Bongani M Mayosi

Summary

Affiliation: University of Cape Town
Country: South Africa

Publications

  1. pmc Clinical characteristics and initial management of patients with tuberculous pericarditis in the HIV era: the Investigation of the Management of Pericarditis in Africa (IMPI Africa) registry
    Bongani M Mayosi
    The Cardiac Clinic, Department of Medicine, University of Cape Town, E25 Groote Schuur Hospital, Observatory 7925, South Africa
    BMC Infect Dis 6:2. 2006
  2. ncbi Measured haplotype analysis of the aldosterone synthase gene and heart size
    Bongani M Mayosi
    Department of Cardiovascular Medicine, University of Oxford, The Wellcome Trust Centre for Human Genetics, Oxford, UK
    Eur J Hum Genet 11:395-401. 2003
  3. ncbi Genotype at the -174G/C polymorphism of the interleukin-6 gene is associated with common carotid artery intimal-medial thickness: family study and meta-analysis
    Bongani M Mayosi
    Department of Cardiovascular Medicine, University of Oxford, Oxford, United Kingdom
    Stroke 36:2215-9. 2005
  4. pmc Contemporary trends in the epidemiology and management of cardiomyopathy and pericarditis in sub-Saharan Africa
    Bongani M Mayosi
    Department of Medicine, J Floor Old Main Building, Groote Schuur Hospital, Observatory 7925, Cape Town, South Africa
    Heart 93:1176-83. 2007
  5. ncbi Interventions for treating tuberculous pericarditis
    B M Mayosi
    The Cardiac Clinic, E25 Groote Schuur Hospital, Observatory 7925, Cape Town, South Africa
    Cochrane Database Syst Rev . 2002
  6. ncbi Protocols for antibiotic use in primary and secondary prevention of rheumatic fever
    Bongani M Mayosi
    Department of Medicine, Groote Schuur Hospital and University of Cape Town, South Africa
    S Afr Med J 96:240. 2006
  7. ncbi Tuberculous pericarditis
    Bongani M Mayosi
    The Cardiac Clinic, Department of Medicine, University of Cape Town, Groote Schuur Hospital, Cape Town, South Africa
    Circulation 112:3608-16. 2005
  8. ncbi Mortality in patients treated for tuberculous pericarditis in sub-Saharan Africa
    Bongani M Mayosi
    Department of Medicine, University of Cape Town
    S Afr Med J 98:36-40. 2008
  9. pmc Prevalence, hemodynamics, and cytokine profile of effusive-constrictive pericarditis in patients with tuberculous pericardial effusion
    Mpiko Ntsekhe
    Department of Medicine, Groote Schuur Hospital and University of Cape Town, Cape Town, Western Cape, South Africa
    PLoS ONE 8:e77532. 2013
  10. doi Achieving the health Millennium Development Goals for South Africa: challenges and priorities
    Mickey Chopra
    Health Systems Research Unit, Medical Research Council, Cape Town, South Africa
    Lancet 374:1023-31. 2009

Detail Information

Publications91

  1. pmc Clinical characteristics and initial management of patients with tuberculous pericarditis in the HIV era: the Investigation of the Management of Pericarditis in Africa (IMPI Africa) registry
    Bongani M Mayosi
    The Cardiac Clinic, Department of Medicine, University of Cape Town, E25 Groote Schuur Hospital, Observatory 7925, South Africa
    BMC Infect Dis 6:2. 2006
    ....
  2. ncbi Measured haplotype analysis of the aldosterone synthase gene and heart size
    Bongani M Mayosi
    Department of Cardiovascular Medicine, University of Oxford, The Wellcome Trust Centre for Human Genetics, Oxford, UK
    Eur J Hum Genet 11:395-401. 2003
    ..These results point to the importance of analysing the full extent of genetic variation that captures the haplotype structure of a locus in gene association studies...
  3. ncbi Genotype at the -174G/C polymorphism of the interleukin-6 gene is associated with common carotid artery intimal-medial thickness: family study and meta-analysis
    Bongani M Mayosi
    Department of Cardiovascular Medicine, University of Oxford, Oxford, United Kingdom
    Stroke 36:2215-9. 2005
    ..We have used a family-based genetic association design to assess the heritability of carotid IMT and to investigate the hypothesized association of carotid IMT with the IL-6 to -174G/C polymorphism...
  4. pmc Contemporary trends in the epidemiology and management of cardiomyopathy and pericarditis in sub-Saharan Africa
    Bongani M Mayosi
    Department of Medicine, J Floor Old Main Building, Groote Schuur Hospital, Observatory 7925, Cape Town, South Africa
    Heart 93:1176-83. 2007
    ....
  5. ncbi Interventions for treating tuberculous pericarditis
    B M Mayosi
    The Cardiac Clinic, E25 Groote Schuur Hospital, Observatory 7925, Cape Town, South Africa
    Cochrane Database Syst Rev . 2002
    ..Tuberculous pericarditis - tuberculosis infection of the pericardial membrane (pericardium) covering the heart - is becoming more common. The infection can result in fluid around the heart or fibrosis of the pericardium, which can be fatal...
  6. ncbi Protocols for antibiotic use in primary and secondary prevention of rheumatic fever
    Bongani M Mayosi
    Department of Medicine, Groote Schuur Hospital and University of Cape Town, South Africa
    S Afr Med J 96:240. 2006
  7. ncbi Tuberculous pericarditis
    Bongani M Mayosi
    The Cardiac Clinic, Department of Medicine, University of Cape Town, Groote Schuur Hospital, Cape Town, South Africa
    Circulation 112:3608-16. 2005
    ..The primary objective of this article was to review and summarize the literature on the pathogenesis, diagnosis, and management of tuberculous pericarditis...
  8. ncbi Mortality in patients treated for tuberculous pericarditis in sub-Saharan Africa
    Bongani M Mayosi
    Department of Medicine, University of Cape Town
    S Afr Med J 98:36-40. 2008
    ..To determine the mortality rate and its predictors in patients with a presumptive diagnosis of tuberculous pericarditis in sub-Saharan Africa...
  9. pmc Prevalence, hemodynamics, and cytokine profile of effusive-constrictive pericarditis in patients with tuberculous pericardial effusion
    Mpiko Ntsekhe
    Department of Medicine, Groote Schuur Hospital and University of Cape Town, Cape Town, Western Cape, South Africa
    PLoS ONE 8:e77532. 2013
    ..We conducted a prospective study of prevalence and cytokine profile of effusive-constrictive disease in patients with tuberculous pericardial effusion...
  10. doi Achieving the health Millennium Development Goals for South Africa: challenges and priorities
    Mickey Chopra
    Health Systems Research Unit, Medical Research Council, Cape Town, South Africa
    Lancet 374:1023-31. 2009
    ..The South African Government, installed in April, 2009, has the mandate and potential to address the public health emergencies facing the country--will they do so or will another opportunity and many more lives be lost?..
  11. doi Health in South Africa: changes and challenges since 2009
    Bongani M Mayosi
    Department of Medicine, Groote Schuur Hospital, Cape Town, South Africa
    Lancet 380:2029-43. 2012
    ....
  12. doi A cost-effective strategy for primary prevention of acute rheumatic fever and rheumatic heart disease in children with pharyngitis
    James H Irlam
    Primary Health Care Directorate, University of Cape Town, South Africa
    S Afr Med J 103:894-5. 2013
    ..The CDR2+ strategy is the most cost-effective for primary prevention of ARF and RHD in urban SA and should complement primordial and secondary prevention efforts. ..
  13. doi Beta-blockers for hypertension
    Charles Shey Wiysonge
    Division of Medical Microbiology and Institute of Infectious Disease andMolecular Medicine, University of Cape Town, Observatory, South Africa
    Cochrane Database Syst Rev 11:CD002003. 2012
    ..This review is an update of the Cochrane Review published in 2007, which assessed the role of beta-blockade as first-line therapy for hypertension...
  14. pmc HIV-1 infection alters CD4+ memory T-cell phenotype at the site of disease in extrapulmonary tuberculosis
    Kerryn Matthews
    Clinical Infectious Diseases Research Initiative, Institute of Infectious Diseases and Molecular Medicine, University of Cape Town, Observatory, South Africa
    Eur J Immunol 42:147-57. 2012
    ..These results indicate that HIV-1 infection results in altered phenotype and function of MTB-specific CD4+ T cells at the disease site, which may contribute to the increased risk of developing TB at all stages of HIV-1 infection...
  15. pmc Motion-guided segmentation for cine DENSE MRI
    Bruce S Spottiswoode
    UCT MRC Medical Imaging Research Unit, University of Cape Town, South Africa
    Med Image Anal 13:105-15. 2009
    ..Motion-guided segmentation employs the displacement-encoded phase shifts intrinsic to DENSE MRI to accurately propagate a single set of pre-defined contours throughout the remaining cardiac phases...
  16. pmc Genetic variation at selected SNPs in the leptin gene and association of alleles with markers of kidney disease in a Xhosa population of South Africa
    Ikechi G Okpechi
    Department of Medicine, Groote Schuur Hospital and University of Cape Town, Cape Town, South Africa
    PLoS ONE 5:e9086. 2010
    ..A number of clinical and experimental studies have suggested a link between serum leptin and kidney disease. We hypothesised that variants in the leptin gene (LEP) may be associated with markers of CKD in indigenous black Africans...
  17. pmc The diagnostic accuracy of pericardial and urinary lipoarabinomannan (LAM) assays in patients with suspected tuberculous pericarditis
    Shaheen Pandie
    The Cardiac Clinic, Department of Medicine, Groote Schuur Hospital and University of Cape Town, Cape Town, South Africa
    Sci Rep 6:32924. 2016
    ..5% versus 19.7%; p < 0.001). Urinary and PF LAM assays have low sensitivity but high specificity for diagnosis of TBP. The sensitivity of urinary LAM is increased in HIV-infected patients with a CD4 ≤ 100 cells/mm(3). ..
  18. doi Clinical features, survival experience, and profile of plakophylin-2 gene mutations in participants of the arrhythmogenic right ventricular cardiomyopathy registry of South Africa
    David A Watkins
    Cardiovascular Genetics Laboratory, Hatter Institute for Cardiovascular Research, Department of Medicine, Groote Schuur Hospital and University of Cape Town, Cape Town, South Africa
    Heart Rhythm 6:S10-7. 2009
    ..PKP2 gene mutations are common, have an allele dose effect, and a novel founder effect in white South Africans...
  19. doi Cardiac manifestations of HIV infection: an African perspective
    Mpiko Ntsekhe
    Division of Cardiology at Groote Schuur Hospital, Cape Town, South Africa
    Nat Clin Pract Cardiovasc Med 6:120-7. 2009
    ..Herein, we review the cardiac manifestations of HIV in sub-Saharan Africa...
  20. ncbi Clinical Outcomes in 3343 Children and Adults With Rheumatic Heart Disease From 14 Low- and Middle-Income Countries: Two-Year Follow-Up of the Global Rheumatic Heart Disease Registry (the REMEDY Study)
    Liesl Zuhlke
    From Cardiac Clinic, Department of Medicine, Groote Schuur Hospital and University of Cape Town, South Africa L Z, M E E, B C, R D, V F, B M M Division of Paediatric Cardiology, Department of Paediatrics and Child Health, Red Cross War Memorial Children s Hospital and University of Cape Town, South Africa L Z, C H H Department of Cardiology, All India Institute of Medical Sciences, New Delhi G K Population Health Research Institute, Hamilton Health Sciences and McMaster University, Ontario, Canada S R, P M, S I, K T, S Y Department of Statistical Sciences, University of Cape Town, South Africa K M Department of Surgery, School of Medicine, College of Health Sciences, University of Nairobi, Kenya S O Cardiology Unit, Department of Medicine, Kenyatta National Teaching and Referral Hospital, Nairobi, Kenya B G Cardiology Unit, Department of Medicine, Mulago Hospital, Kampala, Uganda C M Uganda Heart Institute, Kampala E O, P L Faculty of Medicine and Surgery, Department of Pediatrics
    Circulation 134:1456-1466. 2016
    ..We report the 2-year follow-up of individuals with rheumatic heart disease from 14 low- and middle-income countries in Africa and Asia...
  21. doi Primary prevention of acute rheumatic fever and rheumatic heart disease with penicillin in South African children with pharyngitis: a cost-effectiveness analysis
    James Irlam
    Primary Health Care Directorate, Faculty of Health Sciences, University of Cape Town, Cape Town, South Africa
    Circ Cardiovasc Qual Outcomes 6:343-51. 2013
    ..We describe a cost-effective analysis of 7 strategies for the primary prevention of acute rheumatic fever and rheumatic heart disease in children presenting with pharyngitis in urban primary care clinics in South Africa...
  22. doi Rationale and design of the Investigation of the Management of Pericarditis (IMPI) trial: a 2 × 2 factorial randomized double-blind multicenter trial of adjunctive prednisolone and Mycobacterium w immunotherapy in tuberculous pericarditis
    Bongani M Mayosi
    The Cardiac Clinic, Department of Medicine, Groote Schuur Hospital, Cape Town, South Africa
    Am Heart J 165:109-15.e3. 2013
    ..w) can safely reduce mortality and morbidity...
  23. doi Genome-wide linkage analysis of electrocardiographic and echocardiographic left ventricular hypertrophy in families with hypertension
    Bongani M Mayosi
    Department of Medicine, University of Cape Town, J Floor Old Main Building, Groote Schuur Hospital, Anzio Road Observatory, Cape Town 7925, W Cape, South Africa
    Eur Heart J 29:525-30. 2008
    ..To localize chromosomal regions (or quantitative trait loci) that harbour genetic variants influencing the variability of electrocardiographic (ECG) and echocardiographic left ventricular hypertrophy (LVH)...
  24. pmc Rationale and design of the African group A streptococcal infection registry: the AFROStrep study
    Dylan D Barth
    Department of Medicine, Faculty of Health Sciences, University of Cape Town and Groote Schuur Hospital, Cape Town, South Africa
    BMJ Open 6:e010248. 2016
    ..Invasive GAS (iGAS) disease is an important cause of mortality and morbidity worldwide. The burden of GAS infections is, however, unknown in Africa because of lack of surveillance systems...
  25. doi Bi treatment with hydralazine/nitrates vs. placebo in Africans admitted with acute HEart Failure (BA-HEF)
    Karen Sliwa
    Hatter Institute for Cardiovascular Research in Africa and IDM, Inter Cape Heart Group South African Medical Research Council, Department of Medicine, Faculty of Health Sciences, University of Cape Town, South Africa
    Eur J Heart Fail 18:1248-1258. 2016
    ..Patients with acute heart failure (HF) in Africa are rarely being treated with a hydralazine/nitrates combination. Therefore the effect of this treatment was studied here...
  26. pmc The mitochondrial DNA T16189C polymorphism and HIV-associated cardiomyopathy: a genotype-phenotype association study
    Gasnat Shaboodien
    Department of Clinical Neurology, University of Oxford, The West Wing, The John Radcliffe Hospital, Oxford, OX3 9DU, UK
    BMC Med Genet 10:37. 2009
    ..We hypothesized that this variant may predispose to dilated cardiomyopathy in people who are infected with the human immunodeficiency virus (HIV)...
  27. pmc HIV infection is associated with a lower incidence of constriction in presumed tuberculous pericarditis: a prospective observational study
    Mpiko Ntsekhe
    Department of Medicine, University of Cape Town, Cape Town, South Africa
    PLoS ONE 3:e2253. 2008
    ..The impact of human immunodeficiency virus (HIV) infection on the incidence of constrictive pericarditis following tuberculous pericardial effusion is unknown...
  28. ncbi A modern approach to tuberculous pericarditis
    Faisal F Syed
    Department of Medicine, Groote Schuur Hospital and University of Cape Town, Cape Town, South Africa
    Prog Cardiovasc Dis 50:218-36. 2007
    ....
  29. ncbi Clinical characteristics and outcomes of familial and idiopathic dilated cardiomyopathy in Cape Town: a comparative study of 120 cases followed up over 14 years
    Ntobeko B A Ntusi
    Cardiac Clinic, Department of Medicine, Groote Schuur Hospital, University of Cape Town
    S Afr Med J 101:399-404. 2011
    ..It is not known whether there are differences in clinical characteristics and outcomes of patients with familial and idiopathic dilated cardiomyopathy (DCM) in an African setting...
  30. pmc The natural history of latent rheumatic heart disease in a 5 year follow-up study: a prospective observational study
    Liesl Zuhlke
    The Cardiac Clinic, Department of Medicine, Groote Schuur Hospital and University of Cape Town, Cape Town, South Africa
    BMC Cardiovasc Disord 16:46. 2016
    ..The natural history of latent RHD is unclear but has important clinical and economic implications about whether these children should receive penicillin prophylaxis or not. We performed a 5-year prospective study of this question...
  31. doi Prognostic significance of ECG abnormalities for mortality risk in acute heart failure: insight from the Sub-Saharan Africa Survey of Heart Failure (THESUS-HF)
    Anastase Dzudie
    DOUALA General Hospital, Douala, and Buea Faculty of Health Sciences, Buea, Cameroon Department of Medicine, Faculty of Health Sciences, University of Cape Town, Cape Town, South Africa
    J Card Fail 20:45-52. 2014
    ..The aim of this study was to assess the predictive utility of 12-lead electrocardiogram (ECG) abnormalities among Africans with acute heart failure (HF)...
  32. doi Readmission and death after an acute heart failure event: predictors and outcomes in sub-Saharan Africa: results from the THESUS-HF registry
    Karen Sliwa
    Department of Medicine, Faculty of Health Sciences, Hatter Institute for Cardiovascular Research in Africa and the Institute of Infectious Disease and Molecular Medicine, University of Cape Town, Cape Town, South Africa
    Eur Heart J 34:3151-9. 2013
    ..We sought to describe factors prognostic of re-admission and death in this developing population...
  33. doi Tuberculous pericarditis with and without HIV
    Mpiko Ntsekhe
    The Cardiac Clinic, Department of Medicine, Groote Schuur Hospital and University of Cape Town, E 17 New Groote Schuur Hospital, Observatory 7925, Cape Town, South Africa
    Heart Fail Rev 18:367-73. 2013
    ....
  34. pmc The prevalence and outcome of effusive constrictive pericarditis: a systematic review of the literature
    Mpiko Ntsekhe
    Cardiac Clinic, Department of Medicine, Groote Schuur Hospital and University of Cape Town, Cape Town, South Africa
    Cardiovasc J Afr 23:281-5. 2012
    ..Appropriate studies are needed to determine the epidemiology of ECP in tuberculous pericarditis, which is one of the leading causes of pericardial disease in the world...
  35. ncbi Frequency and clinical genetics of familial dilated cardiomyopathy in Cape Town: implications for the evaluation of patients with unexplained cardiomyopathy
    Ntobeko B A Ntusi
    Cardiac Clinic and Cardiovascular Genetics Laboratory, Hatter Institute for Cardiovascular Research in Africa, Department of Medicine, Groote Schuur Hospital, University of Cape Town
    S Afr Med J 101:394-8. 2011
    ..Studies from Europe and North America suggest that 20 - 50% of patients with dilated cardiomyopathy (DCM) may have familial disease. There is little information on the frequency and clinical genetics of familial DCM in Africa...
  36. pmc Beta-blockers for hypertension
    Charles S Wiysonge
    Cochrane South Africa, South African Medical Research Council, Francie van Zijl Drive, Parow Valley, Cape Town, Western Cape, South Africa, 7505
    Cochrane Database Syst Rev 1:CD002003. 2017
    ..However, the benefit of beta-blockers as first-line therapy for hypertension without compelling indications is controversial. This review is an update of a Cochrane Review initially published in 2007 and updated in 2012...
  37. pmc Seven key actions to eradicate rheumatic heart disease in Africa: the Addis Ababa communiqué
    David Watkins
    Department of Medicine, Groote Schuur Hospital and University of Cape Town, South Africa University of Washington, USA
    Cardiovasc J Afr 27:184-187. 2016
    ..This Addis Ababa communiqué has since been endorsed by African Union heads of state, and plans are underway to implement the roadmap in order to end ARF and RHD in Africa in our lifetime...
  38. pmc Pregnancy-Associated Heart Failure: A Comparison of Clinical Presentation and Outcome between Hypertensive Heart Failure of Pregnancy and Idiopathic Peripartum Cardiomyopathy
    Ntobeko B A Ntusi
    The Cardiac Clinic, Department of Medicine, Groote Schuur Hospital and University of Cape Town, Cape Town, South Africa
    PLoS ONE 10:e0133466. 2015
    ..We sought to determine whether hypertensive heart failure of pregnancy (HHFP) (i.e., peripartum cardiac failure associated with any form of hypertension) and PPCM have similar or different clinical features and outcome...
  39. pmc Quantification of echodensities in tuberculous pericardial effusion using fractal geometry: a proof of concept study
    Mpiko Ntsekhe
    Department of Medicine, The Cardiac Clinic, Groote Schuur Hospital and University of Cape Town, Anzio Road, Observatory 7925, Cape Town, South Africa
    Cardiovasc Ultrasound 10:30. 2012
    ....
  40. pmc The burden of antenatal heart disease in South Africa: a systematic review
    David A Watkins
    Department of Medicine, Groote Schuur Hospital and University of Cape Town, J Floor Old Main Building, Groote Schuur Hospital, Observatory, Cape Town 7925, South Africa
    BMC Cardiovasc Disord 12:23. 2012
    ..Maternal mortality in South Africa is rising, and heart conditions currently account for 41 per cent of indirect causes of deaths. Little is known about the burden of heart disease in pregnant South Africans...
  41. pmc Antibiotics for the primary prevention of acute rheumatic fever: a meta-analysis
    Katharine A Robertson
    Faculty of Health Sciences, University of Cape Town, Cape Town, South Africa
    BMC Cardiovasc Disord 5:11. 2005
    ....
  42. doi Evaluation of a focussed protocol for hand-held echocardiography and computer-assisted auscultation in detecting latent rheumatic heart disease in scholars
    Liesl J Zühlke
    1Department of Medicine, The Cardiac Clinic, Groote Schuur Hospital and University of Cape Town, Cape Town, South Africa
    Cardiol Young 26:1097-106. 2016
    ..We evaluated the performance of a brief hand-held echocardiography protocol and computer-assisted auscultation in detecting latent rheumatic heart disease with or without pathological murmur...
  43. pmc Clinical features, spectrum of causal genetic mutations and outcome of hypertrophic cardiomyopathy in South Africans
    Ntobeko A Ntusi
    Cardiovascular Genetics Laboratory, Hatter Institute for Cardiovascular Research in Africa and The Cardiac Clinic, Department of Medicine, Groote Schuur Hospital and University of Cape Town, Cape Town, South Africa Email ntobeko ntusi gmail com
    Cardiovasc J Afr 27:152-158. 2016
    ..The objective of this study was to delineate the clinical and genetic features and outcome of HCM in African patients...
  44. pmc Poor Penetration of Antibiotics Into Pericardium in Pericardial Tuberculosis
    Justin Shenje
    Divisions of Cardiology, Groote Schuur Hospital, University of Cape Town, Observatory, South Africa
    EBioMedicine 2:1640-9. 2015
    ..Pericardial concentrations of the key sterilizing drugs for TB were below MIC, which could contribute to poor outcomes. A new regimen that overcomes these limitations might need to be crafted...
  45. ncbi Mycobacterium w Immunotherapy for Treating Pulmonary Tuberculosis - a Systematic Review
    Shaheen Pandie
    Department of Medicine, Old Groote Schuur Hospital, Observatory 7925, Cape Town, South Africa
    Curr Pharm Des 20:6207-14. 2014
    ..Mycobacterium w is a heat-killed immune-modulating vaccine designed to attenuate the effects of TB, reduce time to sputum conversion, and thereby decrease transmission and improve cure rates...
  46. doi Recent advances in the epidemiology, pathogenesis and prognosis of acute heart failure and cardiomyopathy in Africa
    Karen Sliwa
    Hatter Institute for Cardiovascular Research in Africa, Department of Medicine, Groote Schuur Hospital and University of Cape Town, Cape Town, South Africa
    Heart 99:1317-22. 2013
    ..The key challenges of management of heart failure are the urgent need to increase the use of proven treatments by physicians, and the control of hypertension in primary care and at the population level...
  47. pmc Genetic susceptibility to acute rheumatic fever: a systematic review and meta-analysis of twin studies
    Mark E Engel
    Department of Medicine, Groote Schuur Hospital and University of Cape Town, Cape Town, South Africa
    PLoS ONE 6:e25326. 2011
    ..The objective of this study was to conduct a systematic review and meta-analysis of twin studies of concordance of acute rheumatic fever in order to derive quantitative estimates of the size of the genetic effect...
  48. pmc Cardiomyopathy in Africa: heredity versus environment
    Bongani M Mayosi
    Department of Medicine, University of Cape Town, Groote Schuur Hospital, Cape Town
    Cardiovasc J Afr 18:175-9. 2007
    ..There is a need for renewed effort to identify genetic and non-genetic factors in EMF and other forms of heart muscle disease that are prevalent on the continent of Africa...
  49. doi Epidemiology of heart failure in sub-Saharan Africa
    Ntobeko B A Ntusi
    Department of Medicine, Groote Schuur Hospital and University of Cape Town, Cape Town, South Africa
    Expert Rev Cardiovasc Ther 7:169-80. 2009
    ....
  50. ncbi Lack of adherence to the national guidelines on the prevention of rheumatic fever
    Katharine A Robertson
    Cardiac Clinic, Department of Medicine, Groote Schuur Hospital and University of Cape Town
    S Afr Med J 95:52-6. 2005
    ....
  51. doi Endemic Cardiovascular Diseases of the Poorest Billion
    Gene F Kwan
    From Department of Medicine, Boston University School of Medicine, MA G F K Department of Global Health and Social Medicine, Harvard Medical School, Boston, MA G F K, G B Partners In Health, Boston, MA G F K, G B Department of Medicine, Groote Schuur Hospital and University of Cape Town, South Africa B M M Universidade Eduardo Mondlane and the Instituto Nacional de Saúde, Maputo, Mozambique A O M Department of Medicine, School of Medicine Universidad Peruana Cayetano Heredia, Lima, Peru J J M CRONICAS Center of Excellence in Chronic Diseases, Universidad Peruana Cayetano Heredia, Lima, Peru J J M MRC PHE Centre for Environment and Health, and Department of Epidemiology and Biostatistics, School of Public Health, Imperial College London, UK M E Jan Swasthya Sahyog, Village and Post Ganiyari, Bilaspur Chhattisgarh, India Y J Oxford Department of International Development, University of Oxford, UK G R Department of Epidemiology, Boston University School of Public Health, MA E J B Department of Social and Behavioral Sciences, Harvard T H Chan School of Public Health, Boston, MA S V S and Division of Global Health Equity, Brigham and Women s Hospital, Boston, MA G B
    Circulation 133:2561-75. 2016
    ....
  52. pmc Performance of re-used pacemakers and implantable cardioverter defibrillators compared with new devices at Groote Schuur Hospital in Cape Town, South Africa
    Zimasa V Jama
    The Cardiac Clinic, Department of Medicine, Groote Schuur Hospital, Cape Town, South Africa
    Cardiovasc J Afr 26:181-7. 2015
    ..We sought to compare the risk of infection and the rate of malfunction of re-used pacemakers and ICDs with new devices implanted at Groote Schuur Hospital in Cape Town, South Africa...
  53. pmc Prevalence of group A streptococcal disease in North and Sub-Saharan Africa: a systematic review protocol
    Dylan D Barth
    Department of Medicine, Faculty of Health Sciences, University of Cape Town and Groote Schuur Hospital, Cape Town, South Africa
    BMJ Open 5:e008646. 2015
    ..According to Carapetis et al, the prevalence of severe GAS disease is at least 18.1 million cases with an incidence of at least 1.78 million cases per year...
  54. pmc Mutation analysis of the phospholamban gene in 315 South Africans with dilated, hypertrophic, peripartum and arrhythmogenic right ventricular cardiomyopathies
    Maryam Fish
    Cardiovascular Genetics Laboratory, Hatter Institute for Cardiovascular Research in Africa, Department of Medicine, Groote Schuur Hospital and University of Cape Town, Old Groote Schuur Hospital, Groote Schuur Drive, Observatory, 7925, Cape Town, South Africa
    Sci Rep 6:22235. 2016
    ..2%). We conclude that PLN is a rare cause of cardiomyopathy in African patients. The PLN p.R9C mutation is not well-tolerated, emphasising the importance of this gene in cardiac function...
  55. doi Incidence, prevalence and outcome of rheumatic heart disease in South Africa: a systematic review of contemporary studies
    Liesl J Zühlke
    Department of Medicine, Groote Schuur Hospital and University of Cape Town, Cape Town, South Africa Division of Paediatric Cardiology, Department of Paediatrics and Child Health, Red Cross War Memorial Children s Hospital and University of Cape Town, Cape Town, South Africa
    Int J Cardiol 199:375-83. 2015
    ..Twenty years after its first democratic election, South Africa is experiencing a health transition. The impact of change on the incidence, prevalence and outcome of rheumatic heart disease (RHD) is unknown...
  56. pmc Effect of distance to health facility on the maintenance of INR therapeutic ranges in rheumatic heart disease patients from Cape Town: no evidence for an association
    Dylan D Barth
    Department of Medicine, Groote Schuur Hospital and University of Cape Town, J46 43 Old Main Building, Private Bag, 7700, Rondebosch, South Africa
    BMC Health Serv Res 15:219. 2015
    ..This population-based observational study investigated whether the distance between home and an INR clinic affects the maintenance of therapeutic INR in RHD patients on warfarin...
  57. doi Prevalence of rheumatic heart disease in 4720 asymptomatic scholars from South Africa and Ethiopia
    Mark E Engel
    Department of Medicine, Groote Schuur Hospital and University of Cape Town, Cape Town, South Africa
    Heart 101:1389-94. 2015
    ..The use of different diagnostic criteria has led to widely variable estimates of the prevalence of RHD in the same communities...
  58. pmc Increasing the value of health research in the WHO African Region beyond 2015--reflecting on the past, celebrating the present and building the future: a bibliometric analysis
    Olalekan A Uthman
    Centre for Evidence Based Health Care, Faculty of Medicine and Health Sciences, Stellenbosch University, Cape Town, South Africa Warwick Centre for Applied Health Research and Delivery WCAHRD, University of Warwick, Warwick Medical School, Coventry, UK
    BMJ Open 5:e006340. 2015
    ..To assess the profile and determinants of health research productivity in Africa since the onset of the new millennium...
  59. pmc Determinants of PCR performance (Xpert MTB/RIF), including bacterial load and inhibition, for TB diagnosis using specimens from different body compartments
    Grant Theron
    Lung Infection and Immunity Unit, Division of Pulmonology and UCT Lung Institute, Department of Medicine, University of Cape Town, Cape Town, South Africa
    Sci Rep 4:5658. 2014
    ..Mycobacterial load, which displays significant variation across different body compartments, is the main determinant of MTB/RIF-positivity rather than PCR inhibition. MTB/RIF C(T) is a poor surrogate of load in extrapulmonary specimens...
  60. pmc Diagnostic accuracy of quantitative PCR (Xpert MTB/RIF) for tuberculous pericarditis compared to adenosine deaminase and unstimulated interferon-γ in a high burden setting: a prospective study
    Shaheen Pandie
    The Cardiac Clinic, Department of Medicine, Groote Schuur Hospital and University of Cape Town, Groote Schuur Drive, Observatory, Cape Town 7925, South Africa
    BMC Med 12:101. 2014
    ..This study sought to evaluate the diagnostic accuracy of the Xpert MTB/RIF test compared to pericardial adenosine deaminase (ADA) and unstimulated interferon-gamma (uIFNγ) in suspected TBP...
  61. doi Echocardiographic screening for subclinical rheumatic heart disease remains a research tool pending studies of impact on prognosis
    Liesl Zuhlke
    Division of Paediatric Cardiology, Red Cross War Memorial Children s Hospital and University of Cape Town, Cape Town, South Africa
    Curr Cardiol Rep 15:343. 2013
    ..Therefore, echocardiographic screening for asymptomatic subclinical RHD remains a research tool until studies of impact on prognosis and cost-effectiveness are conducted...
  62. doi Beta-blockers for hypertension
    Charles Shey Wiysonge
    Institute of Infectious Disease and Molecular Medicine and Division of Medical Microbiology, University of Cape Town, Anzio Road, Observatory, South Africa, 7925
    Cochrane Database Syst Rev 8:CD002003. 2012
    ..This review is an update of the Cochrane Review published in 2007, which assessed the role of beta-blockade as first-line therapy for hypertension...
  63. pmc Arrhythmogenic right ventricular cardiomyopathy type 6 (ARVC6): support for the locus assignment, narrowing of the critical region and mutation screening of three candidate genes
    Luzuko O Matolweni
    The Cardiac Clinic, Department of Medicine, Groote Schuur Hospital and University of Cape Town, Cape Town, South Africa
    BMC Med Genet 7:29. 2006
    ..By linkage analysis, ARVC type 6 was previously mapped to a 10.6 cM region on chromosome 10p12-p14 in a large North American kindred. To date, the genetic defect that causes ARVC6 has not been identified...
  64. doi Aetiology and risk factors of peripartum cardiomyopathy: a systematic review
    Ntobeko B A Ntusi
    Department of Medicine, Groote Schuur Hospital and University of Cape Town, Cape Town, South Africa
    Int J Cardiol 131:168-79. 2009
    ..The primary objective of this review was to summarize the state of knowledge on the pathogenesis of PPCM, especially in light of recent studies...
  65. doi The burden of non-communicable diseases in South Africa
    Bongani M Mayosi
    Department of Medicine, Groote Schuur Hospital and University of Cape Town, Cape Town, South Africa
    Lancet 374:934-47. 2009
    ....
  66. ncbi Cardiac involvement in HIV-infected people living in Africa: a review
    Nombulelo P Magula
    Infectious Disease Unit, Department of Medicine, Nelson R Mandela School of Medicine, University of Natal, Durban, South Africa
    Cardiovasc J S Afr 14:231-7. 2003
    ....
  67. pmc Characteristics, complications, and gaps in evidence-based interventions in rheumatic heart disease: the Global Rheumatic Heart Disease Registry (the REMEDY study)
    Liesl Zuhlke
    The Cardiac Clinic, Department of Medicine, Groote Schuur Hospital and University of Cape Town, J Floor Old Groote Schuur Hospital, Groote Schuur Drive, Observatory 7925, Cape Town, South Africa Division of Paediatric Cardiology, Department of Paediatrics and Child Health, Red Cross War Memorial Children s Hospital and University of Cape Town, Cape Town, South Africa
    Eur Heart J 36:1115-22a. 2015
    ..Rheumatic heart disease (RHD) accounts for over a million premature deaths annually; however, there is little contemporary information on presentation, complications, and treatment...
  68. pmc The Effects of Angiotensin Converting Enzyme Inhibitors (ACE-I) on Human N-Acetyl-Seryl-Aspartyl-Lysyl-Proline (Ac-SDKP) Levels: A Systematic Review and Meta-Analysis
    Ayanda Trevor Mnguni
    Department of Medicine, University of Cape Town and Groote Schuur Hospital, Cape Town, South Africa
    PLoS ONE 10:e0143338. 2015
    ....
  69. doi Constrictive pericarditis requiring pericardiectomy at Groote Schuur Hospital, Cape Town, South Africa: causes and perioperative outcomes in the HIV era (1990-2012)
    Arthur K Mutyaba
    Department of Medicine, Groote Schuur Hospital and University of Cape Town, Cape Town, South Africa
    J Thorac Cardiovasc Surg 148:3058-65.e1. 2014
    ..We investigated the causes of constrictive pericarditis, outcomes after pericardiectomy, and predictors of mortality in Cape Town, South Africa, during a 22-year period of high HIV/AIDS prevalence...
  70. pmc A cost-effectiveness analysis of a program to control rheumatic fever and rheumatic heart disease in Pinar del Rio, Cuba
    David A Watkins
    Division of General Internal Medicine, Department of Medicine, University of Washington, Seattle, Washington, United States of America Department of Medicine, Groote Schuur Hospital and the University of Cape Town, Cape Town, South Africa
    PLoS ONE 10:e0121363. 2015
    ..In the Pinar del Rio province of Cuba, a comprehensive ARF/RHD control program was undertaken over 1986-1996. The present study analyzes the cost-effectiveness of this Cuban program...
  71. pmc Reference intervals for the echocardiographic measurements of the right heart in children and adolescents: a systematic review
    Carolina E Lemmer Hunsinger
    Department of Medicine, University of Cape Town and Groote Schuur Hospital, Observatory, Cape Town, South Africa
    Cardiovasc Ultrasound 12:3. 2014
    ....
  72. pmc Current status and future prospects of epidemiology and public health training and research in the WHO African region
    Jean B Nachega
    Department of Medicine and Centre for Infectious Diseases, Stellenbosch University, Cape Town, South Africa
    Int J Epidemiol 41:1829-46. 2012
    ..To date little has been published about epidemiology and public health capacity (training, research, funding, human resources) in WHO/AFRO to help guide future planning by various stakeholders...
  73. doi HIV infection, pulmonary arterial hypertension and pregnancy: a fatal triad
    Myat Tun Lin Nyo
    Department of Medicine, Groote Schuur Hospital and University of Cape Town, Cape Town, South Africa
    Cardiovasc J Afr 23:e4-6. 2012
    ..Histological features of pulmonary arterial hypertension were present at post mortem. This is the first report of histologically confirmed HIV-associated pulmonary arterial hypertension associated with pregnancy in Africa...
  74. pmc Predominance of interleukin-22 over interleukin-17 at the site of disease in human tuberculosis
    Kerryn Matthews
    Clinical Infectious Diseases Research Initiative, Institute of Infectious Diseases and Molecular Medicine, University of Cape Town, Observatory 7925, South Africa
    Tuberculosis (Edinb) 91:587-93. 2011
    ..We propose that our findings support a role for IL-22 in TB-induced pathology or the resulting repair process...
  75. doi 3D myocardial tissue tracking with slice followed cine DENSE MRI
    Bruce S Spottiswoode
    UCT MRC Medical Imaging Research Unit, University of Cape Town, South Africa
    J Magn Reson Imaging 27:1019-27. 2008
    ..To track three-dimensional (3D) myocardial tissue motion using slice followed cine displacement encoded imaging with stimulated echoes (DENSE)...
  76. ncbi The C-532T polymorphism of the angiotensinogen gene is associated with pulse pressure: a possible explanation for heterogeneity in genetic association studies of AGT and hypertension
    Michelle Baker
    The Institute of Human Genetics, Newcastle University, UK
    Int J Epidemiol 36:1356-62. 2007
    ..We hypothesized that a primary effect of AGT variants on arterial stiffness (and thus pulse pressure) might explain such heterogeneity, and tested for such an effect in a family study...
  77. ncbi Contemporary use of adjunctive corticosteroids in tuberculous pericarditis
    Charles S Wiysonge
    Int J Cardiol 124:388-90. 2008
    ..These data provide a justification for the establishment of adequately powered randomised clinical trials to assess the effectiveness of adjunctive corticosteroids in patients with tuberculous pericarditis...
  78. ncbi Association between common polymorphisms of the proopiomelanocortin gene and body fat distribution: a family study
    Michelle Baker
    Institute of Human Genetics, Central Parkway, Newcastle NE1 3BZ, UK
    Diabetes 54:2492-6. 2005
    ..These data show that genetic variants at the POMC locus influence body fat distribution within the normal range, suggesting a novel role for POMC in metabolic regulation...
  79. ncbi Genotype at a promoter polymorphism of the interleukin-6 gene is associated with baseline levels of plasma C-reactive protein
    Mark A Vickers
    Department of Medicine and Therapeutics, University of Aberdeen, Aberdeen, UK
    Cardiovasc Res 53:1029-34. 2002
    ..We hypothesised that plasma CRP would be a heritable phenotype that would be influenced by genotype at this polymorphism...
  80. ncbi Molecular genetics of cardiomyopathy: changing times, shifting paradigms
    Johanna C Moolman-Smook
    US MRC for Molecular and Cellular Biology, Faculty of Health Science, University of Stellenbosch, Tygerburg, South Africa
    Cardiovasc J S Afr 14:145-55. 2003
    ....
  81. ncbi Acute rheumatic fever
    Innocent Monya-Tambi
    Lancet 366:1355; author reply 1355-6. 2005
  82. ncbi Intramuscular penicillin is more effective than oral penicillin in secondary prevention of rheumatic fever--a systematic review
    Juliet Manyemba
    Clinical Age Research Unit, Guy s, King s and St Thomas s School of Medicine, King s College Hospital, London
    S Afr Med J 93:212-8. 2003
    ..Giving penicillin to these people can prevent recurrent attacks of RF and subsequent rheumatic heart disease. However, there is no agreement on the most effective method of giving penicillin...
  83. ncbi Cardiovascular disease in sub-Saharan Africa
    Lionel H Opie
    Circulation 112:3536-40. 2005
  84. ncbi Epidemiology and etiology of cardiomyopathy in Africa
    Karen Sliwa
    Department of Cardiology, Chris Hani Baragwanath Hospital, University of the Witwatersrand, Johannesburg, South Africa
    Circulation 112:3577-83. 2005
    ..The primary objective of this review was to summarize the current state of knowledge on the epidemiology and etiology of cardiomyopathy in people living in Africa and to identify new avenues for research...
  85. ncbi SAMJ--Africa's top open access medical journal
    Bongani M Mayosi
    S Afr Med J 95:809. 2005
  86. ncbi Towards a uniform plan for the control of rheumatic fever and rheumatic heart disease in Africa--the Awareness Surveillance Advocacy Prevention (A.S.A.P.) Programme
    Kate A Robertson
    New York Medical College, USA
    S Afr Med J 96:241. 2006
  87. ncbi Association between aldosterone production and variation in the 11beta-hydroxylase (CYP11B1) gene
    Helen Imrie
    Institute of Human Genetics, Central Parkway, Newcastle NE1 3BZ, United Kingdom
    J Clin Endocrinol Metab 91:5051-6. 2006
    ..However, the relative importance of polymorphisms in CYP11B1 and CYP11B2 in determining these phenotypes is unknown...
  88. ncbi Origins of computed tomography
    Christopher L Vaughan
    Lancet 369:1168. 2007
  89. ncbi Heart failure in sub-saharan Africa: time for action
    Albertino Damasceno
    Faculdade de Medicina, Universidade Eduardo Mondlane, Maputo, Mozambique
    J Am Coll Cardiol 50:1688-93. 2007
  90. ncbi Rheumatic fever and rheumatic heart disease: primary prevention is the cost effective option
    James Irlam
    Indian J Pediatr 75:86; author reply 86-7. 2008
  91. doi Ambulatory blood pressure is associated with polymorphic variation in P2X receptor genes
    Julian Palomino-Doza
    Institute of Human Genetics, Newcastle University, Newcastle upon Tyne, United Kingdom
    Hypertension 52:980-5. 2008
    ..Other suggestive associations were found, but these were nonsignificant after correction for multiple testing. These genetic data suggest that drugs affecting P2X receptor signaling may have promise as clinical antihypertensive agents...