Iurii Semenov

Summary

Publications

  1. pmc Recruitment of the intracellular Ca2+ by ultrashort electric stimuli: the impact of pulse duration
    Iurii Semenov
    Frank Reidy Research Center for Bioelectrics, Old Dominion University, Norfolk, VA 23508, USA
    Cell Calcium 54:145-50. 2013
  2. pmc Primary pathways of intracellular Ca(2+) mobilization by nanosecond pulsed electric field
    Iurii Semenov
    Frank Reidy Research Center for Bioelectrics, Old Dominion University, Norfolk, VA, USA
    Biochim Biophys Acta 1828:981-9. 2013
  3. pmc Ion transport into cells exposed to monopolar and bipolar nanosecond pulses
    Karl H Schoenbach
    Frank Reidy Research Center for Bioelectrics, Old Dominion University, Norfolk, VA 23508, USA Electronic address
    Bioelectrochemistry 103:44-51. 2015
  4. pmc Cancellation of cellular responses to nanoelectroporation by reversing the stimulus polarity
    Andrei G Pakhomov
    Frank Reidy Research Center for Bioelectrics, Old Dominion University, 4211 Monarch Way, Suite 300, Norfolk, VA, 23508, USA
    Cell Mol Life Sci 71:4431-41. 2014
  5. pmc Picosecond and Terahertz Perturbation of Interfacial Water and Electropermeabilization of Biological Membranes
    P Thomas Vernier
    Frank Reidy Research Center for Bioelectrics, Old Dominion University, 4211 Monarch Way, Norfolk, VA, 23508, USA
    J Membr Biol 248:837-47. 2015
  6. pmc Cell stimulation and calcium mobilization by picosecond electric pulses
    Iurii Semenov
    Frank Reidy Research Center for Bioelectrics, Old Dominion University, Norfolk, VA, USA
    Bioelectrochemistry 105:65-71. 2015
  7. pmc Diffuse, non-polar electropermeabilization and reduced propidium uptake distinguish the effect of nanosecond electric pulses
    Iurii Semenov
    Frank Reidy Research Center for Bioelectrics, Old Dominion University, Norfolk, VA 23508, USA
    Biochim Biophys Acta 1848:2118-25. 2015
  8. pmc Ablation of Myocardial Tissue With Nanosecond Pulsed Electric Fields
    Fei Xie
    Department of Electrical and Computer Engineering, Old Dominion University, Norfolk, Virginia, United States of America
    PLoS ONE 10:e0144833. 2015
  9. pmc Disassembly of actin structures by nanosecond pulsed electric field is a downstream effect of cell swelling
    Andrei G Pakhomov
    Frank Reidy Research Center for Bioelectrics, Old Dominion University, Norfolk, VA, USA Electronic address
    Bioelectrochemistry 100:88-95. 2014
  10. pmc Multiple nanosecond electric pulses increase the number but not the size of long-lived nanopores in the cell membrane
    Andrei G Pakhomov
    Frank Reidy Research Center for Bioelectrics, Old Dominion University, Norfolk, VA, USA Electronic address
    Biochim Biophys Acta 1848:958-66. 2015

Collaborators

Detail Information

Publications12

  1. pmc Recruitment of the intracellular Ca2+ by ultrashort electric stimuli: the impact of pulse duration
    Iurii Semenov
    Frank Reidy Research Center for Bioelectrics, Old Dominion University, Norfolk, VA 23508, USA
    Cell Calcium 54:145-50. 2013
    ..We conclude that nanosecond stimuli mimic Ca2+ signaling while bypassing the usual receptor- and channels-mediated cascades. The recruitment of the intracellular Ca2+ can be controlled by the duration of the stimulus...
  2. pmc Primary pathways of intracellular Ca(2+) mobilization by nanosecond pulsed electric field
    Iurii Semenov
    Frank Reidy Research Center for Bioelectrics, Old Dominion University, Norfolk, VA, USA
    Biochim Biophys Acta 1828:981-9. 2013
    ..NsPEF stimulation may serve as a unique method to mobilize [Ca(2+)](i) and activate downstream cascades while bypassing the plasma membrane receptors...
  3. pmc Ion transport into cells exposed to monopolar and bipolar nanosecond pulses
    Karl H Schoenbach
    Frank Reidy Research Center for Bioelectrics, Old Dominion University, Norfolk, VA 23508, USA Electronic address
    Bioelectrochemistry 103:44-51. 2015
    ..The measured calcium ion uptake obtained with bipolar pulses also allowed us to determine the membrane pore recovery time. The calculated recovery time constants are on the order of 10 μs...
  4. pmc Cancellation of cellular responses to nanoelectroporation by reversing the stimulus polarity
    Andrei G Pakhomov
    Frank Reidy Research Center for Bioelectrics, Old Dominion University, 4211 Monarch Way, Suite 300, Norfolk, VA, 23508, USA
    Cell Mol Life Sci 71:4431-41. 2014
    ..Cancellation impacts nsEP applications in cancer therapy, electrostimulation, and biotechnology, and provides new insights into effects of more complex waveforms, including pulsed electromagnetic emissions. ..
  5. pmc Picosecond and Terahertz Perturbation of Interfacial Water and Electropermeabilization of Biological Membranes
    P Thomas Vernier
    Frank Reidy Research Center for Bioelectrics, Old Dominion University, 4211 Monarch Way, Norfolk, VA, 23508, USA
    J Membr Biol 248:837-47. 2015
    ....
  6. pmc Cell stimulation and calcium mobilization by picosecond electric pulses
    Iurii Semenov
    Frank Reidy Research Center for Bioelectrics, Old Dominion University, Norfolk, VA, USA
    Bioelectrochemistry 105:65-71. 2015
    ..06 K per psEP), or membrane depolarization by opening of VG Na(+) channels...
  7. pmc Diffuse, non-polar electropermeabilization and reduced propidium uptake distinguish the effect of nanosecond electric pulses
    Iurii Semenov
    Frank Reidy Research Center for Bioelectrics, Old Dominion University, Norfolk, VA 23508, USA
    Biochim Biophys Acta 1848:2118-25. 2015
    ..In a stark contrast, nsEP evoked a "supra-electroporation" pattern of slower but spatially uniform Ca2+ entry. Thus nsEP and msEP had comparable dose efficiency, but differed profoundly in the size and localization of electropores...
  8. pmc Ablation of Myocardial Tissue With Nanosecond Pulsed Electric Fields
    Fei Xie
    Department of Electrical and Computer Engineering, Old Dominion University, Norfolk, Virginia, United States of America
    PLoS ONE 10:e0144833. 2015
    ..We demonstrate that ablation with nanosecond pulsed electric fields (nsPEFs) can potentially overcome these limitations...
  9. pmc Disassembly of actin structures by nanosecond pulsed electric field is a downstream effect of cell swelling
    Andrei G Pakhomov
    Frank Reidy Research Center for Bioelectrics, Old Dominion University, Norfolk, VA, USA Electronic address
    Bioelectrochemistry 100:88-95. 2014
    ..We conclude that disintegration of the actin cytoskeleton was a result of cell swelling, which, in turn, was caused by cell permeabilization by nsPEF and transmembrane diffusion of solutes which led to the osmotic imbalance...
  10. pmc Multiple nanosecond electric pulses increase the number but not the size of long-lived nanopores in the cell membrane
    Andrei G Pakhomov
    Frank Reidy Research Center for Bioelectrics, Old Dominion University, Norfolk, VA, USA Electronic address
    Biochim Biophys Acta 1848:958-66. 2015
    ..The constant YP/Pr influx ratio for trains of 5 to 100 pulses suggests that increasing the number of pulses permeabilizes cells to a greater extent by increasing the pore number and not the pore diameter. ..
  11. pmc Calcium-mediated pore expansion and cell death following nanoelectroporation
    Olga N Pakhomova
    Frank Reidy Research Center for Bioelectrics, Old Dominion University, Norfolk, VA, USA Electronic address
    Biochim Biophys Acta 1838:2547-54. 2014
    ..We conclude that the high-Ca(2+)-dependent necrotic death in nsPEF-treated cells is effected by a delayed, sudden, and osmotically-independent pore expansion (or de novo formation of larger pores), but not by the membrane rupture. ..
  12. pmc Two modes of cell death caused by exposure to nanosecond pulsed electric field
    Olga N Pakhomova
    Frank Reidy Research Center for Bioelectrics, Old Dominion University, Norfolk, Virginia, USA
    PLoS ONE 8:e70278. 2013
    ..The balance between the two modes of cell death can be controlled by enabling or blocking cell swelling. ..