Tien Yin Wong

Summary

Country: Singapore

Publications

  1. pmc Cardio-metabolic risk factors and prehypertension in persons without diabetes, hypertension, and cardiovascular disease
    Peggy P C Chiang
    Singapore Eye Research Institute, Singapore National Eye Centre, Level 6, 11 Third Hospital Avenue, Singapore 168751, Singapore
    BMC Public Health 13:730. 2013
  2. pmc Intraocular pressure rise is predictive of vision improvement after intravitreal triamcinolone acetonide for diabetic macular oedema: a retrospective analysis of data from a randomised controlled trial
    Roderick F O'Day
    Clinical Ophthalmology and Eye Health, The University of Sydney, Sydney, Australia
    BMC Ophthalmol 14:123. 2014
  3. pmc A survey on computer aided diagnosis for ocular diseases
    Zhuo Zhang
    Institute for Infocomm Research, 1 Fusionopolis Way, Singapore, Singapore
    BMC Med Inform Decis Mak 14:80. 2014
  4. pmc Combined genotype and haplotype tests for region-based association studies
    Sergii Zakharov
    Human Genetics, Genome Institute of Singapore, Singapore, Singapore
    BMC Genomics 14:569. 2013
  5. pmc Update on animal models of diabetic retinopathy: from molecular approaches to mice and higher mammals
    Remya Robinson
    Singapore Eye Research Institute, Singapore
    Dis Model Mech 5:444-56. 2012
  6. pmc Genetic loci for retinal arteriolar microcirculation
    Xueling Sim
    Center for Statistical Genetics, University of Michigan, Ann Arbor, Michigan, United States of America
    PLoS ONE 8:e65804. 2013
  7. pmc Ethnic differences in the association between blood pressure components and chronic kidney disease in middle aged and older Asian adults
    Charumathi Sabanayagam
    Singapore Eye Research Institute, 11 Third Hospital Avenue 06 13, SNEC Bldg, Singapore, Singapore
    BMC Nephrol 14:86. 2013
  8. ncbi request reprint Traditional and novel risk factors of diabetic retinopathy and research challenges
    Gavin S Tan
    Singapore Eye Research Institute, Singapore
    Curr Med Chem 20:3189-99. 2013
  9. doi request reprint Prevalence of and racial differences in pterygium: a multiethnic population study in Asians
    Marcus Ang
    Singapore Eye Research Institute, Singapore National Eye Centre, Singapore, Republic of Singapore
    Ophthalmology 119:1509-15. 2012
  10. doi request reprint Fenofibrate - a potential systemic treatment for diabetic retinopathy?
    Tien Yin Wong
    Singapore Eye Research Institute, National University of Singapore, Singapore
    Am J Ophthalmol 154:6-12. 2012

Collaborators

Detail Information

Publications98

  1. pmc Cardio-metabolic risk factors and prehypertension in persons without diabetes, hypertension, and cardiovascular disease
    Peggy P C Chiang
    Singapore Eye Research Institute, Singapore National Eye Centre, Level 6, 11 Third Hospital Avenue, Singapore 168751, Singapore
    BMC Public Health 13:730. 2013
    ..Prehypertension has been shown to be an early risk factor of cardiovascular disease (CVD). We investigated the prevalence and pattern of cardiometabolic risk factors in prehypertension in three ethnic Asian populations in Singapore...
  2. pmc Intraocular pressure rise is predictive of vision improvement after intravitreal triamcinolone acetonide for diabetic macular oedema: a retrospective analysis of data from a randomised controlled trial
    Roderick F O'Day
    Clinical Ophthalmology and Eye Health, The University of Sydney, Sydney, Australia
    BMC Ophthalmol 14:123. 2014
    ..We evaluated whether there is a correlation between the development of intraocular pressure rise and improvement in vision...
  3. pmc A survey on computer aided diagnosis for ocular diseases
    Zhuo Zhang
    Institute for Infocomm Research, 1 Fusionopolis Way, Singapore, Singapore
    BMC Med Inform Decis Mak 14:80. 2014
    ..It not only alleviates the burden on the clinicians by providing objective opinion with valuable insights, but also offers early detection and easy access for patients...
  4. pmc Combined genotype and haplotype tests for region-based association studies
    Sergii Zakharov
    Human Genetics, Genome Institute of Singapore, Singapore, Singapore
    BMC Genomics 14:569. 2013
    ..Both high quality haplotypes and genotypes may be available for analysis given the development of next generation sequencing technologies and haplotype assembly algorithms...
  5. pmc Update on animal models of diabetic retinopathy: from molecular approaches to mice and higher mammals
    Remya Robinson
    Singapore Eye Research Institute, Singapore
    Dis Model Mech 5:444-56. 2012
    ....
  6. pmc Genetic loci for retinal arteriolar microcirculation
    Xueling Sim
    Center for Statistical Genetics, University of Michigan, Ann Arbor, Michigan, United States of America
    PLoS ONE 8:e65804. 2013
    ..In conclusion, we found one novel loci which underlie genetic variation in microvasculature which may be relevant to vascular disease. The relevance of these findings to clinical outcomes remains to be determined...
  7. pmc Ethnic differences in the association between blood pressure components and chronic kidney disease in middle aged and older Asian adults
    Charumathi Sabanayagam
    Singapore Eye Research Institute, 11 Third Hospital Avenue 06 13, SNEC Bldg, Singapore, Singapore
    BMC Nephrol 14:86. 2013
    ..However, it is not clear if there are ethnic differences in this association. We examined the association between BP and CKD in a multi-ethnic Asian population in Singapore...
  8. ncbi request reprint Traditional and novel risk factors of diabetic retinopathy and research challenges
    Gavin S Tan
    Singapore Eye Research Institute, Singapore
    Curr Med Chem 20:3189-99. 2013
    ..Research into new markers for retinopathy including genetics, blood biomarkers and retinal imaging will further improve our understanding of the risk factors and pathogenesis of diabetic retinopathy. ..
  9. doi request reprint Prevalence of and racial differences in pterygium: a multiethnic population study in Asians
    Marcus Ang
    Singapore Eye Research Institute, Singapore National Eye Centre, Singapore, Republic of Singapore
    Ophthalmology 119:1509-15. 2012
    ..To describe the prevalence and risk factors of pterygium in a multiethnic Asian population and to examine racial differences...
  10. doi request reprint Fenofibrate - a potential systemic treatment for diabetic retinopathy?
    Tien Yin Wong
    Singapore Eye Research Institute, National University of Singapore, Singapore
    Am J Ophthalmol 154:6-12. 2012
    ..To review clinical and experimental data for fenofibrate as a possible systemic treatment for diabetic retinopathy...
  11. doi request reprint Differential associations of myopia with major age-related eye diseases: the Singapore Indian Eye Study
    Chen Wei Pan
    Saw Swee Hock School of Public Health, National University of Singapore, Singapore
    Ophthalmology 120:284-91. 2013
    ..To determine the associations of myopia and axial length (AL) with major age-related eye diseases, including age-related macular degeneration (AMD), diabetic retinopathy (DR), age-related cataract, and primary open-angle glaucoma (POAG)...
  12. doi request reprint Visual impairment, age-related eye diseases, and cognitive function: the Singapore Malay Eye study
    Shin Yeu Ong
    Singapore Eye Research Institute, Singapore National Eye Centre, Singapore
    Arch Ophthalmol 130:895-900. 2012
    ..To describe the associations of visual impairment and major age-related eye diseases with cognitive function in an older Asian population...
  13. doi request reprint Retinal vascular tortuosity, blood pressure, and cardiovascular risk factors
    Carol Yim Lui Cheung
    Singapore Eye Research Institute, Singapore National Eye Centre, Singapore
    Ophthalmology 118:812-8. 2011
    ..To examine the relationship of retinal vascular tortuosity to age, blood pressure, and other cardiovascular risk factors...
  14. doi request reprint The relationship of body fatness indices and retinal vascular caliber in children
    Ling Jun Li
    Department of Epidemiology and Public Health, Yong Loo Lin School of Medicine, National University of Singapore, Singapore
    Int J Pediatr Obes 6:267-74. 2011
    ..To examine the association between body fatness indices and retinal vascular calibre in Singapore Chinese children...
  15. doi request reprint Are myopic eyes less likely to have diabetic retinopathy?
    Laurence Shen Lim
    Singapore Eye Research Institute, Singapore National Eye Centre, Singapore, Republic of Singapore
    Ophthalmology 117:524-30. 2010
    ..Eyes with myopia may be less likely to develop diabetic retinopathy (DR). The relationship between refractive error, ocular biometry, and DR therefore was investigated...
  16. doi request reprint Smoking, socioeconomic factors, and age-related cataract: The Singapore Malay Eye study
    Renyi Wu
    Singapore Eye Research Institute, Singapore
    Arch Ophthalmol 128:1029-35. 2010
    ..To describe the relationship of smoking, sex, and socioeconomic factors with age-related cataract in Malay adults in Singapore...
  17. pmc Prevalence of refractive error in Singaporean Chinese children: the strabismus, amblyopia, and refractive error in young Singaporean Children (STARS) study
    Mohamed Dirani
    Singapore Eye Research Institute, Singapore
    Invest Ophthalmol Vis Sci 51:1348-55. 2010
    ..To determine the prevalence of refractive error types in Singaporean Chinese children aged 6 to 72 months...
  18. doi request reprint Myopia, axial length, and age-related cataract: the Singapore Malay eye study
    Chen Wei Pan
    Singapore Eye Research Institute, Singapore
    Invest Ophthalmol Vis Sci 54:4498-502. 2013
    ..To describe the associations of myopia and axial length (AL) with age-related cataract in an Asian population in Singapore...
  19. doi request reprint Association of narrow angles with anterior chamber area and volume measured with anterior-segment optical coherence tomography
    Ren Yi Wu
    Singapore National Eye Centre, 11 Third Hospital Ave, Singapore 168751
    Arch Ophthalmol 129:569-74. 2011
    ..To describe the measurement of anterior chamber area and anterior chamber volume by anterior-segment optical coherence tomography and to investigate the association of these parameters with the presence of narrow angles...
  20. doi request reprint Prevalence and risk factors for age-related macular degeneration in Indians: a comparative study in Singapore and India
    Chui Ming Gemmy Cheung
    Singapore Eye Research Institute, Singapore National Eye Centre, Singapore
    Am J Ophthalmol 155:764-73, 773.e1-3. 2013
    ..To compare the prevalence and risk factors for age-related macular degeneration (AMD) in 2 Indian populations, 1 living in urban Singapore and 1 in rural central India...
  21. doi request reprint Myopia and cognitive dysfunction: the singapore malay eye study
    Shin Yeu Ong
    Singapore Eye Research Institute, Singapore National Eye Centre, Singapore
    Invest Ophthalmol Vis Sci 54:799-803. 2013
    ..To investigate a possible relationship between refractive error and cognitive function...
  22. doi request reprint Corneal arcus is a sign of cardiovascular disease, even in low-risk persons
    Marcus Ang
    Singapore Eye Research Institute, Singapore National Eye Centre, Singapore, Republic of Singapore
    Am J Ophthalmol 152:864-71.e1. 2011
    ..To examine the association of corneal arcus to cardiovascular disease (CVD) in an adult, ethnic Indian population...
  23. doi request reprint Distribution and determinants of ocular biometric parameters in an Asian population: the Singapore Malay eye study
    Laurence Shen Lim
    Singapore Eye Research Institute, Singapore National Eye Centre, Singapore
    Invest Ophthalmol Vis Sci 51:103-9. 2010
    ..To examine the distribution and systemic determinants of ocular biometry as measured using partial laser interferometry in an adult Asian population...
  24. doi request reprint Evidence of retinal vascular narrowing in glaucomatous eyes in an Asian population
    Nishani Amerasinghe
    Singapore National Eye Centre, Singapore
    Invest Ophthalmol Vis Sci 49:5397-402. 2008
    ..To examine the relationship between retinal vascular caliber and glaucoma in an Asian population...
  25. pmc Are C-reactive protein associated genetic variants associated with serum levels and retinal markers of microvascular pathology in Asian populations from Singapore?
    Rajkumar Dorajoo
    Genome Institute of Singapore, Agency for Science, Technology and Research, Singapore, Singapore
    PLoS ONE 8:e67650. 2013
    ..C-reactive protein (CRP) levels are associated with cardiovascular disease and systemic inflammation. We assessed whether CRP-associated loci were associated with serum CRP and retinal markers of microvascular disease, in Asian populations...
  26. doi request reprint Familial correlation of retinal vascular caliber in Singapore Chinese
    Ling Jun Li
    Singapore Eye Research Institute, Singapore National Eye Centre, Singapore
    Invest Ophthalmol Vis Sci 54:5638-42. 2013
    ..Our study aimed to explore the heritability of retinal vascular caliber among Singapore Chinese families...
  27. doi request reprint Racial differences in retinal vessel geometric characteristics: a multiethnic study in healthy Asians
    Xiang Li
    Singapore Eye Research Institute, Singapore
    Invest Ophthalmol Vis Sci 54:3650-6. 2013
    ..To investigate potential racial/ethnic differences in retinal vascular geometric parameters in a multiethnic Asian population (Chinese, Malay, and Indian) free of clinical diseases...
  28. pmc Genome-wide meta-analysis of five Asian cohorts identifies PDGFRA as a susceptibility locus for corneal astigmatism
    Qiao Fan
    School of Public Health, National University of Singapore, Singapore, Singapore
    PLoS Genet 7:e1002402. 2011
    ..This highlights the potential role of variants in PDGFRA in the genetic etiology of corneal astigmatism across diverse Asian populations...
  29. doi request reprint Influence of refractive error on optic disc topographic parameters: the singapore malay eye study
    Ren Yi Wu
    Singapore Eye Research Institute and Singapore National Eye Center, Singapore, Republic of Singapore
    Am J Ophthalmol 152:81-6. 2011
    ..To examine the relationship between refractive error and optic disc topographic parameters and retinal nerve fiber layer (RNFL) thickness...
  30. ncbi request reprint Myopia, axial length, and OCT characteristics of the macula in Singaporean children
    Hai Dong Luo
    Singapore Eye Research Institute, and Department of Community, Occupational and Family Medicine, National University of Singapore, Republic of Singapore
    Invest Ophthalmol Vis Sci 47:2773-81. 2006
    ..The purpose of this study was to evaluate the associations between macular volume and thickness, as assessed by optic coherence tomography (OCT), with refraction and axial length (AL) in children...
  31. doi request reprint Lack of association between primary angle-closure glaucoma susceptibility loci and the ocular biometric parameters anterior chamber depth and axial length
    Monisha E Nongpiur
    Singapore Eye Research Institute, Singapore
    Invest Ophthalmol Vis Sci 54:5824-8. 2013
    ..The purpose of this study was to investigate the associations of these loci with the ocular biometric parameters anterior chamber depth (ACD) and axial length (AL)...
  32. doi request reprint Determinants of angle closure in older Singaporeans
    Raghavan Lavanya
    Department of Glaucoma, Singapore National Eye Center and Eye Research Institute, 11 Third Hospital Ave, Singapore 168751
    Arch Ophthalmol 126:686-91. 2008
    ..To investigate systemic and ocular risk factors for angle closure (AC) in older Singaporeans and to determine if these risk factors are different in men vs women and in Chinese vs non-Chinese persons...
  33. doi request reprint Structural changes in the retinal microvasculature and renal function
    Laurence Shen Lim
    Singapore Eye Research Institute, Singapore National Eye Centre, Singapore
    Invest Ophthalmol Vis Sci 54:2970-6. 2013
    ..To evaluate the associations between chronic kidney disease (CKD) and microalbuminuria, and a comprehensive range of retinal microvascular abnormalities including traditional and new retinal vascular measures...
  34. doi request reprint Branch retinal vein occlusion and optic nerve head topographic parameters: the Singapore Indian eye study
    Errol Wei en Chan
    Department of Ophthalmology, National University Hospital, National University Health System, Singapore, Singapore
    Br J Ophthalmol 97:611-6. 2013
    ..To examine the association between branch retinal vein occlusion (BRVO) and quantitative optic disc topographic parameters...
  35. pmc Retinal vascular geometry in Asian persons with diabetes and retinopathy
    Carol Yim Lui Cheung
    Singapore Eye Research Institute, Singapore National Eye Centre, Singapore
    J Diabetes Sci Technol 6:595-605. 2012
    ..Our purpose was to examine the relationship of retinal vascular parameters with diabetes and retinopathy in an older Asian population...
  36. ncbi request reprint Effect of maternal body mass index on the retinal microvasculature in pregnancy
    Ling Jun Li
    Saw Swee Hock School of Public Health, Children s Medical Institute, and Department of Obstetrics and Gynecology, National University of Singapore, Singapore
    Obstet Gynecol 120:627-35. 2012
    ..To estimate the effects of maternal body mass index (BMI) and pregnancy weight gain on the retinal microvasculature among pregnant women...
  37. doi request reprint Retinal vascular fractal dimension and its relationship with cardiovascular and ocular risk factors
    Carol Y Cheung
    Singapore Eye Research Institute, Singapore National Eye Centre, Singapore
    Am J Ophthalmol 154:663-674.e1. 2012
    ..To examine the influence of a range of cardiovascular risk factors and ocular conditions on retinal vascular fractal dimension in the Singapore Malay Eye Study...
  38. doi request reprint Literacy is an independent risk factor for vision impairment and poor visual functioning
    Yingfeng Zheng
    Singapore Eye Research Institute, Singapore National Eye Centre, Singapore
    Invest Ophthalmol Vis Sci 52:7634-9. 2011
    ..The authors therefore investigated the independent contribution of limited literacy on visual impairment and visual function in a large eye survey in Singapore...
  39. pmc FTO variants are associated with obesity in the Chinese and Malay populations in Singapore
    Jonathan T Tan
    Center for Molecular Epidemiology, National University of Singapore, Singapore, Singapore
    Diabetes 57:2851-7. 2008
    ..The aim of this study was to examine the effects of FTO variants on obesity and type 2 diabetes in Southeast Asian populations...
  40. doi request reprint Blood pressure and retinal microvascular characteristics during pregnancy: Growing Up in Singapore Towards Healthy Outcomes (GUSTO) Study
    Ling Jun Li
    Saw Swee Hock School of Public Health, National University of Singapore, Singapore
    Hypertension 60:223-30. 2012
    ..Elevated blood pressure is associated with a range of retinal arteriolar changes in pregnant women, providing evidence for an impact of blood pressure on the microcirculation during pregnancy...
  41. doi request reprint C-reactive protein, body mass index, and diabetic retinopathy
    Laurence Shen Lim
    Singapore Eye Research Institute, Singapore National Eye Centre, Singapore
    Invest Ophthalmol Vis Sci 51:4458-63. 2010
    ..The purpose of this study was to determine the relationship between CRP, BMI, and existing DR...
  42. doi request reprint Relationship of ocular biometry and retinal vascular caliber in preschoolers
    Ling Jun Li
    Department of Epidemiology and Public Health, Yong Loo Lin School of Medicine, National University of Singapore, Singapore
    Invest Ophthalmol Vis Sci 52:9561-6. 2011
    ..To systematically examine the association between ocular biometry and retinal vascular caliber in Singapore Chinese preschoolers aged 48 to 72 months...
  43. doi request reprint Performance of the Moorfields motion displacement test for identifying eyes with glaucoma
    Ee Lin Ong
    Singapore National Eye Center and Singapore Eye Research Institute, Singapore, Republic of Singapore
    Ophthalmology 121:88-92. 2014
    ..This study evaluated the diagnostic performance of the MMDT for discriminating between healthy eyes and eyes with glaucoma...
  44. doi request reprint Measurement of macular fractal dimension using a computer-assisted program
    George N Thomas
    Singapore Eye Research Institute, Singapore National Eye Center, Singapore
    Invest Ophthalmol Vis Sci 55:2237-43. 2014
    ....
  45. pmc Automatic glaucoma diagnosis through medical imaging informatics
    Jiang Liu
    Department of Ocular Imaging, Institute for Infocomm Research, Singapore, Singapore
    J Am Med Inform Assoc 20:1021-7. 2013
    ..Glaucoma is the leading irreversible cause of blindness. Due to the lack of an effective and standard screening practice, more than 50% of the cases are undiagnosed, which prevents the early treatment of the disease...
  46. doi request reprint The prevalence and types of glaucoma in an urban Indian population: the Singapore Indian Eye Study
    Arun Narayanaswamy
    Singapore Eye Research Institute, Singapore National Eye Centre, Singapore
    Invest Ophthalmol Vis Sci 54:4621-7. 2013
    ..To determine the prevalence and types of glaucoma in an urban Singaporean Indian population...
  47. doi request reprint Serum cystatin C and prediabetes in non-obese US adults
    Charumathi Sabanayagam
    Office of Clinical Sciences, Duke NUS Graduate Medical School, Singapore, Singapore
    Eur J Epidemiol 28:311-6. 2013
    ..1) or by race-ethnicity (p = 0.6). Our findings suggest that elevated levels of serum cystatin C are associated with prediabetes in a nationally representative sample of non-obese US adults...
  48. doi request reprint Retinal vascular geometry and glaucoma: the Singapore Malay Eye Study
    Renyi Wu
    Singapore Eye Research Institute, Singapore National Eye Centre, Singapore
    Ophthalmology 120:77-83. 2013
    ..To determine the associations of geometric measurements (tortuosity, branching angle, and fractal dimension) of retinal vessels with glaucoma...
  49. doi request reprint Anterior chamber dimensions and posterior corneal arc length in Malay eyes: an anterior segment optical coherence tomography study
    Deborah K L Tan
    Singapore National Eye Centre, 11 Third Hospital Avenue, Singapore
    Invest Ophthalmol Vis Sci 53:4860-7. 2012
    ..We provided normative data of corneal and anterior segment dimensions, and a novel parameter, posterior corneal arc length (PCAL), in an adult Malay population...
  50. doi request reprint Relationship of retinal vascular tortuosity with the neuroretinal rim: the singapore malay eye study
    Victor Koh
    Singapore Eye Research Institute, Singapore National Eye Center, Singapore
    Invest Ophthalmol Vis Sci 51:3736-41. 2010
    ..Straighter retinal vessels were significantly associated with a thinning neuroretinal rim. These findings may provide additional insights into the geometric retinal vascular changes seen in early glaucomatous optic neuropathy...
  51. doi request reprint Retinal vessel caliber and peripheral neuropathy in diabetic participants
    Charumathi Sabanayagam
    Department of Ophthalmology, Yong Loo Lin School of Medicine, National University of Singapore, Singapore
    Microcirculation 17:297-302. 2010
    ..Retinal vascular caliber changes predict diabetic microvascular complications such as retinopathy, and nephropathy. However, the association between retinal vasculature and peripheral neuropathy is not well studied...
  52. doi request reprint C-reactive protein and age-related macular degeneration and cataract: the singapore malay eye study
    Pui Yi Boey
    Singapore Eye Research Institute, Singapore National Eye Centre, Singapore
    Invest Ophthalmol Vis Sci 51:1880-5. 2010
    ..In persons without diabetes, higher CRP was associated with AMD. These data suggest only a weak link between systemic inflammation and AMD and cataract in Asian people...
  53. doi request reprint Prevalence of diabetes mellitus, glycemic control, and associated factors in a Malay population in Singapore
    Charumathi Sabanayagam
    Department of Community, Occupational, and Family Medicine, Yong Loo Lin School of Medicine, National University of Singapore, Singapore
    Asia Pac J Public Health 21:385-98. 2009
    ..Nearly 1 in 5 middle-aged Malay adults living in a developed Asian society had diabetes mellitus and a substantial proportion had suboptimal glycemic control...
  54. doi request reprint The association between socioeconomic status and overweight/obesity in a Malay population in Singapore
    Charumathi Sabanayagam
    Department of Community, Occupational, and Family Medicine, Yong Loo Lin School of Medicine, National University of Singapore, Singapore
    Asia Pac J Public Health 21:487-96. 2009
    ..05 for all SES variables). Lower SES was positively associated with overweight/obesity in Malay women, and the association was in the opposite direction in Malay men...
  55. doi request reprint Retinal arteriolar wall signs and early age-related macular degeneration: the singapore malay eye study
    Chui Ming Gemmy Cheung
    Singapore National Eye Centre, Singapore
    Am J Ophthalmol 152:108-113.e1. 2011
    ..To determine whether retinal arteriolar wall signs are associated with early age-related macular degeneration (AMD)...
  56. doi request reprint The impact of cataract, cataract types, and cataract grades on vision-specific functioning using Rasch analysis
    Merwyn Chew
    Singapore Eye Research Institute, Singapore National Eye Centre, Singapore, Republic of Singapore
    Am J Ophthalmol 154:29-38.e2. 2012
    ..To determine the impact of cataracts and their types and grades on vision-specific functioning...
  57. doi request reprint Differential association of retinal arteriolar and venular caliber with diabetes and retinopathy
    Andrew S H Tsai
    Singapore Eye Research Institute, Singapore National Eye Centre, 11 Third Hospital Avenue, Singapore 168751, Singapore
    Diabetes Res Clin Pract 94:291-8. 2011
    ..To describe the relationship of retinal arteriolar and venular caliber with diabetes, retinopathy and hyperglycemia, in an Asian Indian population...
  58. doi request reprint Influence of blood pressure on retinal vascular caliber in young children
    Ling Jun Li
    Department of Epidemiology and Public Health, National University of Singapore, Singapore, Republic of Singapore
    Ophthalmology 118:1459-65. 2011
    ..This study aimed to examine the association between BP and retinal vascular caliber in Singapore Chinese preschoolers 4 to 5 years of age...
  59. pmc Prevalence of cataract surgery and visual outcomes in Indian immigrants in Singapore: the Singapore Indian eye study
    Preeti Gupta
    Singapore Eye Research Institute and Singapore National Eye Centre, Singapore, Singapore
    PLoS ONE 8:e75584. 2013
    ..To determine the prevalence of cataract surgery and factors associated with post-surgical visual outcomes in migrant Indians living in Singapore...
  60. doi request reprint Relationship between retinal vascular geometry with retinal nerve fiber layer and ganglion cell-inner plexiform layer in nonglaucomatous eyes
    Yih Chung Tham
    Singapore Eye Research Institute, Singapore National Eye Centre, Singapore
    Invest Ophthalmol Vis Sci 54:7309-16. 2013
    ..To examine the relationship between retinal vascular geometric parameters with retinal nerve fiber layer (RNFL) and ganglion cell-inner plexiform layer (GC-IPL) parameters in nonglaucomatous subjects...
  61. doi request reprint Prevalence and risk factors for refractive errors in Indians: the Singapore Indian Eye Study (SINDI)
    Chen Wei Pan
    Department of Epidemiology and Public Health, Yong Loo Lin School of Medicine, National University of Singapore, Singapore
    Invest Ophthalmol Vis Sci 52:3166-73. 2011
    ..To determine the prevalence and risk factors for refractive errors in middle-aged to elderly Singaporeans of Indian ethnicity...
  62. doi request reprint Cataract conversion assessment using lens opacity classification system III and Wisconsin cataract grading system
    Wan Ling Wong
    Singapore Eye Research Institute, Singapore National Eye Centre, Singapore
    Invest Ophthalmol Vis Sci 54:280-7. 2013
    ..To propose a general conversion approximation algorithm and illustrate its application to two cataract classification systems, the Lens Opacity Classification System III (LOCS III) and Wisconsin Cataract Grading System (Wisconsin system)...
  63. doi request reprint Prevalence and risk factors of meibomian gland dysfunction: the Singapore Malay eye study
    Jay J K Siak
    Singapore Eye Research Institute, Singapore National Eye Centre, Singapore
    Cornea 31:1223-8. 2012
    ..To describe the prevalence and associations of meibomian gland dysfunction (MGD) in an urban Malay population in Singapore...
  64. doi request reprint A new method to measure peripheral retinal vascular caliber over an extended area
    Carol Yim Lui Cheung
    Singapore Eye Research Institute, Yong Loo Lin School of Medicine, National University of Singapore, Singapore
    Microcirculation 17:495-503. 2010
    ..To describe a new computer-assisted method to measure retinal vascular caliber over an extended area of the fundus...
  65. doi request reprint Retinal microvascular caliber and chronic kidney disease in an Asian population
    Charumathi Sabanayagam
    Department of Community, Occupational, and Family Medicine, Yong Loo Lin School of Medicine, National University of Singapore, Singapore
    Am J Epidemiol 169:625-32. 2009
    ..Retinal venular diameter was not associated with chronic kidney disease. These data suggest that retinal arteriolar narrowing is associated with chronic kidney disease, independent of diabetes and hypertension...
  66. doi request reprint Variation in prevalence of myopia between generations of migrant indians living in Singapore
    Chen Wei Pan
    School of Public Health, National University of Singapore, Singapore
    Am J Ophthalmol 154:376-381.e1. 2012
    ..To assess the influence of factors related to migration and acculturation on myopia in migrant Indians in Singapore...
  67. doi request reprint Corneal biomechanical properties and retinal vascular caliber in children
    Laurence Lim
    Singapore Eye Research Institute, Singapore
    Invest Ophthalmol Vis Sci 50:121-5. 2009
    ..To examine the relationship between corneal biomechanical properties and retinal vascular caliber in Singaporean children in a cross-sectional study of 257 healthy subjects from the Singapore Cohort Study of Risk Factors for Myopia...
  68. doi request reprint Cardiovascular risk factors, inflammation, and corneal arcus: the singapore malay eye study
    Renyi Wu
    Singapore Eye Research Institute, Singapore National Eye Centre, Singapore
    Am J Ophthalmol 150:581-587.e1. 2010
    ..To examine the relationship of corneal arcus with cardiovascular risk factors and inflammation in Malay adults living in Singapore...
  69. doi request reprint Ethnic disparities in prevalence and impact of risk factors of chronic kidney disease
    Charumathi Sabanayagam
    Department of Ophthalmology, Yong Loo Lin School of Medicine, National University of Singapore, Kent Ridge, Singapore
    Nephrol Dial Transplant 25:2564-70. 2010
    ..We aimed to assess the prevalence and risk factors of CKD in a multi-ethnic Asian population in Singapore...
  70. doi request reprint Ocular component growth curves among Singaporean children with different refractive error status
    Hwee Bee Wong
    Health Services Research and Evaluation Division, Ministry of Health, Singapore, Republic of Singapore
    Invest Ophthalmol Vis Sci 51:1341-7. 2010
    ..To describe and compare ocular component growth curves among different refractive error groups in Singaporean children...
  71. doi request reprint Influence of refractive error and axial length on retinal vessel geometric characteristics
    Laurence Shen Lim
    Singapore Eye Research Institute, Singapore National Eye Centre, Singapore
    Invest Ophthalmol Vis Sci 52:669-78. 2011
    ..To evaluate the influence of refractive error and axial length (AL) on retinal vascular network geometry measurements in an adult Asian population...
  72. doi request reprint Anterior segment optical coherence tomography study of the cornea and anterior segment in adult ethnic South Asian Indian eyes
    Marcus Ang
    Singapore National Eye Centre, Singapore
    Invest Ophthalmol Vis Sci 53:120-5. 2012
    ..To report normative results of anterior segment and corneal biometric parameters and their associations in ethnic South Asian Indian adults...
  73. doi request reprint Lens vault, thickness, and position in Chinese subjects with angle closure
    Monisha E Nongpiur
    Singapore Eye Research Institute and Singapore National Eye Center, Singapore, Republic of Singapore
    Ophthalmology 118:474-9. 2011
    ..To investigate the association of lens parameters-specifically, lens vault (LV), lens thickness (LT), and lens position (LP)-with angle closure...
  74. doi request reprint The impact of bilateral or unilateral cataract surgery on visual functioning: when does second eye cataract surgery benefit patients?
    Anna C S Tan
    Singapore Eye Research Institute, Singapore National Eye Centre, Singapore, Singapore
    Br J Ophthalmol 96:846-51. 2012
    ..To examine the impact of bilateral or unilateral cataract surgery on visual functioning...
  75. ncbi request reprint A cohort study of incident myopia in Singaporean children
    Seang Mei Saw
    Department of Community, Occupational, and Family Medicine, National University of Singapore, Singapore
    Invest Ophthalmol Vis Sci 47:1839-44. 2006
    ..To determine the risk factors of incident myopia in a school-based cohort study in Singaporean children...
  76. doi request reprint Argon laser with and without anti-vascular endothelial growth factor therapy for extrafoveal polypoidal choroidal vasculopathy
    Chui Ming Gemmy Cheung
    Singapore National Eye Centre, Singapore, Republic of Singapore
    Am J Ophthalmol 155:295-304.e1. 2013
    ..To describe the clinical characteristics and outcome of eyes with extrafoveal polypoidal choroidal vasculopathy (PCV) treated with argon laser...
  77. pmc Early retinal arteriolar changes and peripheral neuropathy in diabetes
    Jie Ding
    Singapore Eye Research Institute, Singapore National Eye Centre, Singapore
    Diabetes Care 35:1098-104. 2012
    ..To examine the association between early retinal arteriolar abnormalities and diabetic peripheral neuropathy (DPN)...
  78. doi request reprint Effect of corneal arcus on central corneal thickness, intraocular pressure, and primary open-angle glaucoma: the Singapore Malay Eye Study
    Renyi Wu
    Singapore Eye Research Institute, Singapore
    Arch Ophthalmol 128:1455-61. 2010
    ..To examine the association of corneal arcus with central corneal thickness (CCT), intraocular pressure (IOP), and the prevalence of primary open-angle glaucoma...
  79. doi request reprint SgD-CNV, a database for common and rare copy number variants in three Asian populations
    Haiyan Xu
    Centre for Molecular Epidemiology, National University of Singapore, Singapore
    Hum Mutat 32:1341-9. 2011
    ..We also report noticeable population differentiation in the CNV landscape of these Asian populations, with the greatest diversity seen between the Indians and the Chinese...
  80. pmc A statistical method for region-based meta-analysis of genome-wide association studies in genetically diverse populations
    Xu Wang
    Department of Epidemiology and Public Health, National University of Singapore, Singapore
    Eur J Hum Genet 20:469-75. 2012
    ....
  81. doi request reprint Variation of angle parameters in asians: an anterior segment optical coherence tomography study in a population of singapore malays
    Nishani Amerasinghe
    Singapore National Eye Centre, Singapore
    Invest Ophthalmol Vis Sci 50:2626-31. 2009
    ..To assess variations in angle parameters using anterior segment optical coherence tomography (AS-OCT) and to investigate demographic, ocular and systemic associations of angle width...
  82. doi request reprint Validity of a new computer-aided diagnosis imaging program to quantify nuclear cataract from slit-lamp photographs
    Carol Yim Lui Cheung
    Singapore Eye Research Institute, Singapore
    Invest Ophthalmol Vis Sci 52:1314-9. 2011
    ..To validate a new computer-aided diagnosis (CAD) imaging program for the assessment of nuclear lens opacity...
  83. doi request reprint C-reactive protein and retinal microvascular caliber in a multiethnic asian population
    Carol Yim-Lui Cheung
    Singapore Eye Research Institute, 11 Third Hospital Avenue, Singapore, Singapore
    Am J Epidemiol 171:206-13. 2010
    ....
  84. doi request reprint Association of variants in FRAP1 and PDGFRA with corneal curvature in Asian populations from Singapore
    Siyu Han
    Department of Statistics and Applied Probability, National University of Singapore, Blk S16, 6 Science Drive 2, 117546, Singapore
    Hum Mol Genet 20:3693-8. 2011
    ..This is the first genome-wide survey of CC variation and we have identified two implicated loci in three genetically diverse Asian populations, suggesting the presence of common genetic etiology across multiple populations...
  85. doi request reprint Retinal microvasculature as a model to study the manifestations of hypertension
    Carol Yim Lui Cheung
    Singapore Eye Research Institute, 11 Third Hospital Ave, Singapore 168751, Singapore
    Hypertension 60:1094-103. 2012
    ....
  86. doi request reprint Retinal vascular calibre as a predictor of incidence and progression of diabetic retinopathy
    Jie Ding
    Singapore Eye Research Institute, Singapore National Eye Centre, Singapore
    Clin Exp Optom 95:290-6. 2012
    ....
  87. doi request reprint Peripheral refraction and refractive error in singapore chinese children
    Chelvin C A Sng
    Singapore Eye Research Institute, Singapore
    Invest Ophthalmol Vis Sci 52:1181-90. 2011
    ..Peripheral hyperopia was hypothesized to stimulate axial elongation. This study describes peripheral refraction and its associations with central refractive error in young Singapore Chinese children...
  88. pmc Transferability of type 2 diabetes implicated loci in multi-ethnic cohorts from Southeast Asia
    Xueling Sim
    Centre for Molecular Epidemiology, National University of Singapore, Singapore, Singapore
    PLoS Genet 7:e1001363. 2011
    ..These findings highlight the value of surveying across diverse racial/ethnic groups towards the fine-mapping efforts for the casual variants and also of the search for variants, which may be population-specific...
  89. doi request reprint Polymorphisms identified through genome-wide association studies and their associations with type 2 diabetes in Chinese, Malays, and Asian-Indians in Singapore
    Jonathan T Tan
    Department of Epidemiology and Public Health, Yong Loo Lin School of Medicine, National University of Singapore, Singapore
    J Clin Endocrinol Metab 95:390-7. 2010
    ..However, the association in other East Asian populations is less well characterized...
  90. pmc Natural positive selection and north-south genetic diversity in East Asia
    Chen Suo
    Centre for Molecular Epidemiology, National University of Singapore, Singapore, Singapore
    Eur J Hum Genet 20:102-10. 2012
    ..This has important implications to autoimmune studies that plan to impute the classical HLA alleles to fine map the SNP association signals...
  91. pmc Genetic variants on chromosome 1q41 influence ocular axial length and high myopia
    Qiao Fan
    Saw Swee Hock School of Public Health, National University of Singapore, Singapore, Singapore
    PLoS Genet 8:e1002753. 2012
    ..This supports the likely role of genetic variants at chromosome 1q41 in influencing AL variation and high myopia...
  92. doi request reprint Is there a clear threshold for fasting plasma glucose that differentiates between those with and without neuropathy and chronic kidney disease?: the Singapore Prospective Study Program
    Ei Ei Khaing Nang
    Department of Community, Occupational and Family Medicine, Yong Loo Lin School of Medicine, National University of Singapore, Singapore
    Am J Epidemiol 169:1454-62. 2009
    ..Ascertaining these individuals may require development and application of novel screening strategies...
  93. ncbi request reprint Retinal microvascular abnormalities and 10-year cardiovascular mortality: a population-based case-control study
    Tien Yin Wong
    Singapore National Eye Center and National University of Singapore, Singapore, Republic of Singapore
    Ophthalmology 110:933-40. 2003
    ..Retinal microvascular abnormalities reflect persistent arteriolar damage from hypertension and independently predict stroke. We examined their associations with long-term cardiovascular mortality...
  94. doi request reprint Testability of vision and refraction in preschoolers: the strabismus, amblyopia, and refractive error study in singaporean children
    Michelle J Trager
    Department of Community, Occupational and Family Medicine, National University of Singapore, Singapore, Republic of Singapore
    Am J Ophthalmol 148:235-241.e6. 2009
    ..To determine the testability of several vision and refraction tests in preschool-aged children...
  95. doi request reprint Current epidemiology of diabetic retinopathy and diabetic macular edema
    Jie Ding
    Singapore Eye Research Institute, Singapore National Eye Centre, Singapore
    Curr Diab Rep 12:346-54. 2012
    ..Future research is necessary to better understand the potential role of other risk factors such as apolipoproteins and genetic predisposition to shape public health programs...
  96. doi request reprint Relation of age-related cataract with obesity and obesity genes in an Asian population
    Laurence S Lim
    Singapore Eye Research Institute, Singapore
    Am J Epidemiol 169:1267-74. 2009
    ..30, 95% CI: 1.08, 1.55). These results do not support a causal association between obesity and cortical or PSC cataract. The FTO gene may be involved in the pathogenesis of nuclear cataract...
  97. doi request reprint Breast-feeding and overweight in Singapore school children
    Charumathi Sabanayagam
    Department of Community, Occupational, and Family Medicine, Yong Loo Lin School of Medicine, National University of Singapore, Singapore
    Pediatr Int 51:650-6. 2009
    ..Few data are available from Asian populations. The purpose of the present study was therefore to evaluate the association between breast-feeding and overweight/obesity in a study of 10-12-year-old children in Singapore...
  98. doi request reprint Visual impairment and its impact on health-related quality of life in adolescents
    Hwee Bee Wong
    Health Services Research and Evaluation Division, Ministry of Health, Singapore, Republic of Singapore
    Am J Ophthalmol 147:505-511.e1. 2009
    ..To determine the impact of visual impairment on health-related quality of life (QoL) measures in adolescents...