X Filella

Summary

Country: Spain

Publications

  1. ncbi request reprint Analysis of type T1 and T2 cytokines in patients with prostate cancer
    X Filella
    Unit for Cancer Research, Department of Clinical Biochemistry, Institut d Investigacions Biomediques August Pi i Sunyer, Hospital Clinic, Barcelona, Spain
    Prostate 44:271-4. 2000
  2. ncbi request reprint Prospective evaluation of tumor markers (c-erbB-2 oncoprotein, CEA and CA 15.3) in patients with locoregional breast cancer
    R Molina
    Laboratory of Clinical Biochemistry, Hospital Clinic, Medical School, Villarroel 170, Barcelona 08036, Spain
    Anticancer Res 23:1043-50. 2003
  3. ncbi request reprint Circulating levels of Th1/Th2 cytokines in patients with primary Sjögren's syndrome: correlation with clinical and immunological features
    M Garcíc-Carrasco
    Systemic Autoimmune Diseases Unit, Institut d Investigacions Biomediques August Pi i Sunyer, Hospital Clinic, School of Medicine, University of Barcelona, Spain
    Clin Exp Rheumatol 19:411-5. 2001
  4. ncbi request reprint Influence of AFP, CEA and PSA on the in vitro production of cytokines
    X Filella
    Unit for Cancer Research, Department of Clinical Biochemistry, Hospital Clinic, Barcelona, Spain
    Tumour Biol 22:67-71. 2001
  5. ncbi request reprint Evaluation of a multivariate prostate-specific antigen and percentage of free prostate-specific antigen logistic regression model in the diagnosis of prostate cancer
    X Filella
    Department of Clinical Biochemistry Unit for Cancer Research, Institut d Investigacions Biomediques August Pi i Sunyer, Hospital Clinic, Barcelona, Spain
    Tumour Biol 20:312-8. 1999
  6. ncbi request reprint Measurement of complexed PSA in the differential diagnosis between prostate cancer and benign prostate hyperplasia
    X Filella
    Unit for Cancer Research, Department of Clinical Biochemistry, Institut d Investigacions Biomediques August Pi i Sunyer, Hospital Clinic, Barcelona, Spain
    Prostate 42:181-5. 2000
  7. ncbi request reprint TAG-72, CA 19.9 and CEA as tumor markers in gastric cancer
    X Filella
    Department of Clinical Biochemistry, , Barcelona, Spain
    Acta Oncol 33:747-51. 1994
  8. ncbi request reprint Serum HER2 extracellular domain predicts an aggressive clinical outcome and biological PSA response in hormone-independent prostate cancer patients treated with docetaxel
    J Domingo-Domenech
    Department of Medical Oncology and Laboratory of Experimental Oncology, Institut Clinic de Malalties Hemato Oncologiques, Barcelona, Spain
    Ann Oncol 19:269-75. 2008
  9. pmc Utility of C-erbB-2 in tissue and in serum in the early diagnosis of recurrence in breast cancer patients: comparison with carcinoembryonic antigen and CA 15.3
    R Molina
    Laboratory of Biochemistry Unit for Cancer Research, , School of Medicine, Barcelona, Spain
    Br J Cancer 74:1126-31. 1996
  10. ncbi request reprint Impaired production of interleukin 6 and tumour necrosis factor alpha in whole blood cell cultures of patients with multiple myeloma
    X Filella
    Department of Clinical Biochemistry Unit for Cancer Research, Hospital Clinic, Barcelona, Catalonia, Spain
    Cytokine 10:993-6. 1998

Collaborators

Detail Information

Publications33

  1. ncbi request reprint Analysis of type T1 and T2 cytokines in patients with prostate cancer
    X Filella
    Unit for Cancer Research, Department of Clinical Biochemistry, Institut d Investigacions Biomediques August Pi i Sunyer, Hospital Clinic, Barcelona, Spain
    Prostate 44:271-4. 2000
    ..It has been proposed that a dysregulation in the balance between type T1 (IL-2, IFN-gamma) and type T2 (IL-4, IL-10) cytokines may be implicated in the development of cancer...
  2. ncbi request reprint Prospective evaluation of tumor markers (c-erbB-2 oncoprotein, CEA and CA 15.3) in patients with locoregional breast cancer
    R Molina
    Laboratory of Clinical Biochemistry, Hospital Clinic, Medical School, Villarroel 170, Barcelona 08036, Spain
    Anticancer Res 23:1043-50. 2003
    ..3, c-erbB-2, PgR, adjuvant treatment, p53 (345 patients) or c-erbB-2 in tissue are independent prognostic factors. In summary, tumor markers are a useful, inexpensive and reproducible tool for prognosis in breast cancer...
  3. ncbi request reprint Circulating levels of Th1/Th2 cytokines in patients with primary Sjögren's syndrome: correlation with clinical and immunological features
    M Garcíc-Carrasco
    Systemic Autoimmune Diseases Unit, Institut d Investigacions Biomediques August Pi i Sunyer, Hospital Clinic, School of Medicine, University of Barcelona, Spain
    Clin Exp Rheumatol 19:411-5. 2001
    ..To analyse the circulating levels of Th1 and Th2 cytokines in patients with primary Sjögren's syndrome (SS), as well as to investigate their association with clinical and immunological manifestations...
  4. ncbi request reprint Influence of AFP, CEA and PSA on the in vitro production of cytokines
    X Filella
    Unit for Cancer Research, Department of Clinical Biochemistry, Hospital Clinic, Barcelona, Spain
    Tumour Biol 22:67-71. 2001
    ..001) and TNF-alpha (p = 0.002), while PSA significantly decreased IL-1beta (p <0.001), IL-6 (p = 0.031) and TNF-alpha (p <0.0001) production. These results suggest a possible role of CEA and PSA in the production of these cytokines...
  5. ncbi request reprint Evaluation of a multivariate prostate-specific antigen and percentage of free prostate-specific antigen logistic regression model in the diagnosis of prostate cancer
    X Filella
    Department of Clinical Biochemistry Unit for Cancer Research, Institut d Investigacions Biomediques August Pi i Sunyer, Hospital Clinic, Barcelona, Spain
    Tumour Biol 20:312-8. 1999
    ..The posterior construction of a nomogram based on the data obtained greatly facilitates the application of the logistic regression model...
  6. ncbi request reprint Measurement of complexed PSA in the differential diagnosis between prostate cancer and benign prostate hyperplasia
    X Filella
    Unit for Cancer Research, Department of Clinical Biochemistry, Institut d Investigacions Biomediques August Pi i Sunyer, Hospital Clinic, Barcelona, Spain
    Prostate 42:181-5. 2000
    ..The aim of this study was to evaluate the usefulness of complexed PSA in the differential diagnosis between benign prostate hyperplasia (BPH) and prostate cancer...
  7. ncbi request reprint TAG-72, CA 19.9 and CEA as tumor markers in gastric cancer
    X Filella
    Department of Clinical Biochemistry, , Barcelona, Spain
    Acta Oncol 33:747-51. 1994
    ..The results suggest that the combination of TAG-72 and CA 19.9 may be useful in the post surgical management of patients with gastric cancer...
  8. ncbi request reprint Serum HER2 extracellular domain predicts an aggressive clinical outcome and biological PSA response in hormone-independent prostate cancer patients treated with docetaxel
    J Domingo-Domenech
    Department of Medical Oncology and Laboratory of Experimental Oncology, Institut Clinic de Malalties Hemato Oncologiques, Barcelona, Spain
    Ann Oncol 19:269-75. 2008
    ..Human epidermal growth factor receptor 2 (HER2) overexpression has been linked to hormone-independent prostate cancer (HIPC) progression. Its clinical value and correlation with therapy is not defined...
  9. pmc Utility of C-erbB-2 in tissue and in serum in the early diagnosis of recurrence in breast cancer patients: comparison with carcinoembryonic antigen and CA 15.3
    R Molina
    Laboratory of Biochemistry Unit for Cancer Research, , School of Medicine, Barcelona, Spain
    Br J Cancer 74:1126-31. 1996
    ..Using all three markers simultaneously it is possible to increase the sensitivity in the early diagnosis of recurrence by 11.2%...
  10. ncbi request reprint Impaired production of interleukin 6 and tumour necrosis factor alpha in whole blood cell cultures of patients with multiple myeloma
    X Filella
    Department of Clinical Biochemistry Unit for Cancer Research, Hospital Clinic, Barcelona, Catalonia, Spain
    Cytokine 10:993-6. 1998
    ..001 for IL-6 and TNF-alpha at 24 and 48 h). The impaired IL-6 and TNF-alpha production in patients with symptomatic MM is probably due to a tumour-related immunosuppressive status...
  11. ncbi request reprint Free to complexed PSA ratio in differentiating benign prostate hyperplasia from prostate cancer
    X Filella
    Department of Clinical Biochemistry, Institut d Investigacions Biomediques August Pi i Sunyer, Hospital Clinic, Barcelona, Spain
    Anticancer Res 21:3717-20. 2001
    ..The aim of our study was to assess the diagnostic potential of PSA and the PSA fractions in the diagnosis of benign prostate hyperplasia (BPH) and prostate cancer...
  12. ncbi request reprint TH1/TH2 cytokine release pattern during in vivo cytomegalovirus disease in solid organ transplantation
    C Cervera
    Infectious Diseases Service, Hospital Clinic, IDIBAPS, University of Barcelona, Barcelona, Spain
    Transplant Proc 39:2233-5. 2007
    ..The release of pro- and anti-inflammatory cytokines could be one of the responsible factors...
  13. ncbi request reprint Relationship of oncogenes (sFas, Bcl-2) and cytokines (IL-10, alfa-TNF) with the activity of systemic lupus erythematosus
    C Miret
    Systemic Autoimmune Disease Unit, Hospital Clinic, Barcelona, Spain
    Anticancer Res 21:3053-9. 2001
    ..These alterations may interfere with the apoptotic process, promoting lymphocyte hyperactivity secondary to increased cytokine levels, and causing the characteristic features of SLE...
  14. doi request reprint Variability of assay methods for total and free PSA after WHO standardization
    L Foj
    Department of Biochemistry and Molecular Genetics CDB, Hospital Clinic, IDIBAPS, C Villarroel, 170, 08036, Barcelona, Catalonia, Spain
    Tumour Biol 35:1867-73. 2014
    ..We have shown significant discordances between assays included in this study despite advances in standardization conducted in the last years. Further harmonization efforts are required in order to obtain a complete clinical concordance. ..
  15. ncbi request reprint Interleukin-4, interleukin-10, and granulocyte-macrophage colony stimulating factor in second-trimester serum from women with preeclampsia
    E Gratacos
    Departament d Obstetricia i Ginecologia, Hospital Clinic, Universitat de Barcelona, Catalunya, Spain
    Obstet Gynecol 92:849-53. 1998
    ....
  16. ncbi request reprint S-100beta and MIA in advanced melanoma in relation to prognostic factors
    J M Auge
    Oncobiology Unit, Laboratory of Biochemistry, IDIBAPS, Hospital Clinic, Medical School, Barcelona, Spain
    Anticancer Res 25:1779-82. 2005
    ..MIA was related to the same metastases locations but without statistical significance. In summary, both S100 and ML4 are useful markers related to prognostic factors, being more effective when used in combination...
  17. ncbi request reprint Tumor markers (CEA, CA 125, CYFRA 21-1, SCC and NSE) in patients with non-small cell lung cancer as an aid in histological diagnosis and prognosis. Comparison with the main clinical and pathological prognostic factors
    R Molina
    Laboratory of Clinical Biochemistry, Unit for Cancer Research, Hospital Clinic, Barcelona, Spain
    Tumour Biol 24:209-18. 2003
    ..Eighty-five percent of the patients with SCC levels >2 ng/ml had squamous tumors. Likewise, CA 125 levels <60 U/ml or CEA <10 ng/ml excluded adenocarcinoma or LCLC with a probability of 82 and 91%, respectively...
  18. doi request reprint Cervical length and gestational age at admission as predictors of intra-amniotic inflammation in preterm labor with intact membranes
    M Palacio
    Department of Maternal Fetal Medicine, Institute Clinic of Gynecology, Obstetrics and Neonatology, Barcelona, Spain
    Ultrasound Obstet Gynecol 34:441-7. 2009
    ..To evaluate cervical length and gestational age as predictors of intra-amniotic inflammation in patients admitted because of preterm labor and intact membranes...
  19. ncbi request reprint Correlation of serum interleukin-6 (IL-6) levels and clinical outcome in hormone-independent (HI) prostate cancer (PC) patients (PTS) treated with docetaxel
    L Visa
    Medical Oncology, Laboratory Traslational Oncology, Hospital Clinic Barcelona, Barcelona, Spain Medical Oncology Deparment, Barcelona, Spain Medical Oncology Deparment, Barcelona, Spain Medical Oncology, Laboratory Translational Oncology, Barcelona, Spain Biochemistry Department, Hospital Clinic Barcelona, Barcelona, Spain Medical Oncology Department, Barcelona, Spain Medical Oncology Department, Hospital Clinic Barcelona, Barcelona, Spain Hospital Clínic, Barcelona, Spain
    J Clin Oncol 27:e16044. 2009
    ..We previously reported preliminary data on the correlation of serum IL-6 and D response in metastatic HI PC pts. We present here a larger group of pts tested to asses the clinical relevance of IL-6 in these pts...
  20. ncbi request reprint Prospective evaluation of CEA and CA 15.3 in patients with locoregional breast cancer
    R Molina
    Laboratory of Clinical Biochemistry Unit for Cancer Research, Hospital Clinic, Medical School, Villarroel 170, Barcelona 08036, Spain
    Anticancer Res 23:1035-41. 2003
    ..CA 15.3 was useful for prognosis (OS) in node-negative patients. In summary, tumor markers are useful tools in the prognostic evaluation of patients with breast cancer...
  21. ncbi request reprint Increased tumour necrosis factor-alpha plasma levels during moderate-intensity exercise in COPD patients
    R A Rabinovich
    Servei de Pneumologia ICPCT, Higher Scientific Research Council, Hospital Clinic, Faculty of Medicine, August Pi i Sunyer Biomedical Research Institute, Barcelona, Spain
    Eur Respir J 21:789-94. 2003
    ....
  22. ncbi request reprint Acute phase response in laparoscopic and open colectomy in colon cancer: randomized study
    S Delgado
    Department of General and Digestive Surgery, Institute of Digestive Diseases (IMD, Hospital Clinic, University of Barcelona, Spain
    Dis Colon Rectum 44:638-46. 2001
    ..CONCLUSIONS: The results obtained in this randomized, prospective study suggest that acute phase systemic response is attenuated in patients undergoing laparoscopic-assisted colectomy in comparison with patients receiving open colectomy...
  23. ncbi request reprint Vascular endothelial growth factor serum concentrations in hypercholesterolemic patients
    J Trape
    Department of Laboratory Medicine, Hospital de Sant Joan de Deu, Althaia Xarxa Assistencial de Manresa, Barcelona, Spain
    Scand J Clin Lab Invest 66:261-7. 2006
    ....
  24. doi request reprint The clinical value of biomarkers in respiratory complications in hematopoietic SCT
    C M Lucena
    Department of Pneumology, Hospital Clinic i Provincial, Barcelona, Spain
    Bone Marrow Transplant . 2016
    ..They may have utility in the assessment of the severity of RC and in suspecting a viral etiology.Bone Marrow Transplantation advance online publication, 31 October 2016; doi:10.1038/bmt.2016.280...
  25. ncbi request reprint Serum osteoprotegerin and its ligand in Paget's disease of bone: relationship to disease activity and effect of treatment with bisphosphonates
    L Alvarez
    Hospital Clinic, University of Barcelona and Institut d Investigacions Biomèdiques August Pi i Sunyer, Barcelona, Spain
    Arthritis Rheum 48:824-8. 2003
    ....
  26. ncbi request reprint Prospective evaluation of procalcitonin in adults with non-neutropenic fever after allogeneic hematopoietic stem cell transplantation
    M Ortega
    Infectious Diseases Unit, Hospital Clinic, IDIBAPS, University of Barcelona, Barcelona, Spain
    Bone Marrow Transplant 37:499-502. 2006
    ..5 (+/- 3.4) in possible IFI and 1.5 (+/- 0.9) in infections other than IFI. Therefore, we could conclude that during the non-neutropenic phases of allogeneic HSCT, a high PCT value is associated significantly with IA...
  27. ncbi request reprint Endothelial cell activation in muscle biopsy samples is related to clinical severity in human cerebral malaria
    F Garcia
    Infectious Diseases Unit, Hospital Clinic, 08036, Barcelona, Spain
    J Infect Dis 179:475-83. 1999
    ..These data suggest that skeletal muscle biopsy could be a useful model for the study of the pathogenesis of malaria in vivo...
  28. ncbi request reprint BTA TRAK urine test increases the efficacy of cytology in the diagnosis of low-grade transitional cell carcinoma of the bladder
    R Gibanel
    Department of Urology and Renal Transplantation, Hospital Clinic, Barcelona, Spain
    Anticancer Res 22:1157-60. 2002
    ..Among urinary tumor markers we studied the utility of the BTA TRAK assay to diagnose transitional cell carcinoma of the bladder in highly suspiscious patients, in comparison to urine cytology...
  29. ncbi request reprint Effect of proinflammatory cytokines (IL-6, TNF-alpha, IL-1beta) on hemodynamic performance during orthotopic liver transplantation
    J Arranz
    Liver Transplant Unit, Research Unit, University Hospital Clinic Barcelona, University Hospital NS de Candelaria, Tenerife, Spain
    Transplant Proc 35:1884-7. 2003
    ..The aim of the present study was to analyze the association between IL-6, TNF-alpha, and IL-1beta and systemic vascular resistance during the phases of liver transplantation...
  30. ncbi request reprint Systemic inflammatory response after bronchoalveolar lavage in critically ill patients
    T T Bauer
    Institute of Pneumology and Thoracic Surgery, Hospital Clinic de Barcelona, Spain
    Eur Respir J 17:274-80. 2001
    ..The potential cytokine increase is probably too small, in relation to the pre-existing inflammatory response, to yield clinical significance in this population otherwise antibiotic therapy may have been protective...
  31. ncbi request reprint Bronchial inflammation and colonization in patients with clinically stable bronchiectasis
    J Angrill
    Servei de Pneumologia, , Spain
    Am J Respir Crit Care Med 164:1628-32. 2001
    ....
  32. ncbi request reprint [Cytokines value as a sepsis and mortality predictor in elderly patients with fever]
    L Marti
    Servicio de Infecciones Hospital Clínic Barcelona Spain
    Med Clin (Barc) 121:361-6. 2003
    ..However, there is not sufficient data about their usefulness in elderly patients with acute septic pathology. Our objective was to identify the cytokines related to bacteremia and those that predicted a bad prognosis in elderly patients...
  33. doi request reprint Markers of treatment failure in hospitalised community acquired pneumonia
    R Menendez
    Servicio de Neumologia, Hospital Universitario La Fe, Avda de Campanar 21, 46009 Valencia, Spain
    Thorax 63:447-52. 2008
    ..We evaluated the systemic cytokine profile (tumour necrosis factor alpha, interleukin (IL)1, IL6, IL8 and IL10), C reactive protein (CRP) and procalcitonin (PCT) in patients with CAP who had treatment failure...