Hirotoshi Sakaguchi

Summary

Publications

  1. doi request reprint Danaparoid as the prophylaxis for hepatic veno-occlusive disease after allogeneic hematopoietic stem cell transplantation in childhood hematological malignancy
    Hirotoshi Sakaguchi
    Division of Haematology and Oncology, Children s Medical Center, Japanese Red Cross Nagoya First Hospital, Nagoya, Japan
    Pediatr Blood Cancer 55:1118-25. 2010
  2. doi request reprint Correlation of CYP2C19 phenotype with voriconazole plasma concentration in children
    Atsushi Narita
    Department of Pediatrics, Nagoya University Graduate School of Medicine, Nagoya, Japan
    J Pediatr Hematol Oncol 35:e219-23. 2013
  3. doi request reprint Incidence, clinical features, and risk factors of idiopathic pneumonia syndrome following hematopoietic stem cell transplantation in children
    Hirotoshi Sakaguchi
    Department of Pediatrics, Nagoya University Graduate School of Medicine, Nagoya, Japan
    Pediatr Blood Cancer 58:780-4. 2012
  4. pmc Aberrant DNA Methylation Is Associated with a Poor Outcome in Juvenile Myelomonocytic Leukemia
    Hirotoshi Sakaguchi
    Department of Pediatrics, Nagoya University Graduate School of Medicine, Nagoya, Japan
    PLoS ONE 10:e0145394. 2015
  5. doi request reprint Aberrant phosphorylation of STAT5 by granulocyte-macrophage colony-stimulating factor in infant cytomegalovirus infection mimicking juvenile myelomonocytic leukemia
    Nobuhiro Nishio
    Department of Pediatrics, Nagoya University Graduate School of Medicine, Shouwa ku, Nagoya, Japan
    Leuk Res 35:1261-4. 2011
  6. pmc Paroxysmal nocturnal hemoglobinuria and telomere length predicts response to immunosuppressive therapy in pediatric aplastic anemia
    Atsushi Narita
    Department of Pediatrics, Nagoya University Graduate School of Medicine, Nagoya, Japan
    Haematologica 100:1546-52. 2015
  7. doi request reprint De novo childhood myelodysplastic/myeloproliferative disease with unique molecular characteristics
    Olfat Ismael
    Department of Paediatrics, Nagoya University Graduate School of Medicine, Nagoya, Aichi, Japan
    Br J Haematol 158:129-37. 2012
  8. doi request reprint Reduced intensity conditioning in allogeneic stem cell transplantation for AML with Down syndrome
    Hideki Muramatsu
    Department of Pediatrics, Nagoya University Graduate School of Medicine, Nagoya, Japan
    Pediatr Blood Cancer 61:925-7. 2014
  9. doi request reprint Somatic mosaicism for oncogenic NRAS mutations in juvenile myelomonocytic leukemia
    Sayoko Doisaki
    Department of Pediatrics, Nagoya University Graduate School of Medicine, Nagoya, Japan
    Blood 120:1485-8. 2012
  10. doi request reprint Molecular lesions in childhood and adult acute megakaryoblastic leukaemia
    Asahito Hama
    Department of Paediatrics, Nagoya University Graduate School of Medicine, Nagoya, Japan
    Br J Haematol 156:316-25. 2012

Collaborators

Detail Information

Publications13

  1. doi request reprint Danaparoid as the prophylaxis for hepatic veno-occlusive disease after allogeneic hematopoietic stem cell transplantation in childhood hematological malignancy
    Hirotoshi Sakaguchi
    Division of Haematology and Oncology, Children s Medical Center, Japanese Red Cross Nagoya First Hospital, Nagoya, Japan
    Pediatr Blood Cancer 55:1118-25. 2010
    ..Therapeutic modalities for established VOD are limited, and severe VOD characterized by multiple organ failure is associated with a fatal prognosis despite intensive supportive care...
  2. doi request reprint Correlation of CYP2C19 phenotype with voriconazole plasma concentration in children
    Atsushi Narita
    Department of Pediatrics, Nagoya University Graduate School of Medicine, Nagoya, Japan
    J Pediatr Hematol Oncol 35:e219-23. 2013
    ..Here, we report an analysis of CYP2C19 phenotype and voriconazole plasma concentrations in children...
  3. doi request reprint Incidence, clinical features, and risk factors of idiopathic pneumonia syndrome following hematopoietic stem cell transplantation in children
    Hirotoshi Sakaguchi
    Department of Pediatrics, Nagoya University Graduate School of Medicine, Nagoya, Japan
    Pediatr Blood Cancer 58:780-4. 2012
    ..Idiopathic pneumonia syndrome (IPS) is a severe complication that can occur after hematopoietic stem cell transplantation (HSCT) and is often associated with a fatal outcome despite intensive supportive care...
  4. pmc Aberrant DNA Methylation Is Associated with a Poor Outcome in Juvenile Myelomonocytic Leukemia
    Hirotoshi Sakaguchi
    Department of Pediatrics, Nagoya University Graduate School of Medicine, Nagoya, Japan
    PLoS ONE 10:e0145394. 2015
    ....
  5. doi request reprint Aberrant phosphorylation of STAT5 by granulocyte-macrophage colony-stimulating factor in infant cytomegalovirus infection mimicking juvenile myelomonocytic leukemia
    Nobuhiro Nishio
    Department of Pediatrics, Nagoya University Graduate School of Medicine, Shouwa ku, Nagoya, Japan
    Leuk Res 35:1261-4. 2011
    ..We conclude that patients with CMV infection cannot be discriminated from patients with JMML by this new diagnostic method...
  6. pmc Paroxysmal nocturnal hemoglobinuria and telomere length predicts response to immunosuppressive therapy in pediatric aplastic anemia
    Atsushi Narita
    Department of Pediatrics, Nagoya University Graduate School of Medicine, Nagoya, Japan
    Haematologica 100:1546-52. 2015
    ..The trial was registered in www.umin.ac.jp with number UMIN000017972. ..
  7. doi request reprint De novo childhood myelodysplastic/myeloproliferative disease with unique molecular characteristics
    Olfat Ismael
    Department of Paediatrics, Nagoya University Graduate School of Medicine, Nagoya, Aichi, Japan
    Br J Haematol 158:129-37. 2012
    ..Moreover, two patients had constitutional alterations of genes frequently found in AML. Further investigations are required to define the roles of these genetic alterations in the pathogenesis of childhood MDS/MPN-U...
  8. doi request reprint Reduced intensity conditioning in allogeneic stem cell transplantation for AML with Down syndrome
    Hideki Muramatsu
    Department of Pediatrics, Nagoya University Graduate School of Medicine, Nagoya, Japan
    Pediatr Blood Cancer 61:925-7. 2014
    ..0% (20.4-96.9%) vs. 10.0% (0.6%-35.8%), p = 0.039)...
  9. doi request reprint Somatic mosaicism for oncogenic NRAS mutations in juvenile myelomonocytic leukemia
    Sayoko Doisaki
    Department of Pediatrics, Nagoya University Graduate School of Medicine, Nagoya, Japan
    Blood 120:1485-8. 2012
    ..These patients are the first reported to have somatic mosaicism for oncogenic NRAS mutations. The clinical course of these patients suggests that NRAS mosaicism may be associated with a mild disease phenotype in JMML...
  10. doi request reprint Molecular lesions in childhood and adult acute megakaryoblastic leukaemia
    Asahito Hama
    Department of Paediatrics, Nagoya University Graduate School of Medicine, Nagoya, Japan
    Br J Haematol 156:316-25. 2012
    ..ASXL1, IDH1/2, DNMT3A, RUNX1 and CBL mutations were not found in any of the patient group studied, while NRAS mutation was identified in two patients with paediatric non-DS-AMKL...
  11. doi request reprint Excellent outcomes of children with CML treated with imatinib mesylate compared to that in pre-imatinib era
    Hideki Muramatsu
    Department of Pediatrics, Nagoya University Graduate School of Medicine, 65 Tsuruma cho, Showa Ku, Nagoya, Aichi 466 8650, Japan
    Int J Hematol 93:186-91. 2011
    ..28.6%, p = 0.006). In summary, the survival outcomes of pediatric patients with CML were dramatically improved by treatment with IM compared to HSCT...
  12. doi request reprint Exome sequencing identifies secondary mutations of SETBP1 and JAK3 in juvenile myelomonocytic leukemia
    Hirotoshi Sakaguchi
    Department of Pediatrics, Nagoya University Graduate School of Medicine, Nagoya, Japan
    Nat Genet 45:937-41. 2013
    ..Our findings provide new insights into the pathogenesis and progression of JMML. ..
  13. doi request reprint Inherited bone marrow failure syndromes in 2012
    Hirotoshi Sakaguchi
    Department of Pediatrics, Nagoya University Graduate School of Medicine, 65 Tsurumai Cho, Showa Ku, Nagoya, Japan
    Int J Hematol 97:20-9. 2013
    ..Multicenter prospective studies are warranted to establish appropriate conditioning regimens aimed at reducing transplant-related mortality...