Sergey V Razin

Summary

Affiliation: Medical School
Country: Russia

Publications

  1. doi request reprint Communication of genome regulatory elements in a folded chromosome
    Sergey V Razin
    Institute of Gene Biology of the Russian Academy of Sciences, 119334 Moscow, Russia
    FEBS Lett 587:1840-7. 2013
  2. pmc Spatial configuration of the chicken alpha-globin gene domain: immature and active chromatin hubs
    Alexey A Gavrilov
    Laboratory of Structural and Functional Organization of Chromosomes, Institute of Gene Biology of the Russian Academy of Sciences, 34 5 Vavilov Street, 119334 Moscow, Russia
    Nucleic Acids Res 36:4629-40. 2008
  3. doi request reprint The inactivation of the π gene in chicken erythroblasts of adult lineage is not mediated by packaging of the embryonic part of the α-globin gene domain into a repressive heterochromatin-like structure
    Elena S Ioudinkova
    Department of Structural and Functional Organization of Chromosomes, Institute of Gene Biology of the Russian Academy of Sciences, Moscow, Russia
    Epigenetics 6:1481-8. 2011
  4. doi request reprint Repositioning of ETO gene in cells treated with VP-16, an inhibitor of DNA-topoisomerase II
    Mikhail A Rubtsov
    Laboratory of Structural and Functional Organization of Chromosomes, Institute of Gene Biology of the Russian Academy of Sciences, 34 5 Vavilov Street, 119334 Moscow, Russia
    J Cell Biochem 104:692-9. 2008
  5. pmc TMEM8 - a non-globin gene entrapped in the globin web
    Elena S Philonenko
    Institute of Gene Biology of the Russian Academy of Sciences, Vavilov Street 34 5, 119334 Moscow, Russia
    Nucleic Acids Res 37:7394-406. 2009
  6. pmc Mapping of the nuclear matrix-bound chromatin hubs by a new M3C experimental procedure
    Alexey A Gavrilov
    Laboratory of Structural and Functional Organization of Chromosomes, Institute of Gene Biology of the Russian Academy of Sciences, 34 5 Vavilov Street, 119334 Moscow, Russia
    Nucleic Acids Res 38:8051-60. 2010
  7. doi request reprint Early replication timing of the chicken alpha-globin gene domain correlates with its open chromatin state in cells of different lineages
    Denis B Klochkov
    Institute of Gene Biology, Russian Academy of Sciences, Vavilov Street 34 5, 119334 Moscow, Russia
    Genomics 93:481-6. 2009
  8. pmc Disclosure of a structural milieu for the proximity ligation reveals the elusive nature of an active chromatin hub
    Alexey A Gavrilov
    Institute of Gene Biology of the Russian Academy of Sciences, 119334 Moscow, Russia, University of Oslo, Center for Medical Studies in Russia, 119334 Moscow, Russia
    Nucleic Acids Res 41:3563-75. 2013
  9. pmc Quantitative analysis of genomic element interactions by molecular colony technique
    Alexey A Gavrilov
    Group of Genome Spatial Organization, Institute of Gene Biology of the Russian Academy of Sciences, Moscow 119334, Russia, Laboratory of Viral RNA Biochemistry, Institute of Protein Research of the Russian Academy of Sciences, Pushchino, Moscow Region 142290, Russia, Laboratory of Cell Proliferation Problems, Koltzov Institute of Developmental Biology of the Russian Academy of Sciences, Moscow 119334, Russia, Laboratory of Structural and Functional Organization of Chromosomes, Institute of Gene Biology of the Russian Academy of Sciences, Moscow 119334, Russia and Faculty of Biology, M V Lomonosov Moscow State University, Moscow 119992, Russia
    Nucleic Acids Res 42:e36. 2014
  10. pmc A CTCF-dependent silencer located in the differentially methylated area may regulate expression of a housekeeping gene overlapping a tissue-specific gene domain
    Denis Klochkov
    Laboratory of Structural Functional Organization of Chromosomes, Institute of Gene Biology of the Russian Academy of Sciences, 34 5 Vavilov Street, 117334 Moscow, Russia
    Mol Cell Biol 26:1589-97. 2006

Collaborators

  • Alexey Gavrilov
  • Maria D Logacheva
  • Yuri Y Shevelyov
  • Ekaterina E Khrameeva
  • Helena V Chetverina
  • Felix Recillas-Targa
  • Omar L Kantidze
  • Artem K Velichko
  • Olga V Iarovaia
  • Sergey V Ulianov
  • Elena S Ioudinkova
  • Denis B Klochkov
  • Elena S Philonenko
  • Arkadiy K Golov
  • Nadezhda V Petrova
  • Elena N Markova
  • Andrey A Bystritskiy
  • Mikhail A Rubtsov
  • Yegor S Vassetzky
  • Olga N Umanskaya
  • Denis Klochkov
  • Natalia V Petrova
  • Victoria Borunova
  • Mikhail S Gelfand
  • Alexander Chertovich
  • Elena A Mikhaleva
  • Maxim V Imakaev
  • Pavel Kos
  • Aleksey A Penin
  • Ilya M Flyamer
  • Daria Bunina
  • Victoria V Borunova
  • Sergey M Terekhov
  • Irina I Yakutenko
  • Svetlana S Lebedeva
  • Héctor Rincón-Arano
  • Viviana Valadez-Graham
  • Valentin A Verbovoy
  • Andrey Bystritskiy
  • Dmitrii Ravcheev
  • Ronald Hancock

Detail Information

Publications27

  1. doi request reprint Communication of genome regulatory elements in a folded chromosome
    Sergey V Razin
    Institute of Gene Biology of the Russian Academy of Sciences, 119334 Moscow, Russia
    FEBS Lett 587:1840-7. 2013
    ..The interconnection between the functionally dependent architecture of the interphase chromosome and nuclear compartmentalization is also discussed...
  2. pmc Spatial configuration of the chicken alpha-globin gene domain: immature and active chromatin hubs
    Alexey A Gavrilov
    Laboratory of Structural and Functional Organization of Chromosomes, Institute of Gene Biology of the Russian Academy of Sciences, 34 5 Vavilov Street, 119334 Moscow, Russia
    Nucleic Acids Res 36:4629-40. 2008
    ..These incomplete chromatin hubs were present in proliferating cultured erythroblasts which did not express globin genes. In lymphoid cells only the interaction between the alpha(D) promoter and the CpG island was detected...
  3. doi request reprint The inactivation of the π gene in chicken erythroblasts of adult lineage is not mediated by packaging of the embryonic part of the α-globin gene domain into a repressive heterochromatin-like structure
    Elena S Ioudinkova
    Department of Structural and Functional Organization of Chromosomes, Institute of Gene Biology of the Russian Academy of Sciences, Moscow, Russia
    Epigenetics 6:1481-8. 2011
    ..This conclusion is supported by the demonstration that in chicken erythroblasts of adult lineage, the embryonal and adult segments of the α-globin gene domain show similar elevated sensitivities to DNase I...
  4. doi request reprint Repositioning of ETO gene in cells treated with VP-16, an inhibitor of DNA-topoisomerase II
    Mikhail A Rubtsov
    Laboratory of Structural and Functional Organization of Chromosomes, Institute of Gene Biology of the Russian Academy of Sciences, 34 5 Vavilov Street, 119334 Moscow, Russia
    J Cell Biochem 104:692-9. 2008
    ..Together, our data corroborate the so called "breakage first" model of the origins of recurrent reciprocal translocation...
  5. pmc TMEM8 - a non-globin gene entrapped in the globin web
    Elena S Philonenko
    Institute of Gene Biology of the Russian Academy of Sciences, Vavilov Street 34 5, 119334 Moscow, Russia
    Nucleic Acids Res 37:7394-406. 2009
    ..An alternative chromatin hub is assembled, which includes some of the regulatory elements essential for the activation of globin gene expression. These regulatory elements should thus shuttle between two different chromatin hubs...
  6. pmc Mapping of the nuclear matrix-bound chromatin hubs by a new M3C experimental procedure
    Alexey A Gavrilov
    Laboratory of Structural and Functional Organization of Chromosomes, Institute of Gene Biology of the Russian Academy of Sciences, 34 5 Vavilov Street, 119334 Moscow, Russia
    Nucleic Acids Res 38:8051-60. 2010
    ....
  7. doi request reprint Early replication timing of the chicken alpha-globin gene domain correlates with its open chromatin state in cells of different lineages
    Denis B Klochkov
    Institute of Gene Biology, Russian Academy of Sciences, Vavilov Street 34 5, 119334 Moscow, Russia
    Genomics 93:481-6. 2009
    ....
  8. pmc Disclosure of a structural milieu for the proximity ligation reveals the elusive nature of an active chromatin hub
    Alexey A Gavrilov
    Institute of Gene Biology of the Russian Academy of Sciences, 119334 Moscow, Russia, University of Oslo, Center for Medical Studies in Russia, 119334 Moscow, Russia
    Nucleic Acids Res 41:3563-75. 2013
    ..The finding does not compromise the 3C protocol but allows the consideration of an active chromatin hub as a folded chromatin domain or a nuclear compartment rather than a rigid complex of regulatory elements...
  9. pmc Quantitative analysis of genomic element interactions by molecular colony technique
    Alexey A Gavrilov
    Group of Genome Spatial Organization, Institute of Gene Biology of the Russian Academy of Sciences, Moscow 119334, Russia, Laboratory of Viral RNA Biochemistry, Institute of Protein Research of the Russian Academy of Sciences, Pushchino, Moscow Region 142290, Russia, Laboratory of Cell Proliferation Problems, Koltzov Institute of Developmental Biology of the Russian Academy of Sciences, Moscow 119334, Russia, Laboratory of Structural and Functional Organization of Chromosomes, Institute of Gene Biology of the Russian Academy of Sciences, Moscow 119334, Russia and Faculty of Biology, M V Lomonosov Moscow State University, Moscow 119992, Russia
    Nucleic Acids Res 42:e36. 2014
    ..This indicates that either these elements do not interact directly in the majority of cells at a given time moment, or the formed DNA-protein complex cannot be stabilized by formaldehyde cross-linking. ..
  10. pmc A CTCF-dependent silencer located in the differentially methylated area may regulate expression of a housekeeping gene overlapping a tissue-specific gene domain
    Denis Klochkov
    Laboratory of Structural Functional Organization of Chromosomes, Institute of Gene Biology of the Russian Academy of Sciences, 34 5 Vavilov Street, 117334 Moscow, Russia
    Mol Cell Biol 26:1589-97. 2006
    ....
  11. ncbi request reprint Unusual compartmentalization of CTCF and other transcription factors in the course of terminal erythroid differentiation
    Omar L Kantidze
    Laboratory of Structural and Functional Organization of Chromosomes, Institute of Gene Biology RAS, 34 5 Vavilov Street, 119334 Moscow, Russia
    Biochim Biophys Acta 1773:924-33. 2007
    ....
  12. pmc Dual effect of heat shock on DNA replication and genome integrity
    Artem K Velichko
    Institute of Gene Biology, Russian Academy of Sciences, 119334 Moscow, Russia
    Mol Biol Cell 23:3450-60. 2012
    ....
  13. pmc Actual ligation frequencies in the chromosome conformation capture procedure
    Alexey A Gavrilov
    Institute of Gene Biology of the Russian Academy of Sciences, Moscow, Russia
    PLoS ONE 8:e60403. 2013
    ..Although this low yield of 3C ligation products may be explained entirely by technical issues, it may as well reflect a low frequency of interaction between DNA regulatory elements in vivo...
  14. doi request reprint Chromatin loops, illegitimate recombination, and genome evolution
    Omar L Kantidze
    Laboratory of Structural and Functional Organization of Chromosomes, Institute of Gene Biology of the Russian Academy of Sciences, Moscow, Russia
    Bioessays 31:278-86. 2009
    ..In this review, we consider recombination between DNA loop anchorage regions as a possible source of genome evolution...
  15. doi request reprint Transcription of the AML1/ETO chimera is guided by the P2 promoter of the AML1 gene in the Kasumi-1 cell line
    Elena N Markova
    Laboratory of Structural and Functional Organization of Chromosomes, Institute of Gene Biology RAS, 34 5 Vavilova Street, 119334 Moscow, Russia
    Gene 510:142-6. 2012
    ..In our work, we attempted to shed light on this essential issue. We investigated the promoter from which transcription of the AML1/ETO gene is initiated and defined the three-dimensional structure of the whole rearranged locus...
  16. ncbi request reprint Specific radial positions of centromeres of human chromosomes X, 1, and 19 remain unchanged in chromatin-depleted nuclei of primary human fibroblasts: evidence for the organizing role of the nuclear matrix
    Natalia V Petrova
    Laboratory of Structural and Functional Organization of Chromosomes, Institute of Gene Biology RAS, Vavilov Street 34 5, 119334 Moscow, Russia
    J Cell Biochem 96:850-7. 2005
    ..These results strongly suggest that the characteristic organization of interphase chromosomes is supported by the proteinous nuclear matrix and is not maintained by simple repulsing of negatively charged chromosomes...
  17. ncbi request reprint Inhibition of DNA topoisomerase II may trigger illegitimate recombination in living cells: experiments with a model system
    Olga N Umanskaya
    Institute of Gene Biology, Russian Academy of Sciences, Vavilov str 34 5, 119334 Moscow, Russia
    J Cell Biochem 99:598-608. 2006
    ....
  18. ncbi request reprint Chemotherapy-related secondary leukemias: A role for DNA repair by error-prone non-homologous end joining in topoisomerase II - Induced chromosomal rearrangements
    Omar L Kantidze
    Laboratory of Structural and Functional Organization of Chromosomes, Institute of Gene Biology RAS, 34 5 Vavilov Street, 119334 Moscow, Russia
    Gene 391:76-9. 2007
    ....
  19. pmc Mechanism of heat stress-induced cellular senescence elucidates the exclusive vulnerability of early S-phase cells to mild genotoxic stress
    Artem K Velichko
    Laboratory of Structural and Functional Organization of Chromosomes, Institute of Gene Biology, Russian Academy of Sciences, 119334 Moscow, Russia
    Nucleic Acids Res 43:6309-20. 2015
    ..This investigation of heat stress-induced cellular senescence elucidates the mechanisms underlying the exclusive sensitivity of early S-phase cells to ultra-low doses of agents that induce single-stranded DNA breaks. ..
  20. pmc HP1α is not necessary for the structural maintenance of centromeric heterochromatin
    Artem K Velichko
    Laboratory of Structural and Functional Organization of Chromosomes, Institute of Gene Biology of the Russian Academy of Sciences, Moscow, Russia
    Epigenetics 6:380-7. 2011
    ..Therefore, it is likely that HP1α is simply redistributed to euchromatic regions. We propose that this redistribution is essential for reversal of the transcriptional status of euchromatic and heterochromatic compartments...
  21. doi request reprint Formaldehyde fixation of cells does not greatly reduce the ability to amplify cellular DNA
    Alexey Gavrilov
    Laboratory of Structural and Functional Organization of Chromosomes, Institute of Gene Biology of the Russian Academy of Sciences, 119334 Moscow, Russia
    Anal Biochem 390:94-6. 2009
    ..The loss of amplifiability is independent of the length of the amplification region and the degree to which DNA is compacted on packaging into chromatin...
  22. pmc The Role of Crowding Forces in Juxtaposing β-Globin Gene Domain Remote Regulatory Elements in Mouse Erythroid Cells
    Arkadiy K Golov
    Institute of Gene Biology of the Russian Academy of Sciences, Vavilov Street 34 5, 119334, Moscow, Russia
    PLoS ONE 10:e0139855. 2015
    ..In addition to proving the role of crowding forces in shaping interphase chromatin, our results suggest that the folding of the chromatin fiber is a major determinant in juxtaposing remote genomic elements. ..
  23. pmc Visualization of individual DNA loops and a map of loop domains in the human dystrophin gene
    Olga V Iarovaia
    Institute of Gene Biology RAS, 34 5 Vavilov Street, 119334 Moscow, Russia
    Nucleic Acids Res 32:2079-86. 2004
    ..These results strongly suggest that partitioning of genomic DNA into specific loops attached to a skeletal structure is a characteristic feature of eukaryotic chromosome organization in interphase...
  24. ncbi request reprint The upstream area of the chicken alpha-globin gene domain is transcribed in both directions in the same cells
    Victoria Borunova
    Laboratory of Structural and Functional Organization of Chromosomes, Institute of Gene Biology, Russian Academy of Sciences, 34 5 Vavilov Street, 119334 Moscow, Russia
    FEBS Lett 579:4746-50. 2005
    ....
  25. pmc Spatial organization of the chicken beta-globin gene domain in erythroid cells of embryonic and adult lineages
    Sergey V Ulianov
    Institute of Gene Biology of the Russian Academy of Sciences, 34 5 Vavilov Str, 119334, Moscow, Russia
    Epigenetics Chromatin 5:16. 2012
    ..abstract:..
  26. pmc Active chromatin and transcription play a key role in chromosome partitioning into topologically associating domains
    Sergey V Ulianov
    Institute of Gene Biology, RAS, 119334 Moscow, Russia Department of Molecular Biology, Lomonosov Moscow State University, 119991 Moscow, Russia
    Genome Res 26:70-84. 2016
    ..Finally, we test this hypothesis by polymer simulations and find that TAD partitioning may be explained by different modes of inter-nucleosomal interactions for active and inactive chromatin. ..
  27. ncbi request reprint Breakpoint clusters: reason or consequence?
    Andrey A Bystritskiy
    Laboratory of Structural and Functional Organization of Chromosomes, Institute of Gene Biology of the Russian Academy of Sciences, Vavilov str 34 5, 119334 Moscow, Russia
    Crit Rev Eukaryot Gene Expr 14:65-77. 2004
    ..We also touch on the question of whether the structure of corresponding proteins is related to the positions of breakpoints. Finally, we refer to recent works on chromosome territories and their distribution in the interphase nucleus...