K B Chua

Summary

Affiliation: Singapore General Hospital
Country: Singapore

Publications

  1. pmc A previously unknown reovirus of bat origin is associated with an acute respiratory disease in humans
    Kaw Bing Chua
    National Public Health Laboratory, Selangor 4700, Malaysia
    Proc Natl Acad Sci U S A 104:11424-9. 2007
  2. ncbi request reprint Nipah virus encephalitis outbreak in Malaysia
    Sai Kit Lam
    Department of Medical Microbiology, Faculty of Medicine, University of Malaya, Kuala Lumpur, Malaysia
    Clin Infect Dis 34:S48-51. 2002
  3. ncbi request reprint Nipah virus outbreak in Malaysia
    Kaw Bing Chua
    International Medical University, Sesama Center, Plaza Komanwel, Bukit Jalil, Kuala Lumpur, 57000, Malaysia
    J Clin Virol 26:265-75. 2003
  4. pmc Investigation of a potential zoonotic transmission of orthoreovirus associated with acute influenza-like illness in an adult patient
    Kaw Bing Chua
    National Public Health Laboratory, Sg Buloh, Selangor, Malaysia
    PLoS ONE 6:e25434. 2011
  5. pmc Identification and characterization of a new orthoreovirus from patients with acute respiratory infections
    Kaw Bing Chua
    National Public Health Laboratory, Sg Buloh, Selangor, Malaysia
    PLoS ONE 3:e3803. 2008
  6. ncbi request reprint An outbreak of acute haemorrhagic conjunctivitis in Melaka, Malaysia
    O Ghazali
    Pejabat Kesihatan Daerah, Melaka Tengah, Melaka 75150, Malaysia
    Singapore Med J 44:511-6. 2003
  7. ncbi request reprint A new cell culture tube in diagnostic virology for virus isolation
    K B Chua
    National Public Health Laboratory, Ministry of Health Malaysia, Malaysia
    Malays J Pathol 26:69-71. 2004
  8. ncbi request reprint Seroprevalence of Malassezia furfur in an urban population in Malaysia
    Kaw Bing Chua
    International Medical University, Kuala Lumpur, Malaysia
    Malays J Pathol 25:49-56. 2003
  9. ncbi request reprint Effect of chemical fogging on immature Aedes mosquitoes in natural field conditions
    K B Chua
    International Medical University, Sesama Centre, Plaza Komanwel, 57000 Bukit Jalil, Kuala Lumpur, Malaysia
    Singapore Med J 46:639-44. 2005
  10. ncbi request reprint Differential environmental preferences of gravid female Aedes mosquitoes in ovipositing their eggs
    Kaw Bing Chua
    International Medical University, Sesama Center, Kuala Lumpur, Malaysia
    Southeast Asian J Trop Med Public Health 36:1132-8. 2005

Collaborators

Detail Information

Publications52

  1. pmc A previously unknown reovirus of bat origin is associated with an acute respiratory disease in humans
    Kaw Bing Chua
    National Public Health Laboratory, Selangor 4700, Malaysia
    Proc Natl Acad Sci U S A 104:11424-9. 2007
    ..These data indicate that bat-borne reoviruses can be transmitted to and cause clinical diseases in humans...
  2. ncbi request reprint Nipah virus encephalitis outbreak in Malaysia
    Sai Kit Lam
    Department of Medical Microbiology, Faculty of Medicine, University of Malaya, Kuala Lumpur, Malaysia
    Clin Infect Dis 34:S48-51. 2002
    ..The Island flying fox (Pteropus hypomelanus; the fruit bat) is a likely reservoir of this virus. The outbreak in Malaysia was controlled through the culling of >1 million pigs...
  3. ncbi request reprint Nipah virus outbreak in Malaysia
    Kaw Bing Chua
    International Medical University, Sesama Center, Plaza Komanwel, Bukit Jalil, Kuala Lumpur, 57000, Malaysia
    J Clin Virol 26:265-75. 2003
    ....
  4. pmc Investigation of a potential zoonotic transmission of orthoreovirus associated with acute influenza-like illness in an adult patient
    Kaw Bing Chua
    National Public Health Laboratory, Sg Buloh, Selangor, Malaysia
    PLoS ONE 6:e25434. 2011
    ....
  5. pmc Identification and characterization of a new orthoreovirus from patients with acute respiratory infections
    Kaw Bing Chua
    National Public Health Laboratory, Sg Buloh, Selangor, Malaysia
    PLoS ONE 3:e3803. 2008
    ..The discovery of Kampar virus highlights the increasing trend of emergence of bat zoonotic viruses and the need to expand our understanding of bats as a source of many unknown viruses...
  6. ncbi request reprint An outbreak of acute haemorrhagic conjunctivitis in Melaka, Malaysia
    O Ghazali
    Pejabat Kesihatan Daerah, Melaka Tengah, Melaka 75150, Malaysia
    Singapore Med J 44:511-6. 2003
    ..2%), followed by foreign body sensation (81.8%), pain (78.3%) and subconjunctival haemorrhage (74.4%). The mean duration of illness was 6.5 and five days for patients with and without subconjunctival haemorrhage respectively...
  7. ncbi request reprint A new cell culture tube in diagnostic virology for virus isolation
    K B Chua
    National Public Health Laboratory, Ministry of Health Malaysia, Malaysia
    Malays J Pathol 26:69-71. 2004
    ..It is designed to culture an initial inoculum of one milliliter of culture medium containing 1 x 10(4) to 1 x 10(5) cells/ml...
  8. ncbi request reprint Seroprevalence of Malassezia furfur in an urban population in Malaysia
    Kaw Bing Chua
    International Medical University, Kuala Lumpur, Malaysia
    Malays J Pathol 25:49-56. 2003
    ....
  9. ncbi request reprint Effect of chemical fogging on immature Aedes mosquitoes in natural field conditions
    K B Chua
    International Medical University, Sesama Centre, Plaza Komanwel, 57000 Bukit Jalil, Kuala Lumpur, Malaysia
    Singapore Med J 46:639-44. 2005
    ..Dengue and dengue haemorrhagic fever are common and serious arboviral diseases endemic in a number of countries situated in both the tropical and subtropical belts...
  10. ncbi request reprint Differential environmental preferences of gravid female Aedes mosquitoes in ovipositing their eggs
    Kaw Bing Chua
    International Medical University, Sesama Center, Kuala Lumpur, Malaysia
    Southeast Asian J Trop Med Public Health 36:1132-8. 2005
    ....
  11. ncbi request reprint Isolation of monoclonal antibodies-escape variant of dengue virus serotype 1
    S K Chua
    Hospital Tengku Ampuan Rahimah, Jalan Banting, Klang 41200, Malaysia
    Singapore Med J 47:940-6. 2006
    ..We report the associated clinical features and limited molecular genetics of this Mab-escape dengue virus variant...
  12. ncbi request reprint A modified mycological medium for isolation and culture of Malassezia furfur
    Kaw Bing Chua
    International Medical University, Kuala Lumpur, Malaysia
    Malays J Pathol 27:99-105. 2005
    ..With this medium, the conventional bacteriological procedures such as microbial streaking for pure culture and anti-microbial sensitivity testing could be carried out for these lipophilic yeasts...
  13. ncbi request reprint Genetic diversity of enterovirus 71 isolated from cases of hand, foot and mouth disease in the 1997, 2000 and 2005 outbreaks, Peninsular Malaysia
    K B Chua
    National Public Health Laboratory, Ministry of Health, Selangor, Malaysia
    Malays J Pathol 29:69-78. 2007
    ..The data suggested that the EV71 strains causing the outbreak in Sarawak could have originated from peninsular Malaysia...
  14. ncbi request reprint Negative cross-reactivity of rabbit anti-Malassezia furfur antibodies with other yeasts
    Kaw Bing Chua
    International Medical University, Kuala Lumpur
    Malays J Pathol 27:123-5. 2005
    ..Anti-M. furfur monospecific polyclonal antibodies produced in rabbit in this study has the potential for diagnostic application in immunohistochemical detection of M. furfur in human tissues...
  15. ncbi request reprint Epidemiology of chikungunya in Malaysia: 2006-2009
    K B Chua
    National Public Health Laboratory, Infectious Disease, Makmal Kesihatan Awam Kebangsaan, Kementerian Kesihatan, Lot 1853, Kg Melayu, Sungai Buloh, Selangor 47000, Malaysia
    Med J Malaysia 65:277-82. 2010
    ..Those patients in the laboratory confirmed group had a significant higher incidence of fever, arthralgia and rash than those in the epidemiological linked group...
  16. ncbi request reprint A comparative evaluation of dengue diagnostic tests based on single-acute serum samples for laboratory confirmation of acute dengue
    K B Chua
    National Public Health Laboratory, Ministry of Health, Sungai Buloh, Selangor, Malaysia
    Malays J Pathol 33:13-20. 2011
    ..Real-time RT-PCR was significantly more sensitive than the conventional RT-PCR...
  17. ncbi request reprint Epidemiology, surveillance and control of Nipah virus infections in Malaysia
    K B Chua
    Makmal Kesihatan Awam Kebangsaan National Public Health Laboratory, Ministry of Health, Selangor, Malaysia
    Malays J Pathol 32:69-73. 2010
    ....
  18. doi request reprint Hand foot and mouth disease due to enterovirus 71 in Malaysia
    Kaw Bing Chua
    National Public Health Laboratory, Ministry of Health, Lot 1853, 47000 Sungai Buloh, Selangor, Malaysia
    Virol Sin 26:221-8. 2011
    ..Epidemiological and molecular data since 1997 show the recurrence of HFMD due to EV71 in Malaysia every 2 to 4 years. In each of the past outbreaks, more than one sub-genogroup of the virus co-circulate...
  19. ncbi request reprint A fatal case of chikungunya virus infection with liver involvement
    H H Chua
    Sarawak General Hospital, Jalan Hospital, 93586 Kuching, Sarawak, Malaysia
    Med J Malaysia 65:83-4. 2010
    ..He subsequently passed away due to cardiovascular collapse after 5 days of illness...
  20. ncbi request reprint Risk factors, prevention and communication strategy during Nipah virus outbreak in Malaysia
    K B Chua
    Makmal Kesihatan Awam Kebangsaan National Public Health Laboratory, Ministry of Health, Selangor, Malaysia
    Malays J Pathol 32:75-80. 2010
    ....
  21. ncbi request reprint Broad reactive monoclonal antibodies for rapid identification of enteroviruses show cross-reactivity with chikungunya virus infected cells
    A H Khairul
    The National Public Health Laboratory, Ministry of Health of Malaysia, Sungai Buloh, Selangor, Malaysia
    Malays J Pathol 32:49-52. 2010
    ..Final identification of the virus could be determined with specific antibodies or molecular typing using specific oligonucleotide primers for the CHIK virus...
  22. ncbi request reprint Evaluating the sensitivity of a commercial dengue NS1 antigen-capture ELISA for early diagnosis of acute dengue virus infection
    V Kumarasamy
    The National Public Health Laboratory, Ministry of Health, Lot 1853 Kg Melayu, Sungai Buloh 47000, Malaysia
    Singapore Med J 48:669-73. 2007
    ..The aim of this report is to establish an accurate diagnosis of acute dengue virus infection early, in order to provide timely information for the management of patients and early public health control of dengue outbreak...
  23. ncbi request reprint The presence of Nipah virus in respiratory secretions and urine of patients during an outbreak of Nipah virus encephalitis in Malaysia
    K B Chua
    Department of Medical Microbiology, Faculty of Medicine, University of Malaya, Kuala Lumpur, Malaysia
    J Infect 42:40-3. 2001
    ..CONCLUSION: This study shows that it is possible to be infected from secretions of infected patients, but epidemiological survey on close contacts so far did not suggest that human-to-human transmission is common...
  24. ncbi request reprint Re-emergence of Chikungunya virus in Malaysia
    V Kumarasamy
    Makmal Kesihatan Awam Kebangsaan, Kementerian Kesihatan, Sungai Buloh, Selangor, Malaysia
    Med J Malaysia 61:221-5. 2006
    ..Phylogenetic analysis of the CHIK virus based on the 257 nts partial E1 gene indicates that Bagan Panchor's strain was closely related to the first CHIK virus isolated during the outbreak in Klang in 1998...
  25. ncbi request reprint Evaluation of a commercial dengue NS1 antigen-capture ELISA for laboratory diagnosis of acute dengue virus infection
    V Kumarasamy
    Makmal Kesihatan Awam Kebangsaan National Public Health Laboratory, Kementerian Kesihatan, Lot 1853 Kg Melayu, 47000 Sungai Buloh, Selangor, Malaysia
    J Virol Methods 140:75-9. 2007
    ..The results indicate that the commercial dengue NS1 antigen-capture ELISA may be superior to virus isolation and RT-PCR for the laboratory diagnosis of acute dengue infection based on a single serum sample...
  26. ncbi request reprint Epidemiological and clinical features of dengue versus other acute febrile illnesses amongst patients seen at government polyclinics
    B Mustafa
    Makmal Kesihatan Awam Kebangsaan National Public Health Laboratory, Kementerian Kesihatan, Lot 1853, Kg Melayu, 47000 Sungai Buloh, Selangor, Malaysia
    Med J Malaysia 65:291-6. 2010
    ..The finding strongly suggests that a proportion of patients in the recent dengue group may actually represent a subset of patients with acute dengue fever at the late stage of illness...
  27. ncbi request reprint Chikungunya infection--an emerging disease in Malaysia
    S K Lam
    Department of Medical Microbiology, Faculty of Medicine, University of Malaya, Kuala Lumpur, Malaysia
    Southeast Asian J Trop Med Public Health 32:447-51. 2001
    ..Malaysia is heavily dependent on migrant workers from countries where chikungunya is endemic. It is speculated that the virus has been re-introduced into the country through the movement of these workers...
  28. ncbi request reprint A comparative study on the performance of two commercial anti-dengue IgM assay kits
    V Kumarasamy
    Makmal Kesihatan Awam Kebangsaan, Kementerian Kesihatan, Lot 1853, 47000 Sungai Buloh, Selangor, Malaysia
    Med J Malaysia 62:85-6. 2007
    ....
  29. ncbi request reprint Identification of enterovirus 71 isolates from an outbreak of hand, foot and mouth disease (HFMD) with fatal cases of encephalomyelitis in Malaysia
    S AbuBakar
    Department of Medical Microbiology, University Malaya Medical Center, Kuala Lumpur, Malaysia
    Virus Res 61:1-9. 1999
    ..These findings suggest the presence of at least two potentially virulent EV71 co-circulating in Malaysia during the 1997 HFMD outbreak...
  30. ncbi request reprint Molecular phylogeny of modern coxsackievirus A16
    D Perera
    Institute of Health and Community Medicine, Universiti Malaysia Sarawak, Sarawak, Malaysia
    Arch Virol 152:1201-8. 2007
    ..4% and less than 16.3% in VP1 and VP4, respectively. Lineage 1 strains circulating before 2000 were later displaced by lineage 2 strains...
  31. ncbi request reprint Role of electron microscopy in Nipah virus outbreak investigation and control
    K B Chua
    National Public Health Laboratory, Lot 1853, 47000 Sungai Buloh, Selangor, Malaysia
    Med J Malaysia 62:139-42. 2007
    ....
  32. ncbi request reprint Isolation of measles virus from clinical specimens using B95a and Vero/hSLAM cell-lines
    C Keniscope
    Makmal Kesihatan Awam Kebangsaan National Public Health Laboratory, Kementerian Kesihatan, Lot 1853 Kg Melayu, 47000 Sungai Buloh, Selangor, Malaysia
    Med J Malaysia 64:37-40. 2009
    ..Throat swab and urine specimens are the clinical specimens of choice and both are recommended for optimal isolation of measles virus from patients suspected of acute measles virus infection...
  33. ncbi request reprint Molecular epidemiology of chikungunya virus in Malaysia since its first emergence in 1998
    Y K Chem
    National Public Health Laboratory, Ministry of Health, Lot 1853, 47000 Sungai Buloh, Selangor, Malaysia
    Med J Malaysia 65:31-5. 2010
    ..The strain that was introduced into Johor state was responsible for its subsequent spread to other parts of Malaysia, inclusive of Sarawak...
  34. ncbi request reprint Congenital rubella syndrome with positive serology and virus isolation
    H L Ooi
    Hospital Tengku Ampuan Rahimah, Klang, Selangor
    Med J Malaysia 61:248-50. 2006
    ....
  35. ncbi request reprint Differential preferences of oviposition by Aedes mosquitos in man-made containers under field conditions
    Kaw Bing Chua
    International Medical University, Sesama Center, Plaza Komanwel, Kuala Lumpur, Malaysia
    Southeast Asian J Trop Med Public Health 35:599-607. 2004
    ..However, the results of the study suggests that under favorable conditions, each gravid female Aedes mosquito could be encouraged to lay all her eggs in a single breeding site...
  36. ncbi request reprint The predictive value of uvulo-palatoglossal junctional ulcers as an early clinical sign of exanthem subitum due to human herpesvirus 6
    K B Chua
    Department of Medical Microbiology, Faculty of Medicine, University of Malaya, Kuala Lumpur, Malaysia
    J Clin Virol 17:83-90. 2000
    ..An earlier prospective clinical study showed that there was a strong association of UPJ ulcers and occurrence of ES with a positive predictive value of 95.3% and negative predictive value of 100%...
  37. ncbi request reprint Serological evidence of hantavirus infections in Malaysia
    S K Lam
    Department of Medical Microbiology, Faculty of Medicine, University of Malaya, Kuala Lumpur, Malaysia
    Southeast Asian J Trop Med Public Health 32:809-13. 2001
    ..Moreover, the data from the antibody profiles strongly suggest the presence of different hantaviruses at the study sites...
  38. ncbi request reprint An epidemiological cluster pattern of dengue outbreak amongst close contacts in Selangor, Peninsular Malaysia
    K T Ang
    Department of Health, Shah Alam, Selangor, Ministry of Health, Malaysia
    Med J Malaysia 61:292-5. 2006
    ..This epidemiological clustering pattern of acute dengue virus infection among close contacts suggests an intense rate of dengue virus transmission within the vicinity of the first deceased's house...
  39. ncbi request reprint Full length genome sequence of Tioman virus, a novel paramyxovirus in the genus Rubulavirus isolated from fruit bats in Malaysia
    K B Chua
    Department of Medical Microbiology, University of Malaya Medical Center, Kuala Lumpur, Malaysia
    Arch Virol 147:1323-48. 2002
    ....
  40. ncbi request reprint Seasonal variation in respiratory syncytial virus chest infection in the tropics
    Patrick W K Chan
    Division of Respiratory Medicine, Department of Paediatrics, University Malaya Medical Center, Kuala Lumpur, Malaysia
    Pediatr Pulmonol 34:47-51. 2002
    ..In the tropics, seasonal variations in the incidence of RSV infection are evident, with an annual peak in November, December, and January. This information provides a guide for healthcare provisions and implementation of RSV prevention...
  41. ncbi request reprint Viral aetiology of lower respiratory tract infection in young Malaysian children
    P W Chan
    Department of Paediatrics, University Malaya Medical Centre, Kuala Lumpur, Malaysia
    J Paediatr Child Health 35:287-90. 1999
    ..To study the viral aetiology of lower respiratory tract infection (LRTI) in young Malaysian children...
  42. ncbi request reprint Treatment of acute Nipah encephalitis with ribavirin
    H T Chong
    Department of Medicine, University of Malaya Medical Centre, Lembah Pantai, Kuala Lumpur, Malaysia
    Ann Neurol 49:810-3. 2001
    ..This represents a 36% reduction in mortality (p = 0.011). There was no associated serious side effect. This study suggests that ribavirin is able to reduce the mortality of acute Nipah encephalitis...
  43. ncbi request reprint Hospitalization of childhood rotavirus infection from Kuala Lumpur, Malaysia
    W S Lee
    Departments of Paediatrics, University of Malaya Medical Center, Kuala Lumpur, Malaysia
    J Paediatr Child Health 39:518-22. 2003
    ..To determine the epidemiology of rotavirus gastroenteritis in children admitted to an urban hospital in a developing country from South-East Asia...
  44. ncbi request reprint Serological evidence of possible human infection with Tioman virus, a newly described paramyxovirus of bat origin
    Koon Chu Yaiw
    Department of Pathology, University of Malaya, Kuala Lumpur, Malaysia
    J Infect Dis 196:884-6. 2007
    ..0%) were positive for T. virus, by comparative ELISA. Of these 5 sera, 3 (1.8% of the total) had neutralizing antibodies against T. virus, suggesting previous infection of this study population by this virus or a similar virus...
  45. ncbi request reprint Echovirus 7 associated encephalomyelitis
    Lucy Chai See Lum
    Department of Pediatrics, University of Malaya Medical Center, 50603, Kuala Lumpur, Malaysia
    J Clin Virol 23:153-60. 2002
    ..In 2000, an outbreak of HFMD resulted in the deaths of three children who had rapid cardio-respiratory decompensation and one child who survived a central nervous system infection...
  46. ncbi request reprint A novel approach for collecting samples from fruit bats for isolation of infectious agents
    Kaw Bing Chua
    International Medical University, Sesama Centre, Plaza Komanwel, Bukit Jalil, 57000 Kuala Lumpur, Malaysia
    Microbes Infect 5:487-90. 2003
    ..This novel approach resulted in the isolation of several other known and unidentified infectious agents besides Nipah virus...
  47. ncbi request reprint Isolation of Nipah virus from Malaysian Island flying-foxes
    Kaw Bing Chua
    Department of Medical Microbiology, Faculty of Medicine, University of Malaya, 50603 Lumpur, Kuala, Malaysia
    Microbes Infect 4:145-51. 2002
    ..The isolation of Nipah virus from the Island flying-fox corroborates the serological evidence that it is one of the natural hosts of the virus...
  48. ncbi request reprint Anthropogenic deforestation, El NiƱo and the emergence of Nipah virus in Malaysia
    Kaw Bing Chua
    Departments of Medical Microbiology, Faculty of Medicine, University of Malaya
    Malays J Pathol 24:15-21. 2002
    ..These anthropogenic events, coupled with the location of piggeries in orchards and the design of pigsties allowed transmission of a novel paramyxovirus from its reservoir host to the domestic pig and ultimately to the human population...
  49. ncbi request reprint Relapsed and late-onset Nipah encephalitis
    Chong Tin Tan
    Department of Medicine, University of Malaya, 50603 Kuala Lumpur, Malaysia
    Ann Neurol 51:703-8. 2002
    ..We concluded that a unique relapsing and remitting encephalitis or late-onset encephalitis may result as a complication of persistent Nipah virus infection in the central nervous system...
  50. pmc Nipah virus infection: pathology and pathogenesis of an emerging paramyxoviral zoonosis
    Kum Thong Wong
    University of Malaya, Kuala Lumpur, Malaysia
    Am J Pathol 161:2153-67. 2002
    ..Infection of endothelial cells and neurons as well as vasculitis and thrombosis seem to be critical to the pathogenesis of this new human disease...
  51. ncbi request reprint Tioman virus infection in experimentally infected mouse brain and its association with apoptosis
    Koon Chu Yaiw
    Department of Pathology, Faculty of Medicine, University of Malaya, 50603 Kuala Lumpur, Malaysia
    J Virol Methods 143:140-6. 2007
    ..Bcl-2 was expressed in some neurons and inflammatory cells indicating its possible role in anti-apoptosis. There was no evidence of central nervous system infection via the intraperitoneal route...
  52. pmc Membrane fusion tropism and heterotypic functional activities of the Nipah virus and Hendra virus envelope glycoproteins
    Katharine N Bossart
    Department of Microbiology and Immunology, Uniformed Services University, Bethesda, Maryland 20814, USA
    J Virol 76:11186-98. 2002
    ..However, no heterotypic activity was observed with envelope glycoproteins of the morbilliviruses Measles virus and Canine distemper virus...