M D Ter-Avanesyan

Summary

Affiliation: Institute of Experimental Cardiology
Country: Russia

Publications

  1. ncbi request reprint Prions: infectious proteins with genetic properties
    M D Ter-Avanesyan
    Institute of Experimental Cardiology, Cardiology Research Center, Moscow, 121552, Russia
    Biochemistry (Mosc) 64:1382-90. 1999
  2. ncbi request reprint Increased expression of Hsp40 chaperones, transcriptional factors, and ribosomal protein Rpp0 can cure yeast prions
    Dmitry S Kryndushkin
    Institute of Experimental Cardiology, Cardiology Research Center, 3rd Cherepkovskaya Street 15A, 121552 Moscow, Russia
    J Biol Chem 277:23702-8. 2002
  3. pmc The role of the N-terminal oligopeptide repeats of the yeast Sup35 prion protein in propagation and transmission of prion variants
    Irina S Shkundina
    Institute of Experimental Cardiology, Cardiology Research Center, Moscow, Russia
    Genetics 172:827-35. 2006
  4. ncbi request reprint Yeast polypeptide chain release factors eRF1 and eRF3 are involved in cytoskeleton organization and cell cycle regulation
    Igor A Valouev
    Institute of Experimental Cardiology, Cardiology Research Center, Moscow, Russia
    Cell Motil Cytoskeleton 52:161-73. 2002
  5. pmc C-terminal truncation of alpha-COP affects functioning of secretory organelles and calcium homeostasis in Hansenula polymorpha
    Maria B Chechenova
    Institute of Experimental Cardiology, Cardiology Research Center, 121552 Moscow, Russia
    Eukaryot Cell 3:52-60. 2004
  6. ncbi request reprint Deletion analysis of the SUP35 gene of the yeast Saccharomyces cerevisiae reveals two non-overlapping functional regions in the encoded protein
    M D Ter Avanesyan
    Institute of Experimental Cardiology, Cardiology Research Centre, Moscow, Russia
    Mol Microbiol 7:683-92. 1993
  7. pmc The SUP35 omnipotent suppressor gene is involved in the maintenance of the non-Mendelian determinant [psi+] in the yeast Saccharomyces cerevisiae
    M D Ter Avanesyan
    Institute of Experimental Cardiology, Cardiology Research Center, Moscow, Russia
    Genetics 137:671-6. 1994
  8. ncbi request reprint C-terminal truncation of the Sup35 protein increases the frequency of de novo generation of a prion-based [PSI+] determinant in Saccharomyces cerevisiae
    N V Kochneva-Pervukhova
    Institute of Experimental Cardiology, Cardiology Research Center, 121552 Moscow, Russia
    Curr Genet 34:146-51. 1998
  9. pmc Interaction between yeast Sup45p (eRF1) and Sup35p (eRF3) polypeptide chain release factors: implications for prion-dependent regulation
    S V Paushkin
    Institute of Experimental Cardiology, Cardiology Research Center, Moscow, Russia
    Mol Cell Biol 17:2798-805. 1997
  10. ncbi request reprint Translation termination factors function outside of translation: yeast eRF1 interacts with myosin light chain, Mlc1p, to effect cytokinesis
    I A Valouev
    Institute of Experimental Cardiology, Cardiology Research Center, 3rd Cherepkovskaya Street 15A, 121552 Moscow, Russia
    Mol Microbiol 53:687-96. 2004

Collaborators

  • V V Kushnirov
  • Y O Chernoff
  • M Boguta
  • M F Tuite
  • S G Inge-Vechtomov
  • V N Smirnov
  • S V Paushkin
  • M O Agaphonov
  • A I Alexandrov
  • I A Valouev
  • N V Kochneva-Pervukhova
  • A N Packeiser
  • V N Urakov
  • E G Afanasieva
  • Irina S Shkundina
  • Maria B Chechenova
  • G V Serpionov
  • Vladimir N Smirnov
  • Igor A Valouev
  • Dmitry S Kryndushkin
  • M B Chechenova
  • N V Kochneva Pervukhova
  • A V Fokina
  • T A Plotnikova
  • H A Kang
  • N V Romanova
  • Alexander V Deev
  • Nina V Romanova
  • Anna N Packeiser
  • Michael O Agaphonov
  • E I Lewitin
  • E S Choi
  • V S Kosorukov
  • Y A Polyakova
  • N I Shimanova
  • V D Shcherbukhin
  • A I Poznyakovski
  • B S Cox
  • M D Ter Avanesyan
  • A R Dagkesamanskaya
  • S A Didichenko

Detail Information

Publications26

  1. ncbi request reprint Prions: infectious proteins with genetic properties
    M D Ter-Avanesyan
    Institute of Experimental Cardiology, Cardiology Research Center, Moscow, 121552, Russia
    Biochemistry (Mosc) 64:1382-90. 1999
    ..The significance of the prion phenomenon for biology and medicine is discussed...
  2. ncbi request reprint Increased expression of Hsp40 chaperones, transcriptional factors, and ribosomal protein Rpp0 can cure yeast prions
    Dmitry S Kryndushkin
    Institute of Experimental Cardiology, Cardiology Research Center, 3rd Cherepkovskaya Street 15A, 121552 Moscow, Russia
    J Biol Chem 277:23702-8. 2002
    ..Thus, the induction of chaperone expression by these proteins could explain their prion-curing effects...
  3. pmc The role of the N-terminal oligopeptide repeats of the yeast Sup35 prion protein in propagation and transmission of prion variants
    Irina S Shkundina
    Institute of Experimental Cardiology, Cardiology Research Center, Moscow, Russia
    Genetics 172:827-35. 2006
    ..These data suggest that [PSI+] variability is primarily defined by differential folding of the Sup35-PrD oligopeptide-repeat region...
  4. ncbi request reprint Yeast polypeptide chain release factors eRF1 and eRF3 are involved in cytoskeleton organization and cell cycle regulation
    Igor A Valouev
    Institute of Experimental Cardiology, Cardiology Research Center, Moscow, Russia
    Cell Motil Cytoskeleton 52:161-73. 2002
    ..The data obtained suggest that eRF1 and eRF3 play additional, nontranslational roles in the yeast cell...
  5. pmc C-terminal truncation of alpha-COP affects functioning of secretory organelles and calcium homeostasis in Hansenula polymorpha
    Maria B Chechenova
    Institute of Experimental Cardiology, Cardiology Research Center, 121552 Moscow, Russia
    Eukaryot Cell 3:52-60. 2004
    ..Overexpression of Pmr1p suppressed some ret1 mutant phenotypes, namely, Ca2+ dependence and enhanced uPA secretion. The role of COPI-dependent vesicular transport in cellular Ca2+ homeostasis is discussed...
  6. ncbi request reprint Deletion analysis of the SUP35 gene of the yeast Saccharomyces cerevisiae reveals two non-overlapping functional regions in the encoded protein
    M D Ter Avanesyan
    Institute of Experimental Cardiology, Cardiology Research Centre, Moscow, Russia
    Mol Microbiol 7:683-92. 1993
    ..Thus, the data obtained define two domains within the Sup35 protein which are responsible for different functions...
  7. pmc The SUP35 omnipotent suppressor gene is involved in the maintenance of the non-Mendelian determinant [psi+] in the yeast Saccharomyces cerevisiae
    M D Ter Avanesyan
    Institute of Experimental Cardiology, Cardiology Research Center, Moscow, Russia
    Genetics 137:671-6. 1994
    ..It was shown that the first 114 amino acids of Sup35p are sufficient to maintain the [psi+] determinant. We propose that the Sup35p serves as a trans-acting factor required for the maintenance of [psi+]...
  8. ncbi request reprint C-terminal truncation of the Sup35 protein increases the frequency of de novo generation of a prion-based [PSI+] determinant in Saccharomyces cerevisiae
    N V Kochneva-Pervukhova
    Institute of Experimental Cardiology, Cardiology Research Center, 121552 Moscow, Russia
    Curr Genet 34:146-51. 1998
    ..The data suggest that the presence of Sup35p N-terminal proteolytic fragments can cause [PSI+] appearance in wild-type yeast cells...
  9. pmc Interaction between yeast Sup45p (eRF1) and Sup35p (eRF3) polypeptide chain release factors: implications for prion-dependent regulation
    S V Paushkin
    Institute of Experimental Cardiology, Cardiology Research Center, Moscow, Russia
    Mol Cell Biol 17:2798-805. 1997
    ..This phenomenon represents a novel mechanism of regulation of gene expression at the posttranslational level...
  10. ncbi request reprint Translation termination factors function outside of translation: yeast eRF1 interacts with myosin light chain, Mlc1p, to effect cytokinesis
    I A Valouev
    Institute of Experimental Cardiology, Cardiology Research Center, 3rd Cherepkovskaya Street 15A, 121552 Moscow, Russia
    Mol Microbiol 53:687-96. 2004
    ..The data obtained demonstrate that yeast eRF1 has an important non-translational function effecting cytokinesis via interaction with Mlc1p...
  11. ncbi request reprint In vitro propagation of the prion-like state of yeast Sup35 protein
    S V Paushkin
    Institute of Experimental Cardiology, Cardiology Research Center, 3rd Cherepkovskaya Street 15A, Moscow 121552, Russia
    Science 277:381-3. 1997
    ..Sup35pPSI+ was purified and showed high conversion activity, thus confirming the prion hypothesis for Sup35p...
  12. ncbi request reprint Nucleotide sequence of the SUP2 (SUP35) gene of Saccharomyces cerevisiae
    V V Kushnirov
    Institute of Experimental Cardiology, U S S R Cardiology Research Center, Moscow
    Gene 66:45-54. 1988
    ..One of these proteins is supposed to be imported into mitochondria. Possible functions of the SUP2 gene product(s), especially its putative activity as a soluble factor controlling the fidelity of translation, are discussed...
  13. ncbi request reprint Ribosome-bound EF-1 alpha-like protein of yeast Saccharomyces cerevisiae
    S A Didichenko
    Institute of Experimental Cardiology, USSR Cardiology Research Center, Moscow
    Eur J Biochem 198:705-11. 1991
    ..Also, in a sucrose gradient, Sup2 preferentially cosedimented with the 40S ribosomal subunit, but not with the 60S subunit. The functional significance of this association is discussed...
  14. ncbi request reprint Conservative system for dosage-dependent modulation of translational fidelity in eukaryotes
    Y O Chernoff
    Department of Genetics, Leningrad University, Moscow, Russia
    Biochimie 74:455-61. 1992
    ..However, the C-terminal part which is required for yeast viability has a common origin but a separate evolution from that of the EF-Tu protein family...
  15. ncbi request reprint Divergence and conservation of SUP2 (SUP35) gene of yeast Pichia pinus and Saccharomyces cerevisiae
    V V Kushnirov
    Institute of Experimental Cardiology, U S S R Cardiology Research Center, Moscow
    Yeast 6:461-72. 1990
    ..cerevisiae were found in P. pinus and some other yeast species by the immunoblotting technique. The relation between the evolutionary conservation of different regions of the Sup2 protein and their functional significance is discussed...
  16. pmc Prion properties of the Sup35 protein of yeast Pichia methanolica
    V V Kushnirov
    Institute of Experimental Cardiology, Cardiology Research Center, 3 rd Cherepkovskaya Street, 15a, Moscow 121552, Russia
    EMBO J 19:324-31. 2000
    ..No transfer of prion state between the two Sup35p variants was observed, which reveals a 'species barrier' for the [PSI(+)] prions. The data obtained show that prion properties are conserved within at least a part of this protein family...
  17. ncbi request reprint Chaperones that cure yeast artificial [PSI+] and their prion-specific effects
    V V Kushnirov
    Institute of Experimental Cardiology, Cardiology Research Centre, Third Cherepkovskaya Street 15A, 121552, Moscow, Russia
    Curr Biol 10:1443-6. 2000
    ..Our results imply that homologs of these chaperones may be active against mammalian prion and amyloid diseases...
  18. pmc Mechanism of inhibition of Psi+ prion determinant propagation by a mutation of the N-terminus of the yeast Sup35 protein
    N V Kochneva Pervukhova
    Institute of Experimental Cardiology, Cardiology Research Center, 3rd Cherepkovskaya Street 15A, Moscow 121552, Russia
    EMBO J 17:5805-10. 1998
    ....
  19. ncbi request reprint A novel vacuolar protein encoded by SSU21 / MCD4 is involved in cell wall integrity in yeast
    A N Packeiser
    Institute of Experimental Cardiology, Cardiology Research Center, 3rd Cherepkovskaya Str 15A, Moscow 121552, Russia
    Yeast 15:1485-501. 1999
    ..To our knowledge, this is the first example of a yeast vacuolar protein whose alteration results in a cell wall defect...
  20. ncbi request reprint Mutation of the homologue of GDP-mannose pyrophosphorylase alters cell wall structure, protein glycosylation and secretion in Hansenula polymorpha
    M O Agaphonov
    Institute of Experimental Cardiology, Cardiology Research Centre, 3rd Cherepkovskaya Street 15A, Moscow 121552, Russia
    Yeast 18:391-402. 2001
    ..The influence of the opu24 mutation on endoplasmic reticulum-associated protein degradation is discussed. The GenBank Accession No. for the OPU24 sequence is AF234177...
  21. pmc Itt1p, a novel protein inhibiting translation termination in Saccharomyces cerevisiae
    V N Urakov
    Institute of Experimental Cardiology, Cardiology Research Center, Moscow, 121552, Russia
    BMC Mol Biol 2:9. 2001
    ..Recent studies has shown that proteins interacting with these release factors can modulate the efficiency of nonsense codon readthrough...
  22. pmc Propagation of the yeast prion-like [psi+] determinant is mediated by oligomerization of the SUP35-encoded polypeptide chain release factor
    S V Paushkin
    Institute of Experimental Cardiology, Cardiology Research Center, Moscow, Russia
    EMBO J 15:3127-34. 1996
    ..We propose that Hsp104p plays a role in establishing stable [psi+] inheritance by splitting up Sup35p aggregates and thus ensuring equidistribution of the prion-like Sup35p isoform to daughter cells at cell divisions...
  23. doi request reprint Interspecies transmission of prions
    E G Afanasieva
    Bach Institute of Biochemistry, Russian Academy of Sciences, Moscow, Russia
    Biochemistry (Mosc) 76:1375-84. 2011
    ..This allowed to show that the barrier in prion transmission can be observed even upon copolymerization of two prionogenic proteins. Available data allow elucidation of the mechanisms that impede prion transmission or make it impossible...
  24. ncbi request reprint [Psi(+)] prion generation in yeast: characterization of the 'strain' difference
    N V Kochneva Pervukhova
    Institute of Experimental Cardiology, Cardiology Research Center, 121552 Moscow, Russia
    Yeast 18:489-97. 2001
    ..This difference correlated with variation in properties of the Sup35 protein. A novel type of prion instability was observed: some [PSI(+)] with weak suppressor efficiency could convert spontaneously into strong suppressor determinants...
  25. ncbi request reprint Inactivation of the Hansenula polymorpha PMR1 gene affects cell viability and functioning of the secretory pathway
    M O Agaphonov
    Institute of Experimental Cardiology, Cardiology Research Center, Moscow, Russia
    FEMS Yeast Res 7:1145-52. 2007
    ..At the same time, the pmr1 mutation improved the secretion of human urokinase and decreased its intracellular aggregation, indicating an influence of the mutation on the protein folding in the ER...
  26. pmc Wild type huntingtin toxicity in yeast: Implications for the role of amyloid cross-seeding in polyQ diseases
    A I Alexandrov
    a Bach Institute of Biochemistry, Research Center of Biotechnology of the Russian Academy of Sciences, Moscow, Russia
    Prion 10:221-7. 2016
    ..We hypothesize that similar mechanisms may enable proteins, which possess expanded Q-rich tracts but are not associated with diseases, to promote the development of polyQ diseases. ..