Gustavo Saposnik

Summary

Publications

  1. pmc Efficacy and safety of non-immersive virtual reality exercising in stroke rehabilitation (EVREST): a randomised, multicentre, single-blind, controlled trial
    Gustavo Saposnik
    Division of Neurology, St Michael s Hospital, University of Toronto, Canada Stroke Program, St Michael s Hospital, University of Toronto, Canada Li Ka Shing Knowledge Institute of St Michael s Hospital, Toronto, Canada Electronic address
    Lancet Neurol 15:1019-27. 2016
  2. doi request reprint Visual Aid Tool to Improve Decision Making in Anticoagulation for Stroke Prevention
    Gustavo Saposnik
    Stroke Outcomes Research Unit, Division of Neurology, Department of Medicine, St Michael s Hospital, University of Toronto, Toronto, Ontario, Canada Neuroeconomics and Social Neuroscience, Department of Economics, University of Zurich, Zurich, Switzerland Li Ka Shing Knowledge Institute, St Michael s Hospital, University of Toronto, Toronto, Ontario, Canada Electronic address
    J Stroke Cerebrovasc Dis 25:2380-5. 2016
  3. doi request reprint Applying principles from the game theory to acute stroke care: Learning from the prisoner's dilemma, stag-hunt, and other strategies
    Gustavo Saposnik
    Stroke Outcomes Research Unit, Division of Neurology, Department of Medicine, St Michael s Hospital, University of Toronto, Toronto, Ontario, Canada Institute for Clinical Evaluative Sciences ICES, Toronto, Ontario, Canada Institute of Health Policy, Management and Evaluation, University of Toronto, Toronto, Ontario, Canada Neuroeconomics and Social Neuroscience, Department of Economics, University of Zurich, Switzerland
    Int J Stroke 11:274-86. 2016
  4. doi request reprint Guideline-directed low-density lipoprotein management in high-risk patients with ischemic stroke: findings from Get with the Guidelines-Stroke 2003 to 2012
    Gustavo Saposnik
    From the Division of Neurology, Department of Medicine, Stroke Outcomes Research Center, St Michael s Hospital, University of Toronto, Toronto, Ontario, Canada G S Division of Cardiology, University of California, Los Angeles G C F Duke Clinical Research Institute, Durham, NC W P, L L, A F H Stroke Service and Institute for Heart, Vascular and Stroke Care, Massachusetts General Hospital, Boston L H S and Calgary Stroke Program, Hotchkiss Brain Institute, University of Calgary, Calgary, Alberta, Canada E E S
    Stroke 45:3343-51. 2014
  5. ncbi request reprint Recent advances in stroke outcomes research: contributions from Canada
    Gustavo Saposnik
    MD, MSc, FAHA, is the director of the Stroke Outcomes Research Unit, Division of Neurology, Department of Medicine, at St Michael s adjunct scientist, Institute for Clinical Evaluative Sciences ICES and assistant professor, Department of Health Policy, Management and Evaluation, University of Toronto, Toronto, Ontario Dr Saposnik can be contacted at
    Healthc Q 13:20-3. 2010
  6. pmc JURaSSiC: accuracy of clinician vs risk score prediction of ischemic stroke outcomes
    Gustavo Saposnik
    Stroke Outcomes Research Unit, Division of Neurology, Department of Medicine, St Michael s Hospital, University of Toronto, Toronto, Canada
    Neurology 81:448-55. 2013
  7. doi request reprint The iScore predicts efficacy and risk of bleeding in the National Institute of Neurological disorders and Stroke Tissue Plasminogen Activator Stroke Trial
    Gustavo Saposnik
    Stroke Outcomes Research Unit, Division of Neurology, Department of Medicine, St Michael s Hospital, University of Toronto, Toronto, Canada
    J Stroke Cerebrovasc Dis 22:876-82. 2013
  8. doi request reprint Atrial fibrillation in ischemic stroke: predicting response to thrombolysis and clinical outcomes
    Gustavo Saposnik
    MSc, FAHA, FRCPC, Stroke Outcomes Research Center, Department of Medicine, St Michael s Hospital, University of Toronto, 55 Queen St E, Toronto, Ontario, M5C 1R6, Canada
    Stroke 44:99-104. 2013
  9. pmc Stroke Prognostication using Age and NIH Stroke Scale: SPAN-100
    Gustavo Saposnik
    Stroke Outcomes Research Unit, Division of Neurology, Department of Medicine, St Michael s Hospital, University of Toronto, Toronto, Canada
    Neurology 80:21-8. 2013
  10. doi request reprint Is pre-existing dementia an independent predictor of outcome after stroke? A propensity score-matched analysis
    Gustavo Saposnik
    Division of Neurology, Departments of Medicine and Health Policy, Management and Evaluation, Institute for Clinical Evaluative Sciences, St Michael s Hospital, University of Toronto, 55 Queen St East, Suite 931, Toronto, ON, M5C 1R6, Canada
    J Neurol 259:2366-75. 2012

Collaborators

Detail Information

Publications80

  1. pmc Efficacy and safety of non-immersive virtual reality exercising in stroke rehabilitation (EVREST): a randomised, multicentre, single-blind, controlled trial
    Gustavo Saposnik
    Division of Neurology, St Michael s Hospital, University of Toronto, Canada Stroke Program, St Michael s Hospital, University of Toronto, Canada Li Ka Shing Knowledge Institute of St Michael s Hospital, Toronto, Canada Electronic address
    Lancet Neurol 15:1019-27. 2016
    ..Our aim was to compare the safety and efficacy of virtual reality with recreational therapy on motor recovery in patients after an acute ischaemic stroke...
  2. doi request reprint Visual Aid Tool to Improve Decision Making in Anticoagulation for Stroke Prevention
    Gustavo Saposnik
    Stroke Outcomes Research Unit, Division of Neurology, Department of Medicine, St Michael s Hospital, University of Toronto, Toronto, Ontario, Canada Neuroeconomics and Social Neuroscience, Department of Economics, University of Zurich, Zurich, Switzerland Li Ka Shing Knowledge Institute, St Michael s Hospital, University of Toronto, Toronto, Ontario, Canada Electronic address
    J Stroke Cerebrovasc Dis 25:2380-5. 2016
    ..We provide a visual aid tool to guide clinicians and patients in the decision process of selecting oral anticoagulants for stroke prevention...
  3. doi request reprint Applying principles from the game theory to acute stroke care: Learning from the prisoner's dilemma, stag-hunt, and other strategies
    Gustavo Saposnik
    Stroke Outcomes Research Unit, Division of Neurology, Department of Medicine, St Michael s Hospital, University of Toronto, Toronto, Ontario, Canada Institute for Clinical Evaluative Sciences ICES, Toronto, Ontario, Canada Institute of Health Policy, Management and Evaluation, University of Toronto, Toronto, Ontario, Canada Neuroeconomics and Social Neuroscience, Department of Economics, University of Zurich, Switzerland
    Int J Stroke 11:274-86. 2016
    ..Game theory is the analysis of interactions between individuals to study how conflict and cooperation affect our decisions...
  4. doi request reprint Guideline-directed low-density lipoprotein management in high-risk patients with ischemic stroke: findings from Get with the Guidelines-Stroke 2003 to 2012
    Gustavo Saposnik
    From the Division of Neurology, Department of Medicine, Stroke Outcomes Research Center, St Michael s Hospital, University of Toronto, Toronto, Ontario, Canada G S Division of Cardiology, University of California, Los Angeles G C F Duke Clinical Research Institute, Durham, NC W P, L L, A F H Stroke Service and Institute for Heart, Vascular and Stroke Care, Massachusetts General Hospital, Boston L H S and Calgary Stroke Program, Hotchkiss Brain Institute, University of Calgary, Calgary, Alberta, Canada E E S
    Stroke 45:3343-51. 2014
    ....
  5. ncbi request reprint Recent advances in stroke outcomes research: contributions from Canada
    Gustavo Saposnik
    MD, MSc, FAHA, is the director of the Stroke Outcomes Research Unit, Division of Neurology, Department of Medicine, at St Michael s adjunct scientist, Institute for Clinical Evaluative Sciences ICES and assistant professor, Department of Health Policy, Management and Evaluation, University of Toronto, Toronto, Ontario Dr Saposnik can be contacted at
    Healthc Q 13:20-3. 2010
    ..By linking the care people get to the outcomes they experience, outcomes research can become the key to developing better ways to monitor and improve the quality of care. ..
  6. pmc JURaSSiC: accuracy of clinician vs risk score prediction of ischemic stroke outcomes
    Gustavo Saposnik
    Stroke Outcomes Research Unit, Division of Neurology, Department of Medicine, St Michael s Hospital, University of Toronto, Toronto, Canada
    Neurology 81:448-55. 2013
    ..We compared the accuracy of clinicians and a risk score (iScore) to predict observed outcomes following an acute ischemic stroke...
  7. doi request reprint The iScore predicts efficacy and risk of bleeding in the National Institute of Neurological disorders and Stroke Tissue Plasminogen Activator Stroke Trial
    Gustavo Saposnik
    Stroke Outcomes Research Unit, Division of Neurology, Department of Medicine, St Michael s Hospital, University of Toronto, Toronto, Canada
    J Stroke Cerebrovasc Dis 22:876-82. 2013
    ..Further prospective studies are needed before a change in practice can be recommended...
  8. doi request reprint Atrial fibrillation in ischemic stroke: predicting response to thrombolysis and clinical outcomes
    Gustavo Saposnik
    MSc, FAHA, FRCPC, Stroke Outcomes Research Center, Department of Medicine, St Michael s Hospital, University of Toronto, 55 Queen St E, Toronto, Ontario, M5C 1R6, Canada
    Stroke 44:99-104. 2013
    ..Atrial fibrillation (AF) increases the risk of stroke and is associated with poor stroke outcomes. Limited tools are available to evaluate clinical outcomes and response to thrombolysis in stroke patients with AF...
  9. pmc Stroke Prognostication using Age and NIH Stroke Scale: SPAN-100
    Gustavo Saposnik
    Stroke Outcomes Research Unit, Division of Neurology, Department of Medicine, St Michael s Hospital, University of Toronto, Toronto, Canada
    Neurology 80:21-8. 2013
    ..We evaluated the effect of an index combining age and stroke severity on response to IV tissue plasminogen activator (tPA) among patients in the National Institute of Neurological Disorders and Stroke (NINDS) tPA stroke trials...
  10. doi request reprint Is pre-existing dementia an independent predictor of outcome after stroke? A propensity score-matched analysis
    Gustavo Saposnik
    Division of Neurology, Departments of Medicine and Health Policy, Management and Evaluation, Institute for Clinical Evaluative Sciences, St Michael s Hospital, University of Toronto, 55 Queen St East, Suite 931, Toronto, ON, M5C 1R6, Canada
    J Neurol 259:2366-75. 2012
    ..Pre-existing dementia may not necessarily preclude access to thrombolytic therapy and specialized stroke care...
  11. doi request reprint The iScore predicts effectiveness of thrombolytic therapy for acute ischemic stroke
    Gustavo Saposnik
    Department of Medicine, St Michael s Hospital, University of Toronto, Toronto, Ontario, Canada
    Stroke 43:1315-22. 2012
    ..The purpose of this study was to determine the ability of the iScore to predict clinical response and risk of hemorrhagic transformation after tPA...
  12. doi request reprint Fabry's disease: a prospective multicenter cohort study in young adults with cryptogenic stroke
    Gustavo Saposnik
    Departments of Medicine and Health Policy, Management and Evaluation, Division of Neurology, Stroke Outcomes Research Unit, St Michael s Hospital, University of Toronto, Toronto, ON, Canada
    Int J Stroke 7:265-73. 2012
    ..Limited information is available on the prevalence of Fabry's disease, a treatable multisystem inherited lysosomal storage disorder, and disability in young patients with cryptogenic stroke...
  13. doi request reprint Care and outcomes in patients with ischemic stroke with and without preexisting dementia
    G Saposnik
    Department of Medicine, University of Toronto, Toronto M5C 1R6, Canada
    Neurology 77:1664-73. 2011
    ..To describe clinical characteristics and evaluate processes of care and outcomes at discharge in patients with ischemic stroke with and without preexisting dementia...
  14. doi request reprint Virtual reality in stroke rehabilitation: a meta-analysis and implications for clinicians
    Gustavo Saposnik
    Stroke Outcomes Research Unit, Department of Medicine, 55 Queen Street East, Suite 931, St Michael s Hospital, University of Toronto, Toronto, M5C 1R6, Canada
    Stroke 42:1380-6. 2011
    ..Virtual reality (VR) technology is a novel adjunctive therapy that could be applied in neurorehabilitation. We performed a meta-analysis to determine the added benefit of VR technology on arm motor recovery after stroke...
  15. doi request reprint Stroke unit care: does ischemic stroke subtype matter?
    Gustavo Saposnik
    Stroke Outcomes Research Unit, Stroke Research Unit, Department of Medicine, Division of Neurology, St Michael s Hospital, University of Toronto, Toronto, Ontario, Canada
    Int J Stroke 6:244-50. 2011
    ..Stroke unit care improves outcomes following ischemic stroke. However, it is not known whether all ischemic stroke subtypes benefit equally from stroke unit admission...
  16. doi request reprint The iScore predicts poor functional outcomes early after hospitalization for an acute ischemic stroke
    Gustavo Saposnik
    Stroke Outcomes Research Unit, Stroke Outcome Research Canada Working Group, Department of Medicine, St Michael s Hospital, University of Toronto, 55 Queen Street E, Toronto, Ontario, M5C 1R6, Canada
    Stroke 42:3421-8. 2011
    ..The iScore is a prediction tool originally developed to estimate the risk of death after hospitalization for an acute ischemic stroke. Our objective was to determine whether the iScore could also predict poor functional outcomes...
  17. doi request reprint Age disparities in stroke quality of care and delivery of health services
    Gustavo Saposnik
    Stroke Research Unit, Division of Neurology, Department of Medicine, St Michael s Hospital, University of Toronto, Toronto, Ontario, Canada
    Stroke 40:3328-35. 2009
    ..Limited information is available on the effect of age on stroke management and care delivery. Our aim was to determine whether access to stroke care, delivery of health services, and clinical outcomes after stroke are affected by age...
  18. doi request reprint Stroke and Heart Failure: Clinical Features, Access to Care, and Outcomes
    Jitphapa Pongmoragot
    Stroke Outcomes Research Center, Division of Neurology, Department of Medicine, St Michael s Hospital, University of Toronto, Toronto, Ontario, Canada
    J Stroke Cerebrovasc Dis 25:1048-56. 2016
    ..Limited information is known regarding acute ischemic stroke (AIS) and heart failure (HF). The aim of the study was to evaluate clinical characteristics, predisposing factors, and outcomes in AIS with HF...
  19. doi request reprint Do all age groups benefit from organized inpatient stroke care?
    Gustavo Saposnik
    Stroke Research Unit, Division of Neurology, Department of Medicine, Stroke Outcome Research Canada, St Michael s Hospital, University of Toronto, Toronto, Ontario, Canada
    Stroke 40:3321-7. 2009
    ..We sought to determine whether the reduction in mortality or institutionalization seen with organized stroke care was similar across all age groups...
  20. doi request reprint Gender differences in stroke care and outcomes in Ontario
    Moira K Kapral
    Department of Medicine, University of Toronto, Toronto General Hospital, 200 Elizabeth St, Toronto, Ontario, Canada
    Womens Health Issues 21:171-6. 2011
    ....
  21. doi request reprint IScore: a risk score to predict death early after hospitalization for an acute ischemic stroke
    Gustavo Saposnik
    Stroke Outcomes Research Centre, Stroke Outcome Research Canada Working Group, Department of Medicine, St Michael s Hospital, University of Toronto, 55 Queen St E, Toronto, Ontario, Canada
    Circulation 123:739-49. 2011
    ..Our aim was to identify predictors of mortality and to develop and validate a risk score model using information available at hospital presentation...
  22. pmc Pulmonary embolism in ischemic stroke: clinical presentation, risk factors, and outcome
    Jitphapa Pongmoragot
    Stroke Outcomes Research Center, Division of Neurology, Department of Medicine, St Michael s Hospital, University of Toronto, Ontario, Canada
    J Am Heart Assoc 2:e000372. 2013
    ..Limited information is available on the frequency of pulmonary embolism (PE) in patients with an acute ischemic stroke (AIS). We evaluated clinical characteristics, predisposing factors, and outcomes in AIS patients with PE...
  23. doi request reprint Escalating levels of access to in-hospital care and stroke mortality
    Gustavo Saposnik
    Stroke Research Unit, Division of Neurology, Department of Medicine, St Michael s Hospital, University of Toronto, Toronto, M5C 1R6, Canada
    Stroke 39:2522-30. 2008
    ..However, limited information is available comparing different levels of organized care. Our aim was to determine whether escalating levels of organized care can improve stroke outcomes...
  24. doi request reprint Variables associated with 7-day, 30-day, and 1-year fatality after ischemic stroke
    Gustavo Saposnik
    Stroke Research Unit, Division of Neurology, Department of Medicine, Li Ka Shing Knowledge Institute, St Michael s Hospital, University of Toronto, Toronto, Canada
    Stroke 39:2318-24. 2008
    ..However, limited information is available concerning variables associated with stroke case fatality at these different points in time. We sought to identify and compare variables associated with 7-day, 30-day, and 1-year stroke fatality...
  25. pmc Do all ischemic stroke subtypes benefit from organized inpatient stroke care?
    E E Smith
    Calgary Stroke Program, Department of Clinical Neurosciences, Hotchkiss Brain Institute, University of Calgary, Calgary, AB, Canada T2N 2T9
    Neurology 75:456-62. 2010
    ..We analyzed the effect of organized stroke care in all stroke subtypes in a longitudinal cohort study using data from the Registry of the Canadian Stroke Network...
  26. ncbi request reprint Predictors of major neurologic improvement after thrombolysis in acute stroke
    Gustavo Saposnik
    Department of Clinical Neurological Sciences, London Health Science Center, The University of Western Ontario, London, Ontario, Canada
    Neurology 65:1169-74. 2005
    ..Major neurologic improvement at 24 hours after administration of recombinant tissue plasminogen activator (rt-PA) in acute stroke may predict good outcome at 3 months...
  27. doi request reprint Stroke in the very elderly: hospital care, case fatality and disposition
    Gustavo Saposnik
    Stroke Research Program, South East Toronto Regional Stroke Center, Division of Neurology, Department of Medicine, St Michael s Hospital, Ont, Canada
    Cerebrovasc Dis 27:537-43. 2009
    ..However, limited information is available about the burden of stroke in individuals over 90...
  28. pmc Effectiveness of virtual reality using Wii gaming technology in stroke rehabilitation: a pilot randomized clinical trial and proof of principle
    Gustavo Saposnik
    Division of Neurology, Departments of Medicine and Health Policy Management and Evaluation and Institute for Clinical Evaluative Sciences, Li Ka Shing Knowledge Institute of St Michael s Hospital, Dalla Lana, School of Public Health, University of Toronto, Ontario, Canada
    Stroke 41:1477-84. 2010
    ..Although existing evidence suggests that increasing intensity of stroke rehabilitation therapy results in better motor recovery, limited evidence is available on the efficacy of virtual reality for stroke rehabilitation...
  29. doi request reprint Organized outpatient care: stroke prevention clinic referrals are associated with reduced mortality after transient ischemic attack and ischemic stroke
    Fiona Webster
    Department of Surgery, University of Toronto, Toronto, Ontario, M5G 1V7, Canada
    Stroke 42:3176-82. 2011
    ..We compared 1-year mortality and stroke readmission in patients with transient ischemic attack or ischemic stroke referred versus not referred to an SPC...
  30. doi request reprint Socioeconomic status, hospital volume, and stroke fatality in Canada
    Gustavo Saposnik
    Department of Medicine, Division of Neurology, Stroke Research Unit, South East Toronto Regional Stroke Center, St Michael sHospital, University of Toronto, Toronto, Canada
    Stroke 39:3360-6. 2008
    ..We sought to determine whether residence in a low-income neighborhood was associated with admission to low-volume facilities and whether this contributed to differences in fatality after stroke...
  31. doi request reprint Influence of socioeconomic status on distance traveled and care after stroke
    Christopher Ahuja
    Queen s University, St Michael s Hospital, Toronto, Canada
    Stroke 43:233-5. 2012
    ..Socioeconomic status may influence access to stroke care, including transportation and admission to different facility types...
  32. ncbi request reprint Weekends: a dangerous time for having a stroke?
    Gustavo Saposnik
    Stroke Program, Department of Clinical Neurological Sciences, London Health Sciences Center, University of Western Ontario, London, ON, Canada
    Stroke 38:1211-5. 2007
    ..However, limited information is available concerning the "weekend effect" on stroke mortality. Our aim was to evaluate the impact of weekend admissions on stroke mortality in different settings...
  33. doi request reprint Bilateral medial medullary infarction: a systematic review
    Jitphapa Pongmoragot
    Stroke Research Unit, Division of Neurology, Department of Medicine, St Michael s Hospital, University of Toronto, Toronto, Ontario, Canada
    J Stroke Cerebrovasc Dis 22:775-80. 2013
    ..Clinical presentations were mostly rostral medullary lesions. Large-artery atherosclerosis and branch disease were the most common stroke mechanisms. The clinical outcome was usually poor. ..
  34. doi request reprint Predicting clinical outcomes after thrombolysis using the iScore: results from the Virtual International Stroke Trials Archive
    Gustavo Saposnik
    From the Stroke Outcomes Research Unit, Division of Neurology, Department of Medicine, St Michael s Hospital, Institute of Health Policy, Management and Evaluation iHPME, University of Toronto, Toronto, Canada G S Departments of Epidemiology and Biostatistics, Michigan State University, East Lansing, MI M J R Clinical and Translational Science Institute, Department of Neurology, University of California, San Francisco, CA S C J Stroke Trials Unit, Division of Stroke Medicine, University of Nottingham, Nottingham, United Kingdom P M W B Department of Neurology, Medical University of South Carolina, Charleston, SC B O and Institute for Clinical Evaluative Sciences ICES, Toronto, Canada G S
    Stroke 44:2755-9. 2013
    ..Our goal was to determine the ability of the iScore to estimate clinical outcomes after intravenous thrombolysis tissue-type plasminogen activator (tPA) in the Virtual International Stroke Trials Archive (VISTA)...
  35. doi request reprint Is stroke history reliably reported by elderly with cognitive impairment? A community-based study
    Ya Ping Jin
    Department of Clinical Neurological Sciences, London Health Sciences Centre and University of Western Ontario, London, Ontario, Canada
    Neuroepidemiology 35:215-20. 2010
    ..We tested the validity of response to a stroke questionnaire versus clinical diagnosis of stroke among elderly people with and without cognitive impairment...
  36. doi request reprint The Canadian Neurological Scale and the NIHSS: development and validation of a simple conversion model
    Yongchai Nilanont
    Division of Neurology, Department of Medicine, Faculty of Medicine, Siriraj Hospital, Mahidol University, Bangkok, Thailand
    Cerebrovasc Dis 30:120-6. 2010
    ..The CNS requires less extensive neurological evaluation and is quicker and simpler to administer...
  37. doi request reprint Intracerebral hemorrhage from cerebral venous thrombosis
    Jitphapa Pongmoragot
    Stroke Outcomes Research Unit, Division of Neurology, Department of Medicine, St Michael s Hospital, University of Toronto, Canada
    Curr Atheroscler Rep 14:382-9. 2012
    ..Intracerebral hemorrhage in the context of CVT is usually associated with poorer outcomes compared to CVT without ICH...
  38. pmc Predicting clinical outcomes and response to thrombolysis in acute stroke patients with diabetes
    Davar Nikneshan
    Stroke Outcomes Research Centre, Division of Neurology, Department of Medicine, St Michael s Hospital, University of Toronto, Toronto, Canada
    Diabetes Care 36:2041-7. 2013
    ..We explored how the iScore (www.sorcan.ca/iscore), a validated risk score, predicts clinical outcomes in stroke patients with and without diabetes...
  39. doi request reprint Stroke outcome in those over 80: a multicenter cohort study across Canada
    Gustavo Saposnik
    South East Toronto Regional Stroke Center, Division of Neurology, Department of Medicine, St Michael s Hospital, University of Toronto, Toronto, Ontario, Canada
    Stroke 39:2310-7. 2008
    ..However, limited information is available about the burden of stroke in individuals over 80. We sought to evaluate differences in clinical outcomes in Canadians over 80 years old hospitalized for an acute ischemic stroke...
  40. doi request reprint Cardiac Arrest in Acute Ischemic Stroke: Incidence, Predisposing Factors, and Clinical Outcomes
    Raed A Joundi
    Stroke Outcomes Research Unit, Division of Neurology, Department of Medicine, St Michael s Hospital, University of Toronto, Toronto, Ontario, Canada Institute of Health Policy, Management and Evaluation, University of Toronto, Toronto, Ontario, Canada
    J Stroke Cerebrovasc Dis 25:1644-52. 2016
    ..We studied a large ischemic stroke inpatient population and compared patients with and without cardiac arrest...
  41. doi request reprint iPad technology for home rehabilitation after stroke (iHOME): a proof-of-concept randomized trial
    Gustavo Saposnik
    Stroke Outcomes Research Centre, Division of Neurology, St Michael s Hospital, University of Toronto, Toronto, Canada Neuroscience Research Program, Li Ka Shing Knowledge Institute, St Michael s Hospital, University of Toronto, Toronto, Canada
    Int J Stroke 9:956-62. 2014
    ..Fine motor movements are captured on the tablet computer through electrical fields and can be qualitatively and quantitatively assessed. Evidence is limited on tablet use for stroke rehabilitation...
  42. doi request reprint Applying the evidence: do patients with stroke, coronary artery disease, or both achieve similar treatment goals?
    Gustavo Saposnik
    Division of Cardiology, Canadian Heart Research Centre and Terrence Donnelly Heart Centre, University of Toronto, Canada
    Stroke 40:1417-24. 2009
    ..We sought to evaluate and compare differences in treatment patterns and the attainment of current guideline-recommended targets in unselected high-risk ambulatory patients with CAD, CVD, or both...
  43. doi request reprint Disparities in management patterns and outcomes of patients with non-ST-elevation acute coronary syndrome with and without a history of cerebrovascular disease
    Tony C Lee
    Division of Cardiology, St Michael s Hospital, University of Toronto, Toronto, Ontario, Canada
    Am J Cardiol 105:1083-9. 2010
    ....
  44. doi request reprint The Ischemic Stroke Predictive Risk Score Predicts Early Neurological Deterioration
    Young Dae Kim
    Department of Neurology, Yonsei University College of Medicine, Seoul, Republic of Korea Stroke Outcomes Research Unit, Division of Neurology, Department of Medicine, St Michael s Hospital, University of Toronto, Toronto, Ontario, Canada
    J Stroke Cerebrovasc Dis 25:819-24. 2016
    ..The aim of this study was to investigate whether there are differences in the occurrence of END according to the ischemic stroke predictive risk score (iScore), which was developed to predict short- and long-term mortality...
  45. doi request reprint Very short paroxysms account for more than half of the cases of atrial fibrillation detected after stroke and TIA: a systematic review and meta-analysis
    Luciano A Sposato
    Department of Clinical Neurological Sciences, London Health Sciences Centre Western University, London, ON, Canada
    Int J Stroke 10:801-7. 2015
    ..Guidelines suggest that only poststroke atrial fibrillation episodes lasting 30 s or longer should be considered for anticoagulation. However, little evidence supports this recommendation...
  46. doi request reprint Influence of seizures on stroke outcomes: a large multicenter study
    Chin Wei Huang
    From the Epilepsy Program, Department of Clinical Neurological Sciences C W H, D A S, J G B, Western University, London, Canada Department of Neurology C W H, National Cheng Kung University Hospital, School of Medicine, National Cheng Kung University, Tainan, Taiwan University of Toronto G S, St Michael s Hospital and Institute for Clinical Evaluative Sciences G S, J F, Toronto, Canada
    Neurology 82:768-76. 2014
    ....
  47. ncbi request reprint Does a birthday predispose to vascular events?
    Gustavo Saposnik
    Stroke Team, Department of Clinical Neurological Sciences, London Health Sciences Center, University of Western Ontario, Ontario, Canada
    Neurology 67:300-4. 2006
    ..To examine the influence of birthdays on the onset and course of vascular events such as stroke, TIA, and acute myocardial infarction (AMI)...
  48. doi request reprint Detection and treatment of post stroke depression: results from the registry of the Canadian stroke network
    Nathan Herrmann
    Department of Psychiatry, Sunnybrook Health Sciences Centre, Toronto, Ontario, Canada
    Int J Geriatr Psychiatry 26:1195-200. 2011
    ..Depression occurs in approximately one-third of patients following stroke based on studies that screen entire stroke populations. Less is known about the detection and treatment of post stroke depression (PSD) in routine clinical practice...
  49. doi request reprint Association between weekend hospital presentation and stroke fatality
    Jiming Fang
    Toronto General Hospital, 200 Elizabeth Street, Toronto, Ontario, Canada
    Neurology 75:1589-96. 2010
    ..Previous studies have found higher stroke case fatality in patients admitted to the hospital on weekends compared to weekdays, but the reasons for this association are not known...
  50. doi request reprint Ischemic Stroke Risk in Patients With Atrial Fibrillation and CHA2DS2-VASc Score of 1: Systematic Review and Meta-Analysis
    Raed A Joundi
    From the Division of Neurology, Department of Medicine, University of Toronto, Toronto, ON, Canada R A J Ivey Business School, Western University, London, ON, Canada L E C Department of Epidemiology and Biostatistics, Schulich School of Medicine and Dentistry, Western University, London, ON, Canada L E C Department of Clinical Neurological Sciences, London Health Sciences Centre Western University, London, ON, Canada L A S and Stroke Outcomes Research Unit, Division of Neurology, Department of Medicine, St Michael s Hospital, University of Toronto, and Institute of Health Policy, Management and Evaluation, University of Toronto, Toronto, Ontario, Canada G S
    Stroke 47:1364-7. 2016
    ..We conducted a systematic review and meta-analysis of the risk of ischemic stroke for patients with atrial fibrillation and CHA2DS2-VASc score of 0, 1, or 2 not treated with oral anticoagulation...
  51. doi request reprint Post-stroke depression, obstructive sleep apnea, and cognitive impairment: Rationale for, and barriers to, routine screening
    Richard H Swartz
    University of Toronto, Toronto, Canada Department of Medicine Neurology, Sunnybrook Health Sciences Centre, Toronto, Canada Hurvitz Brain Sciences Research Program, Toronto, Canada Heart and Stroke Foundation Canadian Partnership for Stroke Recovery, Toronto, Canada University of Toronto Stroke Program, Toronto, Canada
    Int J Stroke 11:509-18. 2016
    ..These tools may in turn facilitate large-scale randomized controlled treatment trials of interventions for DOC conditions that may help to improve cardiovascular outcomes after stroke or TIA. ..
  52. doi request reprint Underutilization of Ambulatory ECG Monitoring After Stroke and Transient Ischemic Attack: Missed Opportunities for Atrial Fibrillation Detection
    Jodi D Edwards
    From the Sunnybrook Research Institute and Hurvitz Brain Sciences Program J D E, D J G, L C Campbell Cognitive Neurology Research Unit and the Heart and Stroke Foundation Canadian Partnership for Stroke Recovery, Sunnybrook Site J D E and Division of Neurology, Department of Medicine, Sunnybrook Health Sciences Centre D J G, Ontario, Canada Division of Neurology G S, D J G and Division of Internal Medicine M K K, Department of Medicine, University of Toronto, Ontario, Canada Division of General Internal Medicine and Toronto General Research Institute, University Health Network, Ontario, Canada M K K and Institute for Clinical Evaluative Sciences, Toronto, Ontario, Canada M K K, J F, G S, D J G
    Stroke 47:1982-9. 2016
    ..Detection and treatment of atrial fibrillation is a major goal in secondary stroke prevention. Guidelines recommend at least 24 hours of ECG monitoring after stroke. However, it is unclear how often this is done in routine practice...
  53. doi request reprint Added Benefit of Stent Retriever Technology for Acute Ischemic Stroke: A Pooled Analysis of the NINDS tPA, SWIFT, and STAR Trials
    Gustavo Saposnik
    Stroke Outcomes Research Center, Division of Neurology, Department of Medicine, St Michael s Hospital, University of Toronto, Toronto, Ontario, Canada Institute of Health Policy, Management and Evaluation, University of Toronto, Toronto, Ontario, Canada Applied Health Research Center, Li Ka Shing Knowledge Institute, St Michael s Hospital, Toronto, Ontario, Canada Calgary Stroke Program, Department of Clinical Neurosciences and Radiology, University of Calgary, Alberta, Canada Professor of Neurosurgery and Radiology, University at Buffalo, State University of New York, Buffalo, New York Department of Neuroscience, Medical University of South Carolina, Charleston, South Carolina Dell Medical School, University of Texas, Austin, Texas
    Neurosurgery 77:454-61. 2015
    ..Endovascular treatment is increasingly being used in acute stroke care. However, although stent retrievers show improved flow restoration rates, their clinical benefits have been uncertain...
  54. doi request reprint Is it safe to drive after acute mild stroke? A preliminary report
    Megan A Hird
    Neuroscience Research Program, Keenan Research Centre for Biomedical Science of the Li Ka Shing Knowledge Institute, St Michael s Hospital, Toronto, Ontario, Canada University of Toronto, Toronto, Ontario, Canada
    J Neurol Sci 354:46-50. 2015
    ..The aim of this study was to investigate the driving performance of patients with acute mild stroke...
  55. doi request reprint The CLOQS trial protocol: a cluster-randomized trial evaluating a simple, low-cost intervention to reduce treatment times in acute stroke
    Richard H Swartz
    Department of Medicine Neurology, Sunnybrook Health Sciences Centre, University of Toronto, Toronto, ON, Canada
    Int J Stroke 9:525-8. 2014
    ..Paradoxically, the earlier a stroke patient arrives to hospital, the longer treatment takes. There is an urgent need to shift focus away from the 4.5 hour time window, towards treatment times <60 minutes...
  56. doi request reprint Prevalence of Fabry disease in stroke patients--a systematic review and meta-analysis
    Qiyun Shi
    Health and Rehabilitation Sciences, Western University, Elborn College, London, Ontario Stroke Outcomes Research Center, Department of Medicine, St Michael s Hospital, University of Toronto, Toronto Electronic address
    J Stroke Cerebrovasc Dis 23:985-92. 2014
    ..Fabry disease is an uncommon but treatable cause of stroke. Enzyme replacement therapy helps improve neurologic symptoms. We conducted a systematic review and meta-analysis to evaluate the prevalence of Fabry disease in stroke patients...
  57. doi request reprint Treatment and outcomes of non-ST elevation acute coronary syndromes in relation to burden of pre-existing vascular disease
    Michael Mohareb
    Terrence Donnelly Heart Centre, St Michael s Hospital, Toronto, ON, Canada University of Toronto, Toronto, ON, Canada
    Int J Cardiol 168:2720-5. 2013
    ..However, the relationships between pre-existing vascular disease and the treatment and outcome of acute coronary syndrome (ACS), have not been well characterized...
  58. doi request reprint Prevalence of Fabry disease in young patients with cryptogenic ischemic stroke
    Véronique Dubuc
    Division of Neurology, Department of Medicine, Centre Hospitalier de l Universite de Montreal, Universite de Montreal, Montreal, Quebec, Canada
    J Stroke Cerebrovasc Dis 22:1288-92. 2013
    ..A lower prevalence was found in other geographic regions...
  59. ncbi request reprint Optimizing discharge planning: clinical predictors of longer stay after recombinant tissue plasminogen activator for acute stroke
    Gustavo Saposnik
    Stroke Program, Department of Clinical Neurological Sciences and Southwestern Ontario Coordinated Stroke Strategy, London Health Science Center, The University of Western Ontario, London, Ontario, Canada
    Stroke 36:147-50. 2005
    ..Although studies have identified variables associated with LOS, few have analyzed predictors of longer stay after receiving thrombolytic therapy for acute stroke...
  60. doi request reprint Pontine warning syndrome
    Gustavo Saposnik
    Stroke Research Unit, Division of Neurology, Department of Medicine, St Michael s Hospital, University of Toronto, 55 Queen St E, Ste 931, Toronto ONM5C1R6, Canada
    Arch Neurol 65:1375-7. 2008
    ..Little is known about stroke mechanisms in patients with fluctuating symptoms and the role of branch atherosclerotic disease...
  61. doi request reprint The Use of Social Media Communications in Brain Aneurysms and Subarachnoid Hemorrhage: A Mixed-Method Analysis
    Naif M Alotaibi
    Division of Neurosurgery, Department of Surgery, University of Toronto, Toronto, Ontario, Canada Institute of Medical Science, Faculty of Medicine, University of Toronto, Toronto, Ontario, Canada
    World Neurosurg . 2016
    ..As a result, patients and caregivers may resort to social media platforms for support and education. The aim of this report is to evaluate the current use of social media and the online communications regarding brain aneurysms...
  62. pmc Decision making under uncertainty, therapeutic inertia, and physicians' risk preferences in the management of multiple sclerosis (DIScUTIR MS)
    Gustavo Saposnik
    Division of Neurology, Department of Medicine, St Michael s Hospital, University of Toronto, 55 Queen St E, Toronto, ON, M5C 1R6, Canada
    BMC Neurol 16:58. 2016
    ....
  63. doi request reprint Visual aid tool to improve decision making in acute stroke care
    Gustavo Saposnik
    1 Stroke Outcomes Research Unit, www sorcan ca Division of Neurology, Department of Medicine, St Michael s Hospital, University of Toronto, Canada
    Int J Stroke 11:868-873. 2016
    ....
  64. pmc Impact of Clinical Trial Results on the Temporal Trends of Carotid Endarterectomy and Stenting From 2002 to 2014
    Mohamad A Hussain
    From the Divisions of Vascular Surgery M A H, Z K, B A, M A O, Neurology G S, and Cardiac Surgery S V and Li Ka Shing Knowledge Institute, St Michael s Hospital M M, G S, S V, M A O, Toronto, Canada Departments of Surgery M A H, S V, M A O and Medicine J V T, G S, University of Toronto, Toronto, Canada Institute of Health Policy, Management, and Evaluation M M, J V T, G S and Leslie Dan Faculty of Pharmacy M M, University of Toronto, Canada King Saud University Li Ka Shing Collaborative Research Program M M, B A, S V, M A O Department of Surgery, Taibah University, Madinah, Kingdom of Saudi Arabia Z K Department of Surgery, King Saud University, Riyadh, Kingdom of Saudi Arabia B A, M A O Institute for Clinical Evaluative Sciences M M, J V T, Japan
    Stroke 47:2923-2930. 2016
    ..The purpose of this study was to examine the impact of conflicting clinical trial publications on the utilization rates of carotid revascularization procedures...
  65. doi request reprint Critical care management of cerebral venous thrombosis
    David Fam
    aDepartment of Neurology, University of Toronto School of Medicine bStroke Outcomes Research Unit, Li Ka Shing Knowledge Institute cInstitute of Health Policy, Management and Evaluation, University of Toronto, Toronto, Ontario, Canada Website http www sorcan ca
    Curr Opin Crit Care 22:113-9. 2016
    ..This review aims to summarize the existing evidence regarding the management of CVT, including anticoagulation and endovascular therapy...
  66. doi request reprint The iScore predicts total healthcare costs early after hospitalization for an acute ischemic stroke
    Emmanuel M Ewara
    The Centre for Excellence in Economic Analysis Research, Li Ka Shing Knowledge Institute, St Michael s Hospital, Toronto, ON, Canada
    Int J Stroke 10:1179-86. 2015
    ..The ischemic Stroke risk score is a validated prognostic score which can be used by clinicians to estimate patient outcomes after the occurrence of an acute ischemic stroke...
  67. doi request reprint A prescription at discharge improves long-term adherence for secondary stroke prevention
    Jenny P Tsai
    Division of Neurology, Department of Medicine, University of Toronto, Toronto, Ontario, Canada
    J Stroke Cerebrovasc Dis 23:2308-15. 2014
    ..Medication adherence is important for optimal secondary stroke prevention. We evaluated short-term adherence to antihypertensive and lipid-lowering agents after a new ischemic stroke, as predictor of adherence at 1 and 2 years...
  68. doi request reprint Homocysteine-lowering therapy and stroke risk, severity, and disability: additional findings from the HOPE 2 trial
    Gustavo Saposnik
    Department of Medicine, Division of Neurology, St Michael s Hospital, University of Toronto, Toronto, Ontario, Canada
    Stroke 40:1365-72. 2009
    ..Our aim was to determine whether vitamin therapy reduces the risk of ischemic and hemorrhagic stroke, as well as stroke-related disability...
  69. doi request reprint Quality of acute ischemic stroke care in Thailand: a prospective multicenter countrywide cohort study
    Yongchai Nilanont
    Division of Neurology, Department of Medicine, Faculty of Medicine Siriraj Hospital, Mahidol University, Bangkok, Thailand Electronic address
    J Stroke Cerebrovasc Dis 23:213-9. 2014
    ..Data concerning quality of acute stroke care and outcome are scarce in developing countries...
  70. doi request reprint Effect of socioeconomic status on inpatient mortality and use of postacute care after subarachnoid hemorrhage
    Blessing N R Jaja
    From the Keenan Research Centre, Li Ka Shing Knowledge Institute B N R J, G S, R N, T A S, K E T, R L M, Division of Neurology G S, Division of Neurosurgery B N R J, T A S, R L M, St Michael s Hospital, Toronto, ON, Canada Institute of Medical Science B N R J, G S, T A S, R L M, Dalla Lana School of Public Health R N, K E T, University of Toronto, Toronto, ON, Canada and Division of Neurosurgery D R, McMaster University, Hamilton, ON, Canada
    Stroke 44:2842-7. 2013
    ..This study investigated socioeconomic status-related differences in risk of inpatient mortality and use of institutional postacute care after subarachnoid hemorrhage in the United States and Canada...
  71. doi request reprint Roadway crash risks in recent immigrants
    Donald A Redelmeier
    Department of Medicine, University of Toronto, Canada
    Accid Anal Prev 43:2128-33. 2011
    ..These findings suggest that, contrary to popular opinion, recent immigrants are less prone to be drivers in serious motor vehicle crashes...
  72. doi request reprint Genetic testing in combination with preventive donepezil treatment for patients with amnestic mild cognitive impairment: an exploratory economic evaluation of personalized medicine
    Sandjar Djalalov
    Keenan Research Centre, Li Ka Shing Knowledge Institute, St Michael s Hospital, 30 Bond Street, Toronto, ON, M5B 1W8, Canada
    Mol Diagn Ther 16:389-99. 2012
    ....
  73. doi request reprint Delirium in acute stroke: a systematic review and meta-analysis
    Qiyun Shi
    Health and Rehabilitation Sciences, The University of Western Ontario, Elborn College, London, Ontario, Canada
    Stroke 43:645-9. 2012
    ..Delirium is common in the early stage after hospitalization for an acute stroke. We conducted a systematic review and meta-analysis to evaluate the outcomes of acute stroke patients with delirium...
  74. doi request reprint Antiepileptic drug use for treatment of epilepsy and dyslipidemia: Systematic review
    Manav V Vyas
    Division of Neurology, Department of Medicine, University of Toronto, Toronto, Ontario, Canada
    Epilepsy Res 113:44-67. 2015
    ..To characterize the association between commonly used anti-epileptic drugs (AEDs) and plasma lipid levels in patients with epilepsy...
  75. doi request reprint Stroke preparedness in children: translating knowledge into behavioral intent: a systematic review and meta-analysis
    Cassandra Ottawa
    Sunnybrook Health Sciences Centre, Toronto, ON, Canada
    Int J Stroke 10:1008-13. 2015
    ..We performed a systematic review and meta-analysis to investigate whether educational interventions targeting children improve stroke knowledge and lead to behavioral changes...
  76. pmc Disparities in surgery among patients with intractable epilepsy in a universal health system
    Jorge G Burneo
    From the Epilepsy Program J G B, London Health Sciences Centre and Western University the Institute for Clinical Evaluative Sciences ICES S Z S, K L, S L, G S, A X G, Toronto the Division of Neurology G S, St Michael s Hospital, Toronto, Canada the Department of Neuroeconomics G S, University of Zurich, Switzerland and the Schulich School of Medicine and Dentistry A X G, Western University, London, Canada
    Neurology 86:72-8. 2016
    ..To assess the use of epilepsy surgery in patients with medically intractable epilepsy in a publicly funded universal health care system...
  77. doi request reprint Does the Volume of Ischemic Stroke Admissions Relate to Clinical Outcomes in the Ontario Stroke System?
    Ruth E Hall
    From the Institute for Clinical Evaluative Sciences R E H, J F, G S, M T B Ontario Stroke Network R E H, M T B College of Physicians and Surgeons of Ontario K H Department of Medicine, University of Toronto G S, M T B St Michael s Hospital G S and Toronto Rehabilitation Institute, University Hospital Network M T B Toronto, Ontario, Canada
    Circ Cardiovasc Qual Outcomes 8:S141-7. 2015
    ..Better outcomes have been found among hospitals treating higher volumes of patients for specific surgical and medical conditions. We examined hospital ischemic stroke (IS) volume and 30-day mortality to inform regionalization planning...
  78. doi request reprint Differential effect of B-vitamin therapy by antiplatelet use on risk of recurrent vascular events after stroke
    Baback Arshi
    From the Department of Neurology, University of Southern California, Los Angeles B A, A T Department of Neurology, Rancho Los Amigos National Rehabilitation Center, Downey, CA B A, A T Department of Neurosciences, Medical University of South Carolina, Charleston B O Department of Biomathematics, University of California, Los Angeles D M and Department of Neurology, University of Toronto, Toronto, Ontario, Canada G S
    Stroke 46:870-3. 2015
    ..One post hoc analysis revealed an interaction between B vitamin therapy and antiplatelet use; however, those results have not been replicated in other studies or populations...
  79. doi request reprint Cognitive, on-road, and simulator-based driving assessment after stroke
    Megan A Hird
    Neuroscience Research, St Michael s Hospital, Toronto, Ontario, Canada University of Toronto, Canada
    J Stroke Cerebrovasc Dis 23:2654-70. 2014
    ..Future studies should assess poststroke driving fitness by differentiating different stages, severities, and locations of stroke...
  80. doi request reprint Pearls and oy-sters: carotid dissection with normal arterial lumen
    Jitphapa Pongmoragot
    Stroke Program, Division of Neurology, Department of Medicine, St Michael s Hospital, University of Toronto, Ontario, Canada
    Neurology 80:e115-7. 2013
    ..Isolated lower cranial nerve palsy in carotid dissection is uncommon...