C T T Edwards
Affiliation: University of Cape Town
Country: South Africa
- Population genetic estimation of the loss of genetic diversity during horizontal transmission of HIV-1Charles T T Edwards
Nuffield Department of Clinical Medicine, University of Oxford, The Peter Medawar Building for Pathogen Research, Oxford, OX1 3SY, UK
BMC Evol Biol 6:28. 2006..Despite this, the magnitude of this population bottleneck is unclear...
- Evolution of the human immunodeficiency virus envelope gene is dominated by purifying selectionC T T Edwards
Nuffield Department of Clinical Medicine, University of Oxford, UK, and Department of Pediatrics, The Johns Hopkins Hospital, Baltimore, MD 21287, USA
Genetics 174:1441-53. 2006..This suggests the presence of deleterious mutations. We therefore conclude that intrahost HIV-1 evolution in envelope is dominated by purifying selection against low-frequency deleterious mutations that do not reach fixation...
- Sexual transmission of single human immunodeficiency virus type 1 virions encoding highly polymorphic multisite cytotoxic T-lymphocyte escape variantsAnita Milicic
The Peter Medawar Building for Pathogen Research and The James Martin 21st Century School, Nuffield Department of Clinical Medicine, University of Oxford, South Parks Road, Oxford OX1 3SY, United Kingdom
J Virol 79:13953-62. 2005..In donors who are themselves controlling an early, acute infection, the precise timing of onward transmission is a crucial determinant of the viral variants available to compose the inoculum...
- Intrapatient escape in the A*0201-restricted epitope SLYNTVATL drives evolution of human immunodeficiency virus type 1 at the population levelCharles T T Edwards
Nuffield Department of Clinical Medicine, University of Oxford, United Kingdom
J Virol 79:9363-6. 2005..Using this approach, we revealed a pattern of A*0201-driven escape within patients, followed by the sustained transmission of these escape variants among patients irrespective of their HLA type...
- Inefficient cytotoxic T lymphocyte-mediated killing of HIV-1-infected cells in vivoBecca Asquith
Department of Zoology, University of Oxford, Oxford, United Kingdom
PLoS Biol 4:e90. 2006..We suggest that CTLs kill a large number of infected cells (about 10(7)) per day but are not responsible for the majority of infected cell death...