Mpiko Ntsekhe

Summary

Affiliation: University of Cape Town
Country: South Africa

Publications

  1. doi request reprint Recent advances in the epidemiology, outcome, and prevention of myocardial infarction and stroke in sub-Saharan Africa
    Mpiko Ntsekhe
    Department of Medicine, The Cardiac Clinic, Groote Schuur Hospital and University of Cape Town, Cape Town, South Africa
    Heart 99:1230-5. 2013
  2. doi request reprint Tuberculous pericarditis with and without HIV
    Mpiko Ntsekhe
    The Cardiac Clinic, Department of Medicine, Groote Schuur Hospital and University of Cape Town, E 17 New Groote Schuur Hospital, Observatory 7925, Cape Town, South Africa
    Heart Fail Rev 18:367-73. 2013
  3. pmc The prevalence and outcome of effusive constrictive pericarditis: a systematic review of the literature
    Mpiko Ntsekhe
    Cardiac Clinic, Department of Medicine, Groote Schuur Hospital and University of Cape Town, Cape Town, South Africa
    Cardiovasc J Afr 23:281-5. 2012
  4. doi request reprint Cardiac manifestations of HIV infection: an African perspective
    Mpiko Ntsekhe
    Division of Cardiology at Groote Schuur Hospital, Cape Town, South Africa
    Nat Clin Pract Cardiovasc Med 6:120-7. 2009
  5. pmc The diagnostic accuracy of pericardial and urinary lipoarabinomannan (LAM) assays in patients with suspected tuberculous pericarditis
    Shaheen Pandie
    The Cardiac Clinic, Department of Medicine, Groote Schuur Hospital and University of Cape Town, Cape Town, South Africa
    Sci Rep 6:32924. 2016
  6. pmc Prevalence, hemodynamics, and cytokine profile of effusive-constrictive pericarditis in patients with tuberculous pericardial effusion
    Mpiko Ntsekhe
    Department of Medicine, Groote Schuur Hospital and University of Cape Town, Cape Town, Western Cape, South Africa
    PLoS ONE 8:e77532. 2013
  7. pmc HIV infection is associated with a lower incidence of constriction in presumed tuberculous pericarditis: a prospective observational study
    Mpiko Ntsekhe
    Department of Medicine, University of Cape Town, Cape Town, South Africa
    PLoS ONE 3:e2253. 2008
  8. pmc Quantification of echodensities in tuberculous pericardial effusion using fractal geometry: a proof of concept study
    Mpiko Ntsekhe
    Department of Medicine, The Cardiac Clinic, Groote Schuur Hospital and University of Cape Town, Anzio Road, Observatory 7925, Cape Town, South Africa
    Cardiovasc Ultrasound 10:30. 2012
  9. doi request reprint Rationale and design of the Investigation of the Management of Pericarditis (IMPI) trial: a 2 × 2 factorial randomized double-blind multicenter trial of adjunctive prednisolone and Mycobacterium w immunotherapy in tuberculous pericarditis
    Bongani M Mayosi
    The Cardiac Clinic, Department of Medicine, Groote Schuur Hospital, Cape Town, South Africa
    Am Heart J 165:109-15.e3. 2013
  10. pmc Heart failure and cardiogenic shock associated with the TB-immune reconstitution inflammatory syndrome
    Chris Kenyon
    Department of Medicine, GF Jooste Hospital, Cape Town, South Africa
    Cardiovasc J Afr 23:e14-7. 2012

Detail Information

Publications17

  1. doi request reprint Recent advances in the epidemiology, outcome, and prevention of myocardial infarction and stroke in sub-Saharan Africa
    Mpiko Ntsekhe
    Department of Medicine, The Cardiac Clinic, Groote Schuur Hospital and University of Cape Town, Cape Town, South Africa
    Heart 99:1230-5. 2013
    ..A concerted effort to understand the primary drivers of this increase in cardiac risk factors is required to prevent a future epidemic of atherosclerosis and its sequelae. ..
  2. doi request reprint Tuberculous pericarditis with and without HIV
    Mpiko Ntsekhe
    The Cardiac Clinic, Department of Medicine, Groote Schuur Hospital and University of Cape Town, E 17 New Groote Schuur Hospital, Observatory 7925, Cape Town, South Africa
    Heart Fail Rev 18:367-73. 2013
    ....
  3. pmc The prevalence and outcome of effusive constrictive pericarditis: a systematic review of the literature
    Mpiko Ntsekhe
    Cardiac Clinic, Department of Medicine, Groote Schuur Hospital and University of Cape Town, Cape Town, South Africa
    Cardiovasc J Afr 23:281-5. 2012
    ..Appropriate studies are needed to determine the epidemiology of ECP in tuberculous pericarditis, which is one of the leading causes of pericardial disease in the world...
  4. doi request reprint Cardiac manifestations of HIV infection: an African perspective
    Mpiko Ntsekhe
    Division of Cardiology at Groote Schuur Hospital, Cape Town, South Africa
    Nat Clin Pract Cardiovasc Med 6:120-7. 2009
    ..Herein, we review the cardiac manifestations of HIV in sub-Saharan Africa...
  5. pmc The diagnostic accuracy of pericardial and urinary lipoarabinomannan (LAM) assays in patients with suspected tuberculous pericarditis
    Shaheen Pandie
    The Cardiac Clinic, Department of Medicine, Groote Schuur Hospital and University of Cape Town, Cape Town, South Africa
    Sci Rep 6:32924. 2016
    ..5% versus 19.7%; p < 0.001). Urinary and PF LAM assays have low sensitivity but high specificity for diagnosis of TBP. The sensitivity of urinary LAM is increased in HIV-infected patients with a CD4 ≤ 100 cells/mm(3). ..
  6. pmc Prevalence, hemodynamics, and cytokine profile of effusive-constrictive pericarditis in patients with tuberculous pericardial effusion
    Mpiko Ntsekhe
    Department of Medicine, Groote Schuur Hospital and University of Cape Town, Cape Town, Western Cape, South Africa
    PLoS ONE 8:e77532. 2013
    ..We conducted a prospective study of prevalence and cytokine profile of effusive-constrictive disease in patients with tuberculous pericardial effusion...
  7. pmc HIV infection is associated with a lower incidence of constriction in presumed tuberculous pericarditis: a prospective observational study
    Mpiko Ntsekhe
    Department of Medicine, University of Cape Town, Cape Town, South Africa
    PLoS ONE 3:e2253. 2008
    ..The impact of human immunodeficiency virus (HIV) infection on the incidence of constrictive pericarditis following tuberculous pericardial effusion is unknown...
  8. pmc Quantification of echodensities in tuberculous pericardial effusion using fractal geometry: a proof of concept study
    Mpiko Ntsekhe
    Department of Medicine, The Cardiac Clinic, Groote Schuur Hospital and University of Cape Town, Anzio Road, Observatory 7925, Cape Town, South Africa
    Cardiovasc Ultrasound 10:30. 2012
    ....
  9. doi request reprint Rationale and design of the Investigation of the Management of Pericarditis (IMPI) trial: a 2 × 2 factorial randomized double-blind multicenter trial of adjunctive prednisolone and Mycobacterium w immunotherapy in tuberculous pericarditis
    Bongani M Mayosi
    The Cardiac Clinic, Department of Medicine, Groote Schuur Hospital, Cape Town, South Africa
    Am Heart J 165:109-15.e3. 2013
    ..w) can safely reduce mortality and morbidity...
  10. pmc Heart failure and cardiogenic shock associated with the TB-immune reconstitution inflammatory syndrome
    Chris Kenyon
    Department of Medicine, GF Jooste Hospital, Cape Town, South Africa
    Cardiovasc J Afr 23:e14-7. 2012
    ..Possible aetiologies and pathophysiology as well as suggested diagnostic and therapeutic approaches to this problem are discussed...
  11. pmc Clinical characteristics and initial management of patients with tuberculous pericarditis in the HIV era: the Investigation of the Management of Pericarditis in Africa (IMPI Africa) registry
    Bongani M Mayosi
    The Cardiac Clinic, Department of Medicine, University of Cape Town, E25 Groote Schuur Hospital, Observatory 7925, South Africa
    BMC Infect Dis 6:2. 2006
    ....
  12. pmc Contribution of the human immunodeficiency virus/acquired immunodeficiency syndrome epidemic to de novo presentations of heart disease in the Heart of Soweto Study cohort
    Karen Sliwa
    Faculty of Health Sciences, Hatter Institute for Cardiovascular Research in Africa and IIDMM, University of Cape Town, Cape Town, South Africa
    Eur Heart J 33:866-74. 2012
    ..The Heart of Soweto Study provides a unique opportunity to identify the contribution of cardiac manifestations of this epidemic to de novo presentations of heart disease in an urban African community in epidemiological transition...
  13. ncbi request reprint Impact of human immunodeficiency virus infection on cardiovascular disease in Africa
    Mpiko Ntsekhe
    The Cardiac Clinic, Department of Medicine, Groote Schuur Hospital, University of Cape Town, Cape Town, South Africa
    Circulation 112:3602-7. 2005
    ..Human immunodeficiency virus (HIV) infection is the single greatest health challenge facing Africa today. However, the impact of the HIV epidemic on the cardiovascular system in Africans has received scant attention in the world literature...
  14. pmc Cardio-Thoracic Ratio Is Stable, Reproducible and Has Potential as a Screening Tool for HIV-1 Related Cardiac Disorders in Resource Poor Settings
    Hanif Esmail
    Institute of Infectious Diseases and Molecular Medicine, Clinical Infectious Disease Research Initiative, University of Cape Town, Cape Town, South Africa
    PLoS ONE 11:e0163490. 2016
    ..We further evaluated the prevalence of cardiomegaly (CTR≥0.5) and its relationship with other risk factors in this population...
  15. pmc Diagnostic accuracy of quantitative PCR (Xpert MTB/RIF) for tuberculous pericarditis compared to adenosine deaminase and unstimulated interferon-γ in a high burden setting: a prospective study
    Shaheen Pandie
    The Cardiac Clinic, Department of Medicine, Groote Schuur Hospital and University of Cape Town, Groote Schuur Drive, Observatory, Cape Town 7925, South Africa
    BMC Med 12:101. 2014
    ..This study sought to evaluate the diagnostic accuracy of the Xpert MTB/RIF test compared to pericardial adenosine deaminase (ADA) and unstimulated interferon-gamma (uIFNγ) in suspected TBP...
  16. pmc Predominance of interleukin-22 over interleukin-17 at the site of disease in human tuberculosis
    Kerryn Matthews
    Clinical Infectious Diseases Research Initiative, Institute of Infectious Diseases and Molecular Medicine, University of Cape Town, Observatory 7925, South Africa
    Tuberculosis (Edinb) 91:587-93. 2011
    ..We propose that our findings support a role for IL-22 in TB-induced pathology or the resulting repair process...
  17. doi request reprint Concomitant renal and iliac fibromuscular dysplasia
    Ashley Chin
    Cardiac Clinic, Groote Schuur Hospital, University of Cape Town, South Africa
    Catheter Cardiovasc Interv 73:519-20. 2009
    ..We report an unusual case of FMD in a middle-aged woman, not only involving both the renal and iliac arteries but also presenting in a pattern more typical of atherosclerosis...