G T Sukhikh

Summary

Country: Russia

Publications

  1. ncbi request reprint Transplantation of embryonic hepatocytes. Experimental substantiation of a new approach to the therapy of liver failure
    G T Sukhikh
    Laboratory of Clinical Immunology, Research Center for Obstetrics, Gynecology, and Perinatology, Russian Academy of Medical Sciences, Institute of Biological Medicine, Moscow, Russia
    Bull Exp Biol Med 134:519-24. 2002
  2. ncbi request reprint Comparative analysis of the expression of neural stem cell-associated genes during neocortex and retina development in human
    B I Verdiev
    N K Kol tsov Institute of Developmental Biology, Russian Academy of Sciences, Moscow, Russia
    Bull Exp Biol Med 154:529-36. 2013
  3. ncbi request reprint Stem cell transplantation for treatment of liver diseases: from biological foundations to clinical experience (review)
    Gennady T Sukhikh
    Laboratory of Clinical Immunology, Research Center of Obstetrics, Gynecology and Perinatology, Russian Academy of Medical Sciences, Moscow 117815, Russia
    Int J Mol Med 11:395-400. 2003
  4. ncbi request reprint Molecular genetic and immunophenotypical analysis of Pax6 transcription factor and neural differentiation markers in human fetal neocortex and retina in vivo and in vitro
    B I Verdiev
    N K Koltsov Institute of Developmental Biology, The Russian Academy of Sciences, Moscow, Russia
    Bull Exp Biol Med 148:697-704. 2009
  5. ncbi request reprint Disorders in cytokine gene expression in endometrial hyperplasia and effect of hormone therapy
    G T Sukhikh
    Research Center of Obstetrics, Gynecology, and Perinatology, Russian Academy of Medical Sciences, Moscow
    Bull Exp Biol Med 139:235-7. 2005
  6. ncbi request reprint Evaluation of progenitor cell cultures from human embryos for neurotransplantation
    R A Poltavtseva
    Institute of Biological Medicine, Moscow, Russia
    Brain Res Dev Brain Res 134:149-54. 2002
  7. ncbi request reprint In vitro development of neural progenitor cells from human embryos
    R A Poltavtseva
    Institute of Biological Medicine, Russian Academy of Sciences, Moscow
    Bull Exp Biol Med 132:861-3. 2001
  8. ncbi request reprint Methods of detection of mesenchymal stem cells in the kidneys during therapy of experimental renal pathologies
    E Yu Plotnikov
    A N Belozerskii Institute of Physicochemical Biology, M V Lomonosov Moscow Medical University, Moscow, Russia
    Bull Exp Biol Med 154:145-51. 2012
  9. ncbi request reprint Umbilical cord blood mesenchymal stem cells
    R A Musina
    Research Center of Obstetrics, Gynecology, and Perinatology, Russian Academy of Medical Sciences, Moscow
    Bull Exp Biol Med 143:127-31. 2007
  10. ncbi request reprint Optimal detection of serum antipaternal antileukocytic antibodies after injection of allogenic lymphocytes in women with habitual abortions
    L V Krechetova
    VI Kulakov Center of Obstetrics, Gynecology, and Perinatology, Ministry of Health and Social Development of the Russian Federation, Moscow, Russia
    Bull Exp Biol Med 153:726-9. 2012

Collaborators

Detail Information

Publications108 found, 100 shown here

  1. ncbi request reprint Transplantation of embryonic hepatocytes. Experimental substantiation of a new approach to the therapy of liver failure
    G T Sukhikh
    Laboratory of Clinical Immunology, Research Center for Obstetrics, Gynecology, and Perinatology, Russian Academy of Medical Sciences, Institute of Biological Medicine, Moscow, Russia
    Bull Exp Biol Med 134:519-24. 2002
    ..Methods for ex vivo isolation of fetal cells for transplantation are described...
  2. ncbi request reprint Comparative analysis of the expression of neural stem cell-associated genes during neocortex and retina development in human
    B I Verdiev
    N K Kol tsov Institute of Developmental Biology, Russian Academy of Sciences, Moscow, Russia
    Bull Exp Biol Med 154:529-36. 2013
    ..Our experiments showed that genetically determined cell potencies typical of native cells are realized in primary cultures without specific stimulation...
  3. ncbi request reprint Stem cell transplantation for treatment of liver diseases: from biological foundations to clinical experience (review)
    Gennady T Sukhikh
    Laboratory of Clinical Immunology, Research Center of Obstetrics, Gynecology and Perinatology, Russian Academy of Medical Sciences, Moscow 117815, Russia
    Int J Mol Med 11:395-400. 2003
    ..These biological considerations validate the therapeutic manipulations with fetal cells in clinical trials...
  4. ncbi request reprint Molecular genetic and immunophenotypical analysis of Pax6 transcription factor and neural differentiation markers in human fetal neocortex and retina in vivo and in vitro
    B I Verdiev
    N K Koltsov Institute of Developmental Biology, The Russian Academy of Sciences, Moscow, Russia
    Bull Exp Biol Med 148:697-704. 2009
    ..It can be hypothesized that heterotransplantation of the cerebral progenitor cells into the retina of experimental animals can lead to realization of their neurotrophic effect, but not to their functional integration...
  5. ncbi request reprint Disorders in cytokine gene expression in endometrial hyperplasia and effect of hormone therapy
    G T Sukhikh
    Research Center of Obstetrics, Gynecology, and Perinatology, Russian Academy of Medical Sciences, Moscow
    Bull Exp Biol Med 139:235-7. 2005
    ..05) and IL-4 mRNA (p<0.05). Hence, both apoptosis and proliferative activity were suppressed in endometrial hyperplasia, and hormone therapy created prerequisites for transition of the endometrium into the normal proliferation stage...
  6. ncbi request reprint Evaluation of progenitor cell cultures from human embryos for neurotransplantation
    R A Poltavtseva
    Institute of Biological Medicine, Moscow, Russia
    Brain Res Dev Brain Res 134:149-54. 2002
    ..Our results demonstrate that the flow cytometry phenotyping allows the screening and standardization of HNSC samples for further expansion and transplantation...
  7. ncbi request reprint In vitro development of neural progenitor cells from human embryos
    R A Poltavtseva
    Institute of Biological Medicine, Russian Academy of Sciences, Moscow
    Bull Exp Biol Med 132:861-3. 2001
    ..In a serum-containing medium some cells underwent differentiation by the neuronal pathway, while others remained in the stem state...
  8. ncbi request reprint Methods of detection of mesenchymal stem cells in the kidneys during therapy of experimental renal pathologies
    E Yu Plotnikov
    A N Belozerskii Institute of Physicochemical Biology, M V Lomonosov Moscow Medical University, Moscow, Russia
    Bull Exp Biol Med 154:145-51. 2012
    ..Active migration of the cells to the renal tissue was detected by these methods in experimental acute pyelonephritis with inflammation foci...
  9. ncbi request reprint Umbilical cord blood mesenchymal stem cells
    R A Musina
    Research Center of Obstetrics, Gynecology, and Perinatology, Russian Academy of Medical Sciences, Moscow
    Bull Exp Biol Med 143:127-31. 2007
    ..A specific feature of umbilical cord blood mesenchymal stem cells is their low count per volume of the initial material and very low proliferative activity...
  10. ncbi request reprint Optimal detection of serum antipaternal antileukocytic antibodies after injection of allogenic lymphocytes in women with habitual abortions
    L V Krechetova
    VI Kulakov Center of Obstetrics, Gynecology, and Perinatology, Ministry of Health and Social Development of the Russian Federation, Moscow, Russia
    Bull Exp Biol Med 153:726-9. 2012
    ..The results of evaluation of antipaternal antileukocytic antibodies by two modifications of the method are presented. The optimal method for detection of antipaternal antileukocytic antibodies after immunocytotherapy is selected...
  11. ncbi request reprint Neuroprotective effect of mesenchymal and neural stem and progenitor cells on sensorimotor recovery after brain injury
    R A Poltavtseva
    V I Kulakov Research Center of Obstetrics, Gynecology, and Perinatology, Ministry of Health and Social Development of the Russian Federation, Moscow, Russia
    Bull Exp Biol Med 153:586-90. 2012
    ..It should be noted that administration of neural stem and progenitor cells prevented animal death not only in the acute traumatic period, but also in delayed periods...
  12. ncbi request reprint Antisperm antibodies detection by flow cytometry is affected by aggregation of antigen-antibody complexes on the surface of spermatozoa
    M A Nikolaeva
    Laboratory of Clinical Immunology, Russian Scientific Centre for Obstetrics, Gynecology and Perinatology, Moscow, Russia
    Hum Reprod 15:2545-53. 2000
    ..A high probability of Ag-Ab complex shedding from the sperm surface during experimental manipulation limits the use of indirect FCM test for quantitative ASA determination...
  13. ncbi request reprint Expression of carbohydrate metabolism markers in full-term spontaneous and induced pregnancy
    N V Aleksandrova
    Research Center for Obstetrics, Gynecology, and Perinatology, Ministry of Health and Social Development of the Russian Federation, Moscow, Russia
    Bull Exp Biol Med 153:540-4. 2012
    ....
  14. ncbi request reprint Markers of transmembrane and energy exchange in cells of terminal placental villi in spontaneous and induced pregnancy
    N V Alexandrova
    V I Kulakov Research Center of Obstetrics, Gynecology, and Perinatology, Ministry of Health and Social Development of Russian Federation, Moscow, Russia
    Bull Exp Biol Med 153:134-8. 2012
    ..Immunohistochemical analysis revealed pronounced decrease in the expression of markers of transmembrane (α-SNAP 23, annexin 3) and energy (ferritin light chain, ATP5J) in placental terminal villi...
  15. ncbi request reprint In vitro phenotypic modification of pigmented epithelium cells from human eye at early stages of development
    L A Milyushina
    N K Koltsov Institute of Developmental Biology, Russian Academy of Sciences, Moscow, Russia
    Bull Exp Biol Med 148:113-9. 2009
    ....
  16. ncbi request reprint The ratio of cytokine levels in genital herpes during various phases of infection
    A V Shurshalina
    Center of Obstetrics, Gynecology, and Perinatology, Russian Academy of Medical Sciences, Moscow
    Bull Exp Biol Med 132:660-2. 2001
    ..The results suggest that genital herpes is a chronic inflammatory process characterized by high levels of proinflammatory cytokines with predominance of T-helper type 1 over T-helper type 2 cytokines...
  17. doi request reprint Interaction of Lymphocytes with Mesenchymal Stem Cells
    E V Svirshchevskaya
    M M Shemyakin and Yu A Ovchinnikov Institute of Bioorganic Chemistry, Russian Academy of Sciences, Moscow, Russia
    Bull Exp Biol Med 161:571-9. 2016
    ..In neural cultures expressing HLA-DR, all subpopulations of T cells and NK cells were activated. No differences between the autologous and heterologous cultures were revealed. ..
  18. doi request reprint Protection of Neurovascular Unit Cells with Lithium Chloride and Sodium Valproate Prevents Brain Damage in Neonatal Ischemia/Hypoxia
    D N Silachev
    A N Belozersky Institute of Physical and Chemical Biology, Moscow, Russia
    Bull Exp Biol Med 160:313-8. 2016
    ..The results suggest that lithium and sodium valproate can be used for the treatment of neurodegenerative pathologies associated with hypoxia and ischemia in newborns. ..
  19. doi request reprint Detection of Antibodies In Vitro Binding to Endothelial Cells in the Sera from Women with Normal Pregnancy and Preeclampsia
    M M Ziganshina
    V I Kulakov Research Center of Obstetrics, Gynecology, and Perinatology, Ministry of Health of the Russian Federation, Moscow, Russia
    Bull Exp Biol Med 159:475-8. 2015
    ..Flow cytometry detected peculiarities of antibody binding to endothelial cells in health and disease. Detection of antiendothelial antibodies in trimesters II and III can be diagnostically important in preeclampsia...
  20. doi request reprint Caspase expression in placental terminal villi in spontaneous and induced pregnancy
    E A Dubova
    V I Kulakov Research Center of Obstetrics, Gynecology, and Perinatology, the Ministry of Health of the Russian Federation, Moscow, Russia
    Bull Exp Biol Med 158:92-6. 2014
    ..The levels of these caspases in the placental terminal villi were significantly higher in induced pregnancy. The changes were more marked after intracytoplasmatic injection of spermatozoa. ..
  21. ncbi request reprint Morphological characteristics of the terminal villi in placental failure
    E A Dubova
    V I Kulakov Center of Obstetrics, Gynecology, and Perinatology, Ministry of Health and Social Development of the Russian Federation, Moscow, Russia
    Bull Exp Biol Med 155:507-11. 2013
    ..The changes were more pronounced in pregnancy developing after in vitro fertilization. ..
  22. doi request reprint Expression of insulin-like growth factors in the placenta in preeclampsia
    E A Dubova
    V I Kulakov Research Center of Obstetrics, Gynecology, and Perinatology, Ministry of Health of the Russian Federation, Moscow, Russia
    Bull Exp Biol Med 157:103-7. 2014
    ..Low expression of IGF-1 and high expression of IGF-2 and IGFBP-3 in the placental tissue depending on preeclampsia severity were detected. The most pronounced changes were found in preeclampsia associated with small-for-date fetuses...
  23. ncbi request reprint Vascular endothelial growth factor and its receptors in the placental villi of pregnant patients with pre-eclampsia
    E A Dubova
    V I Kulakov Center of Obstetrics, Gynecology, and Perinatology, Ministry of Health and Social Development of the Russian Federation, Moscow, Russia
    Bull Exp Biol Med 154:792-5. 2013
    ..Immunohistochemical studies showed high expression of VEGF and VEGFR-1 and low expression of VEGFR-2 in the placental villous structures...
  24. ncbi request reprint Immunoregulatory properties of human stem cells of mesenchymal and ectodermal origin after their transplantation to BALB/c mice
    P A Karalkin
    V N Orekhovich Research Institute of Biomedical Chemistry, Russian Academy of Medical Sciences, Moscow, Russia
    Bull Exp Biol Med 153:118-23. 2012
    ....
  25. ncbi request reprint Effects of nanostructurized silicon on proliferation of stem and cancer cell
    L A Osminkina
    Physical Faculty, M V Lomonosov Moscow University, Moscow, Russia
    Bull Exp Biol Med 151:79-83. 2011
    ....
  26. ncbi request reprint Immunomorphological characteristics of endometrium in women with chronic endometritis
    G T Sukhikh
    Research Center of Obstetrics, Gynecology, and Perinatology, Russian Academy of Medical Sciences, Moscow
    Bull Exp Biol Med 141:104-6. 2006
    ..These changes are an unfavorable prognositic signs for the onset of pregnancy. Combination therapy improved the phenotypic composition of endometrial cells...
  27. ncbi request reprint Transplantation of cultured human neural stem cells in rabbits with experimental laser-induced damage to the retina
    N V Pak
    Ghelmgolts Moscow Research Institute of Eye Diseases, Russian Ministry of Health, Moscow, Russia
    Bull Exp Biol Med 138:525-8. 2004
    ..Transplanted cells survived, retained multipotent activity, migrated into the zone of injury, and stimulated reparation and regeneration in the traumatized retina...
  28. ncbi request reprint Endometrial mesenchymal stem cells isolated from the menstrual blood
    R A Musina
    V I Kulakov Research Center of Obstetrics, Gynecology, and Perinatology, Russia
    Bull Exp Biol Med 145:539-43. 2008
    ..Specific features of this cell type are high clonogenic activity and low capacity to adipocyte differentiation...
  29. ncbi request reprint The Use of Technetium-99m for Intravital Tracing of Transplanted Multipotent Stromal Cells
    D N Silachev
    V I Kulakov Research Center of Obstetrics, Gynecology, and Perinatology, Ministry of Health of the Russian Federation, Moscow, Russia
    Bull Exp Biol Med 162:153-159. 2016
    ..Visualization of stem cells labeled with Technetium-99m-based preparation by scintigraphy is an objective and highly informative method allowing real-time in vivo cell tracing in the body...
  30. doi request reprint Incidence of Autoantibodies to C1Q Complement Component in Women with Miscarriages and Autoantibodies to Phospholipids and Chorionic Gonadotropin
    I V Menzhinskaya
    V I Kulakov Research Center of Obstetrics, Gynecology, and Perinatology, the Ministry of Health of the Russian Federation, Moscow, Russia
    Bull Exp Biol Med 160:260-3. 2015
    ..Hence, activation of the complement system and hyperproduction of anti-C1q autoantibodies were unfolding in patients with miscarriages, mainly in the patients with autoantibodies to phospholipids. ..
  31. doi request reprint Therapy of Chronic Cardiosclerosis in WAG Rats Using Cultures of Cardiovascular Cells Enriched with Cardiac Stem Cell
    E V Chepeleva
    Institute of Cytology and Genetics, Siberian Division of the Russian Academy of Sciences, Moscow, Russia
    Bull Exp Biol Med 160:165-73. 2015
    ....
  32. doi request reprint The role of the antisperm antibodies in male infertility assessment after microsurgical varicocelectomy
    V A Bozhedomov
    Department of Obstetrics, Gynecology, Perinatology and Reproduction, I M Sechenov First Moscow State Medical University, Moscow, Russia Department of Clinical Andrology, The Federal State Budget Institution Peoples Friendship University of Russia, Moscow, Russia
    Andrology 2:847-55. 2014
    ..05). Thus, antisperm immune response decreases the varicocelectomy efficacy for reproductive function recovery: the higher percentage of ASA and lower grade of varicocele are associated with an unfavourable prognosis...
  33. doi request reprint Cell reconstruction of the rectal mucosa in patients with familial adenomatous polyposis: endoscopy, morphology, immunohistochemistry
    E A Kogan
    V I Kulakov Research Center of Obstetrics, Gynecology, and Perinatology, Ministry of Health of the Russian Federation, Moscow, Russia
    Bull Exp Biol Med 157:683-8. 2014
    ..The proposed treatment of familial colorectal adenomatous polyposis allows delaying the development of rectal polyps and cancer for many years. ..
  34. doi request reprint Expression of immunomodulator gene mRNA in co-culture of mesenchymal stromal cells from the placenta and human mononuclear blood cells
    A M Savilova
    V I Kulakov Research Center of Obstetrics, Gynecology, and Perinatology, Ministry of Health of the Russian Federation, Moscow, Russia
    Bull Exp Biol Med 158:561-5. 2015
    ....
  35. ncbi request reprint Correlation between antibodies to gonadotropin-releasing hormone and reproductive disorders in humans
    I V Menzhinskaya
    V I Kulakov Research Center of Obstetrics, Gynecology, and Perinatology, Ministry of Health Care of the Russian Federation, Moscow, Russia
    Bull Exp Biol Med 155:715-7. 2013
    ..8, respectively). Thus, the presence of antibodies to gonadotropin-releasing hormone was associated with impairments of human reproductive function. ..
  36. ncbi request reprint The expression of matrix metalloproteinases in placental tissue depends on the severity of undifferentiated connective tissue dysplasia
    E A Dubova
    V I Kulakov Research Center of Obstetrics, Gynecology, and Perinatology, Ministry of Health of the Russian Federation, Moscow, Russia
    Bull Exp Biol Med 156:110-3. 2013
    ..The most pronounced elevation of the studied MMP levels was found in the basal plate decidual cells in women with undifferentiated connective tissue dysplasia of more than 18 score. ..
  37. ncbi request reprint Time course of the cytokine profiles during the early period of normal pregnancy and in patients with a history of habitual miscarriage
    M M Ziganshina
    V I Kulakov Research Center of Obstetrics, Gynecology, and Perinatology, the Ministry of Health and Social Development, Moscow, Russia
    Bull Exp Biol Med 154:385-7. 2013
    ....
  38. ncbi request reprint α-Fetoprotein in human fetal vitreous body
    I G Panova
    N K Koltsov Institute of Developmental Biology, Russian Academy of Sciences, Moscow, Russia
    Bull Exp Biol Med 150:420-1. 2011
    ..The concentration of α-fetoprotein was maximum during week 17 of pregnancy (17.4 mg/ml), but then decreased and reached 1.42 mg/ml by week 24...
  39. ncbi request reprint Comparative study of the effects of trophoblastin and polydeoxyribonucleotide preparations on cultured skin fibroblast
    O G Pleshkanyova
    Research Center of Obstetrics, Gynecology, and Perinatology, Federal Agency for High Technology Medical Care, Moscow
    Bull Exp Biol Med 144:154-8. 2007
    ..Polydeoxyribonucleotide had a favorable impact on functioning of basal cell structures at the level of cell nucleus and maintained high level of cells with complete DNA set...
  40. ncbi request reprint Cell biology of fetal tissues and fundamental medicine
    V S Repin
    Center of Obstetrics, Gynecology, and Perinatology, A Ya Friedenstein Institute of Cell Technologies and Regeneration Medicine, Moscow
    Bull Exp Biol Med 144:108-17. 2007
    ..Banks of extraembryonic umbilical blood tissue have been created in Russia. However, the biological and information potentials of fetal/embryonic tissue remain not realized at the theoretical and applied levels...
  41. ncbi request reprint Differentiation potential of mesenchymal stem cells of different origin
    R A Musina
    Research Center for Obstetrics, Gynecology, and Perinatology, Russian Academy of Medical Sciences
    Bull Exp Biol Med 141:147-51. 2006
    ..Presumably, differentiation of mesenchymal stem cells derived from different tissues can differ due to the presence of progenitor cells of different types...
  42. ncbi request reprint Sorsby fundus dystrophy-related mutation in tissue inhibitor of metalloproteinases-3 impairs regulation of its expression in mouse fibroblasts
    G T Sukhikh
    Research Center of Obstetrics, Gynecology, and Perinatology, Russian Academy of Medical Sciences, Moscow
    Bull Exp Biol Med 143:64-7. 2007
    ..The absence of this characteristic in mutant Timp-3S156C is presumably responsible for its accumulation in the extracellular matrix...
  43. doi request reprint Analysis of Neural Stem Cells from Human Cortical Brain Structures In Vitro
    M A Aleksandrova
    N K Kol tsov Institute of Developmental Biology, Russian Academy of Sciences, Moscow, Russia
    Bull Exp Biol Med 161:197-208. 2016
    ..Detailed analysis of neural stem cell populations derived from fetuses on gestation weeks 8-9, 18-20, and 26 expressing Lex/SSEA1 was performed. ..
  44. doi request reprint Intra-Arterial Administration of Multipotent Mesenchymal Stromal Cells Promotes Functional Recovery of the Brain After Traumatic Brain Injury
    D N Silachev
    A N Belozersky Institute of Physicochemical Biology, Moscow, Russia
    Bull Exp Biol Med 159:528-33. 2015
    ..Targeted delivery of multipotent mesenchymal stromal cells into the brain after their injection into the carotid arteries substantially potentiated their neuroprotective effects in traumatic brain injury. ..
  45. doi request reprint Localization and differentiation pattern of transplanted human multipotent mesenchymal stromal cells in the brain of bulbectomized mice
    M M Panchenko
    Laboratory of Cell Mechanisms of Memory Pathology, Institute of Cell Biophysics, Russian Academy of Sciences, Moscow, Russia
    Bull Exp Biol Med 158:118-22. 2014
    ..However, some of these cells differentiated into astrocytes, which brought us to an assumption on important role of astroglial abnormalities in the pathogenesis of Alzheimer's disease. ..
  46. doi request reprint Spectrum of antibodies to reproductive hormones in threatened abortion
    I V Menzhinskaya
    V I Kulakov Research Center of Obstetrics, Gynecology, and Perinatology, the Ministry of Health of Russia, Moscow, Russia
    Bull Exp Biol Med 157:747-50. 2014
    ..Presumably, antibodies to chorionic gonadotropin and gonadotropin-releasing hormone could serve as independent factors of threatened abortion risk during trimester I. ..
  47. ncbi request reprint Characteristics of cardiac cell cultures derived from human myocardial explants
    S V Pavlova
    Institute of Cytology and Genetics, Siberian Division of the Russian Academy of Sciences Institute of Chemical Biology and Fundamental Medicine, Siberian Division of the Russian Academy of Sciences, Novosibirsk E N Meshalkin Research Institute of Circulatory Pathology, Ministry of Health of the Russian Federation, Novosibirsk V I Kulakov Research Center of Obstetrics, Gynecology, and Perinatology, Ministry of Health of the Russian Federation, Moscow, Russia
    Bull Exp Biol Med 156:127-35. 2013
    ..The presence of microvascular cells determined general angiogenic potential of the culture...
  48. ncbi request reprint Ratio between the number of Th1 and Th2 lymphocytes in the peripheral blood and concentration of proinflammatory cytokines in lochia of women with postpartum endometritis
    G T Sukhikh
    Research Center of Obstetrics, Gynecology, and Perinatology, Russian Academy of Medical Sciences, Moscow
    Bull Exp Biol Med 140:672-4. 2005
    ..4 and 2.7 times, respectively). The concentrations of cytokines IL-1beta, TNF-alpha, and IL-6 increased most significantly in patients with postpartum endometritis and active viral infection (by 3.4, 4.2, and 1.6 times, respectively)...
  49. ncbi request reprint Expression of antiangiogenic factors in the placental structures in pre-eclampsia
    A I Shchyogolev
    V I Kulakov Research Center of Obstetrics, Gynecology, and Perinatology, the Ministry of Health and Social Development of the Russian Federation, Moscow, Russia
    Bull Exp Biol Med 154:287-91. 2012
    ..The intensity of endoglin and VEGFR1 expression was maximum in the syncytiotrophoblast and extravillous cytotrophoblast cells in severe pre-eclampsia...
  50. ncbi request reprint Protamine and fertilin mRNA: potential biomarkers of assisted reproductive technology outcomes
    G T Sukhikh
    V I Kulakov Center of Obstetrics, Gynecology, and Perinatology, the Ministry of Health and Social Development of the Russian Federation, Moscow, Russia
    Bull Exp Biol Med 153:513-5. 2012
    ..The levels of seminal gene expression are potential predictors of the efficiency of in vitro fertilization and embryo transfer...
  51. ncbi request reprint Peroxisome proliferator-activated receptors of trophoblast cells in miscarriage
    N V Alexandrova
    V I Kulakov Research Center of Obstetrics, Gynecology, and Perinatology, Ministry of Health Care and Social Development of the Russian Federation, Russia
    Bull Exp Biol Med 152:768-71. 2012
    ..Immunohistochemical assay showed enhanced expression of PPARγ and increased proliferation index (Ki-67) in cells of the villous and extravillous trophoblasts in missed abortion...
  52. ncbi request reprint Expression of transforming growth factor-β2in vitreous body and adjacent tissues during prenatal development of human eye
    G T Sukhikh
    N K Kol tsov Institute of Developmental Biology, Russian Academy of Sciences, Moscow, Russia
    Bull Exp Biol Med 150:117-21. 2010
    ....
  53. ncbi request reprint Behavior of human neural progenitor cells transplanted to rat brain
    M A Aleksandrova
    Institute of Development Biology, Russian Academy of Sciences, Moscow, Russia
    Brain Res Dev Brain Res 134:143-8. 2002
    ..Our results demonstrate that cultured human neural stem/progenitor cells migrate and differentiate into both neurons and astrocytes after transplantation to the rat forebrain or cerebellum of young and adult rats...
  54. ncbi request reprint Morphofunctional study of the therapeutic efficacy of human mesenchymal and neural stem cells in rats with diffuse brain injury
    A F Tsyb
    Medical Radiological Research Center, Russian Academy of Medical Sciences, Obninsk, Russia
    Bull Exp Biol Med 147:132-46. 2009
    ..Adult mesenchymal stem cells had a strong effect on recovery of the vascular bed in ischemic regions...
  55. ncbi request reprint Effect of xenotransplantation of cell cultures enriched with stem and progenitor cells on hormonal profile of rats with abdominal cryptorchism
    G T Sukhikh
    V I Kulakov Research Center of Obstetrics, Gynecology, and Perinatology, Federal Agency of Medical Technologies, Russia
    Bull Exp Biol Med 146:517-21. 2008
    ....
  56. ncbi request reprint Organotypic cultures of free-floating slices of human embryo medulla oblongata
    V M Vostrikov
    Clinical Neuromorphology Laboratory, Scientific Center for Mental Health, Russian Academy of Medical Sciences, Moscow
    Neurosci Behav Physiol 35:9-15. 2005
    ....
  57. ncbi request reprint Effect of cell therapy on recovery of cognitive functions in rats during the delayed period after brain injury
    L M Roshal
    Research Institute of Emergency Pediatric Surgery and Traumatology, Department of Public Health Services, Moscow, Russia
    Bull Exp Biol Med 148:140-7. 2009
    ..Fetal neural stem cells had a stronger effect on some parameters of cognitive function 2 months after brain injury. The efficacy of bone marrow mesenchymal stem cells from adult humans or fetuses was higher 3 months after brain injury...
  58. ncbi request reprint Application potential of human fetal stem/progenitor cells in cell therapy
    G T Sukhikh
    Research Center of Obstetrics, Gynecology, and Perinatology, Federal Agency of Medical Technologies, Moscow
    Bull Exp Biol Med 145:114-21. 2008
    ..The main tissue sources of fetal stem cells are characterized and experimental and clinical data on the use of fetal cells for cytotherapy are presented...
  59. ncbi request reprint Serum activity of matrix metalloproteinases -2 and -9
    G M Soboleva
    Research Center of Obstetrics, Gynecology, and Perinatology, Russian Academy of Medical Sciences, Moscow
    Bull Exp Biol Med 141:247-9. 2006
    ..Measurements of serum activities of matrix metalloproteinases -2 and -9 are proposed for monitoring of the dynamics and treatment efficiency in chronic endometritis...
  60. ncbi request reprint Heterogeneity of serum activities of matrix metalloproteinases in chronic endometritis
    G T Sukhikh
    Research Center of Obstetrics, Gynecology, and Perinatology, Russian Academy of Medical Sciences, Moscow
    Bull Exp Biol Med 143:476-8. 2007
    ..We measured serum levels of metalloproteinases in patients with chronic endometritis concomitant with sterility and its changes during the first days after magnetotherapy...
  61. doi request reprint Antiproliferative Effects of Mesenchymal Stem Cells and Epithelial Cells on Lymphocytes
    E V Svirshchevskaya
    M M Shemyakin and Yu A Ovchinnikov Institute of Bioorganic Chemistry, Russian Academy of Sciences, Moscow, Russia
    Bull Exp Biol Med 161:518-22. 2016
    ..This suppression can be determined by impairment of normal adhesion contacts between cells of different origin. ..
  62. doi request reprint Mesenchymal stem cells from human dental pulp: isolation, characteristics, and potencies of targeted differentiation
    R A Poltavtseva
    V I Kulakov Research Center of Obstetrics, Gynecology, and Perinatology, Ministry of Health of the Russian Federation, Moscow, Russia
    Bull Exp Biol Med 158:164-9. 2014
    ..Under in vitro conditions, dental pulp cells were more susceptible to factors inducing their differentiation into adipogenic, chondrogenic, and osteogenic lineage cells. ..
  63. ncbi request reprint Therapeutic effect of mesenchymal multipotent stromal cells on memory in animals with Alzheimer-type neurodegeneration
    N V Bobkova
    Institute of Cell Biophysics, Russian Academy of Science V I Kulakov Research Center of Obstetrics, Gynecology, and Perinatology, Ministry of Health Care of the Russian Federation, Moscow, Russia
    Bull Exp Biol Med 156:119-21. 2013
    ..These findings indicate prospects of using mesenchymal multipotent stromal cells for the therapy of Alzheimer disease and the possibility of their systemic administration for attaining the therapeutic effect. ..
  64. doi request reprint Isolation of mesenchymal stromal cells from extraembryonic tissues and their characteristics
    V N Veryasov
    V I Kulakov Research Center of Obstetrics, Gynecology, and Perinatology, Ministry of Health of the Russian Federation, Moscow, Russia
    Bull Exp Biol Med 157:119-24. 2014
    ..The isolated cells met the criteria for multipotent mesenchymal stem cells. ..
  65. doi request reprint Association of ESR1 gene polymorphism with preterm rupture of fetal membranes
    N E Kan
    V I Kulakov Research Center of Obstetrics, Gynecology, and Perinatology, the Ministry of Health of the Russian Federation, Moscow, Russia
    Bull Exp Biol Med 156:841-4. 2014
    ..These data attest to an important role of fetal genotype in the formation of genetic predisposition to preterm rupture of fetal membranes. ..
  66. ncbi request reprint Suppressed production of transforming growth factor-beta(2)mRNA in endometrium of women with polycystic ovary syndrome
    A V Zhdanov
    Research Center of Obstetrics, Gynecology, and Perinatology, Russian Academy of Medical Sciences, Moscow
    Bull Exp Biol Med 131:276-8. 2001
    ..Low production of transforming growth factor-beta(2)mRNA probably contributes to the development of endometrial hyperplasia in women with polycystic ovary syndrome...
  67. ncbi request reprint Cardiotropic effect of extracardiac transplantation of embryonic human myoblasts to mice with bradycardia: various effects of cell material
    V N Yarygin
    Russian State Medical University, Moscow, Russia
    Bull Exp Biol Med 139:129-33. 2005
    ..These data attest to a variety of biological effects of stem cells and/or their derivatives and to ambiguous mechanisms of these effects...
  68. doi request reprint Identification of some human genes oppositely regulated during esophageal squamous cell carcinoma formation and human embryonic esophagus development
    M V Zinovyeva
    Laboratory of Structure and Functions of Human Genes, Shemyakin Ovchinnikov Institute of Bioorganic Chemistry, Russian Academy of Sciences, Moscow, Russia
    Dis Esophagus 23:260-70. 2010
    ..This tumor 'embryonization' supports the idea that stem or progenitor cells are implicated in esophageal cancer emergence...
  69. ncbi request reprint Genetic aberrations in tissue inhibitor of metalloproteinases-3 lead to manifestations of the myofibroblast phenotype in mouse fibroblasts and fibroblasts of patients with Sorsby fundus dystrophy
    G M Soboleva
    Research Center of Obstetrics, Gynecology, and Perinatology, Russian Academy of Medical Sciences
    Bull Exp Biol Med 143:231-5. 2007
    ....
  70. ncbi request reprint Expression and intracellular localization of ACA and TRA-1-81 in smooth muscle cell tumors
    G T Sukhikh
    V I Kulakov Research Center of Obstetrics, Gynecology, and Perinatology, Ministry of Health of the Russian Federation, Moscow, Russia ACA CELL Biotech, Heidelberg, Germany
    Bull Exp Biol Med 155:530-5. 2013
    ....
  71. doi request reprint Male fertility and varicocoele: role of immune factors
    V A Bozhedomov
    Department of Obstetrics, Gynecology, Perinatology and Reproduction, I M Sechenov First Moscow State Medical University, Moscow, Russia Department of Clinical Andrology, The Federal State Budget Institution Peoples Friendship University of Russia, Moscow, Russia Federal State Budget Institution Polyclinic No 1 of the Business Administration for the President of the Russian Federation, Moscow, Russia
    Andrology 2:51-8. 2014
    ..8 and 3.5 times higher than in ASA-negative varicocoele patients and fertile men respectively. We did not find correlation between the grade of spermatic cord vein dilatation and ROS production. ..
  72. ncbi request reprint Myosin-activating protein kinases are possible regulators of nonmuscle myosin in developing human heart
    O V Stepanova
    Institute of Clinical Cardiology, Russian Cardiology Research and Production Center, Ministry of Health Care and Social Development of the Russian Federation, Moscow, Russia
    Bull Exp Biol Med 152:198-201. 2011
    ..In this case, the approximate time period of changes in these isoforms ratio was revealed (between 8-9 and 13 weeks), that can be associated with functional changes in the developing myocardium...
  73. ncbi request reprint Cell transplantation in surgical treatment of familial adenomatous polyposis coli
    G I Vorobyov
    Research Center of Coloproctology, Ministry of Health and Social Development of the Russian Federation, Moscow, Russia
    Bull Exp Biol Med 150:519-21. 2011
    ..Complex examination 4 weeks after surgery revealed the formation of normal rectal mucosa. No new polyps were detected in the rectum 1-3 years after surgery...
  74. ncbi request reprint Apoptosis in woman uterine cervix in pathologies associated with human papillomavirus
    S I Rogovskaya
    Research Center of Obstetrics, Gynecology and Perinatology, Russian Academy of Medical Sciences; Institute of Biological Medicine, Moscow
    Bull Exp Biol Med 131:576-82. 2001
    ..The prevalence of human papillomavirus infection directly correlated with neoplastic changes in the cervical epithelium...
  75. ncbi request reprint Free radical generation in ejaculate samples from infertile patients
    I V Korotkova
    Laboratory of Clinical Immunology, Research Center of Obstetrics, Gynecology, and Perinatology, Russian Academy of Medical Sciences
    Bull Exp Biol Med 131:555-7. 2001
    ..The presence of antisperm antibodies in samples increased the possibility of damages to spermatozoon plasma membranes due to excessive generation of free radicals...
  76. ncbi request reprint Heterogeneity of mitochondrial potential as a marker for isolation of pure cardiomyoblast population
    T G Khryapenkova
    Faculty of Bioengineering and Bioinformatics, A N Belozerskii Institute of Physicochemical Biology, M V Lomonosov Moscow State University, Moscow, Russia
    Bull Exp Biol Med 146:506-11. 2008
    ..These results open possibilities for the development of a new specific method for isolation of cardiomyocyte culture from fetal and embryonic sources for their further use in clinical practice...
  77. ncbi request reprint Comparison of mesenchymal stem cells obtained from different human tissues
    R A Musina
    Research Center of Obstetrics Gynecology, and Perinatology, Russian Academy of Medical Sciences, Moscow
    Bull Exp Biol Med 139:504-9. 2005
    ..Mesemchymal stem cells of the studied tissues during isolation and culturing were morphologically similar and did not differ by the expression of the main marker genes...
  78. ncbi request reprint Correlations in the cytokine system in endometrial hyperplasia
    A V Zhdanov
    Research Center of Obstetrics, Gynecology, and Perinatology, Russian Academy of Medical Sciences, Moscow
    Bull Exp Biol Med 136:270-2. 2003
    ..Dufastone and zoladex therapy did not lead to recovery of this balance, but higher correlations between the expression of some factors of cell proliferation attest to the beginning of normalization of pathologically changed endometrium...
  79. ncbi request reprint The significance of angiogenic growth factor in the pathogenesis of gestosis in pregnant women with varicose disease
    A V Sokolyan
    Department of Obstetrics, Gynecology, and Perinatology, Faculty of Upgrading of Pediatricians, I M Setchenov Moscow Medical Academy, Russia
    Bull Exp Biol Med 145:480-2. 2008
    ..In pregnant patients with varicose disease, a less pronounced increase in this parameter was observed in comparison with that in healthy women...
  80. ncbi request reprint Cytokine production by immunocompetent cells of peritoneal fluid in women with external genital endometriosis
    G T Sukhikh
    State Research Center of Obstetrics, Gynecology, and Perinatology, Russian Academy of Medical Sciences, Moscow, Russia
    Bull Exp Biol Med 137:568-71. 2004
    ..The concentrations of IFN-gamma in the peritoneal fluid did not change in endometriosis, but increased in the supernatants of peritoneal lymphocyte cultures...
  81. ncbi request reprint Immunohistochemical study of fetal stem/progenitor cells from human brain transplanted into traumatized spinal cord of adult rats
    O V Podgornyi
    N K Koltsov Institute of Developmental Biology, Russian Academy of Sciences, Moscow
    Bull Exp Biol Med 137:415-8. 2004
    ..Human neural stem/progenitor cells were viable for not less than 3 months. They migrated and differentiated into neurons and glia in the traumatized spinal cord of adult rats...
  82. ncbi request reprint Human fetal neural stem cells in rat brain: effects of preculturing and transplantation
    A V Revishchin
    Institute of Problems of Ecology and Evolution, Russian Academy of Sciences, Moscow
    Bull Exp Biol Med 139:213-6. 2005
    ..After transplantation of long-cultured cells into the brain mainly committed neuroblasts and solitary nestin-positive cells migrated from the site of transplantation into the brain...
  83. ncbi request reprint Structure of cell clusters formed in cultures of dissociated human embryonic brain
    A V Revishchin
    Institute of Gene Biology, Russian Academy of Sciences, Moscow
    Bull Exp Biol Med 132:856-60. 2001
    ..Stem cells were localized on the surface of clusters. The percentage of stem cells in large clusters was lower than in small clusters...
  84. ncbi request reprint Development of neural stem/progenitor cells from human brain by transplantation into the brains of adult rats
    M A Aleksandrova
    Laboratory of Experimental Neurobiology, Institute of Developmental Biology, Russian Academy of Sciences, Russia
    Neurosci Behav Physiol 34:659-62. 2004
    ..Cells from suspension transplants migrated intensely and differentiated into neurons and gliocytes. At the same time, transplants of whole neurospheres showed limited or no migration because of the development of a glial barrier...
  85. ncbi request reprint Comparative analysis of differentiation and behavior of human neural and mesenchymal stem cells in vitro and in vivo
    M A Aleksandrova
    Institute of Developmental Biology, Russian Academy of Sciences
    Bull Exp Biol Med 141:152-60. 2006
    ..Recipient filaments grew into mesenchymal stem cell transplants containing no neural cells due to local changes in the extracellular matrix at the site of transplantation...
  86. ncbi request reprint Xenotransplantation of stem/progenitor cells from human fetal brain to adult rats with spinal trauma
    G A Stepanov
    Central Institute of Traumatology and Orthopedics, Moscow
    Bull Exp Biol Med 135:397-400. 2003
    ..Human neural stem/progenitor cells were viable, migrated, and differentiated into neurons and glia in the traumatized spinal cord in adult rats...
  87. ncbi request reprint Human neural stem cells normalize rat behavior after hypoxia
    O V Podgornyi
    N K Koltsov Institute of Developmental Biology, Russian Academy of Sciences Institute of Higher Nervous Activity and Neurophysiology, Russian Academy of Sciences, Moscow
    Bull Exp Biol Med 137:348-51. 2004
    ..They normalized animal behavior and improved conditioning in two-way avoidance response paradigm in a shuttle box...
  88. ncbi request reprint [Development of human brain neural/progenitor cells after transplantation into the brain of adult rats]
    M A Aleksandrova
    Laboratory of Experimental Neurobiology, Institute of Developmental Biology, RAS, Moscow
    Morfologiia 123:17-20. 2003
    ..Cells from suspension transplants actively migrated and differentiated into neurons and glial cells. Meanwhile, cell migration from the transplanted whole neurospheres was limited or absent due to the formation of glial barrier...
  89. ncbi request reprint [Transplantation of stem/progenitor cells of human brain into the brain of adult rats]
    M A Aleksandrova
    Kol tsov Institute of Developmental Biology, Russian Academy of Sciences, ul Vavilova 26, Moscow, 119991 Russia
    Ontogenez 34:167-73. 2003
    ..Some growing nerve cells had long processes with growth cones. At the same time, some transplanted cells retained the undifferentiated state within one month after the implantation, as shown by the vimentin expression...
  90. ncbi request reprint Structure and cell composition of spheres cultured from human fetal retina
    M A Aleksandrova
    N K Koltsov Institute of Developmental Biology, Russian Academy of Sciences, Moscow
    Bull Exp Biol Med 142:152-9. 2006
    ..All spheres, irrespective of age and duration of culturing, consisted of numerous cell rosettes, each histotypically similar to the neuroblastic layer of the developing retina...
  91. ncbi request reprint Functional aftereffects of intraparenchymatous injection of human fetal stem and progenitor cells to rats with chronic and acute renal failure
    V I Kirpatovskii
    Institute of Urology, Russian Ministry of Health, Moscow
    Bull Exp Biol Med 141:500-6. 2006
    ....
  92. ncbi request reprint Effect of transplantation of cultured human neural stem and progenitor cells on regeneration of the cornea after chemical burn
    S L Kuznetsov
    I M Setchenov Moscow Medical Academy
    Bull Exp Biol Med 141:129-32. 2006
    ..A single subconjunctival injection of cell culture suspension after burn injury significantly accelerated regeneration of the anterior and posterior epithelium in comparison with the control group...
  93. ncbi request reprint [Transplantation of neural stem cells in experimental retinopathy]
    N V Pak
    Vestn Oftalmol 120:21-4. 2004
    ..An evaluation of the functional activity of the retina denoted a reliably better function of rod bipolars and Muller glias in the eyes with transplanted NSCs during the whole follow-up...
  94. ncbi request reprint Formation of neuroepithelial structures in culture of neural stem cells from human brain
    O V Podgornyi
    N K Kol tsov Institute of Developmental Biology, Russian Academy of Sciences, Moscow
    Bull Exp Biol Med 140:113-7. 2005
    ..These cells express nestin, a marker of neural stem cells. The cells in "rosettes" found after transplantation have similar characteristics...
  95. ncbi request reprint In vivo and in vitro proliferative and differentiation activity of human embryonic retinal cells
    I G Panova
    N K Koltsov Institute of Developmental Biology, Russian Academy of Sciences, Russia
    Bull Exp Biol Med 139:517-22. 2005
    ..Culturing was accompanied by the formation of aggregates and neurospheres, where mitoses and progenitor or differentiated cells expressing markers of photoreceptors, neurons, and glia were found...
  96. ncbi request reprint [Neural stem and progenitor cells of human embryos and fetuses as a basis of biomedical new technologies]
    R A Poltavtseva
    Kol tsov Institute of Developmental Biology, Russian Academy of Sciences, ul Vavilova 26, Moscow, 119991 Russia
    Ontogenez 34:211-5. 2003
    ..In most neurospheres, the nestin-immunopositive cells were located near the surface while the cells stained for beta-tubulin III and glial fibrillar acid protein, as compact groups inside the neurospheres...
  97. ncbi request reprint Transplantation of cultured neural cells from human fetuses into the brain of rats exposed to acute hypoxia
    M A Aleksandrova
    N K Koltsov Institute of Developmental Biology, Russian Academy of Sciences, Moscow
    Bull Exp Biol Med 137:262-5. 2004
    ..The transplants and brain tissue were not separated with a glial barrier. Human neuroblasts widely migrated into regions of neuronal degeneration in the host brain...
  98. ncbi request reprint [Mesenchymal progenitor cells. Biological characteristic and prospects for their use]
    G T Sukhikh
    Fiziol Zh 53:62-76. 2007
    ..Prospects of clinical use of mesenchymal stem cells for the treatment of degenerative arthritis, spinal cord injuries, myocardial infarction and other disorders are shown...
  99. ncbi request reprint Functional activity of mitochondria in cultured neural precursor cells
    E Yu Plotnikov
    A N Belozvorskii Institute of Physico Chemical Biology, M V Lomonosov Moscow State University
    Bull Exp Biol Med 141:142-6. 2006
    ..These data will help to create optimum conditions for culturing of neural stem cells for the maintenance of their maximum functional and proliferative activity...
  100. ncbi request reprint [Gene-engineering technologies and stem cells]
    N Ia Spivak
    Fiziol Zh 54:92-104. 2008
    ..Special attention is focused on the problem of biosecurity ensuring...
  101. ncbi request reprint [Organotypic cultures of free-floating sections of human embryonic medulla oblongata]
    V M Vostrikov
    Laboratory of Clinical Neuromorphology, RAMS Scientific Center of Mental Health, Moscow
    Morfologiia 124:41-7. 2003
    ....