Kevin N Sheth

Summary

Publications

  1. doi request reprint Packed red blood cell transfusion and decreased mortality in intracerebral hemorrhage
    Kevin N Sheth
    Department of Neurology, Division of Stroke and Neurocritical Care, University of Maryland Medical Center, Baltimore, Maryland 21201, USA
    Neurosurgery 68:1286-92. 2011
  2. ncbi request reprint Neurocritical care and periprocedural blood pressure management in acute stroke
    Kevin N Sheth
    Department of Neurology, University of Maryland School of Medicine, Program in Shock, Trauma, and Anesthesiology Research STAR, R Adams Cowley Shock Trauma Center, Baltimore, MD, USA
    Neurology 79:S199-204. 2012
  3. doi request reprint Education research: A program perspective on learning how to teach
    Kevin N Sheth
    Massachusetts General Hospital, Department of Neurology, 55 Fruit Street, Blake 12 Neuro ICU, Boston, MA 02114, USA
    Neurology 70:e75-7. 2008
  4. doi request reprint Intravenous rt-PA is not associated with increased risk of hemorrhage in patients with intracranial aneurysms
    Kevin N Sheth
    Department of Neurology, Shock Trauma and Anesthesiology Research Center, University of Maryland School of Medicine, Baltimore, MD, USA
    Neurocrit Care 17:199-203. 2012
  5. pmc Pilot study of intravenous glyburide in patients with a large ischemic stroke
    Kevin N Sheth
    From the Division of Neurocritical Care and Emergency Neurology, Department of Neurology, Yale University School of Medicine, New Haven, CT K N S Division of Neurocritical Care and Emergency Neurology, Department of Neurology W T K and Division of Neuroradiology, Department of Radiology A J Y, Massachusetts General Hospital, Boston Department of Public Health Services, Medical University of South Carolina, Charleston J J E Department of Neurology, Michael E DeBakey VA Medical, Baylor College of Medicine, Houston, TX T A K, P M Department of Neurology, Klinik und Poliklinik fur Neurologie, Kopf und Neurozentrum, Universitatsklinikum Hamburg Eppendorf, Hamburg, Germany G T Department of Neurology, Melbourne Brain Centre at the Royal Melbourne Hospital, University of Melbourne, Parkville, Australia B C, G A D, S M D Department of Neurology, Stanford University School of Medicine, CA G W A Remedy Pharmaceuticals, Inc, New York, NY S J and Departments of Neurosurgery J M S and Neurology B J S, University of Maryland School of Medicine, Baltimore
    Stroke 45:281-3. 2014
  6. pmc Fluid-attenuated inversion recovery hyperintensity correlates with matrix metalloproteinase-9 level and hemorrhagic transformation in acute ischemic stroke
    Ruchira Jha
    From the Department of Neurology, Massachusetts General Hospital, Boston, MA R J, T W K B, L P, W T K Department of Neurology and Psychiatry, Policlinico Umberto I Hospital, Sapienza University of Rome, Rome, Italy S L Department of Neurology, Warren Alpert Medical School of Brown University, Providence, RI K L F and Department of Neurology, Yale New Haven Hospital, New Haven, CT K N S
    Stroke 45:1040-5. 2014
  7. doi request reprint Measurement of perihematomal edema in intracerebral hemorrhage
    Sebastian Urday
    From the Division of Neurocritical Care and Emergency Neurology, Department of Neurology, Yale University School of Medicine, New Haven, CT S U, L A B, D W G, K N S Center for Human Genetic Research, Division of Neurocritical Care and Emergency Neurology, Department of Neurology, Massachusetts General Hospital, Harvard Medical School, Boston, MA A V, A M A, T W K B, W T K, J R and Stroke Division, Department of Neurology, Beth Israel Deaconess Medical Center, Boston, MA M H S
    Stroke 46:1116-9. 2015
  8. pmc Posttreatment variables improve outcome prediction after intra-arterial therapy for acute ischemic stroke
    Shyam Prabhakaran
    Department of Neurology, Northwestern University Feinberg School of Medicine, Chicago, Ill, USA
    Cerebrovasc Dis 37:356-63. 2014
  9. pmc Rate of Perihematomal Edema Expansion Predicts Outcome After Intracerebral Hemorrhage
    Sebastian Urday
    1Department of Neurology, Yale University School of Medicine, New Haven, CT 2Department of Neurology, Massachusetts General Hospital, Boston, MA 3Department of Neurology, Beth Israel Deaconess Medical Center, Boston, MA 4Department of Neurosurgery, University of Maryland School of Medicine, Baltimore, MD
    Crit Care Med 44:790-7. 2016
  10. doi request reprint Novel Imaging Markers of Ischemic Cerebral Edema and Its Association with Neurological Outcome
    W Taylor Kimberly
    Department of Neurology, Massachusetts General Hospital, Lunder 644, 55 Fruit Street, Boston, MA, 02114, USA
    Acta Neurochir Suppl 121:223-6. 2016

Collaborators

Detail Information

Publications30

  1. doi request reprint Packed red blood cell transfusion and decreased mortality in intracerebral hemorrhage
    Kevin N Sheth
    Department of Neurology, Division of Stroke and Neurocritical Care, University of Maryland Medical Center, Baltimore, Maryland 21201, USA
    Neurosurgery 68:1286-92. 2011
    ..Although packed red blood cell (PRBC) transfusion appears to increase brain tissue oxygen, it is unknown whether such transfusions, which are commonly administered in patients with intracranial hemorrhage, alter outcome...
  2. ncbi request reprint Neurocritical care and periprocedural blood pressure management in acute stroke
    Kevin N Sheth
    Department of Neurology, University of Maryland School of Medicine, Program in Shock, Trauma, and Anesthesiology Research STAR, R Adams Cowley Shock Trauma Center, Baltimore, MD, USA
    Neurology 79:S199-204. 2012
    ..Finally, the article reviews major ongoing clinical trials for BP management in this setting. Recommendations made in this article may serve as a benchmark for future research in BP management in this patient population...
  3. doi request reprint Education research: A program perspective on learning how to teach
    Kevin N Sheth
    Massachusetts General Hospital, Department of Neurology, 55 Fruit Street, Blake 12 Neuro ICU, Boston, MA 02114, USA
    Neurology 70:e75-7. 2008
  4. doi request reprint Intravenous rt-PA is not associated with increased risk of hemorrhage in patients with intracranial aneurysms
    Kevin N Sheth
    Department of Neurology, Shock Trauma and Anesthesiology Research Center, University of Maryland School of Medicine, Baltimore, MD, USA
    Neurocrit Care 17:199-203. 2012
    ..This study was designed to test the hypothesis that the administration of rt-PA is safe in patients who have an unruptured intracranial aneurysm...
  5. pmc Pilot study of intravenous glyburide in patients with a large ischemic stroke
    Kevin N Sheth
    From the Division of Neurocritical Care and Emergency Neurology, Department of Neurology, Yale University School of Medicine, New Haven, CT K N S Division of Neurocritical Care and Emergency Neurology, Department of Neurology W T K and Division of Neuroradiology, Department of Radiology A J Y, Massachusetts General Hospital, Boston Department of Public Health Services, Medical University of South Carolina, Charleston J J E Department of Neurology, Michael E DeBakey VA Medical, Baylor College of Medicine, Houston, TX T A K, P M Department of Neurology, Klinik und Poliklinik fur Neurologie, Kopf und Neurozentrum, Universitatsklinikum Hamburg Eppendorf, Hamburg, Germany G T Department of Neurology, Melbourne Brain Centre at the Royal Melbourne Hospital, University of Melbourne, Parkville, Australia B C, G A D, S M D Department of Neurology, Stanford University School of Medicine, CA G W A Remedy Pharmaceuticals, Inc, New York, NY S J and Departments of Neurosurgery J M S and Neurology B J S, University of Maryland School of Medicine, Baltimore
    Stroke 45:281-3. 2014
    ..We assessed the feasibility of recruiting and treating patients with severe stroke while obtaining preliminary information on the safety and tolerability of RP-1127 (glyburide for injection)...
  6. pmc Fluid-attenuated inversion recovery hyperintensity correlates with matrix metalloproteinase-9 level and hemorrhagic transformation in acute ischemic stroke
    Ruchira Jha
    From the Department of Neurology, Massachusetts General Hospital, Boston, MA R J, T W K B, L P, W T K Department of Neurology and Psychiatry, Policlinico Umberto I Hospital, Sapienza University of Rome, Rome, Italy S L Department of Neurology, Warren Alpert Medical School of Brown University, Providence, RI K L F and Department of Neurology, Yale New Haven Hospital, New Haven, CT K N S
    Stroke 45:1040-5. 2014
    ..It is controversial whether early fluid-attenuated inversion recovery (FLAIR) hyperintensity on brain MRI predicts hemorrhagic transformation (HT). We assessed whether FLAIR hyperintensity was associated with MMP-9 and HT...
  7. doi request reprint Measurement of perihematomal edema in intracerebral hemorrhage
    Sebastian Urday
    From the Division of Neurocritical Care and Emergency Neurology, Department of Neurology, Yale University School of Medicine, New Haven, CT S U, L A B, D W G, K N S Center for Human Genetic Research, Division of Neurocritical Care and Emergency Neurology, Department of Neurology, Massachusetts General Hospital, Harvard Medical School, Boston, MA A V, A M A, T W K B, W T K, J R and Stroke Division, Department of Neurology, Beth Israel Deaconess Medical Center, Boston, MA M H S
    Stroke 46:1116-9. 2015
    ..PHE measurement on computed tomography (CT) is challenging, and the principles used to detect PHE have not been described fully. We developed a systematic approach for CT-based measurement of PHE...
  8. pmc Posttreatment variables improve outcome prediction after intra-arterial therapy for acute ischemic stroke
    Shyam Prabhakaran
    Department of Neurology, Northwestern University Feinberg School of Medicine, Chicago, Ill, USA
    Cerebrovasc Dis 37:356-63. 2014
    ..We sought to derive and validate an outcome prediction score for AIS patients undergoing ERT based on readily available pretreatment and posttreatment factors...
  9. pmc Rate of Perihematomal Edema Expansion Predicts Outcome After Intracerebral Hemorrhage
    Sebastian Urday
    1Department of Neurology, Yale University School of Medicine, New Haven, CT 2Department of Neurology, Massachusetts General Hospital, Boston, MA 3Department of Neurology, Beth Israel Deaconess Medical Center, Boston, MA 4Department of Neurosurgery, University of Maryland School of Medicine, Baltimore, MD
    Crit Care Med 44:790-7. 2016
    ..Whether perihematomal edema is an independent predictor of neurologic outcome is controversial. We sought to determine whether perihematomal edema expansion rate predicts outcome after intracerebral hemorrhage...
  10. doi request reprint Novel Imaging Markers of Ischemic Cerebral Edema and Its Association with Neurological Outcome
    W Taylor Kimberly
    Department of Neurology, Massachusetts General Hospital, Lunder 644, 55 Fruit Street, Boston, MA, 02114, USA
    Acta Neurochir Suppl 121:223-6. 2016
    ..We previously reported that ICE independently predicted neurological outcome after adjustment for known risk factors. We found that an ICE volume of 11 mL or greater was associated with worse neurological outcome. ..
  11. pmc Validating imaging biomarkers of cerebral edema in patients with severe ischemic stroke
    Albert J Yoo
    Department of Radiology, Massachusetts General Hospital, Boston, Massachusetts, USA
    J Stroke Cerebrovasc Dis 22:742-9. 2013
    ..We sought to test whether magnetic resonance imaging (MRI)-based metrics would reliably change during the early subacute period in a manner consistent with edema and whether they would correlate with relevant clinical endpoints...
  12. doi request reprint No increased risk of symptomatic intracerebral hemorrhage after thrombolysis in patients with European Cooperative Acute Stroke Study (ECASS) exclusion criteria
    Carolyn A Cronin
    Department of Neurology, University of Maryland School of Medicine, 110 South Paca Street, 3rd Floor, Baltimore, MD 21201, USA
    Stroke 43:1684-6. 2012
    ..We tested the hypothesis that thrombolysis is not safe in patients with 1 of the additional exclusion criteria...
  13. doi request reprint Higher volume endovascular stroke centers have faster times to treatment, higher reperfusion rates and higher rates of good clinical outcomes
    Rishi Gupta
    Department of Neurology, Emory University School of Medicine, Marcus Stroke and Neuroscience Center, Grady Memorial Hospital, Atlanta, GA, USA
    J Neurointerv Surg 5:294-7. 2013
    ..Unfortunately, the sequence of events prior to reperfusion may lead to significant treatment delays. This study sought to determine if high-volume (HV) centers were efficient at delivery of endovascular treatment approaches...
  14. pmc Glibenclamide in cerebral ischemia and stroke
    J Marc Simard
    Department of Neurosurgery, University of Maryland School of Medicine, 22 S Greene St, Suite S12D, Baltimore, MD, 21201 1595, USA
    Neurocrit Care 20:319-33. 2014
    ..The findings reviewed here provide a strong foundation for a translational research program to study glibenclamide in patients with ischemic stroke...
  15. doi request reprint Glyburide is associated with attenuated vasogenic edema in stroke patients
    W Taylor Kimberly
    Center for Human Genetic Research and Division of Neurocritical Care and Emergency Neurology, Massachusetts General Hospital, Harvard Medical School, Boston, MA, USA
    Neurocrit Care 20:193-201. 2014
    ..However, the relevance of this pathway to the development of cerebral edema in stroke patients is not known...
  16. pmc Confounding by indication in retrospective studies of intracerebral hemorrhage: antiepileptic treatment and mortality
    Thomas W K Battey
    Hemorrhagic Stroke Research Group, Massachusetts General Hospital, Boston, MA, USA
    Neurocrit Care 17:361-6. 2012
    ..Published studies on AED treatment in ICH have provided conflicting results. We investigated the effect of AED treatment on 90-day mortality after ICH in a large prospectively ascertained cohort...
  17. doi request reprint Glyburide Advantage in Malignant Edema and Stroke (GAMES-RP) Trial: Rationale and Design
    Kevin N Sheth
    Division of Neurocritical Care and Emergency Neurology, Department of Neurology, Yale University School of Medicine, 15 York Street, LCI 1003, New Haven, CT, 06510, USA
    Neurocrit Care 24:132-9. 2016
    ..We hypothesize that treatment with RP-1127 (Glyburide for Injection) reduces formation of brain edema in patients after large anterior circulation infarction...
  18. pmc Clinician judgment vs formal scales for predicting intracerebral hemorrhage outcomes
    David Y Hwang
    From the Division of Neurocritical Care and Emergency Neurology D Y H, K N S, Department of Neurology, Yale School of Medicine, New Haven, CT the Maryland Stroke Center C A D, M J S, T D W, Baltimore the Center for Public Health Genomics and Department of Biostatistical Sciences C D L, M E C, Division of Public Health Sciences, Wake Forest School of Medicine, Winston Salem, NC the Center for Human Genetic Research J R, T W K B, Boston, MA the University of Miami S K, M L P, Miller School of Medicine, FL Duke University Medical Center M L J, J M, Durham, NC the Department of Neurology J L O, D W, University of Cincinnati College of Medicine, OH and the Baltimore Veterans Administration Medical Center and University of Maryland School of Medicine S J K
    Neurology 86:126-33. 2016
    ..To compare the performance of formal prognostic instruments vs subjective clinical judgment with regards to predicting functional outcome in patients with spontaneous intracerebral hemorrhage (ICH)...
  19. doi request reprint Targeting secondary injury in intracerebral haemorrhage--perihaematomal oedema
    Sebastian Urday
    Department of Neurology, Yale University School of Medicine, 333 Cedar Street, New Haven, CT 06510, USA
    Nat Rev Neurol 11:111-22. 2015
    ..Our discussion emphasizes that PHO has clinical relevance both as a therapeutic target, owing to its augmentation of the mass effect of a haemorrhage, and as a surrogate marker for novel interventions that target secondary injury. ..
  20. doi request reprint Adherence to Third European Cooperative Acute Stroke Study 3- to 4.5-hour exclusions and association with outcome: data from Get with the Guidelines-Stroke
    Carolyn A Cronin
    From the Department of Neurology, University of Maryland School of Medicine, Baltimore C A C Department of Neurology, Yale School of Medicine, New Haven, CT K N S Duke Clinical Research Institute, Durham, NC X Z, A F H Department of Neurology, Hospital of the University of Pennsylvania, Philadelphia S R M Department of Neurology, University of Texas Southwestern, Dallas D M O Department of Cardiology, Brigham and Women s Hospital and Harvard Medical School, Boston, MA D L B Department of Neurology, Institute for Heart, Vascular and Stroke Care, Massachusetts General Hospital, Boston and Harvard Medical School, MA L H S and Department of Clinical Neurosciences and Hotchkiss Brain Institute, University of Calgary, Calgary, Canada E E S
    Stroke 45:2745-9. 2014
    ..We investigated adherence to these additional exclusion criteria for patients treated 3 to 4.5 hours from onset and their association with outcome...
  21. pmc Outcomes in severe middle cerebral artery ischemic stroke
    Brian P Walcott
    Harvard Medical School, Boston, MA, USA
    Neurocrit Care 21:20-6. 2014
    ..We assessed the hypothesis that patient-specific variables may be associated with outcomes. We also sought to describe under-recognized patient-centered outcomes...
  22. pmc Does inhibiting Sur1 complement rt-PA in cerebral ischemia?
    J Marc Simard
    Department of Neurosurgery, University of Maryland School of Medicine, Baltimore, Maryland, USA
    Ann N Y Acad Sci 1268:95-107. 2012
    ..Inhibition of Sur1 with injectable glyburide holds promise for ameliorating rt-PA-associated HT in stroke...
  23. pmc Advanced modality imaging evaluation in acute ischemic stroke may lead to delayed endovascular reperfusion therapy without improvement in clinical outcomes
    Kevin N Sheth
    Department of Neurology, University of Maryland School of Medicine, Baltimore, Maryland, USA
    J Neurointerv Surg 5:i62-5. 2013
    ..We studied the effect of advanced modality imaging with CT perfusion (CTP) or MRI compared with non-contrast CT (NCT) in a multicenter cohort...
  24. ncbi request reprint Prognosis in intracerebral hemorrhage
    Kenneth M Crandall
    Department of Neurosurgery, University of Maryland School of Medicine, Baltimore, MD, USA
    Rev Neurol Dis 8:23-9. 2011
    ..The use and interpretation of these ever-advancing scales may allow physicians to better predict outcome and assist families in making important care-related decisions...
  25. pmc Prophylactic Antiepileptic Drug Use and Outcome in the Ethnic/Racial Variations of Intracerebral Hemorrhage Study
    Kevin N Sheth
    From the Department of Neurology, Yale University School of Medicine, New Haven, CT K N S Department of Neurology, Baylor College of Medicine, Houston, TX S R M Department of Neurology and Rehabilitation Medicine, University of Cincinnati, OH C J M, J O, D W Department of Neurology, University of Miami School of Medicine, Miami, FL S K Department of Neurology, College of Physicians and Surgeons, Columbia University, New York M S V E Department of Neurology, University of Southern California, Los Angeles G S Department of Neurology, University of Maryland School of Medicine, Baltimore, MD S J K Department of Neurology, Emory University School of Medicine, Atlanta, GA M F Department of Neurology, Massachusetts General Hospital, Boston, MA J R Department of Biostatistical Sciences and Center for Public Health Genomics, Wake Forest School of Medicine, Winston Salem, NC C D L, M E C and Office of Clinical Research, National Institute of Neurological Disorders and Stroke, Bethesda, MD S P W
    Stroke 46:3532-5. 2015
    ..This analysis describes prevalence of prophylactic AED use, as directed by treating clinicians, in a prospective ICH cohort and tests the hypothesis that it is associated with poor outcome...
  26. doi request reprint Prediction of poor outcome in cerebellar infarction by diffusion MRI
    Zahari Tchopev
    University of Maryland College Park, College Park, MD, USA
    Neurocrit Care 19:276-82. 2013
    ..We tested the hypothesis that MRI-based volumetric assessment of cerebellar infarcts can provide reliable information for the prediction of poor outcome...
  27. doi request reprint Hypertonic saline and mannitol therapy in critical care neurology
    Holly E Hinson
    Neurosciences Critical Care, Johns Hopkins Medical Institutions, Baltimore, MD, USA
    J Intensive Care Med 28:3-11. 2013
    ..This review will summarize the evidence for the use of mannitol and hypertonic saline in a variety of disease states causing cerebral edema, as well as outlining monitoring and safety considerations...
  28. doi request reprint Intracranial pressure dose and outcome in traumatic brain injury
    Kevin N Sheth
    Department of Neurology, University of Maryland School of Medicine, Baltimore, MD 21201, USA
    Neurocrit Care 18:26-32. 2013
    ..The aim of this study was to determine the association between area under the curve measurement of elevated ICP and clinical outcome...
  29. pmc Comparison of hematoma shape and volume estimates in warfarin versus non-warfarin-related intracerebral hemorrhage
    Kevin N Sheth
    Division of Neurology, University of Maryland Medical Center, Baltimore, MD, USA
    Neurocrit Care 12:30-4. 2010
    ..We examined hematoma shape and methods of volume assessment in patients with OAT-ICH...
  30. ncbi request reprint The privilege of practicing medicine
    Kevin N Sheth
    University of Pennsylvania, Philadelphia, USA
    Acad Med 78:96. 2003