Gines Escolar

Summary

Country: Spain

Publications

  1. ncbi request reprint Uremic platelet dysfunction: past and present
    Gines Escolar
    Servicio de Hemoterapia y Hemostasia and Servicio de Nefrología, Hospital Clinic, University of Barcelona, Villarroel 170, 08036 Barcelona, Spain
    Curr Hematol Rep 4:359-67. 2005
  2. doi request reprint Dosing of rivaroxaban by indication: getting the right dose for the patient
    Gines Escolar
    a 1 University of Barcelona, Centre de Diagnostic Biomedic CDB, Department of Hemotherapy and Hemostasis, Barcelona, Spain 34 9 32 27 54 00, Ext 2571 34 9 32 27 93 69
    Expert Opin Drug Metab Toxicol 11:1665-77. 2015
  3. doi request reprint The pharmacokinetics of edoxaban for the prevention and treatment of venous thromboembolism
    Gines Escolar
    Universitat de Barcelona, Hematologist, Hospital Clinic, Servicio de Hemoterapia y Hemostasia, Villarroel 170, 08036 Barcelona, Spain 34 93 227 54 00 Ext 2571 34 93 227 93 69
    Expert Opin Drug Metab Toxicol 10:445-58. 2014
  4. doi request reprint Apixaban in the prevention of stroke and systemic embolism in nonvalvular atrial fibrillation
    L Pujadas-Mestres
    Medical Department, Bristol Myers Squibb, Madrid, Spain
    Drugs Today (Barc) 49:425-36. 2013
  5. ncbi request reprint Serotonergic mechanisms: a potential link between affective disorders and cardiovascular risk
    Gines Escolar
    Servicio de Hemoterapia y Hemostasia, Hospital Clinic, Institut d Investigacions Biomediques August Pi i Sunyer IDIBAPS, Faculty of Medicine, University of Barcelona, Barcelona, Spain
    Drugs Today (Barc) 41:721-43. 2005
  6. ncbi request reprint Argatroban: a direct thrombin inhibitor with reliable and predictable anticoagulant actions
    Gines Escolar
    Servicio de Hemoterapia y Hemostasia, Centre de Diagnostic Biomedic CDB, Hospital Clinic, University of Barcelona, Barcelona, Spain
    Drugs Today (Barc) 42:223-36. 2006
  7. doi request reprint Internalization of tissue factor by platelets
    Gines Escolar
    Servicio de Hemoterapia y Hemostasia, Hospital Clinic, Centre de Diagnostic Biomedic, IDIBAPS, Universidad de Barcelona, Spain
    Thromb Res 122:S37-41. 2008
  8. ncbi request reprint Inhibition of tyrosine kinase activity prevents the adhesive and cohesive properties of platelets and the expression of procoagulant activity in response to collagen
    Maribel Diaz-Ricart
    Servicio de Hemoterapia Hemostasia, Hospital Clinic, IDIBAPS, Universidad de Barcelona, Spain
    Thromb Res 121:873-83. 2008
  9. doi request reprint Serotonin enhances platelet procoagulant properties and their activation induced during platelet tissue factor uptake
    Irene Lopez-Vilchez
    Servicio de Hemoterapia y Hemostasia, Hospital Clinic, Centro de Diagnostico Biomedico, Instituto de Investigaciones Biomedicas August Pi i Sunyer, Universidad de Barcelona, Villarroel 170, 08036 Barcelona, Spain
    Cardiovasc Res 84:309-16. 2009
  10. doi request reprint Internalization of Tissue Factor-Rich Microvesicles by Platelets Occurs Independently of GPIIb-IIIa, and Involves CD36 Receptor, Serotonin Transporter and Cytoskeletal Assembly
    Irene Lopez-Vilchez
    Department of Hemotherapy and Hemostasis, Hospital Clinic, Centre of Biomedical Diagnosis CDB, Institute of Biomedical Research August Pi i Sunyer IDIBAPS, University of Barcelona, 170 Villarroel Street, Barcelona 08036, Spain
    J Cell Biochem 117:448-57. 2016

Collaborators

Detail Information

Publications74

  1. ncbi request reprint Uremic platelet dysfunction: past and present
    Gines Escolar
    Servicio de Hemoterapia y Hemostasia and Servicio de Nefrología, Hospital Clinic, University of Barcelona, Villarroel 170, 08036 Barcelona, Spain
    Curr Hematol Rep 4:359-67. 2005
    ..Emphasized is the delicate balance of hemostasis in the uremic condition, in which deficient hemostasis paradoxically coexists with accelerated atherosclerosis and an enhanced risk of thrombosis...
  2. doi request reprint Dosing of rivaroxaban by indication: getting the right dose for the patient
    Gines Escolar
    a 1 University of Barcelona, Centre de Diagnostic Biomedic CDB, Department of Hemotherapy and Hemostasis, Barcelona, Spain 34 9 32 27 54 00, Ext 2571 34 9 32 27 93 69
    Expert Opin Drug Metab Toxicol 11:1665-77. 2015
    ..The direct oral anticoagulants rivaroxaban , dabigatran, apixaban, and, most recently, edoxaban have been approved for the management of specific thromboembolic indications...
  3. doi request reprint The pharmacokinetics of edoxaban for the prevention and treatment of venous thromboembolism
    Gines Escolar
    Universitat de Barcelona, Hematologist, Hospital Clinic, Servicio de Hemoterapia y Hemostasia, Villarroel 170, 08036 Barcelona, Spain 34 93 227 54 00 Ext 2571 34 93 227 93 69
    Expert Opin Drug Metab Toxicol 10:445-58. 2014
    ..A series of new oral anticoagulants with powerful and reliable antithrombotic actions have been developed in the last decade...
  4. doi request reprint Apixaban in the prevention of stroke and systemic embolism in nonvalvular atrial fibrillation
    L Pujadas-Mestres
    Medical Department, Bristol Myers Squibb, Madrid, Spain
    Drugs Today (Barc) 49:425-36. 2013
    ....
  5. ncbi request reprint Serotonergic mechanisms: a potential link between affective disorders and cardiovascular risk
    Gines Escolar
    Servicio de Hemoterapia y Hemostasia, Hospital Clinic, Institut d Investigacions Biomediques August Pi i Sunyer IDIBAPS, Faculty of Medicine, University of Barcelona, Barcelona, Spain
    Drugs Today (Barc) 41:721-43. 2005
    ..The present review seeks a better understanding of the mechanisms that could link depression with an enhanced cardiovascular risk...
  6. ncbi request reprint Argatroban: a direct thrombin inhibitor with reliable and predictable anticoagulant actions
    Gines Escolar
    Servicio de Hemoterapia y Hemostasia, Centre de Diagnostic Biomedic CDB, Hospital Clinic, University of Barcelona, Barcelona, Spain
    Drugs Today (Barc) 42:223-36. 2006
    ....
  7. doi request reprint Internalization of tissue factor by platelets
    Gines Escolar
    Servicio de Hemoterapia y Hemostasia, Hospital Clinic, Centre de Diagnostic Biomedic, IDIBAPS, Universidad de Barcelona, Spain
    Thromb Res 122:S37-41. 2008
    ..TF carried by platelets could play a potential role in platelet thrombus formation and by extension in the development of ischemic complications...
  8. ncbi request reprint Inhibition of tyrosine kinase activity prevents the adhesive and cohesive properties of platelets and the expression of procoagulant activity in response to collagen
    Maribel Diaz-Ricart
    Servicio de Hemoterapia Hemostasia, Hospital Clinic, IDIBAPS, Universidad de Barcelona, Spain
    Thromb Res 121:873-83. 2008
    ..Platelet activation leads to signal transduction mechanisms, in which phosphotyrosine proteins play a relevant role...
  9. doi request reprint Serotonin enhances platelet procoagulant properties and their activation induced during platelet tissue factor uptake
    Irene Lopez-Vilchez
    Servicio de Hemoterapia y Hemostasia, Hospital Clinic, Centro de Diagnostico Biomedico, Instituto de Investigaciones Biomedicas August Pi i Sunyer, Universidad de Barcelona, Villarroel 170, 08036 Barcelona, Spain
    Cardiovasc Res 84:309-16. 2009
    ..We have investigated the involvement of serotonergic mechanisms facilitating the interaction of human platelets with TF-MVs. Inhibitory strategies aimed at blocking serotonin and coagulation mechanisms were also studied...
  10. doi request reprint Internalization of Tissue Factor-Rich Microvesicles by Platelets Occurs Independently of GPIIb-IIIa, and Involves CD36 Receptor, Serotonin Transporter and Cytoskeletal Assembly
    Irene Lopez-Vilchez
    Department of Hemotherapy and Hemostasis, Hospital Clinic, Centre of Biomedical Diagnosis CDB, Institute of Biomedical Research August Pi i Sunyer IDIBAPS, University of Barcelona, 170 Villarroel Street, Barcelona 08036, Spain
    J Cell Biochem 117:448-57. 2016
    ..CD36 and SERT appear as potential therapeutic targets to interfere with the association of TF+MVs with platelets and possibly downregulate their prothrombotic phenotype...
  11. ncbi request reprint Platelet adhesion onto a polystyrene surface under static conditions: role of specific platelet receptors and effect of divalent cations
    Marta Carretero
    Servico Hemoterapia y Hemostasia, Hospital Clinic, IDIBAPS, Barcelona, Spain
    Platelets 13:77-83. 2002
    ....
  12. doi request reprint Relative contributions of collagen and tissue factor to thrombus formation on damaged vascular vessels: in-vitro studies with circulating blood
    Irene Lopez-Vilchez
    Servei d Hemoterapia i Hemostasia, Hospital Clinic, Centre de Diagnostic Biomedic, Institut d Investigacions Biomediques August Pi i Sunyer, Universitat de Barcelona, Barcelona, Spain
    Coron Artery Dis 20:392-9. 2009
    ..Thrombogenicity of ruptured atherosclerotic plaques is mainly attributed to the exposure of collagen (Col) and tissue factor (TF). Using in-vitro approaches, we explored the relative contribution of Col and TF to local thrombogenesis...
  13. doi request reprint External calcium facilitates signalling, contractile and secretory mechanisms induced after activation of platelets by collagen
    Gemma Arderiu
    Servei d Hemoterapia Hemostasia, Hospital Clinic, IDIBAPS, Universitat de Barcelona, Villarroel, 170, 08036 Barcelona, Spain
    Platelets 19:172-81. 2008
    ..In addition, our results confirm that entrance of exogenous Ca2+ depends on a functional cytoskeleton...
  14. doi request reprint Serotonergic mechanisms enhance platelet-mediated thrombogenicity
    Ana M Galan
    Servicio de Hemoterapia Hemostaia, Hospital Clinic, CDB, IDIBAPS, UB, 08036 Barcelona, Spain
    Thromb Haemost 102:511-9. 2009
    ..The remarkable antithrombotic actions achieved through SSRI deserve further mechanistic and clinical investigations...
  15. ncbi request reprint Tissue factor-enriched vesicles are taken up by platelets and induce platelet aggregation in the presence of factor VIIa
    Irene Lopez-Vilchez
    Servicio de Hemoterapia Hemostasia, Hospital Clinic, Centre de Deagnostic biomedic, IDIBAPS, Universidad de Barcelona, Spain
    Thromb Haemost 97:202-11. 2007
    ..Our findings may explain the hemostatic action of rFVIIa in severely hemodiluted patients, but are also relevant for the understanding of potential implications of TF-associated to platelets in the propagation of thrombus...
  16. doi request reprint Hormonal responses to the 5-HT1A agonist buspirone in remitted endogenous depressive patients after long-term imipramine treatment
    Esther Gomez-Gil
    Servicio de Psiquiatria, Instituto de Neurociencias, Hospital Clinic, Instituto de Investigaciones Biomédiques August Pi i Sunyer IDIBAPS, Facultad de Medicina, Universidad de Barcelona, Barcelona, Spain
    Psychoneuroendocrinology 35:481-9. 2010
    ..The present study aimed to investigate the adaptive effect of the TCA imipramine on the post-synaptic 5-HT1A receptor function in the hypothalamus...
  17. pmc Redistribution and hemostatic action of recombinant activated factor VII associated with platelets
    Irene Lopez-Vilchez
    Hemotherapy and Hemostasis Service, Hospital Clinic, Biomedical Diagnostics Center CDB, Institute of Biomedical Research August Pi i Sunyer IDIBAPS, University of Barcelona, Barcelona, Spain
    Am J Pathol 178:2938-48. 2011
    ..Redistribution of rFVIIa into platelets may explain the prolonged prophylactic effectiveness of rFVIIa in hemophilia...
  18. pmc Reversal of apixaban induced alterations in hemostasis by different coagulation factor concentrates: significance of studies in vitro with circulating human blood
    Gines Escolar
    Department of Hemotherapy Hemostasis, Hospital Clinic, Centre de Diagnostic Biomedic, Institut d Investigacions Biomediques August Pi i Sunyer, Universitat de Barcelona, Barcelona, Spain
    PLoS ONE 8:e78696. 2013
    ..Our results indicate that rFVIIa, PCCs and aPCCs have the potential to restore platelet and fibrin components of the hemostasis previously altered by apixaban. ..
  19. pmc Impact of experimental haemodilution on platelet function, thrombin generation and clot firmness: effects of different coagulation factor concentrates
    Carolina Caballo
    Haemotherapy Haemostasis Department, Hospital Clinic, IDIBAPS, Barcelona, Spain
    Blood Transfus 11:391-9. 2013
    ..Haemodilution during resuscitation after massive haemorrhage may worsen the coagulopathy and perpetuate bleeding...
  20. ncbi request reprint Efficient tyrosine phosphorylation of proteins after activation of platelets with thrombin depends on intact glycoprotein Ib
    Maribel Diaz-Ricart
    Servicio de Hemoterapia y Hemostasia, Hospital Clinic, IDIBAPS, Barcelona, Spain
    Platelets 16:453-61. 2005
    ..Moreover, our results indicate that both receptors, GPIb and PAR-1, are necessary to achieve a full platelet response to thrombin...
  21. doi request reprint Automated preparation of whole blood-derived platelets suspended in two different platelet additive solutions and stored for 7 days
    Joan Cid
    Department of Hemotherapy and Hemostasis, CDB, IDIBAPS, Hospital Clinic, University de Barcelona and the Banc de Sang i Teixits, Barcelona, Spain
    Transfusion 54:426-33. 2014
    ..The aim of our study was to compare the in vitro PLT quality of PCs obtained with either the Atreus 2C+ and the OrbiSac or the Atreus 3C and suspended in PAS-II or PAS-IIIM during storage for up to 7 days...
  22. ncbi request reprint Erythropoietin triggers a signaling pathway in endothelial cells and increases the thrombogenicity of their extracellular matrices in vitro
    Berta Fuste
    Servicio de Hemoterapia Hemostasia, Hospital Clinic, IDIBAPS, Barcelona, Spain
    Thromb Haemost 88:678-85. 2002
    ..Our results indicate that rHuEPO has a direct action on the endothelium, increasing the reactivity of the underlying extracellular matrix towards platelets, effect that may be attributed to an increase in the expression of TF...
  23. ncbi request reprint Platelet membrane fragments enhance the procoagulant effect of recombinant factor VIIa in studies with circulating human blood under conditions of experimental thrombocytopenia
    Raul Tonda
    Servicio de Hemoterapia Hemostasia, Hospital Clinic, University of Barcelona, Spain
    Semin Hematol 41:157-62. 2004
    ..These studies support the concept that, under conditions of thrombocytopenia, both rFVIIa and platelet microvesicles enhance fibrin formation at sites of vascular damage...
  24. ncbi request reprint Uremic medium causes expression, redistribution and shedding of adhesion molecules in cultured endothelial cells
    Mireia Serradell
    Servicio de Hemoterapia Hemostasia, Hospital Clinic, IDIBAPS, University of Barcelona, Spain
    Haematologica 87:1053-61. 2002
    ....
  25. ncbi request reprint Granulocyte colony-stimulating factor increases expression of adhesion receptors on endothelial cells through activation of p38 MAPK
    Berta Fuste
    Servicio de Hemoterapia Hemostasia, Hospital Clinic, IDIBAPS, Barcelona, Spain
    Haematologica 89:578-85. 2004
    ..DESIGN AN METHODS: Endothelial cell monolayers were exposed to G-CSF to evaluate: i) signal transduction mechanisms, ii) expression of adhesion receptors at the cell surface, and iii) leukocyte adhesion on EC monolayers...
  26. doi request reprint Platelet-associated tissue factor enhances platelet reactivity and thrombin generation in experimental studies in vitro
    Irene Lopez-Vilchez
    Servicio de Hemoterapia y Hemostasia, Hospital Clinic, Centro de Diagnostico Biomedico, Instituto de Investigaciones Biomedicas August Pi i Sunyer, Universidad de Barcelona, Spain
    Thromb Res 130:e294-300. 2012
    ..The thrombogenic potential of tissue factor (TF) associated to platelets is controversial. We have investigated the in vitro contribution of platelet-associated TF to thrombus formation...
  27. ncbi request reprint Haemodialysis through a cellulose membrane induces dephosphorylation of CD11b and promotes leukocyte adhesion to endothelial cells
    M Rosa Hernandez
    Servei d Hemoterapia i Hemostasia, Hospital Clinic i Provincial, IDIBAPS, Universitat de Barcelona, Barcelona, Spain
    Clin Invest Med 32:E48-56. 2009
    ..To explore modifications in signal mechanisms involving CD11b and leukocyte adhesion in patients under haemodialysis (HD)...
  28. ncbi request reprint Hemostatic effect of activated recombinant factor VII (rFVIIa) in liver disease: studies in an in vitro model
    Raul Tonda
    Servicio de Hemoterapia Hemostasia, Hospital Clinic, Facultad de Medicina, IDIBAPS, Calle Villarroel 170, Barcelona 08036, Spain
    J Hepatol 39:954-9. 2003
    ..The exact mechanism of action of rFVIIa in this clinical condition is unknown. We have explored effects of rFVIIa on hemostasis in cirrhotic patients using an in vitro perfusion technique...
  29. doi request reprint Distinct deleterious effects of cyclosporine and tacrolimus and combined tacrolimus-sirolimus on endothelial cells: protective effect of defibrotide
    Alba Carmona
    Hemotherapy Hemostasis Department, Centre de Diagnostic Biomedic, Institut d Investigacions Biomediques August Pi i Sunyer, Hospital Clinic, Universitat de Barcelona, Barcelona, Spain
    Biol Blood Marrow Transplant 19:1439-45. 2013
    ..In conclusion, CSA and TAC+SIR had a proinflammatory effect, but only CSA exhibited an additional prothrombotic effect. Interestingly, DF exerted clear protective anti-inflammatory and antithrombotic effects on the endothelium...
  30. pmc TRAP induces more intense tyrosine phosphorylation than thrombin with differential ultrastructural features
    Berta Fuste
    Servicio de Hemoterapia y Hemostasia, Hospital Clinic, Institut d Investigacions Biomediques Agusti Pi Sunyer, Barcelona, Spain
    Am J Pathol 160:2245-52. 2002
    ..However, as derived from ultrastructural observations, TRAP seems to be less efficient in triggering cytoskeletal assembly and internal contraction in an organized manner in contrast with the natural protease...
  31. ncbi request reprint Glycoproteins expression on platelet membrane in inherited macrothrombocytopenias
    Silvia Perez-Pujol
    Department Hemotherapy and Hemostasis, Biomedical Diagnosis Center, Hospital Clinic Provincial, Augustí Pii Sunyé Research Institute IDIBAPS, University of Barcelona, Barcelona, Spain
    Thromb Res 112:233-7. 2003
    ..We have investigated the expression of constitutively expressed platelet membrane GP and the response to TRAP activation in a group of patients with different forms of inherited macrothrombocytopenias...
  32. pmc Liposomes bearing fibrinogen could potentially interfere with platelet interaction and procoagulant activity
    M Rosa Hernandez
    Department of Hemotherapy and Hemostasis, Hospital Clinic, CDB, IDIBAPS, UB, Barcelona, Spain
    Int J Nanomedicine 7:2339-47. 2012
    ..In the present study, we evaluated the modifications induced by multilamellar raw liposomes (MLV) or fibrinogen-coated liposomes (MLV-FBN) on hemostatic parameters...
  33. ncbi request reprint Effect of two different dialysis membranes on leukocyte adhesion and aggregation
    Maria Rosa Hernandez
    Servei d Hemoterapia i Hemostasia, IDIBAPS, Departament de Medicina, Universitat de Barcelona, Barcelona, Spain
    Nephron Clin Pract 106:c1-8. 2007
    ....
  34. ncbi request reprint Effects on primary haemostasis of an anti-inflammatory agent with 5-lipoxygenase and cyclooxygenase inhibitory activity
    Maria Rosa Hernandez
    Division of Haemotherapy and Haemostasis, Department of Medicine, Hospital Clínic i Provincial IDIBAPS, University of Barcelona, Barcelona, Spain
    J Cardiovasc Med (Hagerstown) 7:859-65. 2006
    ..The aim of this study was to investigate the in-vitro effects of licofelone on platelet function. Effects observed were compared with those produced by the classic COX-1 inhibitor aspirin (ASA)...
  35. doi request reprint Preanalytical treatment of EDTA-anticoagulated blood to ensure stabilization of the mean platelet volume and component measured with the ADVIA counters
    Maribel Diaz-Ricart
    Servicio de Hemoterapia Hemostasia, Centre de Diagnostic Biomedic, Hospital Clinic, Universitat de Barcelona, Villarroel 170, Barcelona 08036, Spain
    Thromb Res 126:e30-5. 2010
    ..Thus, the additives included in ED-WORTY may be useful for maintaining the stability of MPC for prolonged periods and to facilitate the transport and exchange of samples among institutions and laboratories...
  36. ncbi request reprint Effect of holding buffy coats 4 or 18 hours before preparing pooled filtered PLT concentrates in plasma
    Silvia Perez-Pujol
    Department of Hemotherapy and Hemostasis, Biomedical Diagnostic Center, Agusti Pi i Sunyer Biomedical Research Institute, Hospital Clinic Barcelona, Spain
    Transfusion 44:202-9. 2004
    ....
  37. doi request reprint Coagulation Factor Concentrates Fail to Restore Alterations in Fibrin Formation Caused by Rivaroxaban or Dabigatran in Studies With Flowing Blood From Treated Healthy Volunteers
    Eduardo Arellano-Rodrigo
    Service of Hemotherapy Hemostasis, Hospital Clinic, CDB, IDIBAPS, Barcelona, Spain
    Transfus Med Rev 29:242-9. 2015
    ....
  38. doi request reprint Impact of pathogen reduction technology and storage in platelet additive solutions on platelet function
    Ana M Galan
    Servicio de Hemoterapia y Hemostasia, Hospital Clinic, C Villarroel 170, Barcelona 08036, Spain
    Transfusion 51:808-15. 2011
    ..Our study has evaluated the effect of Mirasol PRT (CaridianBCT) followed by storage in PASs (PAS-III or PAS-IIIM) on analytical and functional characteristics of PLT concentrates (PCs)...
  39. ncbi request reprint Effects of etamsylate on equine platelets: in vitro and in vivo studies
    Didac Segura
    Servei de Medicina Interna Equina, Departament de Medicina i Cirurgia Animals, Facultat de Veterinaria, Universitat Autonoma de Barcelona, 08193 Bellaterra, Barcelona, Spain
    Vet J 174:325-9. 2007
    ..The results of the in vitro study indicate that etamsylate produces a pre-activation state in equine platelets, but this fact could be confirmed by the in vivo study...
  40. doi request reprint Differential expression of proteins from cultured endothelial cells exposed to uremic versus normal serum
    Carla Carbo
    Servicio de Hemoterapia Hemostasia y, Centre de Diagnostic Biomedic, Institut d Investigacions Biomediques August Pi i Sunyer IDIBAPS, Universitat de Barcelona, Barcelona, Spain
    Am J Kidney Dis 51:603-12. 2008
    ..We established an in vitro model of endothelial dysfunction by exposing endothelial cells to uremic media and applied a proteomic approach to characterize endothelial cell dysfunction in uremia...
  41. doi request reprint Quantitative and qualitative analysis of coagulation factors in cryoprecipitate prepared from fresh-frozen plasma inactivated with amotosalen and ultraviolet A light
    Joan Cid
    Hemotherapy Hemostasis Department, CDB, IDIBAPS, Hospital Clinic, University of Barcelona, Barcelona, Spain
    Transfusion 53:600-5. 2013
    ..The aim of this study was to analyze the quantity and quality of coagulation factors in cryoprecipitate prepared from FFP treated with amotosalen and UVA light...
  42. ncbi request reprint Increased local procoagulant action: a mechanism contributing to the favorable hemostatic effect of recombinant FVIIa in PLT disorders
    Ana Maria Galán
    Hematherapy and Hemostasis Service, Hospital Clinic, Faculty of Medicine, IDIBAPS, Barcelona, Spain
    Transfusion 43:885-92. 2003
    ....
  43. doi request reprint Endothelial dysfunction after hematopoietic stem cell transplantation: role of the conditioning regimen and the type of transplantation
    Marta Palomo
    Hemotherapy Hemostasis Department, Institut d Investigacions Biomediques August Pi i Sunyer, Universitat de Barcelona, Barcelona, Spain
    Biol Blood Marrow Transplant 16:985-93. 2010
    ..However, the comparative analysis between patients with and without complications suggests that none of these markers has diagnostic or prognostic value...
  44. doi request reprint Reversal of rivaroxaban-induced alterations on hemostasis by different coagulation factor concentrates – in vitro studies with steady and circulating human blood
    Gines Escolar
    Department of Haemotherapy and Haemostasis, Hospital Clinic, Centre of Biomedical Diagnosis, Institute of Biomedical Research August Pi i Sunyer, University of Barcelona, Spain
    Circ J 79:331-8. 2015
    ..Despite the good safety of rivaroxaban, there is limited information on strategies for urgent reversal of its antihemostatic effects...
  45. doi request reprint Fibrinogen nitrotyrosination after ischemic stroke impairs thrombolysis and promotes neuronal death
    Gerard Ill-Raga
    Laboratory of Molecular Physiology and Channelopathies, Universitat Pompeu Fabra, Barcelona, Catalonia 08003, Spain
    Biochim Biophys Acta 1852:421-8. 2015
    ....
  46. ncbi request reprint Decrease of the platelet 5-HT2A receptor function by long-term imipramine treatment in endogenous depression
    Esther Gomez-Gil
    Instituto Clínic de Psiquiatría y Psicología, Hospital Clinic, Villarroel, Barcelona, Spain
    Hum Psychopharmacol 19:251-8. 2004
    ....
  47. ncbi request reprint Uraemic medium accelerates proliferation but does not induce apoptosis of endothelial cells in culture
    Mireia Serradell
    Servicios de Hemoterapia Hemostasia, Hospital Clinic, IDIBAPS, Barcelona, Spain
    Nephrol Dial Transplant 18:1079-85. 2003
    ..Phosphorylation kinetics of the mitogen-activated protein kinase (MAPK) p42/44 and p38 were also evaluated...
  48. ncbi request reprint Physical stability of liposomes bearing hemostatic activity
    Elisenda Casals
    Departament de Fisicoquimica, Facultat de Farmacia, Universitat de Barcelona, Avda Joan XXIII s n, 08013, Barcelona, Catalonia, Spain
    Chem Phys Lipids 125:139-46. 2003
    ....
  49. ncbi request reprint Effects of Helicobacter pylori eradication on platelet activation and disease recurrence in patients with acute coronary syndromes
    J Ignasi Elizalde
    Gastroenterology Department, Institut Clinic de Malalties Digestives, University of Barcelona, Barcelona, Spain
    Helicobacter 9:681-9. 2004
    ..Platelet activation is consistently observed in animal models of Helicobacter pylori infection and could help to explain the alleged epidemiological association between H. pylori and coronary heart disease...
  50. ncbi request reprint Platelet 5-HT2A-receptor-mediated induction of aggregation is not altered in major depression
    Esther Gomez-Gil
    Instituto Clínic de Psiquiatría y Psicología, Hospital Clinic, Institut d Investigacions Biomediques August Pi i Sunyer IDIBAPS, Faculty of Medicine, University of Barcelona, Villaroel 170, 08036 Barcelona, Spain
    Hum Psychopharmacol 17:419-24. 2002
    ..However, their functional state has often been disregarded. The aim of the study was to investigate whether depressed patients show abnormalities in the function of the 5-HT(2A) receptor pathway in platelets...
  51. pmc Primary arrest of circulating platelets on collagen involves phosphorylation of Syk, cortactin and focal adhesion kinase: studies under flow conditions
    Gemma Arderiu
    Servei d Hemoterapia Hemostasia, Hospital Clinic, Institut de Investigacions Biomediques August Pi i Sunyer, Universitat de Barcelona, Spain
    Biochem J 364:65-71. 2002
    ..These processes seem to occur before GPIIb-IIIa becomes activated...
  52. ncbi request reprint G-CSF increases the expression of VCAM-1 on stromal cells promoting the adhesion of CD34+ hematopoietic cells: studies under flow conditions
    Berta Fuste
    Servicio de Hemoterapia Hemostasia, Hospital Clinic, IDIBAPS, Barcelona, Spain
    Exp Hematol 32:765-72. 2004
    ..We analyzed the impact of flow conditions on the adhesion of CD34+ peripheral blood progenitor cell (PBPC) to the adhesive proteins fibronectin, laminin, and collagen, and to stromal cells...
  53. ncbi request reprint Biocompatibility of cellulosic and synthetic membranes assessed by leukocyte activation
    Maria Rosa Hernandez
    Servei d Hemoterapia i Hemostasia, Hospital Clinic i Provincial, Barcelona, Spain
    Am J Nephrol 24:235-41. 2004
    ..We have investigated the effect of a hemodialysis (HD) with a cellulosic- and a synthetic-based membrane on circulating leukocyte activation...
  54. doi request reprint In vitro evaluation of the hemostatic effectiveness of cryopreserved platelets
    Joan Cid
    Department of Hemotherapy and Hemostasis, CDB, IDIBAPS, Hospital Clinic University of Barcelona, Barcelona, Spain
    Transfusion 56:580-6. 2016
    ..The objective of this study was to compare the in vitro hemostatic effect of CPP with fresh whole blood (WB) and standard 5-day PLT concentrates (PCs)...
  55. ncbi request reprint Phosphotyrosine proteins in platelets from patients with storage pool disease: direct relation between granule defects and defective signal transduction
    Gemma Arderiu
    Servei d Hemoterapia Hemostasia, Hospital Clinic, Universitat de Barcelona, Barcelona, Spain
    Haematologica 87:629-36. 2002
    ..We investigated signaling through tyrosine phosphorylation of proteins occurring in platelets with total or partial absence of dense- and alpha-granules in response to activation...
  56. ncbi request reprint Atomic force microscopy of liposomes bearing fibrinogen
    Elisenda Casals
    Departament de Fisicoquimica, Facultat de Farmacia, Universitat de Barcelona, Barcelona, Spain
    Bioconjug Chem 14:593-600. 2003
    ..The results clearly confirmed that fibrinogen bound covalently to liposomes...
  57. pmc NFκB in the development of endothelial activation and damage in uremia: an in vitro approach
    Carolina Caballo
    Hemotherapy Hemostasis Department, Centre de Diagnostic Biomedic, Institut d Investigacions Biomediques August Pi i Sunyer, Hospital Clinic, Universitat de Barcelona, Barcelona, Spain
    PLoS ONE 7:e43374. 2012
    ..Although peritoneal dialysis has been traditionally considered a more physiological technique, our results raise some doubts with respect to inflammation and EC damage...
  58. doi request reprint Defibrotide prevents the activation of macrovascular and microvascular endothelia caused by soluble factors released to blood by autologous hematopoietic stem cell transplantation
    Marta Palomo
    Hemotherapy Hemostasis Department, Centre de Diagnostic Biomedic, Institut d Investigacions Biomediques August Pi i Sunyer, Hospital Clinic, Universitat de Barcelona, Barcelona, Spain
    Biol Blood Marrow Transplant 17:497-506. 2011
    ....
  59. doi request reprint The release of soluble factors contributing to endothelial activation and damage after hematopoietic stem cell transplantation is not limited to the allogeneic setting and involves several pathogenic mechanisms
    Marta Palomo
    Hemotherapy Hemostasis Department, Centre de Diagnostic Biomedic, University of Barcelona, Barcelona, Spain
    Biol Blood Marrow Transplant 15:537-46. 2009
    ..Further studies are needed to explore the association between this endothelial damage and the vascular complications associated with HSCT...
  60. ncbi request reprint Mean platelet component as an indicator of platelet activation in foals and adult horses
    Didac Segura
    Servei de Medicina Interna Equina, Departament de Medicina i Cirurgia Animals, Facultat de Veterinaria, Universitat Autonoma de Barcelona, Barcelona, Spain
    J Vet Intern Med 21:1076-82. 2007
    ..Mean platelet component (MPC) is a new platelet variable, measured by modern commercial complete blood count analyzers, that is reduced during platelet activation in humans and small animals...
  61. ncbi request reprint Hormonal response to buspirone is not impaired in major depression
    Ricard Navinés
    Institut de Neurociencies, Hospital Clinic, Barcelona, Spain
    Hum Psychopharmacol 22:389-95. 2007
    ..Therefore, this study does not support the hypothesis of an altered postsynaptic 5-HT(1A) receptor function in major depression...
  62. doi request reprint Endothelin-1 levels predict endothelial progenitor cell mobilization after acute myocardial infarction
    Xavier Freixa
    Cardiology Department, Hospital Clinic, University of Barcelona, Spain
    Microvasc Res 82:177-81. 2011
    ..However, the relationship between them has never been assessed. The objective of the present study was to establish the relationship between ET-1, CEC, and EPC concentrations after ST-elevation myocardial infarction (STEMI)...
  63. ncbi request reprint Leukoreduced buffy coat-derived platelet concentrates photochemically treated with amotosalen HCl and ultraviolet A light stored up to 7 days: assessment of hemostatic function under flow conditions
    Miguel Lozano
    Department of Hemotherapy and Hemostasis, Hospital Clinic Provincial, University of Barcelona, Barcelona, Spain
    Transfusion 47:666-71. 2007
    ..Adhesion and aggregation of PLTs to injured vascular surfaces are critical aspects of PLT hemostatic function...
  64. doi request reprint TLR4 and NALP3 inflammasome in the development of endothelial dysfunction in uraemia
    Susana Martin-Rodriguez
    Department of Hemotherapy Hemostasis, Institut d Investigacions Biomediques August Pi i Sunyer IDIBAPS, Hospital Clinic, Universitat de Barcelona, Barcelona, Spain
    Eur J Clin Invest 45:160-9. 2015
    ..Potential involvement of mechanisms recognizing DAMP, such as TLR and inflammasomes, has been explored...
  65. doi request reprint Prothrombotic platelet phenotype in major depression: downregulation by antidepressant treatment
    Irene Lopez-Vilchez
    Department of Hemotherapy and Hemostasis, Hospital Clinic, Biomedical Diagnosis Centre, Institute of Biomedical Research August Pi i Sunyer, University of Barcelona, Barcelona, Spain Electronic address
    J Affect Disord 159:39-45. 2014
    ..We investigated the existence of a prothrombotic condition in depressed patients and its possible modulation during treatment with a selective serotonin-reuptake inhibitor (SSRI)...
  66. ncbi request reprint New insights into the management of bleeding disorders
    Gines Escolar
    Servicio de Hemoterapia y Hemostasia, CDB, Hospital Clinic, Barcelona, Spain
    Drug News Perspect 17:285-8. 2004
    ..Rationale for new clinical trials and updates on registry for emerging indications were also discussed...
  67. ncbi request reprint Effects of celecoxib and naproxen on renal function in nonazotemic patients with cirrhosis and ascites
    Joan Claria
    DNA Unit, Hospital Clinic, Institut d Investigacions Biomediques August Pi i Sunyer IDIBAPS, University of Barcelona, Barcelona, Spain
    Hepatology 41:579-87. 2005
    ..Further studies are needed to evaluate the long-term safety of this drug in cirrhosis...
  68. ncbi request reprint Effects of beta2-glycoprotein I and monoclonal anticardiolipin antibodies in platelet interaction with subendothelium under flow conditions
    Josep Font
    Hospital Clinic and Institut d Investigacions Biomèdiques August Pi i Sunyer, Barcelona, Spain
    Arthritis Rheum 46:3283-9. 2002
    ..To evaluate whether the effect of human monoclonal anticardiolipin antibodies (aCL) on platelet interaction with the subendothelium under flow conditions is dependent on beta(2)-glycoprotein I (beta(2)GPI)...
  69. pmc Inhibition of cytoskeletal assembly by cytochalasin B prevents signaling through tyrosine phosphorylation and secretion triggered by collagen but not by thrombin
    Maribel Diaz-Ricart
    Servei d Hemoterapia Hemostasia, Hospital Clinic, IDIBAPS, Universitat de Barcelona, Barcelona, Spain
    Am J Pathol 160:329-37. 2002
    ..Moreover, the expression of a procoagulant surface in platelets still occurs even when platelet motility has been inhibited...
  70. ncbi request reprint The hemostatic agent ethamsylate promotes platelet/leukocyte aggregate formation in a model of vascular injury
    Maria Rosa Hernandez
    Department of Hemotherapy and Hemostasis, Hospital Clinic, Barcelone, Spain
    Fundam Clin Pharmacol 18:423-30. 2004
    ..Res. (2002)107:329-335] confirms and extends the view that ethamsylate acts on the first step of hemostasis, by improving platelet homo- and heterotypic adhesiveness...
  71. doi request reprint Platelet transfusions from D+ donors to D- patients: a 10-year follow-up study of 1014 patients
    Joan Cid
    Hemotherapy and Hemostasis Department, Hospital Clinic, IDIBAPS, Barcelona, Spain
    Transfusion 51:1163-9. 2011
    ..We thus decided to extend these findings by examining anti-D alloimmunization at our institution, where PLT transfusions from D+ donors are transfused to D- patients because of logistic constraints...
  72. doi request reprint mTOR inhibition and erythropoiesis: microcytosis or anaemia?
    Fritz Diekmann
    Department of Nephrology and Kidney Transplantation, Laboratori Experimental de Nefrologia i Transplantament, Hospital Clinic, Barcelona, Spain
    Nephrol Dial Transplant 27:537-41. 2012
    ..The aim of this study was to evaluate the potential role of mammalian target of rapamycin (mTOR) inhibition in the development of anaemia and microcytosis in healthy animals and in human erythroid cultures in vitro...
  73. ncbi request reprint Isoform-specific quantification of endothelins in HUVEC culture supernatants by on-line high-performance liquid chromatography/electrospray mass spectrometry
    Montserrat Carrascal
    Structural and Biological Mass Spectrometry Unit, Department of Medical Bioanalysis, IIBB CSIC, IDIBAPS, Rossello 161, 08036 Barcelona, Spain
    Biomed Chromatogr 18:388-95. 2004
    ..Basal levels were determined to be 1.8 +/- 0.3 pmol/mL. Quantitative results obtained for ET1 were in agreement with those obtained by using a standard addition method and by an ELISA method...
  74. pmc Factor v leiden and inflammation
    Silvia Perez-Pujol
    Servicio de Hemoterapia y Hemostasia, Hospital Clinic, C Villarroel 170, 08036 Barcelona, Spain
    Thrombosis 2012:594986. 2012
    ....