Francisco X Real

Summary

Affiliation: Hospital del Mar
Country: Spain

Publications

  1. pmc Bladder cancer risk and genetic variation in AKR1C3 and other metabolizing genes
    Jonine D Figueroa
    Division of Cancer Epidemiology and Genetics, National Cancer Institute, Department of Health and Human Services, Bethesda, MD, USA
    Carcinogenesis 29:1955-62. 2008
  2. ncbi Keratin 8 sequence variants in patients with pancreatitis and pancreatic cancer
    Matthias Treiber
    Department of Hepatology and Gastroenterology, Charite, Campus Virchow Klinikum, Universitatsmedizin Berlin, Berlin, Germany
    J Mol Med (Berl) 84:1015-22. 2006
  3. pmc Family history of cancer and germline BRCA2 mutations in sporadic exocrine pancreatic cancer
    F X Real
    Unitat de Biologia Cellular i Molecular, Institut Municipal d Investigacio Medica, Universitat Pompeu Fabra, Barcelona, Spain
    Gut 50:653-7. 2002
  4. ncbi A "catastrophic hypothesis" for pancreas cancer progression
    Francisco X Real
    Unitat de Biologia Cellular i Molecular, Institut Municipal d Investigacio Medica, Carrer del Dr Aiguader 80, 08003 Universitat Pompeu Fabra, Barcelona, Spain
    Gastroenterology 124:1958-64. 2003
  5. doi Lifetime history of alcohol consumption and K-ras mutations in pancreatic ductal adenocarcinoma
    Marta Crous-Bou
    Institut Municipal d Investigacio Medica, Barcelona, Spain
    Environ Mol Mutagen 50:421-30. 2009
  6. pmc Coffee consumption, genetic susceptibility and bladder cancer risk
    Cristina M Villanueva
    Centre for Research in Environmental Epidemiology CREAL, PRBB Building, Doctor Aiguader, 88, 08003, Barcelona, Spain
    Cancer Causes Control 20:121-7. 2009
  7. doi Galectin-1 is a novel functional receptor for tissue plasminogen activator in pancreatic cancer
    Oriol Roda
    Cancer Research Programme, Municipal Institute of Medical Research, Barcelona, Spain
    Gastroenterology 136:1379-90, e1-5. 2009
  8. pmc Murine embryonic stem cell-derived pancreatic acinar cells recapitulate features of early pancreatic differentiation
    Meritxell Rovira
    Cancer Research Program, Institut Municipal d Investigacio Medica, Barcelona, Spain
    Gastroenterology 135:1301-1310, 1310.e1-5. 2008
  9. ncbi Prospective study of FGFR3 mutations as a prognostic factor in nonmuscle invasive urothelial bladder carcinomas
    Silvia Hernandez
    Universitat Pompeu Fabra, Institut Municipal d Investigacio Medica, Hospital del Mar, Barcelona, Spain
    J Clin Oncol 24:3664-71. 2006
  10. ncbi The p53 pathway and outcome among patients with T1G3 bladder tumors
    Elena Lopez-Knowles
    Institut Municipal d Investigacio Medica, Universitat Pompeu Fabra, and Hospital del Mar, Barcelona, Spain
    Clin Cancer Res 12:6029-36. 2006

Detail Information

Publications83

  1. pmc Bladder cancer risk and genetic variation in AKR1C3 and other metabolizing genes
    Jonine D Figueroa
    Division of Cancer Epidemiology and Genetics, National Cancer Institute, Department of Health and Human Services, Bethesda, MD, USA
    Carcinogenesis 29:1955-62. 2008
    ..These results indicate that genetic variation in carcinogen-metabolizing genes, particularly AKR1C3, could be associated with bladder cancer risk...
  2. ncbi Keratin 8 sequence variants in patients with pancreatitis and pancreatic cancer
    Matthias Treiber
    Department of Hepatology and Gastroenterology, Charite, Campus Virchow Klinikum, Universitatsmedizin Berlin, Berlin, Germany
    J Mol Med (Berl) 84:1015-22. 2006
    ..6%) control subjects of African descent. Our data suggest that the KRT8 alterations, Y54H and G62C, do not predispose patients to the development of pancreatitis or pancreatic cancer...
  3. pmc Family history of cancer and germline BRCA2 mutations in sporadic exocrine pancreatic cancer
    F X Real
    Unitat de Biologia Cellular i Molecular, Institut Municipal d Investigacio Medica, Universitat Pompeu Fabra, Barcelona, Spain
    Gut 50:653-7. 2002
    ..Hereditary factors have been reported in 5-10% of cases with exocrine pancreatic cancer and recent data support a role for BRCA2...
  4. ncbi A "catastrophic hypothesis" for pancreas cancer progression
    Francisco X Real
    Unitat de Biologia Cellular i Molecular, Institut Municipal d Investigacio Medica, Carrer del Dr Aiguader 80, 08003 Universitat Pompeu Fabra, Barcelona, Spain
    Gastroenterology 124:1958-64. 2003
    ..If correct, this hypothesis has important implications regarding pancreas cancer research. Further work is warranted to examine this hypothesis and to identify the putative "catastrophic" elements participating in this tumor...
  5. doi Lifetime history of alcohol consumption and K-ras mutations in pancreatic ductal adenocarcinoma
    Marta Crous-Bou
    Institut Municipal d Investigacio Medica, Barcelona, Spain
    Environ Mol Mutagen 50:421-30. 2009
    ..We analyzed the relation between lifetime consumption of alcohol and mutations in codon 12 of the K-ras oncogene in patients with PDA...
  6. pmc Coffee consumption, genetic susceptibility and bladder cancer risk
    Cristina M Villanueva
    Centre for Research in Environmental Epidemiology CREAL, PRBB Building, Doctor Aiguader, 88, 08003, Barcelona, Spain
    Cancer Causes Control 20:121-7. 2009
    ..We evaluated the bladder cancer risk associated with coffee consumption in a case-control study in Spain and examined the gene-environment interactions for genetic variants of caffeine-metabolizing enzymes...
  7. doi Galectin-1 is a novel functional receptor for tissue plasminogen activator in pancreatic cancer
    Oriol Roda
    Cancer Research Programme, Municipal Institute of Medical Research, Barcelona, Spain
    Gastroenterology 136:1379-90, e1-5. 2009
    ..The aim was to analyze the role of galectin-1 (Gal-1), an endogenous lectin that also is overexpressed in PDA, as a new functional receptor for tPA...
  8. pmc Murine embryonic stem cell-derived pancreatic acinar cells recapitulate features of early pancreatic differentiation
    Meritxell Rovira
    Cancer Research Program, Institut Municipal d Investigacio Medica, Barcelona, Spain
    Gastroenterology 135:1301-1310, 1310.e1-5. 2008
    ..However, there are limited models to study normal acinar cell differentiation in vitro. The aim of this work was to generate and characterize purified populations of pancreatic acinar cells from embryonic stem (ES) cells...
  9. ncbi Prospective study of FGFR3 mutations as a prognostic factor in nonmuscle invasive urothelial bladder carcinomas
    Silvia Hernandez
    Universitat Pompeu Fabra, Institut Municipal d Investigacio Medica, Hospital del Mar, Barcelona, Spain
    J Clin Oncol 24:3664-71. 2006
    ..To determine the frequency and the prognostic value of fibroblast growth factor receptor 3 (FGFR3) mutations in patients with nonmuscle invasive bladder tumors according to tumor stage and grade...
  10. ncbi The p53 pathway and outcome among patients with T1G3 bladder tumors
    Elena Lopez-Knowles
    Institut Municipal d Investigacio Medica, Universitat Pompeu Fabra, and Hospital del Mar, Barcelona, Spain
    Clin Cancer Res 12:6029-36. 2006
    ..The aim was to analyze Tp53 and HDM2 in T1G3 bladder tumors and to determine the prognostic value of their alterations...
  11. pmc Tissue plasminogen activator induces pancreatic cancer cell proliferation by a non-catalytic mechanism that requires extracellular signal-regulated kinase 1/2 activation through epidermal growth factor receptor and annexin A2
    Elena Ortiz-Zapater
    Unitat de Biologia Cel lular i Molecular, Institut Municipal d Investigacio Medica, Barcelona, Spain
    Am J Pathol 170:1573-84. 2007
    ..These results add novel insights into the non-catalytic functions of tPA in cancer and the molecular mechanisms behind the effects of this protease on cell proliferation, including a role for epidermal growth factor receptor...
  12. doi CYP1B1 polymorphisms and k-ras mutations in patients with pancreatic ductal adenocarcinoma
    Marta Crous-Bou
    Institut Municipal d Investigacio Medica IMIM, CIBER de Epidemiología y Salud Pública CIBERESP, Barcelona, Spain
    Dig Dis Sci 53:1417-21. 2008
    ..The Val/Val genotype was over five times more frequent in PDA cases with a K-ras mutation than in wild-type cases (OR = 5.25; P = 0.121). In PDA, polymorphisms in CYP1B1 might be related with K-ras activation pathways...
  13. ncbi PIK3CA mutations are an early genetic alteration associated with FGFR3 mutations in superficial papillary bladder tumors
    Elena Lopez-Knowles
    Institut Municipal d Investigacio Medica, Universitat Pompeu Fabra, Carrer del Dr Aiguader 80, 08003 Barcelona, Spain
    Cancer Res 66:7401-4. 2006
    ..PIK3CA may constitute a novel diagnostic and prognostic tool, as well as a therapeutic target, in bladder cancer...
  14. ncbi Bulky DNA adduct formation and risk of bladder cancer
    Gemma Castano-Vinyals
    Centre for Research in Environmental Epidemiology, Institut Municipal d Investigacio Medica, Doctor Aiguader, 88, 08003 Barcelona, Spain
    Cancer Epidemiol Biomarkers Prev 16:2155-9. 2007
    ..Results do not support an association of bladder cancer risk with low-level exposure to PAHs as measured through the formation of bulky DNA adducts in peripheral mononuclear cells...
  15. ncbi Risk of bladder cancer associated with family history of cancer: do low-penetrance polymorphisms account for the increase in risk?
    Cristiane Murta-Nascimento
    Institut Municipal d Investigacio Medica, Carrer del Dr Aiguader 88, E 08003, Barcelona, Spain
    Cancer Epidemiol Biomarkers Prev 16:1595-600. 2007
    ..Whether these correspond to low-penetrance cancer-predisposing polymorphisms acting together and/or interacting with environmental factors warrants further research...
  16. doi Relationships of hepatic and pancreatic biomarkers with the cholestatic syndrome and tumor stage in pancreatic cancer
    Miquel Porta
    Hospital del Mar Research Institute IMIM, Barcelona, Catalonia, Spain
    Biomarkers 17:557-65. 2012
    ..Relationships of hepatic and pancreatic biomarkers with pancreatic symptoms and tumor stage must be controlled in "-omics" and other studies using biomarkers...
  17. ncbi Viral-mediated coexpression of Pdx1 and p48 regulates exocrine pancreatic differentiation in mouse ES cells
    Meritxell Rovira
    Cell and Molecular Biology Unit, Institut Municipal d Investigacio Medica IMIM, Dr Aiguader 88, Barcelona, Spain
    Cloning Stem Cells 9:327-38. 2007
    ..Therefore, combined expression of key genes involved in pancreatic development may be a promising approach to generate mature pancreatic exocrine cells...
  18. doi Cigarette smoking and K-ras mutations in pancreas, lung and colorectal adenocarcinomas: etiopathogenic similarities, differences and paradoxes
    Miquel Porta
    Institut Municipal d Investigacio Medica, Barcelona, Spain
    Mutat Res 682:83-93. 2009
    ....
  19. doi Key contribution of CPEB4-mediated translational control to cancer progression
    Elena Ortiz-Zapater
    Cancer Research Programme, Hospital del Mar Research Institute IMIM, Barcelona, Spain
    Nat Med 18:83-90. 2012
    ..Taken together, our results document a key role for post-transcriptional gene regulation in tumor development and describe a detailed mechanism for gene expression reprogramming underlying malignant tumor progression...
  20. doi FDG PET imaging of Ela1-myc mice reveals major biological differences between pancreatic acinar and ductal tumours
    Ibane Abasolo
    Institut Municipal d Investigació Mèdica Hospital del Mar, Parc de Recerca Biomedica de Barcelona, Carrer del Dr Aiguader, 88, 08003, Barcelona, Spain
    Eur J Nucl Med Mol Imaging 36:1156-66. 2009
    ..The aim was to evaluate FDG PET imaging in Ela1-myc mice, a pancreatic cancer model resulting in the development of tumours with either acinar or mixed acinar-ductal phenotype...
  21. doi The epigenetic regulators Bmi1 and Ring1B are differentially regulated in pancreatitis and pancreatic ductal adenocarcinoma
    Carles Martínez-Romero
    Institut Municipal d Investigacio Medica, Hospital del Mar, Barcelona, Spain
    J Pathol 219:205-13. 2009
    ..Our results suggest that Bmi1 and Ring1B are modulated in pancreatic diseases and could contribute differently to tumour development...
  22. doi p/CAF modulates the activity of the transcription factor p48/Ptf1a involved in pancreatic acinar differentiation
    Annie Rodolosse
    Departament de Ciencies Experimentals i de la Salut, Universitat Pompeu Fabra, Doctor Aiguader 88, 08003 Barcelona, Spain
    Biochem J 418:463-73. 2009
    ..In contrast, p/CAF did not co-operate with p48 in its growth regulatory effects. These results support a critical and selective role of p/CAF in PTF1-dependent gene activation during acinar differentiation...
  23. ncbi Lifetime history of tobacco consumption and K-ras mutations in exocrine pancreatic cancer
    Marta Crous-Bou
    Institut Municipal d Investigacio Medica, Barcelona, Spain
    Pancreas 35:135-41. 2007
    ..We analyzed the relation between mutations in codon 12 of the K-ras oncogene and lifetime consumption of tobacco in patients with exocrine pancreatic cancer (EPC)...
  24. doi Keratin 7 promoter selectively targets transgene expression to normal and neoplastic pancreatic ductal cells in vitro and in vivo
    Judit Pujal
    Unitat de Biologia Cellular i Molecular, Institut Municipal d Investigacio Medica, Parc de Recerca Biomedica de Barcelona, Barcelona, Spain
    FASEB J 23:1366-75. 2009
    ..In conclusion, the krt7 promoter is useful to target pancreatic ductal adenocarcinoma cells in vitro and in vivo...
  25. doi Bladder cancer and seroreactivity to BK, JC and Merkel cell polyomaviruses: the Spanish bladder cancer study
    Claudia Robles
    Unit of Infections and Cancer, Cancer Epidemiology Research Programme, Catalan Institute of Oncology, IDIBELL, 08908 L Hospitalet de Llobregat, Barcelona, Spain
    Int J Cancer 133:597-603. 2013
    ..Furthermore, no association was observed between seroresponse to JCV and bladder cancer. Therefore, we conclude that BKV and MCV polyomavirus infection could be related to an increased bladder cancer risk...
  26. ncbi Bladder cancer and exposure to water disinfection by-products through ingestion, bathing, showering, and swimming in pools
    Cristina M Villanueva
    Centre for Research in Environmental Epidemiology, Municipal Institute of Medical Research, Barcelona, Spain
    Am J Epidemiol 165:148-56. 2007
    ..57 (95% confidence interval: 1.18, 2.09). Bladder cancer risk was associated with long-term exposure to THMs in chlorinated water at levels regularly occurring in industrialized countries...
  27. ncbi PTF1alpha/p48 transcription factor couples proliferation and differentiation in the exocrine pancreas [corrected]
    Annie Rodolosse
    Unitat de Biologia Cellular i Molecular, Institut Municipal d Investigacio Medica, Barcelona, Spain
    Gastroenterology 127:937-49. 2004
    ..The aim was to analyze the ability of p48 to modulate cell proliferation, its relationship with cell differentiation, and the mechanisms involved therein...
  28. ncbi In vitro differentiation of HT-29 M6 mucus-secreting colon cancer cells involves a trychostatin A and p27(KIP1)-inducible transcriptional program of gene expression
    Clara Mayo
    Unitat de Biologia Celñlular i Molecular, Institut Municipal d Investigacio Medica, Barcelona, Spain
    J Cell Physiol 212:42-50. 2007
    ..Therefore, the HT-29 M6 model allows the identification of some basic mechanisms of cancer cell differentiation control, so far revealing HDAC and p27(KIP1) as key regulatory factors of differentiation gene expression...
  29. ncbi Role of the basic helix-loop-helix transcription factor p48 in the differentiation phenotype of exocrine pancreas cancer cells
    T Adell
    Unitat de Biologia Cellular i Molecular, Institut Municipal d Investigacio Medica, Universitat Pompeu Fabra, Barcelona, Spain
    Cell Growth Differ 11:137-47. 2000
    ..Together with prior work, our findings indicate that p48 is associated with the acinar phenotype of exocrine pancreas cancers and it is necessary, but not sufficient, for the expression of the acinar phenotype...
  30. pmc Tissue plasminogen activator in murine exocrine pancreas cancer: selective expression in ductal tumors and contribution to cancer progression
    Susana Aguilar
    Unitat de Biologia Cellular i Molecular, Institut Municipal d Investigacio Medica, Dr Aiguader, 80, 08003 Barcelona, Spain
    Am J Pathol 165:1129-39. 2004
    ..Our findings indicate that murine and human pancreatic ductal tumors share molecular alterations in the tPA system that may play a role in tumor progression...
  31. ncbi Fibroblast growth factor receptor 3 mutations in epidermal nevi and associated low grade bladder tumors
    Silvia Hernandez
    Department de Ciències Experimentals i de la Salut, Universitat Pompeu Fabra, Barcelona, Spain
    J Invest Dermatol 127:1664-6. 2007
    ..1%) EN but it was absent from unaffected skin. In two patients with EN and UC, both lesions were FGFR3 wild type. Our findings indicate that: (1) FGFR3 mutations occur in mosaicism and can cause EN and (2) other genes are involved in EN...
  32. ncbi Epidemiology of urinary bladder cancer: from tumor development to patient's death
    Cristiane Murta-Nascimento
    Centre de Recerca en Epidemiologia Ambiental CREAL, Institut Municipal d Investigacio Medica IMIM, Carrer del Dr Aiguader 88, 08003, Barcelona, Spain
    World J Urol 25:285-95. 2007
    ..Subgroup analysis according to stage, grade, and molecular features may help in identifying specific etiological and prognostic factors involved in different bladder cancer progression pathways...
  33. pmc Mosaic uniparental disomies and aneuploidies as large structural variants of the human genome
    Benjamín Rodríguez-Santiago
    Departament de Ciencies Experimentals i de la Salut, Universitat Pompeu Fabra, E 08003 Barcelona, Spain
    Am J Hum Genet 87:129-38. 2010
    ....
  34. ncbi A proteomic approach to the identification of new tPA receptors in pancreatic cancer cells
    Oriol Roda
    Department of Experimental and Health Sciences, Pompeu Fabra University, Barcelona, Spain
    Proteomics 6:S36-41. 2006
    ..Confirmation of the results was performed for some of these proteins using immunoblotting. These studies are the basis for further functional analyses on the role of these proteins in the biological effects of tPA...
  35. ncbi P53 as a prognostic marker for bladder cancer: a meta-analysis and review
    Nuria Malats
    Municipal Institute of Medical Investigation, Barcelona, Spain
    Lancet Oncol 6:678-86. 2005
    ..P53 is the most widely investigated molecular marker in bladder cancer. We aimed to review comprehensively the evidence for use of changes in P53 to predict bladder-cancer recurrence, progression, and mortality...
  36. doi Pancreatic ductal adenocarcinoma: cellular origin, signaling pathways and stroma contribution
    Inmaculada Hernández-Muñoz
    Programa de Recerca en Càncer, Institut Municipal d Investigació Mèdica IMIM Hospital del Mar, Barcelona, Spain
    Pancreatology 8:462-9. 2008
    ..An improved understanding of these key aspects for PDAC ontogeny will open new avenues for tumor prevention, early detection, and improved therapy...
  37. ncbi Hair dye use is not associated with risk for bladder cancer: evidence from a case-control study in Spain
    Manolis Kogevinas
    Municipal Institute of Medical Research, Centre for Research in Environmental Epidemiology CREAL, Respiratory and Environmental Health Research Unit, Dr Aiguader 80, 08003 Barcelona, Spain
    Eur J Cancer 42:1448-54. 2006
    ..None of the polymorphisms examined significantly modified the hair dye associated risk. Overall, this study does not support an association between hair dye use and bladder cancer...
  38. doi In pancreatic ductal adenocarcinoma blood concentrations of some organochlorine compounds and coffee intake are independently associated with KRAS mutations
    Miquel Porta
    Institut Municipal d Investigació Mèdica Hospital del Mar, E 08003 Barcelona, Catalonia, Spain
    Mutagenesis 24:513-21. 2009
    ..Given that KRAS mutations are the most frequent abnormality of oncogenes in human cancers, and the lifelong accumulation of OCs in humans, refutation or replication of the findings is required before any implications are assessed...
  39. doi Correcting serum concentrations of organochlorine compounds by lipids: alternatives to the organochlorine/total lipids ratio
    Miquel Porta
    Institut Municipal d Investigació Mèdica Hospital del Mar, E 08003 Barcelona, Catalonia, Spain
    Environ Int 35:1080-5. 2009
    ..Our aim was to analyze the relationship between serum OC and TL in patients with pancreatic ductal adenocarcinoma (PDA), and to explore several alternatives to perform the OC lipid correction...
  40. ncbi Use of analgesics and nonsteroidal anti-inflammatory drugs, genetic predisposition, and bladder cancer risk in Spain
    Joan Fortuny
    Centre for Research in Environmental Epidemiology, Municipal Institute of Medical Research, Autonomous University of Barcelona corrected Barcelona, Catalonia, Spain
    Cancer Epidemiol Biomarkers Prev 15:1696-702. 2006
    ....
  41. ncbi Pancreas transcription factor 1alpha expression is regulated in pancreatitis
    X Molero
    Research Institute, Vall d Hebron University Hospital, Autonomous University of Barcelona, Barcelona, Spain
    Eur J Clin Invest 37:791-801. 2007
    ..Expression of acinar cell-specific genes requires the pancreas transcription factor 1alpha (Ptf1alpha). p48 is the only component of Ptf1alpha that is involved in both acinar gene regulation and pancreatic ontogenesis...
  42. pmc Incomplete overlapping of biological, clinical, and environmental information in molecular epidemiological studies: a variety of causes and a cascade of consequences
    M Porta
    Institut Municipal d Investigacio Medica, Universitat Autònoma de Barcelona and Universitat Pompeu Fabra, Barcelona, Spain
    J Epidemiol Community Health 56:734-8. 2002
  43. ncbi Validity of the hospital discharge diagnosis in epidemiologic studies of biliopancreatic pathology. PANKRAS II Study Group
    M Porta
    Institut Municipal d Investigacio Medica, Universitat Autonoma de Barcelona, Spain
    Eur J Epidemiol 16:533-41. 2000
    ....
  44. ncbi Regulation of mucin and glycoconjugate expression: from normal epithelium to gastric tumors
    C de Bolos
    Unitat de Biologia Cellular i Molecular, Institut Municipal d Investigacio Medica, Universitat Pompeu Fabra, Barcelona, Spain
    Front Biosci 6:D1256-63. 2001
    ....
  45. ncbi In vitro analysis of the role of DCC in mucus-secreting intestinal differentiation
    M Fabre
    Unitat de Biologia Cellular i Molecular, Institut Municipal d Investigacio Medica, Universitat Pompeu Fabra, Barcelona, Spain
    Int J Cancer 81:799-807. 1999
    ..Our results indicate that DCC is not selectively involved in the mucosecretory differentiation pathway and that it is neither sufficient nor essential for normal intestinal differentiation...
  46. ncbi Expressed sequence tag (EST) phenotyping of HT-29 cells: cloning of ser/thr protein kinase EMK1, kinesin KIF3B, and of transcripts that include Alu repeated elements
    E Navarro
    Unitat de Biologia Cel lular i Molecular, Institut Municipal d Investigacio Medica IMIM, C Dr Aiguader 80, E 08003, Barcelona, Spain
    Biochim Biophys Acta 1450:254-64. 1999
    ..The significance of the transcripts cloned is discussed in the context of the commitment and differentiation of the M6 cells to the mucus secreting lineage of epithelial cells...
  47. ncbi Serum concentrations of organochlorine compounds and K-ras mutations in exocrine pancreatic cancer. PANKRAS II Study Group
    M Porta
    Institut Municipal d Investigacio Medica, Universitat Autonoma de Barcelona, Spain
    Lancet 354:2125-9. 1999
    ..We analysed the relation between serum concentrations of selected organochlorine compounds and mutations in codon 12 of the K-ras gene in patients with exocrine pancreatic cancer...
  48. pmc Cystic fibrosis transmembrane regulator (CFTR) DeltaF508 mutation and 5T allele in patients with chronic pancreatitis and exocrine pancreatic cancer. PANKRAS II Study Group
    N Malats
    Grup de Recerca d Epidemiologia Clínica i Molecular del Càncer, Institut Municipal d Investigacio Medica, Universitat Pompeu Fabra, Barcelona, Universitat Autonoma de Barcelona, Spain
    Gut 48:70-4. 2001
    ..An increased risk of chronic pancreatitis has been described among carriers of the cystic fibrosis transmembrane regulator (CFTR) mutation. In addition, patients with cystic fibrosis may have a higher risk of exocrine pancreatic cancer...
  49. pmc Assessment of lifetime exposure to trihalomethanes through different routes
    C M Villanueva
    Respiratory and Environmental Health Research Unit, Institut Municipal d Investigacio Medica IMIM, Barcelona, Spain
    Occup Environ Med 63:273-7. 2006
    ..The study base was comprised of subjects living in the catchment areas of the participating hospitals...
  50. ncbi Somatic oncogenic mutations, benign skin lesions and cancer progression: where to look next?
    Agusti Toll
    Department of Dermatology, Hospital del Mar, Barcelona, Spain
    Cell Cycle 7:2674-81. 2008
    ..In this review, we focus on new candidate genes for discovery and we outline the potential of the skin as a model to achieve a better understanding of cancer biology...
  51. ncbi Mucins as differentiation markers in bronchial epithelium. Squamous cell carcinoma and adenocarcinoma display similar expression patterns
    A Lopez-Ferrer
    Unitat de Biologia Cellular i Molecular, Institut Municipal d Investigacio Medica, Barcelona Servei de Pneumologia and Servei de Patologia, Hospital de Mar, Barcelona and Universitat Pompeu Fabra, Barcelona, Spain
    Am J Respir Cell Mol Biol 24:22-29. 2001
    ....
  52. doi Ribonucleoprotein HNRNPA2B1 interacts with and regulates oncogenic KRAS in pancreatic ductal adenocarcinoma cells
    Carles Barceló
    Departament de Biologia Cellular, Immunologia i Neurociencies, Facultat de Medicina, IDIBAPS, Universitat de Barcelona, Barcelona, Spain
    Gastroenterology 147:882-892.e8. 2014
    ..We investigated the activities of proteins that interact with KRAS in PDAC cells...
  53. ncbi FGFR3 and Tp53 mutations in T1G3 transitional bladder carcinomas: independent distribution and lack of association with prognosis
    Silvia Hernandez
    Universitat Pompeu Fabra, Institut Municipal d Investigacio Medica, Hospital del Mar, Barcelona, Spain
    Clin Cancer Res 11:5444-50. 2005
    ..15-13.75), wt/mut 0.67 (0.19-2.31), mut/mut 1.62 (0.27-9.59). These molecular features support the notion that T1G3 tumors are at the crossroads of the two main molecular pathways proposed for bladder cancer development and progression...
  54. ncbi Exocrine pancreatic cancer: symptoms at presentation and their relation to tumour site and stage
    Miquel Porta
    Unidad de Epidemiología Clinica y Molecular del Cáncer, Instituto Municipal de Investigacion Medica, Universidad Autonoma de Barcelona, Carrer del Dr Aiguader 80, 08005 Barcelona, Spain
    Clin Transl Oncol 7:189-97. 2005
    ..We recorded the signs and symptoms of patients presenting with exocrine pancreatic cancer and evaluated their association with clinical characteristics such as tumour site and disease stage...
  55. ncbi Molecular biology of bladder cancer
    Nuno M Luis
    Unitat de Biologia Cellular i Molecular, Institut Municipal d Investigacio Medica, Barcelona, Spain
    Clin Transl Oncol 9:5-12. 2007
    ..Distinct gene expression profiles have been identified in superficial and invasive tumors. The stage is now ready for the clinical application of this knowledge...
  56. pmc Interaction between Hhex and SOX13 modulates Wnt/TCF activity
    Vanessa Marfil
    Unitat de Biologia Cellular i Molecular, Institut Municipal d Investigacio Medica, Universitat Pompeu Fabra, Barcelona 08003, Spain
    J Biol Chem 285:5726-37. 2010
    ..We conclude that the interaction between Hhex and SOX13 may contribute to control Wnt/TCF signaling in the early embryo...
  57. doi Next-generation sequencing of urologic cancers: next is now
    Francisco X Real
    Epithelial Carcinogenesis Group, CNIO Spanish National Cancer Research Center, Madrid, Spain Departament de Ciéncies Experimentals i de la Salut, Universitat Pompeu Fabra, Barcelona, Spain Electronic address
    Eur Urol 66:4-7. 2014
    ..This sequencing has unveiled new genes that are altered and new opportunities for tumour subclassification, prediction of outcome, and therapy. These opportunities will soon become realities...
  58. ncbi Generalizing molecular results arising from incomplete biological samples: expected bias and unexpected findings
    Miquel Porta
    Institut Municipal d Investigacio Medica, Universitat Autonoma de Barcelona, Barcelona, Catalonia, Spain
    Ann Epidemiol 12:7-14. 2002
    ..Here we report some expected bias and some unexpected findings during a study on mutations in the K-ras gene in exocrine pancreatic cancer (EPC)...
  59. ncbi The Wnt pathway is active in a small subset of pancreas cancer cell lines
    Judit Pujal
    Unitat de Biologia Cellular i Molecular, Institut Municipal d Investigacio Medica, Barcelona, Spain
    Biochim Biophys Acta 1762:73-9. 2006
    ..Additional studies on the role of Wnt pathway components in the development/progression of tumors of the peripancreatic region merit consideration...
  60. ncbi DCC regulates cell adhesion in human colon cancer derived HT-29 cells and associates with ezrin
    Merce Martin
    Unitat de Biologia Cel lular i Molecular, Institut Municipal d Investigacio Medica, Universitat Pompeu Fabra, Barcelona, Spain
    Eur J Cell Biol 85:769-83. 2006
    ..Altogether, our results suggest that DCC could regulate cell adhesion and migration through its association with ERM-M proteins...
  61. pmc Transforming growth factor (TGF)beta, fibroblast growth factor (FGF) and retinoid signalling pathways promote pancreatic exocrine gene expression in mouse embryonic stem cells
    Anouchka Skoudy
    Unitat de Biologia Cel lular i Molecular, Institut Municipal d Investigacio Medica, 08003 Barcelona, Spain
    Biochem J 379:749-56. 2004
    ....
  62. ncbi Benzyl-N-acetyl-alpha-D-galactosaminide induces a storage disease-like phenotype by perturbing the endocytic pathway
    Fausto Ulloa
    Unitat de Biologia Celular i Molecular, Institut Municipal d Investigacio Medica, Universitat Pompeu Fabra, Barcelona 08003, Spain
    J Biol Chem 278:12374-83. 2003
    ..We propose that abnormal subcellular distribution of membrane glycoproteins involved in cellular communication and/or signaling may also take place in lysosomal storage disorders and may contribute to their pathogenesis...
  63. ncbi New insights into the tPA-annexin A2 interaction. Is annexin A2 CYS8 the sole requirement for this association?
    Oriol Roda
    Departament de Ciències Experimentales i de la Salut, Facultat de Ciencies de la Salut i de la Vida, Universitat Pompeu Fabra and Unitat de Biologia Cel lular i Molecular, Institut Municipal d Investigacio Medica, 08003 Barcelona, Spain
    J Biol Chem 278:5702-9. 2003
    ..These data call for a revision of the role of the LCKLSL sequence as the sole annexin A2 structural region required to bind tPA and indicate that further studies are necessary to better define the annexin A2-tPA interaction...
  64. ncbi Notch inhibits Ptf1 function and acinar cell differentiation in developing mouse and zebrafish pancreas
    Farzad Esni
    Department of Surgery, Johns Hopkins University School of Medicine, Baltimore, MD 21287, USA
    Development 131:4213-24. 2004
    ..These results define a normal inhibitory role for Notch in the regulation of exocrine pancreatic differentiation...
  65. pmc Diabetes and exocrine pancreatic insufficiency in E2F1/E2F2 double-mutant mice
    Ainhoa Iglesias
    Department of Genetics, Physical Anthropology and Animal Physiology, Faculty of Sciences, University of the Basque Country, Bilbao, Spain
    J Clin Invest 113:1398-407. 2004
    ..These results suggest that E2F1/E2F2 activity negatively controls growth of mature pancreatic cells and is necessary for the maintenance of differentiated pancreatic phenotypes in the adult...
  66. pmc NAT2 slow acetylation, GSTM1 null genotype, and risk of bladder cancer: results from the Spanish Bladder Cancer Study and meta-analyses
    Montserrat Garcia-Closas
    Division of Cancer Epidemiology and Genetics, National Cancer Institute, Department of Health and Human Services, Bethesda, MD 20852 7234, USA
    Lancet 366:649-59. 2005
    ..Associations between polymorphisms in other NAT and GST genes and bladder-cancer risk have been inconsistent...
  67. ncbi Smoking and bladder cancer in Spain: effects of tobacco type, timing, environmental tobacco smoke, and gender
    Claudine Samanic
    Division of Cancer Epidemiology and Genetics, National Cancer Institute, Department of Health and Human Services, Bethesda, MD 20892, USA
    Cancer Epidemiol Biomarkers Prev 15:1348-54. 2006
    ..2 to 1.7, suggesting that nearly the entire male excess of bladder cancer observed in Spain is explained by cigarette smoking rather than occupational/environmental exposures to other bladder carcinogens...
  68. pmc Cerebellar GABAergic progenitors adopt an external granule cell-like phenotype in the absence of Ptf1a transcription factor expression
    Marta Pascual
    Institut de Recerca Biomèdica, Parc Cientific de Barcelona, Universitat de Barcelona, Josep Samitier 1 5, E 08028 Barcelona, Spain
    Proc Natl Acad Sci U S A 104:5193-8. 2007
    ..Moreover, our results suggest that Ptf1a is also required for the suppression of the granule cell specification program in cerebellar ventricular zone precursors...
  69. ncbi Characterization of human Rab20 overexpressed in exocrine pancreatic carcinoma
    Jean Michel Amillet
    FRE 2584 CNRS, Institut Curie, 26 Rue d Ulm, 75248 Paris Cedex 05, France
    Hum Pathol 37:256-63. 2006
    ..Rab20 was also detected in preneoplastic pancreatic intraductal neoplasia lesions, suggesting that its up-regulation may be an early event in pancreatic carcinogenesis...
  70. ncbi Genetic variation in the nucleotide excision repair pathway and bladder cancer risk
    Montserrat Garcia-Closas
    Hormonal and Reproductive Epidemiology Branch, Division of Cancer Epidemiology and Genetics, National Cancer Institute, NIH, Room 7076, 6120 Executive Boulevard, MSC 7234, Rockville, MD 20852 7234, USA
    Cancer Epidemiol Biomarkers Prev 15:536-42. 2006
    ..A detailed characterization of genetic variation in key NER genes is warranted and might ultimately help identify multiple susceptibility variants that could be responsible for substantial joint increases in risk...
  71. pmc Total fluid and water consumption and the joint effect of exposure to disinfection by-products on risk of bladder cancer
    Dominique S Michaud
    Department of Epidemiology, Harvard School of Public Health, Boston, Massachusetts 02115, USA
    Environ Health Perspect 115:1569-72. 2007
    ..A pooled analysis based on six case-control studies observed a positive association between tap water and bladder cancer but none for nontap fluid intake, suggesting that contaminants in tap water may be responsible for the excess risk...
  72. ncbi Genetic variation in the base excision repair pathway and bladder cancer risk
    Jonine D Figueroa
    Division of Cancer Epidemiology and Genetics, Department of Health and Human Services, National Cancer Institute, Bethesda, MD, USA
    Hum Genet 121:233-42. 2007
    ..24 (1.02-1.51) and 1.30 (1.04-1.62), respectively. In summary, data from this large case-control study suggested bladder cancer risk associations with selected BER SNPs, which need to be confirmed in other study populations...
  73. pmc Genomic DNA hypomethylation as a biomarker for bladder cancer susceptibility in the Spanish Bladder Cancer Study: a case-control study
    Lee E Moore
    Division of Cancer Epidemiology and Genetics, National Cancer Institute, Department of Health and Human Services, Rockville, MD, USA
    Lancet Oncol 9:359-66. 2008
    ..DNA hypomethylation has been suggested to cause genomic instability and increase cancer risk. We aimed to test the hypothesis that DNA hypomethylation is associated with increased risk of bladder cancer...
  74. pmc Food and nutrient intakes and K-ras mutations in exocrine pancreatic cancer
    Eva Morales
    Clinical and Molecular Epidemiology of Cancer Unit, Institut Municipal d Investigacio Medica IMIM, Universitat Autonoma de Barcelona, Carrer del Dr Aiguader 88, E 08003 Barcelona, Spain
    J Epidemiol Community Health 61:641-9. 2007
    ..No studies have investigated the relation between K-ras mutations and dietary factors in exocrine pancreatic cancer (EPC), and fewer than 10 studies have done so in other neoplasms...
  75. pmc Large-scale evaluation of candidate genes identifies associations between VEGF polymorphisms and bladder cancer risk
    Montserrat Garcia-Closas
    Division of Cancer Epidemiology and Genetics, National Cancer Institute, Department of Health and Human Services, Bethesda, Maryland, United States of America
    PLoS Genet 3:e29. 2007
    ..In conclusion, this large-scale evaluation of candidate cancer genes has identified common genetic variants in the regulatory regions of VEGF that could be associated with bladder cancer risk...
  76. ncbi Bladder cancer and apoptosis: matters of life and death
    Francisco X Real
    Lancet Oncol 8:91-2. 2007
  77. ncbi Evaluation of genetic variation in the double-strand break repair pathway and bladder cancer risk
    Jonine D Figueroa
    Division of Cancer Epidemiology and Genetics, National Cancer Institute, Department of Health and Human Services, Bethesda, MD, USA
    Carcinogenesis 28:1788-93. 2007
    ..17 (1.00-1.36). Results from this study provide evidence for associations between variants in genes in the DSBR pathway and bladder cancers risk that warrant replication in other study populations...
  78. ncbi Gene expression signatures predict outcome in non-muscle-invasive bladder carcinoma: a multicenter validation study
    Lars Dyrskjøt
    Molecular Diagnostic Laboratory, Department of Clinical Biochemistry, Aarhus University Hospital, Skejby, Denmark
    Clin Cancer Res 13:3545-51. 2007
    ..Here, we validated four previously reported gene expression signatures for molecular diagnosis of disease stage and carcinoma in situ (CIS) and for predicting disease recurrence and progression...
  79. ncbi Unique mechanisms of growth regulation and tumor suppression upon Apc inactivation in the pancreas
    Alessandra Strom
    Department of Genetic Medicine and Development, University of Geneva Faculty of Medicine, 1 rue Michel Servet, CH 1211 Geneva 4, Switzerland
    Development 134:2719-25. 2007
    ..This provides new insights into the mechanisms of tumor pathogenesis and tumor suppression in the pancreas...
  80. ncbi Polymorphisms in one-carbon metabolism and trans-sulfuration pathway genes and susceptibility to bladder cancer
    Lee E Moore
    Division of Cancer Epidemiology and Genetics, National Cancer Institute, National Institutes of Health, Department of Health and Human Services, Rockville, MD, USA
    Int J Cancer 120:2452-8. 2007
    ..Additional work is needed to comprehensively evaluate genomic variation in CTH and related genes in the trans-sulfuration pathway and bladder cancer risk...
  81. ncbi p53: it has it all, but will it make it to the clinic as a marker in bladder cancer?
    Francisco X Real
    J Clin Oncol 25:5341-4. 2007
  82. doi Does increased urination frequency protect against bladder cancer?
    Debra T Silverman
    Division of Cancer Epidemiology and Genetics, National Cancer Institute, Department of Health and Human Services, Bethesda, MD 20892, USA
    Int J Cancer 123:1644-8. 2008
    ..Increased urination frequency, coupled with possible dilution of the urine from increased water intake, may diminish the effect of urinary carcinogens on bladder cancer risk...
  83. doi Pancreatic cancer development and progression: remodeling the model
    Francisco X Real
    Programa de Patologia Molecular, Centro Nacional de Investigaciones Oncologicas, Madrid, Spain
    Gastroenterology 135:724-8. 2008