Jean Francois Leonard

Summary

Affiliation: Sanofi-Aventis Deutschland GmbH

Publications

  1. ncbi request reprint Proteomic characterization of the effects of clofibrate on protein expression in rat liver
    Jean Francois Leonard
    Drug Safety Evaluation, Sanofi Aventis, Vitry sur Seine, France
    Proteomics 6:1915-33. 2006
  2. doi request reprint Optimization of SELDI for biomarker detection in plasma
    Jean Francois Leonard
    Disposition, Safety and Animal Research, sanofi aventis R and D, Vitry sur Seine, France
    Methods Mol Biol 691:351-68. 2011
  3. pmc Identification of microRNAs in Macaca fascicularis (Cynomolgus Monkey) by Homology Search and Experimental Validation by Small RNA-Seq and RT-qPCR Using Kidney Cortex Tissues
    Yaligara Veeranagouda
    Sanofi R and D, Disposition Safety and Animal Research, Vitry sur Seine, France
    PLoS ONE 10:e0142708. 2015
  4. ncbi request reprint Early drug safety evaluation: biomarkers, signatures, and fingerprints
    Ruth Roberts
    Aventis Pharma, Drug Safety Evaluation, Centre de Recherche de Paris, Paris, France
    Drug Metab Rev 35:269-75. 2003

Collaborators

  • Eric Boitier
  • Kelvin Cain
  • Yaligara Veeranagouda
  • Jean Charles Gautier
  • Ruth Roberts
  • Catherine Prades
  • Bo Li
  • Marie Laure Ozoux
  • Jufeng Wang
  • Claire Mariet
  • Pierrick Rival
  • Xiaobing Zhou
  • Caroline Freathy
  • Beth Coyle

Detail Information

Publications4

  1. ncbi request reprint Proteomic characterization of the effects of clofibrate on protein expression in rat liver
    Jean Francois Leonard
    Drug Safety Evaluation, Sanofi Aventis, Vitry sur Seine, France
    Proteomics 6:1915-33. 2006
    ..Differential effects on those variants could result from specific PTM and could be a specific molecular signature of the clofibrate-induced protein expression modulation in rat liver...
  2. doi request reprint Optimization of SELDI for biomarker detection in plasma
    Jean Francois Leonard
    Disposition, Safety and Animal Research, sanofi aventis R and D, Vitry sur Seine, France
    Methods Mol Biol 691:351-68. 2011
    ..Last, a systematic evaluation of technical bias such as the spot and chip position and the bioprocessor sequence number may be achieved using the appropriate multivariate statistical analyses...
  3. pmc Identification of microRNAs in Macaca fascicularis (Cynomolgus Monkey) by Homology Search and Experimental Validation by Small RNA-Seq and RT-qPCR Using Kidney Cortex Tissues
    Yaligara Veeranagouda
    Sanofi R and D, Disposition Safety and Animal Research, Vitry sur Seine, France
    PLoS ONE 10:e0142708. 2015
    ..Data presented in this study may serve as a valuable resource to assess the renal safety biomarker potential of miRNAs in Cynomolgus monkeys. ..
  4. ncbi request reprint Early drug safety evaluation: biomarkers, signatures, and fingerprints
    Ruth Roberts
    Aventis Pharma, Drug Safety Evaluation, Centre de Recherche de Paris, Paris, France
    Drug Metab Rev 35:269-75. 2003
    ..the efficacious dose can provide clues on MOA for the toxicity and may allow differentiation of the pathways of the toxic response from those required for pharmacological activity...