Eric Bateman

Summary

Affiliation: University of Cape Town
Country: South Africa

Publications

  1. doi request reprint Stability of asthma control with regular treatment: an analysis of the Gaining Optimal Asthma controL (GOAL) study
    E D Bateman
    Division of Pulmonology, Department of Medicine, University of Cape Town, Cape Town, South Africa
    Allergy 63:932-8. 2008
  2. doi request reprint Roflumilast combined with montelukast versus montelukast alone as add-on treatment in patients with moderate-to-severe asthma
    Eric D Bateman
    Division of Pulmonology, Department of Medicine, University of Cape Town, Cape Town, South Africa Electronic address
    J Allergy Clin Immunol 138:142-149.e8. 2016
  3. doi request reprint Roflumilast for asthma: Efficacy findings in non-placebo-controlled comparator and dosing studies
    E D Bateman
    Division of Pulmonology, Department of Medicine, University of Cape Town Lung Institute, Cape Town, South Africa Electronic address
    Pulm Pharmacol Ther 35:S11-9. 2015
  4. doi request reprint The asthma-COPD overlap syndrome: towards a revised taxonomy of chronic airways diseases?
    Eric D Bateman
    Division of Pulmonology, Department of Medicine, Faculty of Health Sciences, University of Cape Town, Cape Town, South Africa Electronic address
    Lancet Respir Med 3:719-28. 2015
  5. pmc Aclidinium bromide and formoterol fumarate as a fixed-dose combination in COPD: pooled analysis of symptoms and exacerbations from two six-month, multicentre, randomised studies (ACLIFORM and AUGMENT)
    Eric D Bateman
    Division of Pulmonology, Department of Medicine, University of Cape Town, George Street, Mowbray, 7700, Cape Town, South Africa
    Respir Res 16:92. 2015
  6. doi request reprint Magnitude of effect of asthma treatments on Asthma Quality of Life Questionnaire and Asthma Control Questionnaire scores: Systematic review and network meta-analysis
    Eric D Bateman
    Department of Medicine, University of Cape Town, Cape Town, South Africa Electronic address
    J Allergy Clin Immunol 136:914-22. 2015
  7. doi request reprint Development and validation of a novel risk score for asthma exacerbations: The risk score for exacerbations
    Eric D Bateman
    Division of Pulmonology, Department of Medicine, University of Cape Town, Cape Town, South Africa Electronic address
    J Allergy Clin Immunol 135:1457-64.e4. 2015
  8. pmc Efficacy and safety of aclidinium bromide/formoterol fumarate fixed-dose combinations compared with individual components and placebo in patients with COPD (ACLIFORM-COPD): a multicentre, randomised study
    Dave Singh
    University of Manchester, Medicines Evaluation Unit, Langley Building, University Hospital of South Manchester NHS Foundation Trust, Southmoor Road, Manchester M23 9QZ, UK
    BMC Pulm Med 14:178. 2014
  9. pmc Efficacy and safety of once-daily fluticasone furoate 50 mcg in adults with persistent asthma: a 12-week randomized trial
    Paul M O'Byrne
    Michael G DeGroote School of Medicine, Hamilton, ON, Canada
    Respir Res 15:88. 2014
  10. pmc Comparison of vilanterol, a novel long-acting beta2 agonist, with placebo and a salmeterol reference arm in asthma uncontrolled by inhaled corticosteroids
    Jan Lotvall
    Krefting Research Centre, University of Gothenburg, Gothenburg, Sweden
    J Negat Results Biomed 13:9. 2014

Detail Information

Publications69

  1. doi request reprint Stability of asthma control with regular treatment: an analysis of the Gaining Optimal Asthma controL (GOAL) study
    E D Bateman
    Division of Pulmonology, Department of Medicine, University of Cape Town, Cape Town, South Africa
    Allergy 63:932-8. 2008
    ....
  2. doi request reprint Roflumilast combined with montelukast versus montelukast alone as add-on treatment in patients with moderate-to-severe asthma
    Eric D Bateman
    Division of Pulmonology, Department of Medicine, University of Cape Town, Cape Town, South Africa Electronic address
    J Allergy Clin Immunol 138:142-149.e8. 2016
    ..We hypothesized that this drug might provide benefit if combined with montelukast, a leukotriene receptor antagonist, in patients whose symptoms are uncontrolled by inhaled corticosteroids and long-acting β-agonists...
  3. doi request reprint Roflumilast for asthma: Efficacy findings in non-placebo-controlled comparator and dosing studies
    E D Bateman
    Division of Pulmonology, Department of Medicine, University of Cape Town Lung Institute, Cape Town, South Africa Electronic address
    Pulm Pharmacol Ther 35:S11-9. 2015
    ..Roflumilast, a phosphodiesterase-4 inhibitor, has an established place in the treatment of chronic obstructive pulmonary disease. Its potential role as a treatment for asthma is unclear...
  4. doi request reprint The asthma-COPD overlap syndrome: towards a revised taxonomy of chronic airways diseases?
    Eric D Bateman
    Division of Pulmonology, Department of Medicine, Faculty of Health Sciences, University of Cape Town, Cape Town, South Africa Electronic address
    Lancet Respir Med 3:719-28. 2015
    ..This Review considers the epidemiology, mechanisms of disease, current attempts to define and diagnose ACOS, existing and potential treatment options, and new approaches to the phenotyping and taxonomy of airway diseases. ..
  5. pmc Aclidinium bromide and formoterol fumarate as a fixed-dose combination in COPD: pooled analysis of symptoms and exacerbations from two six-month, multicentre, randomised studies (ACLIFORM and AUGMENT)
    Eric D Bateman
    Division of Pulmonology, Department of Medicine, University of Cape Town, George Street, Mowbray, 7700, Cape Town, South Africa
    Respir Res 16:92. 2015
    ..We examined these outcomes in a pre-specified analysis of pooled data from two 24-week, double-blind, parallel-group, active- and placebo-controlled, multicentre, randomised Phase III studies (ACLIFORM and AUGMENT)...
  6. doi request reprint Magnitude of effect of asthma treatments on Asthma Quality of Life Questionnaire and Asthma Control Questionnaire scores: Systematic review and network meta-analysis
    Eric D Bateman
    Department of Medicine, University of Cape Town, Cape Town, South Africa Electronic address
    J Allergy Clin Immunol 136:914-22. 2015
    ....
  7. doi request reprint Development and validation of a novel risk score for asthma exacerbations: The risk score for exacerbations
    Eric D Bateman
    Division of Pulmonology, Department of Medicine, University of Cape Town, Cape Town, South Africa Electronic address
    J Allergy Clin Immunol 135:1457-64.e4. 2015
    ..Identifying patients at risk of future severe asthma exacerbations, those whose asthma might be less treatment responsive, or both might guide treatment selection...
  8. pmc Efficacy and safety of aclidinium bromide/formoterol fumarate fixed-dose combinations compared with individual components and placebo in patients with COPD (ACLIFORM-COPD): a multicentre, randomised study
    Dave Singh
    University of Manchester, Medicines Evaluation Unit, Langley Building, University Hospital of South Manchester NHS Foundation Trust, Southmoor Road, Manchester M23 9QZ, UK
    BMC Pulm Med 14:178. 2014
    ..The efficacy and safety of aclidinium/formoterol versus monotherapy and placebo in patients with COPD was assessed...
  9. pmc Efficacy and safety of once-daily fluticasone furoate 50 mcg in adults with persistent asthma: a 12-week randomized trial
    Paul M O'Byrne
    Michael G DeGroote School of Medicine, Hamilton, ON, Canada
    Respir Res 15:88. 2014
    ..placebo in asthma patients. This study evaluated the efficacy and safety of FF 50 mcg compared with placebo in asthma patients uncontrolled by non-ICS therapy...
  10. pmc Comparison of vilanterol, a novel long-acting beta2 agonist, with placebo and a salmeterol reference arm in asthma uncontrolled by inhaled corticosteroids
    Jan Lotvall
    Krefting Research Centre, University of Gothenburg, Gothenburg, Sweden
    J Negat Results Biomed 13:9. 2014
    ..placebo. An active control arm received salmeterol (SAL) twice daily. All patients were maintained on a stable background dose of ICS...
  11. pmc Cost-effectiveness of roflumilast as an add-on treatment to long-acting bronchodilators in the treatment of COPD associated with chronic bronchitis in the United Kingdom
    Yevgeniy Samyshkin
    IMS Health, 210 Pentonville Road, London, N1 9JY, UK
    Eur J Health Econ 15:69-82. 2014
    ....
  12. pmc Efficacy and safety of fluticasone furoate 100 μg and 200 μg once daily in the treatment of moderate-severe asthma in adults and adolescents: a 24-week randomised study
    Ashley Woodcock
    Institute of Inflammation and Repair, University of Manchester, University Hospital of South Manchester, Manchester M23 9LT, UK
    BMC Pulm Med 14:113. 2014
    ..This study was performed to descriptively assess the efficacy and safety of two doses of FF, with no planned formal statistical hypothesis testing...
  13. pmc A blinded evaluation of the efficacy and safety of glycopyrronium, a once-daily long-acting muscarinic antagonist, versus tiotropium, in patients with COPD: the GLOW5 study
    Kenneth R Chapman
    Asthma and Airway Centre, University Health Network, Toronto Western Hospital, Rm 7 451 East Wing, 399 Bathurst Street, Toronto, ON, Canada
    BMC Pulm Med 14:4. 2014
    ..Previous studies have compared glycopyrronium with open-label tiotropium. In the GLOW5 study, we compare glycopyrronium with blinded tiotropium...
  14. pmc Dual bronchodilation with QVA149 versus single bronchodilator therapy: the SHINE study
    Eric D Bateman
    University of Cape Town, Cape Town, South Africa
    Eur Respir J 42:1484-94. 2013
    ....
  15. pmc Once-daily fluticasone furoate (FF)/vilanterol reduces risk of severe exacerbations in asthma versus FF alone
    Eric D Bateman
    Department of Medicine, University of Cape Town, Cape Town, South Africa
    Thorax 69:312-9. 2014
    ..However, there is ongoing debate regarding the risk-benefit ratio of using LABA in asthma...
  16. pmc Implementing nurse-initiated and managed antiretroviral treatment (NIMART) in South Africa: a qualitative process evaluation of the STRETCH trial
    Daniella Georgeu
    Knowledge Translation Unit, University of Cape Town Lung Institute, University of Cape Town, George Street, Mowbray 7700, Cape Town, South Africa
    Implement Sci 7:66. 2012
    ..This study was conducted alongside the trial to develop a contextualised understanding of factors affecting the implementation of the programme...
  17. doi request reprint Pharmacodynamics of GSK961081, a bi-functional molecule, in patients with COPD
    Eric D Bateman
    University of Cape Town Lung Institute, George Street, Mowbray 7700, Cape Town, South Africa
    Pulm Pharmacol Ther 26:581-7. 2013
    ..GSK961081 demonstrated sustained bronchodilation similar to TIO + SAL, but with a more rapid onset, and was well tolerated at the tested doses...
  18. doi request reprint Efficacy and safety of high-dose ciclesonide for the treatment of severe asthma
    Eric D Bateman
    Division of Pulmonology, Department of Medicine, University of Cape Town, George Street, Mowbray 7700, Cape Town, South Africa
    Expert Rev Respir Med 7:339-48. 2013
    ....
  19. doi request reprint Efficacy and safety of the long-acting muscarinic antagonist GSK233705 delivered once daily in patients with COPD
    Eric Bateman
    Department of Medicine, University of Cape Town, Cape Town, South Africa
    Clin Respir J 6:248-57. 2012
    ..GSK233705 is a recently developed inhaled anticholinergic being investigated for the potential treatment of chronic obstructive pulmonary disease (COPD)...
  20. pmc Fluticasone furoate: once-daily evening treatment versus twice-daily treatment in moderate asthma
    Ashley Woodcock
    School of Translational Medicine, University of Manchester, Manchester, UK
    Respir Res 12:160. 2011
    ..The objectives of this study were to compare the efficacy and safety of once-daily (OD) evening and twice-daily (BD) regimens of the novel inhaled corticosteroid fluticasone furoate (FF) in asthma patients...
  21. pmc Global asthma prevalence in adults: findings from the cross-sectional world health survey
    Teresa To
    Child Health Evaluative Sciences, The Hospital for Sick Children, Toronto, Ontario, Canada
    BMC Public Health 12:204. 2012
    ..We set out to generate estimates of the global burden of asthma in adults, which may inform the development of strategies to address this common disease...
  22. doi request reprint Dose effect of once-daily fluticasone furoate in persistent asthma: a randomized trial
    Eric D Bateman
    Department of Medicine, University of Cape Town, Cape Town, South Africa
    Respir Med 106:642-50. 2012
    ....
  23. pmc Strengthening health human resources and improving clinical outcomes through an integrated guideline and educational outreach in resource-poor settings: a cluster-randomized trial
    Michael J Schull
    Dignitas International, 2 Adelaide Street West, Suite 200, Toronto, M5H 1L6, Canada
    Trials 11:118. 2010
    ..This study will test an adapted primary care health care worker training and guideline intervention, Practical Approach to Lung Health and HIV/AIDS Malawi (PALM PLUS), on staff retention and satisfaction, and quality of patient care...
  24. pmc Efficacy in asthma of once-daily treatment with fluticasone furoate: a randomized, placebo-controlled trial
    Ashley Woodcock
    School of Translational Medicine, Manchester Academic Health Science Centre, University of Manchester, UK
    Respir Res 12:132. 2011
    ....
  25. pmc Efficacy and safety of once-daily aclidinium in chronic obstructive pulmonary disease
    Paul W Jones
    St George s, University of London, London, UK
    Respir Res 12:55. 2011
    ..The long-term efficacy and safety of aclidinium bromide, a novel, long-acting muscarinic antagonist, were investigated in patients with moderate to severe chronic obstructive pulmonary disease (COPD)...
  26. pmc Task shifting and integration of HIV care into primary care in South Africa: the development and content of the streamlining tasks and roles to expand treatment and care for HIV (STRETCH) intervention
    Kerry E Uebel
    Knowledge Translation Unit, University of Cape Town Lung Institute, University of Cape Town, Cape Town, South Africa
    Implement Sci 6:86. 2011
    ..This paper describes the development and content of an intervention involving these two strategies, as part of the Streamlining Tasks and Roles to Expand Treatment and Care for HIV (STRETCH) pragmatic randomised controlled trial...
  27. pmc From PALSA PLUS to PALM PLUS: adapting and developing a South African guideline and training intervention to better integrate HIV/AIDS care with primary care in rural health centers in Malawi
    Michael J Schull
    Dignitas International, 2 Adelaide Street West, Suite 200, Toronto, M5H 1L6, Canada
    Implement Sci 6:82. 2011
    ..We adapted it to align with Malawi's national treatment protocols, more varied healthcare workforce, and weaker health system infrastructure...
  28. pmc Evaluating a streamlined clinical tool and educational outreach intervention for health care workers in Malawi: the PALM PLUS case study
    Sumeet Sodhi
    Dignitas International, 2 Adelaide Street West, Suite 200, Toronto, M5H 1L6, Canada
    BMC Int Health Hum Rights 11:S11. 2011
    ..Key barriers to treatment scale up are shortages of trained health care workers, and challenges integrating HIV/AIDS care with primary care...
  29. doi request reprint Roflumilast with long-acting β2-agonists for COPD: influence of exacerbation history
    E D Bateman
    University of Cape Town Lung Institute, Cape Town, South Africa
    Eur Respir J 38:553-60. 2011
    ..No differences arose in adverse events between these subgroups. Roflumilast may be used to reduce exacerbations and improve dyspnoea and lung function, without increasing adverse events in COPD patients receiving concomitant LABAs...
  30. doi request reprint Alternative mechanisms for tiotropium
    E D Bateman
    Division of Pulmonology, Department of Medicine, University of Cape Town, Cape Town, South Africa
    Pulm Pharmacol Ther 22:533-42. 2009
    ..This article summarizes data from a variety of investigations that provide insights into possible mechanisms to account for the effects of tiotropium. The report summarizes the discussion on basic and clinical research in this field...
  31. doi request reprint Overall asthma control: the relationship between current control and future risk
    Eric D Bateman
    Division of Pulmonology, Department of Medicine, University of Cape Town, Cape Town, South Africa
    J Allergy Clin Immunol 125:600-8, 608.e1-608.e6. 2010
    ..Asthma guidelines emphasize both maintaining current control and reducing future risk, but the relationship between these 2 targets is not well understood...
  32. doi request reprint A one-year trial of tiotropium Respimat plus usual therapy in COPD patients
    E D Bateman
    Division of Pulmonology, Department of Medicine, University of Cape Town, Mowbray, Cape Town, South Africa
    Respir Med 104:1460-72. 2010
    ..The protocol is registered on the European Clinical Trials Database as trial number 2006-001009-27 and in the ClinicalTrials.gov database as NCT00387088...
  33. doi request reprint Systems for the management of respiratory disease in primary care--an international series: South Africa
    Eric Bateman
    Division of Pulmonology, Department of Medicine, University of Cape Town, and University of Cape Town Lung Institute, Cape Town, South Africa
    Prim Care Respir J 18:69-75. 2009
    ....
  34. ncbi request reprint Meta-analysis: effects of adding salmeterol to inhaled corticosteroids on serious asthma-related events
    Eric Bateman
    Division of Pulmonology, Department of Medicine, University of Cape Town, Cape Town, South Africa
    Ann Intern Med 149:33-42. 2008
    ..Recent analyses have suggested an increased risk for serious asthma-related adverse events in patients receiving long-acting beta-agonists...
  35. doi request reprint Randomized comparison of ciclesonide 160 and 640 microg/day in severe asthma
    E D Bateman
    Division of Pulmonology, Department of Medicine, Faculty of Health Sciences, University of Cape Town, PO Box 34560, Groote Schuur 7937, Cape Town, South Africa
    Pulm Pharmacol Ther 21:489-98. 2008
    ....
  36. ncbi request reprint Comparison of twice-daily inhaled ciclesonide and fluticasone propionate in patients with moderate-to-severe persistent asthma
    E D Bateman
    Division of Pulmonology, Department of Medicine, Faculty of Health Sciences, University of Cape Town, PO Box 34560, Groote Schuur 7937, Cape Town, South Africa
    Pulm Pharmacol Ther 21:264-75. 2008
    ..To investigate the relative efficacy of ciclesonide and fluticasone propionate (FP) administered at comparable microgram doses in maintaining asthma control in patients with moderate-to-severe persistent asthma...
  37. pmc Overall asthma control achieved with budesonide/formoterol maintenance and reliever therapy for patients on different treatment steps
    Eric D Bateman
    Division of Pulmonology, Department of Medicine, University of Cape Town, Cape Town, South Africa
    Respir Res 12:38. 2011
    ....
  38. pmc Efficacy and safety of tiotropium Respimat SMI in COPD in two 1-year randomized studies
    Eric Bateman
    Division of Pulmonology, Department of Medicine, University of Cape Town, Cape Town, South Africa
    Int J Chron Obstruct Pulmon Dis 5:197-208. 2010
    ..Tiotropium Respimat SMI 5 microg demonstrated sustained improvements in patients with COPD relative to placebo and similar to the 10 microg dose but with a lower frequency of anticholinergic adverse events...
  39. ncbi request reprint Is overall asthma control being achieved? A hypothesis-generating study
    E D Bateman
    UCT Lung Institute, University of Cape Town, South Africa
    Eur Respir J 17:589-95. 2001
    ..Future research will include a randomized controlled study designed to assess the proportion of patients able to achieve overall control of asthma when treatment is titrated appropriately...
  40. ncbi request reprint Ciclesonide reduces the need for oral steroid use in adult patients with severe, persistent asthma
    Eric Bateman
    University of Cape Town Lung Institute, PO Box 34560, Groote Schuur 7937, Cape Town, South Africa
    Chest 129:1176-87. 2006
    ..The potential of ciclesonide, a novel ICS, to reduce OCS use in patients with severe, persistent asthma was evaluated in this study...
  41. ncbi request reprint Guideline for the management of chronic obstructive pulmonary disease (COPD): 2004 revision
    E D Bateman
    University of Cape Town Lung Institute
    S Afr Med J 94:559-75. 2004
    ..The development of both long-acting beta2-agonist and anticholinergic drugs for use in COPD. Emerging evidence on a limited role for inhaled corticosteroids in the treatment of COPD...
  42. ncbi request reprint Clinical equivalence of salmeterol/fluticasone propionate in combination (50/100 microg twice daily) when administered via a chlorofluorocarbon-free metered dose inhaler or dry powder inhaler to patients with mild-to-moderate asthma
    E D Bateman
    UCT Lung Institute, Groote Schuur, Cape Town, South Africa
    Respir Med 95:136-46. 2001
    ..Patients switching to SALM/FP from other MDI-based asthma treatments may now do so without a change of delivery device...
  43. ncbi request reprint Aetiology and outcome of pneumonia in human immunodeficiency virus-infected children hospitalized in South Africa
    H J Zar
    Department of Paediatrics, University of Cape Town South Africa
    Acta Paediatr 90:119-25. 2001
    ..Thirty-one (20%) HIV-positive and 8 (8%) HIV-negative children died [RR 1.16 (95% CI 1.05-1.28), p=0.008]; using multiple logistic regression, PCP was the only risk factor for mortality (p = 0.03)...
  44. ncbi request reprint Measuring asthma control
    E D Bateman
    University of Cape Town, Cape Town, South Africa
    Curr Opin Allergy Clin Immunol 1:211-6. 2001
    ..The potential value of the wider use of a composite measure of clinical control is being increasingly recognized, and further attempts to develop, validate and apply a simple tool suitable for use in primary care are underway...
  45. ncbi request reprint Achieving guideline-based asthma control: does the patient benefit?
    E D Bateman
    UCT Lung Institute, University of Cape Town, South Africa
    Eur Respir J 20:588-95. 2002
    ..Guideline-based asthma control is therefore beneficial to the patient and should be tested in prospective studies...
  46. pmc Budesonide/formoterol and formoterol provide similar rapid relief in patients with acute asthma showing refractoriness to salbutamol
    E D Bateman
    University of Cape Town Lung Institute, Cape Town, South Africa
    Respir Res 7:13. 2006
    ..To compare the efficacy and safety of budesonide/formoterol (Symbicort) with formoterol (Oxis) in the treatment of patients with acute asthma who showed evidence of refractoriness to short-acting beta2-agonist therapy...
  47. ncbi request reprint Poikiloderma, tendon contracture and pulmonary fibrosis: a new autosomal dominant syndrome?
    N P Khumalo
    Division of Dermatology, Groote Schuur Hospital, Cape Town, South Africa
    Br J Dermatol 155:1057-61. 2006
    ..The manifestations in this family differ from other poikilodermata and, to the best of our knowledge, have not been previously documented...
  48. ncbi request reprint The correlation between asthma control and health status: the GOAL study
    E D Bateman
    University of Cape Town, Cape Town, South Africa
    Eur Respir J 29:56-62. 2007
    ..The difference in Asthma Quality of Life Questionnaire scores between total control and well-controlled confirms that patients distinguish even between these high levels of control...
  49. ncbi request reprint Comparable spirometric efficacy of tiotropium compared with salmeterol plus fluticasone in patients with COPD: a pilot study
    E D Bateman
    Division of Pulmonology, Department of Medicine, Faculty of Health Sciences, University of Cape Town, PO Box 34560, Groote Schuur 7937, Cape Town, South Africa
    Pulm Pharmacol Ther 21:20-5. 2008
    ....
  50. ncbi request reprint Comparison of respiratory effects of two cardioselective beta-blockers, celiprolol and atenolol, in asthmatics with mild to moderate hypertension
    A I van Zyl
    Ischaemic Heart Disease Research Unit, University of Cape Town, South Africa
    Chest 95:209-13. 1989
    ..When given acutely, celiprolol appeared to have acute bronchosparing properties, possibly providing a greater margin of respiratory safety than atenolol...
  51. doi request reprint Global strategy for asthma management and prevention: GINA executive summary
    E D Bateman
    University of Cape Town Lung Institute, PO Box 34560, Groote School, 7700 Mowbray, Cape Town, South Africa
    Eur Respir J 31:143-78. 2008
    ..The importance of the patient-care giver partnership and guided self-management, along with setting goals for treatment, are also emphasised...
  52. doi request reprint Utility of quantitative T-cell responses versus unstimulated interferon-{gamma} for the diagnosis of pleural tuberculosis
    K Dheda
    Lung Infection and Immunity Unit, Division of Pulmonology, Dept of Medicine, University of Cape Town, J flr, Old Main Bldg, Groote Schuur Hospital, Observatory, Cape Town 7925, South Africa
    Eur Respir J 34:1118-26. 2009
    ..The antigen-specific T-cell IGRAs were limited by suboptimal accuracy and the inability to isolate sufficient mononuclear cells to perform the assay...
  53. doi request reprint Quantitative lung T cell responses aid the rapid diagnosis of pulmonary tuberculosis
    K Dheda
    Lung Infection and Immunity Unit and CTBRI, UCT Lung Institute and Division of Pulmonology, Department of Medicine, University of Cape Town, South Africa
    Thorax 64:847-53. 2009
    ..The diagnosis of smear-negative pulmonary tuberculosis (TB) is problematic. There are limited data on the profile of alveolar TB antigen-specific T cells, and their utility for the rapid immunodiagnosis of pulmonary TB is unclear...
  54. pmc Innovating to improve primary care in less developed countries: towards a global model
    Lara Fairall
    Knowledge Translation Unit, University of Cape Town Lung Institute, South Africa
    BMJ Innov 1:196-203. 2015
    ..Global health would probably benefit from less time and money spent developing new innovations and more spent on finding ways to spread those we already have...
  55. pmc Task shifting of antiretroviral treatment from doctors to primary-care nurses in South Africa (STRETCH): a pragmatic, parallel, cluster-randomised trial
    Lara Fairall
    Knowledge Translation Unit, University of Cape Town Lung Institute, University of Cape Town, Cape Town, South Africa
    Lancet 380:889-98. 2012
    ....
  56. pmc Occupational allergy and asthma among salt water fish processing workers
    Mohamed F Jeebhay
    Occupational and Environmental Health Research Unit, School of Public Health and Family Medicine, University of Cape Town, Western Cape, South Africa
    Am J Ind Med 51:899-910. 2008
    ..The aim of this study was to determine the prevalence and host determinants of allergic symptoms, allergic sensitization, bronchial hyper-responsiveness and asthma among workers processing saltwater fish...
  57. doi request reprint Global lung health: the colliding epidemics of tuberculosis, tobacco smoking, HIV and COPD
    R N van Zyl Smit
    Lung Infection and Immunity Unit, Division of Pulmonology and UCT Lung Institute, Dept of Medicine, University of Cape Town, Cape Town, South Africa
    Eur Respir J 35:27-33. 2010
    ..These interactions deserve urgent attention and have major implications for coordinated public health planning and policy recommendations in the developing world...
  58. ncbi request reprint Keeping allergy on the agenda: integrated guidelines for respiratory disease in developing countries
    R G English
    The University of Cape Town Lung Institute, Mowbray, Cape Town, South Africa
    Allergy 62:224-9. 2007
    ..Innovative approaches are required to ensure that these diseases are not neglected...
  59. ncbi request reprint The Practical Approach to Lung Health in South Africa (PALSA) intervention: respiratory guideline implementation for nurse trainers
    A Bheekie
    School of Pharmacy, Discipline of Pharmacology, University of the Western Cape, Cape Town, South Africa
    Int Nurs Rev 53:261-8. 2006
    ..PALSA combines evidence-based syndromic guidelines on the management of respiratory disease in adults with group educational outreach to nurse practitioners...
  60. ncbi request reprint An evaluation of symptom and chest radiographic screening in tuberculosis prevalence surveys
    S den Boon
    Desmond Tutu TB Centre, Faculty of Health Sciences, Stellenbosch University, Cape Town, South Africa
    Int J Tuberc Lung Dis 10:876-82. 2006
    ..The population was 36,334 in 2001, and the TB notification rate was 341 per 100,000 population for new smear-positive TB in 2002...
  61. pmc Immunomodulation with recombinant interferon-gamma1b in pulmonary tuberculosis
    Rod Dawson
    Division of Pulmonology, Department of Medicine, Health Sciences Faculty, University of Cape Town, Cape Town, South Africa
    PLoS ONE 4:e6984. 2009
    ..Immune adjuvant therapy with recombinant interferon-gamma1b (rIFN-gammab) may reduce pulmonary inflammation and reduce the period of infectivity by promoting earlier sputum clearance...
  62. pmc Chest radiograph reading and recording system: evaluation for tuberculosis screening in patients with advanced HIV
    R Dawson
    University of Cape Town Lung Institute, Division of Pulmonology and E16 Respiratory Clinic, Groote Schuur Hospital, Cape Town, South Africa
    Int J Tuberc Lung Dis 14:52-8. 2010
    ..An antiretroviral treatment (ART) service in Gugulethu township, Cape Town, South Africa...
  63. ncbi request reprint Changes in fatal and near-fatal asthma in an urban area of South Africa from 1980-1997
    H J Zar
    Dept of Pediatrics and Child Health, University of Cape Town, South Africa
    Eur Respir J 18:33-7. 2001
    ..However, the relatively high asthma mortality rate in people of mixed race and the predominance of deaths outside health facilities and on weekends suggest problems with access to care...
  64. pmc Association between smoking and tuberculosis infection: a population survey in a high tuberculosis incidence area
    S den Boon
    Centre for TB Research and Education, Department of Paediatrics and Child Health, Stellenbosch University, P O Box 19063, 7505 Tygerberg, Cape Town, South Africa
    Thorax 60:555-7. 2005
    ..The aim of this study was to determine the association between smoking and M tuberculosis infection...
  65. ncbi request reprint Socioeconomic deprivation and asthma prevalence and severity in young adolescents
    M A Poyser
    Dept of Environmental and Geographical Sciences, University of Cape Town, South Africa
    Eur Respir J 19:892-8. 2002
    ..The impact of social mobility on asthma, including reporting of symptoms, deserves closer study...
  66. doi request reprint Determinants of asthma phenotypes in supermarket bakery workers
    R Baatjies
    Centre for Occupational and Environmental Health Research Unit, School of Public Health and Family Medicine, University of Cape Town, Cape Town, South Africa
    Eur Respir J 34:825-33. 2009
    ..4, 2.0-19.8). OA is the most common phenotype among supermarket bakery workers. Analysis of risk factors contributes to defining clinical phenotypes, which will guide ongoing medical surveillance and clinical management of bakery workers...
  67. ncbi request reprint Development and evaluation of a new chest radiograph reading and recording system for epidemiological surveys of tuberculosis and lung disease
    S den Boon
    Department of Paediatrics and Child Health, Faculty of Health Sciences, Desmond Tutu TB Centre, Stellenbosch University, Cape Town, South Africa
    Int J Tuberc Lung Dis 9:1088-96. 2005
    ..The development and evaluation of a new chest radiograph reading and recording system (CRRS) for community surveys of tuberculosis (TB) and lung disease...
  68. ncbi request reprint The association of prolonged breastfeeding and allergic disease in poor urban children
    C C Obihara
    Centre for TB Research and Education, Dept of Paediatrics and Child Health, Faculty of Health Sciences, Stellenbosch University, PO Box 19063, South Africa
    Eur Respir J 25:970-7. 2005
    ..This protective effect was not found in children with an allergic predisposition...
  69. doi request reprint A 4-year trial of tiotropium in chronic obstructive pulmonary disease
    Donald P Tashkin
    David Geffen School of Medicine at the University of California, Los Angeles 90095 1690, USA
    N Engl J Med 359:1543-54. 2008
    ..Previous studies showing that tiotropium improves multiple end points in patients with chronic obstructive pulmonary disease (COPD) led us to examine the long-term effects of tiotropium therapy...