Luis Castano

Summary

Country: Spain

Publications

  1. pmc Permanent neonatal diabetes caused by creation of an ectopic splice site within the INS gene
    Intza Garin
    Endocrinology and Diabetes Research Group, Hospital de Cruces, Universitat Politècnica de València Euskal Herriko Unibertsitateko, Barakaldo, Bizkaia, Spain
    PLoS ONE 7:e29205. 2012
  2. ncbi Prospective population screening for celiac disease: high prevalence in the first 3 years of life
    Luis Castano
    Endocrinology and Diabetes Research and Pediatric Units, Barakaldo, Spain
    J Pediatr Gastroenterol Nutr 39:80-4. 2004
  3. ncbi No association of CTLA4 gene with celiac disease in the Basque population
    Ainhoa Martin-Pagola
    Endocrinology and Diabetes Research, Hospital de Cruces, Barakaldo, Spain
    J Pediatr Gastroenterol Nutr 37:142-5. 2003
  4. doi Haploinsufficiency at GCK gene is not a frequent event in MODY2 patients
    Intza Garin
    Endocrinology and Diabetes Research Group, Hospital de Cruces, Barakaldo, Basque Country, Spain
    Clin Endocrinol (Oxf) 68:873-8. 2008
  5. ncbi MICA response to gliadin in intestinal mucosa from celiac patients
    Ainhoa Martin-Pagola
    Endocrinology and Diabetes Research Unit, Hospital de Cruces, Barakaldo, Bizkaia, Spain
    Immunogenetics 56:549-54. 2004
  6. ncbi HLA-DRB1 and MICA in autoimmunity: common associated alleles in autoimmune disorders
    J Ramón Bilbao
    Endocrinology and Diabetes Research Group, Hospital de Cruces, Barakaldo, Basque Country, Spain
    Ann N Y Acad Sci 1005:314-8. 2003
  7. ncbi Analysis of the expression of MICA in small intestinal mucosa of patients with celiac disease
    Ainhoa Martin-Pagola
    Endocrinology and Diabetes Research Units, Hospital de Cruces, Barakaldo, Bizkaia, Spain
    J Clin Immunol 23:498-503. 2003
  8. ncbi No evidence of association of CTLA4 polymorphisms with Addison's disease
    Guiomar Perez de Nanclares
    Endocrinology and Diabetes Research Unit, Hospital de Cruces, Barakaldo, Bizkaia, Spain
    Autoimmunity 37:453-6. 2004
  9. doi Absence of diabetes mellitus type 2 in obese children and adolescents in the north of Spain
    Anibal Aguayo
    Cruces University Hospital, Barakaldo, Spain
    J Pediatr Endocrinol Metab 26:25-9. 2013
  10. pmc Accuracy in copy number calling by qPCR and PRT: a matter of DNA
    Nora Fernandez-Jimenez
    Immunogenetics Research Laboratory, Cruces University Hospital, Barakaldo, Basque Country, Spain
    PLoS ONE 6:e28910. 2011

Collaborators

  • Cristina Camarero
  • Jordi Mesa
  • L Santos
  • S Gaztambide
  • A Rodriguez
  • Lorna W Harries
  • Atilano Carcavilla
  • Jose Ramon Bilbao
  • F Rivas
  • M Boronat
  • Luis Rodrigo
  • P Martul
  • B Garcia Cuartero
  • L Forga
  • Maria Esteve
  • M Oyarzabal
  • M A Rodriguez
  • José Antonio Garrote
  • Guiomar Perez de Nanclares
  • Gustavo Pérez-Nanclares
  • Ainhoa Martin-Pagola
  • Teresa Velayos
  • Juan Carlos Vitoria
  • Intza Garin
  • Itxaso Rica
  • Ainara Castellanos-Rubio
  • Inés Urrutia
  • Izortze Santin
  • Anibal Aguayo
  • Leticia Plaza-Izurieta
  • Nora Fernandez-Jimenez
  • Inaki Irastorza
  • Eduardo Fernandez-Rebollo
  • Rosa Martinez
  • Idoia Martínez de LaPiscina
  • Itziar Estalella
  • Virginia Bellido
  • Nuria Valdés
  • Raquel Barrio
  • Oihana Belar
  • Galder Gutierrez
  • Lourdes Ortiz
  • Gustavo Pérez de Nanclares
  • Maria Angeles Busturia
  • Idoia Hualde
  • Jose Ignacio San Pedro
  • Begona Calvo
  • Tamara Lopez-Euba
  • Koldo Garcia-Etxebarria
  • Federico Vazquez
  • Milagros Alonso
  • Rafael Martinez-Conde
  • Ihintza Larrañaga
  • Maite Guimón
  • Asier Eguia
  • Victoria Alcázar
  • Amaya Vela
  • Elena Navarro
  • Cristina Lamas
  • Manuel Muñoz-Torres
  • Javier Tebar
  • Anna Casteràs
  • Javier Nunez
  • Concepción Fernández
  • Amaia Vela
  • Gema Grau
  • Angeles Aniel-Quiroga
  • Elizabeth Blarduni
  • Elena Gastaldo
  • Oscar Rubio-Cabezas
  • Carmen de la Hoz
  • Eduardo Arranz
  • Pere Vilar
  • Carlos Lóez-Larrea
  • María Antonia Ramos-Arroyo
  • Felix Sanchez-Valverde
  • Antonio Lóez-Váquez
  • Laura Pardo
  • Blanca Hernandez
  • Pablo Oliver
  • Teresa Marques
  • Zuriñe García
  • Montserrat Alsina
  • Carme Farré
  • J Cedeno
  • F Aleixandre
  • M Rodríguez Rigual
  • A Cortazar
  • A Vela
  • C Luzuriaga

Detail Information

Publications24

  1. pmc Permanent neonatal diabetes caused by creation of an ectopic splice site within the INS gene
    Intza Garin
    Endocrinology and Diabetes Research Group, Hospital de Cruces, Universitat Politècnica de València Euskal Herriko Unibertsitateko, Barakaldo, Bizkaia, Spain
    PLoS ONE 7:e29205. 2012
    ..The aim of this study was to characterize the genetic etiology in a patient who presented with permanent neonatal diabetes at 2 months of age...
  2. ncbi Prospective population screening for celiac disease: high prevalence in the first 3 years of life
    Luis Castano
    Endocrinology and Diabetes Research and Pediatric Units, Barakaldo, Spain
    J Pediatr Gastroenterol Nutr 39:80-4. 2004
    ..It has been proposed that silent CD be diagnosed as soon as possible to avoid potential complications...
  3. ncbi No association of CTLA4 gene with celiac disease in the Basque population
    Ainhoa Martin-Pagola
    Endocrinology and Diabetes Research, Hospital de Cruces, Barakaldo, Spain
    J Pediatr Gastroenterol Nutr 37:142-5. 2003
    ..AIM To determine the contribution of two polymorphisms of the CTLA4 to the disease: the A/G dimorphism at position +49 in exon 1 and the (AT)(n) microsatellite in the 3' untranslated region...
  4. doi Haploinsufficiency at GCK gene is not a frequent event in MODY2 patients
    Intza Garin
    Endocrinology and Diabetes Research Group, Hospital de Cruces, Barakaldo, Basque Country, Spain
    Clin Endocrinol (Oxf) 68:873-8. 2008
    ....
  5. ncbi MICA response to gliadin in intestinal mucosa from celiac patients
    Ainhoa Martin-Pagola
    Endocrinology and Diabetes Research Unit, Hospital de Cruces, Barakaldo, Bizkaia, Spain
    Immunogenetics 56:549-54. 2004
    ....
  6. ncbi HLA-DRB1 and MICA in autoimmunity: common associated alleles in autoimmune disorders
    J Ramón Bilbao
    Endocrinology and Diabetes Research Group, Hospital de Cruces, Barakaldo, Basque Country, Spain
    Ann N Y Acad Sci 1005:314-8. 2003
    ..Some alleles are part of conserved haplotypes (A5.1-DR3, A5.1-DR2), whereas others seem to have independent effect (A9) and support the idea of two independent loci in this region...
  7. ncbi Analysis of the expression of MICA in small intestinal mucosa of patients with celiac disease
    Ainhoa Martin-Pagola
    Endocrinology and Diabetes Research Units, Hospital de Cruces, Barakaldo, Bizkaia, Spain
    J Clin Immunol 23:498-503. 2003
    ..With these results, we conclude that overexpression of MICA does not seem to play an important role in the pathogenesis of CD, at least at the time of diagnosis...
  8. ncbi No evidence of association of CTLA4 polymorphisms with Addison's disease
    Guiomar Perez de Nanclares
    Endocrinology and Diabetes Research Unit, Hospital de Cruces, Barakaldo, Bizkaia, Spain
    Autoimmunity 37:453-6. 2004
    ..The cytotoxic T lymphocyte-associated antigen 4 (CTLA4) gene encodes a receptor involved in the control of T cell proliferation and mediates T cell apoptosis...
  9. doi Absence of diabetes mellitus type 2 in obese children and adolescents in the north of Spain
    Anibal Aguayo
    Cruces University Hospital, Barakaldo, Spain
    J Pediatr Endocrinol Metab 26:25-9. 2013
    ..The worldwide epidemic of childhood obesity has been accompanied by an increase in the incidence of carbohydrate metabolism disorders...
  10. pmc Accuracy in copy number calling by qPCR and PRT: a matter of DNA
    Nora Fernandez-Jimenez
    Immunogenetics Research Laboratory, Cruces University Hospital, Barakaldo, Basque Country, Spain
    PLoS ONE 6:e28910. 2011
    ..The use of normalized, high quality genomic DNA yields comparable results with both methods...
  11. doi Revisiting genome wide association studies (GWAS) in coeliac disease: replication study in Spanish population and expression analysis of candidate genes
    Leticia Plaza-Izurieta
    Endocrinology Diabetes and Nutrition Research Group, Hospital de Cruces, Barakaldo, Spain
    J Med Genet 48:493-6. 2011
    ..Recent genome wide association studies (GWAS) on coeliac disease (CD) have identified risk loci harbouring genes that fit the accepted pathogenic model and are considered aetiological candidates...
  12. doi An Activating Mutation in STAT3 Results in Neonatal Diabetes through Reduced Insulin Synthesis
    Teresa Velayos
    Endocrinology and Diabetes Research Group, Hospital Universitario Cruces, BioCruces, CIBERDEM, CIBERER, UPV EHU, Barakaldo, Basque Country, Spain
    Diabetes . 2017
    ..The present findings represent the first functional indication of a direct link between a NDM-linked activating mutation in STAT3 and pancreatic β cell dysfunction...
  13. ncbi Immunoglobulin G autoantibodies against tissue-transglutaminase. A sensitive, cost-effective assay for the screening of celiac disease
    J Ramón Bilbao
    Diabetes Research Unit, Hospital de Cruces, Barakaldo, Basque Country, Spain
    Autoimmunity 35:255-9. 2002
    ....
  14. ncbi Mutations in GCK and HNF-1alpha explain the majority of cases with clinical diagnosis of MODY in Spain
    Itziar Estalella
    Endocrinology and Diabetes Research Group, Hospital de Cruces, Barakaldo, Basque Country, Spain
    Clin Endocrinol (Oxf) 67:538-46. 2007
    ..The aim of this study was to group patients with MODY (maturity-onset diabetes of the young) according to the genetic alterations underlying the disease and to investigate their clinical characteristics...
  15. ncbi 5'-Insulin gene VNTR polymorphism is specific for type 1 diabetes: no association with celiac or Addison's disease
    Guiomar Perez de Nanclares
    Endocrinology and Diabetes Research Unit, Hospital de Cruces, Barakaldo, Basque Country, Spain
    Ann N Y Acad Sci 1005:319-23. 2003
    ..92; 95% CI, 1.03-3.6). In conclusion, INS-VNTR does not seem to be involved in the susceptibility to autoimmune diseases other than T1DM and can be considered a diabetes-specific locus...
  16. ncbi No association of TLR2 and TLR4 polymorphisms with type I diabetes mellitus in the Basque population
    Izortze Santin
    Endocrinology and Diabetes Research Group, Hospital de Cruces, Barakaldo, University of the Basque Country, Bilbao, E48903 Bizkaia, Spain
    Ann N Y Acad Sci 1079:268-72. 2006
    ..The differences in TLR4 haplotype transmission to affected and unaffected offspring are indicative of a possible implication of TLR4 in disease risk but differences did not reach statistical significance...
  17. doi Long-term and acute effects of gliadin on small intestine of patients on potentially pathogenic networks in celiac disease
    Ainara Castellanos-Rubio
    Hospital de Cruces, Barakaldo, Bizkaia, Spain
    Autoimmunity 43:131-9. 2010
    ....
  18. pmc Lower Frequency of HLA-DRB1 Type 1 Diabetes Risk Alleles in Pediatric Patients with MODY
    Inés Urrutia
    BioCruces Health Research Institute, Cruces University Hospital, UPV EHU, CIBERDEM, CIBERER, Barakaldo, Spain
    PLoS ONE 12:e0169389. 2017
    ..The aim of this study was to determine the frequency of susceptible HLA-DRB1 alleles for type 1 diabetes in a cohort of pediatric patients with a confirmed genetic diagnosis of MODY...
  19. doi A Novel Mutation in a Patient with Hyperparathyroidism-Jaw Tumour Syndrome
    Virginia Bellido
    Department of Endocrinology, Cruces University Hospital, Plaza de Cruces s n, 48903, Barakaldo, Vizcaya, Spain
    Endocr Pathol 27:142-6. 2016
    ..It also highlights the fact that HPT-JT should be considered and CDC73 mutation analysis should be performed in cases of early-onset PHPT associated with ossifying fibromas of the jaw. ..
  20. doi Novel mutations in MEN1, CDKN1B and AIP genes in patients with multiple endocrine neoplasia type 1 syndrome in Spain
    Oihana Belar
    Endocrinology Research Group, Cruces Hospital, CIBERER, Barakaldo, Bizkaia, Spain
    Clin Endocrinol (Oxf) 76:719-24. 2012
    ..Not all patients with MEN1 phenotype present a defect in this gene. Thus, other genes like CDKN and AIP have been showed to be involved in MEN1-like patients...
  21. doi RET Cys634Arg mutation confers a more aggressive multiple endocrine neoplasia type 2A phenotype than Cys634Tyr mutation
    Nuria Valdés
    Department of Endocrinology and NutritionHospital Universitario Central de Asturias, Avenida de Roma s n, E 33011 Oviedo, Asturias, SpainDepartment of Endocrinology and NutritionHospital Universitario Virgen del Rocío, Sevilla, SpainDepartment of Endocrinology and NutritionHospital de Vall d Hebron, Barcelona, SpainDepartment of Endocrinology and NutritionHospital Severo Ochoa, Madrid, SpainDepartment of Endocrinology and NutritionComplejo Hospitalario Universitario de Albacete, Albacete, SpainDepartment of Endocrinology and NutritionHospital Universitario Virgen de la Arrixaca, Murcia, SpainEndocrinology and Diabetes Research GroupDepartment of Endocrinology and NutritionHospital Universitario de Cruces, Barakaldo, SpainDepartment of EndocrinologyComplejo Hospitalario de Navarra, Pamplona, Spain
    Eur J Endocrinol 172:301-7. 2015
    ..We aimed to analyse differences in clinical risk profiles and outcomes among different amino acids encoded by codon 634...
  22. pmc Pseudohypoparathyroidism type Ib associated with novel duplications in the GNAS locus
    Gustavo Pérez-Nanclares
    Endocrinology and Diabetes Research Group, Hospital Universitario Cruces, BioCruces, CIBERER, CIBERDEM, UPV EHU, Barakaldo, Basque Country, Spain
    PLoS ONE 10:e0117691. 2015
    ..Whereas familial PHP-Ib is well characterized at the molecular level, the genetic cause of sporadic PHP-Ib cases remains elusive, although some molecular mechanisms have been associated with this subtype...
  23. doi New mutation type in pseudohypoparathyroidism type Ia
    Eduardo Fernandez-Rebollo
    Endocrinology and Diabetes Research Group, Hospital de Cruces, Barakaldo, Basque Country, Spain
    Clin Endocrinol (Oxf) 69:705-12. 2008
    ....
  24. ncbi Contribution of MIC-A polymorphism to type 1 diabetes mellitus in Basques
    J Ramón Bilbao
    Endocrinology and Diabetes Research Group, Hospital de Cruces, Barakaldo, E48903, Basque Country, Spain
    Ann N Y Acad Sci 958:321-4. 2002
    ..Nevertheless, the protective effect of A9 allele seems independent from HLA, since it does not appear to be associated with any particular extended haplotype...