Lluis Espinosa

Summary

Affiliation: Hospital del Mar
Country: Spain

Publications

  1. pmc Prostate tumor OVerexpressed-1 (PTOV1) down-regulates HES1 and HEY1 notch targets genes and promotes prostate cancer progression
    Lide Alaña
    Research Unit in Biomedicine and Translational Oncology, Vall d Hebron Research Institute, PG, Vall d Hebron 119 129, Barcelona 08035, Spain
    Mol Cancer 13:74. 2014
  2. pmc The Notch/Hes1 pathway sustains NF-κB activation through CYLD repression in T cell leukemia
    Lluis Espinosa
    Cancer Research Program, Institut Municipal d Investigacions Mediques, IMIM, Hospital del Mar, 08003 Barcelona, Spain
    Cancer Cell 18:268-81. 2010
  3. pmc Hes repressors are essential regulators of hematopoietic stem cell development downstream of Notch signaling
    Jordi Guiu
    Program in Cancer Research, Hospital del Mar Medical Research Institute, IMIM, Barcelona Biomedical Research Park, 08003 Barcelona, Spain
    J Exp Med 210:71-84. 2013
  4. doi request reprint The Notch pathway in hematopoietic stem cells
    Anna Bigas
    Program in Cancer Research Institut Mar Investigacions Mèdiques IMIM, Hospital del Mar, Parc de Recerca Biomedica de Barcelona, Dr Aiguader 88, 08003, Barcelona, Spain
    Curr Top Microbiol Immunol 360:1-18. 2012
  5. pmc Hematopoietic stem cell development requires transient Wnt/β-catenin activity
    Cristina Ruiz-Herguido
    Program in Cancer Research, Institut Hospital del Mar d Investigacions Mèdiques, Parc de Recerca Biomedica de Barcelona, 08003 Barcelona, Spain
    J Exp Med 209:1457-68. 2012
  6. doi request reprint The Notch pathway in the developing hematopoietic system
    Anna Bigas
    Program in Cancer Research, IMIM Hospital del Mar, Barcelona, Spain
    Int J Dev Biol 54:1175-88. 2010
  7. doi request reprint Active nuclear IKK correlates with metastatic risk in cutaneous squamous cell carcinoma
    Agusti Toll
    Department of Dermatology, Hospital del Mar, Parc de Salut Mar, Barcelona, Spain
    Arch Dermatol Res 307:721-9. 2015
  8. pmc Identification of Cdca7 as a novel Notch transcriptional target involved in hematopoietic stem cell emergence
    Jordi Guiu
    Program de Recerca en Càncer, Institut Hospital del Mar d Investigacions Mèdiques, Parc de Recerca Biomedica de Barcelona, 08003 Barcelona, Spain
    J Exp Med 211:2411-23. 2014
  9. doi request reprint Notch1 Pathway Activation Results from the Epigenetic Abrogation of Notch-Related MicroRNAs in Mycosis Fungoides
    Fernando Gallardo
    Servei de Dermatologia, Hospital del Mar, Universitat Autonoma de Barcelona, Barcelona, Spain
    J Invest Dermatol 135:3144-52. 2015
  10. pmc Deficiency in p53 is required for doxorubicin induced transcriptional activation of NF-кB target genes in human breast cancer
    Alba Dalmases
    Cancer Research Program, IMIM Hospital del Mar Research Institute, Barcelona, Spain
    Oncotarget 5:196-210. 2014

Collaborators

  • Beatriz Bellosillo
  • Mar Iglesias
  • Klaus Rajewsky
  • Blanca Espinet
  • Olafur Andri Stefansson
  • Ignasi Tusquets
  • Pilar Eroles
  • Ross L Levine
  • Anna Bigas
  • Masayuki Yamamoto
  • Iannis Aifantis
  • Emery H Bresnick
  • Stuart T Fraser
  • Omar Abdel-Wahab
  • Alexander Statnikov
  • Shi Yong Sun
  • Jordi Guiu
  • Cristina Ruiz-Herguido
  • Alba Dalmases
  • Teresa D'Altri
  • Elaine Dzierzak
  • Pol Margalef
  • Julia Inglés-Esteve
  • Fernando Gallardo
  • Ramon Maria Pujol
  • Agusti Toll
  • Jessica Gonzalez
  • Lide Alaña
  • Federico Rojo
  • Ana Rovira
  • Joan Albanell
  • Nuria Lopez-Bigas
  • Ricard Garcia-Carbonell
  • Ana Belen Crujeiras
  • María Inmaculada Hernández
  • Javier Gimeno
  • Víctor Alegre
  • Angel Díaz-Lagares
  • Juan Sandoval
  • Octavio Servitje
  • Emili Masferrer
  • Carla Ferrándiz-Pulido
  • Ricard Garcia
  • Manel Esteller
  • Ibane Abasolo
  • Oriol Arpi
  • Raúl Rincón
  • Marta Sesé
  • Montserrat Corominas
  • Emma de Pater
  • Silvia Menendez
  • Timothy M Thomson
  • Josep Maria Corominas
  • Veronica Ayllon
  • Verónica Cánovas
  • Yolanda Punyal
  • Yolanda Fernandez
  • Santiago Ramon Y Cajal
  • Leonor Gama-Norton
  • Ines de Torres
  • Florenci Serras
  • Cristina Chamizo
  • Pedro L Fernandez
  • Anna Lluch
  • Jessica Furriol
  • Dylan J M Bergen
  • Rosanna Paciucci
  • Pablo Menendez
  • Sonia Servitja
  • Abul B M M K Islam
  • Irene González
  • Cristina Ruiz
  • Ryoichiro Kageyama
  • Jun Hatakeyama
  • Ritsuko Shimizu
  • Alba Jené-Sanz
  • Jordi Villà-Freixa
  • Roger R Gomis
  • Maria Martínez-Iniesta
  • Marty W Mayo
  • Laura Lopez
  • Ferran Torres
  • Alberto Villanueva
  • Montserrat Andreu
  • Vanessa Fernández-Majada
  • Mari Carmen Mulero
  • Monica Morales

Detail Information

Publications13

  1. pmc Prostate tumor OVerexpressed-1 (PTOV1) down-regulates HES1 and HEY1 notch targets genes and promotes prostate cancer progression
    Lide Alaña
    Research Unit in Biomedicine and Translational Oncology, Vall d Hebron Research Institute, PG, Vall d Hebron 119 129, Barcelona 08035, Spain
    Mol Cancer 13:74. 2014
    ..Here we report its interaction with the Notch pathway and its involvement in PC progression...
  2. pmc The Notch/Hes1 pathway sustains NF-κB activation through CYLD repression in T cell leukemia
    Lluis Espinosa
    Cancer Research Program, Institut Municipal d Investigacions Mediques, IMIM, Hospital del Mar, 08003 Barcelona, Spain
    Cancer Cell 18:268-81. 2010
    ....
  3. pmc Hes repressors are essential regulators of hematopoietic stem cell development downstream of Notch signaling
    Jordi Guiu
    Program in Cancer Research, Hospital del Mar Medical Research Institute, IMIM, Barcelona Biomedical Research Park, 08003 Barcelona, Spain
    J Exp Med 210:71-84. 2013
    ....
  4. doi request reprint The Notch pathway in hematopoietic stem cells
    Anna Bigas
    Program in Cancer Research Institut Mar Investigacions Mèdiques IMIM, Hospital del Mar, Parc de Recerca Biomedica de Barcelona, Dr Aiguader 88, 08003, Barcelona, Spain
    Curr Top Microbiol Immunol 360:1-18. 2012
    ..In the following sections, we will review what is known about the role of Notch in HSC establishment and hematopoietic cell lineage specification...
  5. pmc Hematopoietic stem cell development requires transient Wnt/β-catenin activity
    Cristina Ruiz-Herguido
    Program in Cancer Research, Institut Hospital del Mar d Investigacions Mèdiques, Parc de Recerca Biomedica de Barcelona, 08003 Barcelona, Spain
    J Exp Med 209:1457-68. 2012
    ..Together, those findings indicate that Wnt/β-catenin activity is needed for the emergence but not the maintenance of HSCs in mouse embryos...
  6. doi request reprint The Notch pathway in the developing hematopoietic system
    Anna Bigas
    Program in Cancer Research, IMIM Hospital del Mar, Barcelona, Spain
    Int J Dev Biol 54:1175-88. 2010
    ..Here, we will review the work from recent years showing how Notch participates in the embryonic development of hematopoiesis in the mouse, but also in other organisms such as chick, zebrafish and flies...
  7. doi request reprint Active nuclear IKK correlates with metastatic risk in cutaneous squamous cell carcinoma
    Agusti Toll
    Department of Dermatology, Hospital del Mar, Parc de Salut Mar, Barcelona, Spain
    Arch Dermatol Res 307:721-9. 2015
    ..Our results indicate that nuclear active IKK is a robust biomarker to predict cSCC outcome, and suggest the possibility of targeting IKK activity as a future therapy for treating metastatic cSCC...
  8. pmc Identification of Cdca7 as a novel Notch transcriptional target involved in hematopoietic stem cell emergence
    Jordi Guiu
    Program de Recerca en Càncer, Institut Hospital del Mar d Investigacions Mèdiques, Parc de Recerca Biomedica de Barcelona, 08003 Barcelona, Spain
    J Exp Med 211:2411-23. 2014
    ..Thus, our study identifies Cdca7 as an evolutionary conserved Notch target involved in HSC emergence. ..
  9. doi request reprint Notch1 Pathway Activation Results from the Epigenetic Abrogation of Notch-Related MicroRNAs in Mycosis Fungoides
    Fernando Gallardo
    Servei de Dermatologia, Hospital del Mar, Universitat Autonoma de Barcelona, Barcelona, Spain
    J Invest Dermatol 135:3144-52. 2015
    ..Our study deciphers an epigenetic mechanism regulating the Notch pathway in (MF) that might contribute to the future design of more specific therapeutic strategies. ..
  10. pmc Deficiency in p53 is required for doxorubicin induced transcriptional activation of NF-кB target genes in human breast cancer
    Alba Dalmases
    Cancer Research Program, IMIM Hospital del Mar Research Institute, Barcelona, Spain
    Oncotarget 5:196-210. 2014
    ..This study supports that p53 deficiency is necessary for a doxorubicin driven NF-кB-response that limits doxorubicin cytotoxicity in breast cancer and is linked to an aggressive clinical behavior...
  11. doi request reprint A truncated form of IKKα is responsible for specific nuclear IKK activity in colorectal cancer
    Pol Margalef
    Institut Municipal d Investigacions Mediques, Institut Hospital del Mar d Investigacions Mèdiques, Parc de Recerca Biomedica de Barcelona, Barcelona 08003, Spain
    Cell Rep 2:840-54. 2012
    ..Our findings identify a potentially druggable target for treating patients with advance refractory CRC...
  12. pmc Inhibition of specific NF-κB activity contributes to the tumor suppressor function of 14-3-3σ in breast cancer
    Julia Inglés-Esteve
    Cancer Research Program, IMIM Hospital del Mar Research Institute, Barcelona, Spain
    PLoS ONE 7:e38347. 2012
    ..Our findings identify a genetic signature that is important for breast cancer prognosis and for future personalized treatments based on NF-κB targeting...