Giovanni Scapagnini

Summary

Publications

  1. pmc Enhancement of mitochondrial biogenesis with polyphenols: combined effects of resveratrol and equol in human endothelial cells
    Sergio Davinelli
    Department of Medicine and Health Sciences, University of Molise, Campobasso 86100, Italy
    Immun Ageing 10:28. 2013
  2. doi request reprint Epigenetic nutraceutical diets in Alzheimer's disease
    S Davinelli
    Giovanni Scapagnini, Department of Medicine and Health Sciences, University of Molise, Campobasso 86100, Italy
    J Nutr Health Aging 18:800-5. 2014
  3. pmc Cocoa bioactive compounds: significance and potential for the maintenance of skin health
    Giovanni Scapagnini
    Department of Medicine and Health Sciences, University of Molise, Campobasso 86100, Italy
    Nutrients 6:3202-13. 2014
  4. pmc Sulfur compounds block MCP-1 production by Mycoplasma fermentans-infected macrophages through NF-κB inhibition
    Francesca Benedetti
    Institute of Human Virology, University of Maryland School of Medicine, Baltimore, MD 21201, USA
    J Transl Med 12:145. 2014
  5. pmc "Positive biology": the centenarian lesson
    Calogero Caruso
    Department of Pathobiology and Medical and Forensic Biotechnologies, University of Palermo, Corso Tukory 211, 90134, Palermo, Italy
    Immun Ageing 9:5. 2012
  6. doi request reprint Antioxidants as antidepressants: fact or fiction?
    Giovanni Scapagnini
    Department of Medicine and Health Sciences, University of Molise, Campobasso, Italy
    CNS Drugs 26:477-90. 2012
  7. pmc Extending healthy ageing: nutrient sensitive pathway and centenarian population
    Sergio Davinelli
    Department of Health Sciences, University of Molise, Campobasso, Italy
    Immun Ageing 9:9. 2012
  8. pmc Curcumin, inflammation, ageing and age-related diseases
    E Sikora
    Laboratory of Molecular Bases of Ageing, Nencki Institute of Experimental Biology, PAS, Warsaw, Poland
    Immun Ageing 7:1. 2010
  9. ncbi request reprint Therapeutic potential of dietary polyphenols against brain ageing and neurodegenerative disorders
    Giovanni Scapagnini
    Department of Health Sciences, University of Molise, Campobasso, Italy
    Adv Exp Med Biol 698:27-35. 2010
  10. ncbi request reprint Therapeutic Potential of Dietary Polyphenols against Brain Ageing and Neurodegenerative Disorders
    Giovanni Scapagnini
    Department of Health Sciences, University of Molise, Campobasso, Italy
    Adv Exp Med Biol 698:27-35. 2011

Collaborators

Detail Information

Publications25

  1. pmc Enhancement of mitochondrial biogenesis with polyphenols: combined effects of resveratrol and equol in human endothelial cells
    Sergio Davinelli
    Department of Medicine and Health Sciences, University of Molise, Campobasso 86100, Italy
    Immun Ageing 10:28. 2013
    ..Further studies to discover the molecular details of this crosstalk and to identify new combinations of active compounds affecting the mitochondrial function will be extremely beneficial to prevent mitochondrial decline. ..
  2. doi request reprint Epigenetic nutraceutical diets in Alzheimer's disease
    S Davinelli
    Giovanni Scapagnini, Department of Medicine and Health Sciences, University of Molise, Campobasso 86100, Italy
    J Nutr Health Aging 18:800-5. 2014
    ..Here, we provide a brief overview of the main mechanisms involved in AD, some of which may be epigenetically modulated by bioactive food. ..
  3. pmc Cocoa bioactive compounds: significance and potential for the maintenance of skin health
    Giovanni Scapagnini
    Department of Medicine and Health Sciences, University of Molise, Campobasso 86100, Italy
    Nutrients 6:3202-13. 2014
    ..Moreover, we will summarize in vivo studies showing that bioactive compounds of cocoa may have a positive impact on skin health. ..
  4. pmc Sulfur compounds block MCP-1 production by Mycoplasma fermentans-infected macrophages through NF-κB inhibition
    Francesca Benedetti
    Institute of Human Virology, University of Maryland School of Medicine, Baltimore, MD 21201, USA
    J Transl Med 12:145. 2014
    ..By infecting monocytes/macrophages with Mycoplasma fermentans (M.F.), a well-known pro-inflammatory agent, we evaluated the effects of H2S...
  5. pmc "Positive biology": the centenarian lesson
    Calogero Caruso
    Department of Pathobiology and Medical and Forensic Biotechnologies, University of Palermo, Corso Tukory 211, 90134, Palermo, Italy
    Immun Ageing 9:5. 2012
    ....
  6. doi request reprint Antioxidants as antidepressants: fact or fiction?
    Giovanni Scapagnini
    Department of Medicine and Health Sciences, University of Molise, Campobasso, Italy
    CNS Drugs 26:477-90. 2012
    ..There is an urgent need to develop better tolerated and more effective treatments for depressive disorders and several antioxidant treatments appear promising and deserve further study...
  7. pmc Extending healthy ageing: nutrient sensitive pathway and centenarian population
    Sergio Davinelli
    Department of Health Sciences, University of Molise, Campobasso, Italy
    Immun Ageing 9:9. 2012
    ..Finally, we also discuss the potential role of Nrf2 system in the pro-ageing signaling emphasizing its phytohormetic activation...
  8. pmc Curcumin, inflammation, ageing and age-related diseases
    E Sikora
    Laboratory of Molecular Bases of Ageing, Nencki Institute of Experimental Biology, PAS, Warsaw, Poland
    Immun Ageing 7:1. 2010
    ..In this review we consider the possibility of the spice curcumin, a powerful antioxidant and anti-inflammatory agent possibly capable of improving the health status of the elderly...
  9. ncbi request reprint Therapeutic potential of dietary polyphenols against brain ageing and neurodegenerative disorders
    Giovanni Scapagnini
    Department of Health Sciences, University of Molise, Campobasso, Italy
    Adv Exp Med Biol 698:27-35. 2010
    ..These studies identify a novel class of compounds that could be used for therapeutic purposes as preventive agents against the acute neurodegenerative conditions that affect many in the world's increasingly ageing population...
  10. ncbi request reprint Therapeutic Potential of Dietary Polyphenols against Brain Ageing and Neurodegenerative Disorders
    Giovanni Scapagnini
    Department of Health Sciences, University of Molise, Campobasso, Italy
    Adv Exp Med Biol 698:27-35. 2011
    ..These studies identify a novel class of compounds that could be used for therapeutic purposes as preventive agents against the acute neurodegenerative conditions that affect many in the world's increasingly ageing population...
  11. pmc The "Alzheimer's disease signature": potential perspectives for novel biomarkers
    Sergio Davinelli
    Department of Health Sciences, University of Molise, Campobasso, Italy
    Immun Ageing 8:7. 2011
    ..We also discuss the latest and most significant results that will help to define a specific disease signature whose validity might be clinically relevant for future AD diagnosis...
  12. doi request reprint Modulation of Nrf2/ARE pathway by food polyphenols: a nutritional neuroprotective strategy for cognitive and neurodegenerative disorders
    Giovanni Scapagnini
    Department of Health Sciences, University of Molise, Campobasso, Italy
    Mol Neurobiol 44:192-201. 2011
    ..These studies identify a novel class of compounds that could be used for therapeutic purposes as preventive agents against cognitive decline...
  13. pmc Pleiotropic protective effects of phytochemicals in Alzheimer's disease
    Sergio Davinelli
    Clinical Biochemistry and Clinical Molecular Biology Laboratory, Department of Health Sciences, University of Molise, 86100 Campobasso, Italy
    Oxid Med Cell Longev 2012:386527. 2012
    ..We will focus on specific molecular targets of these selected phytochemical compounds highlighting the correlations between their neuroprotective functions and their potential therapeutic value in AD...
  14. ncbi request reprint The major green tea polyphenol, (-)-epigallocatechin-3-gallate, induces heme oxygenase in rat neurons and acts as an effective neuroprotective agent against oxidative stress
    Loriana Romeo
    SPES Dipartimento di Scienze per la Salute, Facolta di Medicina, Universita del Molise, via DeSanctis, Campobasso, Italy
    J Am Coll Nutr 28:492S-499S. 2009
    ..Recently, green tea catechins have received much attention, as they can facilitate a number of antioxidative mechanisms and improve glycemic control...
  15. ncbi request reprint Synergistic effect of L-Carnosine and EGCG in the prevention of physiological brain aging
    Sergio Davinelli
    Department of Medicine and Health Sciences, University of Molise, 86100 Campobasso, Italy
    Curr Pharm Des 19:2722-7. 2013
    ..Our results indicate that the combined administration of EGCG and L-Carnosine would benefit the treatment and prevention of neurodegenerative diseases by reducing the neuronal damage caused by oxidative stress...
  16. pmc Dietary Phytochemicals in Neuroimmunoaging: A New Therapeutic Possibility for Humans?
    Graziamaria Corbi
    Department of Medicine and Health Sciences, University of Molise Campobasso, Italy
    Front Pharmacol 7:364. 2016
    ....
  17. ncbi request reprint Genetic risk factors and candidate biomarkers for Alzheimer's disease
    Giovanni Scapagnini
    Department of Health Sciences, University of Molise, Campobasso, Italy
    Front Biosci (Schol Ed) 2:616-22. 2010
    ..This review will elaborate on the available selection of genetic and biochemical biomarkers for AD, with a particular reference to those linked to inflammation and oxidative stress...
  18. pmc Serum Levels of Acyl-Carnitines along the Continuum from Normal to Alzheimer's Dementia
    Adriana Cristofano
    Centre for Research and Training in Medicine for Aging, Department of Medicine and Health Sciences Vincenzo Tiberio, University of Molise, Campobasso, Italy
    PLoS ONE 11:e0155694. 2016
    ..However, further validation on a larger number of samples in a longitudinal study is needed before application to clinical practice. ..
  19. pmc Dietary phytochemicals and neuro-inflammaging: from mechanistic insights to translational challenges
    Sergio Davinelli
    Department of Medicine and Health Sciences, School of Medicine, University of Molise, Campobasso, Italy
    Immun Ageing 13:16. 2016
    ....
  20. doi request reprint Influence of equol and resveratrol supplementation on health-related quality of life in menopausal women: A randomized, placebo-controlled study
    Sergio Davinelli
    Department of Medicine and Health Sciences V Tiberio, University of Molise, Campobasso, Italy Electronic address
    Maturitas 96:77-83. 2017
    ..This study was designed to evaluate the effects of equol and resveratrol supplementation on health-related quality of life (HRQoL) in otherwise healthy menopausal women with hot flashes, anxiety and depressive symptoms...
  21. pmc Muscle uncoupling protein 3 expression is unchanged by chronic ephedrine/caffeine treatment: results of a double blind, randomised clinical trial in morbidly obese females
    Renata Bracale
    Department of Medicine and Health Sciences, University of Molise, Campobasso, Italy
    PLoS ONE 9:e98244. 2014
    ..Our study provides evidence that 4-week EC administration resulted in a pronounced thermogenic effect not related to muscle UCP3 gene expression and weight loss in morbidly obese females under controlled conditions...
  22. doi request reprint Polyphenols: a Promising Nutritional Approach to Prevent or Reduce the Progression of Prehypertension
    Sergio Davinelli
    Department of Medicine and Health Sciences, University of Molise, Via De Sanctis snc, 86100, Campobasso, Italy
    High Blood Press Cardiovasc Prev 23:197-202. 2016
    ..The purpose of this article is to discuss the potential benefits of dietary polyphenols as a promising and effective nutritional strategy for the management of prehypertension. ..
  23. doi request reprint A Randomized Clinical Trial Evaluating the Efficacy of an Anthocyanin-Maqui Berry Extract (Delphinol®) on Oxidative Stress Biomarkers
    Sergio Davinelli
    a Department of Medicine and Health Sciences, University of Molise, Campobasso, Italy
    J Am Coll Nutr 34:28-33. 2015
    ....
  24. ncbi request reprint Biomarkes of aging
    Sonya Vasto
    Department of Health Sciences, University of Molise, Campobasso, Italy
    Front Biosci (Schol Ed) 2:392-402. 2010
    ..However, this kind of knowledge is useful to anti-ageing strategies aimed to slow ageing and to postpone death by preventing infectious diseases and delaying the onset of age-related diseases...
  25. ncbi request reprint Role of sirtuins, calorie restriction and physical activity in aging
    Graziamaria Corbi
    Department of Health Sciences, Faculty of Medicine and Surgery, University of Molise, via Giovanni Paolo II Localita Tappino, 86100 Campobasso, Italy
    Front Biosci (Elite Ed) 4:768-78. 2012
    ..However, in aged rats a moderate prolonged exercise training is able to induce increase in SIRT1 activity, suggesting that this tool could counteract age-related dysfunctions...