Javier Fernandez

Summary

Country: Spain

Publications

  1. doi request reprint Clinical course and short-term mortality of cirrhotic patients with infections other than spontaneous bacterial peritonitis
    Javier Fernandez
    Liver Unit, Hospital Clinic, Barcelona, Spain
    Liver Int . 2016
  2. doi request reprint Management of bacterial infections in cirrhosis
    Javier Fernandez
    Liver Unit, IMDiM, Hospital Clinic, Universidad de Barcelona, IDIBAPS and Ciberehd, Barcelona, Spain
    J Hepatol 56:S1-12. 2012
  3. doi request reprint Prevalence and risk factors of infections by multiresistant bacteria in cirrhosis: a prospective study
    Javier Fernandez
    Liver Unit, Hospital Clinic, University of Barcelona, Barcelona, Spain
    Hepatology 55:1551-61. 2012
  4. ncbi request reprint [Adrenal insufficiency in cirrhosis]
    Javier Fernandez
    IMDiM, IDIBAPS, Hospital Clinic, Universidad de Barcelona, CIBERehd, Barcelona, Espana
    Gastroenterol Hepatol 31:606-11. 2008
  5. ncbi request reprint Adrenal insufficiency in patients with cirrhosis and septic shock: Effect of treatment with hydrocortisone on survival
    Javier Fernandez
    Liver Unit, Department of Surgery and Centro de Investigaciones Biomédicas Esther Koplowitz, IMDiM, IDIBAPS, Hospital Clinic, University of Barcelona, Spain
    Hepatology 44:1288-95. 2006
  6. ncbi request reprint A randomized unblinded pilot study comparing albumin versus hydroxyethyl starch in spontaneous bacterial peritonitis
    Javier Fernandez
    Liver Unit, IMDM and IDIBAPS, Hospital Clinic, University of Barcelona, Spain
    Hepatology 42:627-34. 2005
  7. ncbi request reprint Effect of intravenous albumin on systemic and hepatic hemodynamics and vasoactive neurohormonal systems in patients with cirrhosis and spontaneous bacterial peritonitis
    Javier Fernandez
    Liver Unit, IMD, IDIBAPS, Hospital Clinic, University of Barcelona, Barcelona, Spain
    J Hepatol 41:384-90. 2004
  8. doi request reprint Type-1 hepatorenal syndrome associated with infections in cirrhosis: natural history, outcome of kidney function, and survival
    Rogelio Barreto
    Liver Unit, Hospital Clinic, University of Barcelona, Barcelona, Catalunya, Spain Institut d Investigacions Biomèdiques August Pi Sunyer IDIBAPS, Barcelona, Spain Centro de Investigación Biomédica en Red de Enfermedades Hepáticas y Digestivas CIBEREHED, Barcelona, Spain Instituto Reina Sofia de Investigación Nefrológica, Barcelona, Spain
    Hepatology 59:1505-13. 2014
  9. ncbi request reprint Renal failure in patients with cirrhosis and sepsis unrelated to spontaneous bacterial peritonitis: value of MELD score
    Carlos Terra
    Liver Unit, Hospital Clinic, Universitat de Barcelona, Barcelona, Spain
    Gastroenterology 129:1944-53. 2005
  10. ncbi request reprint Increased plasma levels of neuropeptide Y in hepatorenal syndrome
    Juan Uriz
    Liver Unit, Institut de Malalties Digestives, Hospital Clinic, Barcelona, Spain
    J Hepatol 36:349-55. 2002

Collaborators

Detail Information

Publications42

  1. doi request reprint Clinical course and short-term mortality of cirrhotic patients with infections other than spontaneous bacterial peritonitis
    Javier Fernandez
    Liver Unit, Hospital Clinic, Barcelona, Spain
    Liver Int . 2016
    ..We assessed the prevalence of acute kidney injury (AKI) and type-1 hepatorenal syndrome (HRS), hospital, 30-day and 90-day mortality and risk factors of death in 441 decompensated patients...
  2. doi request reprint Management of bacterial infections in cirrhosis
    Javier Fernandez
    Liver Unit, IMDiM, Hospital Clinic, Universidad de Barcelona, IDIBAPS and Ciberehd, Barcelona, Spain
    J Hepatol 56:S1-12. 2012
    ..This review is focused on the currently recommended diagnostic, therapeutic and prophylactic strategies for bacterial infections in the cirrhotic population...
  3. doi request reprint Prevalence and risk factors of infections by multiresistant bacteria in cirrhosis: a prospective study
    Javier Fernandez
    Liver Unit, Hospital Clinic, University of Barcelona, Barcelona, Spain
    Hepatology 55:1551-61. 2012
    ..45), and recent use of β-lactams (HR, 2.39) were independently associated with the development of multiresistant infections. Results in the second series were similar to those observed in the first series...
  4. ncbi request reprint [Adrenal insufficiency in cirrhosis]
    Javier Fernandez
    IMDiM, IDIBAPS, Hospital Clinic, Universidad de Barcelona, CIBERehd, Barcelona, Espana
    Gastroenterol Hepatol 31:606-11. 2008
    ..This chapter summarizes the main aspects of the physiopathology, diagnosis and treatment of this entity in patients with acute or chronic liver disease...
  5. ncbi request reprint Adrenal insufficiency in patients with cirrhosis and septic shock: Effect of treatment with hydrocortisone on survival
    Javier Fernandez
    Liver Unit, Department of Surgery and Centro de Investigaciones Biomédicas Esther Koplowitz, IMDiM, IDIBAPS, Hospital Clinic, University of Barcelona, Spain
    Hepatology 44:1288-95. 2006
    ..Hydrocortisone administration in these patients is associated with a high frequency of shock resolution and high survival rate...
  6. ncbi request reprint A randomized unblinded pilot study comparing albumin versus hydroxyethyl starch in spontaneous bacterial peritonitis
    Javier Fernandez
    Liver Unit, IMDM and IDIBAPS, Hospital Clinic, University of Barcelona, Spain
    Hepatology 42:627-34. 2005
    ..This effect is due not only to volume expansion but also to an action on the peripheral arterial circulation...
  7. ncbi request reprint Effect of intravenous albumin on systemic and hepatic hemodynamics and vasoactive neurohormonal systems in patients with cirrhosis and spontaneous bacterial peritonitis
    Javier Fernandez
    Liver Unit, IMD, IDIBAPS, Hospital Clinic, University of Barcelona, Barcelona, Spain
    J Hepatol 41:384-90. 2004
    ..Albumin administration prevents renal failure and improves survival in spontaneous bacterial peritonitis. This study characterizes the mechanisms of action of albumin in this condition...
  8. doi request reprint Type-1 hepatorenal syndrome associated with infections in cirrhosis: natural history, outcome of kidney function, and survival
    Rogelio Barreto
    Liver Unit, Hospital Clinic, University of Barcelona, Barcelona, Catalunya, Spain Institut d Investigacions Biomèdiques August Pi Sunyer IDIBAPS, Barcelona, Spain Centro de Investigación Biomédica en Red de Enfermedades Hepáticas y Digestivas CIBEREHED, Barcelona, Spain Instituto Reina Sofia de Investigación Nefrológica, Barcelona, Spain
    Hepatology 59:1505-13. 2014
    ..Factors associated with poor prognosis were baseline serum bilirubin, no reversibility of type-1 HRS, lack of resolution of the infection, and development of septic shock after diagnosis of type-1 HRS...
  9. ncbi request reprint Renal failure in patients with cirrhosis and sepsis unrelated to spontaneous bacterial peritonitis: value of MELD score
    Carlos Terra
    Liver Unit, Hospital Clinic, Universitat de Barcelona, Barcelona, Spain
    Gastroenterology 129:1944-53. 2005
    ..Background &..
  10. ncbi request reprint Increased plasma levels of neuropeptide Y in hepatorenal syndrome
    Juan Uriz
    Liver Unit, Institut de Malalties Digestives, Hospital Clinic, Barcelona, Spain
    J Hepatol 36:349-55. 2002
    ..To investigate the relationship between neuropeptide Y (NPY), a potent renal vasoconstrictor peptide released upon marked stimulations of sympathetic nervous system (SNS), and renal and circulatory function in cirrhosis...
  11. doi request reprint Relative adrenal insufficiency in decompensated cirrhosis: Relationship to short-term risk of severe sepsis, hepatorenal syndrome, and death
    Juan Acevedo
    Liver Unit, Hospital Clinic, University of Barcelona, Barcelona, Spain Institut d Investigacions Biomèdiques August Pi Sunyer IDIBAPS, Barcelona, Spain Centro de Investigación Biomédica en Red de Enfermedades Hepáticas y Digestivas CIBEREHED, Barcelona, Spain
    Hepatology 58:1757-65. 2013
    ..008), severe sepsis (27% versus 9%, P = 0.003), type-1 hepatorenal syndrome (HRS) (16% versus 3%, P = 0.002), and death (22% versus 7%, P = 0.01)...
  12. ncbi request reprint Norfloxacin vs ceftriaxone in the prophylaxis of infections in patients with advanced cirrhosis and hemorrhage
    Javier Fernandez
    IMDM and IDIBAPS, Liver Unit, Hospital Clinic, University of Barcelona, Villaroel 170, 08036 Barcelona, Spain
    Gastroenterology 131:1049-56; quiz 1285. 2006
    ..This randomized controlled trial was aimed to compare oral norfloxacin vs intravenous ceftriaxone in the prophylaxis of bacterial infection in cirrhotic patients with gastrointestinal bleeding...
  13. doi request reprint Albumin for bacterial infections other than spontaneous bacterial peritonitis in cirrhosis. A randomized, controlled study
    Monica Guevara
    Liver Unit, Hospital Clinic, University of Barcelona, Barcelona, Catalunya, Spain
    J Hepatol 57:759-65. 2012
    ..Whether albumin has similar beneficial effects in patients with infections other than SBP is unknown...
  14. doi request reprint Renal failure and hyponatremia in patients with cirrhosis and skin and soft tissue infection. A retrospective study
    Gustavo Pereira
    University of Barcelona, Barcelona, Spain
    J Hepatol 56:1040-6. 2012
    ..This study aimed at assessing the characteristics, occurrence of renal failure, and outcome of cirrhotic patients with skin and soft tissue infection...
  15. doi request reprint A modified acute kidney injury classification for diagnosis and risk stratification of impairment of kidney function in cirrhosis
    Claudia Fagundes
    Liver Unit, Hospital Clinic, University of Barcelona, Barcelona, Catalunya, Spain
    J Hepatol 59:474-81. 2013
    ..The Acute Kidney Injury Network (AKIN) criteria are widely used in nephrology, but information on cirrhosis is limited. We aimed at evaluating the AKIN criteria and their relationship with the cause of kidney impairment and survival...
  16. ncbi request reprint Bacterial infections in cirrhosis: epidemiological changes with invasive procedures and norfloxacin prophylaxis
    Javier Fernandez
    Liver Unit, IMD, and Department of Microbiology and IDIBAPS, Hospital Clinic, University of Barcelona, Barcelona, Spain
    Hepatology 35:140-8. 2002
    ..Quinolone-resistant spontaneous bacterial peritonitis constitutes an emergent problem in patients on long-term norfloxacin prophylaxis, with trimethoprim-sulfamethoxazole not being a valid alternative...
  17. doi request reprint Prognostic importance of the cause of renal failure in patients with cirrhosis
    Marta Martín-Llahí
    Liver Unit, Hospital Clinic, University of Barcelona, Barcelona, Spain
    Gastroenterology 140:488-496.e4. 2011
    ..The prognostic value of the different causes of renal failure in cirrhosis is not well established. This study investigated the predictive value of the cause of renal failure in cirrhosis...
  18. doi request reprint Treatment of type 2 hepatorenal syndrome in patients awaiting transplantation: Effects on kidney function and transplantation outcomes
    Ezequiel Rodríguez
    Liver Unit, Hospital Clinic, University of Barcelona, Barcelona, Catalunya, Spain
    Liver Transpl 21:1347-54. 2015
    ..In conclusion, treatment of patients with type 2 HRS with terlipressin and albumin does not appear to have beneficial effects either in pretransplantation or in posttransplantation outcomes...
  19. doi request reprint Impact of chronic liver disease in intensive care unit acquired pneumonia: a prospective study
    Marta Di Pasquale
    Servei de Pneumologia, Institut del Tòrax, Hospital Clinic, IDIBAPS, Universitat de Barcelona, Barcelona, Spain
    Intensive Care Med 39:1776-84. 2013
    ..To assess the impact of chronic liver disease (CLD) on ICU-acquired pneumonia...
  20. ncbi request reprint Increased carbon monoxide production in patients with cirrhosis with and without spontaneous bacterial peritonitis
    Dara de Las Heras
    Liver Unit, Department of Pulmonary Medicine, and Hormonal Laboratory, Hospital Clinic, University of Barcelona, Catalunya, Spain
    Hepatology 38:452-9. 2003
    ..Increased CO production may participate in the disturbance of circulatory function that occurs during severe bacterial infections in cirrhosis...
  21. doi request reprint Urinary neutrophil gelatinase-associated lipocalin as biomarker in the differential diagnosis of impairment of kidney function in cirrhosis
    Claudia Fagundes
    Liver Unit, Hospital Clinic, University of Barcelona, Barcelona, Catalunya, Spain
    J Hepatol 57:267-73. 2012
    ..We aimed at assessing the usefulness of neutrophil gelatinase-associated lipocalin (NGAL), a biomarker of tubular damage, in the differential diagnosis of impairment of kidney function in cirrhosis...
  22. pmc Analysis of a urinary biomarker panel for clinical outcomes assessment in cirrhosis
    Xavier Ariza
    Liver Unit, Hospital Clinic, University of Barcelona, Barcelona, Catalunya, Spain Institut d Investigacions Biomèdiques August Pi Sunyer IDIBAPS, Barcelona, Spain Centro de Investigación Biomédica en Red de Enfermedades Hepáticas y Digestivas CIBEREHED, Barcelona, Spain Instituto Reina Sofía de Investigación Nefrológica IRSIN, Barcelona, Spain
    PLoS ONE 10:e0128145. 2015
    ..Biomarkers are potentially useful in assessment of outcomes in patients with cirrhosis, but information is very limited. Given the large number of biomarkers, adequate choice of which biomarker(s) to investigate first is important...
  23. doi request reprint Severe acute kidney injury associated with non-steroidal anti-inflammatory drugs in cirrhosis: A case-control study
    Chiara Elia
    Liver Unit, Hospital Clinic, University of Barcelona, Barcelona, Catalonia, Spain Institut d Investigacions Biomèdiques August Pi Sunyer IDIBAPS, Spain Centro de Investigación Biomédica en Red de Enfermedades Hepáticas y Digestivas CIBEREHED, Spain Instituto Reina Sofía de Investigación Nefrológica IRSIN, Spain
    J Hepatol 63:593-600. 2015
    ..The aim of the study was to investigate the characteristics and outcome of Acute Kidney Injury (AKI) developing in patients with cirrhosis treated with NSAIDs...
  24. doi request reprint Urinary neutrophil gelatinase-associated lipocalin predicts kidney outcome and death in patients with cirrhosis and bacterial infections
    Rogelio Barreto
    Liver Unit, Hospital Clinic, University of Barcelona, Barcelona, Catalunya, Spain Institut d Investigacions Biomèdiques August Pi Sunyer IDIBAPS, Spain Centro de Investigación Biomédica en Red de Enfermedades Hepáticas y Digestivas CIBEREHED, Spain Instituto Reina Sofía de Investigación Nefrológica IRSIN, Spain
    J Hepatol 61:35-42. 2014
    ..We aimed at assessing the value of urinary neutrophil gelatinase-associated lipocalin (uNGAL), a biomarker overexpressed in kidney tubules during kidney injury, in predicting clinical outcomes in cirrhosis with infections...
  25. ncbi request reprint Primary prophylaxis of spontaneous bacterial peritonitis delays hepatorenal syndrome and improves survival in cirrhosis
    Javier Fernandez
    Liver Unit, Hospital Clinic Barcelona, Barcelona, Spain
    Gastroenterology 133:818-24. 2007
    ..Norfloxacin is highly effective in preventing spontaneous bacterial peritonitis recurrence in cirrhosis, but its role in the primary prevention of this complication is uncertain...
  26. doi request reprint Terlipressin and albumin for type-1 hepatorenal syndrome associated with sepsis
    Ezequiel Rodríguez
    Liver Unit, Hospital Clinic, University of Barcelona, Barcelona, Catalunya, Spain Institut d Investigacions Biomèdiques August Pi Sunyer IDIBAPS, Spain Centro de Investigación Biomédica en Red de Enfermedades Hepáticas y Digestivas CIBEREHED, Spain Instituto Reina Sofía de Investigación Nefrológica IRSIN, Spain
    J Hepatol 60:955-61. 2014
    ..Study aim was to investigate the effects of early treatment with terlipressin and albumin on circulatory and kidney function in patients with type-1 HRS and sepsis and assess factors predictive of response to therapy...
  27. ncbi request reprint Failure of Lactobacillus spp. to prevent bacterial translocation in a rat model of experimental cirrhosis
    Tilman Martin Bauer
    Liver Unit, Institut Malalties Digestives, Hospital Clinic, IDIBAPS, University of Barcelona, Barcelona, Spain
    J Hepatol 36:501-6. 2002
    ..We investigated whether an alternative strategy with Lactobacillus prevents bacterial translocation and ascitic fluid infection in cirrhotic rats...
  28. doi request reprint Management of critically-ill cirrhotic patients
    Pere Gines
    Liver Unit, IMDiM, Hospital Clinic Barcelona, University of Barcelona and IDIBAPS and Ciberehd, Barcelona, Spain
    J Hepatol 56:S13-24. 2012
    ..This review will focus on the diagnostic approach and treatment strategies currently recommended in the critical care management of patients with cirrhosis...
  29. doi request reprint Hyponatremia in patients treated with terlipressin for severe gastrointestinal bleeding due to portal hypertension
    Elsa Solá
    Liver Unit, Hospital Clinic, University of Barcelona, Barcelona, Catalunya, Spain
    Hepatology 52:1783-90. 2010
    ....
  30. doi request reprint Plasma copeptin as biomarker of disease progression and prognosis in cirrhosis
    Elsa Solá
    Liver Unit, Hospital Clinic, University of Barcelona, Barcelona, Spain Institut D investigacions Biomèdiques August Pi i Sunyer IDIBAPS, Barcelona, Spain Centro de Investigación Biomédica en Red de Enfermedades Hepáticas y Digestivas CIBERehd, Spain Electronic address
    J Hepatol 65:914-920. 2016
    ..Copeptin could have a role as biomarker of prognosis in cirrhosis as it may reflect circulatory dysfunction. The aim of this study is to investigate the role of copeptin as biomarker of disease progression and prognosis in cirrhosis...
  31. doi request reprint Validation of a Staging System for Acute Kidney Injury in Patients With Cirrhosis and Association With Acute-on-Chronic Liver Failure
    Patricia Huelin
    Liver Unit, Hospital Clinic, University of Barcelona, Barcelona, Catalonia, Spain Institut d Investigacions Biomèdiques Agust Pi i Sunyer, Barcelona, Spain Centro de Investigación Biomédica en Red de Enfermedades Hepáticas y Digestivas, Barcelona, Spain
    Clin Gastroenterol Hepatol . 2016
    ....
  32. doi request reprint Management of hepatorenal syndrome in patients with cirrhosis
    Vicente Arroyo
    Liver Unit, Hospital Clinic Barcelona, University of Barcelona, Villarroel 170, Barcelona, Catalonia 08036, Spain
    Nat Rev Nephrol 7:517-26. 2011
    ..Albumin dialysis is a potentially effective treatment for type 1 HRS still under investigation. Patients with type 2 HRS are treated with repeated large-volume paracentesis or TIPS...
  33. doi request reprint Pathogenesis and treatment of hepatorenal syndrome
    Vicente Arroyo
    Liver Unit, Institute of Digestive and Metabolic Diseases, CIBERehd, Hospital Clinic, University of Barcelona, Spain
    Semin Liver Dis 28:81-95. 2008
    ..However, effective treatments of HRS (vasoconstrictors associated with intravenous albumin, transjugular intrahepatic portacaval shunt, albumin dialysis) that can improve survival have recently been introduced...
  34. doi request reprint [Evaluation and treatment of the critically ill cirrhotic patient]
    Javier Fernandez
    Liver Unit, Hospital Clinic, Universitat de Barcelona, Institut d Investigacions Biomediques August Pi i Sunyer, CIBERehd, Barcelona, Espana
    Gastroenterol Hepatol 39:607-626. 2016
    ..This article describes the recommendations agreed upon at the consensus meetings and their main conclusions...
  35. ncbi request reprint Venous Thrombotic Events After Liver Transplantation
    Annabel Blasi
    Anesthesia Department, Hospital Clinic de Barcelona, Barcelona, Spain
    Clin Appl Thromb Hemost . 2016
    ..5%. Our results suggest that thromboprophylaxis should be considered after LT in patients with cirrhosis grouped as Child A and in patients who undergo intraoperative thrombectomy...
  36. ncbi request reprint Increased apoptosis dependent on caspase-3 activity in polymorphonuclear leukocytes from patients with cirrhosis and ascites
    Maria Jose Ramirez
    Liver Unit, Hospital Clinic Universitari, Institut d Investigacions Biomediques August Pi i Sunyer, University of Barcelona, Barcelona, Spain
    J Hepatol 41:44-8. 2004
    ..The aim of the current study was to investigate whether the presence of increased PMN apoptosis could also contribute to the appearance of neutropenia in these patients...
  37. ncbi request reprint Pathophysiological basis of albumin use in cirrhosis
    Vicente Arroyo
    Liver Unit, Institut de Malalties Digestives i Metaboliques, Hospital Clinic and Institut d Investigacions Biomèdiques August Pi i Sunyer, University of Barcelona, Barcelona, Spain
    Ann Hepatol 10:S6-14. 2011
    ..Impairment of albumin function is one of the most characteristic traits of cirrhosis. Administration of exogenous albumin could be beneficial because of its positive effects on microcirculation...
  38. doi request reprint Acute-on-Chronic Liver Failure: The Role of Precipitating Illness
    Elsa Solá
    Liver Unit, Hospital Clinic of Barcelona, University of Barcelona, Institut d Investigacions Biomediques August Pi i Sunyer IDIBAPS, Centro de Investigacion Biomedica en Red de Enfermedades Hepaticas y Digestivas CIBERehd, Barcelona, Spain
    Semin Liver Dis 36:117-22. 2016
    ..It is suggested that in these patients, bacterial products derived from bacterial translocation or damage-associated molecular patterns resulting from injured liver tissue cells may act as triggering factors. ..
  39. doi request reprint Changing options for prevention and treatment of infections in cirrhosis
    Juan Acevedo
    Gastroenterology and Hepatology Department, Hospital Sant Jaume de Calella, Sant Jaume 209 217, 08370, Catalunya, Barcelona, Spain
    Curr Treat Options Gastroenterol 12:256-67. 2014
    ..Restriction of antibiotic prophylaxis to the high-risk populations, prevention of antibiotic overuse, and early de-escalation policies are also mandatory to prevent the spread of MDR bacteria in cirrhosis...
  40. pmc Systemic inflammatory response and serum lipopolysaccharide levels predict multiple organ failure and death in alcoholic hepatitis
    Javier Michelena
    Liver Unit, Hospital Clinic, Barcelona, Spain
    Hepatology 62:762-72. 2015
    ..All of them predicted mortality. Procalcitonin, but not high-sensitivity C-reactive protein, serum levels identified those patients with SIRS and infection. Lipopolysaccharide serum levels predicted MOF and the response to prednisolone...
  41. doi request reprint New antibiotic strategies in patients with cirrhosis and bacterial infection
    Javier Fernandez
    a Liver Unit, Hospital Clinic Barcelona, University of Barcelona, Barcelona, Spain
    Expert Rev Gastroenterol Hepatol 9:1495-500. 2015
    ..Early de-escalation policies are recommended to prevent the spread of MDR bacteria in cirrhosis. ..
  42. doi request reprint Stroke volume response to liver graft reperfusion stress in cirrhotic patients
    Bibiana Escobar
    Department of Anesthesiology, Hospital Clinic, Barcelona, Spain
    World J Surg 38:927-35. 2014
    ..In patients with advanced cirrhosis, stressful stimuli may reveal a silent reduced cardiac performance. During liver transplantation (LT), graft reperfusion strongly stresses the heart and may unmask latent myocardial dysfunction...