Andrew G Sikora

Summary

Publications

  1. doi request reprint Bidirectional association of anogenital and oral cavity/pharyngeal carcinomas in men
    Andrew G Sikora
    Department of Otolaryngology, Mount Sinai School of Medicine, One Gustave L Levy Place, Box 1189, New York, NY 10029, USA
    Arch Otolaryngol Head Neck Surg 135:402-5. 2009
  2. pmc Anatomic sites at elevated risk of second primary cancer after an index head and neck cancer
    Luc G T Morris
    Head and Neck Service, Department of Surgery, Memorial Sloan Kettering Cancer Center, 1275 York Avenue, New York, NY 10021, USA
    Cancer Causes Control 22:671-9. 2011
  3. doi request reprint Racial disparities in incidence of human papillomavirus-associated oropharyngeal cancer in an urban population
    Ilana Ramer
    Department of Medical Education, Icahn School of Medicine at Mount Sinai, New York, NY, USA
    Cancer Epidemiol 44:91-95. 2016
  4. pmc Inducible nitric oxide synthase drives mTOR pathway activation and proliferation of human melanoma by reversible nitrosylation of TSC2
    Esther López-Rivera
    Authors Affiliations Departments of Otolaryngology, Dermatology, Immunology, and Oncological Sciences Division of Hematology and Oncology, Department of Medicine, Department of Otolaryngology, The Tisch Cancer Institute, Black Family Stem Cell Institute, Icahn School of Medicine at Mount Sinai The Tisch Cancer Institute Department of Genetics and Genomic Sciences, One Gustave L Levy Place, New York, New York and Departments of Melanoma Medical Oncology and Biostatistics, University of Texas MD Anderson Cancer Center, Houston, Texas
    Cancer Res 74:1067-78. 2014
  5. doi request reprint Synchronous cancers in patients with head and neck cancer: risks in the era of human papillomavirus-associated oropharyngeal cancer
    Kunal S Jain
    Head and Neck Service, Department of Surgery, Memorial Sloan Kettering Cancer Center, New York, NY, USA
    Cancer 119:1832-7. 2013
  6. doi request reprint Prognostic significance of p16 in locoregionally advanced head and neck cancer treated with concurrent 5-fluorouracil, hydroxyurea, cetuximab and intensity-modulated radiation therapy
    Charles C L Tong
    Department of Radiation Oncology, Mount Sinai School of Medicine, New York, NY 10029, USA
    Oncol Rep 27:1580-6. 2012
  7. pmc Second primary cancers after an index head and neck cancer: subsite-specific trends in the era of human papillomavirus-associated oropharyngeal cancer
    Luc G T Morris
    Head and Neck Service, Department of Surgery, Memorial Sloan Kettering Cancer Center, 1275 York Ave, New York, NY 10021, USA
    J Clin Oncol 29:739-46. 2011
  8. pmc Predictors of survival in mucosal melanoma of the head and neck
    Daniel Jethanamest
    Department of Otolaryngology Head and Neck Surgery, New York University School of Medicine, New York, NY, USA
    Ann Surg Oncol 18:2748-56. 2011
  9. doi request reprint iNOS expression in CD4+ T cells limits Treg induction by repressing TGFβ1: combined iNOS inhibition and Treg depletion unmask endogenous antitumor immunity
    Padmini Jayaraman
    Department of Otolaryngology Head and Neck Surgery, The Icahn School of Medicine at Mount Sinai, New York, New York Department of Oncological Sciences, The Icahn School of Medicine at Mount Sinai, New York, New York Department of Dermatology, The Icahn School of Medicine at Mount Sinai, New York, New York Immunology Institute, The Icahn School of Medicine at Mount Sinai, New York, New York Tisch Cancer Institute, The Icahn School of Medicine at Mount Sinai, New York, New York Head and Neck Cancer Research Program, The Icahn School of Medicine at Mount Sinai, New York, New York
    Clin Cancer Res 20:6439-51. 2014
  10. doi request reprint Recognizing and reversing the immunosuppressive tumor microenvironment of head and neck cancer
    Charles C L Tong
    Department of Otolaryngology, Head and Neck Surgery, The Mount Sinai School of Medicine, One Gustave L Levy Place, Box 1189, New York, NY, USA
    Immunol Res 54:266-74. 2012

Collaborators

Detail Information

Publications36

  1. doi request reprint Bidirectional association of anogenital and oral cavity/pharyngeal carcinomas in men
    Andrew G Sikora
    Department of Otolaryngology, Mount Sinai School of Medicine, One Gustave L Levy Place, Box 1189, New York, NY 10029, USA
    Arch Otolaryngol Head Neck Surg 135:402-5. 2009
    ..To test the hypothesis of a bidirectional association of anogenital and oral cavity/pharyngeal human papillomavirus (HPV)-associated cancers in men...
  2. pmc Anatomic sites at elevated risk of second primary cancer after an index head and neck cancer
    Luc G T Morris
    Head and Neck Service, Department of Surgery, Memorial Sloan Kettering Cancer Center, 1275 York Avenue, New York, NY 10021, USA
    Cancer Causes Control 22:671-9. 2011
    ..Our objectives were to quantify the excess risk of SPM across all anatomic sites in which SPM risk is meaningfully elevated, including non-HNLE sites, in a large cohort of US patients...
  3. doi request reprint Racial disparities in incidence of human papillomavirus-associated oropharyngeal cancer in an urban population
    Ilana Ramer
    Department of Medical Education, Icahn School of Medicine at Mount Sinai, New York, NY, USA
    Cancer Epidemiol 44:91-95. 2016
    ..We hypothesized that this disparity would be less marked in a racially and ethnically diverse population from New York City...
  4. pmc Inducible nitric oxide synthase drives mTOR pathway activation and proliferation of human melanoma by reversible nitrosylation of TSC2
    Esther López-Rivera
    Authors Affiliations Departments of Otolaryngology, Dermatology, Immunology, and Oncological Sciences Division of Hematology and Oncology, Department of Medicine, Department of Otolaryngology, The Tisch Cancer Institute, Black Family Stem Cell Institute, Icahn School of Medicine at Mount Sinai The Tisch Cancer Institute Department of Genetics and Genomic Sciences, One Gustave L Levy Place, New York, New York and Departments of Melanoma Medical Oncology and Biostatistics, University of Texas MD Anderson Cancer Center, Houston, Texas
    Cancer Res 74:1067-78. 2014
    ..This model is consistent with the known association of iNOS overexpression and poor prognosis in melanoma and other cancers...
  5. doi request reprint Synchronous cancers in patients with head and neck cancer: risks in the era of human papillomavirus-associated oropharyngeal cancer
    Kunal S Jain
    Head and Neck Service, Department of Surgery, Memorial Sloan Kettering Cancer Center, New York, NY, USA
    Cancer 119:1832-7. 2013
    ....
  6. doi request reprint Prognostic significance of p16 in locoregionally advanced head and neck cancer treated with concurrent 5-fluorouracil, hydroxyurea, cetuximab and intensity-modulated radiation therapy
    Charles C L Tong
    Department of Radiation Oncology, Mount Sinai School of Medicine, New York, NY 10029, USA
    Oncol Rep 27:1580-6. 2012
    ..The most common grade 3-4 toxicities were mucositis (46%), leukopenia (18%), anemia (18%) and dermatitis (17%). Concurrent 5-FU, HU, cetuximab and SIB-IMRT is a highly active regimen, particularly in patients with p16-positive disease...
  7. pmc Second primary cancers after an index head and neck cancer: subsite-specific trends in the era of human papillomavirus-associated oropharyngeal cancer
    Luc G T Morris
    Head and Neck Service, Department of Surgery, Memorial Sloan Kettering Cancer Center, 1275 York Ave, New York, NY 10021, USA
    J Clin Oncol 29:739-46. 2011
    ..Our objectives were to identify HNSCC subsite-specific differences in SPM risk and distribution and to describe trends in risk over 3 decades, before and during the era of human papillomavirus (HPV) -associated oropharyngeal SCC...
  8. pmc Predictors of survival in mucosal melanoma of the head and neck
    Daniel Jethanamest
    Department of Otolaryngology Head and Neck Surgery, New York University School of Medicine, New York, NY, USA
    Ann Surg Oncol 18:2748-56. 2011
    ..In order to identify factors predictive of survival, we analyzed MMHN outcomes in a large US cohort...
  9. doi request reprint iNOS expression in CD4+ T cells limits Treg induction by repressing TGFβ1: combined iNOS inhibition and Treg depletion unmask endogenous antitumor immunity
    Padmini Jayaraman
    Department of Otolaryngology Head and Neck Surgery, The Icahn School of Medicine at Mount Sinai, New York, New York Department of Oncological Sciences, The Icahn School of Medicine at Mount Sinai, New York, New York Department of Dermatology, The Icahn School of Medicine at Mount Sinai, New York, New York Immunology Institute, The Icahn School of Medicine at Mount Sinai, New York, New York Tisch Cancer Institute, The Icahn School of Medicine at Mount Sinai, New York, New York Head and Neck Cancer Research Program, The Icahn School of Medicine at Mount Sinai, New York, New York
    Clin Cancer Res 20:6439-51. 2014
    ..We used a syngeneic tumor model to functionally characterize the role of iNOS in regulation of CD4(+)FOXP3(+) regulatory T cells (Treg), and optimize the beneficial effects of iNOS inhibition on antitumor immunity...
  10. doi request reprint Recognizing and reversing the immunosuppressive tumor microenvironment of head and neck cancer
    Charles C L Tong
    Department of Otolaryngology, Head and Neck Surgery, The Mount Sinai School of Medicine, One Gustave L Levy Place, Box 1189, New York, NY, USA
    Immunol Res 54:266-74. 2012
    ..This article outlines significant immune-suppressive mechanisms in the HNSCC tumor microenvironment and potential approaches to enhancing the antitumor immune response...
  11. doi request reprint Impact of human papillomavirus and smoking on survival outcomes after transoral robotic surgery
    Chaz L Stucken
    Department of Otolaryngology Head and Neck Surgery, Icahn School of Medicine at Mount Sinai, New York, New York
    Head Neck 38:380-6. 2016
    ..The purpose of this study was to evaluate oncologic outcomes of head and neck squamous cell carcinoma (HNSCC) treated with transoral robotic surgery (TORS) based on human papillomavirus (HPV) and smoking risk factors...
  12. pmc Myeloid cell-derived inducible nitric oxide synthase suppresses M1 macrophage polarization
    Geming Lu
    Department of Medicine, Immunology Institute, Icahn School of Medicine at Mount Sinai, New York, New York 10029, USA
    Nat Commun 6:6676. 2015
    ..These results suggest that NO derived from iNOS in activated macrophages suppresses M1 macrophage polarization. ..
  13. pmc Molecular pathways: inflammation-associated nitric-oxide production as a cancer-supporting redox mechanism and a potential therapeutic target
    Elizabeth A Grimm
    Authors Affiliations Department of Melanoma Medical Oncology, The University of Texas MD Anderson Cancer Center, Houston, Texas and Departments of Otolaryngology, Immunology, Oncological Science, and Dermatology, Mount Sinai School of Medicine, New York, New York
    Clin Cancer Res 19:5557-63. 2013
    ..We contend that selected antioxidants be considered as part of the cancer treatment approach, as they are likely to provide a novel and mechanistically justified addition for therapeutic benefit...
  14. pmc The increasing incidence of thyroid cancer: the influence of access to care
    Luc G T Morris
    Head and Neck Service, Department of Surgery, Memorial Sloan Kettering Cancer Center, New York, NY 10065, USA
    Thyroid 23:885-91. 2013
    ..To conclude that overdiagnosis is occurring, evidence for an association between access to health care and the incidence of cancer is necessary...
  15. pmc Discrimination of benign and neoplastic mucosa with a high-resolution microendoscope (HRME) in head and neck cancer
    Peter M Vila
    Department of Otolaryngology Head and Neck Surgery, Mount Sinai School of Medicine, New York, NY, USA
    Ann Surg Oncol 19:3534-9. 2012
    ..Our goal was to determine the accuracy and inter-rater reliability of head and neck cancer specialists using high-resolution microendoscopic (HRME) images to discriminate between cancerous and benign mucosa...
  16. pmc Tumor-expressed inducible nitric oxide synthase controls induction of functional myeloid-derived suppressor cells through modulation of vascular endothelial growth factor release
    Padmini Jayaraman
    Department of Otolaryngology, Mount Sinai School of Medicine, New York, NY 10028, USA
    J Immunol 188:5365-76. 2012
    ..These data suggest a critical role for tumor-expressed iNOS in the recruitment and induction of functional MDSC by modulation of tumor VEGF secretion and upregulation of STAT3 and ROS in MDSC...
  17. pmc Feasibility of transoral robotic-assisted high-resolution microendoscopic imaging of oropharyngeal squamous cell carcinoma
    Alexis Patsias
    Department of Otolaryngology Head and Neck Surgery, Head and Neck Cancer Translational Research Program, The Icahn School of Medicine at Mount Sinai, New York, New York
    Head Neck 37:E99-102. 2015
    ..We aimed to integrate a miniaturized high-resolution fiber-optic microendoscope (HRME), which provides real-time histological assessment, with the da Vinci robotic system (Intuitive Surgical, Sunnyvale, CA)...
  18. pmc Reduced impact of nodal metastases as a prognostic factor for tonsil cancer in the HPV era
    Peter M Vila
    Department of Otolaryngology Head and Neck Surgery, Mount Sinai School of Medicine, New York, NY, USA
    Eur Arch Otorhinolaryngol 271:2523-9. 2014
    ....
  19. doi request reprint Conference scene: immune effector mechanisms in tumor immunity
    Andrew G Sikora
    Departments of Otolaryngology, Immunology, Oncological Sciences and Dermatology, Mount Sinai School of Medicine, New York, NY 10029, USA
    Immunotherapy 4:141-3. 2012
    ..The conference built on these early successes and aimed to push further into the uncharted territories of successful cancer immunotherapy...
  20. doi request reprint The basis of racial differences in the incidence of thyroid cancer
    Luc G T Morris
    Head and Neck Service, Department of Otolaryngology, New York University Cancer Institute, New York University School of Medicine, New York, NY, USA
    Ann Surg Oncol 15:1169-76. 2008
    ..The incidence of thyroid cancer in black Americans is half that in white Americans. It is unknown whether this gap represents a population difference in disease or is attributable to inferior cancer screening in the black population...
  21. pmc Tall-cell variant of papillary thyroid carcinoma: a matched-pair analysis of survival
    Luc G T Morris
    Head and Neck Service, Department of Surgery, Memorial Sloan Kettering Cancer Center, New York, New York 10021, USA
    Thyroid 20:153-8. 2010
    ..Our objective was to utilize a large cancer registry to obtain sufficient power to differentiate between outcomes in cases of TCV and PTC...
  22. ncbi request reprint Esthesioneuroblastoma: a population-based analysis of survival and prognostic factors
    Daniel Jethanamest
    Department of Otolaryngology, New York University School of Medicine, New York, NY, USA
    Arch Otolaryngol Head Neck Surg 133:276-80. 2007
    ..To investigate the characteristics associated with survival in esthesioneuroblastoma and to determine whether the modified Kadish staging system can predict outcome...
  23. ncbi request reprint Tamoxifen therapy for aggressive fibromatosis of the posterior triangle of the neck
    Luc G Morris
    Division of Head and Neck Surgery and Oncology, Department of Otolaryngology, New York University School of Medicine, New York, NY 1016, USA
    Otolaryngol Head Neck Surg 136:674-6. 2007
  24. pmc Targeting immune suppressing myeloid-derived suppressor cells in oncology
    Johnny Kao
    Department of Radiation Oncology, Mount Sinai School of Medicine, New York, NY 10029, United States
    Crit Rev Oncol Hematol 77:12-9. 2011
    ..Since c-kit can be readily inhibited by several small molecule inhibitors including imatinib, sunitinib and dasatinib, targeting immune suppressing cells can be readily accomplished in the clinic...
  25. pmc Chemoradiotherapy-induced upregulation of PD-1 antagonizes immunity to HPV-related oropharyngeal cancer
    Falguni Parikh
    Department of Otolaryngology, Icahn School of Medicine at Mount Sinai, New York, New York
    Cancer Res 74:7205-16. 2014
    ..These data strongly support testing of PD-1-blocking agents in combination with standard-of-care chemoradiotherapy for HPVOPC...
  26. pmc Optical imaging with a high-resolution microendoscope to identify cholesteatoma of the middle ear
    Lauren L Levy
    Department of Otolaryngology Head and Neck Surgery, Mount Sinai School of Medicine, New York, New York 10029, USA
    Laryngoscope 123:1016-20. 2013
    ....
  27. doi request reprint Transoral robotic resection and reconstruction for head and neck cancer
    Eric M Genden
    Mount Sinai School of Medicine, Department of Otolaryngology Head and Neck Surgery, New York, New York 10029, USA
    Laryngoscope 121:1668-74. 2011
    ..To evaluate the patterns of failure, survival, and functional outcomes for patients treated with transoral robotic surgery (TORS) and compare these results with those from a cohort of patients treated with concurrent chemoradiation (CRT)...
  28. doi request reprint HPV-induced oropharyngeal cancer, immune response and response to therapy
    Ha Linh Vu
    Department of Radiation Oncology, Mount Sinai School of Medicine, New York, NY, United States
    Cancer Lett 288:149-55. 2010
    ..This article outlines several mechanisms whereby the observed improved response of HPV-positive tumors to radiotherapy may be related to enhancement of the immune response following radiotherapy...
  29. doi request reprint Prevalence of severe obstructive sleep apnea in pediatric adenotonsillectomy patients
    Nancy Jiang
    Department of Otolaryngology Head and Neck Surgery, Icahn School of Medicine at Mount Sinai, New York, New York, U S A
    Laryngoscope 124:1975-8. 2014
    ..To determine the prevalence of severe obstructive sleep apnea (OSA) in a pediatric population who underwent indicated surgery for sleep disordered breathing (SDB)...
  30. pmc Requirement for innate immunity and CD90⁺ NK1.1⁻ lymphocytes to treat established melanoma with chemo-immunotherapy
    Marina Moskalenko
    Division of Hematology and Oncology, Tisch Cancer Institute, Icahn School of Medicine at Mount Sinai, New York, New York
    Cancer Immunol Res 3:296-304. 2015
    ..Tumor clearance during combination chemo-immunotherapy with monoclonal antibodies against native antigen is mediated by the innate immune system. We highlight a novel potential role for CD90⁺NK1.1⁻ ILCs in chemo-immunotherapy...
  31. ncbi request reprint Thyroglossal duct cyst carcinoma: case report and review of the literature
    David W Jang
    Department of Otolaryngology Head and Neck Surgery, Mount Sinai School of Medicine, One Gustave Levy Place, Box 1189, New York, NY 10029, USA
    Ear Nose Throat J 92:E12-4. 2013
    ..Histologic analysis after a Sistrunk procedure revealed a small focus of papillary carcinoma within the TGDC. The patient subsequently underwent total thyroidectomy with no evidence of carcinoma on histologic examination. ..
  32. doi request reprint Transoral robotic surgery for the management of oropharyngeal minor salivary gland tumors
    Nathaniel L Villanueva
    Department of Otolaryngology Head and Neck Surgery, Mount Sinai School of Medicine, New York, New York
    Head Neck 36:28-33. 2014
    ..In this study we report our preliminary experience with the use of transoral robotic surgery (TORS) for the management of minor salivary gland malignancies of the oropharynx and outcomes...
  33. pmc T cell–derived inducible nitric oxide synthase switches off Th17 cell differentiation
    - Jianjun Yang
    Department of Medicine, Immunology Institute, Mount Sinai School of Medicine, New York, NY 10029, USA
    J Exp Med 210:1447-62. 2013
    ..These results suggest that NO derived from iNOS in activated T cells plays a negative role in the regulation of T(H)17 cell differentiation and highlight the importance of intrinsic programs for the control of T(H)17 immune responses...
  34. ncbi request reprint Emergency parotidectomy for penetrating zone III neck trauma
    Luc G Morris
    Division of Acute Care Surgery, New York Presbyterian Hospital, Columbia College of Physicians and Surgeons, 161 Fort Washington Ave, Herbert Irving Pavilion, HIP 8 808, New York, NY 10032, USA
    Arch Surg 142:1206-8. 2007
    ..The management of penetrating trauma to the parotid region,and relevant anatomy, are discussed...
  35. ncbi request reprint Oropharyngeal kaposi sarcoma in related persons negative for human immunodeficiency virus
    Andrew G Sikora
    Department of Otolaryngology Head and Neck Surgery, New York University School of Medicine, New York, New York, USA
    Ann Otol Rhinol Laryngol 117:172-6. 2008
    ..We describe an unusual presentation of KS in 2 related individuals and describe our attempts to determine whether oropharyngeal KS is associated with human herpesvirus 8 (HHV-8)...
  36. ncbi request reprint The changing demographics of head and neck squamous cell carcinoma in the United States
    Andrew G Sikora
    Department of Otolaryngology, New York University School of Medicine, New York, New York, USA
    Laryngoscope 114:1915-23. 2004
    ..During this time, substantial immigration from other countries has occurred, and the average lifespan has increased. We tested the hypothesis that these trends have altered the HNSCCA patient population...