Teresa M Coque

Summary

Country: Spain

Publications

  1. ncbi request reprint Increasing prevalence of ESBL-producing Enterobacteriaceae in Europe
    T M Coque
    Microbiology Department, University Hospital Ramon y Cajal, CIBER Epidemiology and Public Health, Madrid, Spain
    Euro Surveill 13:. 2008
  2. pmc Population structure of Enterococcus faecium causing bacteremia in a Spanish university hospital: setting the scene for a future increase in vancomycin resistance?
    Teresa M Coque
    Departamento de Microbiologíca, Servicio de Microbiologia, Hospital Universitario Ramon y Cajal, Carretera de Colmenar, Km 9 1, Madrid 28034, Spain
    Antimicrob Agents Chemother 49:2693-700. 2005
  3. pmc Dissemination of clonally related Escherichia coli strains expressing extended-spectrum beta-lactamase CTX-M-15
    Teresa M Coque
    Hospital Universitario Ramon y Cajal, Madrid, Spain
    Emerg Infect Dis 14:195-200. 2008
  4. pmc Dissemination and persistence of blaCTX-M-9 are linked to class 1 integrons containing CR1 associated with defective transposon derivatives from Tn402 located in early antibiotic resistance plasmids of IncHI2, IncP1-alpha, and IncFI groups
    Angela Novais
    Hospital Universitario Ramon y Cajal, IMSALUD, Madrid 28034, Spain
    Antimicrob Agents Chemother 50:2741-50. 2006
  5. doi request reprint Characterization of plasmids encoding blaESBL and surrounding genes in Spanish clinical isolates of Escherichia coli and Klebsiella pneumoniae
    Karol Diestra
    Servicio de Microbiologia, Hospital de la Santa Creu i Sant Pau, Barcelona, Spain
    J Antimicrob Chemother 63:60-6. 2009
  6. doi request reprint Emergence of bla KPC-3-Tn4401a associated with a pKPN3/4-like plasmid within ST384 and ST388 Klebsiella pneumoniae clones in Spain
    Tânia Curiao
    Servicio de Microbiologia, Hospital Universitario Ramon y Cajal, CIBER en Epidemiología y Salud Pública CIBERESP and Instituto Ramón y Cajal de Investigación Sanitaria IRYCIS, Madrid, Spain
    J Antimicrob Chemother 65:1608-14. 2010
  7. pmc Longer intestinal persistence of Enterococcus faecalis compared to Enterococcus faecium clones in intensive-care-unit patients
    Patricia Ruiz-Garbajosa
    Servicio de Microbiologia, Hospital Universitario Ramon y Cajal, Madrid, Spain
    J Clin Microbiol 47:345-51. 2009
  8. doi request reprint Multiclonal dispersal of KPC genes following the emergence of non-ST258 KPC-producing Klebsiella pneumoniae clones in Madrid, Spain
    Patricia Ruiz-Garbajosa
    Servicio de Microbiologia, Hospital Universitario Ramón y Cajal and Instituto Ramón y Cajal de Investigación Sanitaria IRYCIS, Madrid, Spain
    J Antimicrob Chemother 68:2487-92. 2013
  9. pmc Population analysis and epidemiological features of inhibitor-resistant-TEM-beta-lactamase-producing Escherichia coli isolates from both community and hospital settings in Madrid, Spain
    Oihane Martín
    Servicio de Microbiologia, Hospital Universitario Ramon y Cajal, Madrid, Spain
    J Clin Microbiol 48:2368-72. 2010
  10. pmc Global spread of the hyl(Efm) colonization-virulence gene in megaplasmids of the Enterococcus faecium CC17 polyclonal subcluster
    Ana R Freitas
    Servicio de Microbiologia, Hospital Universitario Ramon y Cajal, Carretera de Colmenar, Madrid 28034, Spain
    Antimicrob Agents Chemother 54:2660-5. 2010

Collaborators

Detail Information

Publications56

  1. ncbi request reprint Increasing prevalence of ESBL-producing Enterobacteriaceae in Europe
    T M Coque
    Microbiology Department, University Hospital Ramon y Cajal, CIBER Epidemiology and Public Health, Madrid, Spain
    Euro Surveill 13:. 2008
    ....
  2. pmc Population structure of Enterococcus faecium causing bacteremia in a Spanish university hospital: setting the scene for a future increase in vancomycin resistance?
    Teresa M Coque
    Departamento de Microbiologíca, Servicio de Microbiologia, Hospital Universitario Ramon y Cajal, Carretera de Colmenar, Km 9 1, Madrid 28034, Spain
    Antimicrob Agents Chemother 49:2693-700. 2005
    ..001). These findings reflect the importance of local environmental differences in the evolution of this CC, suggesting that the emergence of vancomycin resistance among AREF strains in Spain may be a question of time...
  3. pmc Dissemination of clonally related Escherichia coli strains expressing extended-spectrum beta-lactamase CTX-M-15
    Teresa M Coque
    Hospital Universitario Ramon y Cajal, Madrid, Spain
    Emerg Infect Dis 14:195-200. 2008
    ..Most plasmids contained blaOXA-1, aac(6')-Ib-cr, and blaTEM-1. Worldwide dissemination of CTX-M-15 seems to be determined by clonal complexes ST131 and ST405 and multidrug-resistant IncFII plasmids...
  4. pmc Dissemination and persistence of blaCTX-M-9 are linked to class 1 integrons containing CR1 associated with defective transposon derivatives from Tn402 located in early antibiotic resistance plasmids of IncHI2, IncP1-alpha, and IncFI groups
    Angela Novais
    Hospital Universitario Ramon y Cajal, IMSALUD, Madrid 28034, Spain
    Antimicrob Agents Chemother 50:2741-50. 2006
    ..The presence of bla(CTX-M-9) on broad-host-range IncP-1alpha plasmids might contribute to its dissemination to hosts that were not members of the family Enterobacteriaceae...
  5. doi request reprint Characterization of plasmids encoding blaESBL and surrounding genes in Spanish clinical isolates of Escherichia coli and Klebsiella pneumoniae
    Karol Diestra
    Servicio de Microbiologia, Hospital de la Santa Creu i Sant Pau, Barcelona, Spain
    J Antimicrob Chemother 63:60-6. 2009
    ..The aim of the study was to characterize plasmids that harbour blaESBL genes and their genetic environment in Escherichia coli and Klebsiella pneumoniae clones circulating in Spain...
  6. doi request reprint Emergence of bla KPC-3-Tn4401a associated with a pKPN3/4-like plasmid within ST384 and ST388 Klebsiella pneumoniae clones in Spain
    Tânia Curiao
    Servicio de Microbiologia, Hospital Universitario Ramon y Cajal, CIBER en Epidemiología y Salud Pública CIBERESP and Instituto Ramón y Cajal de Investigación Sanitaria IRYCIS, Madrid, Spain
    J Antimicrob Chemother 65:1608-14. 2010
    ..KPC carbapenemase-producing Klebsiella pneumoniae isolates have been increasingly detected in Europe. We report the first KPC-producing isolates characterized in Madrid, Spain...
  7. pmc Longer intestinal persistence of Enterococcus faecalis compared to Enterococcus faecium clones in intensive-care-unit patients
    Patricia Ruiz-Garbajosa
    Servicio de Microbiologia, Hospital Universitario Ramon y Cajal, Madrid, Spain
    J Clin Microbiol 47:345-51. 2009
    ..faecalis showed a cumulative increase in CDPD, whereas E. faecium did not. CDPD and CPR were useful for measuring the dynamics of intestinal colonization with enterococcal clones...
  8. doi request reprint Multiclonal dispersal of KPC genes following the emergence of non-ST258 KPC-producing Klebsiella pneumoniae clones in Madrid, Spain
    Patricia Ruiz-Garbajosa
    Servicio de Microbiologia, Hospital Universitario Ramón y Cajal and Instituto Ramón y Cajal de Investigación Sanitaria IRYCIS, Madrid, Spain
    J Antimicrob Chemother 68:2487-92. 2013
    ..To analyse the ongoing epidemiology of KPC-producing Enterobacteriaceae after a non-ST258 KPC-3-producing Klebsiella pneumoniae outbreak in a university hospital in Madrid, Spain...
  9. pmc Population analysis and epidemiological features of inhibitor-resistant-TEM-beta-lactamase-producing Escherichia coli isolates from both community and hospital settings in Madrid, Spain
    Oihane Martín
    Servicio de Microbiologia, Hospital Universitario Ramon y Cajal, Madrid, Spain
    J Clin Microbiol 48:2368-72. 2010
    ..Despite this situation, clonal expansion and/or gene dispersion was not observed, denoting the independent emergence of these enzymes...
  10. pmc Global spread of the hyl(Efm) colonization-virulence gene in megaplasmids of the Enterococcus faecium CC17 polyclonal subcluster
    Ana R Freitas
    Servicio de Microbiologia, Hospital Universitario Ramon y Cajal, Carretera de Colmenar, Madrid 28034, Spain
    Antimicrob Agents Chemother 54:2660-5. 2010
    ..faecium isolates with different origins...
  11. pmc Preservation of integron types among Enterobacteriaceae producing extended-spectrum beta-lactamases in a Spanish hospital over a 15-year period (1988 to 2003)
    Elisabete Machado
    Servicio de Microbiologia, Hospital Universitario Ramón y Cajal Carretera de Colmenar, km 9 1 Madrid 28034, Spain
    Antimicrob Agents Chemother 51:2201-4. 2007
    ..Some integrons were identical to those found during decades worldwide, illustrating the preservation of the genetic elements carrying them...
  12. doi request reprint Large clonal outbreak of multidrug-resistant CC17 ST17 Enterococcus faecium containing Tn5382 in a Spanish hospital
    Sylvia Valdezate
    Departamento de Bacteriologia, Centro Nacional de Microbiologia, Instituto de Salud Carlos III, Majadahonda, Madrid, Spain
    J Antimicrob Chemother 63:17-20. 2009
    ..A large clonal outbreak of multidrug-resistant CC17 ST17 Enterococcus faecium containing Tn5382 in a hospital in the north of Spain is described...
  13. doi request reprint Extended-spectrum beta-lactamase-producing Escherichia coli in Spain belong to a large variety of multilocus sequence typing types, including ST10 complex/A, ST23 complex/A and ST131/B2
    Jesús Oteo
    Laboratório de Antibióticos, Servicio de Bacteriologia, Centro Nacional de Microbiologia, Instituto de Salud Carlos III, Madrid, Spain
    Int J Antimicrob Agents 34:173-6. 2009
    ..coli ST10 complex carried five ESBLs and E. coli ST23 complex carried four ESBLs. A great diversity of MLST types was observed among Spanish ESBL-producing E. coli isolates...
  14. pmc International spread and persistence of TEM-24 is caused by the confluence of highly penetrating enterobacteriaceae clones and an IncA/C2 plasmid containing Tn1696::Tn1 and IS5075-Tn21
    Angela Novais
    Servicio de Microbiologia, Hospital Universitario Ramon y Cajal, Carretera de Colmenar, Km 9 1, Madrid 28034, Spain
    Antimicrob Agents Chemother 54:825-34. 2010
    ....
  15. pmc Antibiotic coresistance in extended-spectrum-beta-lactamase-producing Enterobacteriaceae and in vitro activity of tigecycline
    María Isabel Morosini
    Servicio de Microbiologia, Hospital Universitario Ramon y Cajal, 28034 Madrid, Spain
    Antimicrob Agents Chemother 50:2695-9. 2006
    ..However, this in vitro promise requires support from clinical studies...
  16. pmc Spread of bla(CTX-M-14) is driven mainly by IncK plasmids disseminated among Escherichia coli phylogroups A, B1, and D in Spain
    Aranzazu Valverde
    Servicio de Microbiologia, Hospital Universitario Ramon y Cajal, Madrid, Spain
    Antimicrob Agents Chemother 53:5204-12. 2009
    ..The increase in the incidence of such isolates is mostly due to the dissemination of IncK plasmids among E. coli isolates of phylogroups A, B1, and D...
  17. ncbi request reprint Complex molecular epidemiology of extended-spectrum beta-lactamases in Klebsiella pneumoniae: a long-term perspective from a single institution in Madrid
    Aranzazu Valverde
    Servicio de Microbiologia, Hospital Universitario Ramón y Cajal and CIBER ESP, Madrid, Spain
    J Antimicrob Chemother 61:64-72. 2008
    ..To analyse all extended-spectrum-beta-lactamase (ESBL)-producing Klebsiella pneumoniae isolates recovered from 2001 to 2004 in our institution and to compare this period with that of 1989 to 2000...
  18. pmc CTX-M-10 linked to a phage-related element is widely disseminated among Enterobacteriaceae in a Spanish hospital
    Antonio Oliver
    Servicio de Microbiologia, Hospital Son Dureta, C Andrea Doria No 55, 07014 Palma de Mallorca, Spain
    Antimicrob Agents Chemother 49:1567-71. 2005
    ..This is the first report showing an extended-spectrum-beta-lactamase gene linked to a phage-related element...
  19. ncbi request reprint The CTX-M beta-lactamase pandemic
    Rafael Canton
    Servicio de Microbiologia, Hospital Ramon y Cajal, 28034 Madrid, Spain
    Curr Opin Microbiol 9:466-75. 2006
    ..All these events might have contributed to the current pandemic CTX-M beta-lactamase scenario...
  20. doi request reprint Assessment of prevalence and changing epidemiology of extended-spectrum beta-lactamase-producing Enterobacteriaceae fecal carriers using a chromogenic medium
    Raquel Paniagua
    Servicio de Microbiologia, Hospital Universitario Ramón y Cajal and CIBER en Epidemiología y Salud Pública CIBERESP, Instituto de Investigación Ramón y Cajal IRYCIS, 28034 Madrid, Spain
    Diagn Microbiol Infect Dis 67:376-9. 2010
    ..The chromID ESBL medium was reliable to screen ESBL fecal carriers with a general decrease in the laboratory workload. Time-to-time monitoring of ESBL fecal carriers is useful to ascertain current trend of ESBL epidemiology...
  21. pmc High rate of intestinal colonization with extended-spectrum-beta-lactamase-producing organisms in household contacts of infected community patients
    Aranzazu Valverde
    Servicio de Microbiologia, Hospital Universitario Ramon y Cajal, 28034 Madrid, Spain
    J Clin Microbiol 46:2796-9. 2008
    ..Patients with community infections and members of their households represent a reservoir for ESBL producers, increasing dispersal of resistance in healthy people...
  22. pmc Fecal carriage of carbapenemase-producing Enterobacteriaceae: a hidden reservoir in hospitalized and nonhospitalized patients
    Desirèe Gijón
    Servicio de Microbiología and CIBER en Epidemiología y Salud Pública and Instituto Ramón y Cajal de Investigación Sanitaria, Madrid, Spain
    J Clin Microbiol 50:1558-63. 2012
    ..Dissemination of bla(VIM-1) class-1 integrons within highly transferable plasmids in a polyclonal population has potentially contributed to the maintenance and spread of CPE...
  23. pmc Mutational events in cefotaximase extended-spectrum beta-lactamases of the CTX-M-1 cluster involved in ceftazidime resistance
    Angela Novais
    Hospital Universitario Ramon y Cajal, IMSALUD, Madrid, Spain
    Antimicrob Agents Chemother 52:2377-82. 2008
    ..This suggests that in this context this mutation might be considered a primary site involved in resistance to broad-spectrum cephalosporins...
  24. pmc Integron content of extended-spectrum-beta-lactamase-producing Escherichia coli strains over 12 years in a single hospital in Madrid, Spain
    Elisabete Machado
    Hospital Universitario Ramon y Cajal, IMSALUD, Madrid 28034, Spain
    Antimicrob Agents Chemother 49:1823-9. 2005
    ....
  25. pmc Evolutionary trajectories of beta-lactamase CTX-M-1 cluster enzymes: predicting antibiotic resistance
    Angela Novais
    Hospital Universitario Ramon y Cajal, IMSALUD, Madrid, Spain
    PLoS Pathog 6:e1000735. 2010
    ....
  26. pmc Association of composite IS26-sul3 elements with highly transmissible IncI1 plasmids in extended-spectrum-beta-lactamase-producing Escherichia coli clones from humans
    Tânia Curiao
    Servicio de Microbiologia, IRYCIS, Madrid, Spain
    Antimicrob Agents Chemother 55:2451-7. 2011
    ....
  27. pmc Emergence and dissemination of Enterobacteriaceae isolates producing CTX-M-1-like enzymes in Spain are associated with IncFII (CTX-M-15) and broad-host-range (CTX-M-1, -3, and -32) plasmids
    Angela Novais
    Servicio de Microbiologia, Hospital Universitario Ramon y Cajal, IMSALUD, Carretera de Colmenar, Km 9 1, Madrid 28034, Spain
    Antimicrob Agents Chemother 51:796-9. 2007
    ..The identical genetic surroundings of blaCTX-M-32 and blaCTX-M-1 and their locations on related 40-kb IncN plasmids indicate the in vivo evolution of this element...
  28. pmc Contribution of IncFII and broad-host IncA/C and IncN plasmids to the local expansion and diversification of phylogroup B2 Escherichia coli ST131 clones carrying blaCTX-M-15 and qnrS1 genes
    Angela Novais
    Servicio de Microbiología and CIBER en Epidemiología y Salud Pública, Instituto Ramón y Cajal de Investigación Sanitaria and Hospital Universitario Ramón y Cajal, Madrid, Spain
    Antimicrob Agents Chemother 56:2763-6. 2012
    ....
  29. pmc Dispersal of carbapenemase blaVIM-1 gene associated with different Tn402 variants, mercury transposons, and conjugative plasmids in Enterobacteriaceae and Pseudomonas aeruginosa
    Marta Tato
    Servicio de Microbiologia, Hospital Universitario Ramon y Cajal, Carretera de Colmenar, Km 9 1, Madrid 28034, Spain
    Antimicrob Agents Chemother 54:320-7. 2010
    ..Knowledge of the complex epidemiology of bla(VIM-1) is necessary to control this emerging threat...
  30. pmc Dramatic increase in prevalence of fecal carriage of extended-spectrum beta-lactamase-producing Enterobacteriaceae during nonoutbreak situations in Spain
    Aranzazu Valverde
    Servicio de Microbiologia, Hospital Universitario Ramon y Cajal, Madrid, Spain
    J Clin Microbiol 42:4769-75. 2004
    ....
  31. pmc Epidemiology of extended-spectrum beta-lactamase-producing Enterobacter isolates in a Spanish hospital during a 12-year period
    Rafael Canton
    Servicio de Microbiología Hospital Ramón y Cajal, Madrid, Spain
    J Clin Microbiol 40:1237-43. 2002
    ..The presence of the TEM-24-producing E. aerogenes French clone in our institution also demonstrates the intercountry dissemination of ESBL-producing isolates...
  32. pmc In117, an unusual In0-like class 1 integron containing CR1 and bla(CTX-M-2) and associated with a Tn21-like element
    Aranzazu Valverde
    Hospital Universitario Ramon y Cajal, IMSALUD, Madrid, Spain
    Antimicrob Agents Chemother 50:799-802. 2006
    ..This element constitutes one of the few examples of CR1-bearing class 1 integrons that has been fully characterized...
  33. pmc Multilocus sequence typing scheme for Enterococcus faecalis reveals hospital-adapted genetic complexes in a background of high rates of recombination
    Patricia Ruiz-Garbajosa
    Servicio de Microbiologia, Hospital Universitario Ramon y Cajal, Madrid, Spain
    J Clin Microbiol 44:2220-8. 2006
    ..faecalis. Our novel MLST scheme provides an excellent tool for investigating local and short-term epidemiology as well as global epidemiology, population structure, and genetic evolution of E. faecalis...
  34. ncbi request reprint Risk factors associated with ampicillin resistance in patients with bacteraemia caused by Enterococcus faecium
    Jesus Fortun
    Department of Infectious Diseases, Ramon y Cajal Hospital, University of Alcala, Crtra Colmenar Km 9 1, Madrid 28034, Spain
    J Antimicrob Chemother 50:1003-9. 2002
    ..Bacteraemia caused by ampicillin-resistant enterococci was not associated with increased mortality when compared with bacteraemias caused by ampicillin-susceptible strains...
  35. pmc Multiple adaptive routes of Salmonella enterica Typhimurium to biocide and antibiotic exposure
    Tânia Curiao
    Servicio de Microbiologia, Instituto Ramón y Cajal de Investigación Sanitaria IRYCIS, Madrid, Spain
    BMC Genomics 17:491. 2016
    ....
  36. ncbi request reprint High occurrence of esp among ampicillin-resistant and vancomycin-susceptible Enterococcus faecium clones from hospitalized patients
    Teresa M Coque
    Servicio de Microbiologia, Hospital Ramon y Cajal, Carretera de Colmenar, Km 9 1, Madrid 28034, Spain
    J Antimicrob Chemother 50:1035-8. 2002
    ..faecium clones. This observation indicates that antibiotic-resistant variants may frequently arise under antibiotic selective pressure among esp-positive clones reaching ecological abundance in the nosocomial habitat...
  37. ncbi request reprint Long-term clonal dynamics of Enterococcus faecium strains causing bloodstream infections (1995-2015) in Spain
    Ana P Tedim
    Microbiology Department, Hospital Universitario Ramon y Cajal, Instituto Ramón y Cajal de Investigación Sanitaria IRYCIS, Madrid, Spain Unidad de Resistencia a Antibióticos y Virulencia Bacteriana Asociada al Consejo Superior de Investigaciones Científicas CSIC, Madrid, Spain Centros de Investigación Biomédica en Red de Epidemiología y Salud Pública CIBER ESP, Barcelona, Spain
    J Antimicrob Chemother . 2016
    ....
  38. pmc Antibiotic-resistant Klebsiella pneumoniae and Escherichia coli high-risk clones and an IncFII(k) mosaic plasmid hosting Tn1 (blaTEM-4) in isolates from 1990 to 2004
    Irene Rodríguez
    Servicio de Microbiologia, Hospital Universitario Ramón y Cajal and Instituto Ramón y Cajal de Investigación Sanitaria IRYCIS, Madrid, Spain CIBER en Epidemiología y Salud Pública CIBERESP, Madrid, Spain
    Antimicrob Agents Chemother 59:2904-8. 2015
    ..Predominant populations of plasmids and host adapted clonal lineages seem to have greatly contributed to the spread of resistance to extended-spectrum cephalosporins...
  39. pmc Genes encoding TEM-4, SHV-2, and CTX-M-10 extended-spectrum beta-lactamases are carried by multiple Klebsiella pneumoniae clones in a single hospital (Madrid, 1989 to 2000)
    Teresa M Coque
    Servicio de Microbiologia, Hospital Ramon y Cajal, Madrid, Spain
    Antimicrob Agents Chemother 46:500-10. 2002
    ....
  40. pmc Increased mutation frequencies in Escherichia coli isolates harboring extended-spectrum beta-lactamases
    Maria Rosario Baquero
    Department of Microbiology, Ramon y Cajal University Hospital, Madrid, Spain
    Antimicrob Agents Chemother 49:4754-6. 2005
    ..coli (26%) strains (P = 0.03). Among urinary tract isolates, the frequency of hypermutation was 40% in ESBL versus 26% in non-ESBL isolates (P = 0.03)...
  41. pmc Dissemination of blaKPC-2 by the spread of Klebsiella pneumoniae clonal complex 258 clones (ST258, ST11, ST437) and plasmids (IncFII, IncN, IncL/M) among Enterobacteriaceae species in Brazil
    Leonardo Neves Andrade
    Faculdade de Ciencias Farmaceuticas de Ribeirao Preto, Universidade de Sao Paulo, Ribeirao Preto, Brazil
    Antimicrob Agents Chemother 55:3579-83. 2011
    ..It also constitutes the first description of sequence type 258 (ST258) in Brazil, which was associated with a nosocomial hospital outbreak in Ribeirao Preto city...
  42. pmc Human and swine hosts share vancomycin-resistant Enterococcus faecium CC17 and CC5 and Enterococcus faecalis CC2 clonal clusters harboring Tn1546 on indistinguishable plasmids
    Ana R Freitas
    REQUIMTE, Laboratorio de Microbiologia, Faculdade de Farmacia, Universidade do Porto, Porto, Portugal
    J Clin Microbiol 49:925-31. 2011
    ..The results indicate a current intra- and international spread of E. faecium and E. faecalis clones and their plasmids among swine and humans...
  43. ncbi request reprint [Characterization and molecular epidemiology of ESBL in Escherichia coli and Klebsiella pneumoniae in 11 Spanish hospitals (2004)]
    Karol Diestra
    Servicio de Microbiologı a, Hospital de la Santa Creu i Sant Pau, Departament de Gen etica i Microbiologia, Universitat Autonoma de Barcelona, Bellaterra, Cerdanyola del Valles, Barcelona, Spain
    Enferm Infecc Microbiol Clin 26:404-10. 2008
    ..The epidemiological distribution of extended-spectrum beta-lactamase (ESBL) types in Escherichia coli and Klebsiella pneumoniae was evaluated in various hospitals in Spain and compared with previous studies...
  44. doi request reprint Genomic and metagenomic technologies to explore the antibiotic resistance mobilome
    Jose L Martinez
    Centro Nacional de Biotecnologia, CSIC, Darwin 3, Madrid, Spain
    Ann N Y Acad Sci . 2016
    ....
  45. pmc Population biology of intestinal enterococcus isolates from hospitalized and nonhospitalized individuals in different age groups
    Ana P Tedim
    Servicio de Microbiologia, Hospital Universitario Ramon y Cajal, Instituto Ramón y Cajal de Investigación Sanitaria IRYCIS, Madrid, Spain Unidad de Resistencia a Antibióticos y Virulencia Bacteriana Asociada al Consejo Superior de Investigaciones Científicas CSIC, Madrid, Spain Centros de Investigación Biomédica en Red de Epidemiología y Salud Pública CIBER ESP, Madrid, Spain
    Appl Environ Microbiol 81:1820-31. 2015
    ..faecium populations from hospitalized patients and from community-based individuals differ, with a predominance of certain clonal lineages, often in association with elderly individuals, occurring in the hospital setting. ..
  46. ncbi request reprint [High-risk clonal complexes CC2 and CC9 are widely distributed among Enterococcus faecalis hospital isolates recovered in Spain]
    Patricia Ruiz-Garbajosa
    Servicio de Microbiología Hospital Universitario Ramón y Cajal Madrid España
    Enferm Infecc Microbiol Clin 25:513-8. 2007
    ..The purpose of this study was to define the presence of CC2 and CC9 among E. faecalis strains isolated in Spain...
  47. pmc Diversity and Evolution of the Tn5801-tet(M)-Like Integrative and Conjugative Elements among Enterococcus, Streptococcus, and Staphylococcus
    Ricardo León-Sampedro
    Servicio de Microbiologia, Hospital Universitario Ramon y Cajal, Madrid, Spain CIBER Epidemiología y Salud Pública, Madrid, Spain
    Antimicrob Agents Chemother 60:1736-46. 2016
    ..Horizontal transfer, also demonstrated, could explain the variability observed, with the isolates often containing sequences of different origins. ..
  48. pmc Polymorphic variation in susceptibility and metabolism of triclosan-resistant mutants of Escherichia coli and Klebsiella pneumoniae clinical strains obtained after exposure to biocides and antibiotics
    Tânia Curiao
    Servicio de Microbiologia, Instituto Ramón y Cajal de Investigación Sanitaria IRYCIS, Madrid, Spain CIBER Epidemiología y Salud Pública CIBERESP, Madrid, Spain
    Antimicrob Agents Chemother 59:3413-23. 2015
    ..These various phenotypes suggest a trade-off of different selective processes shaping the evolution toward antibiotic/biocide resistance and influencing other adaptive traits...
  49. ncbi request reprint Allodemics
    Fernando Baquero
    Department of Microbiology, Ramon y Cajal University Hospital, Madrid, Spain
    Lancet Infect Dis 2:591-2. 2002
  50. pmc Ecology and evolution as targets: the need for novel eco-evo drugs and strategies to fight antibiotic resistance
    Fernando Baquero
    Department of Microbiology, Institute Ramón and Cajal for Health Research IRYCIS, CIBER Research Network in Epidemiology and Public Health CIBERESP, Ramon y Cajal University Hospital, Madrid, Spain
    Antimicrob Agents Chemother 55:3649-60. 2011
    ..Eco-evo drugs and interventions constitute a new avenue for research that might influence not only antibiotic resistance but the maintenance of a healthy interaction between humans and microbial systems in a rapidly changing biosphere...
  51. ncbi request reprint AccNET (Accessory Genome Constellation Network): Comparative genomics software for accessory genome analysis using bipartite networks
    Val F Lanza
    Department of Microbiology, Ramon y Cajal University Hospital, Ramón y Cajal Health Research Institute IRYCIS, Madrid, Spain, Join Unit of Antibiotic Resistance and Bacterial Virulence associated with the Spanish National Research Council CSIC, CIBER in Epidemiology and Public Health CIBER ESP, Madrid, Spain
    Bioinformatics . 2016
    ..The AccNET bipartite network opens a new perspective to explore the pangenome of bacterial species, focusing on the accessory genome behind the idiosyncrasy of a particular strain and/or population...
  52. pmc A membrane computing simulator of trans-hierarchical antibiotic resistance evolution dynamics in nested ecological compartments (ARES)
    Marcelino Campos
    Department of Microbiology, Ramon y Cajal University Hospital, IRYCIS, Carretera de Colmenar Viejo, Km 9, 100, 28034, Madrid, Spain
    Biol Direct 10:41. 2015
    ....
  53. pmc Antibiotic resistance shaping multi-level population biology of bacteria
    Fernando Baquero
    Department of Microbiology, Hospital Universitario Ramon y Cajal, Instituto Ramón y Cajal de Investigación Sanitaria Madrid, Spain Centros de Investigación Biomédica en Red de Epidemiología y Salud Pública Madrid, Spain Unidad de Resistencia a Antibióticos y Virulencia Bacteriana Asociada al Consejo Superior de Investigaciones Científicas Madrid, Spain
    Front Microbiol 4:15. 2013
    ..The understanding of antibiotic resistance implies expanding our knowledge on multi-level population biology of bacteria...
  54. ncbi request reprint Multi-resistant Gram-negative bacilli: from epidemics to endemics
    Rafael Canton
    Department of Microbiology, Ramon y Cajal University Hospital, Madrid, Spain
    Curr Opin Infect Dis 16:315-25. 2003
    ..This review focuses on recent data that may help to understand the emergence and dissemination of multi-drug resistant bacilli and the current trend from epidemic to endemic situations...
  55. doi request reprint What is a resistance gene? Ranking risk in resistomes
    Jose L Martinez
    Departamento de Biotecnologia Microbiana, Centro Nacional de Biotecnologia, Consejo Superior de Investigaciones Cientificas CSIC, Darwin 3, Cantoblanco, Madrid 28049, Spain and the Unidad de Resistencia a Antibióticos y Virulencia Bacteriana asociada al Consejo Superior de Investigaciones Científicas CSIC, Madrid, Spain
    Nat Rev Microbiol 13:116-23. 2015
    ....
  56. pmc Widening the spaces of selection: evolution along sublethal antimicrobial gradients
    Fernando Baquero
    Department of Microbiology, Ramon y Cajal University Hospital, IRYCIS, CIBERESP, Madrid, Spain
    MBio 5:e02270. 2014
    ..Probably very small inhibitor concentrations in the environment, including in sewage and other water bodies, are sufficient to ensure the maintenance and spread of this kind of multiresistance plasmid. ..