David Chien Lye

Summary

Affiliation: Tan Tock Seng Hospital
Country: Singapore

Publications

  1. ncbi request reprint Review of human infections with avian influenza H5N1 and proposed local clinical management guideline
    David C B Lye
    Department of Infectious Diseases, Tan Tock Seng Hospital, Singapore
    Ann Acad Med Singapore 36:285-92. 2007
  2. ncbi request reprint Cluster of Staphylococcus aureus and dengue co-infection in Singapore
    Louis Y A Chai
    Department of Infectious Diseases, Tan Tock Seng Hospital, Singapore
    Ann Acad Med Singapore 36:847-50. 2007
  3. ncbi request reprint Ertapenem for treatment of extended-spectrum beta-lactamase-producing and multidrug-resistant gram-negative bacteraemia
    David Chien Lye
    Department of Infectious Diseases, Tan Tock Seng Hospital, Singapore
    Ann Acad Med Singapore 37:831-4. 2008
  4. pmc Oral versus intravenous antibiotics for patients with Klebsiella pneumoniae liver abscess: study protocol for a randomized controlled trial
    James Molton
    Division of Infectious Diseases, University Medicine Cluster, National University Health System, Singapore, Singapore
    Trials 14:364. 2013
  5. pmc Vancomycin versus daptomycin for the treatment of methicillin-resistant Staphylococcus aureus bacteremia due to isolates with high vancomycin minimum inhibitory concentrations: study protocol for a phase IIB randomized controlled trial
    Shirin Kalimuddin
    Department of Infectious Diseases, Singapore General Hospital, 20 College Road, Singapore 169856, Singapore
    Trials 15:233. 2014
  6. pmc A prospective observational study of the prevalence and risk factors for colonization by antibiotic resistant bacteria in patients at admission to hospital in Singapore
    Barnaby E Young
    Institute of Infectious Diseases and Epidemiology, Communicable Diseases Centre, Singapore, Singapore
    BMC Infect Dis 14:298. 2014
  7. pmc Utility of warning signs in guiding admission and predicting severe disease in adult dengue
    Yee Sin Leo
    Department of Infectious Disease, Communicable Disease Center, Institute of Infectious Disease and Epidemiology, Tan Tock Seng Hospital, Singapore, Singapore
    BMC Infect Dis 13:498. 2013
  8. pmc Combination strategies for pandemic influenza response - a systematic review of mathematical modeling studies
    Vernon J Lee
    Center for Health Services Research, National University of Singapore, Singapore
    BMC Med 7:76. 2009
  9. pmc Confirmed adult dengue deaths in Singapore: 5-year multi-center retrospective study
    Yee Sin Leo
    Department of Infectious Diseases, Tan Tock Seng Hospital, Singapore
    BMC Infect Dis 11:123. 2011
  10. ncbi request reprint Do young adults with uncomplicated dengue fever need hospitalisation? A retrospective analysis of clinical and laboratory features
    D C Lye
    Department of Infectious Diseases, Communicable Disease Centre, Tan Tock Seng Hospital, Singapore
    Singapore Med J 49:476-9. 2008

Collaborators

  • Leo Yee Sin
  • Oon Tek Ng
  • Angela Chow
  • Li Yang Hsu
  • Adrian Ong
  • Yee Sin Leo
  • Vernon J Lee
  • Prabha Krishnan
  • Tau Hong Lee
  • Kalisvar Marimuthu
  • Barnaby Young
  • Shirin Kalimuddin
  • Barnaby E Young
  • Thuan Tong Tan
  • Rachel Phillips
  • Mihir Gandhi
  • Sophia Archuleta
  • James Molton
  • Victor C Gan
  • Monica Chan
  • Louis Y A Chai
  • Linda Kay Lee
  • Rick Twee Hee Ong
  • Yik Ying Teo
  • Wei Xin Khong
  • Eryu Xia
  • Brenda Sze Ang
  • Nurun Nisa de Souza
  • Jenny G H Low
  • Siew Pang Chan
  • Joanne Yoong
  • Chi Jong Go
  • Ying Hao
  • Lee Ching Ng
  • Kwoon Yong Pok
  • Dale Fisher
  • Ee Ling Ng
  • Frederico Dimatatac
  • Dale A Fisher
  • Helen M Oh
  • Tun L Thein
  • Rajmohan L Narayanan
  • Jenny G Low
  • Mark I Chen
  • Caroline P S Lee
  • Adriana S H Tan
  • Annelies Wilder-Smith
  • Yan Sun
  • Gina Fernandez
  • Yee Leong Teoh
  • Cheng Chuan Lee
  • Poh Lian Lim

Detail Information

Publications15

  1. ncbi request reprint Review of human infections with avian influenza H5N1 and proposed local clinical management guideline
    David C B Lye
    Department of Infectious Diseases, Tan Tock Seng Hospital, Singapore
    Ann Acad Med Singapore 36:285-92. 2007
    ..We decided to evaluate published evidence in relation to epidemiology, clinical features and course, laboratory diagnosis, treatment and outcome of human H5N1 influenza, and develop institutional clinical management guidelines...
  2. ncbi request reprint Cluster of Staphylococcus aureus and dengue co-infection in Singapore
    Louis Y A Chai
    Department of Infectious Diseases, Tan Tock Seng Hospital, Singapore
    Ann Acad Med Singapore 36:847-50. 2007
    ..Singapore saw a resurgence of dengue infections in 2005. Concurrent bacterial co-infections in dengue is rare...
  3. ncbi request reprint Ertapenem for treatment of extended-spectrum beta-lactamase-producing and multidrug-resistant gram-negative bacteraemia
    David Chien Lye
    Department of Infectious Diseases, Tan Tock Seng Hospital, Singapore
    Ann Acad Med Singapore 37:831-4. 2008
    ..Clinical efficacy of ertapenem in ESBL-producing gramnegative bacteraemia is limited...
  4. pmc Oral versus intravenous antibiotics for patients with Klebsiella pneumoniae liver abscess: study protocol for a randomized controlled trial
    James Molton
    Division of Infectious Diseases, University Medicine Cluster, National University Health System, Singapore, Singapore
    Trials 14:364. 2013
    ..Our primary aim is to compare the efficacy of early (< one week) step-down to oral antibiotics, to continuing four weeks of intravenous antibiotics, in patients with Klebsiella liver abscess...
  5. pmc Vancomycin versus daptomycin for the treatment of methicillin-resistant Staphylococcus aureus bacteremia due to isolates with high vancomycin minimum inhibitory concentrations: study protocol for a phase IIB randomized controlled trial
    Shirin Kalimuddin
    Department of Infectious Diseases, Singapore General Hospital, 20 College Road, Singapore 169856, Singapore
    Trials 15:233. 2014
    ..5 ug/ml) in terms of reducing all-cause 60-day mortality...
  6. pmc A prospective observational study of the prevalence and risk factors for colonization by antibiotic resistant bacteria in patients at admission to hospital in Singapore
    Barnaby E Young
    Institute of Infectious Diseases and Epidemiology, Communicable Diseases Centre, Singapore, Singapore
    BMC Infect Dis 14:298. 2014
    ..Drug resistant organisms pose an increasing threat to the successful treatment of common infections. Understanding colonization patterns of these bacteria is important for effective antibiotic treatment and infection control guidelines...
  7. pmc Utility of warning signs in guiding admission and predicting severe disease in adult dengue
    Yee Sin Leo
    Department of Infectious Disease, Communicable Disease Center, Institute of Infectious Disease and Epidemiology, Tan Tock Seng Hospital, Singapore, Singapore
    BMC Infect Dis 13:498. 2013
    ..We evaluated the utility of using warning signs to guide hospital admission and predict disease progression in adults...
  8. pmc Combination strategies for pandemic influenza response - a systematic review of mathematical modeling studies
    Vernon J Lee
    Center for Health Services Research, National University of Singapore, Singapore
    BMC Med 7:76. 2009
    ..Individual strategies in pandemic preparedness plans may not reduce the impact of an influenza pandemic...
  9. pmc Confirmed adult dengue deaths in Singapore: 5-year multi-center retrospective study
    Yee Sin Leo
    Department of Infectious Diseases, Tan Tock Seng Hospital, Singapore
    BMC Infect Dis 11:123. 2011
    ..A new WHO 2009 guideline emphasized warning signs and a wider range of severe dengue manifestations. We aim to evaluate the utility of these two guidelines in confirmed adult dengue fatalities...
  10. ncbi request reprint Do young adults with uncomplicated dengue fever need hospitalisation? A retrospective analysis of clinical and laboratory features
    D C Lye
    Department of Infectious Diseases, Communicable Disease Centre, Tan Tock Seng Hospital, Singapore
    Singapore Med J 49:476-9. 2008
    ..We aimed to determine if hospitalised dengue patients had significant morbidity and mortality, and if admissions were in accordance with previously-published admission criteria...
  11. doi request reprint Reactive Infection Control Strategy for Control of New Delhi Metallo-β-Lactamase (NDM)-Producing Enterobacteriaceae Analyzed Using Whole-Genome Sequencing: Hits and Misses
    Kalisvar Marimuthu
    1Department of Infectious Diseases, Institute of Infectious Diseases and Epidemiology, Tan Tock Seng Hospital, Singapore, Singapore
    Infect Control Hosp Epidemiol 37:987-90. 2016
    ..Phylogenetic analysis proved that 1 contact was a direct transmission while the other was unrelated to the index, suggesting hidden routes of transmission. Infect Control Hosp Epidemiol 2016;37:987-990. ..
  12. ncbi request reprint Current management of severe dengue infection
    Tau Hong Lee
    a Communicable Disease Centre, Institute of Infectious Diseases and Epidemiology, Tan Tock Seng Hospital, Singapore, Singapore
    Expert Rev Anti Infect Ther 15:67-78. 2017
    ..The results from phase III trials of two new candidate vaccines are eagerly awaited...
  13. pmc Derivation and validation of an accurate estimation of CD4 counts from the absolute lymphocyte count in virologically suppressed and immunologically reconstituted HIV infected adults
    Barnaby Young
    Institute of Infectious Diseases and Epidemiology, Tan Tock Seng Hospital, Singapore, Singapore
    BMC Infect Dis 15:330. 2015
    ..A simple method to estimate CD4 counts in stable, HIV infected virologically-suppressed and immune-reconstituted adults could save the expense of unnecessary formal testing...
  14. ncbi request reprint Pandemic (H1N1) 2009: clinical and laboratory findings of the first fifty cases in Singapore
    Monica Chan
    Department of Infectious Diseases, Tan Tock Seng Hospital, Singapore
    Ann Acad Med Singapore 39:267-6. 2010
    ..We describe here the clinical and laboratory characteristics of the fi rst 50 adult cases with confirmed pandemic (H1N1) 2009...
  15. doi request reprint Predictive value of simple clinical and laboratory variables for dengue hemorrhagic fever in adults
    Vernon J Lee
    Department of Clinical Epidemiology, Tan Tock Seng Hospital, Singapore
    J Clin Virol 42:34-9. 2008
    ..Singapore experienced its worst dengue outbreak in 30 years in 2004, with 9459 notified cases, of which 83% were hospitalized...