Gita Ramjee

Summary

Affiliation: Medical Research Council
Country: South Africa

Publications

  1. ncbi request reprint The impact of incident and prevalent herpes simplex virus-2 infection on the incidence of HIV-1 infection among commercial sex workers in South Africa
    Gita Ramjee
    HIV 1 Prevention Research Unit, Medical Research Council, Durban, South Africa
    J Acquir Immune Defic Syndr 39:333-9. 2005
  2. pmc Microbicides 2006 conference
    Gita Ramjee
    HIV Prevention Research Unit, Medical Research Council, Durban, South Africa
    AIDS Res Ther 3:25. 2006
  3. pmc Microbicides 2008 conference: from discovery to advocacy
    Gita Ramjee
    HIV Prevention Research Unit, Medical Research Council, Durban, South Africa
    AIDS Res Ther 5:19. 2008
  4. pmc The diaphragm and lubricant gel for prevention of cervical sexually transmitted infections: results of a randomized controlled trial
    Gita Ramjee
    Medical Research Council, Durban, South Africa
    PLoS ONE 3:e3488. 2008
  5. ncbi request reprint The value of site preparedness studies for future implementation of phase 2/IIb/III HIV prevention trials: experience from the HPTN 055 study
    Gita Ramjee
    HIV Prevention Research Unit, Medical Research Council, Overport, Durban, South Africa
    J Acquir Immune Defic Syndr 47:93-100. 2008
  6. pmc South Africa's experience of the closure of the cellulose sulphate microbicide trial
    Gita Ramjee
    HIV Prevention Research Unit, Medical Research Council, Durban, KwaZulu Natal, South Africa
    PLoS Med 4:e235. 2007
  7. ncbi request reprint Prevalence of HIV among truck drivers visiting sex workers in KwaZulu-Natal, South Africa
    Gita Ramjee
    HIV Prevention and Vaccine Research Division, Medical Research Council, Durban, South Africa
    Sex Transm Dis 29:44-9. 2002
  8. pmc Geographical clustering of high risk sexual behaviors in "hot-spots" for HIV and sexually transmitted infections in Kwazulu-Natal, South Africa
    Gita Ramjee
    HIV Prevention Research Unit, Medical Research Council, 123 Jan Hofmeyr Road, Westville, Durban, South Africa
    AIDS Behav 18:317-22. 2014
  9. pmc HIV incidence among non-pregnant women living in selected rural, semi-rural and urban areas in KwaZulu-Natal, South Africa
    Gita Ramjee
    HIV Prevention Research Unit, Medical Research Council, 123 Jan Hofmeyr Road, Westville, Durban 3630, South Africa
    AIDS Behav 16:2062-71. 2012
  10. pmc High risk sexual behaviors are associated with sexual violence among a cohort of women in Durban, South Africa
    Zakir Gaffoor
    HIV Prevention Research Unit, Medical Research Council, Durban, South Africa
    BMC Res Notes 6:532. 2013

Collaborators

Detail Information

Publications49

  1. ncbi request reprint The impact of incident and prevalent herpes simplex virus-2 infection on the incidence of HIV-1 infection among commercial sex workers in South Africa
    Gita Ramjee
    HIV 1 Prevention Research Unit, Medical Research Council, Durban, South Africa
    J Acquir Immune Defic Syndr 39:333-9. 2005
    ..Drawing on other recent studies these data suggest that incident HSV-2 infection increases the risk of HIV-1 infection; the effect wanes with time since infection; and the effect is significantly greater for men than it is for women...
  2. pmc Microbicides 2006 conference
    Gita Ramjee
    HIV Prevention Research Unit, Medical Research Council, Durban, South Africa
    AIDS Res Ther 3:25. 2006
    ..This report discusses the current status of microbicide research and development, encompassing basic and clinical science, social and behavioural science, and community mobilisation and advocacy activities...
  3. pmc Microbicides 2008 conference: from discovery to advocacy
    Gita Ramjee
    HIV Prevention Research Unit, Medical Research Council, Durban, South Africa
    AIDS Res Ther 5:19. 2008
    ....
  4. pmc The diaphragm and lubricant gel for prevention of cervical sexually transmitted infections: results of a randomized controlled trial
    Gita Ramjee
    Medical Research Council, Durban, South Africa
    PLoS ONE 3:e3488. 2008
    ....
  5. ncbi request reprint The value of site preparedness studies for future implementation of phase 2/IIb/III HIV prevention trials: experience from the HPTN 055 study
    Gita Ramjee
    HIV Prevention Research Unit, Medical Research Council, Overport, Durban, South Africa
    J Acquir Immune Defic Syndr 47:93-100. 2008
    ..To evaluate the preparedness for phase 2/IIb/III microbicide trials at 4 clinical trial sites: Durban and Hlabisa (South Africa), Lusaka (Zambia), and Moshi (Tanzania)...
  6. pmc South Africa's experience of the closure of the cellulose sulphate microbicide trial
    Gita Ramjee
    HIV Prevention Research Unit, Medical Research Council, Durban, KwaZulu Natal, South Africa
    PLoS Med 4:e235. 2007
  7. ncbi request reprint Prevalence of HIV among truck drivers visiting sex workers in KwaZulu-Natal, South Africa
    Gita Ramjee
    HIV Prevention and Vaccine Research Division, Medical Research Council, Durban, South Africa
    Sex Transm Dis 29:44-9. 2002
    ..Although the role of mobile populations in the spread of HIV has been documented in several countries, there are few data on HIV among truck drivers in South Africa and the sex workers with whom they interact...
  8. pmc Geographical clustering of high risk sexual behaviors in "hot-spots" for HIV and sexually transmitted infections in Kwazulu-Natal, South Africa
    Gita Ramjee
    HIV Prevention Research Unit, Medical Research Council, 123 Jan Hofmeyr Road, Westville, Durban, South Africa
    AIDS Behav 18:317-22. 2014
    ....
  9. pmc HIV incidence among non-pregnant women living in selected rural, semi-rural and urban areas in KwaZulu-Natal, South Africa
    Gita Ramjee
    HIV Prevention Research Unit, Medical Research Council, 123 Jan Hofmeyr Road, Westville, Durban 3630, South Africa
    AIDS Behav 16:2062-71. 2012
    ..The epidemic in KwaZulu-Natal calls for targeted HIV prevention interventions among those at highest risk of acquiring or transmitting infection...
  10. pmc High risk sexual behaviors are associated with sexual violence among a cohort of women in Durban, South Africa
    Zakir Gaffoor
    HIV Prevention Research Unit, Medical Research Council, Durban, South Africa
    BMC Res Notes 6:532. 2013
    ..This study describes the prevalence of Forced Sex (FS) experiences of women who enrolled into an HIV biomedical intervention study, and its association with risky sexual behaviour...
  11. pmc Population-level impact of hormonal contraception on incidence of HIV infection and pregnancy in women in Durban, South Africa
    Gita Ramjee
    HIV Prevention Research Unit, Medical Research Council, 123 Jan Hofmeyr Road, Westville, Durban, 3630, South Africa
    Bull World Health Organ 90:748-55. 2012
    ..To estimate the potential impact of using hormonal contraceptives on rates of infection with human immunodeficiency virus type 1 (HIV-1) and pregnancy by theoretically removing the use of hormonal contraceptives from a study population...
  12. ncbi request reprint Incidence of Sexually Transmitted Infections among HIV-positive sex workers in KwaZulu-Natal, South Africa
    Catherine A Connolly
    Biostatistics Unit, Medical Research Council, Durban, South Africa
    Sex Transm Dis 29:721-4. 2002
    ..However, the success of such programs among HIV-positive sex workers has not been shown. GOAL The goal of the study was to determine the incidence of STIs ( and infections) among HIV-positive sex workers...
  13. pmc Experiences in conducting multiple community-based HIV prevention trials among women in KwaZulu-Natal, South Africa
    Gita Ramjee
    HIV Prevention Research Unit, South African Medical Research Council, 123 Jan Hofmeyr Road, Westville, 3630, Durban, South Africa
    AIDS Res Ther 7:10. 2010
    ....
  14. pmc A developing country response to Lavery et al. "In global health research, is it legitimate to stop clinical trials early on account of their opportunity costs?"
    Douglas R Wassenaar
    Biomedical Research Ethics Committee, University of KwaZulu Natal, Durban, South Africa
    BMC Med Ethics 10:16. 2009
    ..A recent paper presents an argument and mechanism for the possible stopping of clinical trials early based on opportunity costs...
  15. doi request reprint Novel strategies implemented to ensure high participant retention rates in a community based HIV prevention effectiveness trial in South Africa and Zimbabwe
    Sharika Gappoo
    HIV Prevention Research Unit, Medical Research Council, South Africa
    Contemp Clin Trials 30:411-8. 2009
    ....
  16. pmc Predictors of perceived male partner concurrency among women at risk for HIV and STI acquisition in Durban, South Africa
    Zakir Gaffoor
    HIV Prevention Research Unit, South African Medical Research Council, Durban, South Africa
    AIDS Res Ther 13:14. 2016
    ..The aim of this study was to identify predictors of perceived male partner concurrency among sexually active, HIV negative women...
  17. pmc Sharing of Investigational Drug Among Participants in the Voice Trial
    Jeeva Moodley
    HIV Prevention Research Unit, South African Medical Research Council, 123 Jan Hofmeyr Road, Westville, Durban, 3630, South Africa
    AIDS Behav 20:2709-2714. 2016
    ..ClinicalTrials.gov number: NCT00705679...
  18. pmc Individual and Population Level Impact of Key HIV Risk Factors on HIV Incidence Rates in Durban, South Africa
    Gita Ramjee
    HIV Prevention Research Unit, Medical Research Council, Durban, South Africa
    PLoS ONE 11:e0153969. 2016
    ..Addressing these risks requires targeted structural, behavioural, biomedical and cultural interventions in order to impact on unacceptably high HIV incidence rates among young women and the population as a whole. ..
  19. pmc Prevalence of Herpes Simplex Virus 2 (HSV-2) infection and associated risk factors in a cohort of HIV negative women in Durban, South Africa
    Brodie Daniels
    HIV Prevention Research Unit, Medical Research Council, Durban, South Africa
    BMC Res Notes 9:510. 2016
    ..Univariate and multivariate logistic and Cox regression models were used to determine the correlates and predictors of HSV-2 infection at enrolment and seroconversion during the study respectively...
  20. pmc Biological factors that place women at risk for HIV: evidence from a large-scale clinical trial in Durban
    Nathlee Samantha Abbai
    HIV Prevention Research Unit, Medical Research Council, 123 Jan Hofmeyr Road, Westville, Durban, 3630, South Africa
    BMC Womens Health 16:19. 2016
    ..We hypothesize that in this cohort of women, a higher rate of HIV seroconversions will be observed for women who present with evidence of mucosal damage...
  21. doi request reprint Contraception use and impact on pregnancy prevention in women participating in an HIV prevention trial in South Africa
    Jayajothi Moodley
    Senior Scientist, HIV Prevention Research Unit, South African Medical Research Council, Durban, South Africa
    J Fam Plann Reprod Health Care 42:5-11. 2016
    ..This study describes contraception use and its impact on pregnancy in women participating in HIV prevention research and its implications for public health practice...
  22. pmc Microbicides for HIV prevention
    Gita Ramjee
    Medical Research Council, Durban, South Africa
    Indian J Med Res 134:930-8. 2011
    ....
  23. doi request reprint Microbicide research: current and future directions
    Gita Ramjee
    HIV Prevention Research Unit, Medical Research Council, Durban, South Africa
    Curr Opin HIV AIDS 5:316-21. 2010
    ..This review takes into consideration clinical, basic scientific and behavioural research published on microbicides in the past 12-18 months...
  24. pmc Women and HIV in Sub-Saharan Africa
    Gita Ramjee
    HIV Prevention Research Unit, South African Medical Research Council, 123 Jan Hofmeyr Road, Westville, Durban 3629, South Africa
    AIDS Res Ther 10:30. 2013
    ....
  25. pmc Randomised controlled trial testing the effect of cotrimoxazole prophylaxis on morbidity and mortality outcomes in breastfed HIV-exposed uninfected infants: study protocol
    Anna Coutsoudis
    Department of Paediatrics and Child Health, University of KwaZulu Natal, Durban, South Africa
    BMJ Open 6:e010656. 2016
    ..The absence of proven benefits in HEU breastfed infants associated with infectious diseases justifies an RCT as proposed. Herewith lies the rationale for conducting the proposed study...
  26. pmc Use of a Vaginal Ring Containing Dapivirine for HIV-1 Prevention in Women
    Jared M Baeten
    From the Departments of Global Health J M B, B A R, p n, Medicine J M B, Epidemiology J M B, M H, and Biostatistics E R B, B A R, University of Washington, and the Statistical Center for HIV AIDS Research and Prevention, Fred Hutchinson Cancer Research Center E R B, M H, B A R, J B, K P, D W S both in Seattle Wits Reproductive Health and HIV Institute, University of the Witwatersrand, Johannesburg T P P, HIV Prevention Research Unit, South African Medical Research Council V G, S S, N J, z g, A P, L N, G R, and Center for AIDS Programme of Research in South Africa G N, Durban, and the Desmond Tutu HIV Center, University of Cape Town, Cape Town L G B all in South Africa FHI 360, Durham, NC K S, A M
    N Engl J Med . 2016
    ..Funded by the National Institutes of Health; ClinicalTrials.gov number, NCT01617096 .)...
  27. doi request reprint The generational effect on age disparate partnerships and the risk for human immunodeficiency virus and sexually transmitted infections acquisition
    Renée A Street
    HIV Prevention Research Unit, South African Medical Research Council, Durban, South Africa
    Int J STD AIDS 27:746-52. 2016
    ..Reduction of multiple partnerships remains key to HIV prevention; however, in light of partner concurrency being more prevalent than individual concurrency partnerships, female-initiated HIV prevention options remain critical. ..
  28. pmc Perceptions of vaginal microbicides as an HIV prevention method among health care providers in KwaZulu-Natal, South Africa
    Gita Ramjee
    South African Medical Research Council, HIV Prevention Research Unit, 123 Jan Hofmeyer Road, Westville, 3630, Durban, South Africa
    AIDS Res Ther 4:7. 2007
    ....
  29. pmc Acceptability of Carraguard, a candidate microbicide and methyl cellulose placebo vaginal gels among HIV-positive women and men in Durban, South Africa
    Gita Ramjee
    Medical Research Council, P O Box 70380, Overport, 4067, KwaZulu Natal, South Africa
    AIDS Res Ther 4:20. 2007
    ..Gel use questions were applicable to participants in the gel arms only (13 sexually abstinent women, 14 sexually active women, and 13 abstinent men)...
  30. pmc Age-Disparate Partnerships and Risk of HIV-1 Acquisition Among South African Women Participating in the VOICE Trial
    Jennifer E Balkus
    Vaccine and Infectious Disease Division, Fred Hutchinson Cancer Research Center Seattle, WA Department of Global Health, University of Washington Seattle, WA CAPRISA University of KwaZulu Natal, Durban, South Africa RTI International, San Francisco, CA Department of Biostatistics, University of Washington Seattle, WA University of Witwatersrand, Johannesburg, South Africa South African Medical Research Council, Durban, South Africa Perinatal HIV Research Unit, Chris Hani Baragwanath Hospital, Johannesburg, South Africa The Aurum Institute, Klerksdorp, South Africa UZ UCSF, Harare, Zimbabwe and Department of Medicine, University of Washington, Seattle, WA
    J Acquir Immune Defic Syndr 70:212-7. 2015
    ..92; 95% confidence interval: 0.49 to 1.74) was not associated with HIV-1 acquisition. These data corroborate recent reports and may suggest a shift in local epidemiology of heterosexual HIV-1 transmission. ..
  31. pmc Socio-demographic and behavioural characteristics associated with HSV-2 sero-prevalence in high risk women in KwaZulu-Natal
    Nathlee Samantha Abbai
    HIV Prevention Research Unit, Medical Research Council, 123 Jan Hofmeyr Road, Westville, Durban, 3630, South Africa
    BMC Res Notes 8:185. 2015
    ..HSV-2 serum antibodies were detected using HerpeSelect™ ELISA IgG. Statistical analysis was performed using STATA release 12.0. This study was registered with ClinicalTrials.gov,number NCT00121459 on the 28th February 2007...
  32. doi request reprint Shared responsibility for ensuring appropriate management of incidental findings: a case study from South Africa
    Yukteshwar Sookrajh
    HIV Prevention Research Unit, South African Medical Research Council, Durban, South Africa
    J Med Ethics 41:281-3. 2015
    ..This case illustrates the complexities in the management of incidental findings within the context of clinical trials and highlights the importance of ethical oversight of trials...
  33. doi request reprint The last decade of microbicide clinical trials in Africa: from hypothesis to facts
    Gita Ramjee
    HIV Prevention Research Unit, Medical Research Council, Durban, South Africa
    AIDS 24:S40-9. 2010
    ..PrEP for vaginal administration in various formulations is being tested to continue our commitment to providing more HIV prevention options to millions of women worldwide...
  34. pmc "We have our protector": misperceptions of protection against HIV among participants in a microbicide efficacy trial
    Joanne E Mantell
    MSPH, HIV Center for Clinical and Behavioral Studies, New York State Psychiatric Institute, Columbia University, New York, NY, USA
    Am J Public Health 96:1073-7. 2006
    ..We examined perceptions of the effectiveness and acceptability of a candidate microbicide among 94 South African female sex workers who had participated in a phase 3 microbicide trial for HIV prevention...
  35. pmc Diaphragm and lubricant gel for prevention of HIV acquisition in southern African women: a randomised controlled trial
    Nancy S Padian
    University of California, San Francisco, CA, USA
    Lancet 370:251-61. 2007
    ..We assessed the effect of provision of latex diaphragm, lubricant gel, and condoms (intervention), compared with condoms alone (control) on HIV seroincidence in women in South Africa and Zimbabwe...
  36. pmc Regional clustering of shared neutralization determinants on primary isolates of clade C human immunodeficiency virus type 1 from South Africa
    Renata Bures
    Department of Surgery, Duke University Medical Center, Durham, NC 27710, USA
    J Virol 76:2233-44. 2002
    ..The clustering of shared neutralization determinants on clade C primary HIV-1 isolates from South Africa suggests that neutralizing antibodies induced by vaccines will have less epitope diversity to overcome at a regional level...
  37. ncbi request reprint Effectiveness of COL-1492, a nonoxynol-9 vaginal gel, on HIV-1 transmission in female sex workers: a randomised controlled trial
    Lut Van Damme
    Institute of Tropical Medicine, Antwerp, Belgium
    Lancet 360:971-7. 2002
    ..Results of studies of its effectiveness in prevention of HIV-1 infection in women have been inconclusive. We aimed to assess effectiveness of this vaginal gel...
  38. ncbi request reprint Response to Brown et al., 'Incident and prevalent herpes simplex virus type 2 infection increases risk of HIV acquisition among women in Uganda and Zimbabwe'
    Brian G Williams
    AIDS 21:2356-7. 2007
  39. doi request reprint Lack of effectiveness of cellulose sulfate gel for the prevention of vaginal HIV transmission
    Lut Van Damme
    CONRAD, Arlington, VA, USA
    N Engl J Med 359:463-72. 2008
    ..Women make up more than 50% of adults living with human immunodeficiency virus (HIV) infection or the acquired immunodeficiency syndrome (AIDS) in sub-Saharan Africa. Thus, female-initiated HIV prevention methods are urgently needed...
  40. ncbi request reprint Microbicide acceptability research: current approaches and future directions
    Joanne E Mantell
    HIV Center for Clinical and Behavioral Studies, at the New York State Psychiatric Institute and Columbia University, 1051 Riverside Drive, Unit 15, New York, NY 10032, USA
    Soc Sci Med 60:319-30. 2005
    ..Failure to understand the key factors associated with microbicide acceptability is likely to hinder the adoption and continued use of products that are effective in preventing HIV infection...
  41. ncbi request reprint Heterosexual transmission of multiple highly conserved viral variants in HIV-1 subtype C-infected seronegative women
    Cecilia Rademeyer
    Institute of Infectious Diseases and Molecular Medicine, Division of Medical Virology, University of Cape Town, Observatory 7925, Cape Town, South Africa
    AIDS 18:2096-8. 2004
    ..11% for p17p24, 0.32% for C2C3). In two individuals diversity was uncharacteristically lower in env C2C3 than in gag pl7p24, suggesting selection in env at this very early stage of infection...
  42. ncbi request reprint Nonoxynol-9 spermicide for prevention of vaginally acquired HIV and other sexually transmitted infections: systematic review and meta-analysis of randomised controlled trials including more than 5000 women
    David Wilkinson
    Division of Health Sciences, University of South Australia, Adelaide, Australia
    Lancet Infect Dis 2:613-7. 2002
    ..There is some evidence of harm through genital lesions. N-9 cannot be recommended for HIV and STI prevention...
  43. ncbi request reprint Incidence of HIV-1 dual infection and its association with increased viral load set point in a cohort of HIV-1 subtype C-infected female sex workers
    Jandre Grobler
    Institute for Infectious Diseases and Molecular Medicine, Division of Medical Virology, University of Cape Town, Observatory, South Africa
    J Infect Dis 190:1355-9. 2004
    ..There was a significant association between dual infection and elevated viral load set point...
  44. ncbi request reprint The impact of the use of COL-1492, a nonoxynol-9 vaginal gel, on the presence of cervical human papillomavirus in female sex workers
    Dianne Marais
    Institute of Infectious Disease and Molecular Medicine, Faculty of Health Sciences, University of Cape Town, Observatory, Cape Town, South Africa
    Virus Res 121:220-2. 2006
    ..5 95% CI 1.0-11.8). We conclude that the use of nonoxynol-9 did not prevent genital HPV infection and could increase the virus' ability to infect or persist...
  45. ncbi request reprint Longitudinal analysis of HIV type 1 subtype C envelope sequences from South Africa
    Mia Coetzer
    AIDS Virus Research Unit, National Institute for Communicable Diseases, Sandringham 2131, Johannesburg, South Africa
    AIDS Res Hum Retroviruses 23:316-21. 2007
    ..In both cases this coreceptor switch was associated with specific amino acid changes in the crown, an increased net amino acid charge in the V3 loop, and an increase in the length of the V1 region...
  46. ncbi request reprint Carraguard Vaginal Gel Safety in HIV-Positive Women and Men in South Africa
    Janneke H H M van de Wijgert
    Population Council, New York, NY, USA
    J Acquir Immune Defic Syndr 46:538-46. 2007
    ..To assess the safety of the candidate microbicide Carraguard gel in HIV-positive women and men...
  47. doi request reprint Microbicide acceptability: insights for future directions from providers and policy makers
    Susie Hoffman
    HIV Center for Clinical and Behavioral Studies, New York State Psychiatric Institute, New York, NY 10032, USA
    AIDS Educ Prev 20:188-202. 2008
    ..Developing these approaches will maximize the positive influence that providers can exert on user acceptability of microbicides once they become available...
  48. doi request reprint Provision of antiretroviral therapy in South Africa: unique challenges and remaining obstacles
    Bisola Ojikutu
    Division of AIDS, Harvard Medical School, Boston, Massachusetts 02215, USA
    J Infect Dis 196:S523-7. 2007
    ....
  49. ncbi request reprint Characterization and selection of HIV-1 subtype C isolates for use in vaccine development
    Carolyn Williamson
    Division of Medical Virology, University of Cape Town, Observatory, Cape Town, South Africa 7925
    AIDS Res Hum Retroviruses 19:133-44. 2003
    ..Genes identified in this study have been incorporated into the VEE VRP candidate vaccines targeted for clinical trial in South Africa...