Ekram M Saleh

Summary

Publications

  1. pmc Antagonism between curcumin and the topoisomerase II inhibitor etoposide: a study of DNA damage, cell cycle regulation and death pathways
    Ekram M Saleh
    Clinical Biochemistry and Molecular Biology unit, Cancer Biology Department, National Cancer Institute, Cairo University, Cairo, Egypt
    Cancer Biol Ther 13:1058-71. 2012
  2. doi request reprint Induction and repair of DNA double-strand breaks using constant-field gel electrophoresis and apoptosis as predictive markers for sensitivity of cancer cells to cisplatin
    Ekram M Saleh
    Clinical Biochemistry and Molecular Biology unit, Cancer Biology Department, National Cancer Institute, Cairo University, Cairo, Egypt
    Biomed Pharmacother 66:554-62. 2012
  3. doi request reprint Altered expression of proliferation-inducing and proliferation-inhibiting genes might contribute to acquired doxorubicin resistance in breast cancer cells
    Ekram M Saleh
    Biochemistry Unit, Tumour Biology Department, National Cancer Institute, Cairo University, Cairo, Egypt
    Cell Biochem Biophys 55:95-105. 2009
  4. doi request reprint Expression of RAD51, BRCA1 and P53 does not correlate with cellular radiosensitivity of normal human fibroblasts
    E M Y Saleh
    Biochemistry and Molecular Biology Unit, Cancer Biology Department, National Cancer Institute, Cairo University, Cairo, Egypt
    Ir J Med Sci 180:715-20. 2011
  5. doi request reprint Interaction of celecoxib with different anti-cancer drugs is antagonistic in breast but not in other cancer cells
    Raafat A El-Awady
    Pharmacology Unit, Department of Cancer Biology, National, Cancer Institute, Cairo University, Fom El Khalig, Cairo, Egypt
    Toxicol Appl Pharmacol 255:271-86. 2011
  6. doi request reprint Targeting DNA double-strand break repair: is it the right way for sensitizing cells to 5-fluorouracil?
    Raafat A El-Awady
    Pharmacology Unit bBiochemistry and Molecular Biology Unit, Tumour Biology Department, National Cancer Institute, Cairo University, Cairo, Egypt
    Anticancer Drugs 21:277-87. 2010
  7. ncbi request reprint Apoptosis is the most efficient death-pathway in tumor cells after topoisomerase II inhibition
    Raafat A El-Awady
    Department of Tumor Biology, National Cancer Institute, Cairo University, Cairo, Egypt
    Saudi Med J 29:558-64. 2008

Collaborators

  • Wael M Abdel-Rahman
  • Raafat A El-Awady
  • Abeer M Elsayed
  • Marwa Ezz
  • Jochen Dahm-Daphi
  • Fayek M Ghaleb
  • Mahmoud M Ali

Detail Information

Publications7

  1. pmc Antagonism between curcumin and the topoisomerase II inhibitor etoposide: a study of DNA damage, cell cycle regulation and death pathways
    Ekram M Saleh
    Clinical Biochemistry and Molecular Biology unit, Cancer Biology Department, National Cancer Institute, Cairo University, Cairo, Egypt
    Cancer Biol Ther 13:1058-71. 2012
    ..CUR alone induced autophagy, apoptosis and necrosis, whereas ETP alone or in combination with CUR led to apoptosis and necrosis...
  2. doi request reprint Induction and repair of DNA double-strand breaks using constant-field gel electrophoresis and apoptosis as predictive markers for sensitivity of cancer cells to cisplatin
    Ekram M Saleh
    Clinical Biochemistry and Molecular Biology unit, Cancer Biology Department, National Cancer Institute, Cairo University, Cairo, Egypt
    Biomed Pharmacother 66:554-62. 2012
    ....
  3. doi request reprint Altered expression of proliferation-inducing and proliferation-inhibiting genes might contribute to acquired doxorubicin resistance in breast cancer cells
    Ekram M Saleh
    Biochemistry Unit, Tumour Biology Department, National Cancer Institute, Cairo University, Cairo, Egypt
    Cell Biochem Biophys 55:95-105. 2009
    ....
  4. doi request reprint Expression of RAD51, BRCA1 and P53 does not correlate with cellular radiosensitivity of normal human fibroblasts
    E M Y Saleh
    Biochemistry and Molecular Biology Unit, Cancer Biology Department, National Cancer Institute, Cairo University, Cairo, Egypt
    Ir J Med Sci 180:715-20. 2011
    ..To evaluate the potential role of key DNA repair proteins in the sensitivity of normal human fibroblasts to ionising radiations...
  5. doi request reprint Interaction of celecoxib with different anti-cancer drugs is antagonistic in breast but not in other cancer cells
    Raafat A El-Awady
    Pharmacology Unit, Department of Cancer Biology, National, Cancer Institute, Cairo University, Fom El Khalig, Cairo, Egypt
    Toxicol Appl Pharmacol 255:271-86. 2011
    ..Moreover, combination of celecoxib with other drugs should be tailored to the tumor type, drug and administration schedule...
  6. doi request reprint Targeting DNA double-strand break repair: is it the right way for sensitizing cells to 5-fluorouracil?
    Raafat A El-Awady
    Pharmacology Unit bBiochemistry and Molecular Biology Unit, Tumour Biology Department, National Cancer Institute, Cairo University, Cairo, Egypt
    Anticancer Drugs 21:277-87. 2010
    ..This result shows that targeting DSB repair is not always associated with increased sensitivity to DNA damaging agents such as 5-FU because it may affect other cellular responses such as cell cycle regulation and induction of apoptosis...
  7. ncbi request reprint Apoptosis is the most efficient death-pathway in tumor cells after topoisomerase II inhibition
    Raafat A El-Awady
    Department of Tumor Biology, National Cancer Institute, Cairo University, Cairo, Egypt
    Saudi Med J 29:558-64. 2008
    ..To compare the efficiency of apoptosis and other modes of cell death in killing tumor cells after the induction of DNA damage by topoisomerase inhibitors like etoposide...