Karen Cohen

Summary

Affiliation: University of Cape Town
Country: South Africa

Publications

  1. pmc Safety and effectiveness of colistin compared with tobramycin for multi-drug resistant Acinetobacter baumannii infections
    Ronald Gounden
    Department of Medicine, Division of Clinical Pharmacology, University of Cape Town, Cape Town, South Africa
    BMC Infect Dis 9:26. 2009
  2. pmc The impact of the National HIV Health Care Worker Hotline on patient care in South Africa
    Briony S Chisholm
    Medicines Information Centre, University of Cape Town, Cape Town, South Africa
    AIDS Res Ther 8:4. 2011
  3. pmc Effect of rifampicin-based antitubercular therapy and the cytochrome P450 2B6 516G>T polymorphism on efavirenz concentrations in adults in South Africa
    Karen Cohen
    Division of Clinical Pharmacology, Department of Medicine, University of Cape Town, Cape Town, South Africa
    Antivir Ther 14:687-95. 2009
  4. ncbi request reprint Effect of rifampicin-based antitubercular therapy on nevirapine plasma concentrations in South African adults with HIV-associated tuberculosis
    Karen Cohen
    Division of Clinical Pharmacology, Department of Medicine, University of Cape Town, South Africa
    J Antimicrob Chemother 61:389-93. 2008
  5. doi request reprint Outcomes of nevirapine- and efavirenz-based antiretroviral therapy when coadministered with rifampicin-based antitubercular therapy
    Andrew Boulle
    School of Public Health and Family Medicine, University of Cape Town, Cape Town, South Africa
    JAMA 300:530-9. 2008
  6. doi request reprint Effectiveness and safety of antiretrovirals with rifampicin: crucial issues for high-burden countries
    Gary Maartens
    Division of Clinical Pharmacology, Department of Medicine, University of Cape Town, Cape Town, South Africa
    Antivir Ther 14:1039-43. 2009
  7. pmc Adverse Drug Reactions Causing Admission to Medical Wards: A Cross-Sectional Survey at 4 Hospitals in South Africa
    Johannes P Mouton
    From the Department of Medicine, Division of Clinical Pharmacology, University of Cape Town, Cape Town JPM, CN, NK, As, UM, MB, MFDS, RDW, GM, KC Department of Medicine, East London Hospital Complex and Walter Sisulu University, East London AGP Department of Medicine, Edendale Hospital, Pietermaritzburg, South Africa DPKW, US Centers for Disease Control and Prevention, Pretoria EUI, GA National Department of Health, Pretoria MD and Pharmaceutical Services, School of Health Sciences, University of KwaZulu Natal, Durban, South Africa MD
    Medicine (Baltimore) 95:e3437. 2016
  8. pmc Management of individuals requiring antiretroviral therapy and TB treatment
    Karen Cohen
    Division of Clinical Pharmacology, Department of Medicine, Cape Town, South Africa
    Curr Opin HIV AIDS 5:61-9. 2010
  9. pmc Cases of antiretroviral-associated gynaecomastia reported to the National HIV & Tuberculosis Health Care Worker Hotline in South Africa
    Christine Njuguna
    Division of Clinical Pharmacology, Department of Medicine, University of Cape Town, Cape Town, South Africa
    AIDS Res Ther 13:40. 2016
  10. pmc Efavirenz and rifampicin in the South African context: is there a need to dose-increase efavirenz with concurrent rifampicin therapy?
    Catherine Orrell
    Desmond Tutu HIV Centre, Institute of Infectious Disease and Molecular Medicine, University of Cape Town, Cape Town, South Africa
    Antivir Ther 16:527-34. 2011

Collaborators

Detail Information

Publications27

  1. pmc Safety and effectiveness of colistin compared with tobramycin for multi-drug resistant Acinetobacter baumannii infections
    Ronald Gounden
    Department of Medicine, Division of Clinical Pharmacology, University of Cape Town, Cape Town, South Africa
    BMC Infect Dis 9:26. 2009
    ..Nosocomial infections due to multi-drug resistant Acinetobacter baumannii are often treated with colistin, but there are few data comparing its safety and efficacy with other antimicrobials...
  2. pmc The impact of the National HIV Health Care Worker Hotline on patient care in South Africa
    Briony S Chisholm
    Medicines Information Centre, University of Cape Town, Cape Town, South Africa
    AIDS Res Ther 8:4. 2011
    ....
  3. pmc Effect of rifampicin-based antitubercular therapy and the cytochrome P450 2B6 516G>T polymorphism on efavirenz concentrations in adults in South Africa
    Karen Cohen
    Division of Clinical Pharmacology, Department of Medicine, University of Cape Town, Cape Town, South Africa
    Antivir Ther 14:687-95. 2009
    ..We explored the effect of rifampicin-based antitubercular therapy and the 516G>T polymorphism on efavirenz concentrations in HIV-infected patients in South Africa...
  4. ncbi request reprint Effect of rifampicin-based antitubercular therapy on nevirapine plasma concentrations in South African adults with HIV-associated tuberculosis
    Karen Cohen
    Division of Clinical Pharmacology, Department of Medicine, University of Cape Town, South Africa
    J Antimicrob Chemother 61:389-93. 2008
    ..We describe the steady-state pharmacokinetics of nevirapine during and after antitubercular therapy in South African patients...
  5. doi request reprint Outcomes of nevirapine- and efavirenz-based antiretroviral therapy when coadministered with rifampicin-based antitubercular therapy
    Andrew Boulle
    School of Public Health and Family Medicine, University of Cape Town, Cape Town, South Africa
    JAMA 300:530-9. 2008
    ..Rifampicin-based antitubercular therapy reduces the plasma concentrations of nevirapine and efavirenz. The virological consequences of these interactions are not well described...
  6. doi request reprint Effectiveness and safety of antiretrovirals with rifampicin: crucial issues for high-burden countries
    Gary Maartens
    Division of Clinical Pharmacology, Department of Medicine, University of Cape Town, Cape Town, South Africa
    Antivir Ther 14:1039-43. 2009
    ....
  7. pmc Adverse Drug Reactions Causing Admission to Medical Wards: A Cross-Sectional Survey at 4 Hospitals in South Africa
    Johannes P Mouton
    From the Department of Medicine, Division of Clinical Pharmacology, University of Cape Town, Cape Town JPM, CN, NK, As, UM, MB, MFDS, RDW, GM, KC Department of Medicine, East London Hospital Complex and Walter Sisulu University, East London AGP Department of Medicine, Edendale Hospital, Pietermaritzburg, South Africa DPKW, US Centers for Disease Control and Prevention, Pretoria EUI, GA National Department of Health, Pretoria MD and Pharmaceutical Services, School of Health Sciences, University of KwaZulu Natal, Durban, South Africa MD
    Medicine (Baltimore) 95:e3437. 2016
    ..Identification and management of these ADRs should be considered in HIV and tuberculosis care and treatment programs and should be emphasized in health care worker training programmes. ..
  8. pmc Management of individuals requiring antiretroviral therapy and TB treatment
    Karen Cohen
    Division of Clinical Pharmacology, Department of Medicine, Cape Town, South Africa
    Curr Opin HIV AIDS 5:61-9. 2010
    ..The incidence of TB in patients established on ART remains high. Co-treatment presents several management challenges. Recent data on these management issues are reviewed...
  9. pmc Cases of antiretroviral-associated gynaecomastia reported to the National HIV & Tuberculosis Health Care Worker Hotline in South Africa
    Christine Njuguna
    Division of Clinical Pharmacology, Department of Medicine, University of Cape Town, Cape Town, South Africa
    AIDS Res Ther 13:40. 2016
    ..We describe the clinical characteristics, management and outcomes of gynaecomastia cases reported to the National HIV & Tuberculosis Health Care Worker Hotline in South Africa...
  10. pmc Efavirenz and rifampicin in the South African context: is there a need to dose-increase efavirenz with concurrent rifampicin therapy?
    Catherine Orrell
    Desmond Tutu HIV Centre, Institute of Infectious Disease and Molecular Medicine, University of Cape Town, Cape Town, South Africa
    Antivir Ther 16:527-34. 2011
    ..Increasing efavirenz (EFV) dose from 600 mg to 800 mg daily has been suggested with concomitant rifampicin (RFN), as induction of cytochrome P450 isoenzymes may reduce EFV plasma concentrations...
  11. pmc Antiretroviral therapy and early mortality in South Africa
    Andrew Boulle
    School of Public Health and Family Medicine, University of Cape Town, Cape Town, South Africa
    Bull World Health Organ 86:678-87. 2008
    ..To describe province-wide outcomes and temporal trends of the Western Cape Province antiretroviral treatment (ART) programme 5 years since inception, and to demonstrate the utility of the WHO monitoring system for ART...
  12. doi request reprint Severe antiretroviral-associated skin reactions in South African patients: a case series and case-control analysis
    Annemie Stewart
    Division of Clinical Pharmacology, Department of Medicine, University of Cape Town, Cape Town, South Africa
    Pharmacoepidemiol Drug Saf 25:1313-1319. 2016
    ..We reviewed cases of severe skin reactions admitted to a tertiary hospital in Cape Town, South Africa. We identified associations with severe skin reactions in patients on cART...
  13. ncbi request reprint Dosage adjustment in medical patients with renal impairment at Groote Schuur Hospital
    Eric Decloedt
    Division of Clinical Pharmacology, Department of Internal Medicine, UCT
    S Afr Med J 100:304-6. 2010
    ..Many drugs are eliminated by the kidneys and therefore may require dose adjustment in patients with renal impairment. The need for dose adjustment is frequently neglected by prescribers...
  14. doi request reprint Effect of mid-dose efavirenz concentrations and CYP2B6 genotype on viral suppression in patients on first-line antiretroviral therapy
    Catherine Orrell
    Desmond Tutu HIV Centre, Institute of Infectious Disease and Molecular Medicine and Department of Medicine, University of Cape Town, Cape Town, South Africa Electronic address
    Int J Antimicrob Agents 47:466-72. 2016
    ..Knowledge of CYP2B6 metaboliser genotype is not required for prediction of virological outcomes. ..
  15. doi request reprint Clinician compliance with laboratory monitoring and prescribing guidelines in HIV-1-infected patients receiving tenofovir
    Reneé de Waal
    Centre for Infectious Disease Epidemiology and Research, School of Public Health and Family Medicine, Faculty of Health Sciences, University of Cape Town, South Africa
    S Afr Med J 106:52-3. 2016
    ....
  16. pmc Adverse Drug Reactions Reported to a National HIV & Tuberculosis Health Care Worker Hotline in South Africa: Description and Prospective Follow-Up of Reports
    Christine Njuguna
    Division of Clinical Pharmacology, Department of Medicine, University of Cape Town, Cape Town, South Africa
    Drug Saf 39:159-69. 2016
    ..We describe suspected ADRs reported to the hotline by HCWs, concordance with advice, and patient outcomes...
  17. doi request reprint A Randomized Controlled Trial of Real-Time Electronic Adherence Monitoring With Text Message Dosing Reminders in People Starting First-Line Antiretroviral Therapy
    Catherine Orrell
    Desmond Tutu HIV Centre, Institute of Infectious Disease and Molecular Medicine and Department of Medicine, University of Cape Town, Cape Town, South Africa Division of Clinical Pharmacology, Department of Medicine, University of Cape Town, Cape Town, South Africa Department of Statistical Science, University of Cape Town, Cape Town, South Africa Harvard Medical School, Boston, MA Massachusetts General Hospital Center for Global Health, Boston, MA and Ragon Institute of Massachusetts General Hospital, Boston, MA
    J Acquir Immune Defic Syndr 70:495-502. 2015
    ..There are conflicting findings about whether mobile phone text message reminders impact on antiretroviral adherence. We hypothesized that text reminders sent when dosing was late would improve adherence and HIV viral suppression...
  18. doi request reprint Provision of antiretroviral therapy in South Africa: the nuts and bolts
    Linda Gail Bekker
    The Desmond Tutu HIV Centre, IDM and Medicine, University of Cape Town, Cape Town, South Africa
    Antivir Ther 19:105-16. 2014
    ....
  19. pmc The Cape Town Clinical Decision Rule for Streptococcal Pharyngitis in Children
    Mark Emmanuel Engel
    1Department of Medicine, Groote Schuur Hospital and University of Cape Town, Cape Town, South Africa 2Division of Clinical Pharmacology, Department of Medicine, Groote Schuur Hospital and University of Cape Town, Cape Town, South Africa 3Department of Medicine, Groote Schuur Hospital and University of Cape Town, Cape Town, South Africa 4Division of Medical Microbiology, Department of Pathology, Faculty of Medicine and Health Sciences, Stellenbosch University and NHLS Tygerberg, Tygerberg, South Africa 5Division of Clinical Pharmacology, Department of Medicine, Groote Schuur Hospital and University of Cape Town, Cape Town, South Africa 6Department of Medicine, Division of Infectious Diseases, University of Tennessee Health Science Center, Memphis, TN, USA
    Pediatr Infect Dis J . 2016
    ..We developed a locally applicable CDR while evaluating existing CDRs for diagnosing GAS pharyngitis in South African children...
  20. ncbi request reprint Key toxicity issues with the WHO-recommended first-line antiretroviral therapy regimen
    Johannes P Mouton
    a Division of Clinical Pharmacology, Department of Medicine, University of Cape Town, Cape Town, South Africa
    Expert Rev Clin Pharmacol . 2016
    ..WHO recommends tenofovir, efavirenz, and lamivudine or emtricitabine for first-line antiretroviral therapy (ART) in adults, which replaced more toxic regimens using stavudine, zidovudine or nevirapine...
  21. pmc Random lopinavir concentrations predict resistance on lopinavir-based antiretroviral therapy
    Richard Court
    Division of Clinical Pharmacology, Department of Medicine, University of Cape Town, Cape Town, South Africa Electronic address
    Int J Antimicrob Agents 48:158-62. 2016
    ....
  22. pmc Mortality from adverse drug reactions in adult medical inpatients at four hospitals in South Africa: a cross-sectional survey
    Johannes P Mouton
    Division of Clinical Pharmacology, Department of Medicine, University of Cape Town, Cape Town
    Br J Clin Pharmacol 80:818-26. 2015
    ..We determined the proportion of deaths in South African medical inpatients attributable to ADRs, and their preventability, stratified by human immunodeficiency virus (HIV) status...
  23. pmc Systematic review of antiretroviral-associated lipodystrophy: lipoatrophy, but not central fat gain, is an antiretroviral adverse drug reaction
    Reneé de Waal
    Division of Clinical Pharmacology, Department of Medicine, University of Cape Town, Cape Town, South Africa
    PLoS ONE 8:e63623. 2013
    ..Lipoatrophy and/or central fat gain are observed frequently in patients on antiretroviral therapy (ART). Both are assumed to be antiretroviral adverse drug reactions...
  24. doi request reprint N-acetylcysteine for non-paracetamol drug-induced liver injury: a systematic review
    Mohamed Farouk Chughlay
    Division of Clinical Pharmacology, Department of Medicine, Faculty of Health Sciences, University of Cape Town, Anzio Road, Observatory, 7925, Cape Town
    Br J Clin Pharmacol 81:1021-9. 2016
    ..N-acetylcysteine (NAC) may be useful in the management of non-paracetamol drug-induced liver injury (DILI). Our objective was to review systematically evidence for the use of NAC as a therapeutic option for non-paracetamol DILI...
  25. pmc Antiretroviral Therapy, Especially Efavirenz, Is Associated with Low Bone Mineral Density in HIV-Infected South Africans
    Joel A Dave
    Division of Diabetic Medicine and Endocrinology, Department of Medicine, University of Cape Town, Cape Town, South Africa
    PLoS ONE 10:e0144286. 2015
    ..We determined the prevalence and correlates of low bone mineral density (BMD) in HIV-infected South Africans as there is a paucity of such data from Africa...
  26. doi request reprint Nevirapine concentrations in preterm and low birth weight HIV-exposed infants: implications for dosing recommendations
    Reneé de Waal
    From the Division of Clinical Pharmacology, Department of Medicine, and Department of Paediatrics, University of Cape Town, Cape Town and Department of Paediatrics and Child Health, Stellenbosch University, Stellenbosch, South Africa
    Pediatr Infect Dis J 33:1231-3. 2014
    ..Concentrations decreased with treatment duration. Routine dose increase at 14 days should be considered. ..
  27. ncbi request reprint Antiretroviral therapy in a community clinic--early lessons from a pilot project
    Linda Gail Bekker
    HIV Research Unit, University of Cape Town, Provincial Administration of the Western Cape
    S Afr Med J 93:458-62. 2003
    ..To report on operational and clinical problems encountered during the first 6 months of a community-based antiretroviral therapy (ART) programme...