Benoit R Gauthier

Summary

Country: Spain

Publications

  1. pmc PDX1 deficiency causes mitochondrial dysfunction and defective insulin secretion through TFAM suppression
    Benoit R Gauthier
    Department of Cell Physiology and Metabolism, University of Geneva, Geneva, Switzerland
    Cell Metab 10:110-8. 2009
  2. ncbi request reprint A Simple High Efficiency Intra-Islet Transduction Protocol Using Lentiviral Vectors
    Carmen Maria Jimenez-Moreno
    Pancreatic Islet Development and Regeneration Unit, Department of Stem Cells, CABIMER Andalusian Center for Molecular Biology and Regenerative Medicine, Avenida Américo Vespucio, Parque Científico y Tecnológico Cartuja 93, 41092 Sevilla, Spain
    Curr Gene Ther 15:436-46. 2015
  3. ncbi request reprint Oligonucleotide microarray analysis reveals PDX1 as an essential regulator of mitochondrial metabolism in rat islets
    Benoit R Gauthier
    Department of Cell Physiology and Metabolism and Genomics Platform, National Center of Competence in Research Frontiers in Genetics, University of Geneva, 1211 Geneva 4, Switzerland
    J Biol Chem 279:31121-30. 2004
  4. ncbi request reprint The diabetes-linked transcription factor Pax4 is expressed in human pancreatic islets and is activated by mitogens and GLP-1
    Thierry Brun
    Department of Cell Physiology and Metabolism, University Medical Center, 1211 Geneva 4, Switzerland
    Hum Mol Genet 17:478-89. 2008
  5. pmc Hepatic nuclear factor 1alpha (HNF1alpha) dysfunction down-regulates X-box-binding protein 1 (XBP1) and sensitizes beta-cells to endoplasmic reticulum stress
    Clare L Kirkpatrick
    Department of Cell Physiology and Metabolism, Centre Medical Universitaire, Universite de Geneve, 1 rue Michel Servet, 1211 Geneve 4, Switzerland
    J Biol Chem 286:32300-12. 2011
  6. pmc PAX4 preserves endoplasmic reticulum integrity preventing beta cell degeneration in a mouse model of type 1 diabetes mellitus
    Jose Manuel Mellado-Gil
    Pancreatic Islet Development and Regeneration Unit, Department of Stem Cells, Andalusian Center for Molecular Biology and Regenerative Medicine CABIMER, Avda Americo Vespucio, Parque Científico y Tecnológico Cartuja 93, 41092, Seville, Spain
    Diabetologia 59:755-65. 2016
  7. ncbi request reprint Synaptotagmin VII splice variants alpha, beta, and delta are expressed in pancreatic beta-cells and regulate insulin exocytosis
    Benoit R Gauthier
    Department of Cell Physiology and Metabolism, University Medical Center, 1211 Geneva 4, Switzerland
    FASEB J 22:194-206. 2008
  8. pmc The diabetes-linked transcription factor PAX4 promotes {beta}-cell proliferation and survival in rat and human islets
    Thierry Brun
    Department of Cell Physiology and Metabolism, University Medical Center, Geneva, Switzerland
    J Cell Biol 167:1123-35. 2004
  9. pmc PAX4 Defines an Expandable β-Cell Subpopulation in the Adult Pancreatic Islet
    Petra I Lorenzo
    Pancreatic Islet Development and Regeneration Unit, Department of Stem Cells, CABIMER Andalusian Center for Molecular Biology and Regenerative Medicine, Seville, Spain
    Sci Rep 5:15672. 2015
  10. pmc Cx36 makes channels coupling human pancreatic beta-cells, and correlates with insulin expression
    Veronique Serre-Beinier
    Surgical Research Unit, Department of Surgery, Geneva University Hospitals, Geneva, Switzerland
    Hum Mol Genet 18:428-39. 2009

Collaborators

Detail Information

Publications19

  1. pmc PDX1 deficiency causes mitochondrial dysfunction and defective insulin secretion through TFAM suppression
    Benoit R Gauthier
    Department of Cell Physiology and Metabolism, University of Geneva, Geneva, Switzerland
    Cell Metab 10:110-8. 2009
    ..Thus, the genetic control by the beta cell-specific factor Pdx1 of the ubiquitous gene TFAM maintains beta cell mtDNA vital for ATP production and normal GSIS...
  2. ncbi request reprint A Simple High Efficiency Intra-Islet Transduction Protocol Using Lentiviral Vectors
    Carmen Maria Jimenez-Moreno
    Pancreatic Islet Development and Regeneration Unit, Department of Stem Cells, CABIMER Andalusian Center for Molecular Biology and Regenerative Medicine, Avenida Américo Vespucio, Parque Científico y Tecnológico Cartuja 93, 41092 Sevilla, Spain
    Curr Gene Ther 15:436-46. 2015
    ..Our protocol will facilitate to fully determine the potential of gene expression modulation of therapeutically promising targets in entire pancreatic islets for xenotransplantation purposes. ..
  3. ncbi request reprint Oligonucleotide microarray analysis reveals PDX1 as an essential regulator of mitochondrial metabolism in rat islets
    Benoit R Gauthier
    Department of Cell Physiology and Metabolism and Genomics Platform, National Center of Competence in Research Frontiers in Genetics, University of Geneva, 1211 Geneva 4, Switzerland
    J Biol Chem 279:31121-30. 2004
    ..In conclusion, loss of PDX1 function alters expression of mitochondrially encoded genes through regulation of TFAM leading to impaired insulin secretion...
  4. ncbi request reprint The diabetes-linked transcription factor Pax4 is expressed in human pancreatic islets and is activated by mitogens and GLP-1
    Thierry Brun
    Department of Cell Physiology and Metabolism, University Medical Center, 1211 Geneva 4, Switzerland
    Hum Mol Genet 17:478-89. 2008
    ..The latter highlights fundamental differences between human and rodent islet physiology and emphasizes the importance of validating results obtained with animal models in human tissues...
  5. pmc Hepatic nuclear factor 1alpha (HNF1alpha) dysfunction down-regulates X-box-binding protein 1 (XBP1) and sensitizes beta-cells to endoplasmic reticulum stress
    Clare L Kirkpatrick
    Department of Cell Physiology and Metabolism, Centre Medical Universitaire, Universite de Geneve, 1 rue Michel Servet, 1211 Geneve 4, Switzerland
    J Biol Chem 286:32300-12. 2011
    ..Rat insulin 2 promoter-DN HNF1α mouse islets express lower levels of BiP mRNA, synthesize less insulin, and are sensitized to ER stress relative to matched control mouse islets, suggesting that this mechanism is also operating in vivo...
  6. pmc PAX4 preserves endoplasmic reticulum integrity preventing beta cell degeneration in a mouse model of type 1 diabetes mellitus
    Jose Manuel Mellado-Gil
    Pancreatic Islet Development and Regeneration Unit, Department of Stem Cells, Andalusian Center for Molecular Biology and Regenerative Medicine CABIMER, Avda Americo Vespucio, Parque Científico y Tecnológico Cartuja 93, 41092, Seville, Spain
    Diabetologia 59:755-65. 2016
    ..1 mouse model background and to characterise putative cellular mechanisms associated with preserved BCM...
  7. ncbi request reprint Synaptotagmin VII splice variants alpha, beta, and delta are expressed in pancreatic beta-cells and regulate insulin exocytosis
    Benoit R Gauthier
    Department of Cell Physiology and Metabolism, University Medical Center, 1211 Geneva 4, Switzerland
    FASEB J 22:194-206. 2008
    ..Our results demonstrate that SYTVII is expressed on insulin granules and that only SYTVII alpha is implicated in exocytosis under physiological conditions...
  8. pmc The diabetes-linked transcription factor PAX4 promotes {beta}-cell proliferation and survival in rat and human islets
    Thierry Brun
    Department of Cell Physiology and Metabolism, University Medical Center, Geneva, Switzerland
    J Cell Biol 167:1123-35. 2004
    ..We propose that Pax4 is implicated in beta-cell plasticity through the activation of c-myc and potentially protected from apoptosis through Bcl-xL gene expression...
  9. pmc PAX4 Defines an Expandable β-Cell Subpopulation in the Adult Pancreatic Islet
    Petra I Lorenzo
    Pancreatic Islet Development and Regeneration Unit, Department of Stem Cells, CABIMER Andalusian Center for Molecular Biology and Regenerative Medicine, Seville, Spain
    Sci Rep 5:15672. 2015
    ..Under stress conditions, GFP(+) cells were more resistant to apoptosis than their GFP(-) counterparts. Our data suggest PAX4 defines an expandable β-cell sub population within adult islets. ..
  10. pmc Cx36 makes channels coupling human pancreatic beta-cells, and correlates with insulin expression
    Veronique Serre-Beinier
    Surgical Research Unit, Department of Surgery, Geneva University Hospitals, Geneva, Switzerland
    Hum Mol Genet 18:428-39. 2009
    ..The data show that Cx36 is a native protein of human pancreatic islets, which mediates the coupling of the insulin-producing beta-cells, and contributes to control beta-cell function by modulating gene expression...
  11. pmc Immunohistochemical assessment of Pax8 expression during pancreatic islet development and in human neuroendocrine tumors
    Petra I Lorenzo
    Pancreatic Islet Development and Regeneration Unit, Department of Stem Cells, Andalusian Center for Molecular Biology and Regenerative Medicine, Seville, Spain
    Histochem Cell Biol 136:595-607. 2011
    ..In conclusion, Pax8 is not expressed in the pancreas and cast doubts on the value of Pax8 as a pancreatic neuroendocrine tumor marker...
  12. pmc Transcriptional response of pancreatic beta cells to metabolic stimulation: large scale identification of immediate-early and secondary response genes
    Dominique A Glauser
    Fondation pour Recherches Medicales, University of Geneva, Geneva, Switzerland
    BMC Mol Biol 8:54. 2007
    ..The identity of these target genes has not been determined, and the sequence of events occurring during beta cell adaptation is still unclear...
  13. ncbi request reprint Targeting pancreatic expressed PAX genes for the treatment of diabetes mellitus and pancreatic neuroendocrine tumors
    Alejandro Martín-Montalvo
    a Department of Stem Cells, CABIMER Andalusian Center for Molecular Biology and Regenerative Medicine, Avenida Américo Vespucio, Pancreatic Islet Development and Regeneration Unit Laboratory of Aging Biology PIDRU LAB, Sevilla, Spain
    Expert Opin Ther Targets 21:77-89. 2017
    ..Expert opinion: Based on the current literature, we propose that future interventions to treat pancreatic neuroendocrine tumors and diabetes mellitus could be developed via the modulation of PAX4 and/or PAX6 regulated pathways...
  14. pmc In vivo conditional Pax4 overexpression in mature islet β-cells prevents stress-induced hyperglycemia in mice
    Kai Hui Hu He
    Department of Cell Physiology and Metabolism, University of Geneva, Geneva, Switzerland
    Diabetes 60:1705-15. 2011
    ....
  15. doi request reprint A focus on the role of Pax4 in mature pancreatic islet beta-cell expansion and survival in health and disease
    Thierry Brun
    Department of Cell Physiology and Metabolism, University Medical Centre, 1211 Geneva 4, Switzerland
    J Mol Endocrinol 40:37-45. 2008
    ..This review summarizes promising new published results supporting the important function of Pax4 in mature islet beta-cell physiology and its contribution to pathophysiology when deregulated...
  16. ncbi request reprint Experimental models of transcription factor-associated maturity-onset diabetes of the young
    Haiyan Wang
    Department of Internal Medicine, Division of Clinical Biochemistry, University Medical Centre, Geneva, Switzerland
    Diabetes 51:S333-42. 2002
    ..The presented experimental models are important tools for the elucidation of the beta-cell pathogenesis in MODY syndromes...
  17. ncbi request reprint CD14 is an acute-phase protein
    Sylvette Bas
    Division of Rheumatology, Department of Internal Medicine, University Hospital, Geneva, Switzerland
    J Immunol 172:4470-9. 2004
    ..Liver levels of CD14 mRNA increased in IL-6(+/+), but not in IL-6(-/-) mice. These results indicate that sCD14 can be considered as a type 2 APP...