M V Shepelev

Summary

Country: Russia

Publications

  1. doi The RHOV gene is overexpressed in human non-small cell lung cancer
    Mikhail V Shepelev
    Laboratory of Molecular Oncogenetics, Institute of Gene Biology, Russian Academy of Sciences, Moscow, Russian Federation Electronic address
    Cancer Genet 206:393-7. 2013
  2. doi LY294002 enhances expression of proteins encoded by recombinant replication-defective adenoviruses via mTOR- and non-mTOR-dependent mechanisms
    Mikhail V Shepelev
    Institute of Gene Biology, Russian Academy of Sciences, 34 5 Vavilov Street, Moscow, 119334, Russia
    Mol Pharm 10:931-9. 2013
  3. doi Pak6 protein kinase is a novel effector of an atypical Rho family GTPase Chp/RhoV
    M V Shepelev
    Institute of Gene Biology, Russian Academy of Sciences, Moscow, Russia
    Biochemistry (Mosc) 77:26-32. 2012
  4. doi [Selection of microRNA for providing tumor specificity of transgene expression in cancer gene therapy]
    M V Shepelev
    Institute of Gene Biology, Russian Academy of Sciences, Moscow, 119334, Russia
    Mol Biol (Mosk) 50:327-35. 2016
  5. doi mTOR-dependent transcriptional repression of Pdcd4 tumor suppressor in lung cancer cells
    P N Vikhreva
    Institute of Gene Biology, Russian Academy of Sciences, 34 5 Vavilov Str, Moscow 119334, Russia
    Biochim Biophys Acta 1839:43-9. 2014

Collaborators

  • P N Vikhreva
  • I V Korobko

Detail Information

Publications5

  1. doi The RHOV gene is overexpressed in human non-small cell lung cancer
    Mikhail V Shepelev
    Laboratory of Molecular Oncogenetics, Institute of Gene Biology, Russian Academy of Sciences, Moscow, Russian Federation Electronic address
    Cancer Genet 206:393-7. 2013
    ..We propose that the RHOV gene could be validated as a diagnostic or prognostic marker for NSCLC, and that observed overexpression of RHOV might contribute to tumorigenesis. ..
  2. doi LY294002 enhances expression of proteins encoded by recombinant replication-defective adenoviruses via mTOR- and non-mTOR-dependent mechanisms
    Mikhail V Shepelev
    Institute of Gene Biology, Russian Academy of Sciences, 34 5 Vavilov Street, Moscow, 119334, Russia
    Mol Pharm 10:931-9. 2013
    ....
  3. doi Pak6 protein kinase is a novel effector of an atypical Rho family GTPase Chp/RhoV
    M V Shepelev
    Institute of Gene Biology, Russian Academy of Sciences, Moscow, Russia
    Biochemistry (Mosc) 77:26-32. 2012
    ..Taking the data together, we report here the identification of p21-activated kinase Pak6 as a novel effector of the atypical Rho GTPase Chp. Our data suggest further directions in elucidating biological functions of these proteins...
  4. doi [Selection of microRNA for providing tumor specificity of transgene expression in cancer gene therapy]
    M V Shepelev
    Institute of Gene Biology, Russian Academy of Sciences, Moscow, 119334, Russia
    Mol Biol (Mosk) 50:327-35. 2016
    ..It is suggested that this should be done directly in the cancer gene therapy scheme with monitoring of the therapeutic transgene activity. ..
  5. doi mTOR-dependent transcriptional repression of Pdcd4 tumor suppressor in lung cancer cells
    P N Vikhreva
    Institute of Gene Biology, Russian Academy of Sciences, 34 5 Vavilov Str, Moscow 119334, Russia
    Biochim Biophys Acta 1839:43-9. 2014
    ..In conclusion, we described a novel molecular mechanism of Pdcd4 suppression in cancer cells consisting from mTOR signaling-dependent transcriptional repression of Pdcd4. ..