Alejandro Balsa

Summary

Country: Spain

Publications

  1. pmc Testing for the association of the KIAA1109/Tenr/IL2/IL21 gene region with rheumatoid arthritis in a European family-based study
    Vitor Hugo Teixeira
    GenHotel EA3886, Evry University Paris 7 University Medical School, AutoCure European Consortium, Evry Genopole, France
    Arthritis Res Ther 11:R45. 2009
  2. ncbi Value of Disease Activity Score 28 (DAS28) and DAS28-3 compared to American College of Rheumatology-defined remission in rheumatoid arthritis
    Alejandro Balsa
    Rheumatology Unit, Hospital Universitario La Paz, Madrid, Spain
    J Rheumatol 31:40-6. 2004
  3. doi [Defining remission in Rheumatoid Arthritis. New ACR/EULAR criteria]
    Alejandro Balsa
    Servicio de Reumatologia, Hospital Universitario La Paz, Reumatologia, Universidad Autonoma de Madrid, Madrid, Espana
    Reumatol Clin 6:S12-5. 2011
  4. pmc Influence of HLA DRB1 alleles in the susceptibility of rheumatoid arthritis and the regulation of antibodies against citrullinated proteins and rheumatoid factor
    Alejandro Balsa
    Servicio de Reumatologia, Hospital Universitario La Paz, Paseo de la Castellana, 261, Madrid, 28046, Spain
    Arthritis Res Ther 12:R62. 2010
  5. doi Superiority of SDAI over DAS-28 in assessment of remission in rheumatoid arthritis patients using power Doppler ultrasonography as a gold standard
    Alejandro Balsa
    Rheumatology Unit, Hospital Universitario La Paz, Paseo de la Castellana 261, 28046 Madrid, Spain
    Rheumatology (Oxford) 49:683-90. 2010
  6. doi Prediction of functional impairment and remission in rheumatoid arthritis patients by biochemical variables and genetic polymorphisms
    Alejandro Balsa
    Hospital Universitario La Paz, Paseo de la Castellana, 261, 28046 Madrid, Spain
    Rheumatology (Oxford) 49:458-66. 2010
  7. ncbi [Antibodies to citrullinated peptides in rheumathoid arthritis]
    Alejandro Balsa
    Servicio de Reumatologia, Hospital Universitario La Paz, Madrid, Espana
    Med Clin (Barc) 128:668-73. 2007
  8. doi A dual action of rheumatoid arthritis synovial fibroblast IL-15 expression on the equilibrium between CD4+CD25+ regulatory T cells and CD4+CD25- responder T cells
    Marta Benito-Miguel
    Department of Rheumatology, Hospital Universitario La Paz, Madrid, Spain
    J Immunol 183:8268-79. 2009
  9. doi Tackling missing radiographic progression data: multiple imputation technique compared with inverse probability weights and complete case analysis
    Miguel A Descalzo
    Research Unit, Sociedad Española de Reumatología, Madrid, Spain
    Rheumatology (Oxford) 52:331-6. 2013
  10. pmc The TT genotype of the STAT4 rs7574865 polymorphism is associated with high disease activity and disability in patients with early arthritis
    Amalia Lamana
    Rheumatology Service, Hospital Universitario de la Princesa, Instituto de Investigación Sanitaria Princesa, Madrid, Spain
    PLoS ONE 7:e43661. 2012

Collaborators

Detail Information

Publications57

  1. pmc Testing for the association of the KIAA1109/Tenr/IL2/IL21 gene region with rheumatoid arthritis in a European family-based study
    Vitor Hugo Teixeira
    GenHotel EA3886, Evry University Paris 7 University Medical School, AutoCure European Consortium, Evry Genopole, France
    Arthritis Res Ther 11:R45. 2009
    ..Therefore, our aim was to test this association in populations of European origin by using a family-based approach...
  2. ncbi Value of Disease Activity Score 28 (DAS28) and DAS28-3 compared to American College of Rheumatology-defined remission in rheumatoid arthritis
    Alejandro Balsa
    Rheumatology Unit, Hospital Universitario La Paz, Madrid, Spain
    J Rheumatol 31:40-6. 2004
    ....
  3. doi [Defining remission in Rheumatoid Arthritis. New ACR/EULAR criteria]
    Alejandro Balsa
    Servicio de Reumatologia, Hospital Universitario La Paz, Reumatologia, Universidad Autonoma de Madrid, Madrid, Espana
    Reumatol Clin 6:S12-5. 2011
    ..Recently, a subcommittee of the ACR and EULAR has proposed new criteria for remission based on a categorical classification and a composite score like SDAI allowing their use in clinical practice...
  4. pmc Influence of HLA DRB1 alleles in the susceptibility of rheumatoid arthritis and the regulation of antibodies against citrullinated proteins and rheumatoid factor
    Alejandro Balsa
    Servicio de Reumatologia, Hospital Universitario La Paz, Paseo de la Castellana, 261, Madrid, 28046, Spain
    Arthritis Res Ther 12:R62. 2010
    ..The purpose of this study was to investigate the association between HLA-DRB1 alleles with susceptibility to rheumatoid arthritis (RA) and production of antibodies against citrullinated proteins (ACPA) and rheumatoid factor (RF)...
  5. doi Superiority of SDAI over DAS-28 in assessment of remission in rheumatoid arthritis patients using power Doppler ultrasonography as a gold standard
    Alejandro Balsa
    Rheumatology Unit, Hospital Universitario La Paz, Paseo de la Castellana 261, 28046 Madrid, Spain
    Rheumatology (Oxford) 49:683-90. 2010
    ..To investigate the accuracy of composite scores in classifying RA patients who are in remission using the absence of inflammatory activity detected by ultrasound (US) as a gold standard...
  6. doi Prediction of functional impairment and remission in rheumatoid arthritis patients by biochemical variables and genetic polymorphisms
    Alejandro Balsa
    Hospital Universitario La Paz, Paseo de la Castellana, 261, 28046 Madrid, Spain
    Rheumatology (Oxford) 49:458-66. 2010
    ..To develop a model to predict RA outcome based on biochemical variables and single nucleotide polymorphisms (SNPs)...
  7. ncbi [Antibodies to citrullinated peptides in rheumathoid arthritis]
    Alejandro Balsa
    Servicio de Reumatologia, Hospital Universitario La Paz, Madrid, Espana
    Med Clin (Barc) 128:668-73. 2007
    ..A model is proposed of how these antibodies are produced and lead to chronic synovial inflammation...
  8. doi A dual action of rheumatoid arthritis synovial fibroblast IL-15 expression on the equilibrium between CD4+CD25+ regulatory T cells and CD4+CD25- responder T cells
    Marta Benito-Miguel
    Department of Rheumatology, Hospital Universitario La Paz, Madrid, Spain
    J Immunol 183:8268-79. 2009
    ....
  9. doi Tackling missing radiographic progression data: multiple imputation technique compared with inverse probability weights and complete case analysis
    Miguel A Descalzo
    Research Unit, Sociedad Española de Reumatología, Madrid, Spain
    Rheumatology (Oxford) 52:331-6. 2013
    ....
  10. pmc The TT genotype of the STAT4 rs7574865 polymorphism is associated with high disease activity and disability in patients with early arthritis
    Amalia Lamana
    Rheumatology Service, Hospital Universitario de la Princesa, Instituto de Investigación Sanitaria Princesa, Madrid, Spain
    PLoS ONE 7:e43661. 2012
    ..In the present study, we investigated the effects of these genetic variants on disease activity and disability in patients with early arthritis...
  11. pmc Frequency of Th17 CD4+ T cells in early rheumatoid arthritis: a marker of anti-CCP seropositivity
    Irene Arroyo-Villa
    Department of Rheumatology, Hospital Universitario La Paz IdiPAZ, Madrid, Spain
    PLoS ONE 7:e42189. 2012
    ..To examine the frequency and phenotype of Th17 cells in the peripheral blood of early RA (eRA) patients...
  12. doi Practice guidelines for the use of subcutaneous abatacept
    Emilio Martin Mola
    Servicio de Reumatologia, Hospital Universitario La Paz, IdiPAZ, Madrid, España Electronic address
    Reumatol Clin 10:218-26. 2014
    ..To review the clinical evidence on subcutaneous (sc) abatacept and to formulate recommendations in order to clear up points related to its use in rheumatology...
  13. ncbi Peripheral blood T lymphocytes from patients with early rheumatoid arthritis express RANKL and interleukin-15 on the cell surface and promote osteoclastogenesis in autologous monocytes
    María Eugenia Miranda-Carús
    Department of Rheumatology, Hospital Universitario La Paz, Madrid, Spain
    Arthritis Rheum 54:1151-64. 2006
    ..To investigate the osteoclastogenic potential of T cells from the peripheral blood (PB) and synovial fluid (SF) of patients with rheumatoid arthritis (RA) on autologous monocytes, and to study the cytokines implicated in this process...
  14. pmc IL-15 expression on RA synovial fibroblasts promotes B cell survival
    Marta Benito-Miguel
    Department of Rheumatology, Hospital Universitario La Paz, Madrid, Spain
    PLoS ONE 7:e40620. 2012
    ..The purpose of this study was to examine the role of RA Synovial Fibroblast (RASFib) IL-15 expression on B cell survival...
  15. ncbi Increased risk of tuberculosis in patients with rheumatoid arthritis
    Loreto Carmona
    Hospital Clinico San Carlos, Madrid, Spain
    J Rheumatol 30:1436-9. 2003
    ..To quantify the risk of tuberculosis (TB) in an unselected sample of patients with rheumatoid arthritis (RA) compared to the risk in the general population...
  16. ncbi Macrophage migration inhibitory factor gene: influence on rheumatoid arthritis susceptibility
    Alfonso Martinez
    Department of Clinical Immunology, Hospital Clinico San Carlos, Madrid, Spain
    Hum Immunol 68:744-7. 2007
    ..6; OR = 1.09; 95% CI = 0.77-1.55). In conclusion, the -173C allele in the MIF promoter region is associated with increased RA predisposition, mainly in early-onset patients...
  17. ncbi Patterns of disease modifying antirheumatic drug use in a Spanish cohort of patients with rheumatoid arthritis
    Isidoro Gonzalez-Alvaro
    Department of Rheumatology, Hospital Universitario de la Princesa, Madrid, Spain
    J Rheumatol 30:697-704. 2003
    ..To determine the adequacy of disease modifying antirheumatic drug (DMARD) prescription to disease activity in patients with rheumatoid arthritis (RA) and to assess whether the reasons for DMARD discontinuation agree with published evidence...
  18. doi Calprotectin in rheumatoid arthritis : association with disease activity in a cross-sectional and a longitudinal cohort
    Miriam García-Arias
    Rheumatology Unit, La Paz University Hospital, Paseo de la Castellana, 261, 28046, Madrid, Spain
    Mol Diagn Ther 17:49-56. 2013
    ....
  19. ncbi Role of SLC22A4, SLC22A5, and RUNX1 genes in rheumatoid arthritis
    Alfonso Martinez
    Department of Clinical Immunology, Hospital Clinico San Carlos, Madrid, Spain
    J Rheumatol 33:842-6. 2006
    ..We studied additional polymorphisms to ascertain whether any SLC22A4/SLC22A5 haplotype is relevant for RA predisposition in a Spanish population...
  20. pmc A functional variant of TLR10 modifies the activity of NFkB and may help predict a worse prognosis in patients with rheumatoid arthritis
    Silvia Torices
    Servicio de Reumatologia, Hospital Universitario Marques de Valdecilla Instituto de Investigación Valdecilla IDIVAL, Avenida Valdecilla s n, 39008, Santander, Spain
    Arthritis Res Ther 18:221. 2016
    ..We aimed at identifying TLR10 variants within all coding regions of the gene in patients with RA as well as studying their functional and clinical significance...
  21. ncbi Rheumatoid arthritis synovial fluid fibroblasts express TRAIL-R2 (DR5) that is functionally active
    María Eugenia Miranda-Carús
    Hospital La Paz, Universidad Autonoma de Madrid, Madrid, Spain
    Arthritis Rheum 50:2786-93. 2004
    ..To examine fibroblasts grown from the synovial fluid of rheumatoid arthritis (RA) patients for TRAIL-R2 expression, and for susceptibility to apoptosis induced by an agonistic anti-TRAIL-R2 monoclonal antibody (mAb)...
  22. doi Effectiveness of a clinical practice intervention in early rheumatoid arthritis
    Miguel Angel Descalzo
    Sociedad Española de Reumatología, Madrid, Spain
    Arthritis Care Res (Hoboken) 64:321-30. 2012
    ..To compare the outcome of early rheumatoid arthritis (RA) patients in a country where early clinics were established versus the outcome of patients in nonprotocolized clinics...
  23. doi Quality standards in a rheumatology Day-Care Hospital Unit. The proposal of the Spanish Society of Rheumatology Day Hospitals' Working Group
    Rosario García-Vicuña
    Servicio de Reumatologia, Hospital Universitario La Princesa, IISP, Madrid, España Electronic address
    Reumatol Clin 10:380-8. 2014
    ..However, the quality standards are poorly documented and mainly limited to structure items rather than including broad and specific areas of this specialty...
  24. ncbi Comparing a tapering strategy to the standard dosing regimen of TNF inhibitors in rheumatoid arthritis patients with low disease activity
    Chamaida Plasencia
    Department of Rheumatology, La Paz University Hospital IdiPAZ, Madrid, Spain
    Clin Exp Rheumatol 34:655-62. 2016
    ..The aim of this study is to compare clinical outcomes, incidence of flares and administered drug reduction between rheumatoid arthritis (RA) patients under TNF inhibitors (TNFi) tapering strategy and RA patients on standard regimen...
  25. doi Anti-citrullinated peptide antibodies and their value for predicting responses to biologic agents: a review
    Emilio Martín-Mola
    Reumatology Department, Hospital Universitario La Paz, Hospital La Paz Institute for Health Research IdiPAZ, Madrid, Spain
    Rheumatol Int 36:1043-63. 2016
    ..Evidence regarding TNFi and tocilizumab is lacking. However, there is a lack of studies with appropriate designs to demonstrate that some drugs are superior to others for ACPA(+) patients. ..
  26. pmc PTGER4 gene variant rs76523431 is a candidate risk factor for radiological joint damage in rheumatoid arthritis patients: a genetic study of six cohorts
    Luis Rodríguez-Rodríguez
    Rheumatology Department and Heath Research Institute IdISSC, Hospital Clinico San Carlos, c o Prof Martín Lagos s n, 28040, Madrid, Spain
    Arthritis Res Ther 17:306. 2015
    ..Prostaglandin E receptor 4 (PTGER4) is implicated in immune regulation and bone metabolism. The aim of this study was to analyze its role in radiological joint damage in rheumatoid arthritis (RA)...
  27. ncbi Human T cells constitutively express IL-15 that promotes ex vivo T cell homeostatic proliferation through autocrine/juxtacrine loops
    María Eugenia Miranda-Carús
    Department of Rheumatology, Hospital Universitario La Paz, Madrid, Spain
    J Immunol 175:3656-62. 2005
    ..In this study, we demonstrate that human T cells constitutively express IL-15 that acts through autocrine/juxtacrine loops to promote ex vivo homeostatic T cell proliferation...
  28. ncbi Association of the major histocompatibility complex with response to infliximab therapy in rheumatoid arthritis patients
    Alfonso Martinez
    Hospital Clinico San Carlos, Madrid, Spain
    Arthritis Rheum 50:1077-82. 2004
    ..To determine whether major histocompatibility complex (MHC) polymorphisms are associated with a good or poor response to infliximab therapy in patients with rheumatoid arthritis (RA)...
  29. doi Influence of immunogenicity on the efficacy of long-term treatment with infliximab in rheumatoid arthritis
    Dora Pascual-Salcedo
    Immunology Unit, Hospital La Paz, Paseo de la Castellana 261, 28046 Madrid, Spain
    Rheumatology (Oxford) 50:1445-52. 2011
    ..To analyse the clinical relevance of the production of anti-infliximab antibodies (anti-infliximab Abs) in patients with RA undergoing infliximab treatment over a prolonged period of time...
  30. doi The PTPN22 R263Q polymorphism is a risk factor for rheumatoid arthritis in Caucasian case-control samples
    Luis Rodríguez-Rodríguez
    Instituto de Parasitologia y Biomedicina Lopez Neyra, CSIC, Armilla and Hospital Clínico San Carlos, Madrid, Spain
    Arthritis Rheum 63:365-72. 2011
    ..Recently, a functional PTPN22 variant (R263Q; rs33996649) was found to be associated with systemic lupus erythematosus (SLE). This study was undertaken to analyze the influence of this polymorphism on the risk of rheumatoid arthritis (RA)...
  31. doi Infectious complications of biologic agents
    Emilio Martín-Mola
    Department of Rheumatology, Hospital Universitario La Paz, Paseo de la Castellana 261, Madrid 28046, Spain
    Rheum Dis Clin North Am 35:183-99. 2009
    ..Reported risks for developing infection differ among studies. This article provides an overview of which studies the authors consider the most relevant...
  32. ncbi Rheumatoid arthritis: genetic variants as biomarkers of cardiovascular disease
    Luis Rodríguez-Rodríguez
    Rheumatology Department, Hospital Clinico San Carlos, IdISSC, C Profesor Martin Lagos s n, 28040, Madrid, Spain
    Curr Pharm Des 21:182-201. 2015
    ....
  33. doi Consensus statement on a framework for the management of comorbidity and extra-articular manifestations in rheumatoid arthritis
    Estibaliz Loza
    Madrilenian Society of Rheumatology, Madrid, Spain
    Rheumatol Int 35:445-58. 2015
    ..These recommendations are intended to guide rheumatologists, patients, and other stakeholders, on the early diagnosis and management of comorbidity in RA, in order to improve disease outcomes. ..
  34. doi Abatacept use in rheumatoid arthritis: evidence review and recommendations
    Emilio Martin Mola
    Servicio de Reumatologia, Hospital Universitario La Paz, IdiPAZ, Madrid, Espana
    Reumatol Clin 9:5-17. 2013
    ..To review the clinical evidence on abatacept and to formulate recommendations in order to clear up points related to its use in rheumatology...
  35. doi [Consensus on the Use of Rituximab in Rheumatoid Arthritis. A document with evidence-based recommendations. Grupo de Expertos en Rituximab. ]
    Emilio Martin Mola
    Servicio de Reumatologia, Hospital Universitario La Paz, Madrid, Espana
    Reumatol Clin 7:30-44. 2011
    ..Rituximab has been employed successfully for the treatment of Rheumatoid Arthritis (RA). However, its particular mechanism of action, as well as a lack of concrete guidelines for its management have generated doubts on its use...
  36. ncbi [What are patients with early rheumatoid arthritis like in Spain? Description of the PROAR cohort]
    Virginia Villaverde García
    Unidad de Reumatologia, Hospital de Mostoles, Mostoles, Madrid, Espana
    Reumatol Clin 5:115-20. 2009
    ..To identify factors present in recent onset arthritis that may help to predict rheumatoid arthritis (RA), and to describe a cohort of recent onset RA...
  37. ncbi IL-15 and the initiation of cell contact-dependent synovial fibroblast-T lymphocyte cross-talk in rheumatoid arthritis: effect of methotrexate
    María Eugenia Miranda-Carús
    Department of Rheumatology, Hospital Universitario La Paz, Paseo de la Castellana, Madrid, Spain
    J Immunol 173:1463-76. 2004
    ..In turn, these cytokines stimulate the expression of IL-15, IL-8, and IL-6 in RASFibs, thereby creating a feedback loop that favors persistent synovial inflammation. Methotrexate seems to disrupt this loop by decreasing cell adhesion...
  38. doi A Truncated Variant of ASCC1, a Novel Inhibitor of NF-κB, Is Associated with Disease Severity in Patients with Rheumatoid Arthritis
    Silvia Torices
    Servicio de Reumatologia, Hospital Universitario Marques de Valdecilla Instituto de Investigación Valdecilla, 39011 Santander, Spain Unidad de Genética, Hospital Universitario Marques de Valdecilla Instituto de Investigación Valdecilla, 39011 Santander, Spain
    J Immunol 195:5415-20. 2015
    ....
  39. doi [Consensus statement of the Spanish Society of Rheumatology on risk management of biologic therapy in rheumatic patients]
    Juan Gomez Reino
    Servicio de Reumatologia, Hospital Clinico Universitario, Santiago de Compostela, A Coruna, Espana
    Reumatol Clin 7:284-98. 2011
    ..These recommendations should be a reference to rheumatologists and those involved in the treatment of patients who are using, or about to use biologic therapy irrespectively of the rheumatic disease...
  40. doi Patterns of use and dosing of tocilizumab in the treatment of patients with rheumatoid arthritis in routine clinical practice: the ACT-LIFE study
    Alejandro Balsa
    Department of Rheumatology, IdiPAZ, Hospital Universitario La Paz, Paseo de la Castellana 261, 28046, Madrid, Spain
    Rheumatol Int 35:1525-34. 2015
    ..Tocilizumab seems to be more effective for biologics-naive patients than for biologics-experienced patients, while it proves to be similarly effective when used in combination or monotherapy...
  41. ncbi [The therapeutic blockade of TNF reduces serum levels of interleukin 15 in patients with rheumatoid arthritis]
    Isidoro Gonzalez-Alvaro
    Servicio de Reumatologia, Hospital Universitario de la Princesa, Madrid, Espana
    Reumatol Clin 5:23-7. 2009
    ..To analyze the effect of the TNF blocking agents (aTNF) on the serum levels of interleukin 15 (IL-15). To determine whether baseline IL15 serum levels or their response to aTNF therapy can predict the clinical response to this treatment...
  42. doi Septic arthritis
    Miriam García-Arias
    Rheumatology Unit, La Paz University Hospital, Paseo de la Castellana 261, 28046 Madrid, Spain
    Best Pract Res Clin Rheumatol 25:407-21. 2011
    ..In addition, this article discusses, in particular, prosthetic joint infection and gonococcal arthritis...
  43. ncbi Osteopontin gene polymorphisms in Spanish patients with rheumatoid arthritis
    Elena Urcelay
    Immunology Department, Hospital Universitario San Carlos, Atencion Especializada Area 7, Martin Lagos s n, 28040 Madrid, Spain
    J Rheumatol 32:405-9. 2005
    ..The osteopontin (OPN) gene, with pleiotropic functions in inflammatory and immune responses, has been implicated in the pathogenesis of RA. We studied the association of polymorphisms in the OPN gene and predisposition to RA...
  44. ncbi Association of a functional single-nucleotide polymorphism of PTPN22, encoding lymphoid protein phosphatase, with rheumatoid arthritis and systemic lupus erythematosus
    Gisela Orozco
    Instituto de Parasitologia y Biomedicina, CSIC, Parque Tecnológico de Ciencias de la Salud, Avenida del Conocimiento s n 18100 Armilla, Granada, Spain
    Arthritis Rheum 52:219-24. 2005
    ..To assess the possible association between the PTPN22 gene 1858C-->T polymorphism and the predisposition and clinical expression of 2 systemic autoimmune diseases, rheumatoid arthritis (RA) and systemic lupus erythematosus (SLE)...
  45. pmc Linkage proof for PTPN22, a rheumatoid arthritis susceptibility gene and a human autoimmunity gene
    Laetitia Michou
    GenHotel EA 3886, University Evry Paris 7 Medical School, Member of the AutoCure European Consortium, CP5727, 91057 Evry Genopole Cedex, France
    Proc Natl Acad Sci U S A 104:1649-54. 2007
    ..PTPN22 accounting for approximately 1% of the RA familial aggregation, many new genes could be expected that are as many leads to definitive therapy for autoimmune diseases...
  46. ncbi Interleukin 12 (IL12B) and interleukin 12 receptor (IL12RB1) gene polymorphisms in rheumatoid arthritis
    Gisela Orozco
    Instituto de Parasitologia y Biomedicina, Granada
    Hum Immunol 66:710-5. 2005
    ..These results suggest that IL12B and IL12RB1 genes may not play a relevant role in the susceptibility or severity of RA in the Spanish population...
  47. ncbi Analysis of vascular endothelial growth factor (VEGF) functional variants in rheumatoid arthritis
    Blanca Rueda
    Instituto de Parasitologia y Biomedicina, Granada, Spain
    Hum Immunol 66:864-8. 2005
    ..Our results suggest that the analyzed VEGF promoter polymorphisms may not play a relevant role in RA pathogenesis in our population...
  48. ncbi Analysis of a functional BTNL2 polymorphism in type 1 diabetes, rheumatoid arthritis, and systemic lupus erythematosus
    Gisela Orozco
    Instituto de Biomedicina, CSIC, Granada, Spain
    Hum Immunol 66:1235-41. 2005
    ..The BTNL2 rs2076530 polymorphism is associated with T1D, RA, and SLE because of its strong linkage disequalibrium with predisposing HLA DQB1-DRB1 haplotypes in Caucasian populations...
  49. doi Genome-wide association study of rheumatoid arthritis in the Spanish population: KLF12 as a risk locus for rheumatoid arthritis susceptibility
    Antonio Julia
    Institut de Recerca, Hospital Universitari Vall d Hebron, corrected Barcelona, Spain
    Arthritis Rheum 58:2275-86. 2008
    ..To identify new genes associated with susceptibility to rheumatoid arthritis (RA), using a 2-stage genome-wide association study...
  50. doi Association of STAT4 with rheumatoid arthritis: a replication study in three European populations
    Gisela Orozco
    Instituto de Parasitologia y Biomedicina Lopez Neyra, CSIC, Granada, Spain
    Arthritis Rheum 58:1974-80. 2008
    ....
  51. ncbi HO-1 promoter polymorphism associated with rheumatoid arthritis
    Blanca Rueda
    CSIC, Parque Tecnológico de Ciencias de la Salud, Avenida del Conocimiento s n, Armilla, Granada, Spain
    Arthritis Rheum 56:3953-8. 2007
    ..To investigate the role of the HO-1 gene as a novel functional candidate gene for rheumatoid arthritis (RA)...
  52. ncbi Deficiency of the NF-kappaB inhibitor caspase activating and recruitment domain 8 in patients with rheumatoid arthritis is associated with disease severity
    Ana Fontalba
    Unidad de Genetica Molecular, Hospital Universitario Marques de Valdecilla, Santander, Spain
    J Immunol 179:4867-73. 2007
    ..03) than the CARD8-L allele carriers. Overall, our findings provide molecular insight into the expression of CARD8 by NF-kappaB, and suggest that a deleterious polymorphism of CARD8 may help predict the severity of RA...
  53. ncbi SLC22A4, RUNX1, and SUMO4 polymorphisms are not associated with rheumatoid arthritis: a case-control study in a Spanish population
    Gisela Orozco
    Instituto de Parasitologia y Biomedicina, Granada, Spain
    J Rheumatol 33:1235-9. 2006
    ....
  54. pmc Baseline serum RANKL levels may serve to predict remission in rheumatoid arthritis patients treated with TNF antagonists
    Isidoro Gonzalez-Alvaro
    Rheumatology Service, Hospital Universitario de la Princesa, C Diego de Leon 62, 28006 Madrid, Spain
    Ann Rheum Dis 66:1675-8. 2007
    ..The objective of this study was to investigate whether baseline receptor activator for nuclear factor kappaB ligand (RANKL) and osteoprotegerin (OPG) serum (s) levels can predict the therapeutic response to TNF antagonists (a-TNF)...
  55. ncbi Molecular screening and association study of IL15 gene polymorphisms in rheumatoid arthritis
    Blanca Rueda
    Instituto de Parasitologia y Biomedicina Lopez Neyra, CSIC, Granada, Spain
    Cytokine 38:84-9. 2007
    ..Our results suggest that the IL15 gene polymorphisms do not appear to play a major role in RA genetic predisposition in our population...
  56. pmc The ITGAV rs3738919-C allele is associated with rheumatoid arthritis in the European Caucasian population: a family-based study
    Laurent Jacq
    GenHotel EA3886, Evry Paris VII Universities, 91057 Evry Genopole Cedex, France
    Arthritis Res Ther 9:R63. 2007
    ..002, odds ratio = 1.94, 95% confidence interval = 1.3-2.9). The rs3738919-C allele of the ITGAV gene is associated with RA in the European Caucasian population, suggesting ITGAV as a new minor RA susceptibility gene...
  57. ncbi Analysis of IRF5 gene functional polymorphisms in rheumatoid arthritis
    Blanca Rueda
    Instituto de Biomedicina López Neyra, Granada, Spain
    Arthritis Rheum 54:3815-9. 2006
    ..The aim of this study was to analyze the possible contribution of the IRF5 gene to the predisposition to rheumatoid arthritis (RA)...