Hassan Y Aboul-Enein

Summary

Affiliation: King Faisal Specialist Hospital and Research Centre
Country: Saudi Arabia

Publications

  1. ncbi request reprint HPLC analysis of S-adenosyl-L-methionine in pharmaceutical formulations
    H Y Aboul-Enein
    Pharmaceutical Analysis Laboratory, Biological and Medical Research Department, King Faisal Specialist Hospital and Research Centre, Riyadh, Saudi Arabia
    Pharmazie 56:626-8. 2001
  2. ncbi request reprint Normal phase chiral HPLC of methylphenidate: comparison of different polysaccharide-based chiral stationary phases
    Hassan Y Aboul-Enein
    Pharmaceutical Analysis Laboratory, Biological and Medical Research Department MBC 03, King Faisal Specialist Hospital and Research Center, P O Box 3354, Riyadh 11211, Saudi Arabia
    Chirality 14:47-50. 2002
  3. ncbi request reprint Enantiomeric separation of glutethimide derivatives using a Ceramospher RU-2 column
    H Y Aboul-Enein
    Pharmaceutical Analysis Laboratory, Biological and Medical Research Department MBC 03, King Faisal Specialist Hospital and Research Center, Riyadh, Saudi Arabia
    Pharmazie 59:833-5. 2004
  4. ncbi request reprint A modified HPLC method for the determination of ochratoxin A by fluorescence detection
    Hassan Y Aboul-Enein
    Pharmaceutical Analysis Laboratory, Biological and Medical Research Department, MBC 03 65, King Specialist Hospital and Research Centre, PO Box 3354, Riyadh 11211, Saudi Arabia
    Biomed Chromatogr 16:470-4. 2002
  5. ncbi request reprint Effect of psoralens on Fenton-like reaction generating reactive oxygen species
    Hassan Y Aboul-Enein
    Pharmaceutical Analysis Laboratory, Biological and Medical Research Department MBC 03 65, King Faisal Specialist Hospital and Research Centre, P O Box 3354, Riyadh 11211, Saudi Arabia
    Biopolymers 72:59-68. 2003
  6. ncbi request reprint Thermodynamic study of the enantiomeric resolution of flurbiprofen by HPLC using Chiralpak AD-RH column
    H Y Aboul-Enein
    Pharmaceutical Analysis Laboratory, Biological and Medical Research Department MBC 03, King Faisal Specialist Hospital and Research Center, Riyadh, Saudi Arabia
    Pharmazie 57:682-5. 2002
  7. ncbi request reprint Effect of acidity on the enantiomeric resolution of thyroxine and tocainide by HPLC on a (+)-(18-crown-6)-2,3,11,12-tetracarboxylic acid column
    Hassan Y Aboul-Enein
    Biological and Medical Research Department MBC 03, King Faisal Specialist Hospital and Research Center, PO Box 3354, Riyadh 11211, Saudi Arabia
    J Biochem Biophys Methods 54:407-13. 2002
  8. ncbi request reprint A validated method development for ketoprofen by a flow-injection analysis with UV-detection and its application to pharmaceutical formulations
    Hassan Y Aboul-Enein
    Biological and Medical Research Department MBC 03 65, Pharmaceutical Analysis Laboratory, King Faisal Specialist Hospital and Research Centre, PO Box 3354, Riyadh 11211, Saudi Arabia
    Farmaco 58:419-22. 2003
  9. ncbi request reprint Thin layer chromatographic resolution of some 2-arylpropionic acid enantiomers using L-(-)-serine, L-(-)-threonine and a mixture of L-(-)-serine and L-(-)-threonine-impregnated silica gel as stationary phases
    Hassan Y Aboul-Enein
    Pharmaceutical Analysis Laboratory, Biological and Medical Research Department MBC 03 65, King Faisal Specialist Hospital and Research Centre, PO Box 3354, Riyadh 11211, Saudi Arabia
    Biomed Chromatogr 17:325-34. 2003
  10. ncbi request reprint Enantiomeric resolution of some 2-arylpropionic acids using L-(-)-serine-impregnated silica as stationary phase by thin layer chromatography
    Hassan Y Aboul-Enein
    Pharmaceutical Analysis Laboratory, Biological and Medical Research Department MBC 03 65, King Faisal Specialist Hospital and Research Centre, P O Box 3354, Riyadh 11211, Saudi Arabia
    J Pharm Biomed Anal 32:1055-9. 2003

Collaborators

Detail Information

Publications56

  1. ncbi request reprint HPLC analysis of S-adenosyl-L-methionine in pharmaceutical formulations
    H Y Aboul-Enein
    Pharmaceutical Analysis Laboratory, Biological and Medical Research Department, King Faisal Specialist Hospital and Research Centre, Riyadh, Saudi Arabia
    Pharmazie 56:626-8. 2001
    ..0-99.9%. The procedure was also suitable to check the stability of S-adenosyl-L-methionine in solution at room temperature...
  2. ncbi request reprint Normal phase chiral HPLC of methylphenidate: comparison of different polysaccharide-based chiral stationary phases
    Hassan Y Aboul-Enein
    Pharmaceutical Analysis Laboratory, Biological and Medical Research Department MBC 03, King Faisal Specialist Hospital and Research Center, P O Box 3354, Riyadh 11211, Saudi Arabia
    Chirality 14:47-50. 2002
    ..2 mM benzoic acid in mobile phase), and Chiralcel OB (containing 0.2 mM phenol in mobile phase), respectively. The role of benzoic acid and phenol as mobile phase additives is discussed...
  3. ncbi request reprint Enantiomeric separation of glutethimide derivatives using a Ceramospher RU-2 column
    H Y Aboul-Enein
    Pharmaceutical Analysis Laboratory, Biological and Medical Research Department MBC 03, King Faisal Specialist Hospital and Research Center, Riyadh, Saudi Arabia
    Pharmazie 59:833-5. 2004
    ..The possible chiral mechanism was the formation of transient diastereomeric intermediates between the enantiomers and the chiral selector (1,10-phenanthroline) ruthenium II complex which was stabilized by pi-pi interactions...
  4. ncbi request reprint A modified HPLC method for the determination of ochratoxin A by fluorescence detection
    Hassan Y Aboul-Enein
    Pharmaceutical Analysis Laboratory, Biological and Medical Research Department, MBC 03 65, King Specialist Hospital and Research Centre, PO Box 3354, Riyadh 11211, Saudi Arabia
    Biomed Chromatogr 16:470-4. 2002
    ..Recovery studies were 81.2 +/- 1.9 (SD). The method was applied for analysis of OTA in wheat, corn, red pepper, cheese and wine. The proposed method can be used for the routine analysis of OTA in food and animal feed...
  5. ncbi request reprint Effect of psoralens on Fenton-like reaction generating reactive oxygen species
    Hassan Y Aboul-Enein
    Pharmaceutical Analysis Laboratory, Biological and Medical Research Department MBC 03 65, King Faisal Specialist Hospital and Research Centre, P O Box 3354, Riyadh 11211, Saudi Arabia
    Biopolymers 72:59-68. 2003
    ..Measurements were done using a deoxyribose assay, the CL method, and spin-trapping with 5,5-dimethyl-1-pyrroline-N-oxide and 2,2,6,6-tetramethylpiperidine combined with electron spin resonance spectroscopy and spectrophotometry methods...
  6. ncbi request reprint Thermodynamic study of the enantiomeric resolution of flurbiprofen by HPLC using Chiralpak AD-RH column
    H Y Aboul-Enein
    Pharmaceutical Analysis Laboratory, Biological and Medical Research Department MBC 03, King Faisal Specialist Hospital and Research Center, Riyadh, Saudi Arabia
    Pharmazie 57:682-5. 2002
    ..The enantio-resolution was found to be exothermic in nature. Attempts have been made to explain the mechanism of chiral resolution of flurbiprofen on the Chiralpak AD-RH column...
  7. ncbi request reprint Effect of acidity on the enantiomeric resolution of thyroxine and tocainide by HPLC on a (+)-(18-crown-6)-2,3,11,12-tetracarboxylic acid column
    Hassan Y Aboul-Enein
    Biological and Medical Research Department MBC 03, King Faisal Specialist Hospital and Research Center, PO Box 3354, Riyadh 11211, Saudi Arabia
    J Biochem Biophys Methods 54:407-13. 2002
    ..Detection was at 220 nm for both drugs. The values of alpha and Rs were 2.08-3.11 and 1.00-2.60, respectively, for thyroxine while the values of alpha and Rs were 1.13-1.26 and 0.10-1.30, respectively, for tocainide...
  8. ncbi request reprint A validated method development for ketoprofen by a flow-injection analysis with UV-detection and its application to pharmaceutical formulations
    Hassan Y Aboul-Enein
    Biological and Medical Research Department MBC 03 65, Pharmaceutical Analysis Laboratory, King Faisal Specialist Hospital and Research Centre, PO Box 3354, Riyadh 11211, Saudi Arabia
    Farmaco 58:419-22. 2003
    ..The recoveries were 102.75% for peak area and 98.42% for peak height. The proposed method is fast, precise, sensitive and easy to use for the determination of ketoprofen in pharmaceuticals...
  9. ncbi request reprint Thin layer chromatographic resolution of some 2-arylpropionic acid enantiomers using L-(-)-serine, L-(-)-threonine and a mixture of L-(-)-serine and L-(-)-threonine-impregnated silica gel as stationary phases
    Hassan Y Aboul-Enein
    Pharmaceutical Analysis Laboratory, Biological and Medical Research Department MBC 03 65, King Faisal Specialist Hospital and Research Centre, PO Box 3354, Riyadh 11211, Saudi Arabia
    Biomed Chromatogr 17:325-34. 2003
    ..25 and 0.5 micro g/mL for all racemic compounds investigated. The effect of temperature, pH and concentration of the impregnating chiral selectors on resolution has been studied...
  10. ncbi request reprint Enantiomeric resolution of some 2-arylpropionic acids using L-(-)-serine-impregnated silica as stationary phase by thin layer chromatography
    Hassan Y Aboul-Enein
    Pharmaceutical Analysis Laboratory, Biological and Medical Research Department MBC 03 65, King Faisal Specialist Hospital and Research Centre, P O Box 3354, Riyadh 11211, Saudi Arabia
    J Pharm Biomed Anal 32:1055-9. 2003
    ..50 microg/ml. The effect of concentration of the impregnating chiral selector, temperature and pH on resolution has been studied. The procedure was applied successfully to resolve commercial ampoules of ketoprofen dosage formulation...
  11. ncbi request reprint Chemical modification of milk xanthine oxidase with different modifiers
    Hassan Y Aboul-Enein
    Pharmaceutical Analysis Laboratory, Biological and Medical Department MBC 03 65, King Faisal Specialist Hospital and Research Centre, Riyadh, Saudi Arabia
    Prep Biochem Biotechnol 33:173-87. 2003
    ..Moreover, the modifiers induce uptake inhibition of milk XO and appeared to be dependant upon either the concentration or incubation time...
  12. ncbi request reprint Enantioselective determination of arotinolol in human plasma by HPLC using teicoplanin chiral stationary phase
    Hassan Y Aboul-Enein
    Pharmaceutical Analysis Laboratory, Biological and Medical Research Department MBC 03, King Faisal Specialist Hospital and Research Centre, PO Box 3354, Riyadh 11211, Saudi Arabia
    Biomed Chromatogr 17:453-7. 2003
    ..9998. The limit of quantitation (LOQ) and limit of detection (LOD) for each enantiomer in human plasma were 100 and 50 ng/mL (S/N = 3), respectively...
  13. ncbi request reprint Chiral analysis of butaclamol enantiomers in human plasma by HPLC using a macrocyclic antibiotic (vancomycin) chiral stationary phase and solid phase extraction
    Hassan Y Aboul-Enein
    Pharmaceutical Analysis Laboratory, Biological and Medical Research Department MBC 03, King Faisal Specialist Hospital and Research Centre, P O Box 3354, Riyadh 11211, Saudi Arabia
    Chirality 16:147-52. 2004
    ..5-5.8% and between-run accuracies ranged from 2.7-7.7%). The limit of quantitation (LOQ) and limit of detection (LOD) for each enantiomer in human plasma were 100 ng/ml and 50 ng/ml, respectively...
  14. ncbi request reprint High performance liquid chromatographic analysis of dehydroepiandrosterone and its pharmaceutical tablet formulation
    Hassan Y Aboul-Enein
    Pharmaceutical Analysis Laboratory, Biological and Medical Department MBC 03 65, King Faisal Specialist Hospital and Research Centre, PO Box 3354, Riyadh 11211, Saudi Arabia
    Biomed Chromatogr 18:6-9. 2004
    ..The effects of different buffers and alcohols on the retention of DHEA were studied and the role of acetic acid as an organic phase modifier was also investigated...
  15. ncbi request reprint Prooxidant and antioxidant action of 4-(4-phenoxybenzoyl)benzoic acid derivatives
    Hassan Y Aboul-Enein
    Biological and Medical Research Department, MBC 03 65, King Faisal Specialist Hospital and Research Centre, P O Box 3354, Riyadh 11211, Saudi Arabia
    Biopolymers 73:631-9. 2004
    ..These results indicate that PBAD may directly scavenge HO(*) and (1)O(2), but not O(2)(.-). However, the compounds that were examined had prooxidant ability under some reaction conditions...
  16. ncbi request reprint Comparative bioavailability study of two tablet formulations of digoxin
    Hassan Y Aboul-Enein
    Pharmaceutical Analysis Laboratory, Biological and Medical Research Department MBC 03 65, King Faisal Specialist Hospital and Research Centre, Riyadh, Saudi Arabia
    J Immunoassay Immunochem 25:125-33. 2004
    ..The parametric confidence intervals (90%) of the mean values of the pharmacokinetic characteristics (AUC(0-12) and Cmax) for A:B ratio were, in each case, well within the bioequivalence acceptable range of 80-125%...
  17. ncbi request reprint Chiral resolution of some piperidine 2, 6-dione drugs by high performance liquid chromatography on Kromasil CHI-DMB column
    Hassan Y Aboul-Enein
    Biological and Medical Research Department, King Faisal Specialist Hospital and Research Centre, Saudi Arabia
    Arch Pharm (Weinheim) 337:453-6. 2004
    ..The chromatographic parameters are reported. The chiral recognition mechanisms between the analytes and the CSP depend primarily on hydrogen bonding and/or (pi-pi) interactions...
  18. ncbi request reprint Enantiomeric separation of cizolirtine and metabolites on amylose tris (3,5-dimethylphenyl carbamate) chiral stationary phase
    Hassan Y Aboul-Enein
    Pharmaceutical Analysis Laboratory, Biological and Medical Research Department MBC 03 65, King Faisal Specialist Hospital and Research Center, P O Box 3354, Riyadh 11211, Saudi Arabia
    Farmaco 59:743-6. 2004
    ..The values of R(s) of the resolved enantiomers of (+/-)-cizolirtine, (+/-)-cizolirtine-N-oxide, (+/-)-N-desmethylcizolirtine and (+/-)-5(alpha-hydroxybenzyl)-1-methyl pyrazole were 1.20, 0.60, 1.16 and 1.15, respectively...
  19. ncbi request reprint Optimization strategies for HPLC enantioseparation of racemic drugs using polysaccharides and macrocyclic glycopeptide antibiotic chiral stationary phases
    Hassan Y Aboul-Enein
    Biological and Medical Research Department MBC 03, King Faisal Specialist Hospital and Research Center, Riyadh, Saudi Arabia
    Farmaco 57:513-29. 2002
    ..The most important parameters discussed are composition of mobile phase, pH of mobile phase, flow rate, temperature and effect of other parameters...
  20. ncbi request reprint The impact of chirality of the fluorinated volatile inhalation anaesthetics on their clinical applications
    H Y Aboul-Enein
    Bioanalytical and Drug Development Laboratory, Biological and Medical Research Department, MBC 03, King Faisal Specialist Hospital and Research Centre, PO Box 3354, Riyadh 11211, Saudi Arabia
    Biomed Chromatogr 14:213-8. 2000
    ..The racemic switch to a single enantiomer for these fluorinated volatile anaesthetics offers a more effective and safe general anaesthetic...
  21. ncbi request reprint HPLC enantiomeric resolution of novel aromatase inhibitors on cellulose- and amylose-based chiral stationary phases under reversed phase mode
    H Y Aboul-Enein
    Pharmaceutical Analysis Laboratory, Biological and Medical Research Department MBC 03, King Faisal Specialist Hospital and Research Center, Riyadh, Saudi Arabia
    Chirality 12:727-33. 2000
    ..The values of alpha and Rs of the resolved enantiomers of the aromatase inhibitors varied from 1.02-5.63 and 1. 12-6.72, respectively...
  22. ncbi request reprint High-performance liquid chromatographic enantioseparation of drugs containing multiple chiral centers on polysaccharide-type chiral stationary phases
    H Y Aboul-Enein
    Pharmaceutical Analysis Laboratory, Biological and Medical Research Department, King Faisal Specialist Hospital and Research Centre, Riyadh, Saudi Arabia
    J Chromatogr A 906:185-93. 2001
    ..Also, the use of the column-switching technique is demonstrated to achieve the resolution of this type of compounds...
  23. ncbi request reprint Application of thin-layer chromatography in enantiomeric chiral analysis-an overview
    H Y Aboul-Enein
    Bioanalytical and Drug Development Laboratory, Biological and Medical Research Department MBC 03, King Faisal Specialist Hospital and Research Centre, Riyadh 11211, Saudi Arabia
    Biomed Chromatogr 13:531-7. 1999
    ..This review presents an overview of the current successful enantioseparations of drugs by TLC and their potential in the analysis of the drug racemates...
  24. ncbi request reprint HPLC enantiomeric resolution of nebivolol on normal and reversed amylose based chiral phases
    H Y Aboul-Enein
    Pharmaceutical Analysis Laboratory, Biological and Medical Research Department MBC 03, King Faisal Specialist Hospital and Research Centre, Riyadh, Saudi Arabia
    Pharmazie 56:214-6. 2001
    ..38 while on Chiralpak AD-RH these values were 1.41 and 1.38 respectively. The values of Rs for ethanol and 1-propanol were 2.63 and 1.71 on Chiralpak AD and 1.73 and 1.76 on Chiralpak AD-RH respectively...
  25. ncbi request reprint Studies on the effect of alcohols on the chiral discrimination mechanisms of amylose stationary phase on the enantioseparation of nebivolol by HPLC
    H Y Aboul-Enein
    Pharmaceutical Analysis Laboratory, Biological and Medical Research Department MBC 03, King Faisal Specialist Hospital and Research Center, P O Box 3354, 11211, Riyadh, Saudi Arabia
    J Biochem Biophys Methods 48:175-88. 2001
    ....
  26. ncbi request reprint High performance liquid chromatography analysis of 9-(2',3'-dideoxy-2'beta-fluoro-D-threo-penta furanosyl) adenine and its metabolite in human plasma using solid-phase extraction on a polyfluorinated reversed stationary phase
    H Y Aboul-Enein
    Pharmaceutical Analysis Laboratory, Biological and Medical Research Department, King Faisal Specialist Hospital and Research Centre, Riyadh 11211, Saudi Arabia
    Biomed Chromatogr 15:267-70. 2001
    ..F-ddA and F-ddI were monitored by UV-visible detector at 258 and 247 nm, respectively. The recoveries of F-ddA and F-ddI from plasma using a C(18) solid-phase extraction cartridge were 99.2% and 99.7%, respectively...
  27. ncbi request reprint A comparative study of the enantiomeric resolution of several tetralone derivatives on macrocyclic antibiotic chiral stationary phases using HPLC under normal phase mode
    H Y Aboul-Enein
    Pharmaceutical Analysis Laboratory, Biological and Medical Research Department MBC 03, King Faisal Specialist Hospital and Research Center, P O Box 3354, Riyadh 11211, Saudi Arabia
    Arch Pharm (Weinheim) 334:258-60. 2001
    ..00 to 2.50 on Chirobiotic R, 1.00 to 1.95 on Chirobiotic T and 1.00 to 1.60 on Chirobiotic V respectively. The best resolution was achieved on Chirobiotic R column...
  28. ncbi request reprint Quantitative determination of clenbuterol enantiomers in human plasma by high-performance liquid chromatography using the macrocyclic antibiotic chiral stationary phase teicoplanin
    H Y Aboul-Enein
    Bioanalytical and Drug Development Laboratory, Biological and Medical Research Department MBC 03, King Faisal Specialist Hospital and Research Centre, Riyadh 11211, Saudi Arabia
    Biomed Chromatogr 13:520-4. 1999
    ..25, 2 and 10 microM) by calculating the analytical recoveries with a range of 96-104%. The percentage recoveries for the clenbuterol enantiomers were 88.4-102% over the concentration range used. Detailed methodology is presented...
  29. ncbi request reprint Biosensor for enantioselective analysis of S-cilazapril, S-trandolapril, and S-pentopril
    H Y Aboul-Enein
    Department of Biological and Medical Research, King Faisal Specialist Hospital and Research Centre, Riyadh, Saudi Arabia
    Pharm Dev Technol 4:251-5. 1999
    ..The proposed amperometric biosensor that was based on L-AAOD proved reliable in the analysis of the above-mentioned ACE inhibitors and can be used for the quality control of these drugs...
  30. ncbi request reprint Comparison of the chiral resolution of econazole, miconazole, and sulconazole by HPLC using normal-phase amylose CSPs
    H Y Aboul-Enein
    Biological and Medical Research Department, King Faisal Specialist Hospital and Research Center, Riyadh, Saudi Arabia
    Fresenius J Anal Chem 370:951-5. 2001
    ..50 and 1.00 mL min(-1). The alpha values for the resolved enantiomers of econazole, miconazole, and sulconazole on the chiral phases were in the range 1.63 to 1.04; the Rs values varied from 5.68 to 0.32...
  31. ncbi request reprint Comparative study of the enantiomeric resolution of chiral antifungal drugs econazole, miconazole and sulconazole by HPLC on various cellulose chiral columns in normal phase mode
    Hassan Y Aboul-Enein
    Pharmaceutical Analysis Laboratory, Biological and Medical Research Department MBC 03, King Faisal Specialist Hospital and Research Center, P O Box 3354, Riyadh 11211, Saudi Arabia
    J Pharm Biomed Anal 27:441-6. 2002
    ..07 to 2.50 while the values of resolution factor (R(s)) varied from 0.17 to 3.90. The chiral recognition mechanisms between the analytes and the chiral selectors are discussed...
  32. ncbi request reprint Analysis of mebendazole polymorphs by Fourier transform IR spectrometry using chemometric methods
    Hassan Y Aboul-Enein
    Pharmaceutical Analysis Laboratory, Biological and Medical Research Department MBC 03, King Faisal Specialist and Research Centre, P O Box 3354, Riyadh 11211, Saudi Arabia
    Biopolymers 67:56-60. 2002
    ..Two chemometric approaches were used in the data processing: multicomponent partial least squares (PLS2) and principal component regression. The best results were obtained with the PLS2 method...
  33. ncbi request reprint Chemiluminescence accompanying oxidation of bopindolol
    H Y Aboul-Enein
    Biological and Medical Research Department, King Faisal Specialist Hospital and Research Centre, Riyadh, Saudi Arabia
    Biospectroscopy 4:229-33. 1998
    ..The effects of oxygen free radicals scavengers and 1O2 quenchers on the light emission were measured. The obtained results show the electronically excited products of the bopindolol degradation are involved in the oxidation process...
  34. ncbi request reprint Direct enantiomeric resolution of some cardiovascular agents using synthetic polymers imprinted with (-)-S-timolol as chiral stationary phase by thin layer chromatography
    H Y Aboul-Enein
    Pharmaceutical Analysis Laboratory, King Saud University, Riyadh, Saudi Arabia
    Pharmazie 57:169-71. 2002
    ..The method offers a rapid, sensitive and reliable method for quality control for these drugs...
  35. ncbi request reprint Scavenging of reactive oxygen species by novel indolin-2-one and indoline-2-thione derivatives
    Hassan Y Aboul-Enein
    Bioanalytical and Drug Development Laboratory, Biological and Research Centre, P O Box 3354, Riyadh 11211, Saudi Arabia
    Biopolymers 78:171-8. 2005
    ..The results obtained indicated that the examined indoline derivatives had effective activities as radical scavengers and may be considered as an effective source for combating oxidative damage...
  36. ncbi request reprint Scavenging of reactive oxygen species by N-substituted indole-2 and 3-carboxamides
    Hassan Y Aboul-Enein
    Pharmaceutical Analysis Laboratory, Biological and Medical Research Department MBC 03 65, King Faisal Specialist Hospital and Research Centre, PO Box 3354, Riyadh 11211, Saudi Arabia
    Luminescence 19:1-7. 2004
    ..1 mmol/L IDs caused an approximately 13-70% decrease in the CL sum from the O2 (.-) generating system (1 mmol/L). The aim of this paper is to evaluate these indole derivatives as antioxidants and their abilities to scavenge ROS...
  37. ncbi request reprint Applications of polysaccharide-based chiral stationary phases for resolution of different compound classes
    Hassan Y Aboul-Enein
    Pharmaceutical Analysis Laboratory, Biologivval and Medical Research Department MBC 03, King Faisal Specialist Hospital adn Research Center, Riyadh, Saudi Arabia
    Methods Mol Biol 243:183-96. 2004
  38. ncbi request reprint In vitro release and stereoselective disposition of flurbiprofen loaded to poly(D,L-lactide- co-glycolide) nanoparticles in rats
    Mahasen A Radwan
    Department of Clinical Pharmacy, College of Pharmacy, King Saud University, Riyadh, Saudi Arabia
    Chirality 16:119-25. 2004
    ..The present study provides evidence that the sorption of racemic flurbiprofen to PLGA nanoparticles was successful in maintaining (at least up to 12 h) elevated plasma drug concentrations of (+)-S-FL in rats. Chirality 16:119-125, 2004...
  39. ncbi request reprint Enantioseparation of some clinically used drugs by HPLC using cellulose Tris (3,5-dichlorophenylcarbamate) chiral stationary phase
    Imran Ali
    Pharmaceutical Analysis Laboratory, Biological and Medical Research Department MBC 03 65, King Faisal Specialist Hospital and Research Center, PO Box 3354, Riyadh 11211, Saudi Arabia
    Biomed Chromatogr 17:113-7. 2003
    ..The separation factors (alpha) of these drugs ranged from 1.24 to 3.90 while the resolution factors were from 1.05 to 5.0. The chiral recognition mechanisms between the racemates and the chiral selector are discussed...
  40. ncbi request reprint Stereoselective HPLC assay of donepezil enantiomers with UV detection and its application to pharmacokinetics in rats
    Mahasen A Radwan
    Department of Clinical Pharmacy, College of Pharmacy, King Saud University, Riyadh, Saudi Arabia
    J Chromatogr B Analyt Technol Biomed Life Sci 830:114-9. 2006
    ..The assay method also shows good specificity to donepezil enantiomers, and it could be successfully applied to its pharmacokinetic studies and to therapeutic drug monitoring...
  41. ncbi request reprint UPLC-MS/MS determination of doxazosine in human plasma
    Osama Y Al-Dirbashi
    National Laboratory for Newborn Screening, King Faisal Specialist Hospital and Research Centre, P O Box 3354 MBC 03, Riyadh, 11211, Saudi Arabia
    Anal Bioanal Chem 385:1439-43. 2006
    ..02 ng ml(-1) (a signal-to-noise ratio of 3). The method showed satisfactory reproducibility, and the short-term stability of the analyte was assessed. The method was successfully applied to the analysis of DOX in human plasma...
  42. doi request reprint Multi-objective optimization strategy based on desirability functions used for electrophoratic separation and quantification of rosiglitazone and glimepiride in plasma and formulations
    Mohamed M Hefnawy
    Department of Pharmaceutical Chemistry, College of Pharmacy, King Saud University, PO Box 2457, Riyadh 11451, Saudi Arabia
    Drug Test Anal 4:39-47. 2012
    ..07 and 1.14 for intra- and inter-assay precision, respectively. The proposed method has a great value in routine analysis of RSG and GLM for its therapeutic monitoring and pharmacokinetic studies...
  43. doi request reprint Stereoselective HPLC analysis of tertatolol in rat plasma using macrocyclic antibiotic chiral stationary phase
    Mohamed M Hefnawy
    Department of Pharmaceutical Chemistry, College of Pharmacy, King Saud University, Riyadh, Saudi Arabia
    Chirality 23:333-8. 2011
    ..The assay proved to be suitable for therapeutic drug monitoring and chiral quality control for tertatolol formulations by HPLC...
  44. ncbi request reprint A validated LC method for the determination of vesamicol enantiomers in human plasma using vancomycin chiral stationary phase and solid phase extraction
    Mohamed M Hefnawy
    Pharmaceutical Analysis Laboratory, Biological and Medical Research Department MBC 03, King Faisal Specialist Hospital and Research Centre, P O Box 3354, Riyadh 1211 Saudi Arabia
    J Pharm Biomed Anal 35:535-43. 2004
    ..8 to 3.4% and between-run accuracies ranged from 1.7 to 5.0%). The limit of quantitation (LOQ) and limit of detection (LOD) for each enantiomer in human plasma were 1.0 and 0.5 microg/ml (S/N=3), respectively...
  45. ncbi request reprint Application of lipases in kinetic resolution of racemates
    Ashraf Ghanem
    Department of Organic Chemistry, University of Geneva, Geneva, Switzerland
    Chirality 17:1-15. 2005
    ..The literature search dates back to the last five years and covers some comprehensive examples. The main emphasis is on the use of lipases in organic solvents...
  46. doi request reprint Determination of free and total warfarin concentrations in plasma using UPLC MS/MS and its application to a patient samples
    Mahasen A Radwan
    Department of Clinical Pharmacy, King Saud University, Riyadh, Saudi Arabia
    Biomed Chromatogr 26:6-11. 2012
    ..The mean extraction efficiency was 88.6-107.2% of free and total warfarin. The assay was sensitive to follow warfarin pharmacokinetics (free and total) in a patient with resistance to warfarin up to 24 h after a daily dose of warfarin...
  47. ncbi request reprint Optimization of the chiral resolution of baclofen by capillary electrophoresis using beta-cyclodextrin as the chiral selector
    Imran Ali
    Pharmaceutical Analysis Laboratory, Biological and Medical Research Department MBC 03, King Faisal Specialist Hospital and Research Center, Riyadh, Saudi Arabia
    Electrophoresis 24:2064-9. 2003
    ..The values of alpha and R(s) were 1.06 and 1.00, respectively. The electrophoretic conditions were optimized varying the pH and the ionic strength of the BGE, concentrations of beta-cyclodextrin and acetonitrile and the applied voltage...
  48. ncbi request reprint Rapid determination of haloperidol and its metabolites in human plasma by HPLC using monolithic silica column and solid-phase extraction
    Hassan Y Aboul-Enein
    Pharmaceutical Analysis Laboratory, Biological and Medical Research Department MBC 03, King Faisal Specialist Hospital and Research Center, PO Box 3354, Riyadh 11211, Saudi Arabia
    Biomed Chromatogr 20:760-4. 2006
    ..UV detection at 230 nm was used, with the detection limits of these compounds ranging from 2 to 5 ng. The separation factors of all studied compounds were in the range 2.30-16.32, while the resolution factors were from 1.00 to 5.37...
  49. ncbi request reprint A validated chiral HPLC method for the determination of mebeverine HCl enantiomers in pharmaceutical dosage forms and spiked rat plasma
    Mahasen A Radwan
    Department of Clinical Pharmacy, College of Pharmacy, King Saud University, and Centre for Clinical Research, King Faisal Specialist Hospital and Research Centre, Riyadh 11495, Saudi Arabia
    Biomed Chromatogr 20:211-6. 2006
    ..Examples of application to biological samples are also given. Reanalysis of samples several weeks after the initial analysis showed no degradation of mebeverine...
  50. ncbi request reprint Determination of chiral ratio of o,p-DDT and o,p-DDD pesticides on polysaccharides chiral stationary phases by HPLC under reversed-phase mode
    Imran Ali
    Pharmaceutical Analysis Laboratory, Biological and Medical Research Department MBC 03, King Faisal Specialist Hospital and Research Center, P O Box 3354, Riyadh 11211, Saudi Arabia
    Environ Toxicol 17:329-33. 2002
    ..0 mL/min. For both pesticides detection was done at 220 nm. The values for o,p-DDT of alpha and R(s) varied from 1.24 to 2.52 and from 0.80 to 2.47, respectively. The values of alpha and R(s) for o,p-DDD were 1.26 and 0.60, respectively...
  51. ncbi request reprint Chiral liquid chromatography tandem mass spectrometry in the determination of the configuration of glyceric acid in urine of patients with D-glyceric and L-glyceric acidurias
    Mohamed S Rashed
    Department of Biological and Medical Research, Metabolic Screening Laboratory and Bioanalytical and Drug Development Laboratory, King Faisal Specialist Hospital and Research Center, Riyadh 11211, Saudi Arabia
    Biomed Chromatogr 16:191-8. 2002
    ..The method allowed the detection of the glyceric acid stereoisomers in control urine where it was found without exception that L-glyceric was the predominate metabolite...
  52. ncbi request reprint A validated method for analysis of chromium picolinate in nutraceuticals by reversed phase high performance liquid chromatography
    Michael Koll
    Pharmaceutical Analysis Laboratory, Biological and Medical Research Department MBC 03, King Faisal Specialist Hospital and Research Centre, PO Box 3354, Riyadh 11211, Saudi Arabia
    Biomed Chromatogr 19:119-22. 2005
    ..125 to 12.5 microg/mL with a correlation coefficient from 0.999. The limit of detection and limit of quanti fi cation were 0.091 and 0.181 microg/mL, respectively...
  53. ncbi request reprint Evaluation of apoptosis-induction by newly synthesized phthalazine derivatives in breast cancer cell lines
    Jamal M Arif
    Biological and Medical Research, King Faisal Specialist Hospital and Research Center, Riyadh 11211, Saudi Arabia
    Asian Pac J Cancer Prev 7:249-52. 2006
    ..Addition of copper or platinum in the structures generally reduced the apoptotic potential. Possible roles for structure activity relationships are discussed...
  54. ncbi request reprint Rapid liquid chromatography-tandem mass spectrometry method for quantification of ziprasidone in human plasma
    Osama Y Al-Dirbashi
    Department of Genetics, King Faisal Specialist Hospital and Research Centre, PO Box 3354, Riyadh 11211, Saudi Arabia
    Biomed Chromatogr 20:365-8. 2006
    ..1 ng/mL. The method showed satisfactory reproducibility with a coefficient of variation of less than 5%. The method was successfully applied to the analysis of ZIP in spiked human plasma...
  55. ncbi request reprint Speciation of arsenic and chromium metal ions by reversed phase high performance liquid chromatography
    Imran Ali
    Biological and Medical Research Department, King Faisal Specialist Hospital and Research Center, Riyadh, Saudi Arabia
    Chemosphere 48:275-8. 2002
    ..2 respectively. The effect of the acetonitrile percentages was also carried out on the speciation of arsenic only. The relative standard deviation and limit of detection were in the range of 0.01-0.02 and 0.4-1.0 microg/ml respectively...
  56. ncbi request reprint Effect of pyrazoloquinoline derivatives on the growth of Leishmania donovani promastigotes
    Ahmed Al-Qahtani
    Zoology Department, College of Science, King Saud University, Riyadh, Saudi Arabia
    Arch Pharm (Weinheim) 338:484-7. 2005
    ..Some compounds showed less significant activities, while others exhibited little or no activity. Some of these compounds may be potential candidates for future treatment of leishmaniasis...