Carolyn Williamson

Summary

Affiliation: University of Cape Town
Country: South Africa

Publications

  1. pmc Identification of broadly neutralizing antibody epitopes in the HIV-1 envelope glycoprotein using evolutionary models
    Miguel Lacerda
    School of Mathematics, Statistics and Applied Mathematics, National University of Ireland Galway, Galway, Ireland
    Virol J 10:347. 2013
  2. pmc Transmission of HIV-1 CTL escape variants provides HLA-mismatched recipients with a survival advantage
    Denis R Chopera
    Institute of Infectious Diseases and Molecular Medicine, Division of Medical Virology, Faculty of Health Sciences, University of Cape Town, Cape Town, South Africa
    PLoS Pathog 4:e1000033. 2008
  3. ncbi request reprint A multigene HIV type 1 subtype C modified vaccinia Ankara (MVA) vaccine efficiently boosts immune responses to a DNA vaccine in mice
    Enid Shephard
    Institute of Infectious Disease and Molecular Medicine and Division of Medical Virology, Department of Clinical Laboratory Sciences, University of Cape Town, Cape Town, South Africa
    AIDS Res Hum Retroviruses 24:207-17. 2008
  4. ncbi request reprint A prime-boost immunisation regimen using recombinant BCG and Pr55(gag) virus-like particle vaccines based on HIV type 1 subtype C successfully elicits Gag-specific responses in baboons
    Gerald K Chege
    Institute of Infectious Disease and Molecular Medicine, Faculty of Health Sciences, University of Cape Town, Anzio Road, Observatory, Cape Town, South Africa
    Vaccine 27:4857-66. 2009
  5. pmc Genital tract inflammation during early HIV-1 infection predicts higher plasma viral load set point in women
    Lindi Roberts
    Institute of Infectious Diseases and Molecular Medicine, University of Cape Town Medical School, Observatory, 7925 Cape Town, South Africa
    J Infect Dis 205:194-203. 2012
  6. ncbi request reprint HIV-1 subtype C Pr55gag virus-like particle vaccine efficiently boosts baboons primed with a matched DNA vaccine
    Gerald K Chege
    Medical Virology, Department of Clinical Laboratory Sciences, Faculty of Health Sciences, University of Cape Town, Rondebosch, Cape Town, South Africa
    J Gen Virol 89:2214-27. 2008
  7. ncbi request reprint Broad, high-magnitude and multifunctional CD4+ and CD8+ T-cell responses elicited by a DNA and modified vaccinia Ankara vaccine containing human immunodeficiency virus type 1 subtype C genes in baboons
    Wendy A Burgers
    Institute of Infectious Disease and Molecular Medicine, Faculty of Health Sciences, University of Cape Town, South Africa
    J Gen Virol 90:468-80. 2009
  8. ncbi request reprint Construction, characterization, and immunogenicity of a multigene modified vaccinia Ankara (MVA) vaccine based on HIV type 1 subtype C
    Wendy A Burgers
    Institute of Infectious Disease and Molecular Medicine and Division of Medical Virology, Department of Clinical Laboratory Sciences, University of Cape Town, Cape Town, South Africa
    AIDS Res Hum Retroviruses 24:195-206. 2008
  9. ncbi request reprint Human immunodeficiency virus type 1 subtype C Gag virus-like particle boost substantially improves the immune response to a subtype C gag DNA vaccine in mice
    Ann Jaffray
    Department of Molecular and Cell Biology, Faculty of Science, University of Cape Town, Rondebosch 7701, South Africa
    J Gen Virol 85:409-13. 2004
  10. pmc Increased memory differentiation is associated with decreased polyfunctionality for HIV but not for cytomegalovirus-specific CD8+ T cells
    Catherine Riou
    Division of Immunology, Institute of Infectious Diseases and Molecular Medicine, Faculty of Health Sciences, University of Cape Town, Cape Town, 7925, South Africa
    J Immunol 189:3838-47. 2012

Collaborators

Detail Information

Publications34

  1. pmc Identification of broadly neutralizing antibody epitopes in the HIV-1 envelope glycoprotein using evolutionary models
    Miguel Lacerda
    School of Mathematics, Statistics and Applied Mathematics, National University of Ireland Galway, Galway, Ireland
    Virol J 10:347. 2013
    ..Identification of the epitopes targeted by antibodies that can neutralize diverse HIV-1 strains can provide important clues for the design of a preventative vaccine...
  2. pmc Transmission of HIV-1 CTL escape variants provides HLA-mismatched recipients with a survival advantage
    Denis R Chopera
    Institute of Infectious Diseases and Molecular Medicine, Division of Medical Virology, Faculty of Health Sciences, University of Cape Town, Cape Town, South Africa
    PLoS Pathog 4:e1000033. 2008
    ....
  3. ncbi request reprint A multigene HIV type 1 subtype C modified vaccinia Ankara (MVA) vaccine efficiently boosts immune responses to a DNA vaccine in mice
    Enid Shephard
    Institute of Infectious Disease and Molecular Medicine and Division of Medical Virology, Department of Clinical Laboratory Sciences, University of Cape Town, Cape Town, South Africa
    AIDS Res Hum Retroviruses 24:207-17. 2008
    ..The demonstration that these vaccines induce potent cellular immune responses merits their testing in clinical trials...
  4. ncbi request reprint A prime-boost immunisation regimen using recombinant BCG and Pr55(gag) virus-like particle vaccines based on HIV type 1 subtype C successfully elicits Gag-specific responses in baboons
    Gerald K Chege
    Institute of Infectious Disease and Molecular Medicine, Faculty of Health Sciences, University of Cape Town, Anzio Road, Observatory, Cape Town, South Africa
    Vaccine 27:4857-66. 2009
    ..In addition, a Gag-specific humoral response was elicited. These data support the development of HIV-1 vaccines based on rBCG and Pr55(gag) VLPs...
  5. pmc Genital tract inflammation during early HIV-1 infection predicts higher plasma viral load set point in women
    Lindi Roberts
    Institute of Infectious Diseases and Molecular Medicine, University of Cape Town Medical School, Observatory, 7925 Cape Town, South Africa
    J Infect Dis 205:194-203. 2012
    ..The purpose of this study was to assess if genital inflammation during early HIV-1 infection predisposes women to rapid disease progression...
  6. ncbi request reprint HIV-1 subtype C Pr55gag virus-like particle vaccine efficiently boosts baboons primed with a matched DNA vaccine
    Gerald K Chege
    Medical Virology, Department of Clinical Laboratory Sciences, Faculty of Health Sciences, University of Cape Town, Rondebosch, Cape Town, South Africa
    J Gen Virol 89:2214-27. 2008
    ....
  7. ncbi request reprint Broad, high-magnitude and multifunctional CD4+ and CD8+ T-cell responses elicited by a DNA and modified vaccinia Ankara vaccine containing human immunodeficiency virus type 1 subtype C genes in baboons
    Wendy A Burgers
    Institute of Infectious Disease and Molecular Medicine, Faculty of Health Sciences, University of Cape Town, South Africa
    J Gen Virol 90:468-80. 2009
    ..These candidate vaccines, which are immunogenic in this pre-clinical model, represent an alternative to adenoviral-based vaccines and have been approved for clinical trials...
  8. ncbi request reprint Construction, characterization, and immunogenicity of a multigene modified vaccinia Ankara (MVA) vaccine based on HIV type 1 subtype C
    Wendy A Burgers
    Institute of Infectious Disease and Molecular Medicine and Division of Medical Virology, Department of Clinical Laboratory Sciences, University of Cape Town, Cape Town, South Africa
    AIDS Res Hum Retroviruses 24:195-206. 2008
    ..An accompanying paper describes the immunogenicity of SAAVI MVA-C when given in combination with SAAVI DNA-C...
  9. ncbi request reprint Human immunodeficiency virus type 1 subtype C Gag virus-like particle boost substantially improves the immune response to a subtype C gag DNA vaccine in mice
    Ann Jaffray
    Department of Molecular and Cell Biology, Faculty of Science, University of Cape Town, Rondebosch 7701, South Africa
    J Gen Virol 85:409-13. 2004
    ..This study shows that a low dose of HIV-1 subtype C Gag VLPs can significantly boost the immune response to a single subtype C gag DNA inoculation in mice. These results suggest a possible vaccination regimen for humans...
  10. pmc Increased memory differentiation is associated with decreased polyfunctionality for HIV but not for cytomegalovirus-specific CD8+ T cells
    Catherine Riou
    Division of Immunology, Institute of Infectious Diseases and Molecular Medicine, Faculty of Health Sciences, University of Cape Town, Cape Town, 7925, South Africa
    J Immunol 189:3838-47. 2012
    ..Overall, these data show that the polyfunctional abilities of HIV-specific CD8(+) T cells are influenced by the stage of memory differentiation, which is not the case for CMV-specific responses...
  11. ncbi request reprint Genetic characteristics of HIV-1 subtype C envelopes inducing cross-neutralizing antibodies
    Cecilia Rademeyer
    Institute of Infectious Diseases and Molecular Medicine, Division of Medical Virology, University of Cape Town, Observatory 7925, Cape Town, South Africa
    Virology 368:172-81. 2007
    ..Collectively these data provide some insights into design features of an envelope immunogen aimed at inducing neutralizing antibodies...
  12. pmc Rapid, complex adaptation of transmitted HIV-1 full-length genomes in subtype C-infected individuals with differing disease progression
    Melissa Rose Abrahams
    Division of Medical Virology, Institute of Infectious Disease and Molecular Medicine, University of Cape Town, Cape Town, South Africa
    AIDS 27:507-18. 2013
    ..The purpose of this study was to characterize the earliest changes across the genome of subtype C viruses following transmission, to better understand early control of viremia...
  13. ncbi request reprint Epidemiology of HIV-1 subtypes among men who have sex with men in Cape Town, South Africa
    Keren Middelkoop
    Desmond Tutu HIV Centre, Institute of Infectious Disease and Molecular Medicine and Department of Medicine, University of Cape Town, Cape Town, South Africa Division of Medical Virology and Institute of Infectious Disease and Molecular Medicine, University of Cape Town, Cape Town, South Africa Division of Epidemiology and Biostatistics, School of Public Health and Family Medicine, University of Cape Town, Cape Town, South Africa Center for Learning and Innovation, San Francisco Department of Public Health, San Francisco, CA University of California, San Francisco and National Health Laboratory Services, Cape Town, South Africa
    J Acquir Immune Defic Syndr 65:473-80. 2014
    ..However, few recent HIV-1 subtype data are available for MSM in South Africa. We examined HIV-1 subtypes among MSM in Cape Town...
  14. pmc Short communication decreased incidence of dual infections in South african subtype C-infected women compared to a cohort ten years earlier
    Zenda Woodman
    Department of Molecular and Cell Biology, Faculty of Science, University of Cape Town, South Africa
    AIDS Res Hum Retroviruses 27:1167-72. 2011
    ..This study emphasized the importance of monitoring changes in the HIV epidemic as it may have important ramifications on our understanding of the natural history of disease...
  15. ncbi request reprint HIV type 1 subtype C gag and nef diversity in Southern Africa
    Helba Bredell
    Institute of Infectious Diseases and Molecular Medicine, University of Cape Town, Observatory, Cape Town, South Africa
    AIDS Res Hum Retroviruses 23:477-81. 2007
    ..We do not, however, find much evidence of intersubtype recombination in the Southern African genes, implying that the likelihood of vaccine failure due to the emergence of intersubtype recombinants is probably low...
  16. pmc Differential impact of magnitude, polyfunctional capacity, and specificity of HIV-specific CD8+ T cell responses on HIV set point
    Catherine Riou
    Division of Medical Virology, Institute of Infectious Disease and Molecular Medicine, Faculty of Health Sciences, University of Cape Town, Cape Town, South Africa
    J Virol 88:1819-24. 2014
    ..High frequencies of Gag and Nef responses endowed with four functions were the best predictors of a low viral set point. ..
  17. pmc Characterization of HIV-1 gag and nef in Cameroon: further evidence of extreme diversity at the origin of the HIV-1 group M epidemic
    Marcel Tongo
    Division of Medical Virology, University of Cape Town, Cape Town, South Africa
    Virol J 10:29. 2013
    ..Full length HIV gag and nef sequences were generated and phylogenetic analyses were performed...
  18. pmc HIV molecular epidemiology: transmission and adaptation to human populations
    Zenda Woodman
    Institute of Infectious Disease and Molecular Medicine, Division of Medical Virology, University of Cape Town, Observatory 7925, South Africa
    Curr Opin HIV AIDS 4:247-52. 2009
    ..To provide an update on the origin of the HIV epidemic and insights into how the immune response is shaping virus evolution...
  19. pmc Association of HIV-specific and total CD8+ T memory phenotypes in subtype C HIV-1 infection with viral set point
    Wendy A Burgers
    Division of Medical Virology, Faculty of Health Sciences, Institute of Infectious Diseases and Molecular Medicine, University of Cape Town, Cape Town, South Africa
    J Immunol 182:4751-61. 2009
    ..Thus, it is likely that a high Ag burden resulting in generalized immune activation may drive differentiation of HIV-specific and total memory CD8(+) T cells...
  20. ncbi request reprint Heterosexual transmission of multiple highly conserved viral variants in HIV-1 subtype C-infected seronegative women
    Cecilia Rademeyer
    Institute of Infectious Diseases and Molecular Medicine, Division of Medical Virology, University of Cape Town, Observatory 7925, Cape Town, South Africa
    AIDS 18:2096-8. 2004
    ..11% for p17p24, 0.32% for C2C3). In two individuals diversity was uncharacteristically lower in env C2C3 than in gag pl7p24, suggesting selection in env at this very early stage of infection...
  21. ncbi request reprint CTL response to HIV type 1 subtype C is poorly predicted by known epitope motifs
    Nobubelo G Ngandu
    Institute of Infectious Diseases and Molecular Medicine, Faculty of Health Sciences, University of Cape Town, Medical School, Observatory, South Africa 7925
    AIDS Res Hum Retroviruses 23:1033-41. 2007
    ..This can have important implications for understanding immune escape and predicting vaccine efficacy in the context of populations primarily infected with non-B subtype HIV-1...
  22. pmc Plasma cytokine levels during acute HIV-1 infection predict HIV disease progression
    Lindi Roberts
    Division of Medical Virology, Institute of Infectious Diseases and Molecular Medicine, University of Cape Town, South Africa
    AIDS 24:819-31. 2010
    ..Although the acute phase of HIV infection is associated with increased pro-inflammatory cytokine production, the relationship between cytokine concentrations and HIV pathogenesis is unknown...
  23. pmc Conserved positive selection signals in gp41 across multiple subtypes and difference in selection signals detectable in gp41 sequences sampled during acute and chronic HIV-1 subtype C infection
    Gama P Bandawe
    Institute of Infectious Disease and Molecular Medicine, University of Cape Town, Observatory, South Africa
    Virol J 5:141. 2008
    ..Besides being targeted by both the humoral and cellular arms of the immune system this protein mediates fusion between viral and target cell membranes and is likely to be a primary determinant of HIV transmissibility...
  24. pmc Intersubtype differences in the effect of a rare p24 gag mutation on HIV-1 replicative fitness
    Denis R Chopera
    Institute of Infectious Disease and Molecular Medicine, and the Division of Medical Virology, University of Cape Town and National Health Laboratory Services, Cape Town, South Africa
    J Virol 86:13423-33. 2012
    ..In addition to accounting for genetic differences between HIV-1 subtypes, the design of cytotoxic-T-lymphocyte-based vaccines may need to account for differential effects of host-driven viral evolution on viral fitness...
  25. pmc A novel candidate HIV vaccine vector based on the replication deficient Capripoxvirus, Lumpy skin disease virus (LSDV)
    Yen Ju Shen
    Institute of Infectious Disease and Molecular Medicine, UCT, Cape Town, South Africa
    Virol J 8:265. 2011
    ..The Capripoxvirus, Lumpy skin disease virus (LSDV) has a restricted host-range and is being investigated as a novel HIV-1 vaccine vector. LSDV does not complete its replication cycle in non-ruminant hosts...
  26. ncbi request reprint Striking lack of T cell immunodominance in both a multiclade and monoclade HIV-1 epidemic: implications for vaccine development
    Marcel Tongo
    Division of Medical Virology, Institute of Infectious Disease and Molecular Medicine, University of Cape Town, Cape Town, South Africa Institute of Medical Research and Study of Medicinal Plants, Yaounde, Cameroon
    Vaccine 32:2328-36. 2014
    ..The central nature of HIV-1 consensus M sequences resulted in their broad recognition, but failed to identify highly immunodominant peptides between homogeneous and diverse HIV epidemics. ..
  27. ncbi request reprint Incidence of HIV-1 dual infection and its association with increased viral load set point in a cohort of HIV-1 subtype C-infected female sex workers
    Jandre Grobler
    Institute for Infectious Diseases and Molecular Medicine, Division of Medical Virology, University of Cape Town, Observatory, South Africa
    J Infect Dis 190:1355-9. 2004
    ..There was a significant association between dual infection and elevated viral load set point...
  28. ncbi request reprint Defining the human immunodeficiency virus type 1 transmission genetic bottleneck in a region with multiple circulating subtypes and recombinant forms
    Andile Nofemela
    Institute of Infectious Disease and Molecular Medicine, Division of Medical Virology, Faculty of Health Sciences, University of Cape Town, Anzio Road, Observatory 7925, South Africa
    Virology 415:107-13. 2011
    ....
  29. ncbi request reprint Construction and characterisation of a candidate HIV-1 subtype C DNA vaccine for South Africa
    Joanne H van Harmelen
    Institute for Infectious Diseases and Molecular Medicine, University of Cape Town, Observatory, Cape Town 7925, South Africa
    Vaccine 21:4380-9. 2003
    ..This is the first candidate HIV-1 DNA vaccine employing the South African subtype C sequences, and constitutes a part of a vaccine scheduled to enter a clinical evaluation in South Africa in 2004...
  30. pmc Intra- and inter-clade cross-reactivity by HIV-1 Gag specific T-cells reveals exclusive and commonly targeted regions: implications for current vaccine trials
    Lycias Zembe
    Division of Medical Virology, Institute of Infectious Disease and Molecular Medicine, University of Cape Town, Cape Town, South Africa
    PLoS ONE 6:e26096. 2011
    ....
  31. pmc CAPRISA 004 tenofovir microbicide trial: no impact of tenofovir gel on the HIV transmission bottleneck
    Ziyaad Valley-Omar
    Institute of Infectious Diseases and Molecular Medicine, Division of Medical Virology, University of Cape Town, Cape Town
    J Infect Dis 206:35-40. 2012
    ..37). Tenofovir gel had no discernable impact on the transmission bottleneck...
  32. ncbi request reprint The challenges of HIV vaccine development and testing
    Wendy A Burgers
    Institute of Infectious Disease and Molecular Medicine, Faculty of Health Sciences, University of Cape Town, Observatory 7925, Cape Town, South Africa
    Best Pract Res Clin Obstet Gynaecol 19:277-91. 2005
    ..These trials need to take place in the developing countries that bear the burden of the epidemic, requiring a substantial amount of infrastructure development and capacity building...
  33. ncbi request reprint Investigation of HIV in amniotic fluid from HIV-infected pregnant women at full term
    Boshishi K F Mohlala
    Department of Obstetrics and Gynaecology, Institute for Infectious Diseases and Molecular Medicine, University of Cape Town, South Africa
    J Infect Dis 192:488-91. 2005
    ..In the absence of interventions and breast-feeding, the in utero transmission rate of human immunodeficiency virus (HIV) is estimated to be 10%-15%, and the role that amniotic fluid (AF) plays in this is unclear...
  34. ncbi request reprint Characterization and selection of HIV-1 subtype C isolates for use in vaccine development
    Carolyn Williamson
    Division of Medical Virology, University of Cape Town, Observatory, Cape Town, South Africa 7925
    AIDS Res Hum Retroviruses 19:133-44. 2003
    ..Genes identified in this study have been incorporated into the VEE VRP candidate vaccines targeted for clinical trial in South Africa...