 28220 Majadahonda, Madrid, Spain
    J Acquir Immune Defic Syndr 51:332-9. 2009
    ..To examine HIV-1 genetic diversity in St. Petersburg...
  6. ncbi request reprint Isolation and biological characterization of HIV-1 BG intersubtype recombinants and other genetic forms circulating in Galicia, Spain
    Lucia Perez-Alvarez
    Area de Patogenia Viral, Centro Nacional de Microbiologia, Instituto de Salud Carlos III, Majadahonda, Madrid, Spain
    J Med Virol 78:1520-8. 2006
    ..These data contrast with the usual progression in B subtype infections, in which SI/X4 viruses rarely predominate in the early years of HIV-1 infection...
  7. doi request reprint HIV type 1 intersubtype recombinants during the evolution of a dual infection with subtypes B and G
    Mercedes Muñoz-Nieto
    Area de Patogenia Viral, Centro Nacional de Microbiologia, Instituto de Salud Carlos III, 28220 Majadahonda, Madrid, Spain
    AIDS Res Hum Retroviruses 24:337-43. 2008
    ..The env sequence from all primary isolates harbored a unique insert of subtype B. Specific primers for the V3 loop identified fluctuating subtype B and/or subtype G sequences either from plasma RNA or PBMC DNA...
  8. ncbi request reprint The analysis of near full-length genome sequences of human immunodeficiency virus type 1 BF intersubtype recombinant viruses from Chile, Venezuela and Spain reveals their relationship to diverse lineages of recombinant viruses related to CRF12_BF
    Maria Sierra
    Centro Nacional de Biologia Fundamental, Instituto de Salud Carlos III, Ctra, Majadahonda Pozuelo, Km 2, 28220 Majadahonda, Madrid, Spain
    Infect Genet Evol 5:209-17. 2005
    ..Based on these results, a model of generation of HIV-1 BF recombinants of Argentinean ancestry by successive rounds of recombination along diverse lineages deriving from a common BF recombinant ancestor related to CRF12_BF is proposed...
  9. ncbi request reprint Analysis of discrepancies in the interpretation of antiretroviral drug resistance results in HIV-1 infected patients of Basque Country, Spain
    MERCEDES MUNOZ
    Viral Pathogenesis Department, Centro Nacional de Microbiologia, Instituto de Salud Carlos III, Carretera de Majadahonda a Pozuelo, 28220 Majadahonda, Madrid, Spain
    J Clin Virol 33:224-9. 2005
    ..However, some levels of discordance among them has been described...
  10. doi request reprint Identification of a new HIV type 1 BF intersubtype circulating recombinant form (CRF44_BF) in Chile
    Elena Delgado
    Unit of Biology and Variability of HIV, Spanish National Center of Microbiology, Instituto de Salud Carlos III, Majadahonda, Madrid, Spain
    AIDS Res Hum Retroviruses 26:821-6. 2010
    ..Coincident breakpoints and phylogenetic clustering of the newly identified CRF44_BF with CRF12_BF, CRF17_BF, and CRF38_BF support a common origin of different CRF_BFs identified in Argentina, Uruguay, and Chile...
  11. ncbi request reprint High incidence of non-B and recombinant HIV-1 strains in newly diagnosed patients in Galicia, Spain: study of genotypic resistance
    Lucia Perez-Alvarez
    Area de Patogenia Viral, Centro Nacional de Microbiologia, Instituto de Salud Carlos III, Madrid, Spain
    Antivir Ther 8:355-60. 2003
    ..001). This study reports a high incidence (22.3%) of newly diagnosed patients infected by different non-B and recombinant HIV-1 strains, in a geographical area of Spain, showing also a high frequency of polymorphisms in RT and PR genes...
  12. pmc The analysis of near full-length genome sequences of HIV type 1 subtype A viruses from Russia supports the monophyly of major intrasubtype clusters
    Aurora Fernández-García
    Centro Nacional de Microbiologia, Instituto de Salud Carlos III, Majadahonda, Madrid, Spain
    AIDS Res Hum Retroviruses 28:1340-3. 2012
    ..Similarly, the four A(SP1) genomes group in a monophyletic cluster. These results therefore show that the monophyly of V77I(PR) and A(SP1) A(FSU) clusters is supported in near complete genomes...
  13. doi request reprint HIV-1 transmission cluster with T215D revertant mutation among newly diagnosed patients from the Basque Country, Spain
    Maria Teresa Cuevas
    Viral Pathogenesis Department, Centro Nacional de Microbiologia, Instituto de Salud Carlos III, Majadahonda, Madrid, Spain
    J Acquir Immune Defic Syndr 51:99-103. 2009
    ..To determine the introduction of HIV-1 genetic forms and to examine transmission clusters and resistance to antiretroviral inhibitors among newly diagnosed patients from the Basque Country, Spain, during 2004-2007...
  14. ncbi request reprint New insights into the origin of the HIV type 1 subtype A epidemic in former Soviet Union's countries derived from sequence analyses of preepidemically transmitted viruses
    Michael M Thomson
    Centro Nacional de Microbiologia, Instituto de Salud Carlos III, Majadahonda, Madrid, Spain
    AIDS Res Hum Retroviruses 23:1599-604. 2007
    ..The results indicate that the FSU IDU-A variant derives from a strain that initially propagated heterosexually in Ukraine and originated in central Africa...
  15. doi request reprint Improvement of HIV-1 coreceptor tropism prediction by employing selected nucleotide positions of the env gene in a Bayesian network classifier
    Francisco Díez-Fuertes
    HIV Biology and Variability Unit, Centro Nacional de Microbiologia, Instituto de Salud Carlos III, Majadahonda, Madrid, Spain
    J Antimicrob Chemother 68:1471-85. 2013
    ....
  16. ncbi request reprint Primary resistance mutations to fusion inhibitors and polymorphisms in gp41 sequences of HIV-1 non-B subtypes and recombinants
    Maria L Villahermosa
    Instituto de Salud Carlos III, Patogenia Viral, Majadahonda, Madrid, Spain
    AIDS 17:1083-6. 2003
    ..V194I and V318A, not described in the G subtype, were detected in the G region of BG recombinants and in G subtype viruses that also show the rare mutations T115L, M118V and K90R...
  17. ncbi request reprint High HIV-1 genetic diversity in Cuba
    Maria Teresa Cuevas
    Instituto de Salud Carlos III, Madrid, Spain
    AIDS 16:1643-53. 2002
    ..HIV-1 subtype B is largely predominant in the Caribbean, although other subtypes have been recently identified in Cuba...
  18. pmc Identification of an HIV-1 BG Intersubtype Recombinant Form (CRF73_BG), Partially Related to CRF14_BG, Which Is Circulating in Portugal and Spain
    Aurora Fernández-García
    Centro Nacional de Microbiologia, Instituto de Salud Carlos III, Majadahonda, Madrid, Spain
    PLoS ONE 11:e0148549. 2016
    ..The fact that an HIV-1 recombinant virus characterized ten years ago as a URF has been shown to represent a CRF suggests that the number of HIV-1 CRFs may be much greater than currently known. ..
  19. pmc Epidemiological Surveillance of HIV-1 Transmitted Drug Resistance in Spain in 2004-2012: Relevance of Transmission Clusters in the Propagation of Resistance Mutations
    Yolanda Vega
    Unidad de Biología y Variabilidad de VIH, Centro Nacional de Microbiologia, Instituto de Salud Carlos III, Majadahonda, Madrid, Spain
    PLoS ONE 10:e0125699. 2015
    ..The knowledge of the populations involved in TC would facilitate the design of prevention programs and public health interventions. ..
  20. pmc Identification of new and unusual rev and nef transcripts expressed by an HIV type 1 primary isolate
    Yolanda Vega
    Centro Nacional de Microbiologia, Instituto de Salud Carlos III, Majadahonda, Madrid, Spain
    AIDS Res Hum Retroviruses 29:1075-8. 2013
    ..3.7 were identified. The identification of several unusual and unreported spliced transcripts in an HIV-1 primary isolate suggests a greater diversity of splice site usage in HIV-1 than previously appreciated...
  21. ncbi request reprint Identification of a newly characterized HIV-1 BG intersubtype circulating recombinant form in Galicia, Spain, which exhibits a pseudotype-like virion structure
    Elena Delgado
    Instituto de Salud Carlos III, Ctra Majadahonda Pozuelo, Km 2, 28220 Majadahonda, Madrid, Spain
    J Acquir Immune Defic Syndr 29:536-43. 2002
    ..These results allow us to define a new HIV-1 circulating recombinant form (CRF14_BG), the first reported to originate in Western Europe...
  22. pmc Identification of new splice sites used for generation of rev transcripts in human immunodeficiency virus type 1 subtype C primary isolates
    Elena Delgado
    Centro Nacional de Microbiologia, Instituto de Salud Carlos III, Majadahonda, Madrid, Spain
    PLoS ONE 7:e30574. 2012
    ..Usage of the newly identified splice sites is consistent with sequence features commonly found in subtype C viruses. These results show that splice site usage may differ between HIV-1 subtypes...
  23. doi request reprint Evaluation of genotypic tropism prediction tests compared with in vitro co-receptor usage in HIV-1 primary isolates of diverse subtypes
    Elena Delgado
    HIV Biology and Variability Department, Centro Nacional de Microbiologia, Instituto de Salud Carlos III, Majadahonda, Madrid, Spain
    J Antimicrob Chemother 67:25-31. 2012
    ....
  24. doi request reprint Transmission dynamics of HIV-1 subtype B in the Basque Country, Spain
    J A Patiño-Galindo
    Joint Research Unit Infection and Public Health FISABIO Universitat de Valencia, Spain CIBER in Epidemiology and Public Health, Madrid, Spain
    Infect Genet Evol 40:91-7. 2016
    ..Public health control measures should be reinforced to prevent the further expansion of transmission clusters and resistant mutations occurring within them. ..
  25. doi request reprint Predominance of CXCR4 tropism in HIV-1 CRF14_BG strains from newly diagnosed infections
    Lucia Perez-Alvarez
    HIV Biology and Variability Unit, Centro Nacional de Microbiologia, Instituto de Salud Carlos III, Majadahonda, Madrid, Spain
    J Antimicrob Chemother 69:246-53. 2014
    ..In this study, we compared the frequency of X4 tropism in individuals infected with HIV-1 CRF14_BG viruses, which have a V3 loop of subtype B, with a control group of individuals infected with subtype B viruses...
  26. doi request reprint Construction and phenotypic characterization of HIV type 1 functional envelope clones of subtypes G and F
    Ana Revilla
    Centro Nacional de Microbiologia, Instituto de Salud Carlos III, Majadahonda, Madrid, Spain
    AIDS Res Hum Retroviruses 27:889-901. 2011
    ....
  27. pmc Sequence Analysis of In Vivo-Expressed HIV-1 Spliced RNAs Reveals the Usage of New and Unusual Splice Sites by Viruses of Different Subtypes
    Yolanda Vega
    HIV Biology and Variability Unit, Centro Nacional de Microbiologia, Instituto de Salud Carlos III Majadahonda, Madrid, Spain
    PLoS ONE 11:e0158525. 2016
    ..The fact that four of five newly identified splice sites or variants of splice sites were detected in non-subtype B viruses allows anticipating an even greater diversity of HIV-1 splice site usage than currently known. ..
  28. pmc Phylogeny and Phylogeography of a Recent HIV-1 Subtype F Outbreak among Men Who Have Sex with Men in Spain Deriving from a Cluster with a Wide Geographic Circulation in Western Europe
    Elena Delgado
    HIV Biology and Variability Unit, Centro Nacional de Microbiologia, Instituto de Salud Carlos III, Majadahonda, Madrid, Spain
    PLoS ONE 10:e0143325. 2015
    ....
  29. ncbi request reprint Genetic recombination and its role in the development of the HIV-1 pandemic
    Rafael Najera
    Department of Viral Patogénesis, Instituto de Salud Carlos III, Majadahonda, Madrid, Spain
    AIDS 16:S3-16. 2002
  30. ncbi request reprint Diversity of mosaic structures and common ancestry of human immunodeficiency virus type 1 BF intersubtype recombinant viruses from Argentina revealed by analysis of near full-length genome sequences
    Michael M Thomson
    Department of Viral Pathogenesis, Instituto de Salud Carlos III, Ctra Majadahonda Pozuelo, Km 2, 28220 Majadahonda, Madrid, Spain
    J Gen Virol 83:107-19. 2002
    ....
  31. ncbi request reprint Antiretroviral drug resistance and phylogenetic diversity of HIV-1 in Chile
    Maritza Ríos
    Centro Nacional de Referencia de VIH SIDA, Instituto de Salud Publica de Chile, Santiago, Chile
    J Med Virol 79:647-56. 2007
    ..Additionally, phylogenetic analysis of the PR-RT coding sequences reveals the presence of BF intersubtype recombinants...
  32. ncbi request reprint Genotypic resistance to antiretroviral drugs in patients infected with several HIV type 1 genetic forms in Cuba
    Lissette Pérez
    Instituto de Medicina Tropical Pedro Kouri, La Habana, Cuba
    AIDS Res Hum Retroviruses 23:407-14. 2007
    ..The presence of transmitted resistance mutations supports the study of resistance at baseline of treatment...
  33. ncbi request reprint HIV Type 1 molecular epidemiology in cuba: high genetic diversity, frequent mosaicism, and recent expansion of BG intersubtype recombinant forms
    Lissette Pérez
    Instituto de Medicina Tropical Pedro Kouri, La Habana, Cuba
    AIDS Res Hum Retroviruses 22:724-33. 2006
    ..This study confirms the high HIV-1 diversity and frequent recombination in Cuba and reveals the recent expansion of diverse related BG recombinant forms in this country...
  34. ncbi request reprint Biological characteristics of newly described HIV-1 BG recombinants in Spanish individuals
    Lucia Perez-Alvarez
    AIDS 16:669-72. 2002