Renate Strehlau

Summary

Affiliation: University of the Witwatersrand
Country: South Africa

Publications

  1. pmc Absence seizures associated with efavirenz initiation
    Renate Strehlau
    Empilweni Services and Research Unit ESRU, Rahima Moosa Mother and Child Hospital, Johannesburg, South Africa
    Pediatr Infect Dis J 30:1001-3. 2011
  2. pmc Sex differences in responses to antiretroviral treatment in South African HIV-infected children on ritonavir-boosted lopinavir- and nevirapine-based treatment
    Stephanie Shiau
    Gertrude H, Sergievsky Center, College of Physicians and Surgeons, Columbia University, New York, NY USA
    BMC Pediatr 14:39. 2014
  3. pmc Genetic Changes in HIV-1 Gag-Protease Associated with Protease Inhibitor-Based Therapy Failure in Pediatric Patients
    Jennifer Giandhari
    1 Centre for HIV and STIs, National Institute for Communicable Diseases NICD, Johannesburg, South Africa
    AIDS Res Hum Retroviruses 31:776-82. 2015
  4. pmc Young age at start of antiretroviral therapy and negative HIV antibody results in HIV-infected children when suppressed
    Louise Kuhn
    aGertrude H Sergievsky Center, College of Physicians and Surgeons bDepartment of Epidemiology, Mailman School of Public Health, Columbia University, New York, New York, USA cCentre for HIV and STIs, National Institute for Communicable Diseases dEmpilweni Services and Research Unit, Rahima Moosa Mother and Child Hospital, Faculty of Health Sciences, University of the Witwatersrand, Johannesburg, South Africa eICAP, Mailman School of Public Health, Columbia University, New York, New York, USA
    AIDS 29:1053-60. 2015
  5. pmc Case report: Severe central nervous system manifestations associated with aberrant efavirenz metabolism in children: the role of CYP2B6 genetic variation
    Francoise Pinillos
    Empilweni Services and Research Unit ESRU, Rahima Moosa Mother and Child Hospital, Department of Paediatrics and Child Health, Faculty of Health Sciences, University of the Witwatersrand, Johannesburg, South Africa
    BMC Infect Dis 16:56. 2016
  6. pmc Timing of maternal HIV testing and uptake of prevention of mother-to-child transmission interventions among women and their infected infants in Johannesburg, South Africa
    Karl Günter Technau
    Empilweni Services and Research Unit, Department of Paediatrics and Child Health, Rahima Moosa Mother and Child Hospital, Faculty of Health Sciences, University of the Witwatersrand, Johannesburg, South Africa Centre for Infectious Disease Epidemiology and Research, School of Public Health and Family Medicine, Faculty of Health Sciences, University of Cape Town, Cape Town, South Africa Wits Reproductive Health and HIV Institute, Faculty of Health Sciences, University of Witwatersrand, Johannesburg, South Africa HIV Center for Clinical and Behavioral Studies, Division of Gender Sexuality and Health, Department of Psychiatry, Columbia University and the New York State Psychiatric Institute, New York, NY ICAP, Mailman School of Public Health, and Department of Pediatrics, College of Physicians and Surgeons, Columbia University, New York, NY and Gertrude H Sergievsky Center, College of Physicians and Surgeons, and Department of Epidemiology, Mailman School of Public Health, Columbia University, New York, NY
    J Acquir Immune Defic Syndr 65:e170-8. 2014
  7. pmc Poor early virologic performance and durability of abacavir-based first-line regimens for HIV-infected children
    Karl Günter Technau
    Empilweni Services and Research Unit, Department of Paediatrics and Child Health, Rahima Moosa Mother and Child Hospital, Coronationville, Johannesburg, Gauteng, South Africa
    Pediatr Infect Dis J 32:851-5. 2013
  8. pmc Lipid profiles in young HIV-infected children initiating and changing antiretroviral therapy
    Renate Strehlau
    Empilweni Services and Research Unit, Rahima Moosa Mother and Child Hospital, University of the Witwatersrand, Johannesburg, South Africa
    J Acquir Immune Defic Syndr 60:369-76. 2012
  9. pmc Efavirenz-Based Antiretroviral Therapy Among Nevirapine-Exposed HIV-Infected Children in South Africa: A Randomized Clinical Trial
    Ashraf Coovadia
    Empilweni Services and Research Unit, Rahima Moosa Mother and Child Hospital, Faculty of Health Sciences, University of the Witwatersrand, Johannesburg, South Africa
    JAMA 314:1808-17. 2015
  10. pmc Concordance between allele-specific PCR and ultra-deep pyrosequencing for the detection of HIV-1 non-nucleoside reverse transcriptase inhibitor resistance mutations
    Gillian M Hunt
    Centre for HIV and STIs, National Institute for Communicable Diseases of the National Health Laboratory Service, Johannesburg, South Africa Faculty of Health Sciences, University of the Witwatersrand, Johannesburg, South Africa Electronic address
    J Virol Methods 207:182-7. 2014

Collaborators

Detail Information

Publications10

  1. pmc Absence seizures associated with efavirenz initiation
    Renate Strehlau
    Empilweni Services and Research Unit ESRU, Rahima Moosa Mother and Child Hospital, Johannesburg, South Africa
    Pediatr Infect Dis J 30:1001-3. 2011
    ..Plasma efavirenz values were above therapeutic range. The child was homozygous for the CYP2B6-516T/T genotype, which is associated with poor efavirenz clearance. Seizures abated after efavirenz discontinuation...
  2. pmc Sex differences in responses to antiretroviral treatment in South African HIV-infected children on ritonavir-boosted lopinavir- and nevirapine-based treatment
    Stephanie Shiau
    Gertrude H, Sergievsky Center, College of Physicians and Surgeons, Columbia University, New York, NY USA
    BMC Pediatr 14:39. 2014
    ..The objective of this study was to evaluate for sex differences in response to ART in South African HIV-infected children who were randomized to continue ritonavir-boosted lopinavir (LPV/r)-based ART or switch to nevirapine-based ART...
  3. pmc Genetic Changes in HIV-1 Gag-Protease Associated with Protease Inhibitor-Based Therapy Failure in Pediatric Patients
    Jennifer Giandhari
    1 Centre for HIV and STIs, National Institute for Communicable Diseases NICD, Johannesburg, South Africa
    AIDS Res Hum Retroviruses 31:776-82. 2015
    ..Changes in Gag during PI failure therefore warrant further investigation of the Gag gene and its role in PI failure in HIV-1 subtype C infection. ..
  4. pmc Young age at start of antiretroviral therapy and negative HIV antibody results in HIV-infected children when suppressed
    Louise Kuhn
    aGertrude H Sergievsky Center, College of Physicians and Surgeons bDepartment of Epidemiology, Mailman School of Public Health, Columbia University, New York, New York, USA cCentre for HIV and STIs, National Institute for Communicable Diseases dEmpilweni Services and Research Unit, Rahima Moosa Mother and Child Hospital, Faculty of Health Sciences, University of the Witwatersrand, Johannesburg, South Africa eICAP, Mailman School of Public Health, Columbia University, New York, New York, USA
    AIDS 29:1053-60. 2015
    ..Here, we describe the frequency and predictors of this phenomenon in a well characterized cohort of treated children...
  5. pmc Case report: Severe central nervous system manifestations associated with aberrant efavirenz metabolism in children: the role of CYP2B6 genetic variation
    Francoise Pinillos
    Empilweni Services and Research Unit ESRU, Rahima Moosa Mother and Child Hospital, Department of Paediatrics and Child Health, Faculty of Health Sciences, University of the Witwatersrand, Johannesburg, South Africa
    BMC Infect Dis 16:56. 2016
    ..None of the children had a CYP2B6 wildtype haplotype. We believe this is the first case of cerebellar dysfunction associated with efavirenz use to be described in children...
  6. pmc Timing of maternal HIV testing and uptake of prevention of mother-to-child transmission interventions among women and their infected infants in Johannesburg, South Africa
    Karl Günter Technau
    Empilweni Services and Research Unit, Department of Paediatrics and Child Health, Rahima Moosa Mother and Child Hospital, Faculty of Health Sciences, University of the Witwatersrand, Johannesburg, South Africa Centre for Infectious Disease Epidemiology and Research, School of Public Health and Family Medicine, Faculty of Health Sciences, University of Cape Town, Cape Town, South Africa Wits Reproductive Health and HIV Institute, Faculty of Health Sciences, University of Witwatersrand, Johannesburg, South Africa HIV Center for Clinical and Behavioral Studies, Division of Gender Sexuality and Health, Department of Psychiatry, Columbia University and the New York State Psychiatric Institute, New York, NY ICAP, Mailman School of Public Health, and Department of Pediatrics, College of Physicians and Surgeons, Columbia University, New York, NY and Gertrude H Sergievsky Center, College of Physicians and Surgeons, and Department of Epidemiology, Mailman School of Public Health, Columbia University, New York, NY
    J Acquir Immune Defic Syndr 65:e170-8. 2014
    ..7%. We investigated the profile of newly diagnosed vertically infected children and their mothers to identify shortfalls in the PMTCT program...
  7. pmc Poor early virologic performance and durability of abacavir-based first-line regimens for HIV-infected children
    Karl Günter Technau
    Empilweni Services and Research Unit, Department of Paediatrics and Child Health, Rahima Moosa Mother and Child Hospital, Coronationville, Johannesburg, Gauteng, South Africa
    Pediatr Infect Dis J 32:851-5. 2013
    ..Concerns about stavudine (d4T) toxicity have led to increased use of abacavir (ABC) in first-line pediatric antiretroviral treatment (ART) regimens. Field experience with ABC in ART-naïve children is limited...
  8. pmc Lipid profiles in young HIV-infected children initiating and changing antiretroviral therapy
    Renate Strehlau
    Empilweni Services and Research Unit, Rahima Moosa Mother and Child Hospital, University of the Witwatersrand, Johannesburg, South Africa
    J Acquir Immune Defic Syndr 60:369-76. 2012
    ..Here we examined lipid profile changes in a cohort of young children before and after suppression on an initial ritonavir-boosted lopinavir (LPV/r)-based regimen and after switch to a nevirapine (NVP)-based regimen...
  9. pmc Efavirenz-Based Antiretroviral Therapy Among Nevirapine-Exposed HIV-Infected Children in South Africa: A Randomized Clinical Trial
    Ashraf Coovadia
    Empilweni Services and Research Unit, Rahima Moosa Mother and Child Hospital, Faculty of Health Sciences, University of the Witwatersrand, Johannesburg, South Africa
    JAMA 314:1808-17. 2015
    ..However, there have been concerns about possible reduced viral efficacy of efavirenz in children exposed to nevirapine for prevention of mother-to-child transmission...
  10. pmc Concordance between allele-specific PCR and ultra-deep pyrosequencing for the detection of HIV-1 non-nucleoside reverse transcriptase inhibitor resistance mutations
    Gillian M Hunt
    Centre for HIV and STIs, National Institute for Communicable Diseases of the National Health Laboratory Service, Johannesburg, South Africa Faculty of Health Sciences, University of the Witwatersrand, Johannesburg, South Africa Electronic address
    J Virol Methods 207:182-7. 2014
    ..Overall, both AS-PCR and ultra-deep pyrosequencing methods have proven to be sensitive and accurate, and may confidently be used where feasible. ..