Joan Seoane

Summary

Affiliation: Hospital Universitari Vall d'Hebron
Country: Spain

Publications

  1. ncbi request reprint Integration of Smad and forkhead pathways in the control of neuroepithelial and glioblastoma cell proliferation
    Joan Seoane
    Cancer Biology and Genetics Program and Howard Hughes Medical Institute, Memorial Sloan Kettering Cancer Center, 1275 York Avenue, 1300 York Avenue, New York, NY 1002, USA
    Cell 117:211-23. 2004
  2. ncbi request reprint p21(WAF1/CIP1) at the switch between the anti-oncogenic and oncogenic faces of TGFbeta
    Joan Seoane
    Laboratory of Oncology Research, Medical Oncology Service, Vall d Hebron University Hospital, Psg Vall d Hebron 119 129, 08035 Barcelona, Spain
    Cancer Biol Ther 3:226-7. 2004
  3. ncbi request reprint Myc suppression of the p21(Cip1) Cdk inhibitor influences the outcome of the p53 response to DNA damage
    Joan Seoane
    Cell Biology Program and Howard Hughes Medical Institute, Memorial Sloan Kettering Cancer Center, New York, NY 10021, USA
    Nature 419:729-34. 2002
  4. ncbi request reprint Escaping from the TGFbeta anti-proliferative control
    Joan Seoane
    Institucio Catalana de Recerca i Estudis Avancats ICREA, Medical Oncology Program Vall d Hebron University Hospital Research Institute, Barcelona, Spain
    Carcinogenesis 27:2148-56. 2006
  5. ncbi request reprint High TGFbeta-Smad activity confers poor prognosis in glioma patients and promotes cell proliferation depending on the methylation of the PDGF-B gene
    Alejandra Bruna
    Medical Oncology Program, Vall d Hebron University Hospital Research Institute, 08035 Barcelona, Spain
    Cancer Cell 11:147-60. 2007
  6. ncbi request reprint Opposite Smad and chicken ovalbumin upstream promoter transcription factor inputs in the regulation of the collagen VII gene promoter by transforming growth factor-beta
    María Julia Calonge
    Cell Biology Program and Howard Hughes Medical Institute, Memorial Sloan Kettering Cancer Center, New York, New York 10021, USA
    J Biol Chem 279:23759-65. 2004
  7. ncbi request reprint Smad transcription factors
    Joan Massague
    Cancer Biology and Genetics Program, Howard Hughes Medical Institute, Memorial Sloan Kettering Cancer Center, New York, New York 10021, USA
    Genes Dev 19:2783-810. 2005
  8. pmc A FoxO-Smad synexpression group in human keratinocytes
    Roger R Gomis
    Cancer Biology and Genetics Program, Howard Hughes Medical Institute, and Bioinformatics Core Facility, Memorial Sloan Kettering Cancer Center, New York, NY 10021, USA
    Proc Natl Acad Sci U S A 103:12747-52. 2006
  9. ncbi request reprint TGF-beta signalling-related markers in cancer patients with bone metastasis
    Jose Baselga
    Vall d Hebron University Hospital, Barcelona, Spain
    Biomarkers 13:217-36. 2008

Collaborators

Detail Information

Publications9

  1. ncbi request reprint Integration of Smad and forkhead pathways in the control of neuroepithelial and glioblastoma cell proliferation
    Joan Seoane
    Cancer Biology and Genetics Program and Howard Hughes Medical Institute, Memorial Sloan Kettering Cancer Center, 1275 York Avenue, 1300 York Avenue, New York, NY 1002, USA
    Cell 117:211-23. 2004
    ..We suggest that the activity of this network confers resistance to TGF-beta-mediated cytostasis during the development of the telencephalic neuroepithelium and in glioblastoma brain tumor cells...
  2. ncbi request reprint p21(WAF1/CIP1) at the switch between the anti-oncogenic and oncogenic faces of TGFbeta
    Joan Seoane
    Laboratory of Oncology Research, Medical Oncology Service, Vall d Hebron University Hospital, Psg Vall d Hebron 119 129, 08035 Barcelona, Spain
    Cancer Biol Ther 3:226-7. 2004
  3. ncbi request reprint Myc suppression of the p21(Cip1) Cdk inhibitor influences the outcome of the p53 response to DNA damage
    Joan Seoane
    Cell Biology Program and Howard Hughes Medical Institute, Memorial Sloan Kettering Cancer Center, New York, NY 10021, USA
    Nature 419:729-34. 2002
    ..By inhibiting p21(Cip1) expression Myc favours the initiation of apoptosis, thereby influencing the outcome of a p53 response in favour of cell death...
  4. ncbi request reprint Escaping from the TGFbeta anti-proliferative control
    Joan Seoane
    Institucio Catalana de Recerca i Estudis Avancats ICREA, Medical Oncology Program Vall d Hebron University Hospital Research Institute, Barcelona, Spain
    Carcinogenesis 27:2148-56. 2006
    ..The understanding of how the TGFbeta signal is disrupted in cancer might facilitate the design and development of rational and successful therapeutic strategies...
  5. ncbi request reprint High TGFbeta-Smad activity confers poor prognosis in glioma patients and promotes cell proliferation depending on the methylation of the PDGF-B gene
    Alejandra Bruna
    Medical Oncology Program, Vall d Hebron University Hospital Research Institute, 08035 Barcelona, Spain
    Cancer Cell 11:147-60. 2007
    ..The epigenetic regulation of the PDGF-B gene dictates whether TGFbeta acts as an oncogenic factor inducing PDGF-B and proliferation in human glioma...
  6. ncbi request reprint Opposite Smad and chicken ovalbumin upstream promoter transcription factor inputs in the regulation of the collagen VII gene promoter by transforming growth factor-beta
    María Julia Calonge
    Cell Biology Program and Howard Hughes Medical Institute, Memorial Sloan Kettering Cancer Center, New York, New York 10021, USA
    J Biol Chem 279:23759-65. 2004
    ..The results suggest that TGF-beta signaling may exert tight control over COL7A1 by offsetting the balance between opposing Smad and COUP-TFs...
  7. ncbi request reprint Smad transcription factors
    Joan Massague
    Cancer Biology and Genetics Program, Howard Hughes Medical Institute, Memorial Sloan Kettering Cancer Center, New York, New York 10021, USA
    Genes Dev 19:2783-810. 2005
    ..Our growing understanding of TGFbeta signaling through the Smad pathway provides general principles for how animal cells translate complex inputs into concrete behavior...
  8. pmc A FoxO-Smad synexpression group in human keratinocytes
    Roger R Gomis
    Cancer Biology and Genetics Program, Howard Hughes Medical Institute, and Bioinformatics Core Facility, Memorial Sloan Kettering Cancer Center, New York, NY 10021, USA
    Proc Natl Acad Sci U S A 103:12747-52. 2006
    ..The composition of the FoxO-Smad synexpression group suggests that stress reactions and adaptive functions accompany the cytostatic response of keratinocytes to TGF-beta...
  9. ncbi request reprint TGF-beta signalling-related markers in cancer patients with bone metastasis
    Jose Baselga
    Vall d Hebron University Hospital, Barcelona, Spain
    Biomarkers 13:217-36. 2008
    ..PBMC were stimulated ex vivo to determine the individual biological variability of an ex vivo assay measuring pSMAD expression. This assay performed sufficiently well to allow its future use in a clinical trial of a TGF-beta inhibitor...