M Blanca

Summary

Country: Spain

Publications

  1. ncbi Decrease of selective immunoglobulin E response to amoxicillin despite repeated administration of benzylpenicillin and penicillin V
    T Fernandez
    Research Laboratory for Allergic Diseases, Carlos Haya Hospital, Malaga, Spain
    Clin Exp Allergy 35:1645-50. 2005
  2. doi Non-immediate reactions to beta-lactams: diagnostic value of skin testing and drug provocation test
    A Padial
    Clinica Norsalud, Madrid, Spain
    Clin Exp Allergy 38:822-8. 2008
  3. ncbi IgE antibodies to penicillin in skin test negative patients
    M J Torres
    Servicio de Alergia, Hospital Universitario La Paz, Paseo de La Castellana 2612, 8046 Madrid, Spain
    Allergy 57:965. 2002
  4. ncbi Side-chain-specific reactions to betalactams: 14 years later
    M Blanca
    Allergy Service, University Hospital La Paz, Paseo de la Castellana no 261, 28046 Madrid, Spain
    Clin Exp Allergy 32:192-7. 2002
  5. doi Diagnosis of immediate hypersensitivity reactions to radiocontrast media
    M Salas
    Allergy Service, Carlos Haya Hospital, Malaga, Spain
    Allergy 68:1203-6. 2013
  6. doi Update on the evaluation of hypersensitivity reactions to betalactams
    M Blanca
    Allergy Service, Carlos Haya Hospital, Malaga, Spain
    Allergy 64:183-93. 2009
  7. doi Calcitonin gene-related peptide modulates interleukin-13 in circulating cutaneous lymphocyte-associated antigen-positive T cells in patients with atopic dermatitis
    C Antunez
    Research Unit for Allergic Diseases, Allergy Service, Carlos Haya Hospital, Malaga, Spain
    Br J Dermatol 161:547-53. 2009
  8. doi Hypersensitivity reactions to fluoroquinolones: analysis of the factors involved
    N Blanca-Lopez
    Allergy Service, Infanta Leonor Hospital, Madrid, Spain
    Clin Exp Allergy 43:560-7. 2013
  9. ncbi The diagnostic interpretation of basophil activation test in immediate allergic reactions to betalactams
    M J Torres
    Research Unit for Allergic Diseases, Allergy Service, Carlos Haya Hospital, Malaga, Spain
    Clin Exp Allergy 34:1768-75. 2004
  10. doi Mediator release after nasal aspirin provocation supports different phenotypes in subjects with hypersensitivity reactions to NSAIDs
    P Campo
    Allergy Service, Carlos Haya Hospital, Malaga, Malaga, Spain
    Allergy 68:1001-7. 2013

Collaborators

Detail Information

Publications62

  1. ncbi Decrease of selective immunoglobulin E response to amoxicillin despite repeated administration of benzylpenicillin and penicillin V
    T Fernandez
    Research Laboratory for Allergic Diseases, Carlos Haya Hospital, Malaga, Spain
    Clin Exp Allergy 35:1645-50. 2005
    ..After the reaction, however, the hapten induces a boosting phenomenon, which may increase the titre and the affinity of the antibody, with the resulting risk of developing allergic reactions to other penicillins...
  2. doi Non-immediate reactions to beta-lactams: diagnostic value of skin testing and drug provocation test
    A Padial
    Clinica Norsalud, Madrid, Spain
    Clin Exp Allergy 38:822-8. 2008
    ..The time between drug intake and the reaction appearance is generally 24-48 h. Because the mechanisms involved are not completely understood, diagnostic tests for these reactions have still to be fully validated...
  3. ncbi IgE antibodies to penicillin in skin test negative patients
    M J Torres
    Servicio de Alergia, Hospital Universitario La Paz, Paseo de La Castellana 2612, 8046 Madrid, Spain
    Allergy 57:965. 2002
  4. ncbi Side-chain-specific reactions to betalactams: 14 years later
    M Blanca
    Allergy Service, University Hospital La Paz, Paseo de la Castellana no 261, 28046 Madrid, Spain
    Clin Exp Allergy 32:192-7. 2002
  5. doi Diagnosis of immediate hypersensitivity reactions to radiocontrast media
    M Salas
    Allergy Service, Carlos Haya Hospital, Malaga, Spain
    Allergy 68:1203-6. 2013
    ..We analyzed the diagnostic value of a skin test (ST), drug provocation test (DPT) and basophil activation test (BAT) in patients with symptoms compatible with IHR to RCM...
  6. doi Update on the evaluation of hypersensitivity reactions to betalactams
    M Blanca
    Allergy Service, Carlos Haya Hospital, Malaga, Spain
    Allergy 64:183-93. 2009
    ..For nonimmediate reactions, skin testing appears to be less sensitive than previous results, although more studies need to be carried out in this direction. Nevertheless, the drug provocation test is still necessary for diagnosis...
  7. doi Calcitonin gene-related peptide modulates interleukin-13 in circulating cutaneous lymphocyte-associated antigen-positive T cells in patients with atopic dermatitis
    C Antunez
    Research Unit for Allergic Diseases, Allergy Service, Carlos Haya Hospital, Malaga, Spain
    Br J Dermatol 161:547-53. 2009
    ..Neuropeptides (NPs) may play an important role in the pathogenesis of atopic dermatitis (AD) by regulating immune responses and contributing to the cross-talk between the immune and nervous systems...
  8. doi Hypersensitivity reactions to fluoroquinolones: analysis of the factors involved
    N Blanca-Lopez
    Allergy Service, Infanta Leonor Hospital, Madrid, Spain
    Clin Exp Allergy 43:560-7. 2013
    ..Hypersensitivity reactions to fluoroquinolones seem to be on the increase, especially immediate type reactions...
  9. ncbi The diagnostic interpretation of basophil activation test in immediate allergic reactions to betalactams
    M J Torres
    Research Unit for Allergic Diseases, Allergy Service, Carlos Haya Hospital, Malaga, Spain
    Clin Exp Allergy 34:1768-75. 2004
    ..Basophil activation by allergens, including drugs, has been used to determine sensitivity and to study IgE recognition and cross-reactivity...
  10. doi Mediator release after nasal aspirin provocation supports different phenotypes in subjects with hypersensitivity reactions to NSAIDs
    P Campo
    Allergy Service, Carlos Haya Hospital, Malaga, Malaga, Spain
    Allergy 68:1001-7. 2013
    ....
  11. ncbi Nonimmediate reactions to systemic corticosteroids suggest an immunological mechanism
    A Padial
    Servicio de Alergologia, Hospital Universitario La Paz, Madrid, Spain
    Allergy 60:665-70. 2005
    ..In order to verify an immunological involvement we evaluated a group of patients with symptoms compatible with nonimmediate allergic reactions to CS...
  12. doi Response to a selective COX-2 inhibitor in patients with urticaria/angioedema induced by nonsteroidal anti-inflammatory drugs
    I Doña
    Allergy Service, Carlos Haya Hospital, Malaga, Spain
    Allergy 66:1428-33. 2011
    ..In subjects with hypersensitivity reactions with cross-intolerance to nonsteroidal anti-inflammatory drugs (NSAIDs), tolerance to selective COX-2 inhibitors has not been evaluated in large series of well-phenotyped cases...
  13. doi Diagnostic evaluation of patients with nonimmediate cutaneous hypersensitivity reactions to iodinated contrast media
    M J Torres
    Allergy Service, Carlos Haya Hospital, Malaga, Spain
    Allergy 67:929-35. 2012
    ..The aim of this study was to establish the role of skin testing and the drug provocation test (DPT) in the diagnosis of nonimmediate reactions to CM...
  14. ncbi T cell assessment in allergic drug reactions during the acute phase according to the time of occurrence
    M J Torres
    Allergy Service, Carlos Haya Hospital, 29009 Malaga, Spain
    Int J Immunopathol Pharmacol 19:119-30. 2006
    ..In delayed reactions there is a parallelism between results found in skin and peripheral blood with a higher participation of CD4+ cells the more severe the reaction...
  15. doi Prevalence and clinical relevance of local allergic rhinitis
    C Rondon
    Allergy Service, Carlos Haya Hospital, Malaga, Spain
    Allergy 67:1282-8. 2012
    ....
  16. doi Value of the clinical history in the diagnosis of urticaria/angioedema induced by NSAIDs with cross-intolerance
    N Blanca-Lopez
    Allergy Service, Infanta Leonor Hospital, Madrid, Spain
    Clin Exp Allergy 43:85-91. 2013
    ..Diagnostic evaluation is based on the clinical history and a drug provocation test...
  17. doi Immunoglobulin E-mediated hypersensitivity to amoxicillin: in vivo and in vitro comparative studies between an injectable therapeutic compound and a new commercial compound
    M J Torres
    Research Unit for Allergic Diseases, Allergy Service, Carlos Haya Hospital, Malaga, Spain
    Clin Exp Allergy 41:1595-601. 2011
    ..Skin testing with amoxicillin (AX) is necessary to diagnose immediate hypersensitivity reactions to this β-lactam. A commercial AX (DIA-AX) has recently become available for skin testing...
  18. ncbi Different lymphocyte markers and cytokine expression in peripheral blood mononuclear cells in children with acute atopic dermatitis
    C Antunez
    Research Unit for Allergic Diseases, Allergy Service, Carlos Haya Hospital, Malaga, Spain
    Allergol Immunopathol (Madr) 32:252-8. 2004
    ..AD is characterized by the presence of clinical symptoms of both IgE antibody-mediated immediate hypersensitivity and specific T lymphocyte-mediated delayed hypersensitivity...
  19. pmc Monitoring non-immediate allergic reactions to iodine contrast media
    M J Torres
    Allergy Service, Carlos Haya Hospital, Malaga, Spain
    Clin Exp Immunol 152:233-8. 2008
    ..Moreover, the positive results in skin tests and lymphocyte proliferation tests indicated that an important cross-reactivity exists...
  20. doi Differential gene expression in drug hypersensitivity reactions: induction of alarmins in severe bullous diseases
    T Bellon
    Research Unit, Hospital La Paz FIBHULP, P masculine Castellana 261, 28046 Madrid, Spain
    Br J Dermatol 162:1014-22. 2010
    ..Although drug-specific T cells seem to be involved, the cellular and molecular bases of their aetiopathology are not fully understood...
  21. doi Immediate hypersensitivity reactions to ibuprofen and other arylpropionic acid derivatives
    N Blanca-Lopez
    Allergy Service, Infanta Leonor University Hospital, Madrid, Spain
    Allergy 71:1048-56. 2016
    ....
  22. doi NSAID-induced urticaria/angioedema does not evolve into chronic urticaria: a 12-year follow-up study
    I Doña
    Allergy Service, Carlos Haya Hospital, Malaga, Spain
    Allergy 69:438-44. 2014
    ..Our aim was to verify whether these entities are related by following up a large cohort of patients with NIUA as well as a control group over a long period of time...
  23. ncbi Diagnosis of immediate allergic reactions to beta-lactam antibiotics
    M J Torres
    Allergy Service, Carlos Haya Hospital, Malaga, Spain
    Allergy 58:961-72. 2003
  24. ncbi Nonimmediate allergic reactions induced by drugs: pathogenesis and diagnostic tests
    M J Torres
    Allergy Service, Carlos Haya Hospital, Malaga, Spain
    J Investig Allergol Clin Immunol 19:80-90. 2009
    ..Further studies are thus required in order to improve our understanding of NIRs and refine our diagnostic criteria...
  25. ncbi Drug hypersensitivity reactions: response patterns, drug involved, and temporal variations in a large series of patients
    I Doña
    Allergy Service, Carlos Haya Hospital, Malaga, Spain
    J Investig Allergol Clin Immunol 22:363-71. 2012
    ..Drug hypersensitivity reactions (DHRs) are among the most frequent reasons for consultation in allergy departments, and are becoming more common due to increasing prevalence and case complexity...
  26. ncbi Continued need of appropriate betalactam-derived skin test reagents for the management of allergy to betalactams
    M Blanca
    Allergy Service, Carlos Haya Hospital, Malaga, Spain
    Clin Exp Allergy 37:166-73. 2007
    ..Furthermore, skin tests are the most readily available form of allergy testing for physicians. This paper reviews the results of skin tests in BL allergy and provides evidence for their continued need...
  27. doi Seasonal Local Allergic Rhinitis in Areas With High Concentrations of Grass Pollen
    N Blanca-Lopez
    Allergy Service, Infanta Leonor Hospital, Madrid, Spain
    J Investig Allergol Clin Immunol 26:83-91. 2016
    ..It unknown whether LAR is limited to areas with low or moderate aeroallergen exposure...
  28. doi Immediate reactions to more than one NSAID must not be considered as cross-hypersensitivity unless asa tolerance is verified
    D Perez-Alzate
    Allergy Service, Infanta Leonor Hospital, Madrid, Spain
    J Investig Allergol Clin Immunol . 2016
    ..The hallmark for this category is that they present a reaction after ASA intake or challenge. Whether patients react to two or more NSAIDs with tolerance to ASA remains to be studied (selective reactions, SRs)...
  29. ncbi Local allergic rhinitis: concept, clinical manifestations, and diagnostic approach
    C Rondon
    Allergy Service, Carlos Haya Hospital, Malaga, Spain
    J Investig Allergol Clin Immunol 20:364-71; quiz 2 p following 371. 2010
    ....
  30. ncbi Skin testing for immediate hypersensitivity to betalactams: comparison between two commercial kits
    J L Rodríguez-Bada
    Research Unit for Allergic Diseases, Allergy Service, Carlos Haya Hospital, Malaga, Spain
    Allergy 61:947-51. 2006
    ..The withdrawal of these products from the market has set us back to the early days, before the introduction of reagents for in vivo testing...
  31. ncbi Different cytokine production and activation marker profiles in circulating cutaneous-lymphocyte-associated antigen T cells from patients with acute or chronic atopic dermatitis
    C Antunez
    Research Unit for Allergic Diseases, Allergy Service, Carlos Haya Hospital, Malaga, Spain
    Clin Exp Allergy 34:559-66. 2004
    ..Atopic dermatitis (AD) is an inflammatory skin disease whose lesions can have two stages: acute and chronic. In skin biopsies a biphasic pattern of cytokine expression has been shown, Th2 in acute lesions and Th1 in chronic AD lesions...
  32. doi Influence of age on IgE response in peanut-allergic children and adolescents from the Mediterranean area
    A Garcia-Blanca
    Allergy Service, Infanta Leonor Hospital, Madrid, Spain
    Pediatr Allergy Immunol 26:497-502. 2015
    ..We studied sensitization to Ara h 2, Ara h 9, and Pru p 3 in a peanut allergic children/adolescents and the relationship with peach and pollen...
  33. ncbi Importance of skin testing with major and minor determinants of benzylpenicillin in the diagnosis of allergy to betalactams. Statement from the European Network for Drug Allergy concerning AllergoPen withdrawal
    M J Torres
    Allergy Service, Carlos Haya Hospital, Malaga, Spain
    Allergy 61:910-1. 2006
  34. ncbi Adverse drug reactions with an immunological basis: from clinical practice to basic research
    E Sanchez
    Allergy Service, University Hospital La Paz, Paseo de la Castellana no 261, E 28046 Madrid, Spain
    Allergy 57:41-4. 2002
  35. doi Characteristics of subjects experiencing hypersensitivity to non-steroidal anti-inflammatory drugs: patterns of response
    I Doña
    Allergy Service, Carlos Haya Hospital Pabellon C, Malaga, Spain
    Clin Exp Allergy 41:86-95. 2011
    ..The contribution of each of these mechanisms to the reactions is not well known...
  36. doi Selective immediate responders to amoxicillin and clavulanic acid tolerate penicillin derivative administration after confirming the diagnosis
    N Blanca-Lopez
    Allergy Service, Hospital Infanta Leonor, Madrid, Spain
    Allergy 70:1013-9. 2015
    ..An increasing number of patients show immediate selective hypersensitivity reactions to clavulanic acid (CLV) and amoxicillin (AX), probably due to their increased prescription. The maintenance of this response should be established...
  37. ncbi Pigeon Fancier's Lung after low exposure
    M Rosal-Sanchez
    Hospital Universitario La Paz, Paseo de la Castellana 261, 28046 Madrid, Spain
    Allergy 57:649. 2002
  38. ncbi Diagnostic evaluation of a large group of patients with immediate allergy to penicillins: the role of skin testing
    M J Torres
    Research Unit for Allergic Diseases, Carlos Haya Hospital, Malaga, Spain
    Allergy 56:850-6. 2001
    ..The incorporation of additional reagents and the development of new tests are required, and these will probably change as the patterns of consumption vary...
  39. ncbi Immediate hypersensitivity to cephalosporins
    Antonino Romano
    Department of Internal Medicine and Geriatrics, UCSC Allergy Unit, Cl Columbus, I 00168 Rome, Italy
    Allergy 57:52-7. 2002
  40. ncbi Monoclonal antibodies to amoxicillin express different idiotypes determined by anti-idiotype antibodies production
    C Mayorga
    Reaearch Unit for Allergic Diseases, Carlos Haya Hospital, E 29009 Málaga, Spain
    Allergy 57:45-51. 2002
    ..We conclude that such a small molecule as amoxicillin can present several antigenic determinants that induce a panel of antibody specificities especially directed against the side chain...
  41. ncbi Clinical evaluation of Pharmacia CAP System RAST FEIA amoxicilloyl and benzylpenicilloyl in patients with penicillin allergy
    M Blanca
    Research Unit for Allergic Diseases, Carlos Haya Hospital, Malaga, Spain
    Allergy 56:862-70. 2001
    ..The combination of in vivo and in vitro tests for estimating IgE antibodies to penicillins is important because of the existence of patients with a positive history but negative skin test...
  42. ncbi [Hypersensitivity reactions to beta-lactam antibiotics in childhood]
    M Blanca
    Servicio de Alergología Hospital Regional Carlos Haya Málaga Spain
    Allergol Immunopathol (Madr) 31:103-9. 2003
  43. ncbi Disagreement and concerns regarding the article recently published by Macy and Burchette in Allergy 2002;57:1151
    M Blanca
    Allergy 59:111-2; author reply 113. 2004
  44. ncbi IgE antibodies to betalactams: relationship between the triggering hapten and the specificity of the immune response
    C Antunez
    Research Laboratory, Carlos Haya Hospital, Malaga, Spain
    Allergy 61:940-6. 2006
    ..After an allergic episode, there is an increase in IgE that decreases over time. We analysed the response of patients allergic to BL after penicillin administration, with emphasis on IgE cross-reactivity...
  45. ncbi Relevance of the determination of serum-specific IgE antibodies in the diagnosis of immediate beta-lactam allergy
    C Fontaine
    Exploration des allergies Maladies Respiratoires and INSERM U454 IFR3, Hopital Arnaud de Villeneuve, University Hospital of Montpellier, Montpellier Cedex 5, France
    Allergy 62:47-52. 2007
    ..They can be explored by in vivo and/or in vitro tests. The measurement of serum-specific immunoglobulin E (IgE) presents several advantages: safety, simplicity, and availability to nonallergologist physicians...
  46. ncbi Diagnosis of nonimmediate reactions to beta-lactam antibiotics
    A Romano
    Oasi Maria SS, Troina, and C I Columbus, Rome, Italy
    Allergy 59:1153-60. 2004
    ....
  47. ncbi Controlled administration of penicillin to patients with a positive history but negative skin and specific serum IgE tests
    M J Torres
    Research Unit for Allergic Diseases, Carlos Haya Hospital, Malaga, Spain
    Clin Exp Allergy 32:270-6. 2002
    ..It is thought that these patients require additional tests to confirm the diagnosis...
  48. ncbi Skin test evaluation in nonimmediate allergic reactions to penicillins
    M J Torres
    Research Unit for Allergic Diseases, Carlos Haya Hospital, Malaga, Spain
    Allergy 59:219-24. 2004
    ..Although patch testing (PT) and intradermal testing (IT) are used for diagnosis, comparative results have never been adequately performed. We compared PT and IT in subjects with NIR to AP...
  49. ncbi In vitro T-cell responses to beta-lactam drugs in immediate and nonimmediate allergic reactions
    I Luque
    Research Unit for Allergic Diseases, Carlos Haya Hospital, , Spain
    Allergy 56:611-8. 2001
    ..Interestingly, positive T-cell proliferative responses can be observed 10 or more years after the occurrence of the reaction without further exposure to the drug...
  50. ncbi Drug provocation testing in the diagnosis of drug hypersensitivity reactions: general considerations
    W Aberer
    Department of Environmental Dermatology, University of Graz, Auenbruggerplatz 8, A 8036 Graz, Austria
    Allergy 58:854-63. 2003
  51. ncbi Characterization of specific IgE response in vitro against protein and drug allergens using atopic and normal donors
    A Akesson
    Department of Immunotechnology, Lund University, Sweden
    Allergy 57:193-200. 2002
    ..Different cell culture systems have been evaluated for their ability to support such IgE secretion...
  52. ncbi General considerations for skin test procedures in the diagnosis of drug hypersensitivity
    K Brockow
    Klinik und Poliklinik fur Dermatologie und Allergologie, Muenchen, Germany
    Allergy 57:45-51. 2002
  53. ncbi Differences in the immunological responses in drug- and virus-induced cutaneous reactions in children
    M J Torres
    Research Laboratory for Allergic Diseases, Carlos Haya Hospital, Malaga, Spain
    Blood Cells Mol Dis 30:124-31. 2003
    ....
  54. pmc Anti-oxidant enzyme activities and expression and oxidative damage in patients with non-immediate reactions to drugs
    J A Cornejo-Garcia
    Research Laboratory for Allergic Diseases, Carlos Haya Hospital, Malaga, Spain
    Clin Exp Immunol 145:287-95. 2006
    ..Our observations indicate that oxidative damage occurs in non-immediate reactions. Carbonyl stress and the inadequacy of the anti-oxidant defences are probable causes...
  55. ncbi Immediate hypersensitivity reactions to penicillins and other betalactams
    C Antunez
    Research Unit for Allergic Diseases, Carlos Haya Hospital, Malaga, Spain
    Curr Pharm Des 12:3327-33. 2006
    ..These are relevant for the appropriate selection of antimicrobial drugs in patients who have immediate hypersensitivity to betalactams...
  56. ncbi Differential cytokine and transcription factor expression in patients with allergic reactions to drugs
    J A Cornejo-Garcia
    Research Laboratory for Allergic Diseases, Carlos Haya Hospital Fundacion IMABIS, Malaga, Spain
    Allergy 62:1429-38. 2007
    ..We studied the extension of this polarization in DR and IR by examining the cytokine and transcription factor profile in T-cell subpopulations during the acute phase of an ADR...
  57. ncbi Drug hypersensitivity: insights into pathomechanisms
    E Martin
    Allergy Service, Research Unit for Allergic Diseases, Carlos Haya Hospital, Malaga Spain
    Eur Ann Allergy Clin Immunol 37:207-12. 2005
    ....
  58. ncbi Diagnostic tests based on human basophils: more potentials and perspectives than pitfalls. II. Technical issues
    A L De Week
    University of Navarra, Pamplona, Spain
    J Investig Allergol Clin Immunol 18:143-55. 2008
    ....
  59. ncbi Rapid release of Ole e 1 from olive pollen using different solvents
    J Carnes
    C B F LETI, S A, Research and Development Department, Tres Cantos, Madrid, Spain
    Allergy 57:798-804. 2002
    ..Solubility is an important characteristic of allergenic molecules. The aim of this study was to investigate the solubility of Ole e 1, a major allergen of Olea europaea, using different solvents...
  60. ncbi Memory to the hapten in non-immediate cutaneous allergic reactions to betalactams resides in a lymphocyte subpopulation expressing both CD45RO and CLA markers
    M Blanca
    Research Unit for Allergic Diseases, Carlos Haya Hospital, Malaga, Spain
    Blood Cells Mol Dis 31:75-9. 2003
    ..These findings may have relevance to understanding the involvement of T cells in allergic reactions to penicillins...
  61. doi Seasonal idiopathic rhinitis with local inflammatory response and specific IgE in absence of systemic response
    C Rondon
    Allergy Service Carlos Haya Hospital, Malaga, Spain
    Allergy 63:1352-8. 2008
    ..We examined nasal mucosa inflammation, the presence of nasal specific-IgE and the response to nasal allergen provocation test (NAPT) in patients with seasonal IR who presented symptoms only in spring...
  62. ncbi Penicillin allergy
    M J Torres
    Clin Exp Allergy 33:714. 2003