Helena Rabie

Summary

Affiliation: University of Stellenbosch
Country: South Africa

Publications

  1. pmc Tuberculosis: opportunities and challenges for the 90-90-90 targets in HIV-infected children
    Helena Rabie
    Division of Infectious Diseases, Department of Paediatrics and Child Health, Faculty of Medicine and Health Sciences, Stellenbosch University and Tygerberg Hospital, Tygerberg, South Africa
    J Int AIDS Soc 18:20236. 2015
  2. pmc Early Antiretroviral Therapy reduces the incidence of otorrhea in a randomized study of early and deferred antiretroviral therapy: Evidence from the Children with HIV Early Antiretroviral Therapy (CHER) Study
    Clotilde Hainline
    Department of Paediatrics and Child Health and Children s Infectious Diseases Clinical Research Unit KID CRU, Tygerberg Children s Hospital and Faculty of Health Sciences, Stellenbosch University, Tygerberg, South Africa
    BMC Res Notes 4:448. 2011
  3. ncbi request reprint Children with human immunodeficiency virus infection admitted to a paediatric intensive care unit in South Africa
    Helena Rabie
    Department of Paediatrics and Child Health Tygerberg Children s Hospital and Stellenbosch University, South Africa
    J Trop Pediatr 53:270-3. 2007
  4. pmc Early antiretroviral treatment reduces risk of bacille Calmette-Guérin immune reconstitution adenitis
    H Rabie
    Children s Infectious Diseases Clinical Research Unit, Department of Paediatrics and Child Health, Stellenbosch University and Tygerberg Children s Hospital, Cape Town, South Africa
    Int J Tuberc Lung Dis 15:1194-200, i. 2011
  5. doi request reprint Paradoxical tuberculosis associated immune reconstitution inflammatory syndrome presenting with chylous ascites and chylothorax in a HIV-1 infected child
    Helena Rabie
    Tygerberg Children s Hospital and University of Stellenbosch, Pediatrics and Child Health, South Africa
    J Trop Pediatr 56:355-8. 2010
  6. pmc The role of targeted viral load testing in diagnosing virological failure in children on antiretroviral therapy with immunological failure
    Mary Ann Davies
    School of Public Health and Family Medicine, University of Cape Town, Cape Town, South Africa Empilweni Service and Research Unit, Rahima Moosa Mother and Child Hospital and University of Witwatersrand, Johannesburg, South Africa Red Cross Children s Hospital and School of Child and Adolescent Health, University of Cape Town, Cape Town, South Africa Wits Reproductive Health and HIV Institute Harriet Shezi Children s Clinic, Chris Hani Baragwanath Hospital, Soweto, Faculty of Health Sciences, University of Witwatersrand, Johannesburg, South Africa Tygerberg Academic Hospital, University of Stellenbosch, Stellenbosch, South Africa Médecins Sans Frontières South Africa and Khayelitsha ART Programme, Khayelitsha, Cape Town, South Africa Sinikithemba Clinic, McCord Hospital, Durban, South Africa Gugulethu Community Health Centre and Desmond Tutu HIV Centre, Institute of Infectious Diseases and Molecular Medicine, University of Cape Town, Cape Town, South Africa Institute of Social and Preventive Medicine ISPM, University of Bern, Bern, Switzerland
    Trop Med Int Health 17:1386-90. 2012
  7. pmc Accuracy of immunological criteria for identifying virological failure in children on antiretroviral therapy - the IeDEA Southern Africa Collaboration
    Mary Ann Davies
    School of Public Health and Family Medicine, University of Cape Town, Cape Town, South Africa
    Trop Med Int Health 16:1367-71. 2011
  8. pmc When to start antiretroviral therapy in children aged 2-5 years: a collaborative causal modelling analysis of cohort studies from southern Africa
    Michael Schomaker
    Centre for Infectious Disease Epidemiology and Research, University of Cape Town, Cape Town, South Africa
    PLoS Med 10:e1001555. 2013
  9. doi request reprint Antiretroviral regimens containing a single protease inhibitor increase risk of virologic failure in young HIV-infected children
    Elisabetta Walters
    Department of Paediatrics and Child Health, Desmond Tutu TB Centre, Stellenbosch University, South Africa
    Pediatr Infect Dis J 32:361-3. 2013
  10. pmc Temporal trends in the characteristics of children at antiretroviral therapy initiation in southern Africa: the IeDEA-SA Collaboration
    Mary Ann Davies
    School of Public Health and Family Medicine, University of Cape Town, Cape Town, South Africa
    PLoS ONE 8:e81037. 2013

Detail Information

Publications47

  1. pmc Tuberculosis: opportunities and challenges for the 90-90-90 targets in HIV-infected children
    Helena Rabie
    Division of Infectious Diseases, Department of Paediatrics and Child Health, Faculty of Medicine and Health Sciences, Stellenbosch University and Tygerberg Hospital, Tygerberg, South Africa
    J Int AIDS Soc 18:20236. 2015
    ....
  2. pmc Early Antiretroviral Therapy reduces the incidence of otorrhea in a randomized study of early and deferred antiretroviral therapy: Evidence from the Children with HIV Early Antiretroviral Therapy (CHER) Study
    Clotilde Hainline
    Department of Paediatrics and Child Health and Children s Infectious Diseases Clinical Research Unit KID CRU, Tygerberg Children s Hospital and Faculty of Health Sciences, Stellenbosch University, Tygerberg, South Africa
    BMC Res Notes 4:448. 2011
    ..Medical records from one study site were reviewed for otorrhea...
  3. ncbi request reprint Children with human immunodeficiency virus infection admitted to a paediatric intensive care unit in South Africa
    Helena Rabie
    Department of Paediatrics and Child Health Tygerberg Children s Hospital and Stellenbosch University, South Africa
    J Trop Pediatr 53:270-3. 2007
    ..Recent studies report mortality of 38%. Survival depends on the indication for admission...
  4. pmc Early antiretroviral treatment reduces risk of bacille Calmette-Guérin immune reconstitution adenitis
    H Rabie
    Children s Infectious Diseases Clinical Research Unit, Department of Paediatrics and Child Health, Stellenbosch University and Tygerberg Children s Hospital, Cape Town, South Africa
    Int J Tuberc Lung Dis 15:1194-200, i. 2011
    ..Two centres in Soweto and Cape Town, South Africa...
  5. doi request reprint Paradoxical tuberculosis associated immune reconstitution inflammatory syndrome presenting with chylous ascites and chylothorax in a HIV-1 infected child
    Helena Rabie
    Tygerberg Children s Hospital and University of Stellenbosch, Pediatrics and Child Health, South Africa
    J Trop Pediatr 56:355-8. 2010
    ..There are few descriptions of TB IRIS in children. This case extends the clinical spectrum of TB IRIS...
  6. pmc The role of targeted viral load testing in diagnosing virological failure in children on antiretroviral therapy with immunological failure
    Mary Ann Davies
    School of Public Health and Family Medicine, University of Cape Town, Cape Town, South Africa Empilweni Service and Research Unit, Rahima Moosa Mother and Child Hospital and University of Witwatersrand, Johannesburg, South Africa Red Cross Children s Hospital and School of Child and Adolescent Health, University of Cape Town, Cape Town, South Africa Wits Reproductive Health and HIV Institute Harriet Shezi Children s Clinic, Chris Hani Baragwanath Hospital, Soweto, Faculty of Health Sciences, University of Witwatersrand, Johannesburg, South Africa Tygerberg Academic Hospital, University of Stellenbosch, Stellenbosch, South Africa Médecins Sans Frontières South Africa and Khayelitsha ART Programme, Khayelitsha, Cape Town, South Africa Sinikithemba Clinic, McCord Hospital, Durban, South Africa Gugulethu Community Health Centre and Desmond Tutu HIV Centre, Institute of Infectious Diseases and Molecular Medicine, University of Cape Town, Cape Town, South Africa Institute of Social and Preventive Medicine ISPM, University of Bern, Bern, Switzerland
    Trop Med Int Health 17:1386-90. 2012
    ....
  7. pmc Accuracy of immunological criteria for identifying virological failure in children on antiretroviral therapy - the IeDEA Southern Africa Collaboration
    Mary Ann Davies
    School of Public Health and Family Medicine, University of Cape Town, Cape Town, South Africa
    Trop Med Int Health 16:1367-71. 2011
    ....
  8. pmc When to start antiretroviral therapy in children aged 2-5 years: a collaborative causal modelling analysis of cohort studies from southern Africa
    Michael Schomaker
    Centre for Infectious Disease Epidemiology and Research, University of Cape Town, Cape Town, South Africa
    PLoS Med 10:e1001555. 2013
    ....
  9. doi request reprint Antiretroviral regimens containing a single protease inhibitor increase risk of virologic failure in young HIV-infected children
    Elisabetta Walters
    Department of Paediatrics and Child Health, Desmond Tutu TB Centre, Stellenbosch University, South Africa
    Pediatr Infect Dis J 32:361-3. 2013
    ..Ritonavir-based single protease inhibitor antiretroviral therapy regimen predicted virologic failure (adjusted odds ratio 3.7, 95% confidence interval 1.5-8.9, P = 0.004) on multivariate analysis...
  10. pmc Temporal trends in the characteristics of children at antiretroviral therapy initiation in southern Africa: the IeDEA-SA Collaboration
    Mary Ann Davies
    School of Public Health and Family Medicine, University of Cape Town, Cape Town, South Africa
    PLoS ONE 8:e81037. 2013
    ..We examined temporal changes in patient and regimen characteristics at ART start using data from 12 cohorts in 4 countries participating in the IeDEA-SA collaboration...
  11. pmc Prognosis of children with HIV-1 infection starting antiretroviral therapy in Southern Africa: a collaborative analysis of treatment programs
    Mary Ann Davies
    From the School of Public Health and Family Medicine, University of Cape Town, Cape Town, South Africa School of Social and Community Medicine, University of Bristol, Bristol, United Kingdom Centre for Infectious Disease Research in Zambia, Lusaka, Zambia University of North Carolina, Chapel Hill, NC Newlands clinic, Harare, Zimbabwe Red Cross Children s Hospital and School of Child and Adolescent Health, University of Cape Town Médecins Sans Frontières MSF South Africa and Khayelitsha ART Programme, Cape Town Sinikithemba Clinic, McCord Hospital, Durban Wits Reproductive Health and HIV Institute, University of the Witwatersrand, Johannesburg Harriet Shezi Children s Clinic, Chris Hani Baragwanath Hospital, Soweto Africa Centre for Health and Population Studies, University of KwaZulu Natal, Somkhele, South Africa Lighthouse Trust Clinic, Kamuzu Central Hospital, Lilongwe, Malawi and Liverpool School of Tropical Medicine, Liverpool, United Kingdom Tygerberg Academic Hospital, University of Stellenbosch, Stellenbosch Empilweni Services and Research Unit, Rahima Moosa Mother and Child Hospital, and University of the Witwatersrand, Johannesburg Gugulethu ART Programme and Desmond Tutu HIV Centre, University of Cape Town, Cape Town, South Africa and Institute of Social and Preventive Medicine ISPM, University of Bern, Japan
    Pediatr Infect Dis J 33:608-16. 2014
    ..Prognostic models for children starting antiretroviral therapy (ART) in Africa are lacking. We developed models to estimate the probability of death during the first year receiving ART in Southern Africa...
  12. pmc Biceps skin-fold thickness may detect and predict early lipoatrophy in HIV-infected children
    Steve Innes
    Children s Infectious Diseases Clinical Research Unit, Tygerberg Children s Hospital, and Department of Paediatrics, Stellenbosch University, Cape Town, South Africa
    Pediatr Infect Dis J 32:e254-62. 2013
    ..Early diagnosis of lipoatrophy is essential for effective intervention to arrest progression...
  13. pmc It is time to consider third-line options in antiretroviral-experienced paediatric patients?
    Gert U van Zyl
    Division of Medical Virology, Stellenbosch University, and National Health Laboratory Service Tygerberg, Parow, Cape Town, South Africa
    J Int AIDS Soc 14:55. 2011
    ..The historic use of full-dose ritonavir as part of an unboosted protease inhibitor (PI)-based antiretroviral therapy regimen in some South African children contributes to the frequent accumulation of major PI resistance mutations...
  14. doi request reprint Radiology services for children in HIV- and TB-endemic regions: scope for greater collaboration between radiologists and clinicians caring for children
    Angela Dramowski
    Department of Paediatrics and Child Health, Tygerberg Children s Hospital, Tygerberg, South Africa
    Pediatr Radiol 39:541-4. 2009
    ..The Child-Friendly Healthcare Initiative is discussed, emphasizing opportunities to promote child friendliness in radiology services...
  15. pmc Growth in Virologically Suppressed HIV-Positive Children on Antiretroviral Therapy: Individual and Population-level References
    Olivia Keiser
    From the Institute of Social and Preventive Medicine ISPM, University of Bern, Switzerland School of Public Health and Family Medicine, University of Cape Town, South Africa Leuven Institute for Research on Information Systems, KU Leuven, Belgium Department of Paediatrics and Child Health, Red Cross War Memorial Children s Hospital, University of Cape Town, Cape Town, South Africa Wits Reproductive Health and HIV Institute Harriet Shezi Children s Clinic, Chris Hani Baragwanath Hospital, Soweto, University of Witwatersrand, Johannesburg, South Africa Tygerberg Academic Hospital, University of Stellenbosch, Stellenbosch, South Africa Empilweni Services and Research Unit Rahima Moosa Mother and Child Hospital, Johannesburg and University of Witwatersrand, Johannesburg, South Africa Africa Centre for Health and Population Studies, University of KwaZulu Natal, Somkhele, South Africa Médecins Sans Frontières MSF South Africa, Khayelitsha, Cape Town, South Africa Sinikithemba Clinic, McCord Hospital, Johannesburg, South Africa and Kheth Impilo, Cape Town, South Africa
    Pediatr Infect Dis J 34:e254-9. 2015
    ..The growth of virologically suppressed children on ART has not been well documented. We aimed to develop dynamic reference curves for weight-for-age Z scores (WAZ) and height-for-age Z scores (HAZ)...
  16. doi request reprint Neurological manifestations of TB-IRIS: a report of 4 children
    Ronald van Toorn
    Department of Paediatrics and Child Health, Tygerberg Children s Hospital, Faculty of Health Sciences, Stellenbosch University, Francie van Zyl Avenue, Tygerberg 7550, Western Cape, South Africa
    Eur J Paediatr Neurol 16:676-82. 2012
    ..HIV-associated TB-IRIS has not been previously described in children with neurotuberculosis...
  17. pmc Early time-limited antiretroviral therapy versus deferred therapy in South African infants infected with HIV: results from the children with HIV early antiretroviral (CHER) randomised trial
    Mark F Cotton
    Children s Infectious Diseases Clinical Research Unit, Faculty of Medicine and Health Sciences, Stellenbosch University, Tygerberg, South Africa Electronic address
    Lancet 382:1555-63. 2013
    ..In view of the few treatment options and the potential toxicity associated with lifelong ART, in the CHER trial we compared early time-limited ART with deferred ART...
  18. pmc Reducing CD4 Monitoring in Children on Antiretroviral Therapy With Virologic Suppression
    Mary Ann Davies
    From the Centre for Infectious Disease Epidemiology and Research, School of Public Health and Family Medicine, University of Cape Town, Cape Town, South Africa HIV AIDS Department, World Health Organization, Geneva, Switzerland Tygerberg Academic Hospital, University of Stellenbosch, Stellenbosch, South Africa Kheth Impilo, Cape Town, South Africa Médecins Sans Frontières, Khayelitsha, South Africa McCord Hospital, Durban, South Africa Hlabisa HIV Program, South Africa Empilweni Services and Research Unit, Rahima Moosa Mother and Child Hospital, University of the Witwatersrand, Johannesburg, South Africa Wits Reproductive Health and HIV Institute, University of Witwatersrand, Johannesburg, South Africa Red Cross War Memorial Children s Hospital, University of Cape Town, Cape Town, South Africa Department of Paediatrics and Child Health, University of Cape Town, Cape Town, South Africa Gugulethu HIV Program, Desmond Tutu HIV Centre, University of Cape Town, Cape Town, South Africa Maternal and Pediatric Infectious Disease Branch, Eunice Kennedy Shriver National Institute of Child Health and Human Development NICHD, Bethesda, Maryland and Institute of Social and Preventive Medicine, University of Bern, Bern, Switzerland
    Pediatr Infect Dis J 34:1361-4. 2015
    ..Ongoing CD4 monitoring in patients on antiretroviral therapy (ART) with viral suppression has been questioned. We evaluated the probability of CD4 decline in children with viral suppression and CD4 recovery after 1 year on ART...
  19. pmc Virologic response in children treated with abacavir-compared with stavudine-based antiretroviral treatment: a South African multi-cohort analysis
    Karl Günter Technau
    From the Empilweni Services and Research Unit, Department of Paediatrics and Child Health, Rahima Moosa Mother and Child Hospital, Faculty of Health Sciences, University of the Witwatersrand School of Public Health and Family Medicine, University of Cape Town, Cape Town Gertrude H Sergievsky Center, College of Physicians and Surgeons, Department of Epidemiology, Mailman School of Public Health, Columbia University, New York, NY Wits Reproductive Health and HIV Institute Harriet Shezi Children s Clinic, Chris Hani Baragwanath Hospital, Soweto, Faculty of Health Sciences, University of Witwatersrand, Johannesburg Department of Paediatrics and Child Health, Red Cross War Memorial Children s Hospital, The University of Cape Town, Cape Town Tygerberg Academic Hospital, University of Stellenbosch, Stellenbosch Gugulethu Community Health Centre and Desmond Tutu HIV Centre, Institute of Infectious Diseases and Molecular Medicine, University of Cape Town Médecins Sans Frontières South Africa and Khayelitsha ART Programme, Khayelitsha, Cape Town, South Africa and Institute of Social and Preventive Medicine ISPM, University of Bern, Bern, Switzerland
    Pediatr Infect Dis J 33:617-22. 2014
    ..We reported worse early virological outcomes associated with the use of abacavir (ABC)-based regimens at 1 large site: here, we expand this analysis to multiple sites in the IeDEA-Southern Africa collaboration...
  20. pmc Virologic failure and second-line antiretroviral therapy in children in South Africa--the IeDEA Southern Africa collaboration
    Mary Ann Davies
    School of Public Health and Family Medicine, Faculty of Health Sciences, University of Cape Town, Cape Town, South Africa
    J Acquir Immune Defic Syndr 56:270-8. 2011
    ..We evaluated the probability and determinants of virologic failure and switching in children in South Africa...
  21. ncbi request reprint Opsoclonus-myoclonus in an HIV-infected child on antiretroviral therapy--possible immune reconstitution inflammatory syndrome
    Ronald van Toorn
    Department of Pediatrics and Child Health, Faculty of Health Sciences, Stellenbosch University and Tygerberg Children s Hospital, P O Box 19063, Tygerberg 7505, Clinical Building 2nd Floor, Tygerberg, Western Cape, South Africa
    Eur J Paediatr Neurol 9:423-6. 2005
    ..Single photon emission computed tomography (SPECT) proved helpful by localizing the area of dysfunction to the cerebellar vermis...
  22. pmc Incidence of AIDS-defining and Other Cancers in HIV-positive Children in South Africa: Record Linkage Study
    Julia Bohlius
    From the Institute of Social and Preventive Medicine, University of Bern, Bern, Switzerland School of Public Health and Family Medicine, University of Cape Town, Cape Town, South Africa Department of Paediatrics and Child Health, Chris Hani Baragwanath Academic Hospital, South Africa Harriet Shezi Children s Clinic, University of the Witwatersrand, WITS Reproductive Health and HIV Institute, Johannesburg, South Africa Department of Paediatrics and Child Health, Charlotte Maxeke Johannesburg Academic Hospital, University of the Witwatersrand, Johannesburg, South Africa Paediatric Infectious Diseases Unit, Red Cross War Memorial Children s Hospital Department of Paediatrics and Child Health, University of Cape Town, Cape Town, South Africa Division of Infectious Diseases, Department of Medicine, University of Stellenbosch and Tygerberg Academic Hospital, Cape Town, South Africa Department of Paediatrics and Child Health, Tygerberg Hospital and Stellenbosch University, Tygerberg, Cape Town, South Africa Khayelitsha ART Program, Medecins Sans Frontieres, Cape Town, South Africa Empilweni Services and Research Unit, Rahima Moosa Mother and Child Hospital, University of the Witwatersrand, Johannesburg, South Africa Health Economics and Epidemiology Research Office, Department of Internal Medicine, School of Clinical Medicine, Faculty of Health Sciences, University of the Witwatersrand, Johannesburg, Charlottesville
    Pediatr Infect Dis J 35:e164-70. 2016
    ..Little is known on the risk of cancer in HIV-positive children in sub-Saharan Africa. We examined incidence and risk factors of AIDS-defining and other cancers in pediatric antiretroviral therapy (ART) programs in South Africa...
  23. pmc Outcomes of Infants Starting Antiretroviral Therapy in Southern Africa, 2004-2012
    Mireille Porter
    School of Public Health and Family Medicine, University of Cape Town, Cape Town, South Africa MMed Paeds and Child Health UNZA, Centre for Infectious Disease Research in Zambia, Lusaka, Zambia Tygerberg Academic Hospital and Stellenbosch University, Cape Town, South Africa Lighthouse Trust Clinic, Lilongwe, Malawi Red Cross War Memorial Children s Hospital, Cape Town, South Africa School of Child and Adolescent Health, University of Cape Town, Cape Town, South Africa Wits Reproductive Health and HIV Institute Wits RHI, University of the Witwatersrand, Johannesburg, South Africa Empilweni Services and Research Unit, Department of Paediatrics and Child Health, Rahima Moosa Mother and Child Hospital and University of the Witwatersrand, Johannesburg, South Africa Médecins Sans Frontières, Khayelitsha and School of Public Health and Family Medicine, University of Cape Town, Cape Town, South Africa Gugulethu Community Health Centre and Desmond Tutu HIV Centre, Institute of Infectious Diseases and Molecular Medicine, University of Cape Town, Cape Town, South Africa Newlands Clinic, Harare, Zimbabwe Institute of Social and Preventive Medicine ISPM, University of Bern, Bern, Switzerland McCord Hospital, Durban, South Africa and Africa Centre for Health and Population Studies, University of KwaZulu Natal, Somkhele, USA
    J Acquir Immune Defic Syndr 69:593-601. 2015
    ..There are limited published data on the outcomes of infants starting antiretroviral therapy (ART) in routine care in Southern Africa. This study aimed to examine the baseline characteristics and outcomes of infants initiating ART...
  24. pmc Minimizing the risk of non-vertical, non-sexual HIV infection in children--beyond mother to child transmission
    Mark F Cotton
    Division of Paediatric Infectious Diseases, Tygerberg Children s Hospital, Stellenbosch University, Cape Town, South Africa
    J Int AIDS Soc 15:17377. 2012
    ....
  25. ncbi request reprint Acute demyelinating encephalomyelitis (ADEM), cryptococcal reactivation and disseminated Herpes simplex in an HIV infected child following HAART
    Ronald van Toorn
    Department of Pediatrics and Child Health, Faculty of Health Sciences, Stellenbosch University and Tygerberg Children s Hospital, P O Box 19063, Tygerberg 7505, South Africa
    Eur J Paediatr Neurol 9:355-9. 2005
    ....
  26. doi request reprint Protease inhibitor resistance in South African children with virologic failure
    Gert U van Zyl
    Centre for Infectious Diseases, Division of Medical Virology, Tygerberg and Stellenbosch University, Cape Town, South Africa
    Pediatr Infect Dis J 28:1125-7. 2009
    ..We explored antiretroviral resistance mutations in pediatric patients failing PI-based antiretroviral therapy and the predictors of major PI resistance mutations (MPIRM) in these patients...
  27. doi request reprint Antiretroviral Treatment Initiated in the First Month of Life
    Lisa Frigati
    1Division of Paediatric Infectious Diseases and Department of Paediatrics and Child Health, Tygerberg Children s Hospital, Faculty of Medicine and Health Sciences, Stellenbosch University, Stellenbosch, South Africa 2School of Medicine, Imperial College London 3Division of Medical Virology, Department of Pathology, Stellenbosch University and the National Health Laboratory Service, Tygerberg Hospital 4Division of Neonatology and Department of Paediatrics and Child Health, Tygerberg Children s Hospital, Faculty of Medicine and Health Sciences, Stellenbosch University, Stellenbosch, South Africa
    Pediatr Infect Dis J . 2016
    ..Earlier diagnosis of HIV-infected infants facilitates earlier access to therapy and improved clinical outcomes...
  28. doi request reprint Severe manifestations of extrapulmonary tuberculosis in HIV-infected children initiating antiretroviral therapy before 2 years of age
    Elisabetta Walters
    Department of Paediatrics and Child Health, Desmond Tutu TB Centre, Stellenbosch University, Cape Town, South Africa
    Arch Dis Child 99:998-1003. 2014
    ..However, young HIV-infected children remain at high risk of TB disease following mycobacterial infection. We document the spectrum of TB disease in HIV-infected children <2 years of age on ART...
  29. ncbi request reprint Malaria in children--prevention and management
    Angela Dramowski
    Department of Paediatrics and Child Health, Division of Paediatric Infectious Diseases, Tygerberg Children s Hospital, Stellenbosch University, South Africa
    Infect Disord Drug Targets 13:303-11. 2013
    ..This special issue review is aimed at paediatric clinicians in resource-poor settings and provides a summary of recent data from paediatric trials of malaria treatment and prevention interventions. ..
  30. doi request reprint Trough lopinavir concentrations in preterm HIV-infected infants
    Sandi L Holgate
    Department of Pediatrics and Child Health, Tygerberg Children s Hospital and Stellenbosch University, Cape Town, South Africa
    Pediatr Infect Dis J 31:602-4. 2012
    ..The median age at initiation was 27 days. Trough values guided dosing. Five infants needed doses above 300 mg/m. Although no adverse events were noted, lopinavir usage requires caution and careful monitoring...
  31. pmc Clinical presentation and outcome of tuberculosis in human immunodeficiency virus infected children on anti-retroviral therapy
    Elisabetta Walters
    Department of Pediatrics and Child Health, Faculty of Health Sciences, Stellenbosch University, Cape Town, South Africa
    BMC Pediatr 8:1. 2008
    ..Little is known about the clinical presentation and outcome of TB in HIV-infected children on HAART...
  32. doi request reprint A retrospective study of cryptosporidial diarrhea in a region with high HIV prevalence
    Etienne D Nel
    Department of Pediatrics and Child Health, Faculty of Health Sciences, Stellenbosch University and Tygerberg Academic Hospital, Cape Town, 7505, South Africa
    J Trop Pediatr 57:289-92. 2011
    ..1) for uninfected children. Cryptosporidium is an important cause of diarrhea among younger children in the Western Cape, which occurs more frequently during the dry months of the year and has a worse outcome in HIV-infected children...
  33. ncbi request reprint Paediatric antiretroviral drug targets
    Amy Slogrove
    Department of Pediatrics and Child Health, Faculty of Health Sciences, Stellenbosch University, Tygerberg, South Africa
    Infect Disord Drug Targets 11:115-23. 2011
    ..Also, there are many practical challenges to administering these agents to children...
  34. pmc Incidence rate of Kaposi sarcoma in HIV-infected patients on antiretroviral therapy in Southern Africa: a prospective multicohort study
    Eliane Rohner
    Institute of Social and Preventive Medicine ISPM, University of Bern, Bern, Switzerland Health Economics and Epidemiology Research Office, Department of Internal Medicine, School of Clinical Medicine, Faculty of Health Sciences, University of the Witwatersrand, Johannesburg, South Africa Division of Infectious Diseases, Department of Medicine, University of Stellenbosch and Tygerberg Academic Hospital, Cape Town, South Africa Department of Pediatrics and Child Health, University of Stellenbosch and Tygerberg Academic Hospital, Cape Town, South Africa Khayelitsha ART Program, Medecins Sans Frontieres, Cape Town, South Africa Independent Surgery, Gaborone, Botswana Newlands Clinic, Harare, Zimbabwe Centre for Infectious Disease Research in Zambia CIDRZ, Lusaka, Zambia Boston University School of Medicine, Section of Geriatrics, Boston, MA, USA and Centre for Infectious Disease Epidemiology and Research CIDER, University of Cape Town, Cape Town, South Africa
    J Acquir Immune Defic Syndr 67:547-54. 2014
    ..We studied KS incidence rates and associated risk factors in children and adults on ART in Southern Africa...
  35. pmc Trends in paediatric bloodstream infections at a South African referral hospital
    Angela Dramowski
    Department of Paediatrics and Child Health, Division of Paediatric Infectious Diseases, Faculty of Medicine and Health Sciences, Stellenbosch University, PO Box 19063, Tygerberg, 7505, South Africa
    BMC Pediatr 15:33. 2015
    ..The epidemiology of paediatric bloodstream infection (BSI) in Sub-Saharan Africa is poorly documented with limited data on hospital-acquired sepsis, impact of HIV infection, BSI trends and antimicrobial resistance...
  36. pmc High prevalence of lipoatrophy in pre-pubertal South African children on antiretroviral therapy: a cross-sectional study
    Steve Innes
    Department of Paediatrics, Children s Infectious Diseases Clinical Research Unit KID CRU, Tygerberg Children s Hospital, Stellenbosch University, Cape Town, South Africa
    BMC Pediatr 12:183. 2012
    ..Lipoatrophy in sub-Saharan African children can be stigmatizing and have far-reaching consequences. The severity and extent of lipoatrophy in pre-pubertal children living in sub-Saharan Africa is unknown...
  37. doi request reprint Presumed cytomegalovirus retinitis in human immunodeficiency virus type I-infected South African children
    Natasha O'connell
    Department of Paediatrics and Child Health, Tygerberg Children s Hospital, Stellenbosch University, Cape Town, South Africa
    Pediatr Infect Dis J 30:539-40. 2011
    ..Of the 6 children, 5 had clinical features suggesting ocular disease at presentation. The child in whom retinitis was detected through preemptive screening due to systemic disease achieved normal visual outcome...
  38. doi request reprint Pediatric and adolescent imported malaria in Cape Town
    Taryn C Gray
    Department of Pediatrics and Child Health, Faculty of Health Sciences, Stellenbosch University, Cape Town, South Africa
    Pediatr Infect Dis J 28:644-6. 2009
    ..Rapid diagnosis occurred in most cases. Eleven of 42 (26%) had severe malaria. Management issues included delay to and inappropriate treatment, inadequate monitoring for hypoglycemia, and under notification to health authorities...
  39. ncbi request reprint Poverty and human immunodeficiency virus in children: a view from the Western Cape, South Africa
    Barend Jacobus Marais
    Department of Paediatrics and Child Health, Faculty of Health Sciences, Tygerberg Children s Hospital, Stellenbosch University, Tygerberg, South Africa
    Ann N Y Acad Sci 1136:21-7. 2008
    ..The formulation of the United Nations Millennium Developmental Goals is an important step in the right direction, but global and local political commitment is essential for success...
  40. pmc Nocardia pneumonia in an HIV-infected neonate presenting as acute necrotising pneumonia
    Pierre Goussard
    Department of Paediatrics and Child Health, Stellenbosch University, Tygerberg Children s Hospital, Cape Town, South Africa
    BMJ Case Rep 2013:. 2013
    ..We describe an expansile necrotising pneumonia caused by Norcardia in a HIV-infected 3-week-old baby. The radiological images and treatment of Norcardia in immune deficient children are discussed. ..
  41. pmc The last and first frontier--emerging challenges for HIV treatment and prevention in the first week of life with emphasis on premature and low birth weight infants
    Mark F Cotton
    Division of Paediatric Infectious Diseases, Department of Paediatrics and Child Health, Faculty of Medicine and Health Sciences, Tygerberg Children s Hospital, Stellenbosch University, Stellenbosch, South Africa
    J Int AIDS Soc 18:20271. 2015
    ..As HIV programs expand to meet the 90-90-90 target for ending the HIV pandemic, attention should focus on newborn infants, including those delivered preterm or of LBW...
  42. doi request reprint Complicated and protracted cryptococcal disease in HIV-infected children
    Haseena Hassan
    From the Department of Paediatrics and Child Health, Stellenbosch University and Tygerberg Children s Hospital and Children s Infectious Diseases Research Unit KIDCRU, Stellenbosch University, Tygerberg, Cape Town, South Africa
    Pediatr Infect Dis J 34:62-5. 2015
    ..Immune reconstitution inflammatory syndrome contributed to morbidity through exacerbations at the primary site and elsewhere. ..
  43. pmc Impact of earlier combination antiretroviral therapy on outcomes in children
    Mark F Cotton
    Division of Paediatric Infectious Diseases, Department of Pediatrics and Child Health, Stellenbosch University and Tygerberg Children s Hospital, Tygerberg, Cape Town, South Africa
    Curr Opin HIV AIDS 10:12-7. 2015
    ..A recent report of transient HIV remission in a child beginning ART from the second day of life has focused attention on very early therapy in the first days of life...
  44. doi request reprint Oseltamivir use in low-birth weight infants during the 2009 nH1N1 influenza a outbreak in the Western Cape, South Africa
    Sandi L Holgate
    Department of Pediatrics and Child Health, Tygerberg Children s Hospital and Stellenbosch University, Cape Town, South Africa
    J Trop Pediatr 58:102-6. 2012
    ..A causal relationship between oseltamivir and NEC, although unlikely, cannot be confirmed or excluded...
  45. ncbi request reprint Pseudocystic cryptococcal meningitis complicated by transient periaqueductal obstruction in a child with HIV infection
    Ronald van Toorn
    Department of Pediatrics and Child Health, Faculty of Health Sciences, Stellenbosch University and Tygerberg Children s Hospital, P O Box 19063, Tygerberg 7505, South Africa
    Eur J Paediatr Neurol 9:81-4. 2005
    ..The neuroradiological features of this case are presented and we also postulate on the pathogenesis of the type of hydrocephalus encountered...
  46. ncbi request reprint Cohort profile: the paediatric antiretroviral treatment programmes in lower-income countries (KIDS-ART-LINC) collaboration
    Elise Arrive
    Unité INSERM 593, Institut de Santé Publique, Epidémiologie et Développement ISPED, Universite Victor Segalen, Bordeaux, France
    Int J Epidemiol 37:474-80. 2008
  47. pmc Effect of isoniazid prophylaxis on mortality and incidence of tuberculosis in children with HIV: randomised controlled trial
    Heather J Zar
    School of Child and Adolescent Health, Red Cross Children s Hospital, University of Cape Town, South Africa
    BMJ 334:136. 2007
    ..To investigate the impact of isoniazid prophylaxis on mortality and incidence of tuberculosis in children with HIV...