Khawla Al-Kuraya

Summary

Affiliation: King Faisal Specialist Hospital and Research Centre
Country: Saudi Arabia

Publications

  1. ncbi request reprint Colorectal carcinoma from Saudi Arabia. Analysis of MLH-1, MSH-2 and p53 genes by immunohistochemistry and tissue microarray analysis
    Khawla S Al-Kuraya
    Research Research Centre, King Faisal Specialist Hospital, Riyadh, Kingdom of Saudi Arabia
    Saudi Med J 27:323-8. 2006
  2. pmc A very low incidence of BRAF mutations in Middle Eastern colorectal carcinoma
    Abdul K Siraj
    Human Cancer Genomic Research, Research Center, King Faisal Specialist Hospital and Research Center, MBC 98 16, P, O, Box 3354 Riyadh 11211, Saudi Arabia
    Mol Cancer 13:168. 2014
  3. pmc Phosphorylated IκBα predicts poor prognosis in activated B-cell lymphoma and its inhibition with thymoquinone induces apoptosis via ROS release
    Azhar R Hussain
    Human Cancer Genomic Research, Research Center, King Faisal Specialist Hospital and Research Center, Riyadh, Saudi Arabia
    PLoS ONE 8:e60540. 2013
  4. pmc Resveratrol suppresses constitutive activation of AKT via generation of ROS and induces apoptosis in diffuse large B cell lymphoma cell lines
    Azhar R Hussain
    Human Cancer Genomic Research, King Faisal Specialist Hospital and Research Center, Riyadh, Saudi Arabia
    PLoS ONE 6:e24703. 2011
  5. ncbi request reprint In-situ hybridization as a molecular tool in cancer diagnosis and treatment
    Z Jehan
    Human Cancer Genomic Research, Research Center at KFNCCC, King Faisal Specialist Hospital and Research Centre, MBC 98 16, P O Box 3354, Riyadh 11211, Saudi Arabia
    Curr Med Chem 19:3730-8. 2012
  6. pmc Overexpression of FoxM1 offers a promising therapeutic target in diffuse large B-cell lymphoma
    Shahab Uddin
    Human Cancer Genomic Research, King Faisal Specialist Hospital and Research, Riyadh 11211 Saudi Arabia
    Haematologica 97:1092-100. 2012
  7. ncbi request reprint Wingless signaling pathway family relation to colon cancer. Have we come full circle?
    Khawla S Al-Kuraya
    Biological Repository Centre, King Faisal Specialist Hospital and Research Centre, MBC 98 16, PO Box 3354, Riyadh 11211, Kingdom of Saudi Arabia
    Saudi Med J 26:19-23. 2005
  8. ncbi request reprint Epigenetic changes and their clinical relevance in Saudi diffuse large B-cell lymphoma. A molecular and tissue microarray analysis of 100 cases
    Khawla S Al-Kuraya
    Research Centre, King Faisal Specialist Hospital, MBC 98 16, PO Box 3354, Riyadh 11211, Kingdom of Saudi Arabia
    Saudi Med J 26:1099-103. 2005
  9. pmc HER2, TOP2A, CCND1, EGFR and C-MYC oncogene amplification in colorectal cancer
    Khawla Al-Kuraya
    Department of Human Cancer Genomic Research, Research Centre at King Faisal Specialist Hospital and Research Centre, Riyadh, Saudi Arabia
    J Clin Pathol 60:768-72. 2007
  10. doi request reprint FoxM1 and its association with matrix metalloproteinases (MMP) signaling pathway in papillary thyroid carcinoma
    Maqbool Ahmed
    Human Cancer Genomic Research, King Faisal Specialist Hospital and Research Centre, MBC 98 16, P O Box 3354, Riyadh 11211, Saudi Arabia
    J Clin Endocrinol Metab 97:E1-E13. 2012

Collaborators

Detail Information

Publications27

  1. ncbi request reprint Colorectal carcinoma from Saudi Arabia. Analysis of MLH-1, MSH-2 and p53 genes by immunohistochemistry and tissue microarray analysis
    Khawla S Al-Kuraya
    Research Research Centre, King Faisal Specialist Hospital, Riyadh, Kingdom of Saudi Arabia
    Saudi Med J 27:323-8. 2006
    ..To document the incidence and role of p53 and DNA mismatch repair proteins in colorectal carcinomas, and to evaluate the relative frequency of major molecular pathways in colorectal cancers from Saudi Arabia...
  2. pmc A very low incidence of BRAF mutations in Middle Eastern colorectal carcinoma
    Abdul K Siraj
    Human Cancer Genomic Research, Research Center, King Faisal Specialist Hospital and Research Center, MBC 98 16, P, O, Box 3354 Riyadh 11211, Saudi Arabia
    Mol Cancer 13:168. 2014
    ..Due to the lack of data on the true incidence of BRAF mutations in Saudi Arabia, we sought to analyze the incidence of BRAF mutations in this ethnic group...
  3. pmc Phosphorylated IκBα predicts poor prognosis in activated B-cell lymphoma and its inhibition with thymoquinone induces apoptosis via ROS release
    Azhar R Hussain
    Human Cancer Genomic Research, Research Center, King Faisal Specialist Hospital and Research Center, Riyadh, Saudi Arabia
    PLoS ONE 8:e60540. 2013
    ..These data show that p-IκBα can be used as a prognostic marker and target for therapy in this aggressive sub-type of DLBCL and TQ may play an important role in the management of DLBCL in the future...
  4. pmc Resveratrol suppresses constitutive activation of AKT via generation of ROS and induces apoptosis in diffuse large B cell lymphoma cell lines
    Azhar R Hussain
    Human Cancer Genomic Research, King Faisal Specialist Hospital and Research Center, Riyadh, Saudi Arabia
    PLoS ONE 6:e24703. 2011
    ....
  5. ncbi request reprint In-situ hybridization as a molecular tool in cancer diagnosis and treatment
    Z Jehan
    Human Cancer Genomic Research, Research Center at KFNCCC, King Faisal Specialist Hospital and Research Centre, MBC 98 16, P O Box 3354, Riyadh 11211, Saudi Arabia
    Curr Med Chem 19:3730-8. 2012
    ..This article will discuss the extensive application of FISH in diagnosis, prognosis and therapeutic monitoring of cancer...
  6. pmc Overexpression of FoxM1 offers a promising therapeutic target in diffuse large B-cell lymphoma
    Shahab Uddin
    Human Cancer Genomic Research, King Faisal Specialist Hospital and Research, Riyadh 11211 Saudi Arabia
    Haematologica 97:1092-100. 2012
    ..However, its role in lymphoid malignancies has not been fully clarified. We, therefore, investigated the role of FoxM1 expression in a large cohort of diffuse large B-cell lymphoma samples and panel of cell lines...
  7. ncbi request reprint Wingless signaling pathway family relation to colon cancer. Have we come full circle?
    Khawla S Al-Kuraya
    Biological Repository Centre, King Faisal Specialist Hospital and Research Centre, MBC 98 16, PO Box 3354, Riyadh 11211, Kingdom of Saudi Arabia
    Saudi Med J 26:19-23. 2005
    ..This review summarizes the role of the wingless signaling pathway genes including APC and MMR genes in the development of CRC...
  8. ncbi request reprint Epigenetic changes and their clinical relevance in Saudi diffuse large B-cell lymphoma. A molecular and tissue microarray analysis of 100 cases
    Khawla S Al-Kuraya
    Research Centre, King Faisal Specialist Hospital, MBC 98 16, PO Box 3354, Riyadh 11211, Kingdom of Saudi Arabia
    Saudi Med J 26:1099-103. 2005
    ..We explored the aberrant promoter methylation of MGMT in Saudi diffuse large B-cell lymphoma and to investigate MGMT hypermethylation has an effect on patient's overall survival...
  9. pmc HER2, TOP2A, CCND1, EGFR and C-MYC oncogene amplification in colorectal cancer
    Khawla Al-Kuraya
    Department of Human Cancer Genomic Research, Research Centre at King Faisal Specialist Hospital and Research Centre, Riyadh, Saudi Arabia
    J Clin Pathol 60:768-72. 2007
    ..In this study, the molecular differences between the incidences of colorectal carcinoma in Saudi and Swiss populations are investigated...
  10. doi request reprint FoxM1 and its association with matrix metalloproteinases (MMP) signaling pathway in papillary thyroid carcinoma
    Maqbool Ahmed
    Human Cancer Genomic Research, King Faisal Specialist Hospital and Research Centre, MBC 98 16, P O Box 3354, Riyadh 11211, Saudi Arabia
    J Clin Endocrinol Metab 97:E1-E13. 2012
    ..FoxM1 has also been shown to be associated with matrix metalloproteinases (MMP) in various cancers. However, little is known about its function in papillary thyroid carcinoma (PTC)...
  11. pmc Overexpression of leptin receptor predicts an unfavorable outcome in Middle Eastern ovarian cancer
    Shahab Uddin
    Department of Human Cancer Genomic Research, Research Center, Department of Pathology, King Faisal Specialist Hospital and Research Center, Riyadh, Saudi Arabia
    Mol Cancer 8:74. 2009
    ..This study was design to investigate the prevalence of leptin and Ob-R in Middle Eastern epithelial ovarian cancer (EOC) and to analyze the role of leptin and the mechanisms under its action in EOC tissue sample and cell lines...
  12. pmc PIK3CA alterations in Middle Eastern ovarian cancers
    Jehad Abubaker
    Department of Human Cancer Genomic Research, Research Center, King Faisal Specialist Hospital and Research Center, Riyadh, Saudi Arabia
    Mol Cancer 8:51. 2009
    ..Therefore, we investigated PI3K/AKT genetic alterations such as PIK3CA amplification, PIK3CA mutation, PTEN protein loss and their relationships with various clinicopathological characteristics in 156 EOCs...
  13. pmc Prognostic significance of TRAIL death receptors in Middle Eastern colorectal carcinomas and their correlation to oncogenic KRAS alterations
    Prashant Bavi
    Department of Human Cancer Genomic Research, MBC 98 16, Research Centre at KFNCCC, King Faisal Specialist Hospital and Research Centre, PO Box 3354, Riyadh 11211, Kingdom of Saudi Arabia
    Mol Cancer 9:203. 2010
    ..Expression of TRAIL receptors is higher in colorectal carcinoma (CRC) as compared to normal colorectal mucosa and targeted therapy with TRAIL leads to preferential killing of tumor cells sparing normal cells...
  14. doi request reprint Polymorphisms of drug-metabolizing enzymes CYP1A1, GSTT and GSTP contribute to the development of diffuse large B-cell lymphoma risk in the Saudi Arabian population
    Fouad Al-Dayel
    Department of Pathology and Laboratory Medicine, King Faisal Specialist Hospital and Research Centre, Riyadh, Saudi Arabia
    Leuk Lymphoma 49:122-9. 2008
    ..Our findings suggest that polymorphisms of xenobiotic metabolizing enzyme genes may modify the individual susceptibility to develop DLBCL in Saudi Arabian population...
  15. ncbi request reprint Genetic polymorphisms of methylenetetrahydrofolate reductase and promoter methylation of MGMT and FHIT genes in diffuse large B cell lymphoma risk in Middle East
    Abdul K Siraj
    Department of Human Cancer Genomic Research Centre, King Fahad National Center for Children s Cancer and Research, Riyadh, Saudi Arabia
    Ann Hematol 86:887-95. 2007
    ..Additionally, the results indicated that MTHFR variants were not related to MGMT or FHIT hypermethylation in DLBCL...
  16. ncbi request reprint Predominance of high-grade pathway in breast cancer development of Middle East women
    Khawla Al-Kuraya
    King Faisal Specialist Hospital and Research Centre, Riyadh, Saudi Arabia
    Mod Pathol 18:891-7. 2005
    ..These observations suggest that a difference in genetic susceptibility and/or lifestyle between Saudi and Swiss women has a substantial and much higher than expected impact on the risk of low-grade breast cancer...
  17. ncbi request reprint High epidermal growth factor receptor amplification rate but low mutation frequency in Middle East lung cancer population
    Khawla Al-Kuraya
    King Faisal Specialist Hospital and Research Centre, Riyadh, Kingdom of Saudi Arabia
    Hum Pathol 37:453-7. 2006
    ..The remarkable high rate of EGFR gene amplifications could potentially facilitate studies on the predictive role of gene copy number changes for response to anti-EGFR therapies in Middle East patient sets...
  18. ncbi request reprint High frequency and strong prognostic relevance of O6-methylguanine DNA methyltransferase silencing in diffuse large B-cell lymphomas from the Middle East
    Khawla Al-Kuraya
    King Faisal Specialist Hospital and Research Centre, Riyadh, Kingdom of Saudi Arabia
    Hum Pathol 37:742-8. 2006
    ..These results provide evidence for molecular differences between Saudi Arabian and Western DLBCL...
  19. ncbi request reprint Prevalence of fragile histidine triad expression in tumors from saudi arabia: a tissue microarray analysis
    Prashant Bavi
    Research Centre at KFNCCC and R, King Faisal Specialist Hospital and Research Centre, MBC 98 16, P O Box 3354, Riyadh 11211, Saudi Arabia
    Cancer Epidemiol Biomarkers Prev 15:1708-18. 2006
    ..It encodes the most active common human chromosomal fragile region, FRA3B. We studied the prevalence of loss of FHIT expression in various tumors and correlated its loss with various clinicopathologic features...
  20. doi request reprint Demethylation of TMS1 gene sensitizes thyroid cancer cells to TRAIL-induced apoptosis
    Abdul K Siraj
    Department of Human Cancer Genomics, King Faisal Specialist Hospital and Research Center, Riyadh, Saudi Arabia
    J Clin Endocrinol Metab 96:E215-24. 2011
    ..However, its methylation status has not been investigated in thyroid cancer. Therefore, we studied the methylation of TMS1 and its functional consequence in thyroid cancer...
  21. ncbi request reprint Prognostic relevance of gene amplifications and coamplifications in breast cancer
    Khawla Al-Kuraya
    King Faisal Specialist Hospital and Research Centre, Riyadh, Saudi Arabia
    Cancer Res 64:8534-40. 2004
    ..In conclusion, these data support a major prognostic impact of genomic instability as determined by a broad gene amplification survey in breast cancer...
  22. pmc Polymorphisms of selected xenobiotic genes contribute to the development of papillary thyroid cancer susceptibility in Middle Eastern population
    Abdul K Siraj
    Cancer Genomics, Research Centre, King Fahad National Center for Children s Cancer and Research, King Faisal Specialist Hospital and Research Centre, Riyadh, Saudi Arabia
    BMC Med Genet 9:61. 2008
    ..To evaluate the role of genetic polymorphisms of xenobiotic genes in thyroid cancer, we conducted a hospital-based case-control study in Saudi population...
  23. ncbi request reprint Epstein-Barr virus infection is not the sole cause of high prevalence for Hodgkin's lymphoma in Saudi Arabia
    Khawla Al-Kuraya
    King Faisal Specialist Hospital and Research Centre, Riyadh, Kingdom of Saudi Arabia
    Leuk Lymphoma 47:707-13. 2006
    ..This would be consistent with a major role of genetic susceptibility genes for HL in these populations. The Saudi Arabian population, with high consanguinity and large families, would prove ideal for identifying HL susceptibility genes...
  24. pmc Differential Clinicopathological Risk and Prognosis of Major Papillary Thyroid Cancer Variants
    Xiaoguang Shi
    Laboratory for Cellular and Molecular Thyroid Research, Division of Endocrinology, Diabetes and Metabolism, Department of Medicine X Shi, R L, X Shen, D T, M X, Johns Hopkins University School of Medicine, Baltimore, MD 21287 Department of Surgery, Division of Pathology F B, R G, 56126 Pisa, Italy The Endocrine Institute and The Liaoning Provincial Key Laboratory of Endocrine Diseases, Department of Endocrinology and Metabolism H G, Z S, W T, The First Hospital of China Medical University, Shenyang, Liaoning Province 110001, China Endocrine Surgery T J M, University Medical Center, Johannes Gutenberg University Mainz, 55101 Mainz, Germany Human Cancer Genomic Research K A K, Research Centre, King Faisal Specialist Hospital and Research Centre, Riyadh 12713, Kingdom of Saudi Arabia Fondazione Instituto di Ricovero e Cura a Carattere Scientifico IRCCS Ca Granda Policlinico, Milan, and Department of Pathophysiology and Transplantation L E, C C, University of Milan, 20122 Milan Italy Endocrine Oncology Branch, Center for Cancer Research E K, National Cancer Institute, National Institutes of Health, UK
    J Clin Endocrinol Metab 101:264-74. 2016
    ..Individualized management, incorporating papillary thyroid cancer (PTC) variant-specific risk, is conceivably a useful treatment strategy for PTC, which awaits comprehensive data demonstrating differential risks of PTC variants to support...